CN105832972A - Method for preparing traditional Chinese medicine composition for treating haemorrhoids - Google Patents
Method for preparing traditional Chinese medicine composition for treating haemorrhoids Download PDFInfo
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- CN105832972A CN105832972A CN201610322700.1A CN201610322700A CN105832972A CN 105832972 A CN105832972 A CN 105832972A CN 201610322700 A CN201610322700 A CN 201610322700A CN 105832972 A CN105832972 A CN 105832972A
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Abstract
The invention discloses a method for preparing a traditional Chinese medicine composition for treating haemorrhoids, and belongs to the technical field of traditional Chinese medicines. The method includes the step that suberect spatholobus stemd, indigo naturalis, hedgehog hide, periostracum cicada, cape jasmine fruits, trametes robiniphila murr, sangusis draconis, calculus bovis, frankincense, potato roots, lonicera japonica, angelica roots, fructus forsythiae, ailantus endocuticle, musk, puffballs, bunge corydalis herbs and liquorice roots serve as raw materials to prepare the traditional Chinese medicine composition. The traditional Chinese medicine composition prepared with the method has the effects of clearing heat, removing toxicity, removing blood stasis, reducing pain, stopping blood, promoting tissue regeneration, diminishing swelling, evacuating pus, activating blood and promoting menstruation, and further has the advantages of being simple in preparing technology, good in treatment effect, low in side effect, convenient to take, easy to apply and popularize and the like.
Description
The application is that the application for a patent for invention that applicant Linyi Cao Zhimei Pharmaceutical Technology Co., Ltd proposes is (invention entitled: a kind of Chinese medicine composition treating hemorrhoid and preparation method thereof, Application No.: 2015106516102, filing date: on October 10th, 2015) divisional application.
Technical field
The invention belongs to technical field of Chinese medicines, a kind of method particularly relating to Chinese medicine composition preparing treatment hemorrhoid.
Background technology
Hemorrhoid are bottom anal orifice and rectal intestine and a kind of chronic disease of the vein group of the venous plexus generation varicose of anal mucosa and one or more softnesses of being formed.Generally persistently exerting oneself when defecation, cause intravenous pressure herein repeatedly to raise, vein will enlargement.Women is in trimester of pregnancy, owing to pelvic cavity suffers oppression, hinders blood circulation that hemorrhoid, many fat people often can be occurred also to suffer from hemorrhoid.Hemorrhoid are dragged for a long time and are not controlled, and blood stasis abjection can be caused to form incarceration, aggravate the pain and the state of an illness, secondly anal infection, once form bleeding hemorrhoids symptom, and antibacterial, toxin, purulent core easily invade blood and cause pyaemia septica etc..Additionally due to the abjection of hemorrhoid block causes sphincter dilatation, mucus flows out the outer long-time stimulus surrounding skin of anus, is easily caused pruritus and skin eczema.
At present, the method for the treatment of hemorrhoid has operative treatment and non-operative treatment.Topical therapy in non-operative treatment is the most widely used a kind of Therapeutic Method, i.e. it is administered treatment to using at site of pathological change containing the suppository of Chinese medicine ingredients, unguentum or lotion, although the Therapeutic Method safety of this type and few side effects, but implement the defects such as also there is dispenser trouble and slow curative effect, although and use operative treatment instant effect and feature evident in efficacy, but affecting the defects such as life and work study and the nursing for a long time of postoperative need during there is also treatment.
Chinese patent application 201410284380.6 discloses a kind of Chinese medicine composition treating hemorrhoid, and this Chinese medicine composition is prepared from by the raw material of following parts by weight: Herba Taxilli 15-25 gram, 20-30 gram of Flos Sophorae, Radix Scrophulariae 5-15 gram, 10-20 gram of Radix Glycyrrhizae, Flos Chrysanthemi 10-20 gram, Herba Menthae 10-15 gram, Semen Strychni 5-10 gram, Rhizoma Coptidis 5-15 gram, Radix Scutellariae 3-8 gram, Flos Lonicerae 20-30 gram.This Chinese medicine composition has no side effect, and compares operative treatment, alleviates the pain of patient, but at heat-clearing and toxic substances removing, promoting blood circulation and detumescence aspect effect is not the most notable.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of method of Chinese medicine composition preparing treatment hemorrhoid, Chinese medicine composition prepared by the method has heat-clearing and toxic substances removing, removing blood stasis and relieving pain, hemostasia and promoting granulation, detumescence and apocenosis and effect of promoting blood circulation to restore menstrual flow, also have that preparation technology is simple, an advantage such as good effect, side effect are low, taking convenience and application easy to spread.
