CN103386017B - Medlar-nourishing amino acid oral solution for nourishing kidney and replenishing essence and preparation process thereof - Google Patents
Medlar-nourishing amino acid oral solution for nourishing kidney and replenishing essence and preparation process thereof Download PDFInfo
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Abstract
The invention discloses a medlar-nourishing amino acid oral solution for nourishing kidney and replenishing essence and a preparation method thereof. The oral solution is characterized by being prepared from the following raw materials in parts by weight: 250-350 parts of composite amino acid powder, 180-220 parts of medlar, 85-95 parts of poria, 110-130 parts of white peony root, 120-160 parts of bighead atractylodes rhizome, 110-130 parts of dwarf lilyturf tuber, 55-65 parts of liquorice, 110-130 parts of raw rehmannia root, 70-90 parts of scrophularia ningpoensis, 180-220 parts of eucommia ulmoides, 70-90 parts of honeysuckle flower, 160-200 parts of rhizoma anemarrhenae, 100-140 parts of rhizoma acori graminei, and 140-160 parts of Chinese yam. The oral solution is strict in preparation, and can be used for regulating qi circulation and strengthening spleen, tranquilizing mind by nourishing the heart, and nourishing blood and liver to achieve the effects of taking essence, blood and qi at the same time and nourishing liver, kidney, heart and spleen on the basis of nourishing kidney and replenishing essence in a main role and warming and invigorating kidney yang in an assisting role, and balancing yin and yang. The oral solution has the functions of nourishing kidney and replenishing essence, nourishing both liver and kidney, tonifying qi and strengthening spleen, tranquilizing by nourishing heart, and clearing heat and removing toxicity.
Description
Technical field
The present invention relates to a kind of Qi profit amino acids oral-liquor and preparation technology thereof of Zishen fill fine, belong to technical field of Chinese medicines.
Background technology
Kidney yin, kidney yang are also known as Kidney-Yin, kidney-Yang, Kidney-Yin, Yuanyang.Kidney yin, kidney yang always lead the negative and positive of whole body.The main Physiological Function of kidney yin be promote body moist, quiet, be shaped and restriction sun heat, by internal organs, meridians, body, official's keys of three burnt arrival whole bodies.The moon of Gu Shenyinwang then whole body is all prosperous; Kidney yin declines, then the moon of whole body then all declines; Kidney yin is died, then the moon of whole body is then all died.Deficiency of the kidney yin, is the disease of kidney YIN-fluid being insufficient performance, how is impairment of the kidney by prolonged illness, or innate deficiency sexual strain, or mistake takes caused by the product of warm-dryness syndrome misfortune the moon.Deficiency of the kidney yin shows as soreness of the waist and knees, has a dizzy spell, tinnitus, and seminal emission, quenches one's thirst, and osteopyrexia and fever is easily tired, feverish sensation in the palms and soles, irritability, dryness of the mouth and throat, and tooth shakes, and non-closure of fontanels jin infants, the few tongue of red tongue, thready and rapid pulse etc.Modern medicine occurs from the damage type of a certain organ, and Diagnosis and Treat exists certain difficulty, and Western medicine principle of medication is suited the remedy to the case, cure the symptoms, not the disease, cannot from the basic misery solving patient, and long-term taking can bring other adverse side effects, increases Liver and kidney burden.Modern technologies have disclosed the prescription of a variety of the kidney invigorating, medicine, health food, few concern deficiency of the kidney yin, cause prescription imbalance of YIN and YANG, such as CN96115423 discloses a kind of kidney-reinforcing Yang strengthening powder, and number of patent application CN02144696.2 Chinese patent literature discloses a kind of capsule for nourishing kidney and strengthening Yang.Traditional Chinese medical science conventional formulation " LIUWEI DIHUANG WAN " YIN nourishing good effect, process modification or plus-minus prescription is carried out in the market on this side basis, such as CN03124644.3 " preparation technology that Lycium-rehmannia is new and preparation thereof " etc., technique relative complex and lack autonomous innovation and restricted application, can not meet medication demand and the selectivity of the patient of different demand.
