CN102228644B - Medicament for treating thyrocele and preparation method thereof - Google Patents

Abstract

The invention discloses a medicament for treating thyrocele, which is mainly prepared from szechuan tangshen root, szechuan tangshen root, dwarf lilyturf tuber, figwort root, pinellia tuber and heterophylly falsestarwort root according to a certain weight ratio. The medicament treating the thyrocele has the effects of inducing diuresis, relieving swelling and promoting pus discharge and tissue regeneration, and is quick in curative effect and high in cure rate.

Description

A kind of medicine for the treatment of thyromegaly and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of thyromegaly, belong to the field of Chinese medicines.

Background technology

Thyromegaly is one of a kind of multiple commonly encountered diseases, from the beginning of there not being classical symptom, and the gradually chap of later head and neck, dry cough appears in patient's weak discomfort of neck area sometimes, hoarseness, dysphagia affects work and sleep.But present medicine symptomatic treatment relief of symptoms such as the multiplex thyroxine sheet of western medical treatment or oral potassium iodide, but western medicine can not effect a radical cure, easily recurrence, curative effect is also not obvious.

Summary of the invention

Therefore, there is great demand in people to the better Chinese medicine of curative effect, up to now, also do not find the relevant report about medicine of the present invention, the inventor is through repeatedly research, and the repeatedly checking by animal and clinical trial, finally find the oral medicinal herb medicine that the treatment of better curative effect thyromegaly is arranged, thereby finished the present invention.

Purpose of the present invention just provides a kind of a kind of Chinese medicine composition of more effectively treating thyromegaly.

Another object of the present invention has just provided the preparation method of this Chinese medicine composition.

Medicine of the present invention selects Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Radix Scrophulariae, the Rhizoma Pinelliae, Radix Pseudostellariae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Alismatis, the Radix Astragali, Fructus Corni, Radix Salviae Miltiorrhizae, Fructus Hordei Germinatus, Pericarpium Citri Reticulatae and Radix Glycyrrhizae to make up, with these drug regimens, so that each efficacy of drugs produces synergism, thereby can effectively treat the recurrence of thyromegaly, wherein select Radix Codonopsis to be because its nature and flavor are sweet, flat, start with, meridian of Foot-TAI YIN, invigorating the spleen and replenishing QI is arranged, the function of promoting the production of body fluid, control weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea, proctoptosis.Selecting the Rhizoma Atractylodis Macrocephalae is because its property bitter but sweet flavor, and temperature enters spleen, stomach warp, and spleen reinforcing is arranged, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, the asthenia weak breath, deficiency-distension is had loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizziness, spontaneous perspiration, nausea is uneasy.Select be Radix Ophiopogonis because its property sweet and slightly bitter taste is cold, enter lung, stomach, heart channel, nourishing YIN and moistening the lung is arranged, the relieving restlessness that clears away heart-fire, the function of reinforcing stomach reg fluid is controlled dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, the asthenia dysphoria with smothery sensation, clear thirsty, hinder in calentura Tianjin, dry mouth and throat, constipation.Select Radix Scrophulariae to be because the bitter salty cold of its nature and flavor has YIN nourishing, pathogenic fire reducing, relieving restlessness, the function of detoxifcation is controlled the calentura excessive thirst, laryngopharynx swelling and pain, carbuncle scrofula.Select the Rhizoma Pinelliae to be because its nature and flavor are hot, temperature, poisonous, enter spleen, stomach warp, drying dampness to eliminate phlegm is arranged, stopping nausea and vomiting by lowering the adverse flow of QI, the function of dissolving lump and resolving mass is controlled the damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm headache, dizzy sleeplessness, outer subduing inflammation.Selecting Radix Pseudostellariae is that tepor enters the heart, spleen, lung three warps, and the function of tonifying the lung, spleen invigorating is arranged, and controls the cough due to deficiency of the lung because of its nature and flavor sweetness and bitterness, insufficiency of the spleen lack of appetite, and cardiopalmus and antiperspirant, spirit is tired.Selecting Radix Angelicae Sinensis is that temperature enters the heart, liver, spleen channel, and benefiting blood and regulating blood circulation is arranged, menstruction regulating and pain relieving, the function of moisturizing laxation because of the sweet suffering of its nature and flavor, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty are just, and be heavy after the bloody dysentery, ulcer sores, incised wound, injury from falling down.Selecting the Radix Paeoniae Alba is that cold enters liver, spleen channel, and nourishing blood to suppress the hyperactive liver is arranged because of its nature and flavor picric acid, slow middle pain relieving, and yin fluid astringing is received the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select Poria to be because its property slightly sweet flavor is flat, enter the heart, spleen, lung meridian, eliminating dampness and diuresis is arranged, the strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming is controlled dysuria edema distending pain, the phlegm retention cough with dyspnea, the sound of vomiting of vomitting is had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Select Rhizoma Alismatis to be because its nature and flavor are sweet, cold, enter urinary bladder channel, diuretic is arranged, eliminating dampness by diuresis, the function that expels the heat-evil is controlled dysuria, and the edema anus is full, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.Select the Radix Astragali to be because its nature and flavor are sweet, tepor enters lung, spleen channel, give birth to the useful consolidating superficial resistance of defending, and inducing diuresis to remove edema, poison holding, the function of granulation promoting is controlled spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle are not burst or are burst and hold back for a long time; Process with the function that invigorating the spleen and replenishing QI is arranged, control the internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select Fructus Corni to be because its nature and flavor acid tepor is included into liver, kidney channel, tonifying liver is arranged, kidney is puckery, the function that vital essence is collapsed admittedly, control dizzy, tinnitus, deficiency of the liver cold and heat, sexual impotence, seminal emission.Select Radix Salviae Miltiorrhizae to be because its nature and flavor are bitter, tepor enters the heart, Liver Channel, and blood circulation and promoting silt is arranged, calming heart and tranquilizing mind, and evacuation of pus, the function of pain relieving is controlled angina cordis, menoxenia, dysmenorrhea, to close, metrorrhagia leukorrhagia ， mass in the abdomen gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.Select Fructus Hordei Germinatus to be because its nature and flavor are sweet, tepor enters spleen, stomach warp, have to help digestion, and in, the function of the therapeutic method to keep the adverse QI flowing downwards is controlled food stagnation and is not disappeared, swollen distention and fullness in the abdomen, and inappetence, vomiting is had loose bowels, and mammary swelling does not disappear.Select Pericarpium Citri Reticulatae to be because its nature and flavor are bitter, hot, temperature is returned lung, spleen channel, and regulating qi-flowing for strengthening spleen is arranged, and the function of drying dampness to eliminate phlegm is controlled fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, detoxifcation, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, the overstrain heating, consumptive lung disease cough, cardiopalmus, frightened carbuncle is given birth to controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores is separated poison of drug and alimentary toxicosis.

