CN105148073A - Chinese herb composition for treating senile dementia and preparation method - Google Patents
Chinese herb composition for treating senile dementia and preparation method Download PDFInfo
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Abstract
The invention discloses a Chinese herb composition for treating senile dementia. The Chinese herb composition is mainly prepared from, by mass, 9-16 parts of schisandra chinensis, 7-13 parts of anoectochilus roxburghii, 8-14 parts of rhizoma woodwardiae, 10-15 parts of sweet osmanthus fruits, 9-14 parts of vicia gigantean, 11-16 parts of glossy privet fruits, 8-13 parts of crepis rigescens, 6-15 parts of Ilex cornuta fruits, 9-13 parts of Ipomoea pescaprae, 7-14 parts of motherwort fruits, 9-15 parts of davallia mariesii, 6-13 parts of elaeagnus pungens, 8-15 parts of old rice and 9-12 parts of persicaria chinensis. The Chinese herb composition is prepared from the Chinese herb plant materials, and is high in safety and free of any toxic and side effects; the composite is formed based on the Chinese medicine rule in a developed mode, has the functions of warming the middle, tonifying the kidneys, benefiting qi for activating blood circulation, refreshing for enlightening and others, is good in treatment effect, free of adverse effects, low in cost and easy to accept by patients, and reduces ecnomical burdens for the patients.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine composition and the method for making of curing senile dementia.
Background technology
Alzheimer, be alzheimer disease again, it is a kind of PDCD occurring in Senectitude and presenium, refer to a kind of persistence higher nerve functional activity obstacle, namely under the state not having disturbance of consciousness, memory, thinking, analysis judge, the obstacle of the aspects such as visual space identification, emotion.Main manifestations is the neuropsychic symptoms such as gradual memory obstacle, cognitive dysfunction, personality changes and aphasis, has a strong impact on social activity, occupation and vital function.Its characteristic pathological is changed to atrophy of cerebral cortex, and with amyloid-beta deposition, neurofibrillary tangles, mass memory neuron number reduces, and the formation of senile plaque.This sick insidious onset, spirit changes concealment, and be difficult to be aware in early days, classical symptom has activity of daily living to go down and dystropy, and recent amnesia phenomenon is One's eyesight is restrained, forgetful, cognitive dysfunction and memory disorder.Because the cause of disease of AD and pathogenesis are not yet clear and definite, treatment there is no specific short, can only based on symptomatic treatment.Comprise Drug therapy and improve cognitive function and dysmnesia, symptomatic treatment improves mental symptom, and good nursing delays disease progression.Medicine and rehabilitation, to improve cognition and memory function, keep the independent living ability of patient, improve for the purpose of life quality.
Publication No. CN104784353A(application number 201510211612.X) Chinese patent literature disclose a kind of Chinese medicine for the treatment of senile dementia, comprise Semen Persicae 10-20, Radix Et Rhizoma Rhei 10-15, Ramulus Cinnamomi 8-12, Os Draconis 5-8, Concha Ostreae 5-10, Poria 6-9, Radix Polygalae 8-12, Scolopendra 10-15, Rhizoma Cimicifugae 6-9, Lignum Aquilariae Resinatum 3-5, Rhizoma Atractylodis Macrocephalae 6-10, Radix Glycyrrhizae 5-10.Publication No. CN104667119A(application number 201310642291.X) Chinese patent literature disclose a kind of medicine for the treatment of senile dementia, by Fructus Alpiniae Oxyphyllae 10-15 part, Semen Juglandis 10-15 part, Herba Artemisiae Scopariae 3-9 part, Fructus rosae multiflorae 3-9 part, Pheretima charcoal 3-9 part, Rhizoma Menispermi 2-7 part, Fructus Amomi Rotundus 2-7 part, Lignum Pini Nodi 2-7 part, Flos Sophorae 2-7 part, hair Rhizoma Zingiberis Recens 2-7 part and honey are made for ball.Publication No. CN103446317A(application number 201210172975.3) Chinese patent literature disclose a kind of Chinese medicine for the treatment of senile dementia, consist of Flos Rosae Rugosae 8 parts, Pericarpium Citri Reticulatae 8 parts, Radix Et Rhizoma Rhei 8 parts, Flos Celosiae Cristatae 15 parts, Fructus Aurantii Immaturus 15 parts, the Radix Angelicae Dahuricae 8 parts, 8 parts, Semen Persicae, the Radix Aucklandiae 15 parts, Herba Eupatorii 15 parts.
Long-term taking Western medicine, curative effect is very micro-, and easily produces dependency, and side effect is obvious, and Chinese native medicine security is high, easy long-term taking, stable curative effect, therefore can develop a kind of good effect according to determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs principle, the Chinese medicine preparation of the treatment senile dementia that safety is high.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide Chinese medicine composition and the method for making of a kind of good effect, easily the treatment senile dementia of clothes of a specified duration.
Technical scheme of the present invention is:
Cure a Chinese medicine composition for senile dementia, be prepared from primarily of following bulk drugs, be mass parts: Fructus Schisandrae Chinensis 9-16, Anoectochilus nefiliforme (Nakai) hara 7-13, rhizoma woodwardiae 8-14, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 10-15, Herba Viviae Sativae 9-14, Fructus Ligustri Lucidi 11-16, Radix Crepidis elongatae 8-13, Fructus Ilicis Cornutae 6-15, Herba Ipomoeae Pes-Capraes 9-13, Fructus Leonuri 7-14, Rhizoma Drynariae 9-15, Fructus Elaeagni 6-13, Oryza sativa L. 8-15, Herb Polygoni Chinensis 9-12.
