CN103394058A

CN103394058A - Medicament for treating postpartum disease and preparation method thereof

Info

Publication number: CN103394058A
Application number: CN2013103213965A
Authority: CN
Inventors: 肖变化
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-07-29
Filing date: 2013-07-29
Publication date: 2013-11-20
Anticipated expiration: 2033-07-29
Also published as: CN103394058B

Abstract

The invention discloses a medicament for treating a postpartum disease and a preparation method thereof. The medicament is mainly prepared from angelica, szechuan lovage rhizome, prepared rhizome of rehmannia, white paeony root, foreign ginseng and astragalus according to a certain weight ratio. The medicament has the effects of enriching blood, activating blood circulation, regulating menstruation, relieving pain, warming stomach and spleen and removing internal cold, and has quick response, good curative effect and high cure rate when used for treating the postpartum disease.

Description

A kind of medicine for the treatment of puerperal exposure to wind and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of puerperal exposure to wind and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Puerperal exposure to wind, be again " puerperal fever ".The women producing child's period, because the muscles and bones space between skin and muscles is opened greatly, physical weakness, inside and outside empty not preventing wind-cold pathogen is invaded.In the convalescent period of " in puerperal period ", the muscles and bones space between skin and muscles closes and closes, and wind and cold is wrapped in body, for it puerperal period the puerperal exposure to wind refractory reason.The puerpera Geng Yi of childbirth at advanced age, difficult labour, cesarean, repeatedly miscarriage suffers from puerperal exposure to wind.Generally after 8 weeks of puerperal, symptom occurs, if let go unchecked, just likely continue several years even several months.At present, because Western medicine can't effectively be treated puerperal exposure to wind, and the long-term taking Western medicine has more side effect, and therefore, there is very large demand in people to the Chinese medicine of effective treatment puerperal exposure to wind.

Summary of the invention

The inventor, according to the research of theory of Chinese medical science and clinical repeatedly test and checking, has finally found the medicine of effective treatment puerperal exposure to wind, thereby has completed the present invention.

Purpose of the present invention just is to provide a kind of composition of medicine that can effectively treat puerperal exposure to wind.

Another object of the present invention just has been to provide the preparation method of this composition of medicine.

Medicine of the present invention selects Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Panacis Quinquefolii, the Radix Astragali, Poria, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Lycopi, Radix Glycyrrhizae medicine to make up, make each efficacy of drugs produce synergism these drug regimens, thus recurrence that can the fast treating puerperal exposure to wind.Wherein select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm enters the heart, liver, spleen channel, benefiting blood and regulating blood circulation is arranged, menstruction regulating and pain relieving, the function of moisturizing laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty are just, and be heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Selecting Rhizoma Chuanxiong is because its nature and flavor suffering, and temperature, enter liver, gallbladder meridian, and activating QI to alleviate the depression is arranged, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain, control air-cooled headache revolve dizzy, hypochondriac pain abdomen pain, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Select Radix Rehmanniae Preparata to be because its nature and flavor are sweet, tepor, enter liver, kidney channel, and YIN nourishing is arranged, and the function of enriching blood is controlled deficiency of YIN insufficiency of blood, the waist knee flaccidity, and the chronic cough hectic fever due to YIN-deficiency, seminal emission, metrorrhagia, menoxenia, quench one's thirst, frequency of micturition, deafness, blurred vision.Select the Radix Paeoniae Alba to be because its nature and flavor picric acid is cool, enter liver, spleen channel, nourishing blood to suppress the hyperactive liver is arranged, slow middle pain relieving, yin fluid astringing is received the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select Radix Panacis Quinquefolii to be because its property sweet and slightly bitter taste is cool, enter the heart, lung, kidney three warps, useful lung yin, clear asthenic fire, the function of promoting the production of body fluid to quench thirst, control deficiency of the lung chronic cough, loses blood, dry throat and mouth, deficiency-heat is tired tired.Select the Radix Astragali to be because its nature and flavor are sweet, tepor, enter lung, spleen channel, give birth to the useful consolidating superficial resistance of defending, and inducing diuresis to remove edema, poison holding, the function of granulation promoting, control spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle are not burst or are burst and hold back for a long time; Process with the function that the invigorating middle warmer benefit is arranged, control the internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select Poria to be because its property slightly sweet flavor is flat, enter the heart, spleen, lung meridian, eliminating dampness and diuresis is arranged, the strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, control dysuria edema distending pain, the phlegm retention cough with dyspnea, the sound of vomiting of vomitting, have loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Selecting the Rhizoma Atractylodis Macrocephalae is because its property bitter but sweet flavor, and temperature, enter spleen, stomach warp, and spleen reinforcing is arranged, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, the asthenia weak breath, deficiency-distension, have loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizziness, spontaneous perspiration, nausea uneasiness.Selecting Cortex Cinnamomi is that heat, enter kidney, spleen, urinary bladder channel, and the complement sun is arranged, warming the spleen and stomach, removing accumulated cold because of its property acrid-sweet flavor, the function of promoting blood circulation, control decline of the fire from the gate of life, the cold extremities faint pulse, and the YANG-depletion collapse, stomachache is had loose bowels, the colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea and mass in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.Selecting Radix Aconiti Lateralis Preparata is because of its property acrid-sweet flavor, and heat is poisonous, enter the heart, spleen, kidney channel, have recuperating depleted YANG to mend fire, the function of dispelling cold and removing dampness, control excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhea is fainted contrary, trusted subordinate's cold type of pain, the splenic diarrhea cold-dysentery, beriberi edema, children's's intermittent infantile convulsion, the contracture of anemofrigid-damp arthralgia ， Wei lame, the disease of the leakage of carbuncle of yin nature skin ulcer and all chronic diseaseses.Selecting Rhizoma Zingiberis Recens is because its nature and flavor suffering, and temperature, enter lung, stomach, spleen channel, deliver, and cold expelling, preventing or arresting vomiting, open the function of expectorant, the wind and cold that cures cold, vomiting, phlegm retention, breath with cough, and distension is had loose bowels, and separates the Rhizoma Pinelliae, Rhizoma Arisaematis and fish Eriocheir sinensis, birds and beasts meat poisoning.Selecting Fructus Schisandrae Chinensis is that temperature, enter lung, kidney channel, astringes the lung because of its nature and flavor acid, and nourishing kidney, promote the production of body fluid, and receives antiperspirant, and the function of arresting seminal emission, control the deficiency of the lung and breath with cough, and xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery; Selecting the Herba Lycopi is that tepor, enter liver, spleen channel because of its nature and flavor toil, invigorates blood circulation, and the function of row water, control amenorrhea ， mass in the abdomen, the stagnant stomachache of the stasis of blood in puerperal, body and face edema, injury from falling down, incised wound, carbuncle.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, detoxifcation, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach lack of appetite, stomachache loose stool, the overstrain heating, consumptive lung disease cough, cardiopalmus, frightened carbuncle, give birth to controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separate poison of drug and alimentary toxicosis.

