CN104524035A - Traditional Chinese medicine for treating prosopospasm and preparation method thereof - Google Patents
Traditional Chinese medicine for treating prosopospasm and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention discloses a traditional Chinese medicine for treating prosopospasm. The traditional Chinese medicine is mainly prepared from the following medicinal raw materials in parts by weight: 9-16 parts of astragalus membranaceus, 5-10 parts of radix rehmanniae praeparata, 9-15 parts of angelica sinensis, 10-18 parts of junci medulla, 6-10 parts of radix paeoniae alba, 8-12 parts of schisandra chinensis, 8-16 parts of semen ziziphi spinosae, 9-15 parts of poria cocos, 7-10 parts of codonopsis pilosula, 6-10 parts of licorice root, 8-15 parts of cynanchum paniculatum, 3-6 parts of goat horn, 7-14 parts of cinnamon and 9-15 parts of trichosanthes kirilowii maxim. The traditional Chinese medicine has the advantages of remarkable effect, stable drug effect and high clinical cure rate.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to the Chinese medicine and preparation method for the treatment of facial spasm.
Background technology
Facial spasm is that one is not independently twitched as feature with side facial muscle paroxysmal, the peripheral neuropathy of other positive signs of impassivity system.Show as a side surface part paroxysmal, scrambling, involuntary twitch clinically, more nervous, the exciting spasm of spirit is more serious more.This disease starts a lot of in orbicularis oculi, gradually to buccal and even whole half side face development, and reverse development more rare.Can aggravate because of tired, nervous, especially with obvious when speech, smile, can be spasticity time serious.The traditional Chinese medical science thinks that they are many due to prolonged illness impairment caused by overstrain heart spleen, or liver spleen blood deficiency causes wind syndrome due to blood-deficiency, and muscle arteries and veins loses supports and causes, and is often attributed to the sick category such as spasm syndrome, eyelid twitch.
Publication No. CN 103007024 A(application number 201310017818.X) Chinese patent literature disclose a kind of Chinese medicine composition for the treatment of facial spasm, this Chinese medicine composition is by Radix Craibiodendri, spend schefflera in vain, Rhizoma Corydalis Decumbentis, periplaneta americana, Rhizoma Menispermi, Scorpio, Polyporus, Bulbus Lilii, the Fructus Sophorae, Radix Glycyrrhizae are made.Publication No. CN 103656152 A(application number 201310653947.8) Chinese patent literature disclose a kind of Chinese medicine preparation for the treatment of facial spasm, this Chinese medicine preparation is made up of Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Concha Ostreae, Rhizoma Menispermi, Scorpio, Radix Angelicae Sinensis, the Radix Astragali, Rhizoma Chuanxiong, Bulbus Lilii, Radix Glycyrrhizae.Publication No. CN 103893321 A(application number 201410159704.3) Chinese patent literature disclose a kind of Chinese medicine for the treatment of facial spasm, this Chinese medicine is made up of Radix Linderae Glaucae, Radix haleniae ellipticae, Caulis Millettiae Reticulatae, Rhizoma Chuanxiong, Herba Hedyotis Lanceae, Herba Artemisiae Anomalae, Herba Equiseti Hiemalis, Folium Linderae strychnifoliae, Bombyx Batryticatus, Zaocys.
The treatment means that modern Western medicine is conventional, be mainly modus operandi, its risk is larger, recover slow, and somewhat expensive, therefore often use tcm therapy, traditional therapy is mainly by acupuncture or decoction, and therapeutic effect is not very desirable, so need a kind of new Be very effective ground of research Chinese medicine formula.
Summary of the invention
For the problem of prior art, the object of this invention is to provide a kind of Be very effective, take the Chinese medicine of the wide treatment facial spasm of safe and applicable.
Technical scheme of the present invention is:
The Chinese medicine for the treatment of facial spasm, is prepared from primarily of following bulk drugs, is weight portion: Radix Astragali 9-16; Radix Rehmanniae Preparata 5-10; Radix Angelicae Sinensis 9-15; Medulla Junci 10-18; Radix Paeoniae Alba 6-10; Fructus Schisandrae Chinensis 8-12; Semen Ziziphi Spinosae (parched) 8-16; Poria 9-15; Radix Codonopsis 7-10; Radix Glycyrrhizae 6-10; Radix Cynanchi Paniculati 8-15; Cornu Caprae seu Ovis 3-6; Cortex Cinnamomi 7-14; Fructus Trichosanthis 9-15.