In preferred scheme, Fructus Schisandrae Chinensis 10-15, Anoectochilus nefiliforme (Nakai) hara 9-11, rhizoma woodwardiae 10-12, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 11-14, Herba Viviae Sativae 10-13, Fructus Ligustri Lucidi 12-15, Radix Crepidis elongatae 9-12, Fructus Ilicis Cornutae 8-13, Herba Ipomoeae Pes-Capraes 10-12, Fructus Leonuri 9-12, Rhizoma Drynariae 10-14, Fructus Elaeagni 8-11, Oryza sativa L. 10-13, Herb Polygoni Chinensis 10-11.
Be more preferably, Fructus Schisandrae Chinensis 12.5, Anoectochilus nefiliforme (Nakai) hara 10, rhizoma woodwardiae 11, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 12.5, Herba Viviae Sativae 11.5, Fructus Ligustri Lucidi 13.5, Radix Crepidis elongatae 10.5, Fructus Ilicis Cornutae 10.5, Herba Ipomoeae Pes-Capraes 11, Fructus Leonuri 10.5, Rhizoma Drynariae 12, Fructus Elaeagni 9.5, Oryza sativa L. 11.5, Herb Polygoni Chinensis 10.5.
Described a kind of Chinese medicine composition of curing senile dementia, be made into pharmaceutically acceptable powder, its preparation method is:
(1) Fructus Ligustri Lucidi, Fructus Ilicis Cornutae and Fructus Leonuri roguing are cleaned, add yellow wine and water, with Semen sojae atricolor with boiling, after well-done, taking out, being placed in frying pan, frying to dry tack free, take out, smash to pieces, dry;
(2) get Anoectochilus nefiliforme (Nakai) hara, Herba Viviae Sativae, Herba Ipomoeae Pes-Capraes and Herb Polygoni Chinensis rice-washed water clean and infiltrate 20-30 minute (preferred, infiltrate 23-27 minute; Be more preferably, infiltrate 25 minutes), pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) get Radix Crepidis elongatae clean, section, add Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat stir-fries to surface in time yellow, and taking-up, dries in the air cool;
(4) Fructus Schisandrae Chinensis, rhizoma woodwardiae, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, Fructus Elaeagni and Oryza sativa L. are cleaned, Steam by water bath is saturating, takes out, and dries, pulverizes and sieves, obtain powder together with step (1) (2) (3) made crude drug.
Described a kind of preparation method curing the Chinese medicine composition composition powders of senile dementia, step (4) was pulverized 120-260 mesh sieve and (preferably, was pulverized 140-240 mesh sieve; Be more preferably, pulverized 190 mesh sieves).
Described a kind of Chinese medicine composition of curing senile dementia, be made into pharmaceutically acceptable pill, its preparation method is:
(1) Fructus Ligustri Lucidi, Fructus Ilicis Cornutae and Fructus Leonuri roguing are cleaned, add yellow wine and water, with Semen sojae atricolor with boiling, after well-done, taking out, being placed in frying pan, frying to dry tack free, take out, smash to pieces, dry;
(2) get Anoectochilus nefiliforme (Nakai) hara, Herba Viviae Sativae, Herba Ipomoeae Pes-Capraes and Herb Polygoni Chinensis rice-washed water clean and infiltrate, pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) get Radix Crepidis elongatae clean, section, add Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat stir-fries to surface in time yellow, and taking-up, dries in the air cool;
(4) Fructus Schisandrae Chinensis, rhizoma woodwardiae, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, Fructus Elaeagni and Oryza sativa L. are cleaned, Steam by water bath is saturating, takes out, and dries, and pulverized 100-160 mesh sieve and (preferably, pulverized 120-140 mesh sieve together with step (1) (2) (3) made crude drug; Be more preferably, pulverized 130 mesh sieves), make medicated powder, add that refined honey water is general makes ball, obtain pill.
Described a kind of preparation method curing the Chinese medicine composition pill of senile dementia, step (2) infiltrates 20-30 minute and (preferably, infiltrates 23-27 minute; Be more preferably, infiltrate 25 minutes).
Described a kind of Chinese medicine composition of curing senile dementia, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) Fructus Ligustri Lucidi, Fructus Ilicis Cornutae and Fructus Leonuri roguing are cleaned, add yellow wine and water, with Semen sojae atricolor with boiling, after well-done, taking out, being placed in frying pan, frying to dry tack free, take out, smash to pieces, dry;
(2) get Anoectochilus nefiliforme (Nakai) hara, Herba Viviae Sativae, Herba Ipomoeae Pes-Capraes and Herb Polygoni Chinensis rice-washed water clean and infiltrate 20-30 minute (preferred, infiltrate 23-27 minute; Be more preferably, infiltrate 25 minutes), pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) get Radix Crepidis elongatae clean, section, add Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat stir-fries to surface in time yellow, and taking-up, dries in the air cool;
(4) Fructus Schisandrae Chinensis, rhizoma woodwardiae, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, Fructus Elaeagni and Oryza sativa L. are cleaned, decoct with water together with step (1) (2) made crude drug, the 7-8 that amount of water is boiled crude drug quality is doubly (preferred, amount of water is 7.5 times of boiled crude drug quality), decoct twice, filter, collect medicinal liquid, merge twice filtrate;
(5) medicated powder is made in made for step (3) crude drug pulverizing, join in step (4) made filtrate, stir evenly, obtain decoction.
