CN103394058B - Medicament for treating postpartum disease and preparation method thereof - Google Patents

Medicament for treating postpartum disease and preparation method thereof Download PDF

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CN103394058B
CN103394058B CN201310321396.5A CN201310321396A CN103394058B CN 103394058 B CN103394058 B CN 103394058B CN 201310321396 A CN201310321396 A CN 201310321396A CN 103394058 B CN103394058 B CN 103394058B
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radix
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rhizoma
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肖变化
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肖变化
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Abstract

The invention discloses a medicament for treating a postpartum disease and a preparation method thereof. The medicament is mainly prepared from angelica, szechuan lovage rhizome, prepared rhizome of rehmannia, white paeony root, foreign ginseng and astragalus according to a certain weight ratio. The medicament has the effects of enriching blood, activating blood circulation, regulating menstruation, relieving pain, warming stomach and spleen and removing internal cold, and has quick response, good curative effect and high cure rate when used for treating the postpartum disease.

Description

A kind of medicine for the treatment of puerperal exposure to wind and preparation method thereof
Technical field
The present invention relates to a kind of medicine for the treatment of puerperal exposure to wind and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Puerperal exposure to wind, is named again " puerperal fever ".Be women in production child period, because muscles and bones space between skin and muscles is opened greatly, physical weakness, inside and outside empty not preventing wind-cold pathogen invades.In the convalescent period of " in puerperal period ", muscles and bones space between skin and muscles close close, make wind and cold wrap in body, for it puerperal period puerperal exposure to wind refractory reason.Childbirth at advanced age, difficult labour, cesarean, the puerpera Geng Yi that repeatedly miscarries suffer from puerperal exposure to wind.Generally after 8 weeks puerperal, there is symptom, if let go unchecked, just likely periods of months even several years.At present, because Western medicine effectively cannot treat puerperal exposure to wind, and long-term taking Western medicine has more side effect, and therefore, people exist very large demand to the Chinese medicine of effectively treating puerperal exposure to wind.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment puerperal exposure to wind, thus completes the present invention.
Object of the present invention is just to provide a kind of composition of medicine effectively can treating puerperal exposure to wind.
Another object of the present invention just there is provided the preparation method of this composition of medicine.
Medicine of the present invention selects Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Panacis Quinquefolii, the Radix Astragali, Poria, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Lycopi, Radix Glycyrrhizae medicine to combine, each efficacy of drugs is made by these drug regimens to produce synergism, thus can the recurrence of fast treating puerperal exposure to wind.Wherein select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm, enter the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize the function of laxation, control menoxenia, amenorrhea stomachache , mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood is dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty is just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Select Rhizoma Chuanxiong to be that temperature, enters liver, gallbladder meridian, have activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain, control air-cooled headache and revolve dizzy because its nature and flavor are pungent, hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.Select Radix Rehmanniae Preparata to be that tepor, enters liver, kidney channel, have YIN nourishing, and the function of enriching blood controls deficiency of YIN insufficiency of blood, waist knee flaccidity, chronic cough hectic fever due to YIN-deficiency because its nature and flavor are sweet, seminal emission, metrorrhagia, menoxenia, quenches one's thirst, frequency of micturition, deaf, blurred vision.Select the Radix Paeoniae Alba to be because its nature and flavor picric acid, cool, enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, and dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Radix Panacis Quinquefolii is selected to be that cool, enter