CN102240380B - Traditional Chinese medicine preparation for treating senile vascular dementia - Google Patents
Traditional Chinese medicine preparation for treating senile vascular dementia Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating senile vascular dementia, prepared from the following components: 22-28 parts of prepared rehmannia root, 22-28 parts of prepared fleece-flower root, 22-28 parts of wolfberry fruit, 10-15 parts of glossy privet fruit, 10-15 parts of cornel, 12-18 parts of cistanche, 10-12 parts of morinda root, 12-18 parts of eucommia, 2-5 parts of prepared aconite root, 10-15 parts of angelica sinensis, 10-15 parts of safflower, 10-15 parts of tree peony bark, 12-18 parts of cyathula root, 12-18 parts of salvia, 5-8 parts of stiff silkworm, 10-15 parts of bitter caramon, 10-15 parts of acorus gramineus, 10-15 parts of polygala root, 10-15 parts of curcuma root, 10-15 parts of dried orange peel, 10-15 parts of tuckahoe, 12-18 parts of Chinese yam, 10-15 parts of pinellia tuber, 12-18 parts of magnolia vine fruit and 10-15 parts of licorice. The traditional Chinese medicine preparation disclosed by the invention is prepared from simon-pure traditional Chinese herbal medicines as raw materials by a traditional preparation method, has the efficacies of tonifying the kidney, replenishing essence, promoting blood circulation, removing obstruction in collaterals, resolving phlegm and inducing resuscitation, embodies the medication characteristic of concept of wholism in traditional Chinese medicine, and advocates strengthening the body resistance, eliminating the pathogenic factor, reinforcing and eliminating in combination, and addressing both the symptoms and root causes, thereby restoring deficiency of the kidney, eliminating phlegm and stagnation, removing obstruction in brain collaterals and restoring dementia.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation of treating old vascular dementia, belong to the field of Chinese medicines.
Background technology
(vascular dementia, VD) the no tangible cause of disease and inducement mainly contain various cerebrovascular disease such as cerebral arteriosclerosis, cerebral infarction, blood supply in brain deficiency to old vascular dementia, cause delayed ischemic neurological deficits and the acquired intelligence that produces is damaged syndrome.Belong to categories such as Chinese medicine " slow-witted disease ", " epilepsy ", " literary composition is silly ".Its concealment of falling ill, the course of disease is longer, often shows the undulatory property course of disease or is ladder appearance progress.Have more the focal location of existing cerebral infarction sign, cognitive dysfunction, visual space feel obstacle, central face tongue paralysis, hemiplegia, hemidysesthesia, muscular hypertonia, fibrae pyramidales is levied, pseudobulbar paralysis, memory, computing power go down, aphasia, alexia, symptoms such as logagraphia.Show that according to epidemiological study the sickness rate of over-65s old people vascular dementia is 1.2%～4.2%, and the trend that increases with the age is arranged.The traditional Chinese medical science thinks that primary disease pathology character is deficiency in origin and excess in superficiality, suffers from a deficiency of the kidney to be this, and expectorant, the stasis of blood are mark; Its sick position is at brain, and is in close relations with the heart, liver,spleen,kidney; With the asthenia of suffering from a deficiency of the kidney is its pathologic basis, and the turbid blood stasis of expectorant is its pathological characteristic with suffering from a deficiency of the kidney mutual for suffering from.The method of the old vascular dementia of treatment is a lot of at present, and western medical treatment takes to improve Therapeutic Method such as cerebral circulation, anti-platelet aggregation, brain metabolism resurrection more, often selects brain-caring compound for use; Huperzine A; Aspirin, medicines such as oxiracetam exist expense high; Drawbacks such as the course of disease is long, and the medicine toxic and side effects is big.Though treatments such as acupuncture rehabilitation have no side effect, medical expense is higher, and therapeutic effect is also as one wishes not to the utmost, brings very big inconvenience in economy and life for patient's family.Exactly because the limitation of above-mentioned therapy and toxic and side effects, can people just expect utilizing Chinese herbal medicine to treat old vascular dementia gradually.Best medicine is exactly to decide according to patient's the concrete state of an illness, and the present invention has just avoided the deficiency of above-mentioned therapy, is particular about determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, dialectically combines with differential diagnosis of diseases; Advocate strengthening vital QI to eliminate pathogenic factors, reinforcement and elimination in combination, giving consideration to both the incidental and fundamental, thus the expectorant repercussive is removed; Suffer from a deficiency of the kidney again, the brain network must be logical, the dull-witted recovery.