Described a kind of preparation method curing the Chinese medicine composition decoction of senile dementia, step (4) decoct at every turn for big fire boil 10-20 minute after turn a little fire decoct 20 minutes (preferred, each decoct for big fire boil 15 minutes after a turn little fire decoct 20 minutes).
Described a kind of Chinese medicine composition of curing senile dementia, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) Fructus Ligustri Lucidi, Fructus Ilicis Cornutae and Fructus Leonuri roguing are cleaned, add yellow wine and water, with Semen sojae atricolor with boiling, after well-done, taking out, being placed in frying pan, frying to dry tack free, take out, smash to pieces, dry;
(2) get Anoectochilus nefiliforme (Nakai) hara, Herba Viviae Sativae, Herba Ipomoeae Pes-Capraes and Herb Polygoni Chinensis rice-washed water clean and infiltrate 20-30 minute (preferred, infiltrate 23-27 minute; Be more preferably, infiltrate 25 minutes), pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) get Radix Crepidis elongatae clean, section, add Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat stir-fries to surface in time yellow, and taking-up, dries in the air cool;
(4) Fructus Schisandrae Chinensis, rhizoma woodwardiae, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, Fructus Elaeagni and Oryza sativa L. are cleaned, decoct with water together with step (1) (2) made crude drug, decoct twice, each decoct for big fire boil 10-20 minute after turn a little fire and decoct 20 minutes (preferably, each decoction is turn little fire after big fire boils 15 minutes to decoct 20 minutes), filter, collect filtrate, merge twice filtrate, concentrated, dry, pulverize, obtained xeraphium;
(5) medicated powder is made in made for step (3) crude drug pulverizing, mix with step (4) made xeraphium, add auxiliary materials and mixing, be processed into tablet dosage form according to the preparation for processing of tablet, obtain tablet.
Described a kind of preparation method curing the Chinese medicine composition tablet of senile dementia, the 7-9 that step (4) amount of water is boiled crude drug quality is (preferred, amount of water is 8 times of boiled crude drug quality) doubly.
A kind of Chinese medicine composition of curing senile dementia provided by the invention is prepared simple, scientific formula, product taking convenience.In addition, excellent results of the present invention also shows:
1, the present invention is made up of Chinese medicinal plant material, and safety is high, without any side effects;
2, this prescription develops according to Chinese medicine principle, has the effects such as warming middle-JIAO the kidney invigorating, benefiting QI for activating blood circulation, consciousness-restoring and orifice-opening;
3, good effect of the present invention, has no adverse reaction, and cost is low, and financial burden is little, and patient easily accepts.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Fructus Schisandrae Chinensis: base is former: be the fruit of Drymotaenium miyoshianum (Mak.) Mak. kind of plant Fructus Schisandrae Chinensis.Nature and flavor: sour, sweet, temperature.Gui Jing: return lung, the heart, kidney channel.Function cures mainly: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Anoectochilus nefiliforme (Nakai) hara: base is former: be the herb of orchid Anoectochilus Roxburghii and Anoectochilus nefiliforme (Nakai) hara.Nature and flavor: sweet are cool.Gui Jing: lung, liver, kidney, urinary bladder channel.Function cures mainly: clearing away heat and cooling blood, removing dampness and detoxicating.Main lung-heat hemoptysis, hemoptysis of pulmonary tuberculosis, hematuria, infantile convulsion, tetanus, oedema due to nephritis, rheumatic arthralgia, traumatic injury.
Rhizoma woodwardiae: base is former: be rhizome and the petiole base of Blechnaceae plant Rhizoma Osmundae.Nature and flavor: cool in nature, bitter in the mouth.Function cures mainly: heat-clearing and toxic substances removing, parasite killing dissipating blood stasis.For flu, sore and toxic, abdominal pain due to worm stagnation, have blood in stool, metrorrhagia.
Fructus osmanthi fragrantis (Osmanthus fragrans Lour.): base is former: be the dry fruit of Oleaceae plants sweet-scented osmanthus.Nature and flavor: sweet, pungent, warm in nature.Gui Jing: liver, stomach warp.Function cures mainly: warming middle-JIAO to promote flow of QI pain relieving.Main cold syndrome of the stomach pain, stomachache due to hyperactive liver-QI attacking the stomach.
Herba Viviae Sativae: base is former: be the herb of leguminous plant Herba Viviae Sativae.Nature and flavor: Gan Xin, cold.Function cures mainly: clearing away heat-damp and promoting diuresis, and blood and dissolving stasis.To harness the Yellow River subcutaneous ulcer, edema, malaria, epistaxis, cardiopalmus, nocturnal emission, menoxenia.
Fructus Ligustri Lucidi: base is former: be the fruit of Oleaceae plants Fructus Ligustri Lucidi.Nature and flavor: sweet, bitter, cold.Gui Jing: return liver, kidney channel.Function cures mainly: nourishing the liver and kidney, improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision.
Radix Crepidis elongatae: base is former: be the root of feverfew long shoot Radix Crepidis elongatae.Nature and flavor: warm in nature flat, sweet in the mouth.Function cures mainly: kidney-replenishing, replenishing QI and blood, strengthening the spleen and stomach.Control sexual neurasthenie, married woman's cold womb is infertile, and leucorrhea is leaked down, dizziness and tinnitus, nervous palpitation with a distress feeling, digestant for baby and malnutrition.
