CN105148022A - Preparation for treating senile dementia and preparation method - Google Patents
Preparation for treating senile dementia and preparation method Download PDFInfo
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Abstract
The invention discloses a preparation for treating senile dementia. The preparation is mainly prepared from, by mass, 9-15 parts of ginseng, 7-13 parts of elaeagnus pungens, 8-14 parts of crepis crocea, 10-16 parts of polygonum chinense, 9-14 parts of vetch, 7-15 parts of cassia bud, 9-16 parts of beautiful phyllodium twig and leaf, 8-13 parts of drynaria total flavonoids, 10-14 pars of ipomoea pescaprae, 9-13 parts of japonica China fern rhizome, 7-14 parts of anoectochilus roxburghii, 11-15 parts of nuphar pumila root, 10-13 parts of fructus schizandrae and 9-12 parts of leontopodium leontopodioides. The preparation is a pure traditional Chinese medicine preparation, and is high in safety, wide in application range and capable of being easily accepted by patients; the preparation is developed according to the traditional Chinese medicine principle, has effects on tonifying kidney and strengthening bone, soothing nerves and restoring consciousness and the like, and is good in curative effect, free of side effects, low in cost and free of economic loads during long-term use.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of prescription and preparation method for the treatment of senile dementia.
Background technology
Alzheimer, be alzheimer disease again, it is a kind of PDCD occurring in Senectitude and presenium, refer to a kind of persistence higher nerve functional activity obstacle, namely under the state not having disturbance of consciousness, memory, thinking, analysis judge, the obstacle of the aspects such as visual space identification, emotion.Main manifestations is the neuropsychic symptoms such as gradual memory obstacle, cognitive dysfunction, personality changes and aphasis, has a strong impact on social activity, occupation and vital function.Its characteristic pathological is changed to atrophy of cerebral cortex, and with amyloid-beta deposition, neurofibrillary tangles, mass memory neuron number reduces, and the formation of senile plaque.This sick insidious onset, spirit changes concealment, and be difficult to be aware in early days, classical symptom has activity of daily living to go down and dystropy, and recent amnesia phenomenon is One's eyesight is restrained, forgetful, cognitive dysfunction and memory disorder.Because the cause of disease of AD and pathogenesis are not yet clear and definite, treatment there is no specific short, can only based on symptomatic treatment.Comprise Drug therapy and improve cognitive function and dysmnesia, symptomatic treatment improves mental symptom, and good nursing delays disease progression.Medicine and rehabilitation, to improve cognition and memory function, keep the independent living ability of patient, improve for the purpose of life quality.
Publication No. CN104645029A(application number 201510051156.7) Chinese patent literature disclose a kind of medicine for the treatment of senile dementia, the weight ratio of each component is Radix Ginseng 3-7 part, Fructus Lycii 5-15 part, Herba Cistanches 4-6 part, Radix Ophiopogonis 5-12 part, Poria 4-12 part, Radix Polygalae 3-8 part, Radix Scutellariae 5-9 part, Rhizoma Polygonati 7-13 part, Cordyceps 1-3 part, Rhizoma Atractylodis Macrocephalae 4-8 part, Semen Ziziphi Spinosae 5-9 part, Radix Codonopsis 4-9 part, Carapax et Plastrum Testudinis 2-6 part, Radix Achyranthis Bidentatae 2-5 part, Placenta Hominis 3-9 part, Radix Rehmanniae 4-12 part, Radix Rehmanniae Preparata 4-12 part.Publication No. CN104083580A(application number 201410340013.3) Chinese patent literature disclose one and treat senile dementia Chinese medicine, be prepared from by following bulk drugs Radix Angelicae Sinensis 15-22, Rhizoma Atractylodis Macrocephalae 15-22, Radix Paeoniae Alba 15-22, Carapax et Plastrum Testudinis 18-22, Os Draconis 18-22, Radix Rehmanniae Preparata 10-20, Rhizoma Dioscoreae 10-20, Fructus Corni 10-20, Radix Rehmanniae 10-20, Radix Codonopsis 10-15, Radix Astragali 10-15, Poria 10-15, Semen Ziziphi Spinosae 10-15, Rhizoma Alismatis 10-15, Fructus Schisandrae Chinensis 8-12, Rhizoma Acori Graminei 8-12, Rhizoma Chuanxiong 8-12, Radix Polygalae 6-10.Publication No. CN102940834A(application number 201210381584.2) Chinese patent literature disclose a kind of Chinese medicine for the treatment of senile dementia, consist of Radix Rhodiolae 8-10, Radix Polygalae 8-10, Ramulus Uncariae Cum Uncis 10-12, Rhizoma Acori Graminei 8-10, Poria 10-12, Concha Haliotidis 8-10, Ganoderma 10-12, Herba Ludwigiae Prostratae 5-8, Radix Notoginseng 3-5, Radix Angelicae Sinensis 10-12, white drum nail 10-12, Scorpio 5-8, Fructus Alpiniae Oxyphyllae 10-12, Rhizoma Chuanxiong 5-8, Flos Caryophylli 3-5.
Long-term taking Western medicine, curative effect is very micro-, and easily produces dependency, and side effect is obvious, and Chinese native medicine security is high, easy long-term taking, stable curative effect, therefore can develop a kind of good effect according to determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs principle, the Chinese medicine preparation of the treatment senile dementia that safety is high.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of prescription and the preparation method of preparing the treatment senile dementia of simple, taking convenience.
Technical scheme of the present invention is:
The prescription for the treatment of senile dementia, is prepared from primarily of following bulk drugs, is mass parts: Radix Ginseng 9-15, Fructus Elaeagni 7-13, Radix Crepidis elongatae 8-14, Herb Polygoni Chinensis 10-16, Herba Viviae Sativae 9-14, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 7-15, Ramulus et Folium Phyllodii Pulchelli 9-16, Rhizoma Drynariae 8-13, Herba Ipomoeae Pes-Capraes 10-14, rhizoma woodwardiae 9-13, Anoectochilus nefiliforme (Nakai) hara 7-14, Rhizoma nupharis pumili 11-15, Fructus Schisandrae Chinensis 10-13, Herba Leontopodii Leontopodioidis 9-12.
