CN104435922A - Traditional Chinese medicine composition for treating arteriosclerosis - Google Patents

Traditional Chinese medicine composition for treating arteriosclerosis Download PDF

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CN104435922A
CN104435922A CN201410791443.7A CN201410791443A CN104435922A CN 104435922 A CN104435922 A CN 104435922A CN 201410791443 A CN201410791443 A CN 201410791443A CN 104435922 A CN104435922 A CN 104435922A
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radix
herba
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caulis
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李建德
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Abstract

The invention discloses a traditional Chinese medicine composition for treating arteriosclerosis. The composition comprises schisandra neglecta, the root of trapa incisa, gynostemma pentaphyllum, barbed skullcap herb, manyprickle acathopanax root, leaf of Chinaroot greenbrier, tuber fleeceflower stem, dog penis, hawthorn fruit, Danshen root, longstamen onion bulb, root of Sinkiang arnebia, wildrice stem, common fenugreek seed, lotus plumule, herb of hispid arthraxon, herb of siebold buttercup, twig and leaf of eriocarpous glochidion, thunbergia fragrans and common andrographis herb. The traditional Chinese medicine composition has the beneficial effects that the composition is specially used for treating arteriosclerosis, is safe to apply clinically and does not irritate internal organs after being taken; through reasonable compatibility of the components, the curative effects are obviously improved, the medicine properties are changed or alleviated, and the toxicity and side effects of the medicines are eliminated; the composition is short in treatment cycle and has obvious curative effects; clinical application studies show that the effective arteriosclerosis cure rate and total effective rate of the composition are respectively 92% and 98%.

Description

One treats arteriosclerotic Chinese medicine composition
Technical field
Technical field of traditional Chinese medicine of the present invention, particularly one treats arteriosclerotic Chinese medicine composition.
Background technology
Cerebral arteriosclerosis is more common in the male of more than 40 years old and the women in menopause, main change is steatosis and the cholesterol deposits of endarterium deep layer, form atherosclerotic plaque and various secondary affection, make tube chamber spasm, narrow, even inaccessible, then cause a series of neuropsychiatric disorders.May be closely related with factors such as age, hypertension, hyperlipidemia, diabetes, obesities, it is multifactor, the interactional complex process of too many levels, wherein vascular endothelial injury, vascular smooth muscle cell curing, blood lipid level too high or metabolism disorder, platelet activation, gathering etc. play an important role in arteriosclerosis evolution, but its exact cause is not yet illustrated.Thus bring certain difficulty to treatment, what specific medicament is doctor trained in Western medicine there is no, and just give blood fat reducing for symptom, expand blood vessel, improve brain blood circulation, improve the treatments such as brain metabolism, uncertain therapeutic efficacy is fixed, and easily recurs.Cerebral arteriosclerosis belongs to the dizzy category of motherland's medical science, due to people in middle age, Liver and kidney is mainly with loss, in addition large, the long-term psychentonia of operating pressure, stay up late, daily life accidentally or innate deficiency, cause Liver and kidney more empty exhausted, wind from interior life, the horizontal gram spleen soil of wind wood, insufficiency of the spleenly lose in building fortune, then water retention is wet, wet consor expectorant, and with the passing of time the stagnation of phlegm stasis of blood is raw, hoodwink key and falling ill clearly, so treatment primary disease, the characteristic of traditional Chinese medical science organic conception, treatment must aim at the pathogenesis of disease should be developed, adopt the method for nourishing liver and kidney, function of spleen and stomach regulating, blood circulation promoting and blood stasis dispelling, clearing away phlegm refreshment.
Arteriosclerosis is very big to body harm, has a strong impact on the daily life of patient, adopts Chinese traditional treatment arteriosclerosis to be widely accepted at present.
