CN108743810A - Chinese medicine composition and preparation method thereof for preventing senile dementia - Google Patents
Chinese medicine composition and preparation method thereof for preventing senile dementia Download PDFInfo
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- 206010039966 Senile dementia Diseases 0.000 title claims abstract description 18
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Abstract
The invention discloses a kind of Chinese medicine composition and preparation method thereof for preventing senile dementia, the preparation method includes：Huang Shi, sealwort, ginseng, Rhizoma Chuanxiong, matrimony vine, grass-leaved sweetflag, Herba Cistanches and water are mixed, decocts for the first time respectively later and second decocts, filtered fluid M is obtained after filtering；It is ground after rheum officinale, cordyceps sinensis, flower of kudzuvine, kadsura longepedunculata, Poria cocos, the stem of noble dendrobium, Eclipta prostrata, Radix Notoginseng and honeysuckle are mixed, obtains mixed-powder N；By tortoise-shell glue heating and melting, filtered fluid M and mixed-powder N is added later, obtains mixture A, the Chinese medicine composition is obtained after mixture A is sterilized, dry；The preparation method of the Chinese medicine composition of offer is simple, raw material is easy to get, while therapeutic effect is good, without side-effects.
Description
Technical field
The present invention relates to Chinese medicine compositions, and in particular, to it is a kind of for prevent senile dementia Chinese medicine composition and its
Preparation method.
Background technology
Alzheimer disease (AD) is a kind of nervous system degenerative disease of the progress sexual development of onset concealment.Clinically
With memory disorders, aphasia, appraxia, agnosia, the damage of visual space technical ability, execute dysfunction and personality and behavior change etc. comprehensively
Property dementia performance be characterized, the cause of disease is unknown so far.Patient was sent out before 65 years old, claimed alzheimer's disease；Hair patient claims always after 65 years old
Year property is dull-witted.Currently, the medicine type in clinical practice for senile dementia is fairly limited, it is exactly several small points substantially
Sub- chemicals are treated the conventional medicine of senile dementia and are largely directed into the drug of clinical three phases in the world at present
Single medicine target is intervened, and curative effect also carries out limited alleviation primarily with respect to the symptoms such as amnesia or nerve fiber degeneration
Compensation, therapeutic effect is very limited, and a kind of drug easily generates tolerance after a period of use, and alternative drugs lack
It is weary.Therefore currently there is an urgent need to develop the drug that can prevent, treat to significant effective even reverse disease progression, especially
Chinese medicine composition.
Invention content
The object of the present invention is to provide a kind of Chinese medicine compositions and preparation method thereof for preventing senile dementia, provide
The preparation method of Chinese medicine composition is simple, raw material is easy to get, while therapeutic effect is good, without side-effects.
To achieve the goals above, the present invention provides a kind of preparation sides for preventing the Chinese medicine composition of senile dementia
Method, the preparation method include：
(1) Huang Shi, sealwort, ginseng, Rhizoma Chuanxiong, matrimony vine, grass-leaved sweetflag, Herba Cistanches and water are mixed, is decocted for the first time respectively later
It boils and second decocts, filtered fluid M is obtained after filtering；
Wherein, the time decocted for the first time is 10-30min；Second of the time decocted is 40-50min；It decocts for the first time
Interval time between second of decoction is 20-25min；
(2) after rheum officinale, cordyceps sinensis, flower of kudzuvine, kadsura longepedunculata, Poria cocos, the stem of noble dendrobium, Eclipta prostrata, Radix Notoginseng and honeysuckle being mixed
It is ground, obtains mixed-powder N；
(3) by tortoise-shell glue heating and melting, filtered fluid M and mixed-powder N is added later, mixture A is obtained, by mixture A
The Chinese medicine composition is obtained after sterilized, dry.
It is described for preventing senile dementia the present invention also provides a kind of Chinese medicine composition for preventing senile dementia
Chinese medicine composition is made by above-mentioned preparation method.