Summary of the invention
The object of the invention is to overcome above-mentioned technical deficiency, provide a kind of scientific formulation reasonable, composition is accurate, evident in efficacy through clinical observation treatment, the amino acids oral-liquor of the Zishen fill fine had no adverse reaction and preparation technology thereof.
One of technical solution of the present invention: a kind of Qi profit amino acids oral-liquor of Zishen fill fine, be made up of the raw material of following weight parts:
Aminoacids complex powder 250-350 parts, Fructus Lycii 180-220 parts, 85-95 parts, Poria, the Radix Paeoniae Alba 110-130 parts, the Rhizoma Atractylodis Macrocephalae 120-160 parts, Radix Ophiopogonis 110-130 parts, 55-65 parts, Radix Glycyrrhizae, 110-130 parts, the Radix Rehmanniae, Radix Scrophulariae 70-90 parts, the Cortex Eucommiae 180-220 parts, Flos Lonicerae 70-90 parts, the Rhizoma Anemarrhenae 160-200 parts, Rhizoma Acori Graminei 100-140 parts, Rhizomadioscoreae 140-160 parts.
Preferably be made up of the raw material of following weight parts:
Aminoacids complex powder 300 parts, Fructus Lycii 200 parts, 90 parts, Poria, the Radix Paeoniae Alba 120 parts, the Rhizoma Atractylodis Macrocephalae 150 parts, Radix Ophiopogonis 120 parts, 60 parts, Radix Glycyrrhizae, 120 parts, the Radix Rehmanniae, Radix Scrophulariae 80 parts, the Cortex Eucommiae 200 parts, Flos Lonicerae 80 parts, the Rhizoma Anemarrhenae 180 parts, Rhizoma Acori Graminei 120 parts, Rhizomadioscoreae 150 parts.
Technical solution of the present invention two: a kind of preparation method of Qi profit amino acids oral-liquor of Zishen fill fine, Fructus Lycii is got by the weight proportion of prescription, Poria, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Radix Glycyrrhizae, the Radix Rehmanniae, Radix Scrophulariae, Flos Lonicerae, the Cortex Eucommiae, the Rhizoma Anemarrhenae, Rhizoma Acori Graminei and Rhizomadioscoreae, add 6-8 times amount water soaking 30min-60min, first time decocts 60-120min, under preferably wherein after Flos Lonicerae and Rhizoma Acori Graminei two taste medical material, filter, filtering residue adds 4-6 times of water gagings and continues decoction 60-90min, filter, merging filtrate, concentrated, add Aminoacids complex powder, flavoring agent 0.2% aspartame and antiseptic 0.5% sodium benzoate, stir evenly, sterilizing, encapsulation, obtain oral liquid.
Technical solution of the present invention three: Qi profit amino acids oral-liquor soreness of the waist and knees caused by the treatment hepatic and renal YIN deficiency of described a kind of Zishen fill fine, have a dizzy spell, quench one's thirst, osteopyrexia and fever, feverish sensation in the palms and soles, irritability, dryness of the mouth and throat, tooth shakes, and non-closure of fontanels jin infants, the few tongue of red tongue, the application in thready and rapid pulse.
Deficiency of the kidney yin, is the disease of kidney YIN-fluid being insufficient performance, how is impairment of the kidney by prolonged illness, or innate deficiency sexual strain, or mistake takes caused by the product of warm-dryness syndrome misfortune the moon.Pharmaceutical formulation of the present invention is through clinical practice for many years, in conjunction with Basic Theories of Chinese Medicine and modern scientific research method, investigates further and develops, meticulously screen raw material of Chinese medicine:
Fructus Lycii: sweet in the mouth, property are flat, return
liver Channel,
kidney channel,
lung meridian, nourishing the liver and kidney, replenishing vital essence to improve eyesight.
Poria: sweet in the mouth, flat, enters the heart, lung, spleen channel, has eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming.
The Radix Paeoniae Alba: enter liver, spleen channel, nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives antiperspirant.