Summary of the invention
The present invention uses Chinese traditional Chinese herbal medicine to be raw material, and formulated through clinic tests and repeated verification, meets the theory of Chinese medicine.On this basis, cube send medicine, monarch, reasonable compatibility constitutes the prescription that yang blood and qi changes in the potion across-the-board regulation body, has demonstrated fully the administration features of differentiation of tcm.In kidney tonifying, essence replenishing, few more than the expectorant stasis of blood according to the prosperity and decline of state of an illness deficiency and excess, cooperate activating blood circulation to dissipate blood stasis and dredge the collateral, the agent that invigorating the spleen for dissipating phlegm is had one's ideas straightened out, strengthening vital QI to eliminate pathogenic factors, reinforcement and elimination in combination is suffered from a deficiency of the kidney multiple thereby make, and the expectorant stasis of blood must be removed, treating both the principal and secondary aspects of a disease, more the back is difficult for recurring.Prescription of the present invention is good effect not only, and taking convenience, and is without any side effects, is easy to accepted by the patient, can easily cure dementia.
A kind of Chinese medicine preparation of treating old vascular dementia, process by following component:
22～28 parts of Radix Rehmanniae Preparata, 22～28 parts of Radix Polygoni Multiflori Preparata, 22～28 parts of Fructus Lycii, 10～15 parts of Fructus Ligustri Lucidi, 10～15 parts of Fructus Corni; 12～18 parts of Herba Cistanches, 10～12 parts of Radix Morindae Officinaliss, 12～18 parts of the Cortexs Eucommiae, 2～5 parts of Radix Aconiti Lateralis Preparatas, 10～15 parts of Radix Angelicae Sinensis; 10～15 parts on Flos Carthami, 10～15 parts of Cortex Moutans, 12～18 parts of Radix Cyathulaes, 12～18 parts of Radix Salviae Miltiorrhizaes, 5～8 parts of Bombyx Batryticatus; 10～15 parts of Fructus Alpiniae Oxyphyllae, 10～15 parts of Rhizoma Acori Graminei, 10～15 parts of Radix Polygalaes, 10～15 parts of Radix Curcumaes, 10～15 parts of Pericarpium Citri Reticulataes; 10～15 parts in Poria, 12～18 parts of Rhizoma Dioscoreaes, 10～15 parts of the Rhizoma Pinelliaes, 12～18 parts of Fructus Schisandrae Chinensis, 10～15 parts in Radix Glycyrrhizae.
A kind of method for preparing of treating the Chinese medicine preparation of old vascular dementia:
Pressing formula proportion cleans Radix Rehmanniae Preparata, Radix Polygoni Multiflori Preparata, Fructus Lycii, Fructus Ligustri Lucidi, Fructus Corni, Herba Cistanches, Radix Morindae Officinalis, the Cortex Eucommiae, Radix Aconiti Lateralis Preparata, Radix Angelicae Sinensis, Flos Carthami, Cortex Moutan, Radix Cyathulae, Radix Salviae Miltiorrhizae, Bombyx Batryticatus, Fructus Alpiniae Oxyphyllae, Rhizoma Acori Graminei, Radix Polygalae, Radix Curcumae, Pericarpium Citri Reticulatae, Poria, Rhizoma Dioscoreae, the Rhizoma Pinelliae, Fructus Schisandrae Chinensis, 25 kinds of Chinese herbal medicine of Radix Glycyrrhizae; Putting into pressure cooker steamed 15～20 minutes in 150～180 ℃; Be cooled to room temperature; Be spread out on the bamboo mat to cover to place under the sunlight and dry with black cloth; After be ground into 300～400 order powder, incapsulate behind the mix homogeneously and get product.
A kind of Chinese medicine preparation of treating old vascular dementia can also be processed by following component: 23～27 parts of Radix Rehmanniae Preparata, 23～27 parts of Radix Polygoni Multiflori Preparata, 23～27 parts of Fructus Lycii, 11～14 parts of Fructus Ligustri Lucidi; 13～17 parts of Fructus Corni, 13～17 parts of Herba Cistanches, 11～14 parts of Radix Morindae Officinaliss, 13～17 parts of the Cortexs Eucommiae, 3～4 parts of Radix Aconiti Lateralis Preparatas; 11～14 parts of Radix Angelicae Sinensis, 11～14 parts on Flos Carthami, 11～14 parts of Cortex Moutans, 13～17 parts of Radix Cyathulaes; 13～17 parts of Radix Salviae Miltiorrhizaes, 6～7 parts of Bombyx Batryticatus, 11～14 parts of Fructus Alpiniae Oxyphyllae, 11～14 parts of Rhizoma Acori Graminei; 11～14 parts of Radix Polygalaes, 11～14 parts of Radix Curcumaes, 11～14 parts of Pericarpium Citri Reticulataes, 11～14 parts in Poria; 13～17 parts of Rhizoma Dioscoreaes, 11～14 parts of the Rhizoma Pinelliaes, 13～17 parts of Fructus Schisandrae Chinensis, 11～14 parts in Radix Glycyrrhizae.