In preferred scheme, Radix Ginseng 10-14, Fructus Elaeagni 9-11, Radix Crepidis elongatae 10-12, Herb Polygoni Chinensis 12-14, Herba Viviae Sativae 11-12, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 9-13, Ramulus et Folium Phyllodii Pulchelli 11-14, Rhizoma Drynariae 10-11, Herba Ipomoeae Pes-Capraes 11-13, rhizoma woodwardiae 10-12, Anoectochilus nefiliforme (Nakai) hara 9-12, Rhizoma nupharis pumili 12-14, Fructus Schisandrae Chinensis 11-12, Herba Leontopodii Leontopodioidis 10-11.
Be more preferably, Radix Ginseng 12, Fructus Elaeagni 10, Radix Crepidis elongatae 11, Herb Polygoni Chinensis 13, Herba Viviae Sativae 11.5, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 11, Ramulus et Folium Phyllodii Pulchelli 12.5, Rhizoma Drynariae 10.5, Herba Ipomoeae Pes-Capraes 12, rhizoma woodwardiae 11, Anoectochilus nefiliforme (Nakai) hara 10.5, Rhizoma nupharis pumili 13, Fructus Schisandrae Chinensis 11.5, Herba Leontopodii Leontopodioidis 10.5.
The prescription of described treatment senile dementia, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Radix Ginseng and Radix Crepidis elongatae to clean, section, add Radix Ginseng slice and Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat to stir-fry to surface in time yellow, takes out, dries in the air cool;
(2) get Herb Polygoni Chinensis, Herba Viviae Sativae, Ramulus et Folium Phyllodii Pulchelli, Herba Ipomoeae Pes-Capraes and Anoectochilus nefiliforme (Nakai) hara rice-washed water clean and infiltrate 20-30 minute (preferred, infiltrate 23-27 minute; Be more preferably, infiltrate 25 minutes), pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) Rhizoma nupharis pumili is scraped peeling, rice wine infiltrates 30 minutes, takes out, and after tight with toilet paper parcel, then uses salt water-soaked toilet paper, is placed in hot ash, simmer and become coke black to surperficial paper, take out, dry;
(4) Fructus Elaeagni, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, rhizoma woodwardiae, Fructus Schisandrae Chinensis and Herba Leontopodii Leontopodioidis are cleaned, soak 20 minutes, take out, decoct with water together with step (2) (3) made crude drug, big fire is boiled rear little fire and is decocted 33-45 minute (preferred, 36-42 minute decocted by little fire; Be more preferably, little fire decocts 39 minutes), filter, collect filtrate;
(5) step (1) made crude drug was pulverized 200 mesh sieves, made medicated powder, and joined in step (4) made filtrate, mix thoroughly, obtain decoction.
The preparation method of the prescription decoction of described treatment senile dementia, step (4) decocts the 7-9 that institute's amount of water is boiled crude drug quality and doubly (preferably, decocts 8 times that institute's amount of water is boiled crude drug quality).
The prescription of described treatment senile dementia, be made into pharmaceutically acceptable soft extract, its preparation method is:
(1) get Radix Ginseng and Radix Crepidis elongatae to clean, section, add Radix Ginseng slice and Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat to stir-fry to surface in time yellow, takes out, dries in the air cool, pulverized 200 mesh sieves, obtained medicated powder;
(2) get Herb Polygoni Chinensis, Herba Viviae Sativae, Ramulus et Folium Phyllodii Pulchelli, Herba Ipomoeae Pes-Capraes and Anoectochilus nefiliforme (Nakai) hara rice-washed water clean and infiltrate 20-30 minute (preferred, infiltrate 23-27 minute; Be more preferably, infiltrate 25 minutes), pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) Rhizoma nupharis pumili is scraped peeling, rice wine infiltrates 30 minutes, takes out, and after tight with toilet paper parcel, then uses salt water-soaked toilet paper, is placed in hot ash, simmer and become coke black to surperficial paper, take out, dry;
(4) Fructus Elaeagni, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, rhizoma woodwardiae, Fructus Schisandrae Chinensis and Herba Leontopodii Leontopodioidis are cleaned, soak 20 minutes, take out, decoct with water together with step (2) (3) made crude drug, institute's amount of water is 8 times of boiled crude drug quality, and big fire is boiled rear little fire and decocted, and filters, filtering residue decocts with water again, merges twice and decocts medicinal liquid;
(5) step (4) made medicinal liquid is brewed into clear paste, constantly stirs, add step (1) made medicated powder and mix thoroughly, then add refined honey mixing, obtain soft extract.
The preparation method of the prescription soft extract of described treatment senile dementia, step (4) big fire is boiled rear little fire and is decocted 33-45 minute (preferred, 36-42 minute decocted by little fire; Be more preferably, little fire decocts 39 minutes).
The prescription of described treatment senile dementia, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) get Radix Ginseng and Radix Crepidis elongatae to clean, section, add Radix Ginseng slice and Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat to stir-fry to surface in time yellow, takes out, dries in the air cool;
(2) get Herb Polygoni Chinensis, Herba Viviae Sativae, Ramulus et Folium Phyllodii Pulchelli, Herba Ipomoeae Pes-Capraes and Anoectochilus nefiliforme (Nakai) hara rice-washed water clean and infiltrate 20-30 minute (preferred, infiltrate 23-27 minute; Be more preferably, infiltrate 25 minutes), pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) Rhizoma nupharis pumili is scraped peeling, rice wine infiltrates 30 minutes, takes out, and after tight with toilet paper parcel, then uses salt water-soaked toilet paper, is placed in hot ash, simmer and become coke black to surperficial paper, take out, dry;
(4) Fructus Elaeagni, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, rhizoma woodwardiae, Fructus Schisandrae Chinensis and Herba Leontopodii Leontopodioidis are cleaned, soak 20 minutes post-heating to decoct, institute's amount of water is 8 times of boiled crude drug quality, and big fire is boiled rear little fire and decocted 33-45 minute (preferred, 36-42 minute decocted by little fire; Be more preferably, little fire decocts 39 minutes), filter, filtering residue decocts with water again, merges twice and decocts medicinal liquid, and spraying dry, pulverize and make dry thing powder;
(5) step (1) (2) (3) made crude drug is pulverized and sieved together, make medicated powder and mix with the made dry thing powder of step (4), mixed medicated powder is pressed into circular or other forms of tablet dosage form according to the preparation for processing of tablet, obtains tablet.