Preferably: Radix Astragali 11-14; Radix Rehmanniae Preparata 6-9; Radix Angelicae Sinensis 11-13; Medulla Junci 12-16; Radix Paeoniae Alba 7-9; Fructus Schisandrae Chinensis 9-11; Semen Ziziphi Spinosae (parched) 10-14; Poria 11-13; Radix Codonopsis 8-9; Radix Glycyrrhizae 7-9; Radix Cynanchi Paniculati 10-13; Cornu Caprae seu Ovis 4-5; Cortex Cinnamomi 9-12; Fructus Trichosanthis 11-13.
More preferably: the Radix Astragali 12.5; Radix Rehmanniae Preparata 7.5; Radix Angelicae Sinensis 12; Medulla Junci 14; The Radix Paeoniae Alba 8; Fructus Schisandrae Chinensis 10; Semen Ziziphi Spinosae (parched) 12; Poria 12; Radix Codonopsis 8.5; Radix Glycyrrhizae 8; Radix Cynanchi Paniculati 11.5; Cornu Caprae seu Ovis 4.5; Cortex Cinnamomi 10.5; Fructus Trichosanthis 12.
The Chinese medicine of described treatment facial spasm, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get Bulbus Allii Fistulosi and add decocting soup, the Radix Astragali, Radix Angelicae Sinensis, Poria and Radix Codonopsis are cleaned, be placed in soup and soak 40 minutes, pull out, vexed after, cut into slices, dry;
(2) Fructus Schisandrae Chinensis is removed handle, sieve dedust bits, are rolled into cake, are placed in parch container, add rice wine and mix thoroughly, and slow fire stir-fries 5-10 minute (preferred: to stir-fry 8 minutes), takes out;
(Cornu Caprae seu Ovis is rasped to end by 3), and add the Mel submergence of medical material weight 5 times, little fire is endured to its variable color, smashs to pieces after flash baking;
(4) residue medical material is put into pot, the micro-stir-fry of little fire, taking-up cools, and mixes, pulverize and sieve with above-mentioned medical material, and encapsulation obtains powder.
The preparation method of the Chinese powder medicine of described treatment facial spasm, pulverized 140-180 mesh sieve (preferred: to cross 150-170 mesh sieve: be more preferably: to cross 160 mesh sieves) in step (4).
The Chinese medicine of described treatment facial spasm, be made into pharmaceutically acceptable pill, its preparation method is:
(1) get Bulbus Allii Fistulosi and add decocting soup, the Radix Astragali, Radix Angelicae Sinensis, Poria and Radix Codonopsis are cleaned, be placed in soup and soak 40 minutes, pull out, vexed after, cut into slices, dry;
(2) Fructus Schisandrae Chinensis is removed handle, sieve dedust bits, are rolled into cake, are placed in parch container, add rice wine and mix thoroughly, and slow fire stir-fries 5-10 minute (preferred: to stir-fry 8 minutes), takes out;
(Cornu Caprae seu Ovis is rasped to end by 3), and add the Mel submergence of medical material weight 5 times, little fire is endured to its variable color, smashs to pieces after flash baking;
(4) residue medical material is put into pot, the micro-stir-fry of little fire, taking-up cools, and mixes, pulverize with above-mentioned medical material, crosses 120 mesh sieves;
(5) get Mel heating to temper, make refined honey, then mix with medicated powder, integrate bar processed, ball is rubbed in segmentation with the hands, obtain pill.
The preparation method of the medicine pill of described treatment facial spasm, the weight ratio of step (5) Chinese medicine powder and refined honey is that 1:1-1:3(is preferred: the weight ratio of medicated powder and refined honey is 1:2).
The Chinese medicine of described treatment facial spasm, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Bulbus Allii Fistulosi and add decocting soup, the Radix Astragali, Radix Angelicae Sinensis, Poria and Radix Codonopsis are cleaned, be placed in soup and soak 40 minutes, pull out, vexed after, cut into slices, dry;
(2) Fructus Schisandrae Chinensis is removed handle, sieve dedust bits, are rolled into cake, are placed in parch container, add rice wine and mix thoroughly, and slow fire stir-fries 5-10 minute (preferred: to stir-fry 8 minutes), takes out;
(Cornu Caprae seu Ovis is rasped to end by 3), and add the Mel submergence of medical material weight 5 times, little fire is endured to its variable color, smashs to pieces after flash baking;
(4) cleaned by residue medical material, put into marmite, decoct with water twice, each decoction 40 minutes, filtered while hot also mixes twice gained filtrate;
(5) by step (1) (2) (3) made medical material, 130-160 mesh sieve was pulverized (preferred: to pulverize 140-150 mesh sieve; Be more preferably: pulverized 145 mesh sieves), then pour in step (4) gained filtrate, stir, sterilizing encapsulation obtains decoction.