The technical solution used in the present invention is:
A kind of Chinese medicine composition treating hemorrhoid, is prepared from by the raw material of following parts by weight: Caulis Spatholobi 5-15 part, Indigo Naturalis 4-12 part, Corium Erinacei Seu Hemiechianus 5-12 part, Periostracum Cicadae 5-12 part, Fructus Gardeniae 1-5 part, Auricularia Sophorae 5-11 part, Sanguis Draxonis 3-7 part, Calculus Bovis 3-7 part, Olibanum 8-14 part, Rhizoma Solani tuber osi root 6-12 part, Flos Lonicerae 8-17 part, Radix Angelicae Dahuricae 5-11 part, Fructus Forsythiae 8-17 part, Cortex toonae sinensis radicis 8-17 part, Moschus 2-3 part, Lasiosphaera Seu Calvatia 5-10 part, Herba Corydalis Bungeanae 11-17 part and Radix Glycyrrhizae 3-12 part.
Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Caulis Spatholobi 5 parts, Indigo Naturalis 4 parts, Corium Erinacei Seu Hemiechianus 5 parts, Periostracum Cicadae 5 parts, Fructus Gardeniae 1 part, Auricularia Sophorae 5 parts, Sanguis Draxonis 3 parts, Calculus Bovis 3 parts, Olibanum 8 parts, Rhizoma Solani tuber osi root 6 parts, Flos Lonicerae 8 parts, the Radix Angelicae Dahuricae 5 parts, Fructus Forsythiae 8 parts, Cortex toonae sinensis radicis 8 parts, 2 parts of Moschus, Lasiosphaera Seu Calvatia 5 parts, Herba Corydalis Bungeanae 11 parts and 3 parts of Radix Glycyrrhizae.
Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Caulis Spatholobi 15 parts, Indigo Naturalis 12 parts, Corium Erinacei Seu Hemiechianus 12 parts, Periostracum Cicadae 12 parts, Fructus Gardeniae 5 parts, Auricularia Sophorae 11 parts, Sanguis Draxonis 7 parts, Calculus Bovis 7 parts, Olibanum 14 parts, Rhizoma Solani tuber osi root 12 parts, Flos Lonicerae 17 parts, the Radix Angelicae Dahuricae 11 parts, Fructus Forsythiae 17 parts, Cortex toonae sinensis radicis 17 parts, 3 parts of Moschus, Lasiosphaera Seu Calvatia 10 parts, Herba Corydalis Bungeanae 17 parts and 12 parts of Radix Glycyrrhizae.
Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Caulis Spatholobi 8 parts, Indigo Naturalis 7 parts, Corium Erinacei Seu Hemiechianus 9 parts, Periostracum Cicadae 10 parts, Fructus Gardeniae 3 parts, Auricularia Sophorae 8 parts, Sanguis Draxonis 5 parts, Calculus Bovis 4 parts, Olibanum 12 parts, Rhizoma Solani tuber osi root 8 parts, Flos Lonicerae 13 parts, the Radix Angelicae Dahuricae 9 parts, Fructus Forsythiae 16 parts, Cortex toonae sinensis radicis 14 parts, 2 parts of Moschus, Lasiosphaera Seu Calvatia 8 parts, Herba Corydalis Bungeanae 15 parts and 8 parts of Radix Glycyrrhizae.
Preferably, described Chinese medicine composition is made into capsule, granule, tablet or pill.
The present invention prepares the method for Chinese medicine composition for the treatment of hemorrhoid and comprises following step:
(1): weigh weight portion Caulis Spatholobi 5-15 part, wash away impurity, crushed after being dried, crosses 80-100 mesh sieve, and adding Caulis Spatholobi coarse powder gross weight 8-10 times amount volume fraction is the ethanol of 60-80%, add the cellulase of Caulis Spatholobi coarse powder total amount 0.8%-1.2%, extract 1-2 hour at 38-45 DEG C, then 85-95 DEG C of reflux, extract, 1-2 hour, filter and retain Caulis Spatholobi filtering residue, filtrate reduced in volume is the extractum of 1.10-1.25 to relative density at 60 DEG C, obtains Caulis Spatholobi extract；
null(2): weigh weight portion Indigo Naturalis 4-12 part、Corium Erinacei Seu Hemiechianus 5-12 part、Periostracum Cicadae 5-12 part、Fructus Gardeniae 1-5 part、Auricularia Sophorae 5-11 part、Sanguis Draxonis 3-7 part、Calculus Bovis 3-7 part、Olibanum 8-14 part、Rhizoma Solani tuber osi root 6-12 part、Flos Lonicerae 8-17 part、Radix Angelicae Dahuricae 5-11 part、Fructus Forsythiae 8-17 part、Cortex toonae sinensis radicis 8-17 part、Moschus 2-3 part、Lasiosphaera Seu Calvatia 5-10 part、Herba Corydalis Bungeanae 11-17 part and Radix Glycyrrhizae 3-12 part，Wash away impurity，Crushed after being dried，The Caulis Spatholobi medicinal residues obtained with step (1) mix，Add the water of above-mentioned coarse powder total amount 15-20 times amount，Soak 20-30 minute，Reflux, extract, 2-3 time，1-3 hour every time，Filter，Merging filtrate，Concentrating filtrate to survey relative density at 60 DEG C is the extractum of 1.10-1.20，Cooling，It is slowly added to ethanol while stirring to alcohol content for reaching 40-60%，4 DEG C stand 12-24 hour，Filter and retain filtering residue，Obtain filtrate A；