the heart, lung, kidney three warp, useful lung yin, clear asthenic fire, the function of promoting the production of body fluid to quench thirst, control deficiency of the lung chronic cough, lose blood, dry throat and mouth, deficiency-heat is tired of tired because its property sweet and slightly bitter taste.Select the Radix Astragali to be that tepor, enters lung, spleen channel because its nature and flavor are sweet, life defends consolidating superficial resistance with useful, inducing diuresis to remove edema, poison holding, and the function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, and carbuncle is not burst or burst and holds back for a long time; Processing the function with there being invigorating middle warmer benefit, controlling internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select Poria to be because its property slightly sweet flavor, flat, enter the heart, spleen, lung meridian, have eliminating dampness and diuresis, strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, control dysuria edema distending pain, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.Select the Rhizoma Atractylodis Macrocephalae to be because its property bitter but sweet flavor, temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizzy, spontaneous perspiration, and nausea is uneasy.Select Cortex Cinnamomi to be because its property acrid-sweet flavor, heat, enters kidney, spleen, urinary bladder channel, has complement sun, warming the spleen and stomach, removing accumulated cold, the function of promoting blood circulation, controls decline of the fire from the gate of life, cold extremities faint pulse, and YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea and mass in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.Radix Aconiti Lateralis Preparata is selected to be because its property acrid-sweet flavor, heat, poisonous, enter the heart, spleen, kidney channel, have recuperating depleted YANG to mend fire, the function of dispelling cold and removing dampness, control excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhea is fainted inverse, trusted subordinate's cold type of pain, the splenic diarrhea cold-dysentery, beriberi edema, children's's intermittent infantile convulsion, the contracture of anemofrigid-damp arthralgia , Wei lame, the disease of the leakage of carbuncle of yin nature skin ulcer and all chronic diseaseses.Select Rhizoma Zingiberis Recens to be because its nature and flavor are pungent, temperature, enter lung, stomach, spleen channel, deliver, cold expelling, preventing or arresting vomiting, open the function of expectorant, cure cold wind and cold, vomiting, and phlegm retention, breathes with cough, and distension is had loose bowels, and separates the Rhizoma Pinelliae, Rhizoma Arisaematis and fish Eriocheir sinensis, birds and beasts meat poisoning.Fructus Schisandrae Chinensis is selected to be that temperature, enters lung, kidney channel, astringe the lung, nourishing kidney, promote the production of body fluid, and receive antiperspirant, the function of arresting seminal emission, controls the deficiency of the lung and breath with cough, and xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery because its nature and flavor acid; Herba Lycopi is selected to be that tepor, enters liver, spleen channel, invigorate blood circulation, the function of row water, controls amenorrhea , mass in the abdomen, the stagnant stomachache of the stasis of blood in puerperal, body and face edema, injury from falling down, incised wound, carbuncle because its nature and flavor toil.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.
Detailed description of the invention
The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Radix Angelicae Sinensis 10-20 grams of Rhizoma Chuanxiongs 10-20 grams of Radix Rehmanniae Preparata 10-20 grams
The Radix Paeoniae Alba 10-20 grams of Radix Panacis Quinquefoliis 10-20 grams of Radixs Astragali 10-20 grams
Poria 10-20 grams of Rhizoma Atractylodis Macrocephalaes 10-20 grams of Cortex Cinnamomis 8-15 grams
Radix Aconiti Lateralis Preparata 8-15 grams of Rhizoma Zingiberis Recenss 8-15 grams of Fructus Schisandrae Chinensis 8-15 grams
8-15 grams, Herba Lycopi 8-15 grams of Radix Glycyrrhizaes
Preferable amount is
Radix Angelicae Sinensis 15 grams of Rhizoma Chuanxiongs 15 grams of Radix Rehmanniae Preparata 15 grams
The Radix Paeoniae Alba 15 grams of Radix Panacis Quinquefoliis 15 grams of Radixs Astragali 15 grams
Poria 15 grams of Rhizoma Atractylodis Macrocephalaes 15 grams of Cortex Cinnamomis 10 grams
Radix Aconiti Lateralis Preparata 10 grams of Rhizoma Zingiberis Recenss 10 grams of Fructus Schisandrae Chinensis 10 grams
10 grams, Herba Lycopi 10 grams of Radix Glycyrrhizaes
