CN102949659B - Traditional Chinese medicine composition for treating hepatitis B - Google Patents
Traditional Chinese medicine composition for treating hepatitis B Download PDFInfo
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- CN102949659B CN102949659B CN201210358448.1A CN201210358448A CN102949659B CN 102949659 B CN102949659 B CN 102949659B CN 201210358448 A CN201210358448 A CN 201210358448A CN 102949659 B CN102949659 B CN 102949659B
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Abstract
The invention relates to a traditional Chinese medicine composition for treating hepatitis B, comprising the following traditional Chinese medicine ingredients in parts by weight: 6-18 parts of radix bupleuri, 6-18 parts of angelica sinensis, 10-20 parts of radix paeoniae alba, 6-18 parts of rhizoma atractylodis macrocephalae, 6-18 parts of poria cocos, 5-15 parts of liquorice, 4-12 parts of mint, 6-18 parts of rhizoma cyperi, 6-18 parts of radix curcumae, 10-20 parts of rhizoma corydalis, 10-30 parts of capillary artemisia, 10-20 parts of dactylicapnos scandens, 20-40 parts of astragalus mongholicus and 6-18 parts of mangnolia officinalis. The traditional Chinese medicine composition has the effects of soothing the liver, tonifying the lung, enriching and nourishing the blood, strengthening the spleen, tonifying the qi, clearing away the heat and the toxic materials, regulating the qi, dispelling the melancholy, drying the dampness and alleviating the water retention; when being used for treating the hepatitis B, the traditional Chinese medicine composition has remarkable curative effect and reliable function; and the traditional Chinese medicine composition is wide in ingredient source, simple and convenient for preparation and free of toxic and side effects.
Description
Technical field
The present invention relates to a kind of not medicinal preparation of definite structure of traditional herbal medicines, especially a kind of Chinese medicine composition for the treatment of hepatitis B.
Background technology
Hepatitis B is a kind of by caused disease after hepatitis B virus (HBV) infection body.Clinical manifestation is: weak, loss of appetite, feel sick, vomit, detest oil, hepatomegaly and abnormal liver function.Hepatitis B virus is a kind of Hepadna Virus, is mainly present in hepatocyte and damages hepatocyte, causes hepatocyte inflammation, necrosis, fibrosis.Think that at present the pathogenesis of hepatitis B and the immunne response of body are closely related, it is generally acknowledged, hepatitis B virus is invaded after human body, and virus itself does not directly cause hepatocellular pathological changes, and just utilize the nutriment of hepatocyte picked-up to depend on for existence, and copy in hepatocyte.Its surface antigen copying, e antigen and cAg, be all released on liver plasma membrane, recognizes, and react with the immune system of exciting human.When the immunologic function of human body has been destroyed the liver plasma membrane that contains virus antigen material, will cause hepatocellular damage, necrosis and inflammation.At present, do not have medicine to effect a radical cure hepatitis B completely, its treatment is mainly antiviral therapy, and conventional antiviral drugs mainly contains: four kinds of interferon, lamivudine, adefovirdipivoxil and Entecavirs etc.Antiviral drugs can only be removed or the lasting HBV of inhibition, improve inflammation and the necrosis of liver, prevention is to carrying out hepatopathy, comprise liver cirrhosis and (or) hepatocarcinoma development, to integrating virus without effect, to the covalence closed annular DNA of the superhelix of HBV in liver cell nuclear (cccDNA) also without effect, therefore CCCDNA becomes the template that virus replication is transcribed again after drug withdrawal.
The traditional Chinese medical science thinks, strongly fragrant in damp and hot heresy of the cause of disease epidemic disease poison of hepatitis B, with the passing of time do not heal, or interior tired taste, the raw deficiency of QI and bloodization; Or evil strongly fragrant and from cremating, consumption impairment of YIN Tianjin; Or burning hot heresy gos deep into nutrient blood, hematozemia is moved blood, damage liver-yin.B-type hepatitis position is mainly at liver spleen kidney.The damp and hot stasis of blood of epidemic disease poison is strongly fragrant, and liver spleen kidney loses and supports is its main pathology link.Pathologic feature is deficiency in origin and excess in superficiality, simulataneous insufficiency and excessive.