Through the above technical solutions, the present invention provides a kind of preparation sides for preventing the Chinese medicine composition of senile dementia
Method, the preparation method include：Huang Shi, sealwort, ginseng, Rhizoma Chuanxiong, matrimony vine, grass-leaved sweetflag, Herba Cistanches and water are mixed, distinguished later
It decocts for the first time and second decocts, filtered fluid M is obtained after filtering；Wherein, the time decocted for the first time is 10-30min；Second
The time of secondary decoction is 40-50min；Interval time between decocting and decocting for the first time for second is 20-25min；By rheum officinale,
It is ground after cordyceps sinensis, flower of kudzuvine, kadsura longepedunculata, Poria cocos, the stem of noble dendrobium, Eclipta prostrata, Radix Notoginseng and honeysuckle mixing, obtains mixed powder
Last N；By tortoise-shell glue heating and melting, filtered fluid M and mixed-powder N is added later, obtains mixture A, mixture A is sterilized,
The Chinese medicine composition is obtained after drying；The preparation method of the Chinese medicine composition of offer is simple, raw material is easy to get, while the Chinese medicine group
The therapeutic effect for closing object is good, without side-effects.
Other features and advantages of the present invention will be described in detail in subsequent specific embodiment part.
Specific implementation mode
The specific implementation mode of the present invention is described in detail below.It should be understood that described herein specific
Embodiment is merely to illustrate and explain the present invention, and is not intended to restrict the invention.
The endpoint of disclosed range and any value are not limited to the accurate range or value herein, these ranges or
Value should be understood as comprising the value close to these ranges or value.For numberical range, between the endpoint value of each range, respectively
It can be combined with each other between the endpoint value of a range and individual point value, and individually between point value and obtain one or more
New numberical range, these numberical ranges should be considered as specific open herein.
The present invention provides a kind of preparation method for preventing the Chinese medicine composition of senile dementia, the preparation method packets
It includes：
(1) Huang Shi, sealwort, ginseng, Rhizoma Chuanxiong, matrimony vine, grass-leaved sweetflag, Herba Cistanches and water are mixed, is decocted for the first time respectively later
It boils and second decocts, filtered fluid M is obtained after filtering；
Wherein, the time decocted for the first time is 10-30min；Second of the time decocted is 40-50min；It decocts for the first time
Interval time between second of decoction is 20-25min；
(2) after rheum officinale, cordyceps sinensis, flower of kudzuvine, kadsura longepedunculata, Poria cocos, the stem of noble dendrobium, Eclipta prostrata, Radix Notoginseng and honeysuckle being mixed
It is ground, obtains mixed-powder N；
(3) by tortoise-shell glue heating and melting, filtered fluid M and mixed-powder N is added later, mixture A is obtained, by mixture A
The Chinese medicine composition is obtained after sterilized, dry.
In a kind of preferred embodiment of the present invention, the effect of in order to improve Chinese medicine composition, relative to 100 weight
The dosage of the water of part, Huang Shi is 10-15 parts by weight, and the dosage of sealwort is 5-8 parts by weight, and the dosage of ginseng is 2-6 parts by weight, river
The dosage of rhizome of chuanxiong is 1-7 parts by weight, and the dosage of matrimony vine is 2-7 parts by weight, and the dosage of grass-leaved sweetflag is 2-10 parts by weight, the use of Herba Cistanches
Amount is 1-6 parts by weight.
In a kind of preferred embodiment of the present invention, the effect of in order to improve Chinese medicine composition, relative to 100 weight
The dosage of the rheum officinale of part, cordyceps sinensis is 20-40 parts by weight, and the dosage of flower of kudzuvine is 8-12 parts by weight, and the dosage of kadsura longepedunculata is
The dosage of 2-8 parts by weight, Poria cocos is 10-20 parts by weight, and the dosage of the stem of noble dendrobium is 5-15 parts by weight, and the dosage of Eclipta prostrata is 2-9 weights
Part is measured, the dosage of Radix Notoginseng is 1-10 parts by weight, and the dosage of honeysuckle is 1-10 parts by weight.
In a kind of preferred embodiment of the present invention, the effect of in order to improve Chinese medicine composition, tortoise-shell glue, filtered fluid
M and mixed-powder N is 1 according to mass ratio:0.5-0.7:The ratio of 0.9-1.2 is mixed.
In a kind of preferred embodiment of the present invention, the effect of in order to improve Chinese medicine composition, in step (3),
The condition of sterilizing includes that temperature is 110-115 DEG C, time 5-10min.
In a kind of preferred embodiment of the present invention, the effect of in order to improve Chinese medicine composition, in step (3),
Dry condition includes：Pressure is -0.07Mpa~-0.06Mpa, and temperature is 60-80 DEG C, time 2-3h.
In a kind of preferred embodiment of the present invention, the effect of in order to improve Chinese medicine composition, mixed-powder N's is flat
Equal grain size is 2-4mm.