Fructus Ilicis Cornutae: base is former: be the fruit of holly plant Ilex cornuta Lindl..Nature and flavor: bitter, puckery, tepor.Function cures mainly: the astringent or styptic treatment for spontaneous sweating part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels.For leukorrhagia, chronic diarrhea.
Herba Ipomoeae Pes-Capraes: base is former: be the herb of convolvulaceous plant king crab rattan.Nature and flavor: arduous, are slightly cold.Gui Jing: enter liver, spleen two warp.Function cures mainly: dispel the wind, dehumidifying, eliminating carbuncle, eliminating stagnation.Dispelling the wind and dampness pathogens arthralgia pain, carbuncle, toxic swelling, treats skin ulcer, anal fistula.
Fructus Leonuri: base is former: be the fruit of labiate Herba Leonuri.Nature and flavor: pungent, bitter, are slightly cold.Gui Jing: GUIXIN bag, Liver Channel.Function cures mainly: promoting blood flow to regulate menstruation, liver heat removing and eyesight improving.For menoxenia, amenorrhea, dysmenorrhea, cataract, dizzy distending pain.
Rhizoma Drynariae: base is former: be the rhizome of Plants of Polypodiaceae Mongolian oak Herba pteridii latiusculi, drynaria baronii Diels, Drynaria propinqua, precipice Rhizoma Zingiberis Recens, bright close net Herba pteridii latiusculi and Davalliaceae plant great Ye Rhizoma Drynariae, Rhizoma Drynariae etc.Nature and flavor: bitter, temperature.Gui Jing: return kidney, Liver Channel.Function cures mainly: the kidney invigorating bone strengthening, continues and hinders pain relieving.For lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone, external treatment alopecia areata, vitiligo.
Fructus Elaeagni: base is former: be the fruit of Elaeangnaceae plant Fructus Elaeagni.Nature and flavor: acid is wet are flat.Function cures mainly: control dysentery, quenches one's thirst, and breathes with cough.
Oryza sativa L.: base is former: be the Semen oryzae sativae that storage year is of a specified duration.Nature and flavor: sweet light are flat.Gui Jing: enter stomach, double enter the heart, spleen.Function cures mainly: nourishing the stomach, eliminating dampness by diuresis, relieving restlessness.Weakness of the spleen and stomach after curing the disease, excessive thirst, has loose bowels, regurgitation, fasting dysentery.
Herb Polygoni Chinensis: base is former: be the herb of polygonaceae plant Herb Polygoni Chinensis.Nature and flavor: acid is sweet, cool.Function cures mainly: clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Control and have loose bowels, dysentery, jaundice, wind heat pharynx pain, weak dizzy, summer non-acclimation in children, shies and jerks, women leucorrhea, carbuncle eczema, traumatic injury.
embodiment 1cure a Chinese medicine composition for senile dementia, be prepared from (every part of 10g) primarily of following bulk drugs: Fructus Schisandrae Chinensis 9 parts, Anoectochilus nefiliforme (Nakai) hara 7 parts, rhizoma woodwardiae 8 parts, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 10 parts, Herba Viviae Sativae 9 parts, Fructus Ligustri Lucidi 11 parts, Radix Crepidis elongatae 8 parts, Fructus Ilicis Cornutae 6 parts, Herba Ipomoeae Pes-Capraes 9 parts, Fructus Leonuri 7 parts, Rhizoma Drynariae 9 parts, Fructus Elaeagni 6 parts, Oryza sativa L. 8 parts, Herb Polygoni Chinensis 9 parts.
Above-mentioned a kind of preparation method curing the Chinese medicine composition composition powders of senile dementia is:
(1) Fructus Ligustri Lucidi, Fructus Ilicis Cornutae and Fructus Leonuri roguing are cleaned, add yellow wine and water, with Semen sojae atricolor with boiling, after well-done, taking out, being placed in frying pan, frying to dry tack free, take out, smash to pieces, dry;
(2) get Anoectochilus nefiliforme (Nakai) hara, Herba Viviae Sativae, Herba Ipomoeae Pes-Capraes and Herb Polygoni Chinensis rice-washed water clean and infiltrate 25 minutes, pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) get Radix Crepidis elongatae clean, section, add Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat stir-fries to surface in time yellow, and taking-up, dries in the air cool;
(4) Fructus Schisandrae Chinensis, rhizoma woodwardiae, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, Fructus Elaeagni and Oryza sativa L. are cleaned, Steam by water bath is saturating, takes out, and dries, pulverizes 190 mesh sieves, and obtained powder together with step (1) (2) (3) made crude drug.
embodiment 2cure a Chinese medicine composition for senile dementia, be prepared from (every part of 10g) primarily of following bulk drugs: Fructus Schisandrae Chinensis 16 parts, Anoectochilus nefiliforme (Nakai) hara 13 parts, rhizoma woodwardiae 14 parts, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 15 parts, Herba Viviae Sativae 14 parts, Fructus Ligustri Lucidi 16 parts, Radix Crepidis elongatae 13 parts, Fructus Ilicis Cornutae 15 parts, Herba Ipomoeae Pes-Capraes 13 parts, Fructus Leonuri 14 parts, Rhizoma Drynariae 15 parts, Fructus Elaeagni 13 parts, Oryza sativa L. 15 parts, Herb Polygoni Chinensis 12 parts.