The consumption of drug component of the present invention also carries out a large amount of Exploration and conclusions through the inventor and draws, and the consumption of each component is for all having preferably curative effect in the following weight scope.

Radix Codonopsis 10-20 gram Rhizoma Atractylodis Macrocephalaes 10-20 gram grams Radix Ophiopogonis 8-15

Radix Scrophulariae 10-20 gram Rhizoma Pinelliaes 8-15 gram Radix Pseudostellariaes 10-20 grams

Radix Angelicae Sinensis 8-15 gram Radix Paeoniae Albas 10-20 gram Poria 8-15 grams

Rhizoma Alismatis 10-20 gram Radixs Astragali 25-35 Keshan Fructus Evodiaes 10-20 grams

Radix Salviae Miltiorrhizae 10-20 gram Fructus Hordei Germinatus 10-20 gram Pericarpium Citri Reticulataes 5-10 grams

Radix Glycyrrhizae 5-10 grams

Preferable amount is:

The Radix Codonopsis 15 gram Rhizoma Atractylodis Macrocephalaes 15 gram grams Radix Ophiopogonis 10

The Radix Scrophulariae 15 gram Rhizoma Pinelliaes 10 gram Radix Pseudostellariaes 15 grams

The Radix Angelicae Sinensis 10 gram Radix Paeoniae Albas 15 gram Poria 10 grams

The Rhizoma Alismatis 15 gram Radixs Astragali 30 Keshan Fructus Evodiaes 15 grams

Radix Salviae Miltiorrhizae 15 gram Fructus Hordei Germinatus 15 gram Pericarpium Citri Reticulataes 5 grams

Radix Glycyrrhizae 5 grams

Preparation method of the present invention is as follows

One, gets the raw materials ready

1, Radix Codonopsis: run through reed after cleaning silt, section or cutting are dried;

2, the Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out behind the bubble, run through, section is dried;

3, Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, take out the heart after running through, clean again and dry;

4, Radix Scrophulariae: choose clean impurity, except removing LU, clean running through, section is dried;

5, the Rhizoma Pinelliae: choose decontamination, sieve dedust bits;

6, Radix Pseudostellariae: clean silt, section or cutting are dried;

7, Radix Angelicae Sinensis: choose roguing and sanction, clean, moistening slightly dries in the air when suitable to inside and outside humidity, and section is dried;

8, the Radix Paeoniae Alba: choose roguing and sanction, size separately is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;

9, Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;

10, Rhizoma Alismatis: choose decontamination, big or small stepping is soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section is cut dried;

11, the Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;

12, Fructus Corni: clean, except removal core and impurity, dry;

13, Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;

14, Fructus Hordei Germinatus (parched): get Fructus Hordei Germinatus and put pot interior little stir-fry to yellow, taking-up cools;

15, Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, moistens softly, and shredding is dried or cold drying, sieve dedust bits;

16, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant thoroughly the time, pull out, run through section, airing.