The component of preferred following content: 24 parts of Radix Rehmanniae Preparata, 24 parts of Radix Polygoni Multiflori Preparata, 24 parts of Fructus Lycii, 12 parts of Fructus Ligustri Lucidi, 12 parts of Fructus Corni, 15 parts of Herba Cistanches, 12 parts of Radix Morindae Officinaliss; 15 parts of the Cortexs Eucommiae, 3 parts of Radix Aconiti Lateralis Preparatas, 12 parts of Radix Angelicae Sinensis, 12 parts on Flos Carthami, 12 parts of Cortex Moutans, 15 parts of Radix Cyathulaes; 15 parts of Radix Salviae Miltiorrhizaes, 6 parts of Bombyx Batryticatus, 12 parts of Fructus Alpiniae Oxyphyllae, 12 parts of Rhizoma Acori Graminei, 12 parts of Radix Polygalaes, 12 parts of Radix Curcumaes; 12 parts of Pericarpium Citri Reticulataes, 12 parts in Poria, 15 parts of Rhizoma Dioscoreaes, 12 parts of the Rhizoma Pinelliaes, 15 parts of Fructus Schisandrae Chinensis, 12 parts in Radix Glycyrrhizae.
The pharmacological property of each herbal medicine of the present invention is following:
Radix Rehmanniae Preparata: sweet in the mouth, slightly warm in nature is returned liver, kidney channel; Effect: nourishing the blood and yin, vital essence replenishing and marrow benifiting.Cure mainly the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, the cardiopalmus severe palpitation, dizzy, tinnitus, early whitening of beard and hair etc.
Radix Polygoni Multiflori: bitter in the mouth, sweet, puckery, slightly warm in nature is returned liver, kidney channel; Effect: invigorating the liver and kidney, benefiting essence-blood, black beard and hair, bone and muscle strengthening.Cure mainly essence and blood and lose void, dizziness and blurred vision, early whitening of beard and hair, diseases such as soreness of the waist and knees.Can strong muscle benefit smart, physical strength profiting be prolonged life, and slow down aging is arranged, antioxidation and to the protective effect of nerve.
Fructus Lycii: sweet in the mouth, property are put down, and return liver, kidney, lung meridian; Effect: nourishing the liver and kidney, replenishing vital essence to improve eyesight.Main component is LBP, betanin, and raise immunity is arranged, and slow down aging protects the liver, blood sugar lowering, blood fat reducing, fatigue-resisting function.
Fructus Ligustri Lucidi: sweet in the mouth, hardship, cool in nature, return liver, kidney channel; Effect: liver and kidney tonifying, clearing away heat to improve acuity of vision.
Fructus Corni: sour in the mouth, slightly warm in nature is returned liver, kidney channel; Effect: liver and kidney tonifying, restrain astringent or styptic treatment for spontaneous sweating.Cure mainly caused by liver and kidney deficiency, have a dizzy spell, soreness of the waist and knees, impotence and seminal emission, incontinence of urine, diseases such as incessant sweating due to debility.
Herba Cistanches: sweet in the mouth, salty, warm in nature, return kidney, large intestine channel; Effect: reinforcing the kidney and supporting YANG, loosening bowel to relieve constipation.Cure mainly sexual impotence, chills and pain of the waist and kness, muscles and bones is unable, the constipation that dryness of the intestine Tianjin is withered etc.
Radix Morindae Officinalis: acrid in the mouth, sweet, slightly warm in nature is returned kidney channel; Effect: reinforcing the kidney and supporting YANG, expelling wind and removing dampness.
The Cortex Eucommiae: sweet in the mouth, warm in nature, return liver, kidney channel; Effect: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.
Radix Aconiti Lateralis Preparata: acrid in the mouth, hot in nature, GUIXIN, kidney, spleen channel; Effect: recuperating depleted YANG and rescuing the patient from collapse, it is supporing yang to mend fire, dispersing cold for relieving pain.Main Ingredients and Appearance is an alkaloid, and blood vessel dilating is arranged, and increasing blood flow improves the blood circulation effect.
Radix Angelicae Sinensis: sweet in the mouth, suffering, warm in nature, return liver, the heart, spleen channel; Effect: enrich blood, invigorate blood circulation, hemostasis, intestine moistening.Cure mainly blood deficiency, blood stasis, diseases such as hyperlipidemia, and antiinflammatory is arranged, effects such as antioxidation and removing free radical.
