CN102764411A - Drug composite for curing jaundice and preparation method thereof - Google Patents
Drug composite for curing jaundice and preparation method thereof Download PDFInfo
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Abstract
The invention provides a drug composite for curing jaundice. The drug composite comprises, by weight, 4 to 6 parts of veronicastrum caulopterum, 8 to 14 parts of virgate wormwood, 6 to 10 parts of linearstripe rabdosia herb, 3 to 5 parts of cape jasmine fruit, 7 to 10 parts of rhubarb, 4 to 6 parts of plantain seeds, 4 to 8 parts of betelnut peel, 4 to 6 parts of ginger peel, 4 to 6 parts of liquorice root, 3 to 7 parts of dried tangerine peel, 5 to 8 parts of pubescent holly root, 5 to 7 parts of herba hyperici japonici, 5 to 7 parts of semen platycladi, 4 to 6 parts of clerodendrumfortunatum and 5 to 8 parts of aloe. The drug composite both cures primary symptoms and cures accompanied symptoms or complications, strengthens body resistance and eliminates evils, treats both principal and secondary aspects of diseases. When the drug composite is applied to curing, the curing effect is rapid and good, and usually gets effects instantly. The drug composite can be used for emergent first-aids, in general outpatients or clinics, drugstores or as household emergency medicine. The drug composite has wide applications, and is a good medicine.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of compositions of treating the jaundice medicine and preparation method thereof.
Background technology
Jaundice is claimed jaundice again, is commonly called as " jaundice ", and being a kind of causes the sings and symptoms of skin, mucosa and sclera jaundice because serum mesobilirubin raises.Some hepatopathy, cholecystopathy and hematopathy cause the symptom of jaundice through regular meeting.
The fundamental symptoms of jaundice is:
1, the xanthochromia of tissue such as skin, sclera, when jaundice was deepened, urine, expectorant, tear and perspiration be also by xanthochromia, the general invariant color of saliva.
2, the color change of urine and excrement.
3, symptom of digestive tract often has abdominal distention, stomachache, inappetence, feels sick, symptoms such as vomiting, diarrhea or constipation.
4, the performance of cholate mass formed by blood stasis, cardinal symptom has: skin pruritus, bradycardia, abdominal distention, fat are let out, nyctalopia, weak, lethargy and headache etc.
The simultaneous phenomenon of jaundice is:
1, the jaundice heat that occurs together is shown in acute cholangitis, liver abscess, leptospirosis, septicemia, lobar pneumonia.Viral hepatitis or acute haemolysis can have heating jaundice then to occur earlier.
2, jaundice companion upper abdomen has an intense pain and is found in Biliary Calculi, liver abscess or biliary ascariasis; Upper right abdomen have an intense pain, shiver with cold hyperpyrexia and jaundice is the charcot triad, the prompting acute pyogenic cholangitis.Upper right abdomen dull pain of persistence or distending pain are found in chronic cholecystitis, viral hepatitis, liver abscess or primary hepatocarcinoma etc.
3, jaundice companion hepatomegaly, if slightly to moderate swelling, quality soft or medium hardness and smooth surface are shown in viral hepatitis acute biliary infection or biliary obstruction.Obviously the rough and uneven in surface nodosity of enlargement quality rigid surface is shown in constitutional or secondary liver cancer.Not obvious and the quality of hepatomegaly has the lesser tubercle than the whole surface of hard edge, and the person is shown in liver cirrhosis.
Modern medicine often falls flat to clinical a certain symptom treatment, can not find suitable Therapeutic Method; And the traditional Chinese medical science can be utilized the differential diagnosis of diseases and the dialectical principle that combines of treatment jaundice, adopts treating both the principal and secondary aspects of a disease, and deficiency and excess is also controlled; Inside and outside logical the accent; Emergency is taken in concurrently, filters out the natural plant that dampness removing jaundice eliminating, heat-clearing and toxic substances removing, removing heat from blood are had one's ideas straightened out, according to the theory of Chinese medical science prescription; Weight proportion according to certain is prepared from, the Chinese medicine composition of the treatment jaundice of provide evident in efficacy, with low cost, toxic and side effects is minimum.
Like Chinese invention patent publication number CN102335261A, denomination of invention is: " a kind of pharmaceutical composition of treating jaundice and preparation method thereof " discloses a kind of pharmaceutical preparation of treating jaundice.Being specifically related to a kind of is the pharmaceutical composition and the method for preparing of the treatment jaundice processed of raw material with the Chinese herbal medicine.The pharmaceutical composition of said treatment jaundice comprises that following materials of weight proportions medicine is formulated: Herba Artemisiae Scopariae 2-3 part, Herba Lysimachiae 2-3 part, Fructus Gardeniae 1-2 part, Radix Et Rhizoma Rhei 1-2 part, Radix Scutellariae 1-2 part, Poria 1-2 part, Polyporus 1-2 part, Radix Salviae Miltiorrhizae 1-2 part, Radix Paeoniae Rubra 1-3 part.The method of the drug combination preparation of said preparation treatment jaundice comprises the steps: 1) get Herba Artemisiae Scopariae 2-3 part, Herba Lysimachiae 2-3 part, Fructus Gardeniae 1-2 part, Radix Et Rhizoma Rhei 1-2 part, Radix Scutellariae 1-2 part, Poria 1-2 part, Polyporus 1-2 part, Radix Salviae Miltiorrhizae 1-2 part, Radix Paeoniae Rubra 1-3 part; 2), each 1 hour, filter merging filtrate with the step 1) thing decocte with water three times of getting it filled.This kind medicine can be treated jaundice, but can't dialectically execute and control, because jaundice " negative and positive " is divided into two big types promptly: the YANG jaundice of-retention and fumigation of damp-heat inside the body is the YIN jaundice of stagnation of cold-damp in addition; So incomplete place is still arranged.
Summary of the invention
In order to address the above problem, the present invention provides that a kind of quality of the pharmaceutical preparations is stable, determined curative effect, toxic and side effects are low, safe and effective, corresponding treatment partial heat type jaundice, the pharmaceutical composition of wet type jaundice, YIN jaundice (being type of deficiency of both QI and YIN) jaundice partially respectively; It has to improve resistance, reaches the effect of damp eliminating, heat clearing away, jaundice eliminating.
In addition, the present invention also provides this kind preparation of drug combination method.
For reaching above purpose technical scheme of the present invention:
A kind of pharmaceutical composition of treating partial heat type jaundice, pharmaceutical composition of the present invention is to comprise: Herba Veronicastri caulopteri (claim again: the four directions is practiced hard), Herba Artemisiae Scopariae, Herba Rabdosiae Lophanthoidis, Fructus Gardeniae, Radix Et Rhizoma Rhei, Dong Qiancao, Pericarpium Arecae, Cortex Zingiberis, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Radix Ilicis Pubescentis, Herba Hyperici Japonici, Semen Platycladi are spent Herba Clerodendri fortunati, Aloe in vain;
The consumption of each component of medicine of the present invention and proportioning obtain with Test Summary through groping in a large number through the inventor, and each component raw material medicine all has curative effect preferably at the following weight parts ratio range:
4-6 parts of grass, 4-8 parts of Pericarpium Arecae, 4-6 parts of Cortex Zingiberiss, 4-6 parts in Radix Glycyrrhizae, 3-7 parts of Pericarpium Citri Reticulataes, 5-8 parts of Radix Ilicis Pubescentiss, 5-7 parts of Herba Hyperici Japonici, Semen Platycladi are spent 4-6 parts of Herba Clerodendri fortunati, 5-8 parts of Aloes in vain for 5-7 parts before 4-6 parts of Herba Veronicastri caulopteris, 8-14 parts of Herba Artemisiae Scopariaes, 6-10 parts of Herba Rabdosiae Lophanthoidiss, 3-5 parts of Fructus Gardeniae, 7-10 parts of Radix Et Rhizoma Rhei, the east.
Further, preferred each component raw material medicine of pharmaceutical composition of the present invention all has curative effect preferably at the following weight parts ratio range: 6 parts of grass, 7 parts of Pericarpium Arecae, 4 parts of Cortex Zingiberiss, 6 parts in Radix Glycyrrhizae, 7 parts of Pericarpium Citri Reticulataes, 6 parts of Radix Ilicis Pubescentiss, 7 parts of Herba Hyperici Japonici, Semen Platycladi are spent 6 parts of Herba Clerodendri fortunati, 7 parts of Aloes in vain for 7 parts before 5 parts of Herba Veronicastri caulopteris, 10 parts of Herba Artemisiae Scopariaes, 10 parts of Herba Rabdosiae Lophanthoidiss, 4 parts of Fructus Gardeniae, 8 parts of Radix Et Rhizoma Rhei, the east.