A kind of preparation method curing the Chinese medicine composition pill of senile dementia is:
(1) Fructus Ligustri Lucidi, Fructus Ilicis Cornutae and Fructus Leonuri roguing are cleaned, add yellow wine and water, with Semen sojae atricolor with boiling, after well-done, taking out, being placed in frying pan, frying to dry tack free, take out, smash to pieces, dry;
(2) get Anoectochilus nefiliforme (Nakai) hara, Herba Viviae Sativae, Herba Ipomoeae Pes-Capraes and Herb Polygoni Chinensis rice-washed water clean and infiltrate 25 minutes, pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) get Radix Crepidis elongatae clean, section, add Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat stir-fries to surface in time yellow, and taking-up, dries in the air cool;
(4) Fructus Schisandrae Chinensis, rhizoma woodwardiae, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, Fructus Elaeagni and Oryza sativa L. are cleaned, Steam by water bath is saturating, takes out, dry, pulverized 130 mesh sieves together with step (1) (2) (3) made crude drug, make medicated powder, add that refined honey water is general makes ball, obtain pill.
Model case: xxx, man, 74 years old.There is hypomnesis without obvious inducement before 2 years, with computing capability decline, reaction and ability to act slow gradually, sometimes be not even familiar with the road of going home, examination in hospital, CT points out multiple cerebral infarction, hospitalization, symptom goes home after taking a turn for the better to recuperate, and occurs murmuring to oneself after half a year, easily restless, misdraw clothes, be not familiar with the symptoms such as household, be hospitalized for treatment, be diagnosed as senile dementia, through being hospitalized for treatment, symptom does not take a turn for the better, and turns to remedy of TCM.
Take a kind of Chinese medicine composition pill of curing senile dementia of the present embodiment gained, every day 2 times, each 2-3 grain, warm water delivery service, 30 days courses for the treatment of.After taking a course for the treatment of, patient's memory is recovered to some extent, and emotion takes a turn for the better, without murmuring to oneself, but time and clear-headed time and muddled, after taking two courses for the treatment of, patient's memory significantly improves, understanding household, life can be taken care of oneself, after taking three courses for the treatment of substantially, minimal invasive treatment can take care of oneself completely, clinical recovery, consolidates and takes drug withdrawal after a course for the treatment of, follow up a case by regular visits to and do not recur after 1 year.
embodiment 3cure a Chinese medicine composition for senile dementia, be prepared from (every part of 10g) primarily of following bulk drugs: Fructus Schisandrae Chinensis 10 parts, Anoectochilus nefiliforme (Nakai) hara 9 parts, rhizoma woodwardiae 10 parts, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 11 parts, Herba Viviae Sativae 10 parts, Fructus Ligustri Lucidi 12 parts, Radix Crepidis elongatae 9 parts, Fructus Ilicis Cornutae 8 parts, Herba Ipomoeae Pes-Capraes 10 parts, Fructus Leonuri 9 parts, Rhizoma Drynariae 10 parts, Fructus Elaeagni 8 parts, Oryza sativa L. 10 parts, Herb Polygoni Chinensis 10 parts.
A kind of preparation method curing the Chinese medicine composition decoction of senile dementia is:
(1) Fructus Ligustri Lucidi, Fructus Ilicis Cornutae and Fructus Leonuri roguing are cleaned, add yellow wine and water, with Semen sojae atricolor with boiling, after well-done, taking out, being placed in frying pan, frying to dry tack free, take out, smash to pieces, dry;
(2) get Anoectochilus nefiliforme (Nakai) hara, Herba Viviae Sativae, Herba Ipomoeae Pes-Capraes and Herb Polygoni Chinensis rice-washed water clean and infiltrate 25 minutes, pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) get Radix Crepidis elongatae clean, section, add Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat stir-fries to surface in time yellow, and taking-up, dries in the air cool;
(4) Fructus Schisandrae Chinensis, rhizoma woodwardiae, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, Fructus Elaeagni and Oryza sativa L. are cleaned, decoct with water together with step (1) (2) made crude drug, amount of water is 7.5 times of boiled crude drug quality, each decoction is turn little fire after big fire boils 15 minutes to decoct 20 minutes, decoct twice, filter, collect medicinal liquid, merge twice filtrate;
(5) medicated powder is made in made for step (3) crude drug pulverizing, join in step (4) made filtrate, stir evenly, obtain decoction.
Model case: xxx, man, 68 years old.Hypomnesis was shown before 5 years, forgetful, go to the wrong way door,, there is bradykinesia in rear exacerbation of symptoms, verbigeration, murmur to oneself, dystropy, anxious state of mind is larger, be not familiar with relatives, examination in hospital, memory judgment, computing power and viability obviously go down, and are diagnosed as senile dementia, through medication treatment for many years, symptom is improved not obvious.
Take a kind of Chinese medicine composition decoction of curing senile dementia of the present embodiment gained, adopt every day 2 times (warm), each 300-400ml, 30 days courses for the treatment of.After taking two courses for the treatment of, patient mental takes a turn for the better, and emotion is day by day stablized, and memory is improved, remember part relatives name, after taking four courses for the treatment of, freely can exchange with people, the mental status is good, life can be taken care of oneself substantially, and patient fully recovers, and follow up a case by regular visits to after 1 year, patient body is in good condition.
embodiment 4cure a Chinese medicine composition for senile dementia, be prepared from (every part of 10g) primarily of following bulk drugs: Fructus Schisandrae Chinensis 15 parts, Anoectochilus nefiliforme (Nakai) hara 11 parts, rhizoma woodwardiae 12 parts, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 14 parts, Herba Viviae Sativae 13 parts, Fructus Ligustri Lucidi 15 parts, Radix Crepidis elongatae 12 parts, Fructus Ilicis Cornutae 13 parts, Herba Ipomoeae Pes-Capraes 12 parts, Fructus Leonuri 12 parts, Rhizoma Drynariae 14 parts, Fructus Elaeagni 11 parts, Oryza sativa L. 13 parts, Herb Polygoni Chinensis 11 parts.