The preparation method of the prescription tablet of described treatment senile dementia, the dosage of medicated powder contained by the every sheet of step (5) is 0.25-0.35g/ sheet (preferred, contained by every sheet, the dosage of medicated powder is 0.30g/ sheet).
The prescription of described treatment senile dementia, be made into pharmaceutically acceptable electuary, its preparation method is:
(1) get Radix Ginseng and Radix Crepidis elongatae to clean, section, add Radix Ginseng slice and Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat to stir-fry to surface in time yellow, takes out, dries in the air cool, pulverized 200 mesh sieves, obtained medicated powder;
(2) get Herb Polygoni Chinensis, Herba Viviae Sativae, Ramulus et Folium Phyllodii Pulchelli, Herba Ipomoeae Pes-Capraes and Anoectochilus nefiliforme (Nakai) hara rice-washed water clean and infiltrate 20-30 minute (preferred, infiltrate 23-27 minute; Be more preferably, infiltrate 25 minutes), pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) Rhizoma nupharis pumili is scraped peeling, rice wine infiltrates 30 minutes, takes out, and after tight with toilet paper parcel, then uses salt water-soaked toilet paper, is placed in hot ash, simmer and become coke black to surperficial paper, take out, dry;
(4) Fructus Elaeagni, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, rhizoma woodwardiae, Fructus Schisandrae Chinensis and Herba Leontopodii Leontopodioidis are cleaned, soak 20 minutes, take out, decoct with water together with step (2) (3) made crude drug, amount of water is 8 times of boiled crude drug quality, big fire is boiled rear little fire and is decocted 33-45 minute (preferred, 36-42 minute decocted by little fire; Be more preferably, little fire decocts 39 minutes), filter, filtering residue decocts with water again, merges twice and decocts medicinal liquid;
(5) step (4) made medicine liquid spray be dry, pulverize into medicated powder, add step (1) made medicated powder and mix thoroughly, obtain electuary.
The preparation method of the prescription electuary of described treatment senile dementia, step (5) pulverized 200-300 mesh sieve (preferred, to pulverize 260 mesh sieves).
The prescription scientific formula for the treatment of senile dementia provided by the invention, the preparation method of various dosage form is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1, the present invention is pure Chinese medicinal preparation, and safety is high, and the suitability is wide, and patient easily accepts;
2, this prescription develops according to Chinese medicine principle, has the effects such as kidney tonifying bone strengthening, tranquilization and refreshment;
3, good effect of the present invention, has no adverse reaction, and cost is low, and long-term taking is without financial burden.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the prescription for the treatment of senile dementia, is prepared from (every part of 10g) primarily of following bulk drugs: Radix Ginseng 9 parts, Fructus Elaeagni 7 parts, Radix Crepidis elongatae 8 parts, Herb Polygoni Chinensis 10 parts, Herba Viviae Sativae 9 parts, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 7 parts, Ramulus et Folium Phyllodii Pulchelli 9 parts, Rhizoma Drynariae 8 parts, Herba Ipomoeae Pes-Capraes 10 parts, rhizoma woodwardiae 9 parts, Anoectochilus nefiliforme (Nakai) hara 7 parts, Rhizoma nupharis pumili 11 parts, Fructus Schisandrae Chinensis 10 parts, Herba Leontopodii Leontopodioidis 9 parts.
The preparation method of the prescription decoction of above-mentioned treatment senile dementia is:
(1) get Radix Ginseng and Radix Crepidis elongatae to clean, section, add Radix Ginseng slice and Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat to stir-fry to surface in time yellow, takes out, dries in the air cool;
(2) get Herb Polygoni Chinensis, Herba Viviae Sativae, Ramulus et Folium Phyllodii Pulchelli, Herba Ipomoeae Pes-Capraes and Anoectochilus nefiliforme (Nakai) hara rice-washed water clean and infiltrate 25 minutes, pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) Rhizoma nupharis pumili is scraped peeling, rice wine infiltrates 30 minutes, takes out, and after tight with toilet paper parcel, then uses salt water-soaked toilet paper, is placed in hot ash, simmer and become coke black to surperficial paper, take out, dry;
(4) Fructus Elaeagni, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, rhizoma woodwardiae, Fructus Schisandrae Chinensis and Herba Leontopodii Leontopodioidis are cleaned, soak 20 minutes, take out, decoct with water together with step (2) (3) made crude drug, amount of water is 8 times of boiled crude drug quality, big fire is boiled rear little fire and is decocted 39 minutes, filters, and collects filtrate;
(5) step (1) made crude drug was pulverized 200 mesh sieves, made medicated powder, and joined in step (4) made filtrate, mix thoroughly, obtain decoction.
embodiment 2the prescription for the treatment of senile dementia, is prepared from (every part of 10g) primarily of following bulk drugs: Radix Ginseng 15 parts, Fructus Elaeagni 13 parts, Radix Crepidis elongatae 14 parts, Herb Polygoni Chinensis 16 parts, Herba Viviae Sativae 14 parts, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 15 parts, Ramulus et Folium Phyllodii Pulchelli 16 parts, Rhizoma Drynariae 13 parts, Herba Ipomoeae Pes-Capraes 14 parts, rhizoma woodwardiae 13 parts, Anoectochilus nefiliforme (Nakai) hara 14 parts, Rhizoma nupharis pumili 15 parts, Fructus Schisandrae Chinensis 13 parts, Herba Leontopodii Leontopodioidis 12 parts.
