CN105168717A - Traditional Chinese medicine composition for treating haemorrhoids and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating haemorrhoids and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating haemorrhoids and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine is prepared from caulis spatholobi, indigo naturalis, hedgehog hide, periostracum cicada, cape jasmine, trametesrobiniophila, dragon's blood, bezoar, frankincense, indigofera spp, honeysuckle, radix angelicae, fructus forsythiae, ailantus endocuticle, musk, puffball, bunge corydalis herb and liquorice. The traditional Chinese medicine composition has the effects of clearing away heat and toxic materials, removing stasis and relieving pain, stopping bleeding and promoting granulation, eliminating a swelling and pus and activating blood to promote menstruation, and further has the advantages of being simple in preparation technology, good in curative effect, small in side effect, convenient to take, easy to apply and popularize and the like.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition for the treatment of hemorrhoid and preparation method thereof.
Background technology
Hemorrhoid are bottom anal orifice and rectal intestine and a kind of chronic disease of the vein group of the venous plexus generation varicose of anal mucosa and one or more softnesses of being formed.Usually continue firmly when defecation, cause intravenous pressure herein repeatedly to raise, vein will enlargement.Women is in trimester of pregnancy, and because pelvic cavity suffers oppression, hinder blood circulation often hemorrhoid can occur, the people of many obesities also can suffer from hemorrhoid.Hemorrhoid are dragged for a long time and are not controlled, and blood stasis can be caused to deviate to form incarceration, aggravate the pain and the state of an illness, secondly anal infection, once form bleeding hemorrhoids symptom, antibacterial, toxin, purulent core very easily invade blood and cause pyaemia septica etc.In addition because hemorrhoid block is deviate to cause sphincter dilatation, mucus flows out the outer long-time stimulus surrounding skin of anus, easily causes pruritus and skin eczema.
At present, the method for the treatment of hemorrhoid has operative treatment and non-operative treatment.Topical therapy in non-operative treatment is a kind of Therapeutic Method extensively adopted at present, namely the suppository containing Chinese medicine ingredients, unguentum or lotion is used to carry out drug treatment at site of pathological change, although the Therapeutic Method safety of this type and few side effects, but implement the defects such as also there is dispenser trouble and slow curative effect, although and adopt operative treatment instant effect and feature evident in efficacy, also there is treatments period affects life and work study and postoperative need such as to nurse for a long time at the defect.
Chinese patent application 201410284380.6 discloses a kind of Chinese medicine composition for the treatment of hemorrhoid, and this Chinese medicine composition is prepared from by the raw material of following parts by weight: Herba Taxilli 15-25 gram, Flos Sophorae 20-30 gram, Radix Scrophulariae 5-15 gram, Radix Glycyrrhizae 10-20 gram, Flos Chrysanthemi 10-20 gram, Herba Menthae 10-15 gram, Semen Strychni 5-10 gram, Rhizoma Coptidis 5-15 gram, Radix Scutellariae 3-8 gram, Flos Lonicerae 20-30 gram.This Chinese medicine composition has no side effect, and compares operative treatment, alleviates the pain of patient, but at heat-clearing and toxic substances removing, promoting blood circulation and detumescence aspect effect is not very remarkable.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition for the treatment of hemorrhoid, this pharmaceutical composition has heat-clearing and toxic substances removing, removing blood stasis and relieving pain, hemostasia and promoting granulation, effect of detumescence and apocenosis and promoting blood circulation to restore menstrual flow, also have that preparation technology is simple, good effect, side effect be low, taking convenience and be easy to advantages such as applying, in addition, the present invention also provides corresponding manufacturing process to be made under the prerequisite ensureing curative effect by this pharmaceutical composition to facilitate easy-to-use preparation.
The technical solution used in the present invention is:
Treat a Chinese medicine composition for hemorrhoid, be prepared from by the raw material of following parts by weight: Caulis Spatholobi 5-15 part, Indigo Naturalis 4-12 part, Corium Erinacei Seu Hemiechianus 5-12 part, Periostracum Cicadae 5-12 part, Fructus Gardeniae 1-5 part, Auricularia Sophorae 5-11 part, Sanguis Draxonis 3-7 part, Calculus Bovis 3-7 part, Olibanum 8-14 part, Rhizoma Solani tuber osi root 6-12 part, Flos Lonicerae 8-17 part, Radix Angelicae Dahuricae 5-11 part, Fructus Forsythiae 8-17 part, Cortex toonae sinensis radicis 8-17 part, Moschus 2-3 part, Lasiosphaera Seu Calvatia 5-10 part, Herba Corydalis Bungeanae 11-17 part and Radix Glycyrrhizae 3-12 part.
Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Caulis Spatholobi 5 parts, Indigo Naturalis 4 parts, Corium Erinacei Seu Hemiechianus 5 parts, Periostracum Cicadae 5 parts, Fructus Gardeniae 1 part, Auricularia Sophorae 5 parts, Sanguis Draxonis 3 parts, Calculus Bovis 3 parts, Olibanum 8 parts, Rhizoma Solani tuber osi root 6 parts, Flos Lonicerae 8 parts, the Radix Angelicae Dahuricae 5 parts, Fructus Forsythiae 8 parts, Cortex toonae sinensis radicis 8 parts, 2 parts, Moschus, Lasiosphaera Seu Calvatia 5 parts, Herba Corydalis Bungeanae 11 parts and 3 parts, Radix Glycyrrhizae.
Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Caulis Spatholobi 15 parts, Indigo Naturalis 12 parts, Corium Erinacei Seu Hemiechianus 12 parts, Periostracum Cicadae 12 parts, Fructus Gardeniae 5 parts, Auricularia Sophorae 11 parts, Sanguis Draxonis 7 parts, Calculus Bovis 7 parts, Olibanum 14 parts, Rhizoma Solani tuber osi root 12 parts, Flos Lonicerae 17 parts, the Radix Angelicae Dahuricae 11 parts, Fructus Forsythiae 17 parts, Cortex toonae sinensis radicis 17 parts, 3 parts, Moschus, Lasiosphaera Seu Calvatia 10 parts, Herba Corydalis Bungeanae 17 parts and 12 parts, Radix Glycyrrhizae.
Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Caulis Spatholobi 8 parts, Indigo Naturalis 7 parts, Corium Erinacei Seu Hemiechianus 9 parts, Periostracum Cicadae 10 parts, Fructus Gardeniae 3 parts, Auricularia Sophorae 8 parts, Sanguis Draxonis 5 parts, Calculus Bovis 4 parts, Olibanum 12 parts, Rhizoma Solani tuber osi root 8 parts, Flos Lonicerae 13 parts, the Radix Angelicae Dahuricae 9 parts, Fructus Forsythiae 16 parts, Cortex toonae sinensis radicis 14 parts, 2 parts, Moschus, Lasiosphaera Seu Calvatia 8 parts, Herba Corydalis Bungeanae 15 parts and 8 parts, Radix Glycyrrhizae.
Preferably, described Chinese medicine composition is made into capsule, granule, tablet or pill.
Accordingly, the preparation method of described Chinese medicine composition comprises following step:
(1): get Caulis Spatholobi, wash away impurity, crushed after being dried, cross 80-100 mesh sieve, adding Caulis Spatholobi coarse powder gross weight 8-10 times amount volume fraction is the ethanol of 60-80%, add the cellulase of Caulis Spatholobi coarse powder total amount 0.8%-1.2% again, lixiviate 1-2 hour at 38-45 DEG C, then at 85-95 DEG C of reflux, extract, 1-2 hour, filters and retains Caulis Spatholobi filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtains Caulis Spatholobi extract;
(2): get Indigo Naturalis, Corium Erinacei Seu Hemiechianus, Periostracum Cicadae, Fructus Gardeniae, Auricularia Sophorae, Sanguis Draxonis, Calculus Bovis, Olibanum, Rhizoma Solani tuber osi root, Flos Lonicerae, the Radix Angelicae Dahuricae, Fructus Forsythiae, Cortex toonae sinensis radicis, Moschus moschiferous is fragrant, Lasiosphaera Seu Calvatia, Herba Corydalis Bungeanae and Radix Glycyrrhizae, wash away impurity, crushed after being dried, the Caulis Spatholobi medicinal residues obtained with step (1) mix, add the water of above-mentioned coarse powder total amount 15-20 times amount, soak 20-30 minute, reflux, extract, 2-3 time, each 1-3 hour, filter, merging filtrate, concentrate filtrate at 60 DEG C and survey the extractum that relative density is 1.10-1.20, cooling, slowly add ethanol while stirring to alcohol content for reaching 40-60%, 4 DEG C of standing 12-24 hour, filter and retain filtering residue, obtain filtrate A,
(3): it is the ethanol of 40-60% that filtering residue step (2) obtained slowly adds filtering residue weight 4-6 times amount volume fraction while stirring, 4 DEG C of standing 3-5 hour, filter, obtain liquor B and filtering residue; Filtering residue uses the washing with alcohol 2-3 time of 40-60% again, collects and merges cleaning mixture;
(4): step (2) is obtained filtrate A and obtain liquor B with step (3) and cleaning mixture mixes, under being evaporated to 60 DEG C of conditions after mixing, survey the extractum that relative density is 1.20-1.25;
(5): the extractum that Caulis Spatholobi extract step (1) obtained and step (4) obtain is mixed homogeneously, and carries out spraying dry, inlet temperature 80-120 DEG C, outlet temperature 45-80 DEG C, wind speed 5-10m/s, pressure 0.02-0.1kPa; Dried powder is crossed 100-200 mesh sieve, to obtain final product.