The specific embodiment

The drug dose of the present invention's combination is also that the inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect in the following weight scope

Radix Angelicae Sinensis 10-20 gram Rhizoma Chuanxiong 10-20 gram Radix Rehmanniae Preparata 10-20 grams

The Radix Paeoniae Alba 10-20 gram Radix Panacis Quinquefolii 10-20 gram Radix Astragali 10-20 grams

Poria 10-20 gram Rhizoma Atractylodis Macrocephalae 10-20 gram Cortex Cinnamomi 8-15 grams

Radix Aconiti Lateralis Preparata 8-15 gram Rhizoma Zingiberis Recens 8-15 gram Fructus Schisandrae Chinensis 8-15 grams

Herba Lycopi's 8-15 gram Radix Glycyrrhizae 8-15 grams

Preferable amount is

Radix Angelicae Sinensis 15 gram Rhizoma Chuanxiong 15 gram Radix Rehmanniae Preparata 15 grams

The Radix Paeoniae Alba 15 gram Radix Panacis Quinquefolii 15 gram Radix Astragali 15 grams

The Poria 15 gram Rhizoma Atractylodis Macrocephalae 15 gram Cortex Cinnamomi 10 grams

Radix Aconiti Lateralis Preparata 10 gram Rhizoma Zingiberis Recens 10 gram Fructus Schisandrae Chinensis 10 grams

Herba Lycopi's 10 gram Radix Glycyrrhizae 10 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Radix Angelicae Sinensis: choose decontamination, clean, run through, section is dried;

2, Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, after moistening, cuts into slices, and drying;

3, Radix Rehmanniae Preparata: get crude drug, steam to surperficial corvinus, take out, shine while doing to eighty per cant section, drying;

4, the Radix Paeoniae Alba: choose decontamination, size separately, be soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, section, drying;

5, Radix Panacis Quinquefolii: former medicinal clear water spray tide, cover wet cloth, Xia Qiu profit 2 days, Winter-Spring profit 3 days, take out section, dries;

6, the Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water;

7, Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;

8, the Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, after bubble, pull out, run through, section, dry;

9, Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the used time smashes, or scrapes off rough bark, with warm water, infiltrates a moment, and section, dry;

10, Radix Aconiti Lateralis Preparata: get Radix Aconiti Lateralis Preparata and clean, clear water soaks a night, except peeling umbilicus, section, add again blister to mouth and taste and spicy sense is slightly arranged for degree, take out, with ginger decoction, soak 1-3 days, then cook, roast to seventy percent again and do, pour in pot urgent the stir-fry to cigarette of useing force into and rise, micro-drum splits for degree, and taking-up cools;

11, Rhizoma Zingiberis Recens: choose decontamination, clean earth, the used time section;

12, Fructus Schisandrae Chinensis: sieve dedust bits, remove impurity, to put in food steamer and steam thoroughly, taking-up is dried;

13, Herba Lycopi: choose decontamination, remove undesirable root, water spray is profit slightly, and cutting is dried;

14, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly the time to eighty per cant, run through section, airing.

Two, preparation

1, the Radix Angelicae Sinensis of described weight, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Panacis Quinquefolii, the Radix Astragali, Poria, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Lycopi, Radix Glycyrrhizae medicine are added to 6 times of water gagings, soak after 180 minutes, intense fire decocts boiling 10 minutes, use again slow fire boiling 25 minutes, and filtered to obtain decoction liquor for the first time.