The preparation method of the prescription soft extract for the treatment of senile dementia is:
(1) get Radix Ginseng and Radix Crepidis elongatae to clean, section, add Radix Ginseng slice and Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat to stir-fry to surface in time yellow, takes out, dries in the air cool, pulverized 200 mesh sieves, obtained medicated powder;
(2) get Herb Polygoni Chinensis, Herba Viviae Sativae, Ramulus et Folium Phyllodii Pulchelli, Herba Ipomoeae Pes-Capraes and Anoectochilus nefiliforme (Nakai) hara rice-washed water clean and infiltrate 25 minutes, pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) Rhizoma nupharis pumili is scraped peeling, rice wine infiltrates 30 minutes, takes out, and after tight with toilet paper parcel, then uses salt water-soaked toilet paper, is placed in hot ash, simmer and become coke black to surperficial paper, take out, dry;
(4) Fructus Elaeagni, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, rhizoma woodwardiae, Fructus Schisandrae Chinensis and Herba Leontopodii Leontopodioidis are cleaned, soak 20 minutes, take out, decoct with water together with step (2) (3) made crude drug, institute's amount of water is 8 times of boiled crude drug quality, and big fire is boiled rear little fire and decocted 39 minutes, filters, filtering residue decocts with water again, merges twice and decocts medicinal liquid;
(5) step (4) made medicinal liquid is brewed into clear paste, constantly stirs, add step (1) made medicated powder and mix thoroughly, then add refined honey mixing, obtain soft extract.
Model case: xxx, female, 70 years old.Suffer from senile dementia 2 years, nearly two weeks aggravations, dull expression, murmur to oneself repetition, be not familiar with household, do not exchange with the external world, appetite is few, apathetic expression, two is just normal, examination in hospital, memory, judges that computing power, identification ability and ability of thinking obviously go down, and is diagnosed as senile dementia.
Take the prescription soft extract of the present embodiment gained treatment senile dementia, every day 2 times, each 3-5g, warm boiled water, 30 days courses for the treatment of.After taking a course for the treatment of, appetite increases, and spirit is improved, do not murmur to oneself, after taking two courses for the treatment of, patient's memory improves, can be familiar with part household, and exchange with it, sleep is good, after taking four courses for the treatment of, patient mental is in good condition, and life can be taken care of oneself, be emotionally stable, patient clinical is fully recovered, and follow up a case by regular visits to after 1 year, patient body is in stable condition.
embodiment 3the prescription for the treatment of senile dementia, is prepared from (every part of 10g) primarily of following bulk drugs: Radix Ginseng 10 parts, Fructus Elaeagni 9 parts, Radix Crepidis elongatae 10 parts, Herb Polygoni Chinensis 12 parts, Herba Viviae Sativae 11 parts, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 9 parts, Ramulus et Folium Phyllodii Pulchelli 11 parts, Rhizoma Drynariae 10 parts, Herba Ipomoeae Pes-Capraes 11 parts, rhizoma woodwardiae 10 parts, Anoectochilus nefiliforme (Nakai) hara 9 parts, Rhizoma nupharis pumili 12 parts, Fructus Schisandrae Chinensis 11 parts, Herba Leontopodii Leontopodioidis 10 parts.
The preparation method of the prescription tablet for the treatment of senile dementia is:
(1) get Radix Ginseng and Radix Crepidis elongatae to clean, section, add Radix Ginseng slice and Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat to stir-fry to surface in time yellow, takes out, dries in the air cool;
(2) get Herb Polygoni Chinensis, Herba Viviae Sativae, Ramulus et Folium Phyllodii Pulchelli, Herba Ipomoeae Pes-Capraes and Anoectochilus nefiliforme (Nakai) hara rice-washed water clean and infiltrate 25 minutes, pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) Rhizoma nupharis pumili is scraped peeling, rice wine infiltrates 30 minutes, takes out, and after tight with toilet paper parcel, then uses salt water-soaked toilet paper, is placed in hot ash, simmer and become coke black to surperficial paper, take out, dry;
(4) Fructus Elaeagni, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, rhizoma woodwardiae, Fructus Schisandrae Chinensis and Herba Leontopodii Leontopodioidis are cleaned, soak 20 minutes post-heating to decoct, institute's amount of water is 8 times of boiled crude drug quality, big fire is boiled rear little fire and is decocted 39 minutes, filter, filtering residue decocts with water again, merges twice and decocts medicinal liquid, and spraying dry, pulverize and make dry thing powder;
(5) step (1) (2) (3) made crude drug is pulverized and sieved together, make medicated powder and mix with the made dry thing powder of step (4), mixed medicated powder is pressed into circular or other forms of tablet dosage form according to the preparation for processing of tablet, contained by every sheet, the dosage of medicated powder is 0.30g/ sheet, obtains tablet.
Model case: xxx, man, 75 years old.Within nearly 1 year, memory is faded, and rear appearance is cognitive, computing capability declines, baffled joyful, emotion comparatively fluctuates, personality change, after be not familiar with the road of going home, be not familiar with household, have a dull expression on one's face, be slow in action, urine pants is insensible to shame, appetite obviously reduces, examination in hospital, is diagnosed as senile dementia, hospitalization symptom is improved not obvious, then turns to Chinese traditional treatment.
Take the prescription tablet of the present embodiment gained treatment senile dementia, adopt every day 2 times, each 4, with warm water delivery service, 30 days courses for the treatment of.After taking a course for the treatment of, patient's memory improves, and emotion takes a turn for the better, and the mental status is improved, after taking two courses for the treatment of, Patients ' Cognitive ability improves, and can independently go home, after taking four courses for the treatment of, all diseases of patient disappear entirely, life can be taken care of oneself, and patient fully recovers, and follow up a case by regular visits to after 1 year, patient body state is in good health.
embodiment 4the prescription for the treatment of senile dementia, is prepared from (every part of 10g) primarily of following bulk drugs: Radix Ginseng 14 parts, Fructus Elaeagni 11 parts, Radix Crepidis elongatae 12 parts, Herb Polygoni Chinensis 14 parts, Herba Viviae Sativae 12 parts, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 13 parts, Ramulus et Folium Phyllodii Pulchelli 14 parts, Rhizoma Drynariae 11 parts, Herba Ipomoeae Pes-Capraes 13 parts, rhizoma woodwardiae 12 parts, Anoectochilus nefiliforme (Nakai) hara 12 parts, Rhizoma nupharis pumili 14 parts, Fructus Schisandrae Chinensis 12 parts, Herba Leontopodii Leontopodioidis 11 parts.