Flos Carthami: acrid in the mouth, warm in nature, GUIXIN, Liver Channel; Effect: blood circulation promoting and blood stasis dispelling, stimulate the menstrual flow.Main component is a safflower yellow, and anticoagulation is arranged, and antithrombotic forms, blood vessel dilating, microcirculation improvement, and resisting myocardial ischemia, anti-cerebral ischemia, effects such as blood fat reducing.
Cortex Moutan: bitter in the mouth, suffering, cold nature, GUIXIN, liver, kidney channel; Effect: promoting blood circulation to remove blood stasis.Main component is a paeonol, and the central nervous system is had tranquilizing soporific, anticonvulsant action, and cardiovascular and cerebrovascular vessel are played anti-platelet aggregation, changes hemorheology, anti-cardiac-cerebral ischemia, effects such as atherosclerosis.
Radix Cyathulae: bitter in the mouth, acid, property is flat, returns liver, kidney channel; Effect: blood circulation promoting and blood stasis dispelling, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, conducting blood to flow downwards.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature, GUIXIN, pericardium, Liver Channel; Effect: blood circulation promoting and blood stasis dispelling, the removing heat from blood eliminating carbuncle, relieving restlessness clears away heart-fire.Main component is a TANSHINONES, and danshensu has anti-cardiac-cerebral ischemia, antithrombotic, and microcirculation improvement promotes the reparation and the regeneration of tissue, sedation and analgesia, antioxidation, the effect of removing free radical.
Bombyx Batryticatus: salty in the mouth, suffering, property is flat, returns liver, lung meridian; Effect: relieving spasm by subduing liver-wind, detoxicating and resolving stagnation of pathogens, removing obstruction in the collateral to relieve pain.
Fructus Alpiniae Oxyphyllae: acrid in the mouth, warm in nature, return spleen, kidney channel; Effect: saliva, warming the kidney controlling nocturnal emission with astringent drugs reducing urination are taken the photograph in the kidney warming appetizing.Be used to treat spleen-kidney vacuity cold, the seminal emission enuresis, nocturia such as increases at disease.
Rhizoma Acori Graminei: acrid in the mouth, warm in nature, GUIXIN, stomach warp; Effect: resuscitation inducing and mind tranquilizing, removing dampness to restore normal function of the stomach.Being used to treat turbid damp, to hoodwink clearly due to the key mind chaotic, forgetful, diseases such as tinnitus.Can antidepressant with improve the learning and memory effect.
Radix Polygalae: acrid in the mouth, hardship, slightly warm in nature is returned lung, heart channel; Effect: mind tranquilizing and the heart calming, the eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Cure mainly the mental disorder due to the phlegmatic mental confusion, staring spells, palpitation with fear is uneasy, diseases such as insomnia forgetfulness.Main component is a polygalin, can dementia and the effect of protecting brain.
Radix Curcumae: acrid in the mouth, hardship, cold in nature, GUIXIN, liver, gallbladder meridian; Effect: promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, removing heat from blood clears away heart-fire, promoting the function of the gallbladder to alleviate jaundice.Be used to treat turbid pathogen and hoodwink key clearly, feeling of oppression and fullness in the chest and epigastrium, obnubilation, and mental disorder stops up resistance, the epilepsy due to the inaccessible thinking or disease such as demented.
Pericarpium Citri Reticulatae: lightly seasoned, sweet, warm in nature, return spleen, lung meridian; Effect: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Main Ingredients and Appearance is a Flavonoid substances, and heart is had excitation, and blood vessel is had dilating effect, and stronger antioxidation is arranged.
Poria: sweet in the mouth, light, property is flat, GUIXIN, spleen, kidney channel; Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Calmness is arranged, antitumor, the anti-ageing pharmacological action of waiting for a long time.
Rhizoma Dioscoreae: sweet in the mouth, property is flat, returns spleen, lung, kidney channel; Effect: supplementing QI and nourishing YIN, spleen reinforcing lung kidney.Cure mainly insufficiency of the spleen leading to overabundance of dampness, the deficiency of the lung is breathed with cough, diseases such as emission due to deficiency of the kidney, frequent micturition.
The Rhizoma Pinelliae: acrid in the mouth, warm in nature, poisonous, return spleen, stomach, lung meridian; Effect: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.
Fructus Schisandrae Chinensis: sour in the mouth, warm in nature, return lung, stomach, heart channel; Effect: the nourishing kidney of astringing the lung, the arresting sweating that promotes the production of body fluid, arresting seminal emission antidiarrheal, mind tranquilizing and the heart calming.
Radix Glycyrrhizae: sweet in the mouth, property is flat, GUIXIN, lung, spleen, stomach warp; Effect: invigorating the spleen and replenishing QI, nourishing the lung to arrest cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.The ability arrhythmia, blood fat reducing, atherosclerosis suppresses platelet aggregation, antitumor, effects such as anti-tissue fibering.