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Radix Angelicae Sinensis: pick decontamination, clean, run through, section is dried;
2, Rhizoma Chuanxiong: pick decontamination, separately large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;
3, Radix Rehmanniae Preparata: get crude drug, steams to surperficial corvinus, takes out, when shining dry to eighty per cant, and section, dry;
4, the Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, section, dry;
5, Radix Panacis Quinquefolii: former medicinal clear water spray tide, cover wet cloth, Xia Qiu moistens 2 days, and Winter-Spring moistens 3 days, takes out section, dries;
6, the Radix Astragali: pick clean impurity, the root head that removing is residual and hollow the greater, be soaked in water;
7, Poria: be soaked in water, cleans and pulls out, and after vexed, section, dries;
8, the Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
9, Cortex Cinnamomi: pick clean impurity, scrape off rough bark, the used time smashes, or scrapes off rough bark, infiltrates a moment by warm water, and section, dries;
10, Radix Aconiti Lateralis Preparata: get Radix Aconiti Lateralis Preparata and clean, clear water soaks a night, except peeling umbilicus, section, add blister to mouth again and taste slightly spicy sense for degree, take out, with ginger decoction leaching 1-3 days, then cook, roast to seventy percent dry again, pour in pot urgent stir-fry of useing force into and rise to cigarette, micro-drum splits for degree, and taking-up cools;
11, Rhizoma Zingiberis Recens: pick decontamination, cleans earth, and the used time cuts into slices;
12, Fructus Schisandrae Chinensis: sieve dedust bits, removing impurity, put in food steamer and steam thoroughly, taking-up is dried;
13, Herba Lycopi: pick decontamination, removing undesirable root, water spray slightly moistens, and cutting is dried;
14, Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing.
Two, prepare
1, the Radix Angelicae Sinensis of described weight, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Panacis Quinquefolii, the Radix Astragali, Poria, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Lycopi, Radix Glycyrrhizae medicine are added 6 times of water gagings, soak after 180 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 25 minutes, filter first time decoction liquor.
2, add water the medicinal residues of filtration 4 times amount, and intense fire decocts boiling 15 minutes, then uses slow fire boiling 15 minutes, filters to obtain second time decoction liquor.
3, twice decoction liquor is merged, then simmer in water 15 minutes, be divided into 3 doses to take decoction medicinal liquid.
Medicine of the present invention has benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, dispeiling pathogenic wind and removing dampness, complement sun, warming the spleen and stomach, effect of removing accumulated cold, and treatment puerperal exposure to wind instant effect, short treating period, do not recur.
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get rabbit 40, male and female dual-purpose, body weight 2.0-2.3kg, divide two groups, often organize 20, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, and every day, secondary, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] medicine of the present invention
1, physical data
Accept out-patient 220 example for medical treatment.
2, diagnostic criteria
Clinical manifestation
General joint, hands, foot, waist, shoulder, sole has ache, numb, is afraid of cold, eyes are uncomfortable, aversion to wind, shed tears, menoxenia, the group of being with, is with black, is with white phenomenon, lower abdomen meeting flatulence, air-blowing, the sensation of micro-pain, face is partially yellow, memory, the phenomenons such as and sexual life obviously declines, diet is not good, and defecation is abnormal.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, each serving with 1 dose, every day is early, middle and late respectively takes 1 time, within 7 days, is a course for the treatment of, takes 5 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: puerperal exposure to wind is eliminated, without recurring after observing half a year;
Take a turn for the better: puerperal exposure to wind symptom is clearly better;
Invalid: symptom, without improvement, does not reach improvement standard person.
5, therapeutic outcome
In above-mentioned treatment, by Drug therapy puerperal exposure to wind patient 220 example of the present invention, effective 212 examples of result, obvious effective rate is 96.36%, and take a turn for the better 5 examples, and improvement rate is 2.27%, and invalid 3 examples, total effective rate is 98.63%.