According to the pathogeny of hepatitis B, it is Therapeutic Principle that the traditional Chinese medical science be take nourishing blood to suppress the hyperactive liver, tonifying speen and tonifying kidney, heat-clearing and toxic substances removing, dispersing the stagnated live-QI to relieve the stagnation of QI, carries out dialectical composition of prescription, to reach the object for the treatment of both the principal and the secondary aspects of a disease at the same time.
Summary of the invention
In order to overcome the deficiencies in the prior art, the invention provides a kind ofly prepare conveniently, medicine source is wide, cost is low, evident in efficacy, reliable effect, a kind of Chinese medicine composition for the treatment of hepatitis B of having no side effect.
The technical solution adopted for the present invention to solve the technical problems is: a kind of Chinese medicine composition for the treatment of hepatitis B, is characterized in that: its raw material of Chinese medicine by following weight portion proportioning forms: Radix Bupleuri 6-18 part, Radix Angelicae Sinensis 6-18 part, Radix Paeoniae Alba 10-20 part, Rhizoma Atractylodis Macrocephalae 6-18 part, Poria 6-18 part, Radix Glycyrrhizae 5-15 part, Herba Menthae 4-12 part, Rhizoma Cyperi 6-18 part, Radix Curcumae 6-18 part, Rhizoma Corydalis 10-20 part, Herba Artemisiae Scopariae 10-30 part, Radix dactylicapni (Radix Dactylicapnotis) 10-20 part, Radix Astragali 20-40 part, Cortex Magnoliae Officinalis 6-18 part.
The preferred technical solution of the present invention is: a kind of Chinese medicine composition for the treatment of hepatitis B, is characterized in that: its raw material of Chinese medicine by following weight portion proportioning forms: 12 parts of Radix Bupleuri, 12 parts of Radix Angelicae Sinensis, 15 parts of the Radix Paeoniae Albas, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts, Poria, 10 parts, Radix Glycyrrhizae, 8 parts of Herba Menthaes, 12 parts of Rhizoma Cyperis, 12 parts of Radix Curcumaes, 15 parts of Rhizoma Corydalis, 20 parts of Herba Artemisiae Scopariaes, 15 parts of Radix dactylicapni (Radix Dactylicapnotis)s, 30 parts of the Radixs Astragali, 12 parts of Cortex Magnoliae Officinalis.
Chinese medicine composition of the present invention is under Traditional Chinese medical theory and clinical experience guidance, selected medicament composing prescription.In Chinese medicine composition of the present invention: Radix Bupleuri have evacuate bring down a fever, the effect of yang invigorating soothing liver-QI; Radix Angelicae Sinensis have enrich blood invigorate blood circulation, the effect of menstruction regulating and pain relieving, loosening bowel to relieve constipation; The Radix Paeoniae Alba has the effect of nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing receipts antiperspirant; The Rhizoma Atractylodis Macrocephalae has invigorating the spleen and benefiting QI, dampness diuretic, the antiabortive effect of hidroschesis; Poria has the effect of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming; Radix Glycyrrhizae has the effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, coordinating the actions of various ingredients in a prescription; Herba Menthae has the effect of dispelling wind and heat pathogens, clear profit removing toxic substances, dispersing the stagnated live-QI to relieve the stagnation of QI; Rhizoma Cyperi has the effect of liver-smoothing, qi-regulating, resolving depression pain relieving; Radix Curcumae has the effect of regulating qi to disperse stagnation, heart fire-clearing upset-relieving; Rhizoma Corydalis has the effect of promoting blood circulation to remove blood stasis, promoting the circulation of QI pain relieving; Herba Artemisiae Scopariae has the effect of clearing away heat-damp and promoting diuresis, hepatic cholagogic; Radix dactylicapni (Radix Dactylicapnotis) has the effect of analgesia, hemostasis, blood pressure lowering; The Radix Astragali has that benefiting QI for strengthening the superficies, tonifying the lung spleen invigorating, arresting sweating are admittedly de-, wind dispelling is transported malicious effect; Cortex Magnoliae Officinalis has circulation of qi promoting removing food stagnancy, dampness except effect full, lowering the adverse QI to relieve asthma.Drug component in the present composition is through dialectical compatibility, complements each other using, and has synergism, plays altogether the effect of soothing liver-QI tonifying the lung, blood-supplementing blood-nourishing, invigorating the spleen and benefiting QI, heat-clearing and toxic substances removing, the resolving depression of regulating the flow of vital energy, dampness diuretic, reaches the object for the treatment of hepatitis B.