(3): it is the ethanol of 40-60% that the filtering residue that step (2) obtains is slowly added to filtering residue weight 4-6 times amount volume fraction while stirring, 4 DEG C stand 3-5 hour, filter, obtain liquor B and filtering residue；Filtering residue by washing with alcohol 2-3 time of 40-60%, is collected and merges cleaning mixture again；
(4): step (2) obtains filtrate A and obtains liquor B with step (3) and cleaning mixture mixes, being evaporated to after mixing under the conditions of 60 DEG C survey relative density is the extractum of 1.20-1.25；
(5): the extractum that Caulis Spatholobi extract step (1) obtained obtains with step (4) is mixed homogeneously, and is spray-dried, inlet temperature 80-120 DEG C, outlet temperature 45-80 DEG C, wind speed 5-10m/s, pressure 0.02-0.1kPa；Dried powder is crossed 100-200 mesh sieve, to obtain final product.
The source of component used by the present invention, nature and flavor, return through and effect:
Caulis Spatholobi: this product is the plant of pulse family Millettia, bitter in the mouth, sweet, warm in nature；Return liver, kidney channel；Enrich blood, invigorate blood circulation, dredging collateral；Relaxing muscles and tendons to promote blood circulation, nourishing blood for regulating menstruation.
Indigo Naturalis: for rank of nobility dinner party section plant Acanthaceous indigo, polygonaceae plant polygonum tinctorium ait., the leaf of cruciferae isatis or the processed prepared dried powder of stem and leaf, agglomerate or granule, salty in the mouth, cold in nature；Return Liver Channel；Tool heat-clearing and toxic substances removing, removing heat from blood dissipate swollen, the effect of pathogenic fire purging arresting convulsion.
Corium Erinacei Seu Hemiechianus: this product is the dry crust of Erinaceidae animal Rrinaceus earopaeus；Bitter in the mouth, sweet, property is put down；Return stomach, large intestine, kidney channel；Clots absorbing pain relieving, hemostasis, controlling nocturnal emission with astringent drugs.
Periostracum Cicadae: exuviae shell when this product is the larva emergence of cicada Cryptotympana atrata Fabr.；Sweet in the mouth, cold in nature；Return lung, Liver Channel；Dissipate wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.
Fructus Gardeniae: this product is the fruit of Maguireothamnus speciosus Fructus Gardeniae；Bitter in the mouth, cold in nature；GUIXIN, lung, tri-jiao channel；Clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, reducing swelling and alleviating pain.
Auricularia Sophorae: this product is to parasitize the Auricularia on Sophora japonica L.；Bitter in the mouth, pungent, property is put down；Return liver, spleen, large intestine channel；Hemostasis；Dysentery relieving；Anticancer.
Sanguis Draxonis: this product is that resin that babassu Sanguis Draxonis fruit oozes out is processed to be made；Sweet in the mouth, salty, property is put down；GUIXIN, Liver Channel；Removing blood stasis and relieving pain, hemostasia and promoting granulation.
Calculus Bovis: this product is the cholelithiasis that Chordata Mammalia bovid cattle is dried；Mildly bitter flavor is the sweetest, cool in nature；Antipyretic, removing toxic substances.
Olibanum: this product is that the oleo-gum-resin that Burseraceae Boswellia carterii platymiscium Boswellia carterii is oozed out with its trunk skin zone wound is used as medicine；Acrid in the mouth, hardship, warm in nature；Enter the heart, liver, spleen channel；Promoting blood circulation and stopping pain.
Rhizoma Solani tuber osi root: the root and rhizome that leguminous plant indigofera fortunei Craib, pink indigo, Yichang Folium et Caulis Indigoferae Tinctoriae, Radix Indigoferae Carlesii, Shaanxi Folium et Caulis Indigoferae Tinctoriae, HUAMU are blue；Bitter in the mouth, has heat-clearing and toxic substances removing, dissipates swollen pain relieving.
Flos Lonicerae: this product is dry flower or the first flower opened of band of caprifoliaceae plant Radix Ophiopogonis；Sweet in the mouth, cold in nature；Return lung, the heart, stomach warp；Heat-clearing and toxic substances removing, wind-heat dissipating.