The preparation method of the Chinese medicine decoction of described treatment facial spasm, in step (4), amount of water is the 6-8 of medical material weight doubly (preferred: amount of water is 7 times of medical material weight).
The Chinese medicine of described treatment facial spasm, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) get Bulbus Allii Fistulosi and add decocting soup, the Radix Astragali, Radix Angelicae Sinensis, Poria and Radix Codonopsis are cleaned, be placed in soup and soak 40 minutes, pull out, vexed after, cut into slices, dry;
(2) Fructus Schisandrae Chinensis is removed handle, sieve dedust bits, are rolled into cake, are placed in parch container, add rice wine and mix thoroughly, and slow fire stir-fries 5-10 minute (preferred: to stir-fry 8 minutes), takes out;
(Cornu Caprae seu Ovis is rasped to end by 3), and add the Mel submergence of medical material weight 5 times, little fire is endured to its variable color, smashs to pieces after flash baking;
(4) residue medical material is put into pot, the micro-stir-fry of little fire, taking-up cools, and mixes, pulverize and sieve with above-mentioned medical material, according to the processing method of tablet, is pressed into lamellar, is packaged to be tablet.
The preparation method of the Chinese medicinal tablet of described treatment facial spasm, pulverized 160-190 mesh sieve (preferred: to pulverize 170-180 mesh sieve in step (4); Be more preferably: pulverized 175 mesh sieves).
The Chinese medicine formula science for the treatment of facial spasm provided by the invention, preparation method is simple.In addition, its excellent part also shows:
1, the medical material selected by the present invention, is and has no side effect, and can use by safety clothes;
2, resulting dosage forms taking convenience, efficacy stability, clinical cure rate is high;
3, the present invention is directed to facial spasm, have supplementing QI for promoting the production of body fluid, effect of invigorating blood circulation of enriching blood.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
The Radix Astragali: property is sweet, tepor.Return lung, spleen, liver, kidney channel.There is effect that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema.Be generally used for the treatment deficiency of vital energy weak, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.
Radix Rehmanniae Preparata: base is former: for the rhizome of Radix Rehmanniae is celebrated in scrophulariaceae rehmannia glutinosa plant or bosom, steam solarization through processing and form.Nature and flavor with return through: sweet, tepor.Return liver, kidney channel.Function with cure mainly: YIN nourishing, enrich blood.Control deficiency of YIN insufficiency of blood, waist knee flaccidity, chronic cough hectic fever due to YIN-deficiency, seminal emission, metrorrhagia, menoxenia, quenches one's thirst, frequency of micturition, deaf, blurred vision.
Radix Angelicae Sinensis: nature and flavor with return through sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Medulla Junci: base is former: be the dry stem pith of rush family plant Medulla Junci.Nature and flavor with return through: sweet, light, be slightly cold.GUIXIN, lung, small intestine meridian.There is clearing away heart-fire, effect of diuresis.For vexed insomnia, the puckery pain of oliguria, aphtha of the mouth and tongue.
The Radix Paeoniae Alba: nature and flavor with return through, bitter, sour, be slightly cold.Return liver, spleen channel.There is nourishing blood for regulating menstruation, astringing YIN to stop sweating, easing the affected liver to relieve pain, stabilize effect of sun.For blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, stomachache, limb pain twin, has a headache dizzy.
Fructus Schisandrae Chinensis: nature and flavor with return through: sour, sweet, temperature.Woman's lung, the heart, kidney channel.There is convergence astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, effect of kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous sweating, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, palpitation and insomnia.
Semen Ziziphi Spinosae (parched): Semen Ziziphi Spinosae: nature and flavor with return through: sweet, sour, flat.Return liver, gallbladder, heart channel.Nourish heart tonifying liver, mind tranquilizing and the heart calming, arresting sweating, the effect of promoting the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.Semen Ziziphi Spinosae (parched): get clean Semen Ziziphi Spinosae, put in pot to fry with slow fire and to heave to crust and be micro-yellow, taking-up, cools.
Poria: nature and flavor with return through: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.There is promoting diuresis to eliminate damp pathogen, spleen invigorating, effect of mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Radix Codonopsis: nature and flavor with return through: sweet, flat.Return spleen, lung meridian.Function with cure mainly: spleen invigorating lung benefiting, nourishing blood to promote the production of body fluid.For deficiency of both the splenic and pulmonary QI, lack of appetite asthenia, cough dyspnea due to deficiency, insufficiency of vital energy and blood, shallow complexion, shortness of breath and palpitation, Tianjin wound is thirsty, and interior-heat is quenched one's thirst.