A step ground again, a kind of in addition each component raw material medicine of preferred pharmaceutical composition of the present invention all has curative effect preferably at the following weight parts ratio range: careless 4 parts, 8 parts of Pericarpium Arecae, 6 parts of Cortex Zingiberiss, 6 parts in Radix Glycyrrhizae, 6 parts of Pericarpium Citri Reticulataes, 7 parts of Radix Ilicis Pubescentiss, 6 parts of Herba Hyperici Japonici, 6 parts of Semen Platycladi before 4 parts of Herba Veronicastri caulopteris, 14 parts of Herba Artemisiae Scopariaes, 10 parts of Herba Rabdosiae Lophanthoidiss, 5 parts of Fructus Gardeniae, 7 parts of Radix Et Rhizoma Rhei, the east, spend 5 parts of Herba Clerodendri fortunati, 6 parts of Aloes in vain.
A kind of pharmaceutical composition of treating inclined to one side wet type jaundice, pharmaceutical composition of the present invention is to comprise: Rhizoma Atractylodis, Polyporus, Herba Veronicastri caulopteri, Poria, Rhizoma Zingiberis, Herba Rabdosiae Lophanthoidis, Cortex Cinnamomi, the Rhizoma Atractylodis Macrocephalae, Radix Astragali, Radix Angelicae Sinensis, Massa Medicata Fermentata, Pericarpium Citri Reticulatae, Herba Kalimeridis;
The consumption of each component of medicine of the present invention and proportioning obtain with Test Summary through groping in a large number through the inventor, and each component raw material medicine all has curative effect preferably at the following weight parts ratio range:
8-12 parts of Rhizoma Atractylodis, 4-8 parts of Polyporus, 3-5 parts of Herba Veronicastri caulopteris, Poria 6-12 minutes, 3-5 parts of Rhizoma Zingiberiss, 5-8 parts of Herba Rabdosiae Lophanthoidiss, 4-7 parts of Cortex Cinnamomis, 5-15 parts of the Rhizoma Atractylodis Macrocephalaes, 4-15 parts of Radix Astragali, 4-7 parts of Radix Angelicae Sinensis, 5-12 parts of Massa Medicata Fermentatas, 2-6 parts of Pericarpium Citri Reticulataes, 2-6 parts of Herba Kalimeridis.
Further, preferred each component raw material medicine of pharmaceutical composition of the present invention all has curative effect preferably at the following weight parts ratio range: 12 parts of Rhizoma Atractylodis, 8 parts of Polyporus, 5 parts of Herba Veronicastri caulopteris, Poria 10 minutes, 3 parts of Rhizoma Zingiberiss, 8 parts of Herba Rabdosiae Lophanthoidiss, 7 parts of Cortex Cinnamomis, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Radix Astragali, 7 parts of Radix Angelicae Sinensis, 10 parts of Massa Medicata Fermentatas, 4 parts of Pericarpium Citri Reticulataes, 6 parts of Herba Kalimeridis.
A kind of treatment YIN jaundice (be called in the theory of Chinese medical science: the pharmaceutical composition of jaundice deficiency of both QI and YIN), pharmaceutical composition of the present invention is to comprise: 5-12 parts of Radix Codonopsis, 8-14 parts of Radix Astragali, 6-12 parts of the Radixs Polygoni Multiflori, 5-10 parts of the Radix Paeoniae Albas, 4-8 parts of the Rhizoma Atractylodis Macrocephalaes, 8-12 parts in Poria, 4-8 parts of Radix Angelicae Sinensis, 5-10 parts in mountain Cornu Cervi Pantotrichum, 2-8 parts of Folium Artemisiae Argyis, 4-8 parts of Pericarpium Citri Reticulataes, 4-10 parts of Caulis Spatholobis, 6-12 parts of Rhizomadioscoreae;
The consumption of each component of medicine of the present invention and proportioning obtain with Test Summary through groping in a large number through the inventor, and each component raw material medicine all has curative effect preferably at the following weight parts ratio range:
12 parts of Radix Codonopsis, 10 parts of Radix Astragali, 8 parts of the Radixs Polygoni Multiflori, 10 parts of the Radix Paeoniae Albas, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts in Poria, 5 parts of Radix Angelicae Sinensis, 5 parts in mountain Cornu Cervi Pantotrichum, 5 parts of Folium Artemisiae Argyis, 8 parts of Pericarpium Citri Reticulataes, 10 parts of Caulis Spatholobis, 12 parts of Rhizomadioscoreae.
Above medicine of the present invention can be processed any preparation on the pharmaceutics; Preferably process tablet, sugar coated tablet, film coated tablet, enteric coated tablet, suck agent, oral liquid, granule, soft capsule, capsule, electuary, pill, powder, drop pill; The best is processed oral liquid, tablet, capsule, granule, drop pill, soft capsule.
The preparation of the effective ingredient of the described present composition and preparation can adopt following method: one or several Combined application preparations in extraction, water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, the macroreticular resin absorbing method.For example, can these crude drug pulverize mix homogeneously be processed powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is processed oral liquid then; But in order to make each crude drug of this medicine bring into play drug effect better, the present invention preferably adopts following technology to extract to raw material, process pill, oral liquid, tablet, granule, capsule, soft capsule, but this can not limit protection scope of the present invention.
The weight portion proportioning that following effective ingredient extracts raw materials used medicine can be any proportioning, and preferred feedstock medicine weight portion proportioning is a dosage range provided by the present invention.
The method for preparing of the oral liquid of treatment partial heat type jaundice drug composition comprises the steps: among the present invention
A. get 4-6 parts of grass, 4-8 parts of Pericarpium Arecae, 4-6 parts of Cortex Zingiberiss, 4-6 parts in Radix Glycyrrhizae, 3-7 parts of Pericarpium Citri Reticulataes, 5-8 parts of Radix Ilicis Pubescentiss, 5-7 parts of Herba Hyperici Japonici, 5-7 parts of Semen Platycladi before 4-6 parts of Herba Veronicastri caulopteris, 8-14 parts of Herba Artemisiae Scopariaes, 6-10 parts of Herba Rabdosiae Lophanthoidiss, 3-5 parts of Fructus Gardeniae, 7-10 parts of Radix Et Rhizoma Rhei, the east, spend 4-6 parts of Herba Clerodendri fortunati in vain, 5-8 parts of Aloes are subsequent use;
B. the extraction of extractum I: Herba Veronicastri caulopteri, Herba Artemisiae Scopariae add water temperature and soak secondary, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, with 6-10 times of water gaging warm macerating 1 hour, merge infusion for the second time; Herba Rabdosiae Lophanthoidis, Fructus Gardeniae, Radix Et Rhizoma Rhei, Dong Qiancao, Pericarpium Arecae, Cortex Zingiberis, Radix Glycyrrhizae decocting in water secondary boiled 2 hours with 10-15 times of water gaging for the first time, doubly measured with 6-12 for the second time, and decocting in water 2 hours merges water cooking liquid; Pericarpium Citri Reticulatae decocting in water secondary boiled 2 hours with 6-12 times of water gaging for the first time, boiled 2 hours with 3-8 times of water gaging for the second time; Merge above-mentioned warm macerating liquid and water cooking liquid; And Radix Ilicis Pubescentis is added water temperature soak secondary, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, in being filtered in 1 hour with 6-10 times of water gaging warm macerating for the second time; Merging is condensed into cream (surveying relative density 1.2-1.3 for 50 ℃), gets extractum I;
The extraction of extractum II: 1. extract volatile oil: get Herba Hyperici Japonici, Semen Platycladi, spend Herba Clerodendri fortunati in vain, Aloe four Chinese medicine material, merge together, add 1～12 times of water gaging; Soak after 0.5～5 hour; Adopted steam distillation 1～8 hour, and collected volatile oil device preservation in addition, medicinal residues continue to extract; 2. extract: the medicinal residues decocte with water behind extraction such as all the other medical materials and Herba Veronicastri caulopteri, Herba Artemisiae Scopariae medicinal residues and the Herba Veronicastri caulopteri volatile oil 1～3 time, decocted 0.5～3 hour at every turn, collecting decoction filters, and filtrating is concentrated into relative density 1.00～1.35 in the time of 50～80 ℃, puts cold; 3. precipitate with ethanol: add ethanol and make and contain the alcohol amount and reach 10～85%, left standstill 3～48 hours, filter; 4. reclaim ethanol, be concentrated into relative density 1.00～1.45 in the time of 50～90 ℃, get extractum II;
C. dosing: take by weighing extractum I, add water, stir down it was boiled 2～60 minutes, make abundant dissolving, filter; In extractum II, add water and other adjuvant, stir, be heated to 30～80 ℃ and kept 2～30 minutes, filter; In an amount of polysorbate, add volatile oil, be stirred to mix homogeneously, get fragrant solution; With above-mentioned three kinds of combining medicine, add water, stir, heated and boiled 5～50 minutes, put cold, to below 80 ℃, then with medical filtration;