The Chinese invention patent that application publication number is " CN 102935178 A " discloses a kind of Chinese medicine for the treatment of cerebral arteriosclerosis, is that raw material is made by fructus lycii, Fructus Corni, Herba Dendrobii, Radix Angelicae Sinensis, Rhizoma Gastrodiae, Radix Polygoni Multiflori Preparata, Radix Achyranthis Bidentatae, Rhizoma Atractylodis Macrocephalae, Radix Salviae Miltiorrhizae, Fructus Crataegi (parched to brown), stir-fry BUZI, the Rhizoma Pinelliae, Exocarpium Citri Rubrum, Poria, Radix Notoginseng, Radix Polygalae (parched).This Chinese medicine composition is about 95.4% to arteriosclerotic total effective rate, but it is only about 31.7% to arteriosclerosis cure rate, and cure rate is low.
Summary of the invention
For making up above deficiency, the invention provides a kind of evident in efficacy, safe and reliable, taking convenience and the high treatment season arteriosclerotic Chinese medicine composition of cure rate.
The technical solution used in the present invention is:
One treats arteriosclerotic Chinese medicine composition, according to weight parts, composed of the following components: Yunnan five tastes 12-30 part, wild Pedicellus et Pericarpium Trapae root 15-25 part, Herb Gynostemmae Pentaphylli 10-20 part, Herba Scutellariae Barbatae 10-20 part, Radix Et Caulis Acanthopanacis Senticosi 10-20 part, Folium smilacis chinensis 10-20 part, Caulis Polygoni Multiflori 10-20 part, Testis et Pentis Canis 10-20 part, Fructus Crataegi 10-20 part, Radix Salviae Miltiorrhizae 5-12 part, Bulbus Allii Macrostemonis 5-12 part, Radix Arnebiae (Radix Lithospermi) 5-12 part, Caulis Zizaniae caduciflorae 5-12 part, Semen Trigonellae 5-12 part, Plumula Nelumbinis 5-20 part, Herba Arthraxonis Hispidi 10-20 part, Folium rhoeinis 10-20 part, Radix Glochidionis eriocarpi 10-20 part, Thunbergia fragrans Roxb. 20-30 part, HERBA ANDROGRAPHITID 10-20 part.
Preferably, according to weight parts, composed of the following components: Yunnan five tastes 15-25 part, wild Pedicellus et Pericarpium Trapae root 18-22 part, Herb Gynostemmae Pentaphylli 13-18 part, Herba Scutellariae Barbatae 13-18 part, Radix Et Caulis Acanthopanacis Senticosi 13-18 part, Folium smilacis chinensis 13-18 part, Caulis Polygoni Multiflori 13-18 part, Testis et Pentis Canis 13-18 part, Fructus Crataegi 13-18 part, Radix Salviae Miltiorrhizae 8-10 part, Bulbus Allii Macrostemonis 8-10 part, Radix Arnebiae (Radix Lithospermi) 8-10 part, Caulis Zizaniae caduciflorae 8-10 part, Semen Trigonellae 8-10 part, Plumula Nelumbinis 10-18 part, Herba Arthraxonis Hispidi 15-17 part, Folium rhoeinis 15-17 part, Radix Glochidionis eriocarpi 15-17 part, Thunbergia fragrans Roxb. 22-27 part, HERBA ANDROGRAPHITID 15-17 part.
Further, according to weight parts, composed of the following components: the Yunnan five tastes 21 parts, wild Pedicellus et Pericarpium Trapae root 20 parts, Herb Gynostemmae Pentaphylli 15 parts, Herba Scutellariae Barbatae 15 parts, Radix Et Caulis Acanthopanacis Senticosi 15 parts, Folium smilacis chinensis 15 parts, Caulis Polygoni Multiflori 15 parts, Testis et Pentis Canis 15 parts, Fructus Crataegi 15 parts, Radix Salviae Miltiorrhizae 9 parts, Bulbus Allii Macrostemonis 9 parts, Radix Arnebiae (Radix Lithospermi) 9 parts, Caulis Zizaniae caduciflorae 9 parts, Semen Trigonellae 9 parts, Plumula Nelumbinis 12 parts, Herba Arthraxonis Hispidi 15 parts, Folium rhoeinis 15 parts, Radix Glochidionis eriocarpi 15 parts, Thunbergia fragrans Roxb. 25 parts, HERBA ANDROGRAPHITID 15 parts.