A kind of preparation method curing the Chinese medicine composition tablet of senile dementia is:
(1) Fructus Ligustri Lucidi, Fructus Ilicis Cornutae and Fructus Leonuri roguing are cleaned, add yellow wine and water, with Semen sojae atricolor with boiling, after well-done, taking out, being placed in frying pan, frying to dry tack free, take out, smash to pieces, dry;
(2) get Anoectochilus nefiliforme (Nakai) hara, Herba Viviae Sativae, Herba Ipomoeae Pes-Capraes and Herb Polygoni Chinensis rice-washed water clean and infiltrate 25 minutes, pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) get Radix Crepidis elongatae clean, section, add Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat stir-fries to surface in time yellow, and taking-up, dries in the air cool;
(4) Fructus Schisandrae Chinensis, rhizoma woodwardiae, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, Fructus Elaeagni and Oryza sativa L. are cleaned, decoct with water together with step (1) (2) made crude drug, amount of water is 8 times of boiled crude drug quality, decocts twice, each decoction is turn little fire after big fire boils 15 minutes to decoct 20 minutes, filter, collect filtrate, merge twice filtrate, concentrated, dry, pulverize, obtained xeraphium;
(5) medicated powder is made in made for step (3) crude drug pulverizing, mix with step (4) made xeraphium, add auxiliary materials and mixing, be processed into tablet dosage form according to the preparation for processing of tablet, obtain tablet.
Model case: xxx, female, 76 years old.Nearly 1 year, anxious state of mind was comparatively large, dysphoria, and simultaneously with hypomnesis, bradykinesia, must not remember the road of going home, and dystropy, body and the spirit is dull, sleeps poor, and nocturnal pollakiuria, examination in hospital, is diagnosed as senile dementia.
Take a kind of Chinese medicine composition tablet of curing senile dementia of the present embodiment gained, adopt every day 2 times, each 4, with warm water delivery service, 30 days courses for the treatment of.After taking a course for the treatment of, memory significantly improves, and spirit takes a turn for the better, be emotionally stable, can better sleep in the evening, and frequent micturition is alleviated, after taking three courses for the treatment of, Patients ' Cognitive ability improves, and initiatively can exchange with household, after taking four courses for the treatment of, the all diseases of patient disappear entirely, and life can be taken care of oneself, and patient fully recovers, follow up a case by regular visits to after 1 year, do not recur.
embodiment 5cure a Chinese medicine composition for senile dementia, be prepared from (every part of 10g) primarily of following bulk drugs: Fructus Schisandrae Chinensis 12.5 parts, Anoectochilus nefiliforme (Nakai) hara 10 parts, rhizoma woodwardiae 11 parts, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 12.5 parts, Herba Viviae Sativae 11.5 parts, Fructus Ligustri Lucidi 13.5 parts, Radix Crepidis elongatae 10.5 parts, Fructus Ilicis Cornutae 10.5 parts, Herba Ipomoeae Pes-Capraes 11 parts, Fructus Leonuri 10.5 parts, Rhizoma Drynariae 12 parts, Fructus Elaeagni 9.5 parts, Oryza sativa L. 11.5 parts, Herb Polygoni Chinensis 10.5 parts.
A kind of preparation method curing the Chinese medicine composition composition powders of senile dementia is:
(1) Fructus Ligustri Lucidi, Fructus Ilicis Cornutae and Fructus Leonuri roguing are cleaned, add yellow wine and water, with Semen sojae atricolor with boiling, after well-done, taking out, being placed in frying pan, frying to dry tack free, take out, smash to pieces, dry;
(2) get Anoectochilus nefiliforme (Nakai) hara, Herba Viviae Sativae, Herba Ipomoeae Pes-Capraes and Herb Polygoni Chinensis rice-washed water clean and infiltrate 25 minutes, pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) get Radix Crepidis elongatae clean, section, add Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat stir-fries to surface in time yellow, and taking-up, dries in the air cool;
(4) Fructus Schisandrae Chinensis, rhizoma woodwardiae, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, Fructus Elaeagni and Oryza sativa L. are cleaned, Steam by water bath is saturating, takes out, and dries, pulverizes 190 mesh sieves, and obtained powder together with step (1) (2) (3) made crude drug.
test example 1a kind of clinical practice of curing the Chinese medicine composition (embodiment 5) of senile dementia of gained of the present invention:
In October ,-2014 in June, 2012, in the old dementia patients that 4 hospitals accept for medical treatment, filter out 210 routine patients, wherein women 98 example, male 112 example, age 58-80 year, the mean age (75.2 ± 3.5) year, course of disease 1-5, average course of disease (2.7 ± 0.8) year.Get rid of forget optimum old age, dementia that depression in old age, intracranial mass lesion, acute cerebral trauma and whole body system disease occur together.