D. fill, gland, 90～150 ℃ of sterilizations of logical then steam 5～60 minutes promptly get oral liquid.
The method for preparing of the oral liquid of the inclined to one side wet type jaundice of treatment comprises the steps: among the present invention
A '. it is subsequent use to get 8-12 parts of Rhizoma Atractylodis, 4-8 parts of Polyporus, 3-5 parts of Herba Veronicastri caulopteris, Poria 6-12 minutes, 3-5 parts of Rhizoma Zingiberiss, 5-8 parts of Herba Rabdosiae Lophanthoidiss, 4-7 parts of Cortex Cinnamomis, 5-15 parts of the Rhizoma Atractylodis Macrocephalaes, 4-15 parts of Radix Astragali, 4-7 parts of Radix Angelicae Sinensis, 5-12 parts of Massa Medicata Fermentatas, 2-6 parts of Pericarpium Citri Reticulataes, 2-6 parts of Herba Kalimeridis;
B '. the extraction of extractum I: Rhizoma Atractylodis, Polyporus, Herba Veronicastri caulopteri add water temperature and soak secondary, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, with 6-10 times of water gaging warm macerating 1 hour, merge infusion for the second time; Poria, Rhizoma Zingiberis, Herba Rabdosiae Lophanthoidis decocting in water secondary boiled 2 hours with 10-15 times of water gaging for the first time, doubly measured with 6-12 for the second time, and decocting in water 2 hours merges water cooking liquid; Cortex Cinnamomi decocting in water secondary boiled 2 hours with 6-12 times of water gaging for the first time, boiled 2 hours with 3-8 times of water gaging for the second time; Merge above-mentioned warm macerating liquid and water cooking liquid; And the Rhizoma Atractylodis Macrocephalae is added water temperature soak secondary, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, in being filtered in 1 hour with 6-10 times of water gaging warm macerating for the second time; Merging is condensed into cream (surveying relative density 1.2-1.3 for 50 ℃), gets extractum I;
The extraction of extractum II: 1. extract volatile oil: get Radix Astragali, Radix Angelicae Sinensis, Massa Medicata Fermentata, Pericarpium Citri Reticulatae, Herba Kalimeridis five tastes medical material, merge together, add 1～12 times of water gaging; Soak after 0.5～5 hour; Adopted steam distillation 1～8 hour, and collected volatile oil device preservation in addition, medicinal residues continue to extract; 2. extract: the medicinal residues decocte with water behind extraction such as all the other medical materials and Rhizoma Atractylodis, Polyporus, Herba Veronicastri caulopteri medicinal residues and the Flos Lonicerae volatile oil 1～3 time; The each decoction 0.5～3 hour, collecting decoction filters; Filtrating is concentrated into relative density 1.00～1.35 in the time of 50～80 ℃, puts cold; 3. precipitate with ethanol: add ethanol and make and contain the alcohol amount and reach 10～85%, left standstill 3～48 hours, filter; 4. reclaim ethanol, be concentrated into relative density 1.00～1.45 in the time of 50～90 ℃, get extractum II;
C '. dosing: take by weighing extractum I, add water, stir down it was boiled 2～60 minutes, make abundant dissolving, filter; In extractum II, add water and other adjuvant, stir, be heated to 30～80 ℃ and kept 2～30 minutes, filter; In an amount of polysorbate, add volatile oil, be stirred to mix homogeneously, get fragrant solution; With above-mentioned three kinds of combining medicine, add water, stir, heated and boiled 5～50 minutes, put cold, to below 80 ℃, then with medical filtration;
D '. fill, gland, 90～150 ℃ of sterilizations of logical then steam 5～60 minutes promptly get oral liquid.
(be called in the theory of Chinese medical science: the method for preparing of the oral liquid of jaundice drug composition deficiency of both QI and YIN) comprises the steps: to treat YIN jaundice among the present invention
A. it is subsequent use to get 5-12 parts of Radix Codonopsis, 8-14 parts of Radix Astragali, 6-12 parts of the Radixs Polygoni Multiflori, 5-10 parts of the Radix Paeoniae Albas, 4-8 parts of the Rhizoma Atractylodis Macrocephalaes, 8-12 parts in Poria, 4-8 parts of Radix Angelicae Sinensis, 5-10 parts in mountain Cornu Cervi Pantotrichum, 2-8 parts of Folium Artemisiae Argyis, 4-8 parts of Pericarpium Citri Reticulataes, 4-10 parts of Caulis Spatholobis, 6-12 parts of Rhizomadioscoreae;
B. the extraction of extractum I: Radix Codonopsis, Radix Astragali, the Radix Polygoni Multiflori, the Radix Paeoniae Alba add water temperature and soak secondary, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, with 6-10 times of water gaging warm macerating 1 hour, merge infusion for the second time; The Rhizoma Atractylodis Macrocephalae, Poria boil secondary, boil 2 hours with 10-15 times of water gaging for the first time, doubly measure with 6-12 for the second time, and decocting in water 2 hours merges water cooking liquid; Radix Angelicae Sinensis decocting in water secondary boiled 2 hours with 6-12 times of water gaging for the first time, boiled 2 hours with 3-8 times of water gaging for the second time; Merge above-mentioned warm macerating liquid and water cooking liquid; And the mountain Cornu Cervi Pantotrichum is added water temperature soak secondary, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, in being filtered in 1 hour with 6-10 times of water gaging warm macerating for the second time; Merging is condensed into cream (surveying relative density 1.2-1.3 for 50 ℃), gets extractum I;
The extraction of extractum II: 1. extract volatile oil: get Folium Artemisiae Argyi, Pericarpium Citri Reticulatae, Caulis Spatholobi, Rhizomadioscoreae four Chinese medicine material, merge together, add 1～12 times of water gaging, soak after 0.5～5 hour, adopted steam distillation 1～8 hour, collect volatile oil device preservation in addition, medicinal residues continue to extract; 2. extract: the medicinal residues decocte with water behind extraction such as all the other medical materials and Radix Codonopsis, Radix Astragali medicinal residues and the mountain Cornu Cervi Pantotrichum volatile oil 1～3 time, decocted 0.5～3 hour at every turn, collecting decoction filters, and filtrating is concentrated into relative density 1.00～1.35 in the time of 50～80 ℃, puts cold; 3. precipitate with ethanol: add ethanol and make and contain the alcohol amount and reach 10～85%, left standstill 3～48 hours, filter; 4. reclaim ethanol, be concentrated into relative density 1.00～1.45 in the time of 50～90 ℃, get extractum II;
C. dosing: take by weighing extractum I, add water, stir down it was boiled 2～60 minutes, make abundant dissolving, filter; In extractum II, add water and other adjuvant, stir, be heated to 30～80 ℃ and kept 2～30 minutes, filter; In an amount of polysorbate, add volatile oil, be stirred to mix homogeneously, get fragrant solution; With above-mentioned three kinds of combining medicine, add water, stir, heated and boiled 5～50 minutes, put cold, to below 80 ℃, then with medical filtration;
D. fill, gland, 90～150 ℃ of sterilizations of logical then steam 5～60 minutes promptly get oral liquid.
More than form when producing and to increase or to reduce according to corresponding ratio; Like large-scale production can be unit with kilogram or with the ton; Small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
Advantage of the present invention and beneficial effect:
Medicine of the present invention adopts not homogeneity, and with different determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, to YANG jaundice treatment, clearing away heat-damp and promoting diuresis is a principle, but the branch of domination of damp pathogen and domination of heat is arranged, and the domination of heat person that wets sees heating, thirsty, abdominal distention constipation, oliguria with yellow urine, red tongue, icteric sclera, wiry and frequent pulse; Tonga simplifies sanction with liver-cleansing yellow-removing, accelerates clearing heat and expelling damp, relieving constipation in conjunction with the medical herbs secret recipe, and the hot person's disease of domination of damp pathogen is seen, and is tired nose heave; Lazyness is sayed, is stayed and receive, feel sick, the dark little Huang of face, and tongue fur is white, moderate pulse; Add and simplify sanction to set upright dampness-eliminating soup,, reach removing dampness heat clearing away jaundice eliminating purpose in conjunction with the medical herbs proved recipe.
The present invention pays attention to organic conception, as sees the disease of liver, does not treat hepatitis merely, is not limited to special side; Special medicine, and execute the method that the heart is made overall plans, the situation of change that its internal organs meridians are direct or indirect is by biochemistry, inhibition and generation; Consider according to the four methods of diagnosis and eight key links comprehensively, join that method is double to be controlled, thereby could the internal organs meridians be the biochemical promotion that becomes then, improve by bad by restraint; Become reason by disorder and control, just have good hope, this project therapy dare to be innovated, treating the same disease with different methods; On the conventional formulation basis, increase the medical herbs secret recipe,, reach damp eliminating, heat clearing away, jaundice eliminating to improve resistance, evident in efficacy.
The present invention had both treated primary symptom, treated hold concurrently disease or complication again, strengthening vital QI to eliminate pathogenic factors, and treating both the principal and secondary aspects of a disease is used for treatment, and curative effect is faster and better, often can get instant result.Can be used for the emergency treatment first aid, also can be used for general out patient service or clinic, pharmacy or home-use subsequent use medicine.Being widely used, really is good side's good medicine.