The Yunnan five tastes, sour in the mouth, sweet, warm in nature; Return lung, the heart, kidney channel, restrain astringent or styptic treatment for spontaneous sweating; Supplementing QI for promoting the production of body fluid; Kidney calming; Main chronic cough dyspnea due to deficiency; Emission; Enuresis frequent micturition; Incessant chronic diarrhea; Spontaneous perspiration; Night sweat; Tianjin wound is thirsty; To lose heart deficient pulse; Interior-heat is quenched one's thirst; Palpitation and insomnia;
Wild Pedicellus et Pericarpium Trapae root, mildly bitter flavor, cool in nature; Relieving stranguria by diuresis, main urine leaching pain;
Herb Gynostemmae Pentaphylli, bitter in the mouth, cold in nature; Heat-clearing and toxic substances removing, eliminating phlegm and stopping cough; For chronic bronchitis, infectious hepatitis, nephritis, gastroenteritis;
Herba Scutellariae Barbatae, acrid in the mouth, hardship, cold in nature; Return lung, liver, kidney channel; Heat-clearing and toxic substances removing, blood stasis dispelling diuresis; For furuncle swelling toxin, laryngopharynx swelling and pain, venom, falls and flutters the pain of injury, edema, jaundice;
Radix Et Caulis Acanthopanacis Senticosi, acrid in the mouth, micro-hardship, warm in nature, return spleen, kidney, heart channel; Replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization; For deficiency of spleen-YANG and kidneyYANG, body void is weak, inappetence, soreness of waist and knee joint, insomnia and dreamful sleep;
Folium smilacis chinensis, sweet in the mouth, property is put down, and dispels the wind; Dampness removing; Removing toxic substances; Main air swells; Furuncle; Toxic swelling; Ecthyma; Burn and scald;
Caulis Polygoni Multiflori, sweet in the mouth is put down, and enters the heart, Liver Channel; Nourish heart, calm the nerves, dredging collateral, dispel the wind; Control insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies;
Testis et Pentis Canis, salty in the mouth, hot greatly, warming the kidney, tonifying YANG, benefit essence; For impotence due to deficiency of the kidney, seminal emission, soreness of the waist and knees;
Fructus Crataegi, sour in the mouth, sweet, slightly warm in nature, returns spleen, stomach, Liver Channel; Promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis; For meat stagnation, gastral cavilty distension, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia; The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens; For meat stagnation, dysentery is not well
Radix Salviae Miltiorrhizae, bitter in the mouth, cold nature; GUIXIN, Liver Channel; Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the relieving restlessness that clears away heart-fire for menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris;
Bulbus Allii Macrostemonis, acrid in the mouth, hardship, warm in nature; Return lung, stomach, large intestine channel; Activating YANG and eliminating stagnation, circulation of qi promoting intestinal stasis relieving; For thoracic obstruction pain, phlegm retention cough with asthma is heavy after letting out dysentery;
Radix Arnebiae (Radix Lithospermi), sweet in the mouth, cold in nature, GUIXIN, Liver Channel; Removing heat from blood, invigorates blood circulation, removing toxic substances rash; Heat in blood poison is contained, and macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire;
Caulis Zizaniae caduciflorae, sweet in the mouth, cold in nature; Enter liver, spleen two warp; Relieving heat toxin, relieving thirst and restlessness, profit two just controls dysphoria with smothery sensation, quenches one's thirst, jaundice, dysentery, conjunctival congestion, wind skin ulcer;