The Rhizoma Atractylodis Macrocephalae: bitter, sweet, temperature, returns spleen, stomach warp.Air making-up and spleen enlivening, dampness diuretic.
Radix Ophiopogonis: sweet, micro-hardship, to be slightly cold, GUIXIN, lung, stomach warp, YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.
Radix Glycyrrhizae: property is put down, sweet in the mouth, invigorating the spleen and replenishing QI, relieving cough and moistening lung, emergency is detoxified, and is in harmonious proportion hundred medicines.
The Radix Rehmanniae: sweet, cold, GUIXIN, liver, kidney channel, clearing away heat and cooling blood, yin nourishing, promotes the production of body fluid.
Radix Scrophulariae: sweet in the mouth, hardship, salty, is slightly cold, returns lung, stomach, kidney channel, clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing.
The Cortex Eucommiae: sweet, puckery, temperature, enters liver, kidney channel, invigorating the liver and kidney, bone and muscle strengthening, antiabortive.
Flos Lonicerae: micro-hardship, pungent, sweet; Cold, return lung, the heart, stomach large intestine channel, heat-clearing and toxic substances removing, pus is removed in removing toxic substances.
The Rhizoma Anemarrhenae: bitter, sweet, cold, return lung, stomach, kidney channel, clearing away heat-fire,
yIN nourishingmoisturize.
Rhizoma Acori Graminei: pungent, bitter, temperature, GUIXIN, stomach warp, removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.
Rhizoma Dioscoreae: sweet, property is put down.Return spleen, lung, kidney channel, spleen reinforcing lung kidney qi, strengthening spleen and lung kidney yin.
Kidney is " the congenital foundation " " life originally ", and its physiological function is store essential substances, main water, main improving inspiration by invigorating kidney-QI, the raw marrow of main bone mainly.Kidney institute store essential substances gas is the origin that life is formed, the material base of advantage growth in humans growth and reproduction, is organ yin-yang basis.Clinical Chang Yin suffers from a deficiency of the kidney and affects deficiecny of liver-YIN, and deficiency of the kidney yin, deficiency of kidney-QI cause caused by deficiency of liver-YIN.The present invention reuses Fructus Lycii and the Cortex Eucommiae, Fructus Lycii sweet in the mouth, property put down, return liver, kidney channel, this product profit and nourish, specially in the kidney invigorating, lung moistening, promote the production of body fluid, QI invigorating, be the key medicine of Liver and kidney kidney-YIN being deficient, tired interior-heat tonification; Cortex Eucommiae color is purple and moisten, and sweet in the mouth is micro-pungent, and its temperature is flat, and Gan Wenneng mends, micro-pungent energy profit, therefore can enter liver and the kidney invigorating, and son can make mother real also; The Rhizoma Anemarrhenae is bitter, sweet, and cold, return lung, stomach, kidney channel, it is with having four: the kidney fire rushing down unrooted, treats the hectic fever due to YIN-deficiency having antiperspirant, only the heat of asthenia, the moon in tasteization source.Three's compatibility uses combined into monarch drug, energy Zishen fill fine, the cloudy insufficiency of essence of the kidney invigorating, treating YANG within YIN, and Liver and kidney is with mending simultaneously.The spleen being the foundation of acquired constitution, source of generating QI and blood, training is mended congenital be unableing to do without and is taken a tonic or nourishing food to build up one's health the day after tomorrow, and the kidney invigorating essence must fill blood, and could realize congenital posteriori alternate and change mutual use mutually, therefore in side, the Radix Paeoniae Alba enters liver, spleen channel, nourishing blood to suppress the hyperactive liver, and yin fluid astringing receives antiperspirant; The Rhizoma Atractylodis Macrocephalae bitter air making-up and spleen enlivening, dampness diuretic; Radix Ophiopogonis YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, and its taste is sweet greatly, and cream fat is strong, therefore specially