The component of the present composition all adopts natural raw material of Chinese medicine, and its preparation is easy, medicine source is wide, cost is low.It follows the prescriptions principle of the traditional Chinese medical science, and various component drug adopt the use that is decocted in water for oral dose.Through clinical practice checking, it is evident in efficacy, reliable effect, and the property of medicine is gentle, does not occur toxic and side effects, total effective rate 81.5%, cure rate reaches 53.7%.
The specific embodiment
Below in conjunction with embodiment, the present invention will be further described.
Embodiment 1
Treat a Chinese medicine composition for hepatitis B, its raw material of Chinese medicine by following weight proportion forms: Radix Bupleuri 12g, Radix Angelicae Sinensis 12g, Radix Paeoniae Alba 15g, Rhizoma Atractylodis Macrocephalae 12g, Poria 12g, Radix Glycyrrhizae 10g, Herba Menthae 8g, Rhizoma Cyperi 12g, Radix Curcumae 12g, Rhizoma Corydalis 15g, Herba Artemisiae Scopariae 20g, Radix dactylicapni (Radix Dactylicapnotis) 15g, Radix Astragali 30g, Cortex Magnoliae Officinalis 12g.
Embodiment 2
Treat a Chinese medicine composition for hepatitis B, its raw material of Chinese medicine by following weight proportion forms: Radix Bupleuri 6g, Radix Angelicae Sinensis 18g, Radix Paeoniae Alba 10g, Rhizoma Atractylodis Macrocephalae 18g, Poria 6g, Radix Glycyrrhizae 15g, Herba Menthae 4g, Rhizoma Cyperi 18g, Radix Curcumae 6g, Rhizoma Corydalis 20g, Herba Artemisiae Scopariae 10g, Radix dactylicapni (Radix Dactylicapnotis) 20g, Radix Astragali 20g, Cortex Magnoliae Officinalis 18g.
Embodiment 3
Treat a Chinese medicine composition for hepatitis B, its raw material of Chinese medicine by following weight proportion forms: Radix Bupleuri 18g, Radix Angelicae Sinensis 6g, Radix Paeoniae Alba 20g, Rhizoma Atractylodis Macrocephalae 6g, Poria 18g, Radix Glycyrrhizae 5g, Herba Menthae 12g, Rhizoma Cyperi 6g, Radix Curcumae 18g, Rhizoma Corydalis 10g, Herba Artemisiae Scopariae 30g, Radix dactylicapni (Radix Dactylicapnotis) 10g, Radix Astragali 40g, Cortex Magnoliae Officinalis 6g.
Embodiment 4
Treat a Chinese medicine composition for hepatitis B, its raw material of Chinese medicine by following weight proportion forms: Radix Bupleuri 8g, Radix Angelicae Sinensis 13g, Radix Paeoniae Alba 13g, Rhizoma Atractylodis Macrocephalae 15g, Poria 10g, Radix Glycyrrhizae 13g, Herba Menthae 7g, Rhizoma Cyperi 16g, Radix Curcumae 8g, Rhizoma Corydalis 18g, Herba Artemisiae Scopariae 15g, Radix dactylicapni (Radix Dactylicapnotis) 18g, Radix Astragali 25g, Cortex Magnoliae Officinalis 16g.