Source, the nature and flavor of the present invention's component used, return through and effect:
Caulis Spatholobi: this product is the plant of pulse family Millettia, bitter in the mouth, sweet, warm in nature; Return liver, kidney channel; Enrich blood, invigorate blood circulation, dredging collateral; Relaxing muscles and tendons to promote blood circulation, nourishing blood for regulating menstruation.
Indigo Naturalis: for the leaf of rank of nobility dinner party section plant Acanthaceous indigo, polygonaceae plant polygonum tinctorium ait., cruciferae isatis or stem and leaf are through processing obtained dried powder, agglomerate or granule, salty in the mouth, cold in nature; Return Liver Channel; Tool heat-clearing and toxic substances removing, removing heat from blood are loose swollen, the effect of pathogenic fire purging arresting convulsion.
Corium Erinacei Seu Hemiechianus: this product is the dry crust of Erinaceidae animal Rrinaceus earopaeus; Bitter in the mouth, sweet, property is put down; Return stomach, large intestine, kidney channel; Clots absorbing pain relieving, hemostasis, controlling nocturnal emission with astringent drugs.
Periostracum Cicadae: exuviae shell when this product is the larva emergence of cicada Cryptotympana atrata Fabr.; Sweet in the mouth, cold in nature; Return lung, Liver Channel; Loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.
Fructus Gardeniae: this product is the fruit of Maguireothamnus speciosus Fructus Gardeniae; Bitter in the mouth, cold in nature; GUIXIN, lung, tri-jiao channel; Clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, reducing swelling and alleviating pain.
Auricularia Sophorae: this product is the Auricularia parasitized on Sophora japonica L.; Bitter in the mouth, pungent, property is put down; Return liver, spleen, large intestine channel; Hemostasis; Dysentery relieving; Anticancer.
Sanguis Draxonis: this product is that the resin that oozes out of babassu Sanguis Draxonis fruit is through being processed into; Sweet in the mouth, salty, property is put down; GUIXIN, Liver Channel; Removing blood stasis and relieving pain, hemostasia and promoting granulation.
Calculus Bovis: this product is the cholelithiasis of Chordata Mammalia bovid cattle drying; Mildly bitter flavor is then sweet, cool in nature; Antipyretic, removing toxic substances.
Olibanum: this product is that the oleo-gum-resin that Burseraceae Boswellia carterii platymiscium Boswellia carterii is oozed out with its trunk skin zone wound is used as medicine; Acrid in the mouth, hardship, warm in nature; Enter the heart, liver, spleen channel; Promoting blood circulation and stopping pain.
Rhizoma Solani tuber osi root: the root and rhizome of leguminous plant indigofera fortunei Craib, pink indigo, Yichang Folium et Caulis Indigoferae Tinctoriae, Radix Indigoferae Carlesii, Shaanxi Folium et Caulis Indigoferae Tinctoriae, HUAMU indigo plant; Bitter in the mouth, has heat-clearing and toxic substances removing, loose swollen pain relieving.
Flos Lonicerae: this product is dry flower or the first flower opened of band of caprifoliaceae plant Radix Ophiopogonis; Sweet in the mouth, cold in nature; Return lung, the heart, stomach warp; Heat-clearing and toxic substances removing, wind-heat dissipating.
The Radix Angelicae Dahuricae: this product is the dry root of the umbellate form section plant Radix Angelicae Dahuricae; Acrid in the mouth, warm in nature; Return stomach, large intestine, lung meridian; Loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.
Fructus Forsythiae: this product is the dry fruit of Oleaceae plants Fructus Forsythiae; Bitter in the mouth, cold nature; Return lung, the heart, small intestine meridian; Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.