The Radix Angelicae Dahuricae: this product is the dry root of the umbellate form section plant Radix Angelicae Dahuricae；Acrid in the mouth, warm in nature；Return stomach, large intestine, lung meridian；Dissipate wind dehumidifying, sensible pain relieving, detumescence and apocenosis.
Fructus Forsythiae: this product is the dry fruit of Oleaceae plants Fructus Forsythiae；Bitter in the mouth, cold nature；Return lung, the heart, small intestine meridian；Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.
Cortex toonae sinensis radicis: this product is Meliaceae plant bark of Toona sinensis or the phloem of root bark；Bitter and puckery flavor, cool in nature；Return large intestine, stomach warp；Heat clearing and damp drying, astringing intestine to stop diarrhea, hemostasis.
Moschus: this product is the dry secretions in animal in deer family woods Moschus moschiferous, horse Moschus moschiferous or former Moschus moschiferous maturation hero body note capsule；Acrid in the mouth, warm in nature；GUIXIN, spleen channel；Have one's ideas straightened out refreshment, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain.
Lasiosphaera Seu Calvatia: this product belongs to basidiomycetes Lycoperdaceae；Acrid in the mouth, property is put down；Lung heat clearing, detoxify, stop blooding.
Herba Corydalis Bungeanae: this product is the herb of Papaveraceae Genus Corydalis Herba Corydalis Bungeanae；Bitter in the mouth, cold in nature；GUIXIN, spleen channel；Heat-clearing and toxic substances removing, promoting blood circulation and detumescence.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down；GUIXIN, lung, spleen, stomach warp；Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Compared with prior art, the present invention has a following technical advantage:
1, Chinese medicine composition prepared by the present invention is compared with the medicine of other treatment hemorrhoid, and at heat-clearing and toxic substances removing, removing blood stasis and relieving pain, the aspect such as hemostasia and promoting granulation, detumescence and apocenosis and promoting blood circulation to restore menstrual flow has more remarkable efficacy.
2, compared with the chemotherapeutic agent of Current therapeutic hemorrhoid, Chinese medicine composition prepared by the present invention is natural pure Chinese medicinal preparation, untoward reaction and side effect significantly reduce, Chinese medicine composition effect is comprehensive, medication effect is more preferably, efficiently solve the morbidity root of hemorrhoid, and improve the quality of life of patient.
The advantages such as 3, Chinese medicine composition prepared by the present invention also has that compatibility science, preparation technology be simple, good effect, side effect are low, taking convenience and application easy to spread.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following example represents the technology playing good action in the practice of the invention that the inventors discovered that.But, disclosed specific embodiments can be made many changes, and still obtain same or analogous result, without departing from the spirit and scope of the present invention.
Embodiment
1
:
By following weight portion weighting raw materials: Caulis Spatholobi 5 parts, Indigo Naturalis 4 parts, Corium Erinacei Seu Hemiechianus 5 parts, Periostracum Cicadae 5 parts, Fructus Gardeniae 1 part, Auricularia Sophorae 5 parts, Sanguis Draxonis 3 parts, Calculus Bovis 3 parts, Olibanum 8 parts, Rhizoma Solani tuber osi root 6 parts, Flos Lonicerae 8 parts, the Radix Angelicae Dahuricae 5 parts, Fructus Forsythiae 8 parts, Cortex toonae sinensis radicis 8 parts, 2 parts of Moschus, Lasiosphaera Seu Calvatia 5 parts, Herba Corydalis Bungeanae 11 parts and 3 parts of Radix Glycyrrhizae.