Embodiment 5
Treat a Chinese medicine composition for hepatitis B, its raw material of Chinese medicine by following weight proportion forms: Radix Bupleuri 15g, Radix Angelicae Sinensis 8g, Radix Paeoniae Alba 19g, Rhizoma Atractylodis Macrocephalae 9g, Poria 16g, Radix Glycyrrhizae 8g, Herba Menthae 10g, Rhizoma Cyperi 9g, Radix Curcumae 16g, Rhizoma Corydalis 12g, Herba Artemisiae Scopariae 25g, Radix dactylicapni (Radix Dactylicapnotis) 12g, Radix Astragali 35g, Cortex Magnoliae Officinalis 9g.
Chinese medicine composition in embodiment of the present invention decocting method is routinely produced medicament.Concrete grammar is as follows: the raw material of Chinese medicine of prescription is put into container, add cold water and cover powder, soak 15～20 minutes, then add water and do not have approximately 8 centimetres of powder, decoct for the first time.At a simmer, adopt intense fire to decoct, after boiling, use slow fire boiling 20～30 minutes; Decoct for the second time, add water and do not have approximately 6 centimetres of powder, after water boils, decoct 15～20 minutes.Twice decoction extracting juice that removes slag, merges.
Treat a Chinese medicine composition for hepatitis B, clinical efficacy is summed up:
One, general data: this Chinese medicine composition is applied to observe case 54 examples, male 28 examples wherein, female's 26 examples, age 20-70 year.
Two, usage and dosage: during clinical practice, the component in compositions, consumption are taken the circumstances into consideration increase and decrease according to patient's body weight, age and symptom.Within ten days, be a course for the treatment of, one day potion, the about 300ml of twice extracting juice of decocting, minute morning, late twice warm taking.Period in a medicine is avoided tobacco and wine, avoids eating anything raw or cold, pungent, stimulation, greasy thing.
Three, criterion of therapeutical effect: according to < < viral hepatitis Efficacy of Traditional Chinese Medicine criterion > > judgement curative effect.
Four, therapeutic effect: in this clinical observation case, take medicine 5-20 the course for the treatment of, cure 29 examples, 15 examples that take a turn for the better, invalid 10 examples.During treatment, there is not toxic and side effects.
Five, model case:
Case 1:
In certain, man, 42 years old, side of body rib dull pain was had a medical check-up, and finds to suffer from hepatitis B, with liver function injury.Disease is seen: complexion clouding, and hidden have a red thread of red silk, side of body rib dull pain, loose stool, day row 2-4 time, edible oil is very greasy, tastelessness poor appetite, fatigue is sleepy unable, and order eyeball is without xanthochromia, yellowish urine, red tongue, yellow and greasy fur, thready and stringy pulse.Take 2 courses for the treatment of of medicament prepared by Chinese medicine composition provided by the invention, fatigue has and subtracts, and loose stool takes a turn for the better, day row twice, and side of body rib still has dull pain, red tongue with yellowish and greasy fur, thready and stringy pulse.Prolonged illness persistent ailment, it is quick-acting that difficulty is asked, and defence enters again.14 doses of former sides; Continue to take 2 courses for the treatment of, the pain over the hypochondriac region is Millefolium not, and stool is shaped, and once, waist lower limb is pantothenic acid slightly for day row, and tongue fur is yellowish slightly greasy, thready and rolling pulse.After this, plant with top plus-minusization always, continue to take after 6 courses for the treatment of, check liver function returns to normally completely, without obvious subjective symptoms, cures.