Radix Glycyrrhizae: sweet in the mouth, property is put down.There is QI invigorating invigorating middle warmer, relieving spasm to stop pain, effect of eliminating fire and detoxication, for the disease of laryngopharynx swelling and pain.
Radix Cynanchi Paniculati: base is former: be the dry root welding technology of Luo Mo section plant Radix Cynanchi Paniculati.Nature and flavor with return through: pungent, temperature.Return liver, stomach warp.Function with cure mainly: dispel the wind, removing dampness, pain relieving, antipruritic.For rheumatic arthralgia, stomachache distension, toothache, lumbago, falls and flutters the pain of injury, rubella, eczema.
Cornu Caprae seu Ovis: base is former: be the angle of bovid male goat or male sheep.Nature and flavor: salty are cool.Gui Jing: enter liver, heart channel.Function cures mainly: heat clearing away, relieving convulsion, improving eyesight, removing toxic substances.Control pediatric epilepsy scared, headache due to pathogenic wind-heat, unhappy, spit blood, optic atrohic blindness, toxic swelling.
Cortex Cinnamomi: base is former: be dried bark and the branch skin of canella Cortex Cinnamomi.Chemical analysis: skin is containing volatile oil (title Oleum Cinnamomi) 1 ~ 2%, and main component is cinnamic aldehyde 75 ~ 90%, and containing a small amount of acetic acid Cortex cinnamomi japonici (Ramulus Cinnamomi) ester, phenylpropyl acetate etc.This product is not containing eugenol.Still mucous, tannin etc.Nature and flavor: Xin Gan, heat.Gui Jing: enter kidney, spleen, urinary bladder channel.Function cures mainly: complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.
Fructus Trichosanthis: base is former: be the fruit of cucurbitaceous plant Fructus Trichosanthis.Chemical analysis: fruit is containing triterpenoid saponin, organic acid, resin, saccharide and pigment.The fatty oil of seed.Nature and flavor: sweetness and bitterness, cold.Gui Jing: enter lung, stomach, large intestine channel.Function cures mainly: lung moistening, reduces phlegm, eliminating stagnation, laxation.Control phlegm-heat cough, the thoracic obstruction, blocked-up chest, consumptive lung disease hemoptysis, quenches one's thirst, jaundice, constipation, carbuncle from the beginning of.
embodiment 1the Chinese medicine for the treatment of facial spasm, is prepared from primarily of following bulk drugs: Radix Astragali 9g, Radix Rehmanniae Preparata 5g, Radix Angelicae Sinensis 9g, Medulla Junci 10g, Radix Paeoniae Alba 6g, Fructus Schisandrae Chinensis 8g, Semen Ziziphi Spinosae (parched) 8g, Poria 9g, Radix Codonopsis 7g, Radix Glycyrrhizae 6g, Radix Cynanchi Paniculati 8g ， Cornu Caprae seu Ovis 3g, Cortex Cinnamomi 7g, Fructus Trichosanthis 9g.The preparation method of the Chinese powder medicine of above-mentioned treatment facial spasm is:
(1) get Bulbus Allii Fistulosi and add decocting soup, the Radix Astragali, Radix Angelicae Sinensis, Poria and Radix Codonopsis are cleaned, be placed in soup and soak 40 minutes, pull out, vexed after, cut into slices, dry;
(2) Fructus Schisandrae Chinensis is removed handle, sieve dedust bits, be rolled into cake, be placed in parch container, add rice wine and mix thoroughly, slow fire stir-fries 8 minutes, takes out;
(Cornu Caprae seu Ovis is rasped to end by 3), and add the Mel submergence of medical material weight 5 times, little fire is endured to its variable color, smashs to pieces after flash baking;
(4) residue medical material is put into pot, the micro-stir-fry of little fire, taking-up cools, and mixes with above-mentioned medical material, and pulverized 160 mesh sieve sieves, encapsulation obtains powder.