2, the medicinal residues of filtration are added to 4 times of amounts of water, intense fire decocts boiling 15 minutes, then uses slow fire boiling 15 minutes, filters to obtain decoction liquor for the second time.

3, twice decoction liquor merged, then simmered in water 15 minutes, will decoct medicinal liquid and be divided into 3 doses and take.

Medicine of the present invention has benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, and dispeiling pathogenic wind and removing dampness, the complement sun, warming the spleen and stomach, the effect of removing accumulated cold, treatment puerperal exposure to wind instant effect, short treating period, do not recur.

Below by test example, further set forth the beneficial effect of medicine of the present invention, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get 40 of rabbit, the male and female dual-purpose, body weight 2.0-2.3kg, divide two groups, and 20 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is the administration by gavage administration, and every day, secondary, serve on 7 days, observes the administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's 220 examples for medical treatment.

2, diagnostic criteria

Clinical manifestation

The whole body joint, hands, foot, waist, shoulder, sole has ache, and numbness is afraid of cold, eyes are uncomfortable, and aversion to wind is shed tears, menoxenia, the group of being with, band is black, is with white phenomenon, lower abdomen meeting flatulence, air-blowing, the sensation of micro-pain, face is partially yellow, memory, and sexual life obviously descends, the phenomenon such as diet is not good, and defecation is abnormal.

3, Therapeutic Method

Select above-mentioned medicament, to the patient, take, each serving with 1 dose, every day early, middle and late respectively the clothes 1 time, 7 days is a course for the treatment of, takes continuously 5 courses for the treatment of.

4, efficacy assessment standard

Produce effects: puerperal exposure to wind is eliminated, and observes after half a year without recurrence;

Take a turn for the better: the puerperal exposure to wind symptom is clearly better;

Invalid: symptom, without improvement, does not reach improvement standard person.

5, therapeutic outcome

In above-mentioned treatment, with Drug therapy puerperal exposure to wind patient of the present invention 220 examples, produce effects 212 examples as a result, obvious effective rate is 96.36%, 5 examples that take a turn for the better, improvement rate is 2.27%, invalid 3 examples, total effective rate is 98.63%.

Claims

1. medicine for the treatment of puerperal exposure to wind, it is characterized in that: it is to be made by the crude drug in following weight range:

Herba Lycopi's 8-15 gram Radix Glycyrrhizae 8-15 grams.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Herba Lycopi's 10 gram Radix Glycyrrhizae 10 grams.

3. the preparation method of described medicine according to claim 1 and 2, it comprises the following steps:

(1) get the raw materials ready

(1) Radix Angelicae Sinensis: choose decontamination, clean, run through, section is dried;

(2) Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, after moistening, cuts into slices, and drying;

(3) Radix Rehmanniae Preparata: get crude drug, steam to surperficial corvinus, take out, shine while doing to eighty per cant section, drying;

(4) Radix Paeoniae Alba: choose decontamination, size separately, be soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, section, drying;

(5) Radix Panacis Quinquefolii: former medicinal clear water spray tide, cover wet cloth, Xia Qiu profit 2 days, Winter-Spring profit 3 days, take out section, dries;

(6) Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water;

(7) Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;

(8) Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, after bubble, pull out, run through, section, dry;

(9) Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the used time smashes, or scrapes off rough bark, with warm water, infiltrates a moment, and section, dry;

(10) Radix Aconiti Lateralis Preparata: get Radix Aconiti Lateralis Preparata and clean, clear water soaks a night, except peeling umbilicus, section, add again blister to mouth and taste and spicy sense is slightly arranged for degree, take out, with ginger decoction, soak 1-3 days, then cook, roast to seventy percent again and do, pour in pot urgent the stir-fry to cigarette of useing force into and rise, micro-drum splits for degree, and taking-up cools;

(11) Rhizoma Zingiberis Recens: choose decontamination, clean earth, the used time section;

(12) Fructus Schisandrae Chinensis: sieve dedust bits, remove impurity, to put in food steamer and steam thoroughly, taking-up is dried;

(13) Herba Lycopi: choose decontamination, remove undesirable root, water spray is profit slightly, and cutting is dried;

(14) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly the time to eighty per cant, run through section, airing;

(2) preparation

(1) Radix Angelicae Sinensis of described weight, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Panacis Quinquefolii, the Radix Astragali, Poria, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis Recens, Fructus Schisandrae Chinensis, Herba Lycopi, Radix Glycyrrhizae medicine are added to 6 times of water gagings, soak after 180 minutes, intense fire decocts boiling 10 minutes, use again slow fire boiling 25 minutes, and filtered to obtain decoction liquor for the first time;

(2) medicinal residues of filtration are added to 4 times of amounts of water, intense fire decocts boiling 15 minutes, then uses slow fire boiling 15 minutes, filters to obtain decoction liquor for the second time;

(3) twice decoction liquor merged, then simmered in water 15 minutes, will decoct medicinal liquid and be divided into 3 doses and take.