Cortex toonae sinensis radicis: this product is the phloem of Meliaceae plant bark of Toona sinensis or root bark; Bitter and puckery flavor, cool in nature; Return large intestine, stomach warp; Heat clearing and damp drying, astringing intestine to stop diarrhea, hemostasis.
Moschus: this product is the dry secretions in the ripe male body note capsule of animal in deer family woods Moschus moschiferous, horse Moschus moschiferous or former Moschus moschiferous; Acrid in the mouth, warm in nature; GUIXIN, spleen channel; To have one's ideas straightened out refreshment, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain.
Lasiosphaera Seu Calvatia: this product belongs to basidiomycetes Lycoperdaceae; Acrid in the mouth, property is put down; Lung heat clearing, removing toxic substances, hemostasis.
Herba Corydalis Bungeanae: this product is the herb of Papaveraceae Genus Corydalis Herba Corydalis Bungeanae; Bitter in the mouth, cold in nature; GUIXIN, spleen channel; Heat-clearing and toxic substances removing, promoting blood circulation and detumescence.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Compared with prior art, the present invention has following technical advantage:
1, Chinese medicine composition of the present invention is compared with the medicine of other treatment hemorrhoid, and at heat-clearing and toxic substances removing, removing blood stasis and relieving pain, the aspects such as hemostasia and promoting granulation, detumescence and apocenosis and promoting blood circulation to restore menstrual flow have more remarkable efficacy.
2, compared with the chemotherapeutic agent of Current therapeutic hemorrhoid, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, untoward reaction and side effect significantly reduce, and Chinese medicine composition effect of the present invention is comprehensive, medication effect is better, efficiently solve the morbidity root of hemorrhoid, and improve the quality of life of patient.
3, Chinese medicine composition of the present invention also has that compatibility science, preparation technology are simple, good effect, side effect are low, taking convenience and be easy to advantages such as applying.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.
embodiment 1:
By following weight portion weighting raw materials: Caulis Spatholobi 5 parts, Indigo Naturalis 4 parts, Corium Erinacei Seu Hemiechianus 5 parts, Periostracum Cicadae 5 parts, Fructus Gardeniae 1 part, Auricularia Sophorae 5 parts, Sanguis Draxonis 3 parts, Calculus Bovis 3 parts, Olibanum 8 parts, Rhizoma Solani tuber osi root 6 parts, Flos Lonicerae 8 parts, the Radix Angelicae Dahuricae 5 parts, Fructus Forsythiae 8 parts, Cortex toonae sinensis radicis 8 parts, 2 parts, Moschus, Lasiosphaera Seu Calvatia 5 parts, Herba Corydalis Bungeanae 11 parts and 3 parts, Radix Glycyrrhizae.
Preparation method is as follows:
(1): get Caulis Spatholobi, wash away impurity, crushed after being dried, cross 80 mesh sieves, adding Caulis Spatholobi coarse powder gross weight 8 times amount volume fraction is the ethanol of 60%, add the cellulase of Caulis Spatholobi coarse powder total amount 0.8% again, lixiviate 1 hour at 38 DEG C, then 85 DEG C of reflux, extract, 1 hour, filters and retains Caulis Spatholobi filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10, obtains Caulis Spatholobi extract;
(2): get Indigo Naturalis, Corium Erinacei Seu Hemiechianus, Periostracum Cicadae, Fructus Gardeniae, Auricularia Sophorae, Sanguis Draxonis, Calculus Bovis, Olibanum, Rhizoma Solani tuber osi root, Flos Lonicerae, the Radix Angelicae Dahuricae, Fructus Forsythiae, Cortex toonae sinensis radicis, Moschus moschiferous is fragrant, Lasiosphaera Seu Calvatia, Herba Corydalis Bungeanae and Radix Glycyrrhizae, wash away impurity, crushed after being dried, the Caulis Spatholobi medicinal residues obtained with step (1) mix, add the water of above-mentioned coarse powder total amount 15 times amount, soak 20 minutes, reflux, extract, 2 times, each 1 hour, filter, merging filtrate, the extractum that relative density is 1.10 is surveyed at filtrate reduced in volume to 60 DEG C, cooling, slowly add ethanol while stirring to alcohol content for reaching 40%, 4 DEG C leave standstill 12 hours, filter and retain filtering residue, obtain filtrate A,
(3): it is the ethanol of 40% that filtering residue step (2) obtained slowly adds filtering residue weight 4 times amount volume fraction while stirring, 4 DEG C leave standstill 3 hours, filter, obtain liquor B and filtering residue; Filtering residue uses the washing with alcohol 2 times of 40% again, collects and merges cleaning mixture;
(4): the liquor B that filtrate A step (2) obtained and step (3) obtain and cleaning mixture mix, and survey extractum that relative density be 1.20 under being evaporated to 60 DEG C of conditions after mixing;
(5): the extractum that Caulis Spatholobi extract step (1) obtained and step (4) obtain mixes, and carries out spraying dry, inlet temperature 80 DEG C, outlet temperature 45 DEG C, wind speed 5m/s, pressure 0.02kPa; Dried powder is crossed 100 mesh sieves, adds corresponding adjuvant, make capsule.