The specific embodiment
A kind of pharmaceutical composition of treating partial heat type jaundice, pharmaceutical composition of the present invention is to comprise: Herba Veronicastri caulopteri (claim again: the four directions is practiced hard), Herba Artemisiae Scopariae, Herba Rabdosiae Lophanthoidis, Fructus Gardeniae, Radix Et Rhizoma Rhei, Dong Qiancao, Pericarpium Arecae, Cortex Zingiberis, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Radix Ilicis Pubescentis, Herba Hyperici Japonici, Semen Platycladi are spent Herba Clerodendri fortunati, Aloe in vain;
The consumption of each component of medicine of the present invention and proportioning obtain with Test Summary through groping in a large number through the inventor, and each component raw material medicine all has curative effect preferably at the following weight parts ratio range:
4-6 parts of grass, 4-8 parts of Pericarpium Arecae, 4-6 parts of Cortex Zingiberiss, 4-6 parts in Radix Glycyrrhizae, 3-7 parts of Pericarpium Citri Reticulataes, 5-8 parts of Radix Ilicis Pubescentiss, 5-7 parts of Herba Hyperici Japonici, Semen Platycladi are spent 4-6 parts of Herba Clerodendri fortunati, 5-8 parts of Aloes in vain for 5-7 parts before 4-6 parts of Herba Veronicastri caulopteris, 8-14 parts of Herba Artemisiae Scopariaes, 6-10 parts of Herba Rabdosiae Lophanthoidiss, 3-5 parts of Fructus Gardeniae, 7-10 parts of Radix Et Rhizoma Rhei, the east.
Preferred each component raw material medicine of pharmaceutical composition of the present invention all has curative effect preferably at the following weight parts ratio range: 6 parts of grass, 7 parts of Pericarpium Arecae, 4 parts of Cortex Zingiberiss, 6 parts in Radix Glycyrrhizae, 7 parts of Pericarpium Citri Reticulataes, 6 parts of Radix Ilicis Pubescentiss, 7 parts of Herba Hyperici Japonici, Semen Platycladi are spent 6 parts of Herba Clerodendri fortunati, 7 parts of Aloes in vain for 7 parts before 5 parts of Herba Veronicastri caulopteris, 10 parts of Herba Artemisiae Scopariaes, 10 parts of Herba Rabdosiae Lophanthoidiss, 4 parts of Fructus Gardeniae, 8 parts of Radix Et Rhizoma Rhei, the east.
A kind of in addition each component raw material medicine of preferred pharmaceutical composition of the present invention all has curative effect preferably at the following weight parts ratio range: careless 4 parts, 8 parts of Pericarpium Arecae, 6 parts of Cortex Zingiberiss, 6 parts in Radix Glycyrrhizae, 6 parts of Pericarpium Citri Reticulataes, 7 parts of Radix Ilicis Pubescentiss, 6 parts of Herba Hyperici Japonici, 6 parts of Semen Platycladi before 4 parts of Herba Veronicastri caulopteris, 14 parts of Herba Artemisiae Scopariaes, 10 parts of Herba Rabdosiae Lophanthoidiss, 5 parts of Fructus Gardeniae, 7 parts of Radix Et Rhizoma Rhei, the east, spend 5 parts of Herba Clerodendri fortunati, 6 parts of Aloes in vain.
A kind of pharmaceutical composition of treating inclined to one side wet type jaundice, pharmaceutical composition of the present invention is to comprise: Rhizoma Atractylodis, Polyporus, Herba Veronicastri caulopteri, Poria, Rhizoma Zingiberis, Herba Rabdosiae Lophanthoidis, Cortex Cinnamomi, the Rhizoma Atractylodis Macrocephalae, Radix Astragali, Radix Angelicae Sinensis, Massa Medicata Fermentata, Pericarpium Citri Reticulatae, Herba Kalimeridis;
The consumption of each component of medicine of the present invention and proportioning obtain with Test Summary through groping in a large number through the inventor, and each component raw material medicine all has curative effect preferably at the following weight parts ratio range:
8-12 parts of Rhizoma Atractylodis, 4-8 parts of Polyporus, 3-5 parts of Herba Veronicastri caulopteris, Poria 6-12 minutes, 3-5 parts of Rhizoma Zingiberiss, 5-8 parts of Herba Rabdosiae Lophanthoidiss, 4-7 parts of Cortex Cinnamomis, 5-15 parts of the Rhizoma Atractylodis Macrocephalaes, 4-15 parts of Radix Astragali, 4-7 parts of Radix Angelicae Sinensis, 5-12 parts of Massa Medicata Fermentatas, 2-6 parts of Pericarpium Citri Reticulataes, 2-6 parts of Herba Kalimeridis.
Further, preferred each component raw material medicine of pharmaceutical composition of the present invention all has curative effect preferably at the following weight parts ratio range: 12 parts of Rhizoma Atractylodis, 8 parts of Polyporus, 5 parts of Herba Veronicastri caulopteris, Poria 10 minutes, 3 parts of Rhizoma Zingiberiss, 8 parts of Herba Rabdosiae Lophanthoidiss, 7 parts of Cortex Cinnamomis, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Radix Astragali, 7 parts of Radix Angelicae Sinensis, 10 parts of Massa Medicata Fermentatas, 4 parts of Pericarpium Citri Reticulataes, 6 parts of Herba Kalimeridis.
A kind of treatment YIN jaundice (be called in the theory of Chinese medical science: the pharmaceutical composition of jaundice deficiency of both QI and YIN), pharmaceutical composition of the present invention is to comprise: 5-12 parts of Radix Codonopsis, 8-14 parts of Radix Astragali, 6-12 parts of the Radixs Polygoni Multiflori, 5-10 parts of the Radix Paeoniae Albas, 4-8 parts of the Rhizoma Atractylodis Macrocephalaes, 8-12 parts in Poria, 4-8 parts of Radix Angelicae Sinensis, 5-10 parts in mountain Cornu Cervi Pantotrichum, 2-8 parts of Folium Artemisiae Argyis, 4-8 parts of Pericarpium Citri Reticulataes, 4-10 parts of Caulis Spatholobis, 6-12 parts of Rhizomadioscoreae;
The consumption of each component of medicine of the present invention and proportioning obtain with Test Summary through groping in a large number through the inventor, and each component raw material medicine all has curative effect preferably at the following weight parts ratio range:
12 parts of Radix Codonopsis, 10 parts of Radix Astragali, 8 parts of the Radixs Polygoni Multiflori, 10 parts of the Radix Paeoniae Albas, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts in Poria, 5 parts of Radix Angelicae Sinensis, 5 parts in mountain Cornu Cervi Pantotrichum, 5 parts of Folium Artemisiae Argyis, 8 parts of Pericarpium Citri Reticulataes, 10 parts of Caulis Spatholobis, 12 parts of Rhizomadioscoreae.
Medicine of the present invention can be processed any preparation on the pharmaceutics; Preferably process tablet, sugar coated tablet, film coated tablet, enteric coated tablet, suck agent, oral liquid, granule, soft capsule, capsule, electuary, pill, powder, drop pill; The best is processed oral liquid, tablet, capsule, granule, drop pill, soft capsule.
The preparation of the effective ingredient of the described present composition and preparation can adopt following method: one or several Combined application preparations in extraction, water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, the macroreticular resin absorbing method.For example, can these crude drug pulverize mix homogeneously be processed powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is processed oral liquid then; But in order to make each crude drug of this medicine bring into play drug effect better, the present invention preferably adopts following technology to extract to raw material, process pill, oral liquid, tablet, granule, capsule, soft capsule, but this can not limit protection scope of the present invention.
The weight portion proportioning that following effective ingredient extracts raw materials used medicine can be any proportioning, and preferred feedstock medicine weight portion proportioning is a dosage range provided by the present invention.