Semen Trigonellae, bitter in the mouth, warm in nature; Return kidney channel; The kidney warming, cold relieving, pain relieving; For kidney cold caused by deficiency, cold and pain in the lower abdomen, inguinal hernia, the disturbance of lower legs due to pathogenic cold and dampness;
Plumula Nelumbinis, bitter in the mouth, cold in nature; GUIXIN, kidney channel; Clearing away heart-fire for tranquillization, restoring normal coordination between the heart and kidney, unsmoothing the sperm and stopping bleeding; For heat attacking the pericardium, unconsciousness and delirium, disarmony between the heart and kidney, insomnia seminal emission, heat in blood is spitted blood;
Herba Arthraxonis Hispidi, bitter in the mouth, property is put down; Cough-relieving, Dingchuan, parasite killing; " herbal classic " is recorded: " main chronic cough dyspnea due to adverse flow of lung-QI is inverse, trembles with fear for a long time, palpitation with fear, crusted scabies, and white bald infections gas, kills skin small worm ";
Folium rhoeinis, sweet-bitter flavor, cool in nature; Heat clearing away, hemostasis, blood stasis removing controls lung-heat type cough, spits blood, has blood in stool, hematuria, dysentery, traumatic injury;
Radix Glochidionis eriocarpi, bitter in the mouth, puckery, property is put down; Return large intestine channel; Heat-clearing and toxic substances removing; Removing dampness to relieve itching; Main intestinal is scorching; Dysentery; Toothache; Throat pain; Mastitis; Skin eczema; Burn; Leucorrhea;
Thunbergia fragrans Roxb., acrid in the mouth, the micro-acid of property; Invigorating the stomach and promoting digestion; Removing toxic substances and promoting subsidence of swelling; Main dyspepsia; Abdominal distention; Diarrhoea; Carbuncle furuncle;
HERBA ANDROGRAPHITID, bitter in the mouth, cold in nature, heat-clearing and toxic substances removing.
Using method: traditionally Traditional Chinese medicine decocting method, makes decoction with decocting, daily 2-4 time, and 15 days is a course for the treatment of.
Taboo: anemia of pregnant woman is forbidden; Quit smoking during medication, wine, rareripe, raw Bulbus Allii, pungent irritable food and greasy food.
Beneficial effect of the present invention is:
Chinese medicine composition of the present invention, is exclusively used in arteriosclerosis, and clinical practice safety, takes and do not stimulate internal organs.Significantly improve curative effect by the reasonable compatibility of each component, change or relaxed the property of medicine, eliminating the Side effect of medicine.Treatment cycle is short and evident in efficacy, and clinical application research shows, the present invention reaches 92% to arteriosclerotic effective cure rate, and total effective rate reaches 98%.
Detailed description of the invention
Embodiment 1
One treats arteriosclerotic Chinese medicine composition, composed of the following components: Yunnan five tastes 21g, wild Pedicellus et Pericarpium Trapae root 20g, Herb Gynostemmae Pentaphylli 15g, Herba Scutellariae Barbatae 15g, Radix Et Caulis Acanthopanacis Senticosi 15g, Folium smilacis chinensis 15g, Caulis Polygoni Multiflori 15g, Testis et Pentis Canis 15g, Fructus Crataegi 15g, Radix Salviae Miltiorrhizae 9g, Bulbus Allii Macrostemonis 9g, Radix Arnebiae (Radix Lithospermi) 9g, Caulis Zizaniae caduciflorae 9g, Semen Trigonellae 9g, Plumula Nelumbinis 12g, Herba Arthraxonis Hispidi 15g, Folium rhoeinis 15g, Radix Glochidionis eriocarpi 15g, Thunbergia fragrans Roxb. 25g, HERBA ANDROGRAPHITID 15g.
Traditionally Traditional Chinese medicine decocting method, makes decoction with decocting, and 2-4 agent every day is taken orally, within 15 days, is a course for the treatment of.