It is described for preventing senile dementia the present invention also provides a kind of Chinese medicine composition for preventing senile dementia
Chinese medicine composition is made by above-mentioned preparation method.
The present invention will be described in detail by way of examples below.
Embodiment 1
By Huang Shi, sealwort, ginseng, Rhizoma Chuanxiong, matrimony vine, grass-leaved sweetflag, Herba Cistanches and water mix, later respectively for the first time decoct and
Second of decoction, obtains filtered fluid M after filtering；Wherein, the time decocted for the first time is 10min；The time of decoction is for the second time
40min；Interval time between decocting and decocting for the first time for second is 20min；By rheum officinale, cordyceps sinensis, flower of kudzuvine, the southern five tastes
Son, Poria cocos, the stem of noble dendrobium, Eclipta prostrata, Radix Notoginseng and honeysuckle are 1 according to mass ratio:0.5:0.9 ratio is ground after being mixed
Mill, obtains mixed-powder N；By tortoise-shell glue heating and melting, filtered fluid M and mixed-powder N is added later, obtains mixture A, will mix
Close that object A sterilized (condition of sterilizing includes that temperature is 110 DEG C, time 5min), dry (dry condition includes：Pressure be-
0.07Mpa, temperature be 60 DEG C, time 2h) after obtain the Chinese medicine composition.Wherein, relative to the water of 100g, the use of Huang Shi
Amount is 10g, and the dosage of sealwort is 5g, and the dosage of ginseng is 2g, and the dosage of Rhizoma Chuanxiong is 1g, and the dosage of matrimony vine is 2g, grass-leaved sweetflag
Dosage is 2g, and the dosage of Herba Cistanches is 1g；Relative to the rheum officinale of 100g, the dosage of cordyceps sinensis is 20g, and the dosage of flower of kudzuvine is
The dosage of 8g, kadsura longepedunculata are 2g, and the dosage of Poria cocos is 10g, and the dosage of the stem of noble dendrobium is 5g, and the dosage of Eclipta prostrata is 2g, Radix Notoginseng
Dosage is 1g, and the dosage of honeysuckle is 1g.
Embodiment 2
By Huang Shi, sealwort, ginseng, Rhizoma Chuanxiong, matrimony vine, grass-leaved sweetflag, Herba Cistanches and water mix, later respectively for the first time decoct and
Second of decoction, obtains filtered fluid M after filtering；Wherein, the time decocted for the first time is 30min；The time of decoction is for the second time
50min；Interval time between decocting and decocting for the first time for second is 25min；By rheum officinale, cordyceps sinensis, flower of kudzuvine, the southern five tastes
Son, Poria cocos, the stem of noble dendrobium, Eclipta prostrata, Radix Notoginseng and honeysuckle are 1 according to mass ratio:0.7:1.2 ratio is ground after being mixed
Mill, obtains mixed-powder N；By tortoise-shell glue heating and melting, filtered fluid M and mixed-powder N is added later, obtains mixture A, will mix
Close that object A sterilized (condition of sterilizing includes that temperature is 115 DEG C, time 10min), dry (dry condition includes：Pressure
For -0.06Mpa, temperature is 80 DEG C, time 3h) after obtain the Chinese medicine composition.Wherein, relative to the water of 100g, Huang Shi
Dosage be 15g, the dosage of sealwort is 8g, and the dosage of ginseng is 6g, and the dosage of Rhizoma Chuanxiong is 7g, and the dosage of matrimony vine is 7g, stone Chang
The dosage of Pu is 10g, and the dosage of Herba Cistanches is 6g；Relative to the rheum officinale of 100g, the dosage of cordyceps sinensis is 40g, the use of flower of kudzuvine
Amount is 12g, and the dosage of kadsura longepedunculata is 8g, and the dosage of Poria cocos is 20g, and the dosage of the stem of noble dendrobium is 15g, and the dosage of Eclipta prostrata is 9g,
The dosage of Radix Notoginseng is 10g, and the dosage of honeysuckle is 10g.