Case 2
Yin, male, 40 years old, main cause was weak, poor appetite 1 year, big belly meets the eye on every side Huang, yellowish urine more than 10.Disease is seen: dim complexion, white of the eye xanthochromia, abdominal distention poor appetite, yellowish urine icteric sclera, liver palm spider angioma, red tongue, yellow fur, stringy pulse.Laboratory and ultrasound diagnosis: splenomegaly, ALT and aspartate aminotransferase (AST) raise, and albumin reduces, gamma globulin obviously raises.Be diagnosed as: hepatitis B.Take 4 courses for the treatment of of medicament prepared by Chinese medicine composition provided by the invention, the transference cures such as weak, poor appetite, abdominal distention, the symptoms such as icteric sclera, yellowish urine take a turn for the better.Skin, mucosa have no obvious jaundice, and sclera has no obvious xanthochromia, and gamma globulin numerical value has reduction before, and ALT and aspartate aminotransferase (AST) still exceed standard, but amplitude obviously reduces; Continue to take 3 courses for the treatment of, on inspection, indices convergence is normal, and liver function recovery is normal, cures.
Claims (1)
1. a Chinese medicine composition for the treatment of hepatitis B, is characterized in that: its raw material of Chinese medicine by following weight proportion forms: Radix Bupleuri 12g, Radix Angelicae Sinensis 12g, Radix Paeoniae Alba 15g, Rhizoma Atractylodis Macrocephalae 12g, Poria 12g, Radix Glycyrrhizae 10g, Herba Menthae 8g, Rhizoma Cyperi 12g, Radix Curcumae 12g, Rhizoma Corydalis 15g, Herba Artemisiae Scopariae 20g, Radix dactylicapni (Radix Dactylicapnotis) 15g, Radix Astragali 30g, Cortex Magnoliae Officinalis 12g.
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| CN201210358448.1A CN102949659B (en) | 2012-09-25 | 2012-09-25 | Traditional Chinese medicine composition for treating hepatitis B |
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| CN201210358448.1A CN102949659B (en) | 2012-09-25 | 2012-09-25 | Traditional Chinese medicine composition for treating hepatitis B |
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| CN104873894A (en) * | 2015-05-26 | 2015-09-02 | 慕常松 | Traditional Chinese medicine composition for treating hepatitis |
| CN106334158A (en) * | 2016-10-17 | 2017-01-18 | 亳州学院 | Traditional Chinese medicine composition for treating virus hepatitis and preparation method thereof and application |
| CN112023005A (en) * | 2020-10-22 | 2020-12-04 | 禹州济德医院 | Traditional Chinese medicine preparation for treating viral hepatitis and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1365822A (en) * | 2001-10-07 | 2002-08-28 | 夏吾多杰 | 'Shugan Lidan' capsule and its preparing process |
| CN101647983A (en) * | 2009-09-08 | 2010-02-17 | 赵海城 | Liver soothing soup and preparation method thereof |
| CN101766801A (en) * | 2010-02-09 | 2010-07-07 | 山西大学 | Anti-depression Xiaoyao powder effective component and extraction method thereof |
-
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1365822A (en) * | 2001-10-07 | 2002-08-28 | 夏吾多杰 | 'Shugan Lidan' capsule and its preparing process |
| CN101647983A (en) * | 2009-09-08 | 2010-02-17 | 赵海城 | Liver soothing soup and preparation method thereof |
| CN101766801A (en) * | 2010-02-09 | 2010-07-07 | 山西大学 | Anti-depression Xiaoyao powder effective component and extraction method thereof |
Non-Patent Citations (5)
| Title |
|---|
| 中医中药诊治乙型病毒性肝炎述评;匡奕璜;《江西中医药》;19970221;第28卷(第01期);18-22 * |
| 余恒娣.慢性乙型肝炎的辨证分型论治.《中西医结合肝病杂志》.1998,86. * |
| 匡奕璜.中医中药诊治乙型病毒性肝炎述评.《江西中医药》.1997,第28卷(第01期),18-22. * |
| 慢性乙型肝炎的辨证分型论治;余恒娣;《中西医结合肝病杂志》;19981231;86 * |
| 梁瑞敏，张俊.论治肝炎五法.《中医药研究》.1995,(第04期),23-24. * |
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