embodiment 2:
By following weight portion weighting raw materials: Caulis Spatholobi 15 parts, Indigo Naturalis 12 parts, Corium Erinacei Seu Hemiechianus 12 parts, Periostracum Cicadae 12 parts, Fructus Gardeniae 5 parts, Auricularia Sophorae 11 parts, Sanguis Draxonis 7 parts, Calculus Bovis 7 parts, Olibanum 14 parts, Rhizoma Solani tuber osi root 12 parts, Flos Lonicerae 17 parts, the Radix Angelicae Dahuricae 11 parts, Fructus Forsythiae 17 parts, Cortex toonae sinensis radicis 17 parts, 3 parts, Moschus, Lasiosphaera Seu Calvatia 10 parts, Herba Corydalis Bungeanae 17 parts and 12 parts, Radix Glycyrrhizae.
Preparation method is as follows:
(1): get Caulis Spatholobi, wash away impurity, crushed after being dried, cross 100 mesh sieves, adding Caulis Spatholobi coarse powder gross weight 9 times amount volume fraction is the ethanol of 70%, add the cellulase of Caulis Spatholobi coarse powder total amount 0.9% again, lixiviate 2 hours at 43 DEG C, then 90 DEG C of reflux, extract, 2 hours, filters and retains Caulis Spatholobi filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.20, obtained Caulis Spatholobi extract;
(2): get Indigo Naturalis, Corium Erinacei Seu Hemiechianus, Periostracum Cicadae, Fructus Gardeniae, Auricularia Sophorae, Sanguis Draxonis, Calculus Bovis, Olibanum, Rhizoma Solani tuber osi root, Flos Lonicerae, the Radix Angelicae Dahuricae, Fructus Forsythiae, Cortex toonae sinensis radicis, Moschus moschiferous is fragrant, Lasiosphaera Seu Calvatia, Herba Corydalis Bungeanae and Radix Glycyrrhizae, wash away impurity, crushed after being dried, the Caulis Spatholobi medicinal residues obtained with step (1) mix, add the water of above-mentioned coarse powder total amount 18 times amount, soak 25 minutes, reflux, extract, 2 times, each 2 hours, filter, merging filtrate, the extractum that relative density is 1.15 is surveyed at filtrate reduced in volume to 60 DEG C, cooling, slowly add ethanol while stirring to alcohol content for reaching 50%, 4 DEG C leave standstill 18 hours, filter and retain filtering residue, obtain filtrate A,
(3): it is the ethanol of 50% that filtering residue step (2) obtained slowly adds filtering residue weight 5 times amount volume fraction while stirring, 4 DEG C leave standstill 4 hours, filter, obtain liquor B and filtering residue; Filtering residue uses the washing with alcohol 2 times of 50% again, collects and merges cleaning mixture;
(4): the liquor B that filtrate A step (2) obtained and step (3) obtain and cleaning mixture mix, and survey extractum that relative density be 1.22 under being evaporated to 60 DEG C of conditions after mixing;
(5): the extractum that Caulis Spatholobi extract step (1) obtained and step (4) obtain mixes, and carries out spraying dry, inlet temperature 100 DEG C, outlet temperature 60 DEG C, wind speed 8m/s, pressure 0.08kPa; Dried powder is crossed 120 mesh sieves, adds corresponding adjuvant, make granule.
embodiment 3:
By following weight portion weighting raw materials: Caulis Spatholobi 8 parts, Indigo Naturalis 7 parts, Corium Erinacei Seu Hemiechianus 9 parts, Periostracum Cicadae 10 parts, Fructus Gardeniae 3 parts, Auricularia Sophorae 8 parts, Sanguis Draxonis 5 parts, Calculus Bovis 4 parts, Olibanum 12 parts, Rhizoma Solani tuber osi root 8 parts, Flos Lonicerae 13 parts, the Radix Angelicae Dahuricae 9 parts, Fructus Forsythiae 16 parts, Cortex toonae sinensis radicis 14 parts, 2 parts, Moschus, Lasiosphaera Seu Calvatia 8 parts, Herba Corydalis Bungeanae 15 parts and 8 parts, Radix Glycyrrhizae.