The preparation method of the prescription electuary for the treatment of senile dementia is:
(1) get Radix Ginseng and Radix Crepidis elongatae to clean, section, add Radix Ginseng slice and Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat to stir-fry to surface in time yellow, takes out, dries in the air cool, pulverized 200 mesh sieves, obtained medicated powder;
(2) get Herb Polygoni Chinensis, Herba Viviae Sativae, Ramulus et Folium Phyllodii Pulchelli, Herba Ipomoeae Pes-Capraes and Anoectochilus nefiliforme (Nakai) hara rice-washed water clean and infiltrate 25 minutes, pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) Rhizoma nupharis pumili is scraped peeling, rice wine infiltrates 30 minutes, takes out, and after tight with toilet paper parcel, then uses salt water-soaked toilet paper, is placed in hot ash, simmer and become coke black to surperficial paper, take out, dry;
(4) Fructus Elaeagni, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, rhizoma woodwardiae, Fructus Schisandrae Chinensis and Herba Leontopodii Leontopodioidis are cleaned, soak 20 minutes, take out, decoct with water together with step (2) (3) made crude drug, amount of water is 8 times of boiled crude drug quality, and big fire is boiled rear little fire and decocted 39 minutes, filters, filtering residue decocts with water again, merges twice and decocts medicinal liquid;
(5) step (4) made medicine liquid spray be dry, pulverize 260 mesh sieves and made medicated powder, and added step (1) made medicated powder and mix thoroughly, obtain electuary.
Model case: xxx, man, 60 years old.Started to occur hypomnesis before 2 years, sometimes obnubilation, have a dull expression on one's face, nearly half a year, hypomnesis is obvious, must not remember the road of going home, delay of response, cognitive, computing capability goes down, verbigeration, the large change of disposition, anxious state of mind is obvious, dystropy, expression is cold and detached, and be not even familiar with household, lethargy is depressed, malaise, examination in hospital, is diagnosed as senile dementia.
Take the prescription electuary of the present embodiment gained treatment senile dementia, adopt every day 2 times, each 4-5g, with warm boiled water, 30 days courses for the treatment of.After taking a course for the treatment of, patient mental takes a turn for the better, and sleep quality improves, weakly alleviate, after taking two courses for the treatment of, memory is improved, cognitive competence improves, and after taking four courses for the treatment of, patient's memory significantly improves, initiatively can exchange with people, understanding household, life can be taken care of oneself substantially, patient clinical is fully recovered, consolidate and take people course for the treatment of, follow up a case by regular visits to after 1 year, patient body is in good condition.
embodiment 5the prescription for the treatment of senile dementia, is prepared from (every part of 10g) primarily of following bulk drugs: Radix Ginseng 12 parts, Fructus Elaeagni 10 parts, Radix Crepidis elongatae 11 parts, Herb Polygoni Chinensis 13 parts, Herba Viviae Sativae 11.5 parts, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 11 parts, Ramulus et Folium Phyllodii Pulchelli 12.5 parts, Rhizoma Drynariae 10.5 parts, Herba Ipomoeae Pes-Capraes 12 parts, rhizoma woodwardiae 11 parts, Anoectochilus nefiliforme (Nakai) hara 10.5 parts, Rhizoma nupharis pumili 13 parts, Fructus Schisandrae Chinensis 11.5 parts, Herba Leontopodii Leontopodioidis 10.5 parts.
The preparation method of the prescription decoction for the treatment of senile dementia is:
(1) get Radix Ginseng and Radix Crepidis elongatae to clean, section, add Radix Ginseng slice and Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat to stir-fry to surface in time yellow, takes out, dries in the air cool;
(2) get Herb Polygoni Chinensis, Herba Viviae Sativae, Ramulus et Folium Phyllodii Pulchelli, Herba Ipomoeae Pes-Capraes and Anoectochilus nefiliforme (Nakai) hara rice-washed water clean and infiltrate 25 minutes, pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) Rhizoma nupharis pumili is scraped peeling, rice wine infiltrates 30 minutes, takes out, and after tight with toilet paper parcel, then uses salt water-soaked toilet paper, is placed in hot ash, simmer and become coke black to surperficial paper, take out, dry;
(4) Fructus Elaeagni, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, rhizoma woodwardiae, Fructus Schisandrae Chinensis and Herba Leontopodii Leontopodioidis are cleaned, soak 20 minutes, take out, decoct with water together with step (2) (3) made crude drug, amount of water is 8 times of boiled crude drug quality, big fire is boiled rear little fire and is decocted 39 minutes, filters, and collects filtrate;
(5) step (1) made crude drug was pulverized 200 mesh sieves, made medicated powder, and joined in step (4) made filtrate, mix thoroughly, obtain decoction.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Ginseng: base is former: be the root of Araliaceae Radix Ginseng.Nature and flavor: sweet, micro-hardship, tepor.Function cures mainly: QI invigorating, Gu de-, promote the production of body fluid, calms the nerves, Fructus Alpiniae Oxyphyllae.For dyspnea with shortness of breath, palpitation and amnesia, thirsty hyperhidrosis, lack of appetite is unable, all acute and chronic diseases and the shock caused after losing blood, collapse.
Fructus Elaeagni: base is former: be the fruit of Elaeangnaceae plant Fructus Elaeagni.Nature and flavor: acid is wet are flat.Function cures mainly: control dysentery, quenches one's thirst, and breathes with cough.