Preparation method is as follows:
(1): take Caulis Spatholobi, wash away impurity, crushed after being dried, crosses 80 mesh sieves, and adding Caulis Spatholobi coarse powder gross weight 8 times amount volume fraction is the ethanol of 60%, add the cellulase of Caulis Spatholobi coarse powder total amount 0.8%, extract at 38 DEG C 1 hour, then 85 DEG C of reflux, extract, 1 hour, filter and retain Caulis Spatholobi filtering residue, filtrate reduced in volume is the extractum of 1.10 to relative density at 60 DEG C, obtains Caulis Spatholobi extract；
(2): take Indigo Naturalis, Corium Erinacei Seu Hemiechianus, Periostracum Cicadae, Fructus Gardeniae, Auricularia Sophorae, Sanguis Draxonis, Calculus Bovis, Olibanum, Rhizoma Solani tuber osi root, Flos Lonicerae, the Radix Angelicae Dahuricae, Fructus Forsythiae, Cortex toonae sinensis radicis, Moschus moschiferous is fragrant, Lasiosphaera Seu Calvatia, Herba Corydalis Bungeanae and Radix Glycyrrhizae, wash away impurity, crushed after being dried, the Caulis Spatholobi medicinal residues obtained with step (1) mix, add the water of above-mentioned coarse powder total amount 15 times amount, soak 20 minutes, reflux, extract, 2 times, each 1 hour, filter, merging filtrate, filtrate reduced in volume is the extractum of 1.10 to surveying relative density at 60 DEG C, cooling, it is slowly added to ethanol while stirring to alcohol content for reaching 40%, 4 DEG C stand 12 hours, filter and retain filtering residue, obtain filtrate A；
(3): the filtering residue that step (2) obtains is slowly added to filtering residue weight 4 times amount volume fraction while stirring is the ethanol of 40%, 4 DEG C stand 3 hours, filter, obtain liquor B and filtering residue；Filtering residue again with 40% washing with alcohol 2 times, collect and merge cleaning mixture；
(4): liquor B and cleaning mixture that filtrate A step (2) obtained obtains with step (3) mix, being evaporated to after mixing under the conditions of 60 DEG C survey relative density is the extractum of 1.20；
(5): the extractum that Caulis Spatholobi extract step (1) obtained obtains with step (4) mixes, and is spray-dried, inlet temperature 80 DEG C, outlet temperature 45 DEG C, wind speed 5m/s, pressure 0.02kPa；Dried powder is crossed 100 mesh sieves, adds corresponding adjuvant, make capsule.
Embodiment
2
:
By following weight portion weighting raw materials: Caulis Spatholobi 15 parts, Indigo Naturalis 12 parts, Corium Erinacei Seu Hemiechianus 12 parts, Periostracum Cicadae 12 parts, Fructus Gardeniae 5 parts, Auricularia Sophorae 11 parts, Sanguis Draxonis 7 parts, Calculus Bovis 7 parts, Olibanum 14 parts, Rhizoma Solani tuber osi root 12 parts, Flos Lonicerae 17 parts, the Radix Angelicae Dahuricae 11 parts, Fructus Forsythiae 17 parts, Cortex toonae sinensis radicis 17 parts, 3 parts of Moschus, Lasiosphaera Seu Calvatia 10 parts, Herba Corydalis Bungeanae 17 parts and 12 parts of Radix Glycyrrhizae.
Preparation method is as follows:
(1): take Caulis Spatholobi, wash away impurity, crushed after being dried, crosses 100 mesh sieves, and adding Caulis Spatholobi coarse powder gross weight 9 times amount volume fraction is the ethanol of 70%, add the cellulase of Caulis Spatholobi coarse powder total amount 0.9%, extract at 43 DEG C 2 hours, then 90 DEG C of reflux, extract, 2 hours, filter and retain Caulis Spatholobi filtering residue, filtrate reduced in volume is the extractum of 1.20 to relative density at 60 DEG C, prepares Caulis Spatholobi extract；
(2): take Indigo Naturalis, Corium Erinacei Seu Hemiechianus, Periostracum Cicadae, Fructus Gardeniae, Auricularia Sophorae, Sanguis Draxonis, Calculus Bovis, Olibanum, Rhizoma Solani tuber osi root, Flos Lonicerae, the Radix Angelicae Dahuricae, Fructus Forsythiae, Cortex toonae sinensis radicis, Moschus moschiferous is fragrant, Lasiosphaera Seu Calvatia, Herba Corydalis Bungeanae and Radix Glycyrrhizae, wash away impurity, crushed after being dried, the Caulis Spatholobi medicinal residues obtained with step (1) mix, add the water of above-mentioned coarse powder total amount 18 times amount, soak 25 minutes, reflux, extract, 2 times, each 2 hours, filter, merging filtrate, filtrate reduced in volume is the extractum of 1.15 to surveying relative density at 60 DEG C, cooling, it is slowly added to ethanol while stirring to alcohol content for reaching 50%, 4 DEG C stand 18 hours, filter and retain filtering residue, obtain filtrate A；
(3): the filtering residue that step (2) obtains is slowly added to filtering residue weight 5 times amount volume fraction while stirring is the ethanol of 50%, 4 DEG C stand 4 hours, filter, obtain liquor B and filtering residue；Filtering residue again with 50% washing with alcohol 2 times, collect and merge cleaning mixture；
(4): liquor B and cleaning mixture that filtrate A step (2) obtained obtains with step (3) mix, being evaporated to after mixing under the conditions of 60 DEG C survey relative density is the extractum of 1.22；
(5): the extractum that Caulis Spatholobi extract step (1) obtained obtains with step (4) mixes, and is spray-dried, inlet temperature 100 DEG C, outlet temperature 60 DEG C, wind speed 8m/s, pressure 0.08kPa；Dried powder is crossed 120 mesh sieves, adds corresponding adjuvant, make granule.