Preparation method is as follows:
(1): get Caulis Spatholobi, wash away impurity, crushed after being dried, cross 100 mesh sieves, adding Caulis Spatholobi coarse powder gross weight 10 times amount volume fraction is the ethanol of 80%, add the cellulase of Caulis Spatholobi coarse powder total amount 1.2% again, lixiviate 2 hours at 45 DEG C, then 95 DEG C of reflux, extract, 2 hours, filters and retains Caulis Spatholobi filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.25, obtains Caulis Spatholobi extract;
(2): get Indigo Naturalis, Corium Erinacei Seu Hemiechianus, Periostracum Cicadae, Fructus Gardeniae, Auricularia Sophorae, Sanguis Draxonis, Calculus Bovis, Olibanum, Rhizoma Solani tuber osi root, Flos Lonicerae, the Radix Angelicae Dahuricae, Fructus Forsythiae, Cortex toonae sinensis radicis, Moschus moschiferous is fragrant, Lasiosphaera Seu Calvatia, Herba Corydalis Bungeanae and Radix Glycyrrhizae, wash away impurity, crushed after being dried, the Caulis Spatholobi medicinal residues obtained with step (1) mix, add the water of above-mentioned coarse powder total amount 20 times amount, soak 30 minutes, reflux, extract, 3 times, each 3 hours, filter, merging filtrate, the extractum that relative density is 1.20 is surveyed at filtrate reduced in volume to 60 DEG C, cooling, slowly add ethanol while stirring to alcohol content for reaching 60%, 4 DEG C leave standstill 24 hours, filter and retain filtering residue, obtain filtrate A,
(3): it is the ethanol of 60% that filtering residue step (2) obtained slowly adds filtering residue weight 6 times amount volume fraction while stirring, 4 DEG C leave standstill 5 hours, filter, obtain liquor B and filtering residue; Filtering residue uses the washing with alcohol 3 times of 60% again, collects and merges cleaning mixture;
(4): the liquor B that filtrate A step (2) obtained and step (3) obtain and cleaning mixture mix, and survey extractum that relative density be 1.25 under being evaporated to 60 DEG C of conditions after mixing;
(5): the extractum that Caulis Spatholobi extract step (1) obtained and step (4) obtain mixes, and carries out spraying dry, inlet temperature 120 DEG C, outlet temperature 80 DEG C, wind speed 10m/s, pressure 0.1kPa; Dried powder is crossed 200 mesh sieves, adds corresponding adjuvant, make pill.
clinical observation on the therapeutic effect
1, case selection: in 120 routine hemorrhoid clinical volunteers patients, male patient 70 example, female patient 50 example, age bracket is 18-65 year, 40 years old mean age, all patients all has typical hemorrhoid symptom, and in sex, age, the course of disease no difference of science of statistics.
2, diagnostic criteria:
(1) tcm diagnosis standard: " the Chinese medical disease Standardization of diagnosis and curative effect " issued according to State Administration of Traditional Chinese Medicine: have anal abscess medical history; Focus has collar extension, pipeline, internal orifice to levy.
(2) Western medicine diagnose standard: 1. intermittence just time podex hemorrhage, showing as stool band blood, dye paper, bleed or penetrate blood;
2., after stool or fatigue, cystic mass is had to deviate from outside anus, can self-resetting or need manual reduction maybe can not reset; 3. podex has foreign body sensation, does not accommodate pain with falling inflation; 4. show color cystic mass on tooth trace, is common in right front, right back, left side, and surface mucous is congested, rotten to the corn or have fibrosis lesion; 5. anal canal and anus edge place mulberry cystic mass, or happen suddenly ecchymosis or thrombosis.
3, exclusion standard: 1. other diseases, syndrome or complication; 2. associated treatment has been accepted and possibility influential effect observation index; 3. with the observation of energy influential effect index, other physiology judged or pathological condition; 4. severe cardiac, liver, kidney, hematological affect drug metabolism; 5. characterizing population group's (edge design women, psychosis).Before including in, accept Drug therapy, meet inclusive criteria through eluting after date, be not considered as Excluded cases.