Embodiment 2
One treats arteriosclerotic Chinese medicine composition, composed of the following components: Yunnan five tastes 15g, wild Pedicellus et Pericarpium Trapae root 18g, Herb Gynostemmae Pentaphylli 13g, Herba Scutellariae Barbatae 13g, Radix Et Caulis Acanthopanacis Senticosi 13g, Folium smilacis chinensis 18g, Caulis Polygoni Multiflori 18g, Testis et Pentis Canis 18g, Fructus Crataegi 18g, Radix Salviae Miltiorrhizae 10g, Bulbus Allii Macrostemonis 8g, Radix Arnebiae (Radix Lithospermi) 8g, Caulis Zizaniae caduciflorae 8g, Semen Trigonellae 8g, Plumula Nelumbinis 10g, Herba Arthraxonis Hispidi 17g, Folium rhoeinis 17g, Radix Glochidionis eriocarpi 17g, Thunbergia fragrans Roxb. 27g, HERBA ANDROGRAPHITID 17g.
Traditionally Traditional Chinese medicine decocting method, makes decoction with decocting, and 2-4 agent every day is taken orally, within 15 days, is a course for the treatment of.
Embodiment 3
One treats arteriosclerotic Chinese medicine composition, composed of the following components: Yunnan five tastes 25g, wild Pedicellus et Pericarpium Trapae root 22g, Herb Gynostemmae Pentaphylli 18g, Herba Scutellariae Barbatae 18g, Radix Et Caulis Acanthopanacis Senticosi 18g, Folium smilacis chinensis 13g, Caulis Polygoni Multiflori 13g, Testis et Pentis Canis 13g, Fructus Crataegi 13g, Radix Salviae Miltiorrhizae 8g, Bulbus Allii Macrostemonis 10g, Radix Arnebiae (Radix Lithospermi) 10g, Caulis Zizaniae caduciflorae 10g, Semen Trigonellae 10g, Plumula Nelumbinis 18g, Herba Arthraxonis Hispidi 15g, Folium rhoeinis 15g, Radix Glochidionis eriocarpi 15g, Thunbergia fragrans Roxb. 22g, HERBA ANDROGRAPHITID 15g.
Traditionally Traditional Chinese medicine decocting method, makes decoction with decocting, and 2-4 agent every day is taken orally, within 15 days, is a course for the treatment of.
Embodiment 4
One treats arteriosclerotic Chinese medicine composition, composed of the following components: Yunnan five tastes 22g, wild Pedicellus et Pericarpium Trapae root 20g, Herb Gynostemmae Pentaphylli 15g, Herba Scutellariae Barbatae 15g, Radix Et Caulis Acanthopanacis Senticosi 15g, Folium smilacis chinensis 17g, Caulis Polygoni Multiflori 17g, Testis et Pentis Canis 17g, Fructus Crataegi 17g, Radix Salviae Miltiorrhizae 8g, Bulbus Allii Macrostemonis 8g, Radix Arnebiae (Radix Lithospermi) 8g, Caulis Zizaniae caduciflorae 10g, Semen Trigonellae 10g, Plumula Nelumbinis 16g, Herba Arthraxonis Hispidi 16g, Folium rhoeinis 16g, Radix Glochidionis eriocarpi 16g, Thunbergia fragrans Roxb. 24g, HERBA ANDROGRAPHITID 16g.
Traditionally Traditional Chinese medicine decocting method, makes decoction with decocting, and 2-4 agent every day is taken orally, within 15 days, is a course for the treatment of.
Embodiment 5
One treats arteriosclerotic Chinese medicine composition, composed of the following components: Yunnan five tastes 12g, wild Pedicellus et Pericarpium Trapae root 15g, Herb Gynostemmae Pentaphylli 10g, Herba Scutellariae Barbatae 10g, Radix Et Caulis Acanthopanacis Senticosi 10g, Folium smilacis chinensis 20g, Caulis Polygoni Multiflori 20g, Testis et Pentis Canis 20g, Fructus Crataegi 20g, Radix Salviae Miltiorrhizae 12g, Bulbus Allii Macrostemonis 5g, Radix Arnebiae (Radix Lithospermi) 5g, Caulis Zizaniae caduciflorae 5g, Semen Trigonellae 5g, Plumula Nelumbinis 5g, Herba Arthraxonis Hispidi 10g, Folium rhoeinis 20g, Radix Glochidionis eriocarpi 20g, Thunbergia fragrans Roxb. 30g, HERBA ANDROGRAPHITID 20g.