Embodiment 3
By Huang Shi, sealwort, ginseng, Rhizoma Chuanxiong, matrimony vine, grass-leaved sweetflag, Herba Cistanches and water mix, later respectively for the first time decoct and
Second of decoction, obtains filtered fluid M after filtering；Wherein, the time decocted for the first time is 20min；The time of decoction is for the second time
45min；Interval time between decocting and decocting for the first time for second is 22min；By rheum officinale, cordyceps sinensis, flower of kudzuvine, the southern five tastes
Son, Poria cocos, the stem of noble dendrobium, Eclipta prostrata, Radix Notoginseng and honeysuckle are 1 according to mass ratio:0.6:1 ratio is ground after being mixed,
Obtain mixed-powder N；By tortoise-shell glue heating and melting, filtered fluid M and mixed-powder N is added later, obtains mixture A, will mix
Object A sterilized (condition of sterilizing includes that temperature is 112 DEG C, time 7min), dry (dry condition includes：Pressure be-
0.06Mpa, temperature be 70 DEG C, time 2.5h) after obtain the Chinese medicine composition.Wherein, relative to the water of 100g, Huang Shi's
Dosage is 12g, and the dosage of sealwort is 7g, and the dosage of ginseng is 4g, and the dosage of Rhizoma Chuanxiong is 4g, and the dosage of matrimony vine is 4.5g, stone Chang
The dosage of Pu is 6g, and the dosage of Herba Cistanches is 3.5g；Relative to the rheum officinale of 100g, the dosage of cordyceps sinensis is 30g, the use of flower of kudzuvine
Amount is 10g, and the dosage of kadsura longepedunculata is 5g, and the dosage of Poria cocos is 15g, and the dosage of the stem of noble dendrobium is 10g, and the dosage of Eclipta prostrata is
The dosage of 5.5g, Radix Notoginseng are 5.5g, and the dosage of honeysuckle is 5.5g.
Chinese medicine composition made from embodiment 3 is used for clinical treatment, and carries out clinical observation：
The patients of senile dementia 100 made a definite diagnosis is randomly selected.Wherein, male patient 66, female patient 34,
Age 60-80 Sui, course of disease 1-3.
Therapy：
Using the Chinese medicine composition prepared by the embodiment of the present invention 3, each two panels, three times a day, every content of dispersion 0.25
Gram, half an hour warm water delivery service, avoids pungent greasy object, avoids tobacco and wine after meal；Pregnant woman uses with caution.
Efficacy assessment standard：
It cures：Knowing reduces with memory function decline, social adaptation, and the symptoms such as various mental symptoms and behavior disorder disappear
Lose, more after do not recur, restore normal life completely.
Effectively：Above-mentioned symptom is substantially reduced, and disease cycle increases, and returns to normal life.
It is effective：Above-mentioned symptom mitigates.
In vain：Comparison is checked before and after treatment, and symptom, sign are unchanged.
Case 1, Mr. Wang, male, 71 years old.With symptoms such as failure of memory, insomnia forgetfulness, the embodiment of the present invention is continuously taken
The symptom mitigation after 1 month of 3 gained Chinese medicine compositions, symptom disappears after then taking 2 months, is discontinued after continuing medication 3 months, with
Visit is not recurred.
Case 2, week certain, female, 62 years old.With lather, kick up a great deal of fuss about, it is suspicious to worry too much, it cannot independently carry out outgoing work
Symptoms, once used several western medicines in treatment, the effect such as dynamic are undesirable.Medication process and effect：Take 3 institute of the embodiment of the present invention
Chinese medicine composition symptom mitigation after 1 month is obtained, symptom disappears after then taking 6 months, is discontinued, and follow-up is not recurred.
Case 3, Zhu, female, 68 years old.Have, unstable on foot, hemiplegia, the symptoms such as gatism once repeatedly toss about training
Hospital's unsatisfactory curative effect.Medication process and effect：The symptom mitigation after 2 months of 3 gained Chinese medicine composition of the embodiment of the present invention is taken, with
After take 6 months after symptom disappear, continue medication 3 months after be discontinued, follow-up is not recurred.
The preferred embodiment of the present invention has been described above in detail, still, during present invention is not limited to the embodiments described above
Detail can carry out a variety of simple variants to technical scheme of the present invention within the scope of the technical concept of the present invention, this
A little simple variants all belong to the scope of protection of the present invention.
It is further to note that specific technical features described in the above specific embodiments, in not lance
In the case of shield, can be combined by any suitable means, in order to avoid unnecessary repetition, the present invention to it is various can
The combination of energy no longer separately illustrates.
In addition, various embodiments of the present invention can be combined randomly, as long as it is without prejudice to originally
The thought of invention, it should also be regarded as the disclosure of the present invention.