Radix Crepidis elongatae: base is former: be the root of feverfew long shoot Radix Crepidis elongatae.Nature and flavor: warm in nature flat, sweet in the mouth.Function cures mainly: kidney-replenishing, replenishing QI and blood, strengthening the spleen and stomach.Control sexual neurasthenie, married woman's cold womb is infertile, and leucorrhea is leaked down, dizziness and tinnitus, nervous palpitation with a distress feeling, digestant for baby and malnutrition.
Herb Polygoni Chinensis: base is former: be the herb of polygonaceae plant Herb Polygoni Chinensis.Nature and flavor: acid is sweet, cool.Function cures mainly: clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Control and have loose bowels, dysentery, jaundice, wind heat pharynx pain, weak dizzy, summer non-acclimation in children, shies and jerks, women leucorrhea, carbuncle eczema, traumatic injury.
Herba Viviae Sativae: base is former: be the herb of leguminous plant Herba Viviae Sativae.Nature and flavor: Gan Xin, cold.Function cures mainly: clearing away heat-damp and promoting diuresis, and blood and dissolving stasis.To harness the Yellow River subcutaneous ulcer, edema, malaria, epistaxis, cardiopalmus, nocturnal emission, menoxenia.
Fructus osmanthi fragrantis (Osmanthus fragrans Lour.): base is former: be the dry fruit of Oleaceae plants sweet-scented osmanthus.Nature and flavor: sweet, pungent, warm in nature.Gui Jing: liver, stomach warp.Function cures mainly: warming middle-JIAO to promote flow of QI pain relieving.Main cold syndrome of the stomach pain, stomachache due to hyperactive liver-QI attacking the stomach.
Ramulus et Folium Phyllodii Pulchelli: base is former: be the aerial parts of leguminous plant board Qian Shu.Nature and flavor: lightly seasoned, bitter, property is put down, mild toxicity.Gui Jing: lung, spleen, Liver Channel.Function cures mainly: heat-clearing and toxic substances removing, expelling wind and promoting diuresis, promoting blood circulation and detumescence.Main cold, fever, laryngopharynx swelling and pain, ulcerative gingivitis, rheumatic arthralgia, edema, expands, hepatosplenomegaly, treating swelling and pain by traumatic injury, insect-bite.
Rhizoma Drynariae: base is former: be the rhizome of Plants of Polypodiaceae Mongolian oak Herba pteridii latiusculi, drynaria baronii Diels, Drynaria propinqua, precipice Rhizoma Zingiberis Recens, bright close net Herba pteridii latiusculi and Davalliaceae plant great Ye Rhizoma Drynariae, Rhizoma Drynariae etc.Nature and flavor: bitter, temperature.Gui Jing: return kidney, Liver Channel.Function cures mainly: the kidney invigorating bone strengthening, continues and hinders pain relieving.For lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone, external treatment alopecia areata, vitiligo.
Herba Ipomoeae Pes-Capraes: base is former: be the herb of convolvulaceous plant king crab rattan.Nature and flavor: arduous, are slightly cold.Gui Jing: enter liver, spleen two warp.Function cures mainly: dispel the wind, dehumidifying, eliminating carbuncle, eliminating stagnation.Dispelling the wind and dampness pathogens arthralgia pain, carbuncle, toxic swelling, treats skin ulcer, anal fistula.
Rhizoma woodwardiae: base is former: be rhizome and the petiole base of Blechnaceae plant Rhizoma Osmundae.Nature and flavor: cool in nature, bitter in the mouth.Function cures mainly: heat-clearing and toxic substances removing, parasite killing dissipating blood stasis.For flu, sore and toxic, abdominal pain due to worm stagnation, have blood in stool, metrorrhagia.
Anoectochilus nefiliforme (Nakai) hara: base is former: be the herb of orchid Anoectochilus Roxburghii and Anoectochilus nefiliforme (Nakai) hara.Nature and flavor: sweet are cool.Gui Jing: lung, liver, kidney, urinary bladder channel.Function cures mainly: clearing away heat and cooling blood, removing dampness and detoxicating.Main lung-heat hemoptysis, hemoptysis of pulmonary tuberculosis, hematuria, infantile convulsion, tetanus, oedema due to nephritis, rheumatic arthralgia, traumatic injury.
Rhizoma nupharis pumili: base is former: be the rhizome of nymphaeaceae plant spatterdock.Nature and flavor: sweet, cold.Function cures mainly: tonify deficiency, stomach invigorating, regulating menstruation.Weak after curing the disease, dyspepsia, menoxenia.
Fructus Schisandrae Chinensis: base is former: be the fruit of Drymotaenium miyoshianum (Mak.) Mak. kind of plant Fructus Schisandrae Chinensis.Nature and flavor: sour, sweet, temperature.Gui Jing: return lung, the heart, kidney channel.Function cures mainly: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Herba Leontopodii Leontopodioidis: base is former: be the herb of feverfew Leontopodium leontopodioides (Willd.) Beauv..Nature and flavor: micro-hardship, cold.Function cures mainly: clearing away heat and cooling blood, kidney tonifying diuretic.Control acute nephritis, hematuria.
test example 1the clinical practice of the prescription (embodiment 5) of gained treatment senile dementia of the present invention:
In May ,-2014 in March, 2012, filter out 244 routine old dementia patients in 5 Hospital Spirit internal medicine and Geriatrics Dept. outpatient service, wherein women 112 example, male 132 example, age 63-82 year, the mean age (70.6 ± 3.8) year, course of disease 0.5-5, average course of disease (2.2 ± 1.1) year.All experimenters all diagnose according to Chinese Spirit Obstacles classification and diagnostic criteria, all point out the atrophy of diffusivity Cerebral cortex through imaging examinations such as intracranial CT, MRI, with psychotic symptoms such as auditory hallucination, delusion of persecution, emotion and behavior disorders.