Traditionally Traditional Chinese medicine decocting method, makes decoction with decocting, and 2-4 agent every day is taken orally, within 15 days, is a course for the treatment of.
Embodiment 6
One treats arteriosclerotic Chinese medicine composition, composed of the following components: Yunnan five tastes 30g, wild Pedicellus et Pericarpium Trapae root 25g, Herb Gynostemmae Pentaphylli 20g, Herba Scutellariae Barbatae 20g, Radix Et Caulis Acanthopanacis Senticosi 20g, Folium smilacis chinensis 10g, Caulis Polygoni Multiflori 10g, Testis et Pentis Canis 10g, Fructus Crataegi 10g, Radix Salviae Miltiorrhizae 5g, Bulbus Allii Macrostemonis 5g, Radix Arnebiae (Radix Lithospermi) 12g, Caulis Zizaniae caduciflorae 12g, Semen Trigonellae 12g, Plumula Nelumbinis 20g, Herba Arthraxonis Hispidi 20g, Folium rhoeinis 10g, Radix Glochidionis eriocarpi 10g, Thunbergia fragrans Roxb. 20g, HERBA ANDROGRAPHITID 10g.
Traditionally Traditional Chinese medicine decocting method, makes decoction with decocting, and 2-4 agent every day is taken orally, within 15 days, is a course for the treatment of.
Embodiment 7
One treats arteriosclerotic Chinese medicine composition, composed of the following components: Yunnan five tastes 27g, wild Pedicellus et Pericarpium Trapae root 22g, Herb Gynostemmae Pentaphylli 11g, Herba Scutellariae Barbatae 11g, Radix Et Caulis Acanthopanacis Senticosi 13g, Folium smilacis chinensis 13g, Caulis Polygoni Multiflori 11g, Testis et Pentis Canis 11g, Fructus Crataegi 11g, Radix Salviae Miltiorrhizae 8g, Bulbus Allii Macrostemonis 8g, Radix Arnebiae (Radix Lithospermi) 8g, Caulis Zizaniae caduciflorae 8g, Semen Trigonellae 8g, Plumula Nelumbinis 20g, Herba Arthraxonis Hispidi 15g, Folium rhoeinis 17g, Radix Glochidionis eriocarpi 17g, Thunbergia fragrans Roxb. 26g, HERBA ANDROGRAPHITID 13g.
Traditionally Traditional Chinese medicine decocting method, makes decoction with decocting, and 2-4 agent every day is taken orally, within 15 days, is a course for the treatment of.
Embodiment 8
One treats arteriosclerotic Chinese medicine composition, composed of the following components: Yunnan five tastes 18g, wild Pedicellus et Pericarpium Trapae root 22g, Herb Gynostemmae Pentaphylli 15g, Herba Scutellariae Barbatae 13g, Radix Et Caulis Acanthopanacis Senticosi 13g, Folium smilacis chinensis 13g, Caulis Polygoni Multiflori 13g, Testis et Pentis Canis 11g, Fructus Crataegi 11g, Radix Salviae Miltiorrhizae 12g, Bulbus Allii Macrostemonis 12g, Radix Arnebiae (Radix Lithospermi) 7g, Caulis Zizaniae caduciflorae 12g, Semen Trigonellae 12g, Plumula Nelumbinis 13g, Herba Arthraxonis Hispidi 13g, Folium rhoeinis 13g, Radix Glochidionis eriocarpi 13g, Thunbergia fragrans Roxb. 22g, HERBA ANDROGRAPHITID 18g.