Diagnostic criteria:
The Western medicine diagnose standard meets relevant dementia diagnosis standard in APA,American Psychiatric Association's " diagnostic & statistical manual of mental disorder " IV version (DSM-IV), all adopts Hai Jinsiji ischemia index quantization table (HZS), and integration is more than 7 minutes.Diagnosis, the differentiation of symptoms and signs for classification of syndrome standard of the senile dementia that tcm diagnosis standard reference nineteen ninety whole nation traditional Chinese medical science senile dementia special topic scientific seminar formulates, all genus deficiency of marrow-reservoir, caused by liver and kidney deficiency, asthenia of both the spleen and kidney, turbid phlegm blocking the clear orifices, syndrome of qi stagnation and blood stasis all can be included in.
Exclusion standard:
Age is at the right side of fifty, more than 70 years old; The patient that non-vascular is dull-witted; Vascular dementia belongs to the conscience fire and contains the card person; Companion's severe cardiac, lung, liver, kidney, E&M obstacle patient; Be unworthy of and therapist.
Efficacy assessment standard:
According to changing before and after each scale treatment, formulate criterion of therapeutical effect in conjunction with clinical symptoms.Produce effects: cardinal symptom and sign are obviously improved, and can correctly answer a question, and conscious mind is quick on the draw, and daily life can take care of oneself, and can carry out general social activity; Take a turn for the better: main mental symptom alleviates to some extent or part disappears, and life can take care of oneself basically, can answer basic problem, but bradykinesia, intelligence still has obstacle; Invalid: cardinal symptom does not have improvement or conditions of patients has development, can not correctly answer a question, and can't take care of oneself, and mind is dull-witted.
Formula and prescription of the present invention is reasonable, selects YAOJING good, establishes for the etiology and pathogenesis to old vascular dementia in fact; In kidney tonifying, essence replenishing,, add less more than the expectorant stasis of blood and simplify sanction, cooperate activating blood circulation to dissipate blood stasis and dredge the collateral according to the prosperity and decline of state of an illness deficiency and excess; The agent that invigorating the spleen for dissipating phlegm is had one's ideas straightened out, strengthening vital QI to eliminate pathogenic factors, giving consideration to both the incidental and fundamental.
The specific embodiment
Below in conjunction with embodiment and case the present invention is further described:
Embodiment 1:
A kind of Chinese medicine preparation of treating old vascular dementia, process by following component:
Radix Rehmanniae Preparata 280 grams, Radix Polygoni Multiflori Preparata 280 grams, Fructus Lycii 280 grams, Fructus Ligustri Lucidi 150 grams, Fructus Corni 150 grams, Herba Cistanches 180 grams, Radix Morindae Officinalis 120 grams; The Cortex Eucommiae 180 grams, Radix Aconiti Lateralis Preparata 50 grams, Radix Angelicae Sinensis 150 grams, Flos Carthami 150 grams, Cortex Moutan 150 grams, Radix Cyathulae 180 grams; Radix Salviae Miltiorrhizae 180 grams, Bombyx Batryticatus 80 grams, Fructus Alpiniae Oxyphyllae 150 grams, Rhizoma Acori Graminei 150 grams, Radix Polygalae 150 grams, Radix Curcumae 150 grams; Pericarpium Citri Reticulatae 150 grams, Poria 150 grams, Rhizoma Dioscoreae 180 grams, the Rhizoma Pinelliae 150 grams, Fructus Schisandrae Chinensis 180 grams, Radix Glycyrrhizae 150 grams.
A kind of method for preparing of treating the Chinese medicine preparation of old vascular dementia:
Pressing formula proportion cleans Radix Rehmanniae Preparata, Radix Polygoni Multiflori Preparata, Fructus Lycii, Fructus Ligustri Lucidi, Fructus Corni, Herba Cistanches, Radix Morindae Officinalis, the Cortex Eucommiae, Radix Aconiti Lateralis Preparata, Radix Angelicae Sinensis, Flos Carthami, Cortex Moutan, Radix Cyathulae, Radix Salviae Miltiorrhizae, Bombyx Batryticatus, Fructus Alpiniae Oxyphyllae, Rhizoma Acori Graminei, Radix Polygalae, Radix Curcumae, Pericarpium Citri Reticulatae, Poria, Rhizoma Dioscoreae, the Rhizoma Pinelliae, Fructus Schisandrae Chinensis, 25 kinds of Chinese herbal medicine of Radix Glycyrrhizae; Putting into pressure cooker steamed 15～20 minutes in 150～180 ℃; Be cooled to room temperature; Be spread out on the bamboo mat to cover to place under the sunlight and dry with black cloth; After be ground into 300～400 order powder, incapsulate behind the mix homogeneously and get product.