Patient is divided into two groups at random, experimental group 144 example and matched group 100 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (
p> 0.05), there is comparability.Experimental group takes products obtained therefrom of the present invention, and take every day twice (warm), each 350m1-400m1(adjusts to some extent depending on concrete condition), 30 days courses for the treatment of, treat three courses for the treatment of continuously.Matched group takes other medicine (conventional medication such as oxiracetam capsule, Huperzine-A Tablets, Tests for Uniformity, donepezil hydrochloride tablet).Treatments period carries out Continuous Observation to two groups of patients, and before recording all subject, rear Mini-mental Status Examination (MMSE) is marked and daily living measuring scale (ADL) scoring with treatment.
The comparison of MMSE and ADL before and after table 1 liang group patient treatment
As shown in Table 1: compared with before treatment, after treatment, experimental group patient MMSE and ADL score value all have significant change, difference has statistical significance (P < 0.05), and before and after treatment of control group MMSE and ADL score value without significant change (P > 0.05).Compare between two groups after treatment, experimental group MMSE score value is apparently higher than matched group, and difference has statistical significance (P < 0.05), experimental group ADL and matched group difference not obvious (P > 0.05).Obviously comparatively matched group is good for the improvement of illustrative experiment group cognitive function of patients, and behavioral competence improves with matched group difference not obvious.In therapeutic process, all there is not any untoward reaction phenomenon in two groups of patients.
The present invention selects ginseng qi-tonifying admittedly to take off, and Fructus Elaeagni is quenched one's thirst antidiarrheal, Radix Crepidis elongatae kidney-replenishing, Herb Polygoni Chinensis clearing away heat-damp and promoting diuresis, Herba Viviae Sativae and blood and dissolving stasis, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) warming middle-JIAO to promote flow of QI, Ramulus et Folium Phyllodii Pulchelli expelling wind and promoting diuresis, Rhizoma Drynariae the kidney invigorating bone strengthening, Herba Ipomoeae Pes-Capraes expelling wind and removing dampness, rhizoma woodwardiae heat-clearing and toxic substances removing, Anoectochilus nefiliforme (Nakai) hara removing dampness and detoxicating, the stomach invigorating of Rhizoma nupharis pumili tonify deficiency, Fructus Schisandrae Chinensis convergence is astringent or styptic treatment for spontaneous sweating, Herba Leontopodii Leontopodioidis clearing away heat and cooling blood, all medicines share, and can play the effects such as kidney tonifying bone strengthening, tranquilization and refreshment.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat the prescription of senile dementia, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Radix Ginseng 9-15, Fructus Elaeagni 7-13, Radix Crepidis elongatae 8-14, Herb Polygoni Chinensis 10-16, Herba Viviae Sativae 9-14, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 7-15, Ramulus et Folium Phyllodii Pulchelli 9-16, Rhizoma Drynariae 8-13, Herba Ipomoeae Pes-Capraes 10-14, rhizoma woodwardiae 9-13, Anoectochilus nefiliforme (Nakai) hara 7-14, Rhizoma nupharis pumili 11-15, Fructus Schisandrae Chinensis 10-13, Herba Leontopodii Leontopodioidis 9-12.
2. the prescription for the treatment of senile dementia as claimed in claim 1, it is characterized in that, Radix Ginseng 10-14, Fructus Elaeagni 9-11, Radix Crepidis elongatae 10-12, Herb Polygoni Chinensis 12-14, Herba Viviae Sativae 11-12, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 9-13, Ramulus et Folium Phyllodii Pulchelli 11-14, Rhizoma Drynariae 10-11, Herba Ipomoeae Pes-Capraes 11-13, rhizoma woodwardiae 10-12, Anoectochilus nefiliforme (Nakai) hara 9-12, Rhizoma nupharis pumili 12-14, Fructus Schisandrae Chinensis 11-12, Herba Leontopodii Leontopodioidis 10-11 is (preferred, Radix Ginseng 12, Fructus Elaeagni 10, Radix Crepidis elongatae 11, Herb Polygoni Chinensis 13, Herba Viviae Sativae 11.5, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 11, Ramulus et Folium Phyllodii Pulchelli 12.5, Rhizoma Drynariae 10.5, Herba Ipomoeae Pes-Capraes 12, rhizoma woodwardiae 11, Anoectochilus nefiliforme (Nakai) hara 10.5, Rhizoma nupharis pumili 13, Fructus Schisandrae Chinensis 11.5, Herba Leontopodii Leontopodioidis 10.5).
3. the prescription of the treatment senile dementia as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Radix Ginseng and Radix Crepidis elongatae to clean, section, add Radix Ginseng slice and Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat to stir-fry to surface in time yellow, takes out, dries in the air cool;
(2) get Herb Polygoni Chinensis, Herba Viviae Sativae, Ramulus et Folium Phyllodii Pulchelli, Herba Ipomoeae Pes-Capraes and Anoectochilus nefiliforme (Nakai) hara rice-washed water clean and infiltrate 20-30 minute (preferred, infiltrate 23-27 minute; Be more preferably, infiltrate 25 minutes), pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) Rhizoma nupharis pumili is scraped peeling, rice wine infiltrates 30 minutes, takes out, and after tight with toilet paper parcel, then uses salt water-soaked toilet paper, is placed in hot ash, simmer and become coke black to surperficial paper, take out, dry;
(4) Fructus Elaeagni, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, rhizoma woodwardiae, Fructus Schisandrae Chinensis and Herba Leontopodii Leontopodioidis are cleaned, soak 20 minutes, take out, decoct with water together with step (2) (3) made crude drug, big fire is boiled rear little fire and is decocted 33-45 minute (preferred, 36-42 minute decocted by little fire; Be more preferably, little fire decocts 39 minutes), filter, collect filtrate;
(5) step (1) made crude drug was pulverized 200 mesh sieves, made medicated powder, and joined in step (4) made filtrate, mix thoroughly, obtain decoction.
4. the preparation method of the prescription decoction for the treatment of senile dementia as claimed in claim 3, is characterized in that, step (4) decocts the 7-9 that institute's amount of water is boiled crude drug quality and doubly (preferably, decocts 8 times that institute's amount of water is boiled crude drug quality).