4, standard is exited: 1. not by the measure of regulation Intervention, curative effect cannot be judged.2. data does not judge curative effect, safety completely without method.3. serious adverse reaction, complication, special physiological change etc., are difficult to continual cure.(untoward reaction person includes bad reflection statistics in).4. the medicine that affects the treatment is used.Exit/come off case and include efficacy determination in by curative effect when exiting/come off.
5, efficacy assessment standard:
Cure: patient does not occur deviating from or the symptom such as to have blood in stool, nevus core atrophy or disappear completely;
Effective: patient does not occur deviating from or the symptom such as to have blood in stool, and nevus core obviously reduces;
Invalid: symptom is not improved;
Total effective rate=(cure+effectively)/total number of cases × 100%.
6, instructions of taking: 120 patients are divided into 2 groups at random, often organize 60 people, be respectively treatment group and matched group, treatment group takes the pill that the embodiment of the present invention 3 prepares, each 3g, every day 3 times, serve on two weeks.Matched group takes SANQI HUAZHI WAN (Guangzhou Baiyunshan Zhongyi Pharmaceutical Co., Ltd., the accurate word 02Z12442 of traditional Chinese medicines), and each 3g, 2-3 time on the one, serve on two weeks.
7, therapeutic outcome: as shown in table 1.
Table 1 therapeutic outcome
This test adopts SANQI HUAZHI WAN as a control group, compares, can find out the curative effect of traditional Chinese medicine composition for treating hemorrhoid of the present invention with the therapeutic effect of Chinese medicine composition of the present invention.Make inventor surprisingly, the cure rate of Chinese medicine composition of the present invention reaches 85%, total effective rate more than 90.0%, far above cure rate and the total effective rate of matched group, visible, particularly the curative effect of medicine for preparing of embodiment 3 is good for Chinese medicine composition of the present invention, and cure rate is high, can be used as the drug use for the treatment of hemorrhoid.
Owing to describing the present invention by above preferred embodiment, in spirit of the present invention and/or scope, any for replacement/of the present invention or combination implement the present invention, be all apparent for a person skilled in the art, and be included among the present invention.
Claims (6)
1. treat the Chinese medicine composition of hemorrhoid for one kind; it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Caulis Spatholobi 5-15 part, Indigo Naturalis 4-12 part, Corium Erinacei Seu Hemiechianus 5-12 part, Periostracum Cicadae 5-12 part, Fructus Gardeniae 1-5 part, Auricularia Sophorae 5-11 part, Sanguis Draxonis 3-7 part, Calculus Bovis 3-7 part, Olibanum 8-14 part, Rhizoma Solani tuber osi root 6-12 part, Flos Lonicerae 8-17 part, Radix Angelicae Dahuricae 5-11 part, Fructus Forsythiae 8-17 part, Cortex toonae sinensis radicis 8-17 part, Moschus 2-3 part, Lasiosphaera Seu Calvatia 5-10 part, Herba Corydalis Bungeanae 11-17 part and Radix Glycyrrhizae 3-12 part.
2. the Chinese medicine composition for the treatment of hemorrhoid as claimed in claim 1; it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Caulis Spatholobi 5 parts, Indigo Naturalis 4 parts, Corium Erinacei Seu Hemiechianus 5 parts, Periostracum Cicadae 5 parts, Fructus Gardeniae 1 part, Auricularia Sophorae 5 parts, Sanguis Draxonis 3 parts, Calculus Bovis 3 parts, Olibanum 8 parts, Rhizoma Solani tuber osi root 6 parts, Flos Lonicerae 8 parts, the Radix Angelicae Dahuricae 5 parts, Fructus Forsythiae 8 parts, Cortex toonae sinensis radicis 8 parts, 2 parts, Moschus, Lasiosphaera Seu Calvatia 5 parts, Herba Corydalis Bungeanae 11 parts and 3 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition for the treatment of hemorrhoid as claimed in claim 1; it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Caulis Spatholobi 15 parts, Indigo Naturalis 12 parts, Corium Erinacei Seu Hemiechianus 12 parts, Periostracum Cicadae 12 parts, Fructus Gardeniae 5 parts, Auricularia Sophorae 11 parts, Sanguis Draxonis 7 parts, Calculus Bovis 7 parts, Olibanum 14 parts, Rhizoma Solani tuber osi root 12 parts, Flos Lonicerae 17 parts, the Radix Angelicae Dahuricae 11 parts, Fructus Forsythiae 17 parts, Cortex toonae sinensis radicis 17 parts, 3 parts, Moschus, Lasiosphaera Seu Calvatia 10 parts, Herba Corydalis Bungeanae 17 parts and 12 parts, Radix Glycyrrhizae.