mends stomach-Yin, grow body fluid, be originally sweet build up one's health by taking tonic benefit top grade; The Radix Rehmanniae is sweet, cold, GUIXIN, liver, kidney channel, clearing away heat and cooling blood, and yin nourishing, promotes the production of body fluid, the kidney invigorating water kidney-YIN being deficient; Rhizoma Acori Graminei is pungent, bitter, temperature, GUIXIN, stomach warp, and removing dampness is whetted the appetite, refreshment Fructus Alpiniae Oxyphyllae; Rhizoma Dioscoreae sweet in the mouth, returns spleen, lung, kidney channel, though gas temperature and putting down, spleen invigorating tonification, grow essence and reinforce the kidney, control all kinds of diseases and ailments, treat five kinds of strain and seven kinds of impairment, all medicines share as minister, strengthen the Zishen fill fine of monarch drug, effect of YIN nourishing and the production of body fluid promoting, simultaneously air making-up and spleen enlivening, moisturize, nourish heart.Help with Poria eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming, can mend five kinds of strain and seven kinds of impairment, antiabortive, warm waist knee joint, and happy Fructus Alpiniae Oxyphyllae is only forgetful; Flos Lonicerae: sweet, pungent, micro-hardship, cold, return lung, the heart, stomach large intestine channel, heat-clearing and toxic substances removing, pus is removed in removing toxic substances, and this product has benefit in rushing down; Radix Scrophulariae clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing.This thing bitter in the mouth and sweet, hardship can be relieved inflammation or internal heat, sweet can YIN nourishing, with its sweet in the mouth, therefore falling property is also delayed, and three medicines share beneficial invigorating the liver and kidney, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming, heat-clearing and toxic substances removing.Medicine Radix Glycyrrhizae property is put down, sweet in the mouth, invigorating the spleen and replenishing QI, relieving cough and moistening lung, emergency is detoxified, and is in harmonious proportion hundred medicines, tonification the five internal organs; Make all poison of drug; Support kidney qi internal injury, make us cloudy (no) flaccidity.Full side share has Zishen fill fine, and Liver and kidney is same to be mended, replenishing QI to invigorate the spleen, tranquilizing by nourishing the heart, effect of heat-clearing and toxic substances removing.
Advantage of the present invention:
1. prescription of the present invention is rigorous, and based on kidney tonifying, essence replenishing, warming and recuperating the kidney-YANG is auxiliary, equilibrium between yin and yang, on this basis regulating qi-flowing for strengthening spleen, tranquilizing by nourishing the heart, nourishing blood to suppress the hyperactive liver, reaches essence and blood gas and takes into account, and Liver and kidney heart spleen is with the effect of benefit.
2. reuse aminoacids complex in the present invention, nutritional labeling is combined with medicinal ingredient and plays synergism, strengthens the tonic effect of each composition, and enhance immunity of organisms, resisting fatigue, antioxidative effect, side effect is little.
3. prescription of the present invention is made up of 14 tastes, has no report, illustrate that the present invention has novelty at clinical and pertinent literature report.
4. kidney tonifying, essence replenishing pin of the present invention, not containing sucrose in pharmaceutical adjunct, has unique curative effect to diabetes, can long-term taking.
5. the present invention is component with Chinese medicine, and side effect is minimum, and does not cause drug dependence, takes safe and reliable and odorless, tasteless.
6. medical material composition of the present invention is simple, aboundresources.
7. the process route of invention formulation is simple, rationally, feasible.
Detailed description of the invention
The present invention is described further by clinical observation and embodiment, but scope of the present invention is not limited to following embodiment.