embodiment 2the Chinese medicine for the treatment of facial spasm, is prepared from primarily of following bulk drugs: Radix Astragali 16g, Radix Rehmanniae Preparata 10g, Radix Angelicae Sinensis 15g, Medulla Junci 18g, Radix Paeoniae Alba 10g, Fructus Schisandrae Chinensis 12g, Semen Ziziphi Spinosae (parched) 16g, Poria 15g, Radix Codonopsis 10g, Radix Glycyrrhizae 10g, Radix Cynanchi Paniculati 15g ， Cornu Caprae seu Ovis 6g, Cortex Cinnamomi 14g, Fructus Trichosanthis 15g.The preparation method of the medicine pill of above-mentioned treatment facial spasm is:
(1) get Bulbus Allii Fistulosi and add decocting soup, the Radix Astragali, Radix Angelicae Sinensis, Poria and Radix Codonopsis are cleaned, be placed in soup and soak 40 minutes, pull out, vexed after, cut into slices, dry;
(2) Fructus Schisandrae Chinensis is removed handle, sieve dedust bits, be rolled into cake, be placed in parch container, add rice wine and mix thoroughly, slow fire stir-fries 8 minutes, takes out;
(Cornu Caprae seu Ovis is rasped to end by 3), and add the Mel submergence of medical material weight 5 times, little fire is endured to its variable color, smashs to pieces after flash baking;
(4) residue medical material is put into pot, the micro-stir-fry of little fire, taking-up cools, and mixes, pulverize with above-mentioned medical material, crosses 120 mesh sieves;
(5) get Mel heating to temper, make refined honey, then mix with medicated powder (weight ratio of medicated powder and refined honey is 1:2), integrate bar processed, ball is rubbed in segmentation with the hands, obtain pill.
Model case: xxx, male, 34 years old.Main suit: left side facial muscle are not independently twitched more than a year repeatedly; Clinical symptoms: patient is in occurring that left side eyelid is beated without obvious inducement the year before, in paroxysmal, can not control, twitch rapidly, stop after last for several seconds, start not to be present to the mind, rear outbreak is frequent, gradually involves left side bicker, advises through household, carry out hospital admission, be diagnosed as facial spasm after inspection.
Because not agreeing to carry out operative treatment, recommending to take this example gained pill, each two balls, one day twice through people, five days is a course for the treatment of.After taking five days, symptom is clearly better, and takes ten days continuously, and twitch phenomenon and substantially eliminate, patient fully recovers, and follows up a case by regular visits in 1 year, occasionally has recurrence.
embodiment 3the Chinese medicine for the treatment of facial spasm, is prepared from primarily of following bulk drugs: Radix Astragali 11g, Radix Rehmanniae Preparata 6g, Radix Angelicae Sinensis 11g, Medulla Junci 12g, Radix Paeoniae Alba 7g, Fructus Schisandrae Chinensis 9g, Semen Ziziphi Spinosae (parched) 10g, Poria 11g, Radix Codonopsis 8g, Radix Glycyrrhizae 7g, Radix Cynanchi Paniculati 10g ， Cornu Caprae seu Ovis 4g, Cortex Cinnamomi 9g, Fructus Trichosanthis 11g.The preparation method of the Chinese medicine decoction of above-mentioned treatment facial spasm is:
(1) get Bulbus Allii Fistulosi and add decocting soup, the Radix Astragali, Radix Angelicae Sinensis, Poria and Radix Codonopsis are cleaned, be placed in soup and soak 40 minutes, pull out, vexed after, cut into slices, dry;
(2) Fructus Schisandrae Chinensis is removed handle, sieve dedust bits, be rolled into cake, be placed in parch container, add rice wine and mix thoroughly, slow fire stir-fries 8 minutes, takes out;
(Cornu Caprae seu Ovis is rasped to end by 3), and add the Mel submergence of medical material weight 5 times, little fire is endured to its variable color, smashs to pieces after flash baking;
(4) cleaned by residue medical material, put into marmite, add the soak by water twice of medical material weight 7 times, each decoction 40 minutes, filtered while hot also mixes twice gained filtrate;
(5) by step (1) (2) (3) made medical material, pulverized 145 mesh sieves, and then poured in step (4) gained filtrate, stir, sterilizing encapsulation obtains decoction.
Model case: xxx, women, 21 years old.Medical history: patient said good-bye with boyfriend before half a year, mood is more irritated, object for appreciation mobile phone of often staying up late, and the automatic tic of bicker appears in recent months, persistent period is also more and more longer, cause patient's temper more irascible, have a short fuse, appetite starts to decline, sleep poor, final under the company of friend, remove hospital admission, be found to be facial spasm after inspection.