Embodiment
3
:
By following weight portion weighting raw materials: Caulis Spatholobi 8 parts, Indigo Naturalis 7 parts, Corium Erinacei Seu Hemiechianus 9 parts, Periostracum Cicadae 10 parts, Fructus Gardeniae 3 parts, Auricularia Sophorae 8 parts, Sanguis Draxonis 5 parts, Calculus Bovis 4 parts, Olibanum 12 parts, Rhizoma Solani tuber osi root 8 parts, Flos Lonicerae 13 parts, the Radix Angelicae Dahuricae 9 parts, Fructus Forsythiae 16 parts, Cortex toonae sinensis radicis 14 parts, 2 parts of Moschus, Lasiosphaera Seu Calvatia 8 parts, Herba Corydalis Bungeanae 15 parts and 8 parts of Radix Glycyrrhizae.
Preparation method is as follows:
(1): take Caulis Spatholobi, wash away impurity, crushed after being dried, crosses 100 mesh sieves, and adding Caulis Spatholobi coarse powder gross weight 10 times amount volume fraction is the ethanol of 80%, add the cellulase of Caulis Spatholobi coarse powder total amount 1.2%, extract at 45 DEG C 2 hours, then 95 DEG C of reflux, extract, 2 hours, filter and retain Caulis Spatholobi filtering residue, filtrate reduced in volume is the extractum of 1.25 to relative density at 60 DEG C, obtains Caulis Spatholobi extract；
(2): take Indigo Naturalis, Corium Erinacei Seu Hemiechianus, Periostracum Cicadae, Fructus Gardeniae, Auricularia Sophorae, Sanguis Draxonis, Calculus Bovis, Olibanum, Rhizoma Solani tuber osi root, Flos Lonicerae, the Radix Angelicae Dahuricae, Fructus Forsythiae, Cortex toonae sinensis radicis, Moschus moschiferous is fragrant, Lasiosphaera Seu Calvatia, Herba Corydalis Bungeanae and Radix Glycyrrhizae, wash away impurity, crushed after being dried, the Caulis Spatholobi medicinal residues obtained with step (1) mix, add the water of above-mentioned coarse powder total amount 20 times amount, soak 30 minutes, reflux, extract, 3 times, each 3 hours, filter, merging filtrate, filtrate reduced in volume is the extractum of 1.20 to surveying relative density at 60 DEG C, cooling, it is slowly added to ethanol while stirring to alcohol content for reaching 60%, 4 DEG C stand 24 hours, filter and retain filtering residue, obtain filtrate A；
(3): the filtering residue that step (2) obtains is slowly added to filtering residue weight 6 times amount volume fraction while stirring is the ethanol of 60%, 4 DEG C stand 5 hours, filter, obtain liquor B and filtering residue；Filtering residue again with 60% washing with alcohol 3 times, collect and merge cleaning mixture；
(4): liquor B and cleaning mixture that filtrate A step (2) obtained obtains with step (3) mix, being evaporated to after mixing under the conditions of 60 DEG C survey relative density is the extractum of 1.25；
(5): the extractum that Caulis Spatholobi extract step (1) obtained obtains with step (4) mixes, and is spray-dried, inlet temperature 120 DEG C, outlet temperature 80 DEG C, wind speed 10m/s, pressure 0.1kPa；Dried powder is crossed 200 mesh sieves, adds corresponding adjuvant, make pill.
Clinical observation on the therapeutic effect
1, case selection: in 120 example hemorrhoid clinical volunteers patients, male patient 70 example, female patient 50 example, age bracket is 18-65 year, and 40 years old mean age, all patients is respectively provided with typical hemorrhoid symptom, and no difference of science of statistics in sex, age, the course of disease.
2, diagnostic criteria:
(1) tcm diagnosis standard: " the Chinese medical disease Standardization of diagnosis and curative effect " issued according to State Administration of Traditional Chinese Medicine: have anal abscess medical history；Focus has collar extension, pipeline, internal orifice to levy.
(2) Western medicine diagnose standard: 1. intermittence just time podex hemorrhage, show as defecate band blood, dye paper, bleed or penetrate blood；
2., after stool or fatigue, have outside cystic mass abjection anus, can self-resetting or need manual reduction maybe can not reset；3. podex has foreign body sensation, does not accommodate pain with falling inflation；4. show color cystic mass on tooth trace, before being common in the right side, behind the right side, left side, surface mucous is congested, rotten to the corn or has fibrosis lesion；5. mulberry cystic mass at anal canal and anus edge, or burst ecchymosis or thrombosis.
3, exclusion standard: 1. other diseases, syndrome or complication；Associated treatment possible influential effect observation index are the most accepted；3. other physiology with energy influential effect index observation, judged or pathological condition；4. severe cardiac, liver, kidney, hematological affect drug metabolism；5. characterizing population group's (edge design women, psychosis).Before including in, accepting Drug therapy, meet inclusive criteria through eluting after date, be not intended as Excluded cases.