One, embodiment 1 and clinical observation on the therapeutic effect data
Embodiment 1 is made up of the raw material of following weight parts:
Aminoacids complex powder 300 parts, Fructus Lycii 200 parts, 90 parts, Poria, the Radix Paeoniae Alba 120 parts, the Rhizoma Atractylodis Macrocephalae 150 parts, Radix Ophiopogonis 120 parts, 60 parts, Radix Glycyrrhizae, 120 parts, the Radix Rehmanniae, Radix Scrophulariae 80 parts, the Cortex Eucommiae 200 parts, Flos Lonicerae 80 parts, the Rhizoma Anemarrhenae 180 parts, Rhizoma Acori Graminei 120 parts, Rhizomadioscoreae 150 parts.The preparation method of oral liquid, Fructus Lycii, Poria, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Radix Glycyrrhizae, the Radix Rehmanniae, Radix Scrophulariae, Flos Lonicerae, the Cortex Eucommiae, the Rhizoma Anemarrhenae, Rhizoma Acori Graminei and Rhizomadioscoreae is got by the weight proportion of prescription, add 8 times amount water soaking 45min, first time decoct 100min(wherein after Flos Lonicerae, Rhizoma Acori Graminei two taste medical material under), filter, filtering residue adds 6 times of water gagings to be continued to decoct 60min, filter, merging filtrate, concentrated, add Aminoacids complex powder, flavoring agent 0.2% aspartame and antiseptic 0.5% sodium benzoate, stir evenly, sterilizing, encapsulation, obtains oral liquid.
1, clinical physical data: for verifying the actual efficacy of medicine of the present invention, applies medicine of the present invention and coordinates clinical treatment insomnia, accept patient 100 example altogether for medical treatment, age distribution is as follows: less than 30 years old 24 example, 30-40 years old 26 example, 40-50 years old 22 example, 50-60 years old 18 examples, more than 60 years old 10 example; The oldest 70 years old, minimum 16 years old of age.
2, diagnosis index:
Clinical disease: soreness of the waist and knees, dysphoria with feverish sensation in the chest palms and soles, has a dizzy spell, tinnitus, hectic fever night sweat, osteopyrexia and fever, feverish sensation in the palms and soles, emaciated physique, insomnia forgetfulness, seminal emission, premature ejaculation, infrequent menstruation or amenorrhea, irritability, and tooth shakes,
And non-closure of fontanels jin infants, the few tongue of red tongue, thready and rapid pulse.
Usage and dosage: specification 15ml/ props up, one day 3; Or follow the doctor's advice.
3,3, Therapeutic Method: take above-mentioned Qi profit amino acids oral-liquor one day 3 or follow the doctor's advice, 7 days be a course for the treatment of, 2 courses for the treatment of reach rehabilitation substantially, consolidate and can reach curative effect 1-2 courses for the treatment of.
4, efficacy evaluation result
Clinical symptoms, the sign of clinical recovery syndrome of deficiency of kidney yin disappear or substantially disappear.
Clinical symptoms, the sign of effective syndrome of deficiency of kidney yin are improved substantially.
Clinical symptoms, the sign of effective syndrome of deficiency of kidney yin turn for the better by and large
Clinical symptoms, the sign of invalid syndrome of deficiency of kidney yin are not improved, and even increase the weight of
5, therapeutic outcome
By the conventional therapy of 2 courses for the treatment of, clinical recovery 40 example; Effective: 30 examples; Effective 20; Invalid 10 examples; Total effective rate 90%.
Again through 1-2 after treatments course for the treatment of, clinical recovery 50 example; Effective: 26 examples; Effective 19; Invalid 5 examples; Total effective rate 95%.
Two, in other embodiment
| Component | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 |
| Aminoacids complex powder | 250 parts | 350 parts | 250 parts | 350 parts | 320 parts |
| Fructus Lycii | 180 parts | 220 parts | 220 parts | 180 parts | 210 parts |
| Poria | 85 parts | 95 parts | 85 parts | 95 parts | 92 parts |
| The Radix Paeoniae Alba | 110 parts | 130 parts | 130 parts | 110 parts | 125 parts |
| The Rhizoma Atractylodis Macrocephalae | 120 parts | 160 parts | 120 parts | 160 parts | 130 parts |
| Radix Ophiopogonis | 110 parts | 130 parts | 130 parts | 110 parts | 115 parts |
| Radix Glycyrrhizae | 55 parts | 65 parts | 55 parts | 65 parts | 58 parts |
| The Radix Rehmanniae | 110 parts | 130 parts | 130 parts | 110 parts | 115 parts |
| Radix Scrophulariae | 70 parts | 90 parts | 70 parts | 90 parts | 85 parts |
| The Cortex Eucommiae | 180 parts | 220 parts | 220 parts | 180 parts | 190 parts |
| Flos Lonicerae | 70 parts | 90 parts | 70 parts | 90 parts | 85 parts |
| The Rhizoma Anemarrhenae | 160 parts | 200 parts | 200 parts | 160 parts | 175 parts |
| Rhizoma Acori Graminei | 100 parts | 140 parts | 100 parts | 140 parts | 135 parts |
| Rhizomadioscoreae | 140 parts | 160 parts | 160 parts | 140 parts | 145 parts |
The preparation method of oral liquid is with embodiment 1.