Claims (8)
1. a kind of preparation method for preventing the Chinese medicine composition of senile dementia, which is characterized in that the preparation method includes：
(1) by Huang Shi, sealwort, ginseng, Rhizoma Chuanxiong, matrimony vine, grass-leaved sweetflag, Herba Cistanches and water mix, later respectively for the first time decoct and
Second of decoction, obtains filtered fluid M after filtering；
Wherein, the time decocted for the first time is 10-30min；Second of the time decocted is 40-50min；It decocts for the first time and the
Interval time between secondary decoction is 20-25min；
(2) it is carried out after mixing rheum officinale, cordyceps sinensis, flower of kudzuvine, kadsura longepedunculata, Poria cocos, the stem of noble dendrobium, Eclipta prostrata, Radix Notoginseng and honeysuckle
Grinding, obtains mixed-powder N；
(3) by tortoise-shell glue heating and melting, filtered fluid M and mixed-powder N is added later, mixture A is obtained, by mixture A through going out
The Chinese medicine composition is obtained after bacterium, drying.
2. preparation method according to claim 1, wherein relative to the water of 100 parts by weight, the dosage of Huang Shi is 10-15
The dosage of parts by weight, sealwort is 5-8 parts by weight, and the dosage of ginseng is 2-6 parts by weight, and the dosage of Rhizoma Chuanxiong is 1-7 parts by weight, matrimony vine
Dosage be 2-7 parts by weight, the dosage of grass-leaved sweetflag is 2-10 parts by weight, and the dosage of Herba Cistanches is 1-6 parts by weight.
3. preparation method according to claim 1, wherein relative to the rheum officinale of 100 parts by weight, the dosage of cordyceps sinensis is
The dosage of 20-40 parts by weight, flower of kudzuvine is 8-12 parts by weight, and the dosage of kadsura longepedunculata is 2-8 parts by weight, and the dosage of Poria cocos is 10-
The dosage of 20 parts by weight, the stem of noble dendrobium is 5-15 parts by weight, and the dosage of Eclipta prostrata is 2-9 parts by weight, and the dosage of Radix Notoginseng is 1-10 weight
Part, the dosage of honeysuckle is 1-10 parts by weight.
4. preparation method according to claim 1, wherein tortoise-shell glue, filtered fluid M and mixed-powder N are according to mass ratio
1:0.5-0.7:The ratio of 0.9-1.2 is mixed.
5. preparation method according to claim 1, wherein in step (3), it is 110- that the condition of sterilizing, which includes temperature,
115 DEG C, time 5-10min.
6. preparation method according to claim 1, wherein in step (3), dry condition includes：Pressure be-
0.07Mpa~-0.06Mpa, temperature are 60-80 DEG C, time 2-3h.
7. preparation method according to claim 1, wherein the average grain diameter of mixed-powder N is 2-4mm.
8. a kind of Chinese medicine composition for preventing senile dementia, which is characterized in that the Chinese medicine for preventing senile dementia
Composition is made by the preparation method described in any one of claim 1-7.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102240380A (en) * | 2011-06-13 | 2011-11-16 | 许建成 | Traditional Chinese medicine preparation for treating senile vascular dementia |
| CN105521306A (en) * | 2015-12-09 | 2016-04-27 | 贵州神奇药物研究院 | Traditional Chinese medicine composition |
| CN107126508A (en) * | 2017-05-09 | 2017-09-05 | 巩萍 | A kind of pharmaceutical composition for preventing and treating senile dementia and preparation method thereof |
| CN108837080A (en) * | 2018-07-19 | 2018-11-20 | 芜湖福民生物药业股份有限公司 | Chinese medicine composition and preparation method thereof containing huperzine |
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2018
- 2018-07-13 CN CN201810767568.4A patent/CN108743810A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102240380A (en) * | 2011-06-13 | 2011-11-16 | 许建成 | Traditional Chinese medicine preparation for treating senile vascular dementia |
| CN105521306A (en) * | 2015-12-09 | 2016-04-27 | 贵州神奇药物研究院 | Traditional Chinese medicine composition |
| CN107126508A (en) * | 2017-05-09 | 2017-09-05 | 巩萍 | A kind of pharmaceutical composition for preventing and treating senile dementia and preparation method thereof |
| CN108837080A (en) * | 2018-07-19 | 2018-11-20 | 芜湖福民生物药业股份有限公司 | Chinese medicine composition and preparation method thereof containing huperzine |
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