4, standard is exited: do not implement intervening measure by regulation, it is impossible to judge curative effect.2. data does not judges curative effect, safety completely without method.3. serious adverse reaction, complication, special physiological change etc., it is difficult to continual cure.(untoward reaction person includes bad reflection statistics in).4. the medicine that affects the treatment is used.Exit/come off case and include efficacy determination in by curative effect when exiting/come off.
5, efficacy assessment standard:
Cure: abjection or the symptom such as have blood in stool does not occurs in patient, nevus core atrophy or be wholly absent；
Effective: abjection or the symptom such as have blood in stool does not occurs in patient, and nevus core is obviously reduced；
Invalid: symptom is not improved；
Total effective rate=(cure+effectively)/total number of cases × 100%.
6, instructions of taking: 120 patients are randomly divided into 2 groups, often organizes 60 people, respectively treatment group and matched group, and treatment group takes the pill that the embodiment of the present invention 3 prepares, each 3g, three times a day, serve on two weeks.Matched group takes SANQI HUAZHI WAN (Guangzhou Baiyunshan Zhongyi Pharmaceutical Co., Ltd., traditional Chinese medicines quasi-word 02Z12442), each 3g, 2-3 time on the one, serve on two weeks.
7, therapeutic outcome: as shown in table 1.
Table 1 therapeutic outcome
This test uses SANQI HUAZHI WAN as a control group, and the therapeutic effect of the Chinese medicine composition prepared with the present invention compares, it can be seen that the curative effect of traditional Chinese medicine composition for treating hemorrhoid prepared by the present invention.Make inventor surprisingly, the cure rate of Chinese medicine composition prepared by the present invention reaches 85%, total effective rate more than 90.0%, cure rate and total effective rate far above matched group, visible, Chinese medicine composition prepared by the present invention curative effect of medicine that particularly embodiment 3 prepares is good, and cure rate is high, can be as the drug use for the treatment of hemorrhoid.
Owing to describing the present invention by above preferred embodiment, in the spirit and/or scope of the present invention, the present invention is implemented in any replacement/for the present invention or combination, will be apparent from for a person skilled in the art, and is included among the present invention.
Claims (5)
1. the method for Chinese medicine composition preparing treatment hemorrhoid, it is characterised in that described preparation method comprises following step:
(1): weigh weight portion Caulis Spatholobi 5-15 part, wash away impurity, crushed after being dried, crosses 80-100 mesh sieve, and adding Caulis Spatholobi coarse powder gross weight 8-10 times amount volume fraction is the ethanol of 60-80%, add the cellulase of Caulis Spatholobi coarse powder total amount 0.8%-1.2%, extract 1-2 hour at 38-45 DEG C, then 85-95 DEG C of reflux, extract, 1-2 hour, filter and retain Caulis Spatholobi filtering residue, filtrate reduced in volume is the extractum of 1.10-1.25 to relative density at 60 DEG C, obtains Caulis Spatholobi extract；
null(2): weigh weight portion Indigo Naturalis 4-12 part、Corium Erinacei Seu Hemiechianus 5-12 part、Periostracum Cicadae 5-12 part、Fructus Gardeniae 1-5 part、Auricularia Sophorae 5-11 part、Sanguis Draxonis 3-7 part、Calculus Bovis 3-7 part、Olibanum 8-14 part、Rhizoma Solani tuber osi root 6-12 part、Flos Lonicerae 8-17 part、Radix Angelicae Dahuricae 5-11 part、Fructus Forsythiae 8-17 part、Cortex toonae sinensis radicis 8-17 part、Moschus 2-3 part、Lasiosphaera Seu Calvatia 5-10 part、Herba Corydalis Bungeanae 11-17 part and Radix Glycyrrhizae 3-12 part，Wash away impurity，Crushed after being dried，The Caulis Spatholobi medicinal residues obtained with step (1) mix，Add the water of above-mentioned coarse powder total amount 15-20 times amount，Soak 20-30 minute，Reflux, extract, 2-3 time，1-3 hour every time，Filter，Merging filtrate，Concentrating filtrate to survey relative density at 60 DEG C is the extractum of 1.10-1.20，Cooling，It is slowly added to ethanol while stirring to alcohol content for reaching 40-60%，4 DEG C stand 12-24 hour，Filter and retain filtering residue，Obtain filtrate A；
(3): it is the ethanol of 40-60% that the filtering residue that step (2) obtains is slowly added to filtering residue weight 4-6 times amount volume fraction while stirring, 4 DEG C stand 3-5 hour, filter, obtain liquor B and filtering residue；Filtering residue by washing with alcohol 2-3 time of 40-60%, is collected and merges cleaning mixture again；
(4): step (2) obtains filtrate A and obtains liquor B with step (3) and cleaning mixture mixes, being evaporated to after mixing under the conditions of 60 DEG C survey relative density is the extractum of 1.20-1.25；
(5): the extractum that Caulis Spatholobi extract step (1) obtained obtains with step (4) is mixed homogeneously, and is spray-dried, inlet temperature 80-120 DEG C, outlet temperature 45-80 DEG C, wind speed 5-10m/s, pressure 0.02-0.1kPa；Dried powder is crossed 100-200 mesh sieve, to obtain final product.