Claims (2)
1. a Qi profit amino acids oral-liquor for Zishen fill fine, is characterized in that being made up of the raw material of following weight parts:
Aminoacids complex powder 250-350 parts, Fructus Lycii 180-220 parts, 85-95 parts, Poria, the Radix Paeoniae Alba 110-130 parts, the Rhizoma Atractylodis Macrocephalae 120-160 parts, Radix Ophiopogonis 110-130 parts, 55-65 parts, Radix Glycyrrhizae, 110-130 parts, the Radix Rehmanniae, Radix Scrophulariae 70-90 parts, the Cortex Eucommiae 180-220 parts, Flos Lonicerae 70-90 parts, the Rhizoma Anemarrhenae 160-200 parts, Rhizoma Acori Graminei 100-140 parts, Rhizomadioscoreae 140-160 parts, Fructus Lycii is got by the weight proportion of prescription, Poria, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Radix Glycyrrhizae, the Radix Rehmanniae, Radix Scrophulariae, Flos Lonicerae, the Cortex Eucommiae, the Rhizoma Anemarrhenae, Rhizoma Acori Graminei and Rhizomadioscoreae, add 6-8 times amount water soaking 30min-60min, first time decocts 60-120min, filter, filtering residue adds 4-6 times of water gagings and continues decoction 60-90min, filter, merging filtrate, concentrated, add Aminoacids complex powder, flavoring agent aspartame and preservative sodium benzoate, stir evenly, sterilizing, encapsulation, obtain oral liquid.
2. the Qi profit amino acids oral-liquor of a kind of Zishen fill fine according to claim 1, is characterized in that being made up of the raw material of following weight parts:
Aminoacids complex powder 300 parts, Fructus Lycii 200 parts, 90 parts, Poria, the Radix Paeoniae Alba 120 parts, the Rhizoma Atractylodis Macrocephalae 150 parts, Radix Ophiopogonis 120 parts, 60 parts, Radix Glycyrrhizae, 120 parts, the Radix Rehmanniae, Radix Scrophulariae 80 parts, the Cortex Eucommiae 200 parts, Flos Lonicerae 80 parts, the Rhizoma Anemarrhenae 180 parts, Rhizoma Acori Graminei 120 parts, Rhizomadioscoreae 150 parts.
3. the Qi profit amino acids oral-liquor of a kind of Zishen fill fine according to claim 1 and 2, is characterized in that: when first time decocts, under after Flos Lonicerae, Rhizoma Acori Graminei two taste medical material.
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| CN1413629A (en) * | 2002-06-06 | 2003-04-30 | 孙克刚 | Oral liquid for nourishing yin and warming yang |
| CN101530551A (en) * | 2008-03-13 | 2009-09-16 | 北京天科仁祥医药科技有限公司 | Traditional Chinese medicine composition for nourishing yin and strengthening kidney and preparation method thereof |
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| CN1413629A (en) * | 2002-06-06 | 2003-04-30 | 孙克刚 | Oral liquid for nourishing yin and warming yang |
| CN101530551A (en) * | 2008-03-13 | 2009-09-16 | 北京天科仁祥医药科技有限公司 | Traditional Chinese medicine composition for nourishing yin and strengthening kidney and preparation method thereof |
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