The method for preparing of the oral liquid of Chinese medicine composition of the present invention comprises the steps:
The method for preparing of the oral liquid of treatment partial heat type jaundice drug composition comprises the steps: among the present invention
A. get 4-6 parts of grass, 4-8 parts of Pericarpium Arecae, 4-6 parts of Cortex Zingiberiss, 4-6 parts in Radix Glycyrrhizae, 3-7 parts of Pericarpium Citri Reticulataes, 5-8 parts of Radix Ilicis Pubescentiss, 5-7 parts of Herba Hyperici Japonici, 5-7 parts of Semen Platycladi before 4-6 parts of Herba Veronicastri caulopteris, 8-14 parts of Herba Artemisiae Scopariaes, 6-10 parts of Herba Rabdosiae Lophanthoidiss, 3-5 parts of Fructus Gardeniae, 7-10 parts of Radix Et Rhizoma Rhei, the east, spend 4-6 parts of Herba Clerodendri fortunati in vain, 5-8 parts of Aloes are subsequent use;
B. the extraction of extractum I: Herba Veronicastri caulopteri, Herba Artemisiae Scopariae add water temperature and soak secondary, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, with 6-10 times of water gaging warm macerating 1 hour, merge infusion for the second time; Herba Rabdosiae Lophanthoidis, Fructus Gardeniae, Radix Et Rhizoma Rhei, Dong Qiancao, Pericarpium Arecae, Cortex Zingiberis, Radix Glycyrrhizae decocting in water secondary boiled 2 hours with 10-15 times of water gaging for the first time, doubly measured with 6-12 for the second time, and decocting in water 2 hours merges water cooking liquid; Pericarpium Citri Reticulatae decocting in water secondary boiled 2 hours with 6-12 times of water gaging for the first time, boiled 2 hours with 3-8 times of water gaging for the second time; Merge above-mentioned warm macerating liquid and water cooking liquid; And Radix Ilicis Pubescentis is added water temperature soak secondary, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, in being filtered in 1 hour with 6-10 times of water gaging warm macerating for the second time; Merging is condensed into cream (surveying relative density 1.2-1.3 for 50 ℃), gets extractum I;
The extraction of extractum II: 1. extract volatile oil: get Herba Hyperici Japonici, Semen Platycladi, spend Herba Clerodendri fortunati in vain, Aloe four Chinese medicine material, merge together, add 1～12 times of water gaging; Soak after 0.5～5 hour; Adopted steam distillation 1～8 hour, and collected volatile oil device preservation in addition, medicinal residues continue to extract; 2. extract: the medicinal residues decocte with water behind extraction such as all the other medical materials and Herba Veronicastri caulopteri, Herba Artemisiae Scopariae medicinal residues and the Herba Veronicastri caulopteri volatile oil 1～3 time, decocted 0.5～3 hour at every turn, collecting decoction filters, and filtrating is concentrated into relative density 1.00～1.35 in the time of 50～80 ℃, puts cold; 3. precipitate with ethanol: add ethanol and make and contain the alcohol amount and reach 10～85%, left standstill 3～48 hours, filter; 4. reclaim ethanol, be concentrated into relative density 1.00～1.45 in the time of 50～90 ℃, get extractum II;
C. dosing: take by weighing extractum I, add water, stir down it was boiled 2～60 minutes, make abundant dissolving, filter; In extractum II, add water and other adjuvant, stir, be heated to 30～80 ℃ and kept 2～30 minutes, filter; In an amount of polysorbate, add volatile oil, be stirred to mix homogeneously, get fragrant solution; With above-mentioned three kinds of combining medicine, add water, stir, heated and boiled 5～50 minutes, put cold, to below 80 ℃, then with medical filtration;
D. fill, gland, 90～150 ℃ of sterilizations of logical then steam 5～60 minutes promptly get oral liquid.
The method for preparing of the oral liquid of the inclined to one side wet type jaundice of treatment comprises the steps: among the present invention
A '. it is subsequent use to get 8-12 parts of Rhizoma Atractylodis, 4-8 parts of Polyporus, 3-5 parts of Herba Veronicastri caulopteris, Poria 6-12 minutes, 3-5 parts of Rhizoma Zingiberiss, 5-8 parts of Herba Rabdosiae Lophanthoidiss, 4-7 parts of Cortex Cinnamomis, 5-15 parts of the Rhizoma Atractylodis Macrocephalaes, 4-15 parts of Radix Astragali, 4-7 parts of Radix Angelicae Sinensis, 5-12 parts of Massa Medicata Fermentatas, 2-6 parts of Pericarpium Citri Reticulataes, 2-6 parts of Herba Kalimeridis;
B '. the extraction of extractum I: Rhizoma Atractylodis, Polyporus, Herba Veronicastri caulopteri add water temperature and soak secondary, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, with 6-10 times of water gaging warm macerating 1 hour, merge infusion for the second time; Poria, Rhizoma Zingiberis, Herba Rabdosiae Lophanthoidis decocting in water secondary boiled 2 hours with 10-15 times of water gaging for the first time, doubly measured with 6-12 for the second time, and decocting in water 2 hours merges water cooking liquid; Cortex Cinnamomi decocting in water secondary boiled 2 hours with 6-12 times of water gaging for the first time, boiled 2 hours with 3-8 times of water gaging for the second time; Merge above-mentioned warm macerating liquid and water cooking liquid; And the Rhizoma Atractylodis Macrocephalae is added water temperature soak secondary, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, in being filtered in 1 hour with 6-10 times of water gaging warm macerating for the second time; Merging is condensed into cream (surveying relative density 1.2-1.3 for 50 ℃), gets extractum I;
The extraction of extractum II: 1. extract volatile oil: get Radix Astragali, Radix Angelicae Sinensis, Massa Medicata Fermentata, Pericarpium Citri Reticulatae, Herba Kalimeridis five tastes medical material, merge together, add 1～12 times of water gaging; Soak after 0.5～5 hour; Adopted steam distillation 1～8 hour, and collected volatile oil device preservation in addition, medicinal residues continue to extract; 2. extract: the medicinal residues decocte with water behind extraction such as all the other medical materials and Rhizoma Atractylodis, Polyporus, Herba Veronicastri caulopteri medicinal residues and the Flos Lonicerae volatile oil 1～3 time; The each decoction 0.5～3 hour, collecting decoction filters; Filtrating is concentrated into relative density 1.00～1.35 in the time of 50～80 ℃, puts cold; 3. precipitate with ethanol: add ethanol and make and contain the alcohol amount and reach 10～85%, left standstill 3～48 hours, filter; 4. reclaim ethanol, be concentrated into relative density 1.00～1.45 in the time of 50～90 ℃, get extractum II;
C '. dosing: take by weighing extractum I, add water, stir down it was boiled 2～60 minutes, make abundant dissolving, filter; In extractum II, add water and other adjuvant, stir, be heated to 30～80 ℃ and kept 2～30 minutes, filter; In an amount of polysorbate, add volatile oil, be stirred to mix homogeneously, get fragrant solution; With above-mentioned three kinds of combining medicine, add water, stir, heated and boiled 5～50 minutes, put cold, to below 80 ℃, then with medical filtration;
D '. fill, gland, 90～150 ℃ of sterilizations of logical then steam 5～60 minutes promptly get oral liquid.
(be called in the theory of Chinese medical science: the method for preparing of the oral liquid of jaundice drug composition deficiency of both QI and YIN) comprises the steps: to treat YIN jaundice among the present invention
A. it is subsequent use to get 5-12 parts of Radix Codonopsis, 8-14 parts of Radix Astragali, 6-12 parts of the Radixs Polygoni Multiflori, 5-10 parts of the Radix Paeoniae Albas, 4-8 parts of the Rhizoma Atractylodis Macrocephalaes, 8-12 parts in Poria, 4-8 parts of Radix Angelicae Sinensis, 5-10 parts in mountain Cornu Cervi Pantotrichum, 2-8 parts of Folium Artemisiae Argyis, 4-8 parts of Pericarpium Citri Reticulataes, 4-10 parts of Caulis Spatholobis, 6-12 parts of Rhizomadioscoreae;
B. the extraction of extractum I: Radix Codonopsis, Radix Astragali, the Radix Polygoni Multiflori, the Radix Paeoniae Alba add water temperature and soak secondary, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, with 6-10 times of water gaging warm macerating 1 hour, merge infusion for the second time; The Rhizoma Atractylodis Macrocephalae, Poria boil secondary, boil 2 hours with 10-15 times of water gaging for the first time, doubly measure with 6-12 for the second time, and decocting in water 2 hours merges water cooking liquid; Radix Angelicae Sinensis decocting in water secondary boiled 2 hours with 6-12 times of water gaging for the first time, boiled 2 hours with 3-8 times of water gaging for the second time; Merge above-mentioned warm macerating liquid and water cooking liquid; And the mountain Cornu Cervi Pantotrichum is added water temperature soak secondary, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, in being filtered in 1 hour with 6-10 times of water gaging warm macerating for the second time; Merging is condensed into cream (surveying relative density 1.2-1.3 for 50 ℃), gets extractum I;
The extraction of extractum II: 1. extract volatile oil: get Folium Artemisiae Argyi, Pericarpium Citri Reticulatae, Caulis Spatholobi, Rhizomadioscoreae four Chinese medicine material, merge together, add 1～12 times of water gaging, soak after 0.5～5 hour, adopted steam distillation 1～8 hour, collect volatile oil device preservation in addition, medicinal residues continue to extract; 2. extract: the medicinal residues decocte with water behind extraction such as all the other medical materials and Radix Codonopsis, Radix Astragali medicinal residues and the mountain Cornu Cervi Pantotrichum volatile oil 1～3 time, decocted 0.5～3 hour at every turn, collecting decoction filters, and filtrating is concentrated into relative density 1.00～1.35 in the time of 50～80 ℃, puts cold; 3. precipitate with ethanol: add ethanol and make and contain the alcohol amount and reach 10～85%, left standstill 3～48 hours, filter; 4. reclaim ethanol, be concentrated into relative density 1.00～1.45 in the time of 50～90 ℃, get extractum II;
C. dosing: take by weighing extractum I, add water, stir down it was boiled 2～60 minutes, make abundant dissolving, filter; In extractum II, add water and other adjuvant, stir, be heated to 30～80 ℃ and kept 2～30 minutes, filter; In an amount of polysorbate, add volatile oil, be stirred to mix homogeneously, get fragrant solution; With above-mentioned three kinds of combining medicine, add water, stir, heated and boiled 5～50 minutes, put cold, to below 80 ℃, then with medical filtration;
D. fill, gland, 90～150 ℃ of sterilizations of logical then steam 5～60 minutes promptly get oral liquid.
More than form when producing and to increase or to reduce according to corresponding ratio; Like large-scale production can be unit with kilogram or with the ton; Small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
Certainly; The pharmaceutical composition of treatment jaundice of the present invention also can adopt traditional method: place the medicine of above composition in the clean marmite, add clean drinking water, 3-5 centimetre of submergence medicine; Soak after 15-20 minute, the slow fire heating changes intense fire after 3-5 minute and boils.From the timing of when boiling and use slow fire instead and continued to boil 45 minutes to one hour, during can add boiling water inadequately like moisture, after the time arrives, filter and remove residue, the acquisition medicinal liquid, natural cooling.