Traditionally Traditional Chinese medicine decocting method, makes decoction with decocting, and 2-4 agent every day is taken orally, within 15 days, is a course for the treatment of.
Clinical observation
Physical data
The present inventor carried out clinical observation treatment to 500 routine arteriosclerotics so far in 2011,20 to 75 years old ages, and the course of disease 1 ~ 10 year is not etc.
Therapeutic Method: for oral administration, every day 2-4 time, each potion, dose described in every agent and each embodiment 15 days is a course for the treatment of.
Efficacy assessment standard
Efficacy assessment standard is formulated with reference to " Chinese medicine Clinical Researches of New Drugs guideline ":
" healing ": Clinical symptom and sign disappears;
Basic or the major part of " effective " Clinical symptom and sign disappears;
" effectively:, Clinical symptom and sign has and alleviates or alleviate;
Engineering noise Clinical symptom and sign is without improvement.
Therapeutic effect
Clinical cure accounts for 92%, effectively accounts for 4.1%, effectively accounts for 1.9%, invalidly accounts for 2%, and total effective rate reaches 98%.
Model case:
1. Huang, man, 59 years old, patient, dizzy, headache, nape pain, two weakness of the lower extremities more than 2 years, heavy time light during symptom, during severe symptoms dizziness and tinnitus can not get up, dynamic then nausea and vomiting, measuring blood pressure 130/80mmHg, blood fat is normal.TCD shows: the two vertebral artery of middle cerebral artery speeds, end stream noise.Diagnosis: cerebral vasospasm; Taking the made Chinese medicine composition of the embodiment of the present invention 1, every day three doses, 15 days is a course for the treatment of, 3 the course for the treatment of symptom be clearly better, then to cure after consolidating 2 courses for the treatment of; This condition subject i.e., cures after using 5 courses for the treatment of of Chinese medicine composition of the present invention, follows up a case by regular visits to without recurrence after 1 year.
2. Wang, man, 42 years old, unknown cause was dizzy, dizzy heavy, hypomnesis, insomnia, measuring blood pressure 130/90mmHg, blood fat is slightly high, TCD checks: two brain and posterior cerebral artery blood flow rate symmetrical, flow velocity is slow, and bilateral vertebral artery blood flow rate is left-right asymmetry, and left side flow velocity is slow.Diagnosis: 1. cerebral arteriosclerosis, use the made Chinese medicine composition of the embodiment of the present invention 2, every day three doses, within 15 days, be a course for the treatment of, namely take effect less than 2 courses for the treatment of, after 4 courses for the treatment of, symptom disappears substantially, cures after consolidating 1 course for the treatment of; This condition subject i.e., cures after using 5 courses for the treatment of of Chinese medicine composition of the present invention, follows up a case by regular visits to without recurrence after 1 year.

Claims (3)

1. the arteriosclerotic Chinese medicine composition for the treatment of, it is characterized in that, according to weight parts, composed of the following components: Yunnan five tastes 12-30 part, wild Pedicellus et Pericarpium Trapae root 15-25 part, Herb Gynostemmae Pentaphylli 10-20 part, Herba Scutellariae Barbatae 10-20 part, Radix Et Caulis Acanthopanacis Senticosi 10-20 part, Folium smilacis chinensis 10-20 part, Caulis Polygoni Multiflori 10-20 part, Testis et Pentis Canis 10-20 part, Fructus Crataegi 10-20 part, Radix Salviae Miltiorrhizae 5-12 part, Bulbus Allii Macrostemonis 5-12 part, Radix Arnebiae (Radix Lithospermi) 5-12 part, Caulis Zizaniae caduciflorae 5-12 part, Semen Trigonellae 5-12 part, Plumula Nelumbinis 5-20 part, Herba Arthraxonis Hispidi 10-20 part, Folium rhoeinis 10-20 part, Radix Glochidionis eriocarpi 10-20 part, Thunbergia fragrans Roxb. 20-30 part, HERBA ANDROGRAPHITID 10-20 part.