5. the prescription of the treatment senile dementia as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable soft extract, its preparation method is:
(1) get Radix Ginseng and Radix Crepidis elongatae to clean, section, add Radix Ginseng slice and Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat to stir-fry to surface in time yellow, takes out, dries in the air cool, pulverized 200 mesh sieves, obtained medicated powder;
(2) get Herb Polygoni Chinensis, Herba Viviae Sativae, Ramulus et Folium Phyllodii Pulchelli, Herba Ipomoeae Pes-Capraes and Anoectochilus nefiliforme (Nakai) hara rice-washed water clean and infiltrate 20-30 minute (preferred, infiltrate 23-27 minute; Be more preferably, infiltrate 25 minutes), pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) Rhizoma nupharis pumili is scraped peeling, rice wine infiltrates 30 minutes, takes out, and after tight with toilet paper parcel, then uses salt water-soaked toilet paper, is placed in hot ash, simmer and become coke black to surperficial paper, take out, dry;
(4) Fructus Elaeagni, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, rhizoma woodwardiae, Fructus Schisandrae Chinensis and Herba Leontopodii Leontopodioidis are cleaned, soak 20 minutes, take out, decoct with water together with step (2) (3) made crude drug, institute's amount of water is 8 times of boiled crude drug quality, and big fire is boiled rear little fire and decocted, and filters, filtering residue decocts with water again, merges twice and decocts medicinal liquid;
(5) step (4) made medicinal liquid is brewed into clear paste, constantly stirs, add step (1) made medicated powder and mix thoroughly, then add refined honey mixing, obtain soft extract.
6. the preparation method of the prescription soft extract for the treatment of senile dementia as claimed in claim 5, is characterized in that, step (4) big fire is boiled rear little fire and decocted 33-45 minute (preferred, 36-42 minute decocted by little fire; Be more preferably, little fire decocts 39 minutes).
7. the prescription of the treatment senile dementia as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) get Radix Ginseng and Radix Crepidis elongatae to clean, section, add Radix Ginseng slice and Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat to stir-fry to surface in time yellow, takes out, dries in the air cool;
(2) get Herb Polygoni Chinensis, Herba Viviae Sativae, Ramulus et Folium Phyllodii Pulchelli, Herba Ipomoeae Pes-Capraes and Anoectochilus nefiliforme (Nakai) hara rice-washed water clean and infiltrate 20-30 minute (preferred, infiltrate 23-27 minute; Be more preferably, infiltrate 25 minutes), pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) Rhizoma nupharis pumili is scraped peeling, rice wine infiltrates 30 minutes, takes out, and after tight with toilet paper parcel, then uses salt water-soaked toilet paper, is placed in hot ash, simmer and become coke black to surperficial paper, take out, dry;
(4) Fructus Elaeagni, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, rhizoma woodwardiae, Fructus Schisandrae Chinensis and Herba Leontopodii Leontopodioidis are cleaned, soak 20 minutes post-heating to decoct, institute's amount of water is 8 times of boiled crude drug quality, and big fire is boiled rear little fire and decocted 33-45 minute (preferred, 36-42 minute decocted by little fire; Be more preferably, little fire decocts 39 minutes), filter, filtering residue decocts with water again, merges twice and decocts medicinal liquid, and spraying dry, pulverize and make dry thing powder;
(5) step (1) (2) (3) made crude drug is pulverized and sieved together, make medicated powder and mix with the made dry thing powder of step (4), mixed medicated powder is pressed into circular or other forms of tablet dosage form according to the preparation for processing of tablet, obtains tablet.
8. the preparation method of the prescription tablet for the treatment of senile dementia as claimed in claim 7, is characterized in that, the dosage of medicated powder contained by the every sheet of step (5) is 0.25-0.35g/ sheet (preferred, contained by every sheet, the dosage of medicated powder is 0.30g/ sheet).
9. the prescription of the treatment senile dementia as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable electuary, its preparation method is:
(1) get Radix Ginseng and Radix Crepidis elongatae to clean, section, add Radix Ginseng slice and Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat to stir-fry to surface in time yellow, takes out, dries in the air cool, pulverized 200 mesh sieves, obtained medicated powder;
(2) get Herb Polygoni Chinensis, Herba Viviae Sativae, Ramulus et Folium Phyllodii Pulchelli, Herba Ipomoeae Pes-Capraes and Anoectochilus nefiliforme (Nakai) hara rice-washed water clean and infiltrate 20-30 minute (preferred, infiltrate 23-27 minute; Be more preferably, infiltrate 25 minutes), pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) Rhizoma nupharis pumili is scraped peeling, rice wine infiltrates 30 minutes, takes out, and after tight with toilet paper parcel, then uses salt water-soaked toilet paper, is placed in hot ash, simmer and become coke black to surperficial paper, take out, dry;
(4) Fructus Elaeagni, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, rhizoma woodwardiae, Fructus Schisandrae Chinensis and Herba Leontopodii Leontopodioidis are cleaned, soak 20 minutes, take out, decoct with water together with step (2) (3) made crude drug, amount of water is 8 times of boiled crude drug quality, big fire is boiled rear little fire and is decocted 33-45 minute (preferred, 36-42 minute decocted by little fire; Be more preferably, little fire decocts 39 minutes), filter, filtering residue decocts with water again, merges twice and decocts medicinal liquid;
(5) step (4) made medicine liquid spray be dry, pulverize into medicated powder, add step (1) made medicated powder and mix thoroughly, obtain electuary.
10. the preparation method of the prescription electuary for the treatment of senile dementia as claimed in claim 9, is characterized in that, step (5) pulverized 200-300 mesh sieve (preferred, to pulverize 260 mesh sieves).
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| WO2018080158A1 (en) * | 2016-10-25 | 2018-05-03 | 한국 한의학 연구원 | Composition for preventing, improving or treating cognitive impairment, containing elaeagnus glabra extract as active ingredient |
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| WO2018080158A1 (en) * | 2016-10-25 | 2018-05-03 | 한국 한의학 연구원 | Composition for preventing, improving or treating cognitive impairment, containing elaeagnus glabra extract as active ingredient |
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Application publication date: 20151216 |