Usage and consumption:
Warm boiled water, each 4, every day 3 times, every pastille 1.5 grams, 30 is 1 course of treatment.
Embodiment 2:
A kind of Chinese medicine preparation of treating old vascular dementia, process by following component:
Radix Rehmanniae Preparata 220 grams, Radix Polygoni Multiflori Preparata 220 grams, Fructus Lycii 220 grams, Fructus Ligustri Lucidi 100 grams, Fructus Corni 100 grams, Herba Cistanches 120 grams, Radix Morindae Officinalis 100 grams; The Cortex Eucommiae 120 grams, Radix Aconiti Lateralis Preparata 20 grams, Radix Angelicae Sinensis 100 grams, Flos Carthami 100 grams, Cortex Moutan 100 grams, Radix Cyathulae 120 grams; Radix Salviae Miltiorrhizae 120 grams, Bombyx Batryticatus 50 grams, Fructus Alpiniae Oxyphyllae 100 grams, Rhizoma Acori Graminei 100 grams, Radix Polygalae 100 grams, Radix Curcumae 100 grams; Pericarpium Citri Reticulatae 100 grams, Poria 100 grams, Rhizoma Dioscoreae 120 grams, the Rhizoma Pinelliae 100 grams, Fructus Schisandrae Chinensis 120 grams, Radix Glycyrrhizae 100 grams.
A kind of method for preparing, usage and consumption of treating the Chinese medicine preparation of old vascular dementia is identical with embodiment 1.
Embodiment 3:
The optimum weight proportioning that the present invention treats raw material of Chinese medicine in the Chinese medicine preparation of old vascular dementia is:
Radix Rehmanniae Preparata 240 grams, Radix Polygoni Multiflori Preparata 240 grams, Fructus Lycii 240 grams, Fructus Ligustri Lucidi 120 grams, Fructus Corni 120 grams, Herba Cistanches 150 grams, Radix Morindae Officinalis 120 grams; The Cortex Eucommiae 150 grams, Radix Aconiti Lateralis Preparata 30 grams, Radix Angelicae Sinensis 120 grams, Flos Carthami 120 grams, Cortex Moutan 120 grams, Radix Cyathulae 150 grams; Radix Salviae Miltiorrhizae 150 grams, Bombyx Batryticatus 60 grams, Fructus Alpiniae Oxyphyllae 120 grams, Rhizoma Acori Graminei 120 grams, Radix Polygalae 120 grams, Radix Curcumae 120 grams; Pericarpium Citri Reticulatae 120 grams, Poria 120 grams, Rhizoma Dioscoreae 150 grams, the Rhizoma Pinelliae 120 grams, Fructus Schisandrae Chinensis 150 grams, Radix Glycyrrhizae 120 grams.
A kind of method for preparing, usage and consumption of treating the Chinese medicine preparation of old vascular dementia is identical with embodiment 1.
Embodiment 4:
A kind of Chinese medicine preparation of treating old vascular dementia, process by following component:
Radix Rehmanniae Preparata 200 grams, Radix Polygoni Multiflori Preparata 200 grams, Fructus Lycii 200 grams, Fructus Ligustri Lucidi 80 grams, Fructus Corni 80 grams, Herba Cistanches 100 grams, Radix Morindae Officinalis 80 grams; The Cortex Eucommiae 100 grams, Radix Aconiti Lateralis Preparata 20 grams, Radix Angelicae Sinensis 80 grams, Flos Carthami 80 grams, Cortex Moutan 80 grams, Radix Cyathulae 100 grams; Radix Salviae Miltiorrhizae 100 grams, Bombyx Batryticatus 50 grams, Fructus Alpiniae Oxyphyllae 80 grams, Rhizoma Acori Graminei 80 grams, Radix Polygalae 80 grams, Radix Curcumae 80 grams; Pericarpium Citri Reticulatae 80 grams, Poria 80 grams, Rhizoma Dioscoreae 100 grams, the Rhizoma Pinelliae 80 grams, Fructus Schisandrae Chinensis 100 grams, Radix Glycyrrhizae 80 grams.
A kind of method for preparing, usage and consumption of treating the Chinese medicine preparation of old vascular dementia is identical with embodiment 1.
Test data:
1. clinical data
Select clinic case 240 examples to be treatment group, male 142 examples, women 98 examples, 50～70 years old age, the course of disease 6 months～8 years at random; Select the same period 100 examples as matched group, male 61 examples, women 39 examples, 50～69 years old age, the course of disease 6 months～7.5 years.Two groups at aspects such as sex, age, the course of disease, the state of an illness through statistical procedures, there was no significant difference (P＞0.05) has comparability.