2. treat arteriosclerotic Chinese medicine composition as claimed in claim 1, it is characterized in that: according to weight parts, composed of the following components: Yunnan five tastes 15-25 part, wild Pedicellus et Pericarpium Trapae root 18-22 part, Herb Gynostemmae Pentaphylli 13-18 part, Herba Scutellariae Barbatae 13-18 part, Radix Et Caulis Acanthopanacis Senticosi 13-18 part, Folium smilacis chinensis 13-18 part, Caulis Polygoni Multiflori 13-18 part, Testis et Pentis Canis 13-18 part, Fructus Crataegi 13-18 part, Radix Salviae Miltiorrhizae 8-10 part, Bulbus Allii Macrostemonis 8-10 part, Radix Arnebiae (Radix Lithospermi) 8-10 part, Caulis Zizaniae caduciflorae 8-10 part, Semen Trigonellae 8-10 part, Plumula Nelumbinis 10-18 part, Herba Arthraxonis Hispidi 15-17 part, Folium rhoeinis 15-17 part, Radix Glochidionis eriocarpi 15-17 part, Thunbergia fragrans Roxb. 22-27 part, HERBA ANDROGRAPHITID 15-17 part.
3. treat arteriosclerotic Chinese medicine composition as claimed in claim 2, it is characterized in that: according to weight parts, composed of the following components: the Yunnan five tastes 21 parts, wild Pedicellus et Pericarpium Trapae root 20 parts, Herb Gynostemmae Pentaphylli 15 parts, Herba Scutellariae Barbatae 15 parts, Radix Et Caulis Acanthopanacis Senticosi 15 parts, Folium smilacis chinensis 15 parts, Caulis Polygoni Multiflori 15 parts, Testis et Pentis Canis 15 parts, Fructus Crataegi 15 parts, Radix Salviae Miltiorrhizae 9 parts, Bulbus Allii Macrostemonis 9 parts, Radix Arnebiae (Radix Lithospermi) 9 parts, Caulis Zizaniae caduciflorae 9 parts, Semen Trigonellae 9 parts, Plumula Nelumbinis 12 parts, Herba Arthraxonis Hispidi 15 parts, Folium rhoeinis 15 parts, Radix Glochidionis eriocarpi 15 parts, Thunbergia fragrans Roxb. 25 parts, HERBA ANDROGRAPHITID 15 parts.
CN201410791443.7A 2014-12-19 2014-12-19 Traditional Chinese medicine composition for treating arteriosclerosis Pending CN104435922A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105435120A (en) * 2015-12-29 2016-03-30 青岛昌安达药业有限公司 Traditional Chinese medicine decoction for treating arteriosclerosis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1142370A (en) * 1995-08-07 1997-02-12 杨旭义 Capsule for cerebral arteriosclerosis
CN1317331A (en) * 2000-04-08 2001-10-17 昆明制药股份有限公司 Compound Chinese medicinal preparation for treating cerebral arteriosclerosis and production method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1142370A (en) * 1995-08-07 1997-02-12 杨旭义 Capsule for cerebral arteriosclerosis
CN1317331A (en) * 2000-04-08 2001-10-17 昆明制药股份有限公司 Compound Chinese medicinal preparation for treating cerebral arteriosclerosis and production method thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
成绍武等: "中医对动脉粥样硬化的认识及防治研究进展", 《湖南中医药导报》 *
王劲红等: "自拟五味降脂散治疗高脂血症66例分析", 《实用中医内科杂志》 *
程晓昱等: "怡脉颗粒对家兔动脉粥样硬化斑块及MMP-9的影响", 《中西医结合心脑血管病杂志》 *
魏玉香: "《常见脑病的中医治疗与康复》", 31 July 2009, 中国中医药出版社 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105435120A (en) * 2015-12-29 2016-03-30 青岛昌安达药业有限公司 Traditional Chinese medicine decoction for treating arteriosclerosis

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Application publication date: 20150325