Take this example gained decoction, each 40-80ml, warmly to take, one day twice five days is a course for the treatment of.After taking one week, the tic symptom of patient is eliminated substantially, and continue to take a course for the treatment of, the mental status is clearly better, and sleep quality improves, and after drug withdrawal in 1 year, does not recur.
embodiment 4the Chinese medicine for the treatment of facial spasm, is prepared from primarily of following bulk drugs: Radix Astragali 14g, Radix Rehmanniae Preparata 9g, Radix Angelicae Sinensis 13g, Medulla Junci 16g, Radix Paeoniae Alba 9g, Fructus Schisandrae Chinensis 11g, Semen Ziziphi Spinosae (parched) 14g, Poria 13g, Radix Codonopsis 9g, Radix Glycyrrhizae 9g, Radix Cynanchi Paniculati 13g ， Cornu Caprae seu Ovis 5g, Cortex Cinnamomi 12g, Fructus Trichosanthis 13g.The preparation method of the Chinese medicinal tablet of above-mentioned treatment facial spasm is:
(1) get Bulbus Allii Fistulosi and add decocting soup, the Radix Astragali, Radix Angelicae Sinensis, Poria and Radix Codonopsis are cleaned, be placed in soup and soak 40 minutes, pull out, vexed after, cut into slices, dry;
(2) Fructus Schisandrae Chinensis is removed handle, sieve dedust bits, be rolled into cake, be placed in parch container, add rice wine and mix thoroughly, slow fire stir-fries 8 minutes, takes out;
(Cornu Caprae seu Ovis is rasped to end by 3), and add the Mel submergence of medical material weight 5 times, little fire is endured to its variable color, smashs to pieces after flash baking;
(4) residue medical material is put into pot, the micro-stir-fry of little fire, taking-up cools, and mixes with above-mentioned medical material, pulverizes 175 mesh sieves, according to the processing method of tablet, is pressed into lamellar, is packaged to be tablet.
Model case: xxx, male, 16 years old.Medical history: before one month, the head of a family of patient finds that child often rubs eyes, the corners of the mouth occurs twitching phenomenon frequently, thinks that child deliberately attracts other people to note, is not present to the mind, just find that the twitch of child is uncontrolled subsequently, crooked the while of eye and mouth, the persistent period is longer, then sends to hospital admission, after inspection, facial spasm is diagnosed as.
Taking this example gained Chinese medicinal tablet, each three, warm boiled water, one day three times, five days is a course for the treatment of.After taking a course for the treatment of, symptom takes an evident turn for the better, and continues two courses for the treatment of of use, and patient twitches phenomenon and eliminates, and after drug withdrawal, follows up a case by regular visits in 1 year, does not occur recurrence.
embodiment 5the Chinese medicine for the treatment of facial spasm, is prepared from primarily of following bulk drugs: Radix Astragali 12.5g, Radix Rehmanniae Preparata 7.5g, Radix Angelicae Sinensis 12g, Medulla Junci 14g, Radix Paeoniae Alba 8g, Fructus Schisandrae Chinensis 10g, Semen Ziziphi Spinosae (parched) 12g, Poria 12g, Radix Codonopsis 8.5g, Radix Glycyrrhizae 8g, Radix Cynanchi Paniculati 11.5g ， Cornu Caprae seu Ovis 4.5g, Cortex Cinnamomi 10.5g, Fructus Trichosanthis 12g.The preparation method of the Chinese medicine of above-mentioned treatment facial spasm powder is:
(1) get Bulbus Allii Fistulosi and add decocting soup, the Radix Astragali, Radix Angelicae Sinensis, Poria and Radix Codonopsis are cleaned, be placed in soup and soak 40 minutes, pull out, vexed after, cut into slices, dry;
(2) Fructus Schisandrae Chinensis is removed handle, sieve dedust bits, be rolled into cake, be placed in parch container, add rice wine and mix thoroughly, slow fire stir-fries 8 minutes, takes out;
(Cornu Caprae seu Ovis is rasped to end by 3), and add the Mel submergence of medical material weight 5 times, little fire is endured to its variable color, smashs to pieces after flash baking;
(4) residue medical material is put into pot, the micro-stir-fry of little fire, taking-up cools, and mixes with above-mentioned medical material, and pulverized 160 mesh sieve sieves, encapsulation obtains powder.
test example 1the clinical practice of the Chinese powder medicine of embodiment 5 gained treatment facial spasm:
Choose crowd: " the Chinese medical disease Standardization of diagnosis and curative effect " issued according to State Administration of Traditional Chinese Medicine: side face spasm is main, first occurs in orbicularis oculi, gradually to facial bicker muscle and platysma expansion; Each tic last for several seconds to several minutes, aggravates when tired, psychentonia, autonomic movement, can not control voluntarily, disappear after falling asleep; Facial mild pain can be accompanied during tic.The general no positive sign of nervous system; Unable and the slight atrophy of Ipsilateral facial muscle can be there is in a few patients later stage.Electroencephalogram and every inspection normally, get rid of the facial spasm caused by other reason.Screening facial spasm patient 346 example, wherein women 147 example, male 199 example, the range of age 15-60 year, the mean age is 37.5 years old, the course of disease at 2 months in 5 years.