Two, preparation

1, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Radix Scrophulariae, the Rhizoma Pinelliae, Radix Pseudostellariae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Alismatis, the Radix Astragali, Fructus Corni, Radix Salviae Miltiorrhizae, Fructus Hordei Germinatus, Pericarpium Citri Reticulatae, the Radix Glycyrrhizae of described weight proportion being put into the container of boiling medicine decocts with water, add for the first time 2 times of amounts of water, intense fire decocted 30 minutes, used again slow fire boiling 20 minutes, namely get for the first time decoction liquor, be the liquid of taking medicine patient's morning.

2, the medicinal residues after for the first time filtration add 1.5 times of amounts of water, decoct boiling and use slow fire boiling 20 minutes again, namely get for the second time decoction liquor, are the liquid of taking medicine patient's evening.

Medicine of the present invention has benefit and defends consolidating superficial resistance, inducing diuresis to remove edema, and the function of promoting pus discharge and tissue regeneration strengthening is used for the treatment of the thyromegaly curative effect fast, and cure rate is high.

The specific embodiment

Below further set forth the relevant effect of medicine of the present invention by test example, these tests comprise the animal toxicity test of medicine of the present invention and clinical observation test.

[test example 1] animal toxicity test data

Get 20 of West Germany rabbits, male and female dual-purpose, body weight 2-2.5kg, divide two groups, 10 every group, wherein one group is the overdose test group, two groups is the normal amount test group, the overdose group is 30ml/kg, and normal amount is 10ml/kg, and administering mode is the administration by gavage administration, twice of every day, serve on seven days, observe the administration reaction every day, the result shows that the movable diet of two groups of rabbit is normal.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data:

Accept out-patient's 30 examples for medical treatment, male 19 examples wherein, women 11 examples, 10-20 years old age, 6 examples, 21-30 years old 8 example, 31-40 years old 10 example, 6 examples more than 40 years old.

2, diagnostic criteria:

At the ill initial stage, patient feels off color, discomfort of neck area, loss of appetite, poor appetite, dry cough sometimes, hoarseness, the progressively chap of later cervical region, dysphagia.

3, Therapeutic Method:

Every day is oral twice, sooner or later each once, according to the above-mentioned mode decoction of boiling medicine, ten days is a course for the treatment of, serve on three courses for the treatment of.

4, efficacy assessment standard:

Produce effects: patient's spirit, diet recover normal, observe 1 year without the recidivist;

Take a turn for the better: patient's spirit and diet recover normal, and cervical region is subsided a swelling gradually and recovered normal;

Invalid: as not reach improvement standard person.

5, therapeutic outcome:

In three courses for the treatment of, with Drug therapy thyromegaly patient 30 examples of the present invention, produce effects 24 examples as a result, 5 examples that take a turn for the better, invalid 1 example, obvious effective rate 80%, improvement rate 16.6%, total effective rate are 96.6%.

Claims (3)

1. medicine for the treatment of thyromegaly, it is characterized in that: it is to be made by the crude drug in the following weight range:

Radix Codonopsis 10-20 gram Rhizoma Atractylodis Macrocephalaes 10-20 gram grams Radix Ophiopogonis 8-15

Radix Scrophulariae 10-20 gram Rhizoma Pinelliaes 8-15 gram Radix Pseudostellariaes 10-20 grams

Radix Angelicae Sinensis 8-15 gram Radix Paeoniae Albas 10-20 gram Poria 8-15 grams

Rhizoma Alismatis 10-20 gram Radixs Astragali 25-35 Keshan Fructus Evodiaes 10-20 grams

Radix Salviae Miltiorrhizae 10-20 gram Fructus Hordei Germinatus 10-20 gram Pericarpium Citri Reticulataes 5-10 grams

Radix Glycyrrhizae 5-10 grams;

Preparation method is the following step:

(1) gets the raw materials ready

(1) Radix Codonopsis: run through reed after cleaning silt, section or cutting are dried;

(2) Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out behind the bubble, run through, section is dried;

(3) Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, take out the heart after running through, clean again and dry;

(4) Radix Scrophulariae: choose clean impurity, except removing LU, clean running through, section is dried;