Claims (3)

1. treat a medicine for puerperal exposure to wind, it is characterized in that: it is made up of the crude drug in following weight range:
Radix Angelicae Sinensis 10-20 grams of Rhizoma Chuanxiongs 10-20 grams of Radix Rehmanniae Preparata 10-20 grams
The Radix Paeoniae Alba 10-20 grams of Radix Panacis Quinquefoliis 10-20 grams of Radixs Astragali 10-20 grams
Poria 10-20 grams of Rhizoma Atractylodis Macrocephalaes 10-20 grams of Cortex Cinnamomis 8-15 grams
Radix Aconiti Lateralis Preparata 8-15 grams of Rhizoma Zingiberis Recenss 8-15 grams of Fructus Schisandrae Chinensis 8-15 grams
8-15 grams, Herba Lycopi 8-15 grams of Radix Glycyrrhizaes.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Radix Angelicae Sinensis 15 grams of Rhizoma Chuanxiongs 15 grams of Radix Rehmanniae Preparata 15 grams
The Radix Paeoniae Alba 15 grams of Radix Panacis Quinquefoliis 15 grams of Radixs Astragali 15 grams
Poria 15 grams of Rhizoma Atractylodis Macrocephalaes 15 grams of Cortex Cinnamomis 10 grams
Radix Aconiti Lateralis Preparata 10 grams of Rhizoma Zingiberis Recenss 10 grams of Fructus Schisandrae Chinensis 10 grams
10 grams, Herba Lycopi 10 grams of Radix Glycyrrhizaes.
3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:
(1) get the raw materials ready
(1) Radix Angelicae Sinensis: pick decontamination, clean, run through, section is dried;
(2) Rhizoma Chuanxiong: pick decontamination, separately large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;
(3) Radix Rehmanniae Preparata: get crude drug, steams to surperficial corvinus, takes out, when shining dry to eighty per cant, and section, dry;
(4) Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, section, dry;
(5) Radix Panacis Quinquefolii: former medicinal clear water spray tide, cover wet cloth, Xia Qiu moistens 2 days, and Winter-Spring moistens 3 days, takes out section, dries;
(6) Radix Astragali: pick clean impurity, the root head that removing is residual and hollow the greater, be soaked in water;
(7) Poria: be soaked in water, cleans and pulls out, and after vexed, section, dries;
(8) Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
(9) Cortex Cinnamomi: pick clean impurity, scrape off rough bark, the used time smashes, or scrapes off rough bark, infiltrates a moment by warm water, and section, dries;
(10) Radix Aconiti Lateralis Preparata: get Radix Aconiti Lateralis Preparata and clean, clear water soaks a night, except peeling umbilicus, section, add blister to mouth again and taste slightly spicy sense for degree, take out, with ginger decoction leaching 1-3 days, then cook, roast to seventy percent dry again, pour in pot urgent stir-fry of useing force into and rise to cigarette, micro-drum splits for degree, and taking-up cools;
(11) Rhizoma Zingiberis Recens: pick decontamination, cleans earth, and the used time cuts into slices;
(12) Fructus Schisandrae Chinensis: sieve dedust bits, removing impurity, put in food steamer and steam thoroughly, taking-up is dried;
(13) Herba Lycopi: pick decontamination, removing undesirable root, water spray slightly moistens, and cutting is dried;
(14) Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing;
(2) prepare
(1) Radix Angelicae Sinensis of described weight, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Panacis Quinquefolii, the Radix Astragali, Poria, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Lycopi, Radix Glycyrrhizae medicine are added 6 times of water gagings, soak after 180 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 25 minutes, filter first time decoction liquor;
(2) add water the medicinal residues of filtration 4 times amount, and intense fire decocts boiling 15 minutes, then uses slow fire boiling 15 minutes, filters to obtain second time decoction liquor;
(3) twice decoction liquor is merged, then simmer in water 15 minutes, be divided into 3 doses to take decoction medicinal liquid.
CN201310321396.5A 2013-07-29 2013-07-29 Medicament for treating postpartum disease and preparation method thereof Expired - Fee Related CN103394058B (en)

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Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104826079A (en) * 2015-05-30 2015-08-12 路云香 Traditional Chinese medicine for treating parturient paresis
CN104940893A (en) * 2015-07-30 2015-09-30 华菊 Medicine for treating puerperal fever and preparation method thereof
CN105535278A (en) * 2016-01-28 2016-05-04 李方 Traditional Chinese medicine capsules used for postpartum care of pregnant women
CN105998314A (en) * 2016-05-31 2016-10-12 罗丁华 Traditional Chinese medicine for treating postpartum pantalgia and preparation method of traditional Chinese medicine
CN106492090A (en) * 2016-12-28 2017-03-15 王于法 A kind of medicine for treating post-abortion general pain and preparation method thereof

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CN1285207A (en) * 2000-09-10 2001-02-28 郝富勤 Medicine specially for treating postpartum disease and cold syndrome
CN101095927A (en) * 2007-07-10 2008-01-02 张忠民 Medicine for treating rheumatism or postpartum rheumatism
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