Weight portion in this specific embodiment all is adopted as metric unit: gram.
The drug combination preparation of treatment jaundice of the present invention; When being prepared into medicament, can add the medicine acceptable auxiliary; Described acceptable accessories comprises diluent, filler (like mannitol, lactose, Polyethylene Glycol) conventional in the preparation, binding agent (starch, microcrystalline Cellulose); Disintegrating agent (like carboxymethyl cellulose, low substituted hydroxypropyl cellulose); Lubricant (like Pulvis Talci, magnesium stearate), wetting agent (like propylene glycol, ethanol), stabilizing agent (EDTA-2Na, sodium thiosulfate, sodium pyrosulfite, sodium sulfite, ethanolamine, sodium bicarbonate, nicotiamide) or the like.Above-mentioned adjuvant can be a common dose, mixes with the main constituent extract with proportioning commonly used, and after main constituent extract consumption was confirmed, the proportioning between each pharmaceutic adjuvant can suitably be regulated as required.
Below, the medicine analysis of pharmacodynamics side and the clinical efficacy experiment of treating the pharmaceutical composition of jaundice through the present invention further specify good effect of the present invention.
Wherein, the drug regimen object space of treatment partial heat type jaundice is separated:
Herba Veronicastri caulopteri, Herba Artemisiae Scopariae, Herba Rabdosiae Lophanthoidis; Fructus Gardeniae can damp eliminating, the effect of heat clearing away, detoxifcation, jaundice eliminating be monarch, Radix Et Rhizoma Rhei, Radix Ilicis Pubescentis, Herba Hyperici Japonici, Semen Platycladi, Aloe etc. have dampness, heat clearing away, removing heat from blood, toxin expelling, make damp and hot from stool discharge: Dong Qiancao,
Pericarpium Arecae, Cortex Zingiberis, spend Herba Clerodendri fortunati in vain and have liver heat removing, toxin expelling, circulation of qi promoting, diuretic, separate steam, dirty long-pending toxin discharges from urine, Radix Glycyrrhizae has the priming focus of clearing the way and renders a service for making it: above yellow cellulitis YANG jaundice partial heat type scientific formula ability clearing heat and expelling damp, detoxifcation,
Resolving functions to reach liver heat removing, eliminating pathogen in the liver, damp eliminating heat, toxin expelling, quick damp eliminating heat, makes two just can lead to soothing the liver recovering liver function; Yellow cellulitis Lock-out, recovery from illness, 886 routine patient's cure rates 9 2.6%; Though all the other patients do not fully recover, disease takes a turn for the better gradually, alleviates, up to recovery from illness.
Treating the drug regimen object space of inclined to one side wet type jaundice separates: ability damp eliminating heat clearing away toxin expelling jaundice eliminating is practiced hard in Herba Rabdosiae Lophanthoidis, Rhizoma Atractylodis, Polyporus, four directions; Poria, Rhizoma Zingiberis, Cortex Cinnamomi, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Radix Astragali; Can hot wet activate yang, hold up the moon, help gasification, invigorating primordial QI, invigorate blood circulation; Accent reaches the adjuvant drug of liver spleen organ, and Herba Kalimeridis, Massa Medicata Fermentata, Pericarpium Citri Reticulatae, theory of Chinese medical science are seen disease, the knowing the liver disease will be transmitted into the spleen of liver, and tonifying the spleen impels liver-yin rising tone weighing apparatus in the ban; Add Radix Glycyrrhizae and reach focus, disease must be removed for making priming. get well.
The treatment YIN jaundice (be called in the theory of Chinese medical science: deficiency of both QI and YIN) the drug regimen object space of jaundice is separated:
Spleen invigorating is monarch in the QI invigorating benefits such as Radix Codonopsis, Radix Astragali, Folium Artemisiae Argyi, Rhizomadioscoreae: the Radix Polygoni Multiflori, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Caulis Spatholobi, Radix Angelicae Sinensis, can be minister to consolidate the nourishing liver-YIN of getting rid of evils, Poria, Pericarpium Citri Reticulatae, mountain Cornu Cervi Pantotrichum etc. be assistant, and with the damp eliminating circulation of qi promoting, gas is capable, and blood is then gone, and changes
Kind blood circulation makes equilibrium between yin and yang, and sun is given birth to then cloudy long, and the long then fire of sun dissipates from diving, and sick good naturally, this therapy truly has unique distinction, and it is few to spend, and curative effect is high, short treating period, and especially medical herbs is welcome by the patient deeply.
All medicines of the present invention, the dosage 1-3 of every flavor medicine gram are applicable to 1-3 year child, but Semen Armeniacae Amarum is slightly poisonous, and 1-3 year child should not use or careful usefulness, as using, please instructs down the doctor and uses.Clear thinking of the present invention, compatibility is tight accurately, and any Herba indigoferae Pseudotinctoriae all can not lack, and lacking simply then curative effect will have a greatly reduced quality.
Typical case's case history:
Case 1.
Chen, the man, 47 years old, patient's calling, disease is seen, heating is thirsty, icteric sclera, all skin turning yellow, oliguria is helvolus, stool, abdominal distention, tongue fur is red, wiry and frequent pulse, liver helps down, 2CM, spleen.Body temperature 39.2.C, liver function: icteric index 18u, pyruvic transaminase 98u, due to illness Lu Geer iodine test solely test 16 u weighs and is in hospital.
Dialectical: YANG jaundice, partial heat type.
The rule of treatment: liver heat removing gallbladder damp eliminating heat, Huang disappears;
The pharmaceutical composition of the treatment jaundice of using is: 6 parts of grass, 7 parts of Pericarpium Arecae, 4 parts of Cortex Zingiberiss, 6 parts in Radix Glycyrrhizae, 7 parts of Pericarpium Citri Reticulataes, 6 parts of Radix Ilicis Pubescentiss, 7 parts of Herba Hyperici Japonici, 7 parts of Semen Platycladi before 5 parts of Herba Veronicastri caulopteris, 10 parts of Herba Artemisiae Scopariaes, 10 parts of Herba Rabdosiae Lophanthoidiss, 4 parts of Fructus Gardeniae, 8 parts of Radix Et Rhizoma Rhei, the east, spend 6 parts of Herba Clerodendri fortunati, 7 parts of Aloes in vain.
Three doses, decoction, every day twice, sooner or later respectively once, cool clothes.
Curative effect: use this pharmaceutical composition, each 20 every day 3 times, taking medicine after meal, first course of treatment, its disease is taken a turn for the better, and with second course of treatment of disease clothes, patient's heat is moved back, and Huang moves back, and appetite is good slightly.The third course, the spirit of good, all symptoms disappeared, normal liver function tests, jaundice index 4u, Lu Song children iodine test (a) brain floc test (a) single test 7u, discharged.
Case 2.
Zhang, the man, 52 years old, the patient comes institute to go to a doctor: disease is seen lack of appetite, and was uncomfortable in chest, uncomfortable under the both sides of the chest, tired, half congealed sometimes wet during stool, yellowish or reddish urine, the little Huang of the order and the whole body, thick fur is greasy, stringy and rolling pulse, 2.5cm under the liver rib, spleen (+), body temperature 38.4.C, liver function icteric index 21u, the Lu Geer iodine test, the turbid test of Moschus moschiferous 15u, the brain wadding (+++), transaminase 86u, card is seen.
Diagnosis: the inclined to one side wet type of YANG jaundice,
Rule: dampness removing, heat clearing away, jaundice eliminating,
The pharmaceutical composition of the treatment jaundice of using is: 12 parts of Rhizoma Atractylodis, 8 parts of Polyporus, 5 parts of Herba Veronicastri caulopteris, Poria 10 minutes, 3 parts of Rhizoma Zingiberiss, 8 parts of Herba Rabdosiae Lophanthoidiss, 7 parts of Cortex Cinnamomis, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Radix Astragali, 7 parts of Radix Angelicae Sinensis, 10 parts of Massa Medicata Fermentatas, 4 parts of Pericarpium Citri Reticulataes, 6 parts of Herba Kalimeridis.