(5) Rhizoma Pinelliae: choose decontamination, sieve dedust bits;

(6) Radix Pseudostellariae: clean silt, section or cutting are dried;

(7) Radix Angelicae Sinensis: choose roguing and sanction, clean, moistening slightly dries in the air when suitable to inside and outside humidity, and section is dried;

(8) Radix Paeoniae Alba: choose roguing and sanction, size separately is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;

(9) Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;

(10) Rhizoma Alismatis: choose decontamination, big or small stepping is soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section is cut dried;

(11) Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;

(12) Fructus Corni: clean, except removal core and impurity, dry;

(13) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;

(14) Fructus Hordei Germinatus (parched): get Fructus Hordei Germinatus and put pot interior little stir-fry to yellow, taking-up cools;

(15) Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, moistens softly, and shredding is dried or cold drying, sieve dedust bits;

(16) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant thoroughly the time, pull out, run through section, airing;

(2) preparation

(1) Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Radix Scrophulariae, the Rhizoma Pinelliae, Radix Pseudostellariae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Alismatis, the Radix Astragali, Fructus Corni, Radix Salviae Miltiorrhizae, Fructus Hordei Germinatus, Pericarpium Citri Reticulatae, the Radix Glycyrrhizae of described weight proportion being put into the container of boiling medicine decocts with water, add for the first time 2 times of amounts of water, intense fire decocted 30 minutes, used again slow fire boiling 20 minutes, namely get for the first time decoction liquor, be the liquid of taking medicine patient's morning;

(2) medicinal residues after for the first time filtration add 1.5 times of amounts of water, decoct boiling and use slow fire boiling 20 minutes again, namely get for the second time decoction liquor, are the liquid of taking medicine patient's evening.

2. the medicine for the treatment of thyromegaly according to claim 1, it is characterized in that: wherein the consumption of each crude drug is:

The Radix Codonopsis 15 gram Rhizoma Atractylodis Macrocephalaes 15 gram grams Radix Ophiopogonis 10

The Radix Scrophulariae 15 gram Rhizoma Pinelliaes 10 gram Radix Pseudostellariaes 15 grams

The Radix Angelicae Sinensis 10 gram Radix Paeoniae Albas 15 gram Poria 10 grams

The Rhizoma Alismatis 15 gram Radixs Astragali 30 Keshan Fructus Evodiaes 15 grams

Radix Salviae Miltiorrhizae 15 gram Fructus Hordei Germinatus 15 gram Pericarpium Citri Reticulataes 5 grams

Radix Glycyrrhizae 5 grams.

3. the preparation method of described medicine according to claim 1 and 2, it is characterized in that: it is made by the following step:

(1) gets the raw materials ready

(1) Radix Codonopsis: run through reed after cleaning silt, section or cutting are dried;

(2) Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out behind the bubble, run through, section is dried;

(3) Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, take out the heart after running through, clean again and dry;

(4) Radix Scrophulariae: choose clean impurity, except removing LU, clean running through, section is dried;

(5) Rhizoma Pinelliae: choose decontamination, sieve dedust bits;

(6) Radix Pseudostellariae: clean silt, section or cutting are dried;

(7) Radix Angelicae Sinensis: choose roguing and sanction, clean, moistening slightly dries in the air when suitable to inside and outside humidity, and section is dried;

(8) Radix Paeoniae Alba: choose roguing and sanction, size separately is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;

(9) Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;

(10) Rhizoma Alismatis: choose decontamination, big or small stepping is soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section is cut dried;

(11) Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;

(12) Fructus Corni: clean, except removal core and impurity, dry;

(13) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;

(14) Fructus Hordei Germinatus (parched): get Fructus Hordei Germinatus and put pot interior little stir-fry to yellow, taking-up cools;

(15) Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, moistens softly, and shredding is dried or cold drying, sieve dedust bits;

(16) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant thoroughly the time, pull out, run through section, airing;

(2) preparation

(1) Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Radix Scrophulariae, the Rhizoma Pinelliae, Radix Pseudostellariae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Alismatis, the Radix Astragali, Fructus Corni, Radix Salviae Miltiorrhizae, Fructus Hordei Germinatus, Pericarpium Citri Reticulatae, the Radix Glycyrrhizae of described weight proportion being put into the container of boiling medicine decocts with water, add for the first time 2 times of amounts of water, intense fire decocted 30 minutes, used again slow fire boiling 20 minutes, namely get for the first time decoction liquor, be the liquid of taking medicine patient's morning;

(2) medicinal residues after for the first time filtration add 1.5 times of amounts of water, decoct boiling and use slow fire boiling 20 minutes again, namely get for the second time decoction liquor, are the liquid of taking medicine patient's evening.