Patient is divided into two groups at random, experimental group 120 example and matched group 90 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (
p> 0.05), there is comparability.Experimental group takes products obtained therefrom of the present invention, and every day takes twice, and each 3-5g(adjusts to some extent depending on concrete condition), 30 days courses for the treatment of, treat 3 courses for the treatment of continuously.Matched group takes other medicine as conventional medication such as Huperzine-A Tablets, Tests for Uniformity, Ginaton tablets, aniracetam granules.Treatments period carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect situation criterion: cure: cardinal symptom is recovered substantially, conscious, directed sound, answer a question correct, be quick on the draw, take care of oneself, can mass society activity be carried out; Effective: main spirits symptom weakens or partial disappearance to some extent, life is taken care of oneself substantially, answers a question and is in the main true, but bradykinesia, intelligence and personality still have partial impairment; Invalid: cardinal symptom has development without change or the state of an illness, can't take care of oneself, answers a question incorrect, mind moronism.
Table 1 liang group patient treatment outcome
As shown in Table 1, experimental group cures 31 examples, effective 84 examples, and the total effectively number of cases of experimental group is 115 examples, experimental group total effective rate is 95.8%, matched group cures 9 examples, effective 51 examples, and the total effectively number of cases of matched group is 60 examples, matched group total effective rate is 66.7%, two groups of therapeutic outcomes are compared known, and the therapeutic effect of experimental group is obviously better than matched group, and two groups of differences have statistical significance (P < 0.05).In therapeutic process, all there is not any untoward reaction phenomenon in two groups of patients.
The present invention selects the Fructus Schisandrae Chinensis having supplementing QI for promoting the production of body fluid, the Anoectochilus nefiliforme (Nakai) hara of clearing away heat and cooling blood, the rhizoma woodwardiae of heat-clearing and toxic substances removing, the Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) of warming middle-JIAO to promote flow of QI, the Herba Viviae Sativae of clearing away heat-damp and promoting diuresis, the Fructus Ligustri Lucidi of nourishing the liver and kidney, the Radix Crepidis elongatae of kidney-replenishing, the Fructus Ilicis Cornutae of the astringent or styptic treatment for spontaneous sweating part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, the Herba Ipomoeae Pes-Capraes of expelling wind and removing dampness, the Fructus Leonuri of promoting blood flow to regulate menstruation, the Rhizoma Drynariae of the kidney invigorating bone strengthening, the Fructus Elaeagni of antidiarrheal of quenching one's thirst, the Oryza sativa L. of nourishing the stomach eliminating dampness by diuresis, the Herb Polygoni Chinensis of clearing away heat-damp and promoting diuresis, all medicines share, and can play the effects such as warming middle-JIAO the kidney invigorating, benefiting QI for activating blood circulation, consciousness-restoring and orifice-opening.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. cure a Chinese medicine composition for senile dementia, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Fructus Schisandrae Chinensis 9-16, Anoectochilus nefiliforme (Nakai) hara 7-13, rhizoma woodwardiae 8-14, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 10-15, Herba Viviae Sativae 9-14, Fructus Ligustri Lucidi 11-16, Radix Crepidis elongatae 8-13, Fructus Ilicis Cornutae 6-15, Herba Ipomoeae Pes-Capraes 9-13, Fructus Leonuri 7-14, Rhizoma Drynariae 9-15, Fructus Elaeagni 6-13, Oryza sativa L. 8-15, Herb Polygoni Chinensis 9-12.
2. a kind of Chinese medicine composition of curing senile dementia as claimed in claim 1, it is characterized in that, Fructus Schisandrae Chinensis 10-15, Anoectochilus nefiliforme (Nakai) hara 9-11, rhizoma woodwardiae 10-12, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 11-14, Herba Viviae Sativae 10-13, Fructus Ligustri Lucidi 12-15, Radix Crepidis elongatae 9-12, Fructus Ilicis Cornutae 8-13, Herba Ipomoeae Pes-Capraes 10-12, Fructus Leonuri 9-12, Rhizoma Drynariae 10-14, Fructus Elaeagni 8-11, Oryza sativa L. 10-13, Herb Polygoni Chinensis 10-11 is (preferred, Fructus Schisandrae Chinensis 12.5, Anoectochilus nefiliforme (Nakai) hara 10, rhizoma woodwardiae 11, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.) 12.5, Herba Viviae Sativae 11.5, Fructus Ligustri Lucidi 13.5, Radix Crepidis elongatae 10.5, Fructus Ilicis Cornutae 10.5, Herba Ipomoeae Pes-Capraes 11, Fructus Leonuri 10.5, Rhizoma Drynariae 12, Fructus Elaeagni 9.5, Oryza sativa L. 11.5, Herb Polygoni Chinensis 10.5).
3. a kind of Chinese medicine composition of curing senile dementia as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable powder, its preparation method is:
(1) Fructus Ligustri Lucidi, Fructus Ilicis Cornutae and Fructus Leonuri roguing are cleaned, add yellow wine and water, with Semen sojae atricolor with boiling, after well-done, taking out, being placed in frying pan, frying to dry tack free, take out, smash to pieces, dry;
(2) get Anoectochilus nefiliforme (Nakai) hara, Herba Viviae Sativae, Herba Ipomoeae Pes-Capraes and Herb Polygoni Chinensis rice-washed water clean and infiltrate 20-30 minute (preferred, infiltrate 23-27 minute; Be more preferably, infiltrate 25 minutes), pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) get Radix Crepidis elongatae clean, section, add Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat stir-fries to surface in time yellow, and taking-up, dries in the air cool;
(4) Fructus Schisandrae Chinensis, rhizoma woodwardiae, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, Fructus Elaeagni and Oryza sativa L. are cleaned, Steam by water bath is saturating, takes out, and dries, pulverizes and sieves, obtain powder together with step (1) (2) (3) made crude drug.