Three doses, decoction, every day potion, sooner or later each once, cool clothes;
After the preferred embodiment that specifies; Being familiar with this technological personage can be well understood to; Do not break away from above-mentioned claim with spirit under can carry out various variations and modification; All foundations technical spirit of the present invention all belongs to the scope of technical scheme of the present invention to any simple modification, equivalent variations and modification that above embodiment did.And the embodiment that the present invention also is not subject in the description to be given an actual example.
Claims (10)
1. pharmaceutical composition of treating jaundice; It is characterized in that it is to be processed by following raw materials in weight portion medicine: 4-6 parts of grass, 4-8 parts of Pericarpium Arecae, 4-6 parts of Cortex Zingiberiss, 4-6 parts in Radix Glycyrrhizae, 3-7 parts of Pericarpium Citri Reticulataes, 5-8 parts of Radix Ilicis Pubescentiss, 5-7 parts of Herba Hyperici Japonici, Semen Platycladi are spent 4-6 parts of Herba Clerodendri fortunati, 5-8 parts of Aloes in vain for 5-7 parts before 4-6 parts of Herba Veronicastri caulopteris, 8-14 parts of Herba Artemisiae Scopariaes, 6-10 parts of Herba Rabdosiae Lophanthoidiss, 3-5 parts of Fructus Gardeniae, 7-10 parts of Radix Et Rhizoma Rhei, the east.
2. treat the pharmaceutical composition of jaundice according to claim 1; It is characterized in that it is to be processed by following raw materials in weight portion medicine: 6 parts of grass, 7 parts of Pericarpium Arecae, 4 parts of Cortex Zingiberiss, 6 parts in Radix Glycyrrhizae, 7 parts of Pericarpium Citri Reticulataes, 6 parts of Radix Ilicis Pubescentiss, 7 parts of Herba Hyperici Japonici, Semen Platycladi are spent 6 parts of Herba Clerodendri fortunati, 7 parts of Aloes in vain for 7 parts before 5 parts of Herba Veronicastri caulopteris, 10 parts of Herba Artemisiae Scopariaes, 10 parts of Herba Rabdosiae Lophanthoidiss, 4 parts of Fructus Gardeniae, 8 parts of Radix Et Rhizoma Rhei, the east.
3. treat the pharmaceutical composition of jaundice according to claim 1; It is characterized in that it is to be processed by following raw materials in weight portion medicine: 4 parts of grass, 8 parts of Pericarpium Arecae, 6 parts of Cortex Zingiberiss, 6 parts in Radix Glycyrrhizae, 6 parts of Pericarpium Citri Reticulataes, 7 parts of Radix Ilicis Pubescentiss, 6 parts of Herba Hyperici Japonici, 6 parts of Semen Platycladi before 4 parts of Herba Veronicastri caulopteris, 14 parts of Herba Artemisiae Scopariaes, 10 parts of Herba Rabdosiae Lophanthoidiss, 5 parts of Fructus Gardeniae, 7 parts of Radix Et Rhizoma Rhei, the east, spend 5 parts of Herba Clerodendri fortunati, 6 parts of Aloes in vain.
One kind the treatment inclined to one side wet type jaundice pharmaceutical composition; It is characterized in that it is to be processed by following raw materials in weight portion medicine: 8-12 parts of Rhizoma Atractylodis, 4-8 parts of Polyporus, 3-5 parts of Herba Veronicastri caulopteris, Poria 6-12 minutes, 3-5 parts of Rhizoma Zingiberiss, 5-8 parts of Herba Rabdosiae Lophanthoidiss, 4-7 parts of Cortex Cinnamomis, 5-15 parts of the Rhizoma Atractylodis Macrocephalaes, 4-15 parts of Radix Astragali, 4-7 parts of Radix Angelicae Sinensis, 5-12 parts of Massa Medicata Fermentatas, 2-6 parts of Pericarpium Citri Reticulataes, 2-6 parts of Herba Kalimeridis.
5. like the pharmaceutical composition of the said treatment jaundice of claim 4; It is characterized in that it is to be processed by following raw materials in weight portion medicine: 12 parts of Rhizoma Atractylodis, 8 parts of Polyporus, 5 parts of Herba Veronicastri caulopteris, Poria 10 minutes, 3 parts of Rhizoma Zingiberiss, 8 parts of Herba Rabdosiae Lophanthoidiss, 7 parts of Cortex Cinnamomis, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Radix Astragali, 7 parts of Radix Angelicae Sinensis, 10 parts of Massa Medicata Fermentatas, 4 parts of Pericarpium Citri Reticulataes, 6 parts of Herba Kalimeridis.
6. pharmaceutical composition of treating the YIN jaundice jaundice; It is characterized in that it is to be processed by following raw materials in weight portion medicine: 5-12 parts of Radix Codonopsis, 8-14 parts of Radix Astragali, 6-12 parts of the Radixs Polygoni Multiflori, 5-10 parts of the Radix Paeoniae Albas, 4-8 parts of the Rhizoma Atractylodis Macrocephalaes, 8-12 parts in Poria, 4-8 parts of Radix Angelicae Sinensis, 5-10 parts in mountain Cornu Cervi Pantotrichum, 2-8 parts of Folium Artemisiae Argyis, 4-8 parts of Pericarpium Citri Reticulataes, 4-10 parts of Caulis Spatholobis, 6-12 parts of Rhizomadioscoreae.
7. like the pharmaceutical composition of the said treatment jaundice of claim 6; It is characterized in that it is to be processed by following raw materials in weight portion medicine: 12 parts of Radix Codonopsis, 10 parts of Radix Astragali, 8 parts of the Radixs Polygoni Multiflori, 10 parts of the Radix Paeoniae Albas, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts in Poria, 5 parts of Radix Angelicae Sinensis, 5 parts in mountain Cornu Cervi Pantotrichum, 5 parts of Folium Artemisiae Argyis, 8 parts of Pericarpium Citri Reticulataes, 10 parts of Caulis Spatholobis, 12 parts of Rhizomadioscoreae.
8. the method for preparing of the oral liquid of the pharmaceutical composition of a treatment jaundice as claimed in claim 1 comprises the steps:
A. get 4-6 parts of grass, 4-8 parts of Pericarpium Arecae, 4-6 parts of Cortex Zingiberiss, 4-6 parts in Radix Glycyrrhizae, 3-7 parts of Pericarpium Citri Reticulataes, 5-8 parts of Radix Ilicis Pubescentiss, 5-7 parts of Herba Hyperici Japonici, 5-7 parts of Semen Platycladi before 4-6 parts of Herba Veronicastri caulopteris, 8-14 parts of Herba Artemisiae Scopariaes, 6-10 parts of Herba Rabdosiae Lophanthoidiss, 3-5 parts of Fructus Gardeniae, 7-10 parts of Radix Et Rhizoma Rhei, the east, spend 4-6 parts of Herba Clerodendri fortunati in vain, 5-8 parts of Aloes are subsequent use;
B. the extraction of extractum I: Herba Veronicastri caulopteri, Herba Artemisiae Scopariae add water temperature and soak secondary, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, with 6-10 times of water gaging warm macerating 1 hour, merge infusion for the second time; Herba Rabdosiae Lophanthoidis, Fructus Gardeniae, Radix Et Rhizoma Rhei, Dong Qiancao, Pericarpium Arecae, Cortex Zingiberis, Radix Glycyrrhizae decocting in water secondary boiled 2 hours with 10-15 times of water gaging for the first time, doubly measured with 6-12 for the second time, and decocting in water 2 hours merges water cooking liquid; Pericarpium Citri Reticulatae decocting in water secondary boiled 2 hours with 6-12 times of water gaging for the first time, boiled 2 hours with 3-8 times of water gaging for the second time; Merge above-mentioned warm macerating liquid and water cooking liquid; And Radix Ilicis Pubescentis is added water temperature soak secondary, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, in being filtered in 1 hour with 6-10 times of water gaging warm macerating for the second time; Merging is condensed into cream (surveying relative density 1.2-1.3 for 50 ℃), gets extractum I;
The extraction of extractum II: 1. extract volatile oil: get Herba Hyperici Japonici, Semen Platycladi, spend Herba Clerodendri fortunati in vain, Aloe four Chinese medicine material, merge together, add 1～12 times of water gaging; Soak after 0.5～5 hour; Adopted steam distillation 1～8 hour, and collected volatile oil device preservation in addition, medicinal residues continue to extract; 2. extract: the medicinal residues decocte with water behind extraction such as all the other medical materials and Herba Veronicastri caulopteri, Herba Artemisiae Scopariae medicinal residues and the Herba Veronicastri caulopteri volatile oil 1～3 time, decocted 0.5～3 hour at every turn, collecting decoction filters, and filtrating is concentrated into relative density 1.00～1.35 in the time of 50～80 ℃, puts cold; 3. precipitate with ethanol: add ethanol and make and contain the alcohol amount and reach 10～85%, left standstill 3～48 hours, filter; 4. reclaim ethanol, be concentrated into relative density 1.00～1.45 in the time of 50～90 ℃, get extractum II;
C. dosing: take by weighing extractum I, add water, stir down it was boiled 2～60 minutes, make abundant dissolving, filter; In extractum II, add water and other adjuvant, stir, be heated to 30～80 ℃ and kept 2～30 minutes, filter; In an amount of polysorbate, add volatile oil, be stirred to mix homogeneously, get fragrant solution; With above-mentioned three kinds of combining medicine, add water, stir, heated and boiled 5～50 minutes, put cold, to below 80 ℃, then with medical filtration;