4. the Chinese medicine composition for the treatment of hemorrhoid as claimed in claim 1; it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Caulis Spatholobi 8 parts, Indigo Naturalis 7 parts, Corium Erinacei Seu Hemiechianus 9 parts, Periostracum Cicadae 10 parts, Fructus Gardeniae 3 parts, Auricularia Sophorae 8 parts, Sanguis Draxonis 5 parts, Calculus Bovis 4 parts, Olibanum 12 parts, Rhizoma Solani tuber osi root 8 parts, Flos Lonicerae 13 parts, the Radix Angelicae Dahuricae 9 parts, Fructus Forsythiae 16 parts, Cortex toonae sinensis radicis 14 parts, 2 parts, Moschus, Lasiosphaera Seu Calvatia 8 parts, Herba Corydalis Bungeanae 15 parts and 8 parts, Radix Glycyrrhizae.
5. the Chinese medicine composition of the treatment hemorrhoid as described in any one of claim 1-4, is characterized in that: described Chinese medicine composition is made into capsule, granule, tablet or pill.
6. a preparation method for the Chinese medicine composition of the treatment hemorrhoid as described in any one of claim 1-4, is characterized in that, the preparation method of described Chinese medicine composition comprises following step:
(1): get Caulis Spatholobi, wash away impurity, crushed after being dried, cross 80-100 mesh sieve, adding Caulis Spatholobi coarse powder gross weight 8-10 times amount volume fraction is the ethanol of 60-80%, add the cellulase of Caulis Spatholobi coarse powder total amount 0.8%-1.2% again, lixiviate 1-2 hour at 38-45 DEG C, then at 85-95 DEG C of reflux, extract, 1-2 hour, filters and retains Caulis Spatholobi filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtains Caulis Spatholobi extract;
(2): get Indigo Naturalis, Corium Erinacei Seu Hemiechianus, Periostracum Cicadae, Fructus Gardeniae, Auricularia Sophorae, Sanguis Draxonis, Calculus Bovis, Olibanum, Rhizoma Solani tuber osi root, Flos Lonicerae, the Radix Angelicae Dahuricae, Fructus Forsythiae, Cortex toonae sinensis radicis, Moschus moschiferous is fragrant, Lasiosphaera Seu Calvatia, Herba Corydalis Bungeanae and Radix Glycyrrhizae, wash away impurity, crushed after being dried, the Caulis Spatholobi medicinal residues obtained with step (1) mix, add the water of above-mentioned coarse powder total amount 15-20 times amount, soak 20-30 minute, reflux, extract, 2-3 time, each 1-3 hour, filter, merging filtrate, concentrate filtrate at 60 DEG C and survey the extractum that relative density is 1.10-1.20, cooling, slowly add ethanol while stirring to alcohol content for reaching 40-60%, 4 DEG C of standing 12-24 hour, filter and retain filtering residue, obtain filtrate A,
(3): it is the ethanol of 40-60% that filtering residue step (2) obtained slowly adds filtering residue weight 4-6 times amount volume fraction while stirring, 4 DEG C of standing 3-5 hour, filter, obtain liquor B and filtering residue; Filtering residue uses the washing with alcohol 2-3 time of 40-60% again, collects and merges cleaning mixture;
(4): step (2) is obtained filtrate A and obtain liquor B with step (3) and cleaning mixture mixes, under being evaporated to 60 DEG C of conditions after mixing, survey the extractum that relative density is 1.20-1.25;
(5): the extractum that Caulis Spatholobi extract step (1) obtained and step (4) obtain is mixed homogeneously, and carries out spraying dry, inlet temperature 80-120 DEG C, outlet temperature 45-80 DEG C, wind speed 5-10m/s, pressure 0.02-0.1kPa; Dried powder is crossed 100-200 mesh sieve, to obtain final product.
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CN105920169A (en) * | 2016-06-22 | 2016-09-07 | 朱明浩 | Traditional Chinese medicine composition for treating haemorrhoids, external preparation, and preparation method and application thereof |
CN106362044A (en) * | 2016-09-29 | 2017-02-01 | 武汉安孕堂生物科技有限公司 | Chinese medicine gel used for treating hemorrhoids of pregnant women |
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CN1554377A (en) * | 2003-12-22 | 2004-12-15 | 阎怀玉 | Chinese herbal medicine for treating piles |
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