2. Therapeutic Method
240 examples are organized in treatment, oral medicine of the present invention, each 4, every day 3 times, warm boiled water; Matched group 100 examples are taken the oxiracetam capsule that certain pharmaceutical factory produces, each 800mg (2), every day 3 times, warm boiled water.Two groups equal 30 days be 1 course of treatment, obey 2 courses of treatment altogether.
3. therapeutic outcome
240 examples are organized in treatment, produce effects 114 examples (47.5%), 87 examples that take a turn for the better (36.25%), invalid 39 examples (16.25%), total effective rate 83.75%; Matched group 100 examples, produce effects 22 examples (22%), 32 examples that take a turn for the better (32%), invalid 46 examples (46%), total effective rate 54%.Two groups of curative effects compare, through X
2Check, the treatment group obviously is superior to matched group, has significant difference (P＜0.05).
4. model case:
Case 1: Zhang, the man, 56 years old, the retired cadre, first visit on May 4 in 1998, the patient once in 6 months prolapse carbuncle in the occipital region infractions, had a dull expression on one's face at present, bradyphrenia, hypomnesis judges that cognition time, place, personage's ability go down, through failing to respond to any medical treatment in many ways.The visible gyrus of cranium brain CT examination flattens, the broadening of brain ditch, and it is big that ventricles of the brain pond becomes, and the pathological change of cerebral cortex atrophy is diagnosed as old vascular dementia.After 3 courses of treatment, all cards are basic to disappear through clothes Drug therapy of the present invention, and life can take care of oneself, and follows up a case by regular visits to not recurrence in 1 year.
Case 2: Lee, the man, 65 years old, the retired cadre was in first visit on August 5 in 2006; Have hypertension, hyperlipidemia medical history, trembling of limbs occurs over nearly 1 year, walk with difficulty, both hands can not be held thing; Hypomnesis, the understandability obstacle, language repeats, frequent micturition; Aversion to cold and cold limbs, the visible gyrus of cranium brain MRI inspection flattens, and the pathological change of brain atrophys such as brain ditch broadening is diagnosed as old vascular dementia.Through clothes 3 courses of treatment of Drug therapy of the present invention, symptom disappears basically, can steadily walk at a slow speed, and both hands can accomplish diet, hold basic activity such as thing, and it is normal that the human thinking ability is recovered, and follows up a case by regular visits to not recurrence in 1 year.
Case 3: Zhang, woman, 68 years old, retired worker; In first visit on October 15 in 2007, have medical histories such as hypertension, hyperlipidemia, atherosclerosis, once suffered from cerebral infarction 2 times, carrying out property of memory goes down over 6 years; The understandability obstacle, the time auditory hallucination, hallucination, susceptible to fright irritability, insomnia and dreamful sleep arranged; Vertigo and tinnitus, indigestion and loss of appetite abdominal distention, thready and weak pulse without strength is diagnosed as old vascular dementia.Through clothes 2 courses of treatment of Drug therapy of the present invention, symptom complete obiteration, advise its 1 course of treatment of clothes of continuing as a means of consolidation, follow up a case by regular visits to not recurrence in 1 year.
Case 4: Ma, the man, 62 years old, the peasant was in calendar year 2001 first visit on JIUYUE 25; The prolapse carbuncle in the occipital region was hemorrhage in 1 year, the left limb moving obstacle occurred after the underwent operative treatment, and cognitive competence goes down, and speech is unfavorable, the buccal flushing; Lip and nail are purple dark, and scaly dry skin can't take care of oneself, and is diagnosed as old vascular dementia.Through clothes 3 courses of treatment of Drug therapy of the present invention, most of transference cure, life can take care of oneself basically, follows up a case by regular visits to not recurrence in 1 year.
Case 5: take charge of certain, the woman, 69 years old, the retired worker, in December in 2010 first visit on the 8th, it is surplus to suffer from vascular dementia 5 years, and tangible hypophrenia, personality change are arranged, and the moral ethics disappearance can't take care of oneself, and is carrying out property and increases the weight of.Through clothes 3 courses of treatment of Drug therapy of the present invention, all cards alleviate, and life can take care of oneself, and follows up a case by regular visits to not recurrence in 1 year.