4. a kind of preparation method curing the Chinese medicine composition composition powders of senile dementia as claimed in claim 3, is characterized in that, step (4) was pulverized 120-260 mesh sieve and (preferably, pulverized 140-240 mesh sieve; Be more preferably, pulverized 190 mesh sieves).
5. a kind of Chinese medicine composition of curing senile dementia as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable pill, its preparation method is:
(1) Fructus Ligustri Lucidi, Fructus Ilicis Cornutae and Fructus Leonuri roguing are cleaned, add yellow wine and water, with Semen sojae atricolor with boiling, after well-done, taking out, being placed in frying pan, frying to dry tack free, take out, smash to pieces, dry;
(2) get Anoectochilus nefiliforme (Nakai) hara, Herba Viviae Sativae, Herba Ipomoeae Pes-Capraes and Herb Polygoni Chinensis rice-washed water clean and infiltrate, pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) get Radix Crepidis elongatae clean, section, add Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat stir-fries to surface in time yellow, and taking-up, dries in the air cool;
(4) Fructus Schisandrae Chinensis, rhizoma woodwardiae, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, Fructus Elaeagni and Oryza sativa L. are cleaned, Steam by water bath is saturating, takes out, and dries, and pulverized 100-160 mesh sieve and (preferably, pulverized 120-140 mesh sieve together with step (1) (2) (3) made crude drug; Be more preferably, pulverized 130 mesh sieves), make medicated powder, add that refined honey water is general makes ball, obtain pill.
6. a kind of preparation method curing the Chinese medicine composition pill of senile dementia as claimed in claim 5, is characterized in that, step (2) infiltrates 20-30 minute and (preferably, infiltrates 23-27 minute; Be more preferably, infiltrate 25 minutes).
7. a kind of Chinese medicine composition of curing senile dementia as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) Fructus Ligustri Lucidi, Fructus Ilicis Cornutae and Fructus Leonuri roguing are cleaned, add yellow wine and water, with Semen sojae atricolor with boiling, after well-done, taking out, being placed in frying pan, frying to dry tack free, take out, smash to pieces, dry;
(2) get Anoectochilus nefiliforme (Nakai) hara, Herba Viviae Sativae, Herba Ipomoeae Pes-Capraes and Herb Polygoni Chinensis rice-washed water clean and infiltrate 20-30 minute (preferred, infiltrate 23-27 minute; Be more preferably, infiltrate 25 minutes), pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) get Radix Crepidis elongatae clean, section, add Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat stir-fries to surface in time yellow, and taking-up, dries in the air cool;
(4) Fructus Schisandrae Chinensis, rhizoma woodwardiae, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, Fructus Elaeagni and Oryza sativa L. are cleaned, decoct with water together with step (1) (2) made crude drug, the 7-8 that amount of water is boiled crude drug quality is doubly (preferred, amount of water is 7.5 times of boiled crude drug quality), decoct twice, filter, collect medicinal liquid, merge twice filtrate;
(5) medicated powder is made in made for step (3) crude drug pulverizing, join in step (4) made filtrate, stir evenly, obtain decoction.
8. a kind of preparation method curing the Chinese medicine composition decoction of senile dementia as claimed in claim 7, it is characterized in that, step (4) decoct at every turn for big fire boil 10-20 minute after turn a little fire decoct 20 minutes (preferred, each decoct for big fire boil 15 minutes after a turn little fire decoct 20 minutes).
9. a kind of Chinese medicine composition of curing senile dementia as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) Fructus Ligustri Lucidi, Fructus Ilicis Cornutae and Fructus Leonuri roguing are cleaned, add yellow wine and water, with Semen sojae atricolor with boiling, after well-done, taking out, being placed in frying pan, frying to dry tack free, take out, smash to pieces, dry;
(2) get Anoectochilus nefiliforme (Nakai) hara, Herba Viviae Sativae, Herba Ipomoeae Pes-Capraes and Herb Polygoni Chinensis rice-washed water clean and infiltrate 20-30 minute (preferred, infiltrate 23-27 minute; Be more preferably, infiltrate 25 minutes), pull out, be placed in food steamer, Steam by water bath is saturating, takes out, dries;
(3) get Radix Crepidis elongatae clean, section, add Radix Crepidis elongatae sheet after Sal being put into frying pan heating, moderate heat stir-fries to surface in time yellow, and taking-up, dries in the air cool;
(4) Fructus Schisandrae Chinensis, rhizoma woodwardiae, Fructus osmanthi fragrantis (Osmanthus fragrans Lour.), Rhizoma Drynariae, Fructus Elaeagni and Oryza sativa L. are cleaned, decoct with water together with step (1) (2) made crude drug, decoct twice, each decoct for big fire boil 10-20 minute after turn a little fire and decoct 20 minutes (preferably, each decoction is turn little fire after big fire boils 15 minutes to decoct 20 minutes), filter, collect filtrate, merge twice filtrate, concentrated, dry, pulverize, obtained xeraphium;
(5) medicated powder is made in made for step (3) crude drug pulverizing, mix with step (4) made xeraphium, add auxiliary materials and mixing, be processed into tablet dosage form according to the preparation for processing of tablet, obtain tablet.
10. a kind of preparation method curing the Chinese medicine composition tablet of senile dementia as claimed in claim 9, is characterized in that, the 7-9 that step (4) amount of water is boiled crude drug quality is (preferred, amount of water is 8 times of boiled crude drug quality) doubly.
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| CN105535131A (en) * | 2015-12-29 | 2016-05-04 | 西南交通大学 | Application of cooked rhubarb micropowder in preparing drug for Alzheimer's disease |
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