Before test, patient is divided into two groups at random, experimental group 200 example and matched group 146 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference.Experimental group takes embodiment 5 gained Chinese powder medicine, each 5g, and sooner or later respectively once, warm boiled water five days is a course for the treatment of; Matched group takes other conventional medicines (Semen daturae, phenytoin Sodium, carbamazepine or operative treatment etc.).Period in a medicine carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect determinate standard: (1) cures: face spasm disappears completely, followed up a case by regular visits to without recurrence through 1 year; Effective: face spasm substantially disappears or obviously alleviates; (2) effective: face spasm has and alleviates in various degree, attack times, decreased duration; (3) invalid: before and after treatment, face spasm symptom is without changing or increasing the weight of.
Clinical effectiveness: after the taking medicine of three courses for the treatment of, the therapeutic effect of two groups is as shown in table 1:
It can thus be appreciated that the total effective rate of experimental group is 98.5%, the total effective rate of matched group is 89.1%, visible gained Chinese medicine of the present invention for the therapeutic effect of facial spasm higher than conventional medicine.
The Chinese medicine used in the present invention, the menstruction regulating and pain relieving of the benefiting QI for strengthening the superficies of the Radix Astragali, the nourishing YIN and supplementing blood of Radix Rehmanniae Preparata, Radix Angelicae Sinensis, convenient, the tonifying liver that nourishes heart of Semen Ziziphi Spinosae (parched) of relieving inflammation or internal heat of Medulla Junci, the mind calming spleen invigorating of Poria, the nourishing blood to promote the production of body fluid of Radix Codonopsis, the QI invigorating invigorating middle warmer of Radix Glycyrrhizae, the wind-expelling pain-stopping of Radix Cynanchi Paniculati, the YANG invigorating warming the stomach of Cortex Cinnamomi, the moistening the lung and resolving phlegm of Fructus Trichosanthis, for the disease of facial spasm, there is significant curative effect, all medicines share, can effectively alleviate uncomfortable disease, thus raising clinical cure rate, make total effective rate to reach 98.5%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat the Chinese medicine of facial spasm, it is characterized in that, be prepared from primarily of following bulk drugs, be weight portion: Radix Astragali 9-16; Radix Rehmanniae Preparata 5-10; Radix Angelicae Sinensis 9-15; Medulla Junci 10-18; Radix Paeoniae Alba 6-10; Fructus Schisandrae Chinensis 8-12; Semen Ziziphi Spinosae (parched) 8-16; Poria 9-15; Radix Codonopsis 7-10; Radix Glycyrrhizae 6-10; Radix Cynanchi Paniculati 8-15; Cornu Caprae seu Ovis 3-6; Cortex Cinnamomi 7-14; Fructus Trichosanthis 9-15.
2. the Chinese medicine for the treatment of facial spasm as claimed in claim 1, is characterized in that, Radix Astragali 11-14; Radix Rehmanniae Preparata 6-9; Radix Angelicae Sinensis 11-13; Medulla Junci 12-16; Radix Paeoniae Alba 7-9; Fructus Schisandrae Chinensis 9-11; Semen Ziziphi Spinosae (parched) 10-14; Poria 11-13; Radix Codonopsis 8-9; Radix Glycyrrhizae 7-9; Radix Cynanchi Paniculati 10-13; Cornu Caprae seu Ovis 4-5; Cortex Cinnamomi 9-12; Fructus Trichosanthis 11-13(is preferably: the Radix Astragali 12.5; Radix Rehmanniae Preparata 7.5; Radix Angelicae Sinensis 12; Medulla Junci 14; The Radix Paeoniae Alba 8; Fructus Schisandrae Chinensis 10; Semen Ziziphi Spinosae (parched) 12; Poria 12; Radix Codonopsis 8.5; Radix Glycyrrhizae 8; Radix Cynanchi Paniculati 11.5; Cornu Caprae seu Ovis 4.5; Cortex Cinnamomi 10.5; Fructus Trichosanthis 12).
3. the Chinese medicine of the treatment facial spasm as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get Bulbus Allii Fistulosi and add decocting soup, the Radix Astragali, Radix Angelicae Sinensis, Poria and Radix Codonopsis are cleaned, be placed in soup and soak 40 minutes, pull out, vexed after, cut into slices, dry;
(2) Fructus Schisandrae Chinensis is removed handle, sieve dedust bits, are rolled into cake, are placed in parch container, add rice wine and mix thoroughly, and slow fire stir-fries 5-10 minute (preferred: to stir-fry 8 minutes), takes out;
(Cornu Caprae seu Ovis is rasped to end by 3), and add the Mel submergence of medical material weight 5 times, little fire is endured to its variable color, smashs to pieces after flash baking;
(4) residue medical material is put into pot, the micro-stir-fry of little fire, taking-up cools, and mixes, pulverize and sieve with above-mentioned medical material, and encapsulation obtains powder.