2. the method for the Chinese medicine composition of preparation treatment hemorrhoid as claimed in claim 1; it is characterized in that, the weight portion of the raw material of described Chinese medicine composition is as follows: Caulis Spatholobi 5 parts, Indigo Naturalis 4 parts, Corium Erinacei Seu Hemiechianus 5 parts, Periostracum Cicadae 5 parts, Fructus Gardeniae 1 part, Auricularia Sophorae 5 parts, Sanguis Draxonis 3 parts, Calculus Bovis 3 parts, Olibanum 8 parts, Rhizoma Solani tuber osi root 6 parts, Flos Lonicerae 8 parts, the Radix Angelicae Dahuricae 5 parts, Fructus Forsythiae 8 parts, Cortex toonae sinensis radicis 8 parts, 2 parts of Moschus, Lasiosphaera Seu Calvatia 5 parts, Herba Corydalis Bungeanae 11 parts and 3 parts of Radix Glycyrrhizae.
3. the method for the Chinese medicine composition of preparation treatment hemorrhoid as claimed in claim 1; it is characterized in that, the weight portion of the raw material of described Chinese medicine composition is as follows: Caulis Spatholobi 15 parts, Indigo Naturalis 12 parts, Corium Erinacei Seu Hemiechianus 12 parts, Periostracum Cicadae 12 parts, Fructus Gardeniae 5 parts, Auricularia Sophorae 11 parts, Sanguis Draxonis 7 parts, Calculus Bovis 7 parts, Olibanum 14 parts, Rhizoma Solani tuber osi root 12 parts, Flos Lonicerae 17 parts, the Radix Angelicae Dahuricae 11 parts, Fructus Forsythiae 17 parts, Cortex toonae sinensis radicis 17 parts, 3 parts of Moschus, Lasiosphaera Seu Calvatia 10 parts, Herba Corydalis Bungeanae 17 parts and 12 parts of Radix Glycyrrhizae.
4. the method for the Chinese medicine composition of preparation treatment hemorrhoid as claimed in claim 1; it is characterized in that, the weight portion of the raw material of described Chinese medicine composition is as follows: Caulis Spatholobi 8 parts, Indigo Naturalis 7 parts, Corium Erinacei Seu Hemiechianus 9 parts, Periostracum Cicadae 10 parts, Fructus Gardeniae 3 parts, Auricularia Sophorae 8 parts, Sanguis Draxonis 5 parts, Calculus Bovis 4 parts, Olibanum 12 parts, Rhizoma Solani tuber osi root 8 parts, Flos Lonicerae 13 parts, the Radix Angelicae Dahuricae 9 parts, Fructus Forsythiae 16 parts, Cortex toonae sinensis radicis 14 parts, 2 parts of Moschus, Lasiosphaera Seu Calvatia 8 parts, Herba Corydalis Bungeanae 15 parts and 8 parts of Radix Glycyrrhizae.
5. the method for the Chinese medicine composition of the preparation treatment hemorrhoid as described in claim 1-4 is arbitrary, it is characterised in that: described Chinese medicine composition is made into capsule, granule, tablet or pill.
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| CN1554377A (en) * | 2003-12-22 | 2004-12-15 | 阎怀玉 | Chinese herbal medicine for treating piles |
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| CN101474379A (en) * | 2008-12-01 | 2009-07-08 | 熊绍才 | Externally applied medicine for treating hemorrhoid |
| CN103393873A (en) * | 2013-08-15 | 2013-11-20 | 梁国才 | External medicine for treating hemorrhoid |
| CN104069248A (en) * | 2014-06-23 | 2014-10-01 | 曹松 | Traditional Chinese medicine composition for treating hemorrhoids |
| CN104524164A (en) * | 2014-12-05 | 2015-04-22 | 广东聚智诚科技有限公司 | Traditional Chinese medicine preparation for treating pruritus and eczema papulosum and preparation method thereof |
| CN104547902A (en) * | 2014-12-24 | 2015-04-29 | 广东聚智诚科技有限公司 | Application of traditional Chinese preparation in preparation of drugs used for treating chronic enteritis and appendicitis |
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| CN104491213A (en) * | 2014-12-09 | 2015-04-08 | 夏征梅 | Traditional Chinese ointment for treating bedsores |
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