Claims (3)
1. a Chinese medicine preparation of treating old vascular dementia is characterized in that, is processed by following component: 22～28 parts of Radix Rehmanniae Preparata, 22～28 parts of Radix Polygoni Multiflori Preparata, 22～28 parts of Fructus Lycii; 10～15 parts of Fructus Ligustri Lucidi, 10～15 parts of Fructus Corni, 12～18 parts of Herba Cistanches, 10～12 parts of Radix Morindae Officinaliss, 12～18 parts of the Cortexs Eucommiae; 2～5 parts of Radix Aconiti Lateralis Preparatas, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts on Flos Carthami, 10～15 parts of Cortex Moutans, 12～18 parts of Radix Cyathulaes; 12～18 parts of Radix Salviae Miltiorrhizaes, 5～8 parts of Bombyx Batryticatus, 10～15 parts of Fructus Alpiniae Oxyphyllae, 10～15 parts of Rhizoma Acori Graminei; 10～15 parts of Radix Polygalaes, 10～15 parts of Radix Curcumaes, 10～15 parts of Pericarpium Citri Reticulataes, 10～15 parts in Poria; 12～18 parts of Rhizoma Dioscoreaes, 10～15 parts of the Rhizoma Pinelliaes, 12～18 parts of Fructus Schisandrae Chinensis, 10～15 parts in Radix Glycyrrhizae.
2. a kind of Chinese medicine preparation of treating old vascular dementia according to claim 1 is characterized in that, is processed by following component: 24 parts of Radix Rehmanniae Preparata, 24 parts of Radix Polygoni Multiflori Preparata, 24 parts of Fructus Lycii, 12 parts of Fructus Ligustri Lucidi; 12 parts of Fructus Corni, 15 parts of Herba Cistanches, 12 parts of Radix Morindae Officinaliss, 15 parts of the Cortexs Eucommiae, 3 parts of Radix Aconiti Lateralis Preparatas, 12 parts of Radix Angelicae Sinensis; 12 parts on Flos Carthami, 12 parts of Cortex Moutans, 15 parts of Radix Cyathulaes, 15 parts of Radix Salviae Miltiorrhizaes, 6 parts of Bombyx Batryticatus; 12 parts of Fructus Alpiniae Oxyphyllae, 12 parts of Rhizoma Acori Graminei, 12 parts of Radix Polygalaes, 12 parts of Radix Curcumaes, 12 parts of Pericarpium Citri Reticulataes; 12 parts in Poria, 15 parts of Rhizoma Dioscoreaes, 12 parts of the Rhizoma Pinelliaes, 15 parts of Fructus Schisandrae Chinensis, 12 parts in Radix Glycyrrhizae.
3. the described a kind of method for preparing of treating the Chinese medicine preparation of old vascular dementia of claim 1; It is characterized in that: press formula proportion Radix Rehmanniae Preparata, Radix Polygoni Multiflori Preparata, Fructus Lycii, Fructus Ligustri Lucidi, Fructus Corni, Herba Cistanches, Radix Morindae Officinalis, the Cortex Eucommiae, Radix Aconiti Lateralis Preparata, Radix Angelicae Sinensis, Flos Carthami, Cortex Moutan, Radix Cyathulae, Radix Salviae Miltiorrhizae, Bombyx Batryticatus, Fructus Alpiniae Oxyphyllae, Rhizoma Acori Graminei, Radix Polygalae, Radix Curcumae, Pericarpium Citri Reticulatae, Poria, Rhizoma Dioscoreae, the Rhizoma Pinelliae, Fructus Schisandrae Chinensis, 25 kinds of Chinese herbal medicine of Radix Glycyrrhizae are cleaned; Putting into pressure cooker steamed 15～20 minutes in 150～180 ℃; Be cooled to room temperature; Be spread out on the bamboo mat to cover to place under the sunlight and dry with black cloth; After be ground into 300～400 order powder, incapsulate behind the mix homogeneously and get product.
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| CN103505674B (en) * | 2013-07-30 | 2015-05-27 | 吕士芹 | Traditional Chinese medicine for treating male senile dementia |
| CN103393831A (en) * | 2013-08-22 | 2013-11-20 | 上海市中医老年医学研究所 | Chinese medicine composition for treating vascular dementia and preparation and application thereof |
| CN103599454A (en) * | 2013-11-28 | 2014-02-26 | 唐翔 | Traditional Chinese medicine for treating arteriosclerosis |
| CN104189428A (en) * | 2014-09-09 | 2014-12-10 | 王艳丽 | Traditional Chinese medicinal preparation for treating proliferation of mammary glands |
| CN105148073A (en) * | 2015-09-30 | 2015-12-16 | 郑梅 | Chinese herb composition for treating senile dementia and preparation method |
| CN108743810A (en) * | 2018-07-13 | 2018-11-06 | 芜湖耄智生物科技有限公司 | Chinese medicine composition and preparation method thereof for preventing senile dementia |
| CN110934998A (en) * | 2019-12-19 | 2020-03-31 | 广西中医药大学第一附属医院 | Composition for treating severe dementia, preparation and application thereof |
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| CN101590163B (en) * | 2008-05-27 | 2012-05-23 | 丁大愚 | Medicament for treating dementia and preparation method thereof |
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