4. the preparation method of the Chinese powder medicine for the treatment of facial spasm as claimed in claim 3, is characterized in that, pulverizes 140-180 mesh sieve (preferred: to cross 150-170 mesh sieve: be more preferably: to cross 160 mesh sieves) in step (4).
5. the Chinese medicine of the treatment facial spasm as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable pill, its preparation method is:
(1) get Bulbus Allii Fistulosi and add decocting soup, the Radix Astragali, Radix Angelicae Sinensis, Poria and Radix Codonopsis are cleaned, be placed in soup and soak 40 minutes, pull out, vexed after, cut into slices, dry;
(2) Fructus Schisandrae Chinensis is removed handle, sieve dedust bits, are rolled into cake, are placed in parch container, add rice wine and mix thoroughly, and slow fire stir-fries 5-10 minute (preferred: to stir-fry 8 minutes), takes out;
(Cornu Caprae seu Ovis is rasped to end by 3), and add the Mel submergence of medical material weight 5 times, little fire is endured to its variable color, smashs to pieces after flash baking;
(4) residue medical material is put into pot, the micro-stir-fry of little fire, taking-up cools, and mixes, pulverize with above-mentioned medical material, crosses 120 mesh sieves;
(5) get Mel heating to temper, make refined honey, then mix with medicated powder, integrate bar processed, ball is rubbed in segmentation with the hands, obtain pill.
6. the preparation method of the medicine pill for the treatment of facial spasm as claimed in claim 5, it is characterized in that, the weight ratio of step (5) Chinese medicine powder and refined honey is that 1:1-1:3(is preferred: the weight ratio of medicated powder and refined honey is 1:2).
7. the Chinese medicine of the treatment facial spasm as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Bulbus Allii Fistulosi and add decocting soup, the Radix Astragali, Radix Angelicae Sinensis, Poria and Radix Codonopsis are cleaned, be placed in soup and soak 40 minutes, pull out, vexed after, cut into slices, dry;
(2) Fructus Schisandrae Chinensis is removed handle, sieve dedust bits, are rolled into cake, are placed in parch container, add rice wine and mix thoroughly, and slow fire stir-fries 5-10 minute (preferred: to stir-fry 8 minutes), takes out;
(Cornu Caprae seu Ovis is rasped to end by 3), and add the Mel submergence of medical material weight 5 times, little fire is endured to its variable color, smashs to pieces after flash baking;
(4) cleaned by residue medical material, put into marmite, decoct with water twice, each decoction 40 minutes, filtered while hot also mixes twice gained filtrate;
(5) by step (1) (2) (3) made medical material, 130-160 mesh sieve was pulverized (preferred: to pulverize 140-150 mesh sieve; Be more preferably: pulverized 145 mesh sieves), then pour in step (4) gained filtrate, stir, sterilizing encapsulation obtains decoction.
8. the preparation method of the Chinese medicine decoction for the treatment of facial spasm as claimed in claim 7, is characterized in that, in step (4), amount of water is the 6-8 of medical material weight doubly (preferred: amount of water is 7 times of medical material weight).
9. the Chinese medicine of the treatment facial spasm as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) get Bulbus Allii Fistulosi and add decocting soup, the Radix Astragali, Radix Angelicae Sinensis, Poria and Radix Codonopsis are cleaned, be placed in soup and soak 40 minutes, pull out, vexed after, cut into slices, dry;
(2) Fructus Schisandrae Chinensis is removed handle, sieve dedust bits, are rolled into cake, are placed in parch container, add rice wine and mix thoroughly, and slow fire stir-fries 5-10 minute (preferred: to stir-fry 8 minutes), takes out;
(Cornu Caprae seu Ovis is rasped to end by 3), and add the Mel submergence of medical material weight 5 times, little fire is endured to its variable color, smashs to pieces after flash baking;
(4) residue medical material is put into pot, the micro-stir-fry of little fire, taking-up cools, and mixes, pulverize and sieve with above-mentioned medical material, according to the processing method of tablet, is pressed into lamellar, is packaged to be tablet.
10. the preparation method of the Chinese medicinal tablet for the treatment of facial spasm as claimed in claim 9, is characterized in that, pulverized 160-190 mesh sieve (preferred: to pulverize 170-180 mesh sieve in step (4); Be more preferably: pulverized 175 mesh sieves).
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Application publication date: 20150422 |