D. fill, gland, 90～150 ℃ of sterilizations of logical then steam 5～60 minutes promptly get oral liquid.
9. the method for preparing of the oral liquid of the pharmaceutical composition of a treatment jaundice as claimed in claim 4 comprises the steps:
A '. it is subsequent use to get 8-12 parts of Rhizoma Atractylodis, 4-8 parts of Polyporus, 3-5 parts of Herba Veronicastri caulopteris, Poria 6-12 minutes, 3-5 parts of Rhizoma Zingiberiss, 5-8 parts of Herba Rabdosiae Lophanthoidiss, 4-7 parts of Cortex Cinnamomis, 5-15 parts of the Rhizoma Atractylodis Macrocephalaes, 4-15 parts of Radix Astragali, 4-7 parts of Radix Angelicae Sinensis, 5-12 parts of Massa Medicata Fermentatas, 2-6 parts of Pericarpium Citri Reticulataes, 2-6 parts of Herba Kalimeridis;
B '. the extraction of extractum I: Rhizoma Atractylodis, Polyporus, Herba Veronicastri caulopteri add water temperature and soak secondary, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, with 6-10 times of water gaging warm macerating 1 hour, merge infusion for the second time; Poria, Rhizoma Zingiberis, Herba Rabdosiae Lophanthoidis decocting in water secondary boiled 2 hours with 10-15 times of water gaging for the first time, doubly measured with 6-12 for the second time, and decocting in water 2 hours merges water cooking liquid; Cortex Cinnamomi decocting in water secondary boiled 2 hours with 6-12 times of water gaging for the first time, boiled 2 hours with 3-8 times of water gaging for the second time; Merge above-mentioned warm macerating liquid and water cooking liquid; And the Rhizoma Atractylodis Macrocephalae is added water temperature soak secondary, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, in being filtered in 1 hour with 6-10 times of water gaging warm macerating for the second time; Merging is condensed into cream (surveying relative density 1.2-1.3 for 50 ℃), gets extractum I;
The extraction of extractum II: 1. extract volatile oil: get Radix Astragali, Radix Angelicae Sinensis, Massa Medicata Fermentata, Pericarpium Citri Reticulatae, Herba Kalimeridis five tastes medical material, merge together, add 1～12 times of water gaging; Soak after 0.5～5 hour; Adopted steam distillation 1～8 hour, and collected volatile oil device preservation in addition, medicinal residues continue to extract; 2. extract: the medicinal residues decocte with water behind extraction such as all the other medical materials and Rhizoma Atractylodis, Polyporus, Herba Veronicastri caulopteri medicinal residues and the Flos Lonicerae volatile oil 1～3 time; The each decoction 0.5～3 hour, collecting decoction filters; Filtrating is concentrated into relative density 1.00～1.35 in the time of 50～80 ℃, puts cold; 3. precipitate with ethanol: add ethanol and make and contain the alcohol amount and reach 10～85%, left standstill 3～48 hours, filter; 4. reclaim ethanol, be concentrated into relative density 1.00～1.45 in the time of 50～90 ℃, get extractum II;
C '. dosing: take by weighing extractum I, add water, stir down it was boiled 2～60 minutes, make abundant dissolving, filter; In extractum II, add water and other adjuvant, stir, be heated to 30～80 ℃ and kept 2～30 minutes, filter; In an amount of polysorbate, add volatile oil, be stirred to mix homogeneously, get fragrant solution; With above-mentioned three kinds of combining medicine, add water, stir, heated and boiled 5～50 minutes, put cold, to below 80 ℃, then with medical filtration;
D '. fill, gland, 90～150 ℃ of sterilizations of logical then steam 5～60 minutes promptly get oral liquid.
10. the method for preparing of the oral liquid of the pharmaceutical composition of a treatment jaundice as claimed in claim 6 comprises the steps:
A. it is subsequent use to get 5-12 parts of Radix Codonopsis, 8-14 parts of Radix Astragali, 6-12 parts of the Radixs Polygoni Multiflori, 5-10 parts of the Radix Paeoniae Albas, 4-8 parts of the Rhizoma Atractylodis Macrocephalaes, 8-12 parts in Poria, 4-8 parts of Radix Angelicae Sinensis, 5-10 parts in mountain Cornu Cervi Pantotrichum, 2-8 parts of Folium Artemisiae Argyis, 4-8 parts of Pericarpium Citri Reticulataes, 4-10 parts of Caulis Spatholobis, 6-12 parts of Rhizomadioscoreae;
B. the extraction of extractum I: Radix Codonopsis, Radix Astragali, the Radix Polygoni Multiflori, the Radix Paeoniae Alba add water temperature and soak secondary, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, with 6-10 times of water gaging warm macerating 1 hour, merge infusion for the second time; The Rhizoma Atractylodis Macrocephalae, Poria boil secondary, boil 2 hours with 10-15 times of water gaging for the first time, doubly measure with 6-12 for the second time, and decocting in water 2 hours merges water cooking liquid; Radix Angelicae Sinensis decocting in water secondary boiled 2 hours with 6-12 times of water gaging for the first time, boiled 2 hours with 3-8 times of water gaging for the second time; Merge above-mentioned warm macerating liquid and water cooking liquid; And the mountain Cornu Cervi Pantotrichum is added water temperature soak secondary, for the first time with 10-15 times of water gaging warm macerating 1.5 hours, in being filtered in 1 hour with 6-10 times of water gaging warm macerating for the second time; Merging is condensed into cream (surveying relative density 1.2-1.3 for 50 ℃), gets extractum I;
The extraction of extractum II: 1. extract volatile oil: get Folium Artemisiae Argyi, Pericarpium Citri Reticulatae, Caulis Spatholobi, Rhizomadioscoreae four Chinese medicine material, merge together, add 1～12 times of water gaging, soak after 0.5～5 hour, adopted steam distillation 1～8 hour, collect volatile oil device preservation in addition, medicinal residues continue to extract; 2. extract: the medicinal residues decocte with water behind extraction such as all the other medical materials and Radix Codonopsis, Radix Astragali medicinal residues and the mountain Cornu Cervi Pantotrichum volatile oil 1～3 time, decocted 0.5～3 hour at every turn, collecting decoction filters, and filtrating is concentrated into relative density 1.00～1.35 in the time of 50～80 ℃, puts cold; 3. precipitate with ethanol: add ethanol and make and contain the alcohol amount and reach 10～85%, left standstill 3～48 hours, filter; 4. reclaim ethanol, be concentrated into relative density 1.00～1.45 in the time of 50～90 ℃, get extractum II;
C. dosing: take by weighing extractum I, add water, stir down it was boiled 2～60 minutes, make abundant dissolving, filter; In extractum II, add water and other adjuvant, stir, be heated to 30～80 ℃ and kept 2～30 minutes, filter; In an amount of polysorbate, add volatile oil, be stirred to mix homogeneously, get fragrant solution; With above-mentioned three kinds of combining medicine, add water, stir, heated and boiled 5～50 minutes, put cold, to below 80 ℃, then with medical filtration;
D. fill, gland, 90～150 ℃ of sterilizations of logical then steam 5～60 minutes promptly get oral liquid.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104189579A (en) * | 2014-08-28 | 2014-12-10 | 邓鑫 | Traditional Chinese medicine composition for treating jaundice due to liver cancer |
| CN105012370A (en) * | 2015-07-03 | 2015-11-04 | 刘明璇 | Medicine for treating infant jaundice |
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| CN1853710A (en) * | 2005-04-19 | 2006-11-01 | 王文喜 | Chinese medicine for treating liver and gall diseases |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104189579A (en) * | 2014-08-28 | 2014-12-10 | 邓鑫 | Traditional Chinese medicine composition for treating jaundice due to liver cancer |
| CN104189579B (en) * | 2014-08-28 | 2017-11-21 | 邓鑫 | A kind of Chinese medicine composition for treating liver cancer jaundice |
| CN105012370A (en) * | 2015-07-03 | 2015-11-04 | 刘明璇 | Medicine for treating infant jaundice |
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