CN105521306A - Traditional Chinese medicine composition - Google Patents
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- CN105521306A CN105521306A CN201510906830.5A CN201510906830A CN105521306A CN 105521306 A CN105521306 A CN 105521306A CN 201510906830 A CN201510906830 A CN 201510906830A CN 105521306 A CN105521306 A CN 105521306A
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Abstract
The invention relates to a traditional Chinese medicine composition and a drug containing the same. The traditional Chinese medicine composition is prepared from traditional Chinese medicine components of radix ginseng, lucid ganoderma, radix astragali, radix ophiopogonis, herba dendrobii, radix polygalae, rhizoma acori tatarinowii, pumice, rhizoma gastrodiae, radix angelicae sinensis, leech, rhizoma ligustici, dragon bone, tortoise plastron, stir-fried spiny jujube, rhizoma polygonati, chinese wolfberry fruit, herba epimedii, sliced processed aconite and placenta hominis. The traditional Chinese medicine composition selects and uses natural Chinese herbal medicines as raw materials, has a good health function on a human body, is small in side effect, and achieves the purposes of preventing senile dementia and warding off diseases to build bodies.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and comprise the pharmaceutical preparation of this Chinese medicine composition.
Background technology
Senile dementia means and occurs in senile various chronic brain syndrome, is a kind of with the degeneration of brain, and brain cell atrophy, cerebrovascular hemorrhage, cerebrovascular chronic hypoxia etc. are the dull-witted syndrome of pathologic basis.Show as hypomnesis caused by cognitive decrease, behavior postpones, exercise not harmony.Its main pathological characters occurs a large amount of senile plaque, neurofibrillary tangles, amyloid beta deposition and neuron vacuolar degeneration in brain and loses in a large number.
The medicament categories of current treatment senile dementia is also many, and a class increases brain Cholinergic nervous function, is mainly cholinesterase inhibitor and M-cholinergic receptor agonist.The another kind of cytoprotective for acting on neuronal transmission system, to delay neuronal degeneration process, comprises antioxidant, NSAID (non-steroidal anti-inflammatory drug), neurotrophic factor, anti-neuronal apoptosis agent and short neuron metabolism medicine, calcium channel blocking etc.Although above-mentioned this two large class medicine said can improve alleviate senile dementia clinical symptoms, disease can not be cured completely.
The aging increasingly of current China, so the sickness rate of senile dementia will improve constantly, also increasing on the impact of society, badly influence the development of society.Therefore, this disease is not when effecting a radical cure, and the medicine that exploitation can prevent and treat senile dementia is particularly important.
At present, quite a few to the bibliographical information such as the health product comprising plant amedica, medicine, food for the treatment of senile dementia aspect, the Chinese medicine composition (number of patent application 201510062471.X) for the treatment of senile dementia as a kind of is made up of 12 taste medicines such as Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Acori Graminei, Radix Ginseng, the Radix Astragali, Ganoderma, Radix Glycyrrhizaes; If brain-tonifying intelligence-raising granules (number of patent application 01121542.9) is prepared from by 16 taste medicines such as Fructus Lycii, Radix Ginseng, the Radix Astragali, Herba Epimedii, Fructus Jujubae, Rhizoma Polygonati, Hirudo, Semen Juglandis, Fructus Alpiniae Oxyphyllae; Nourishing the brain and improving intelligence ball and preparation method thereof (number of patent application 201310022390.8) is prepared from by 11 taste medicines such as vinegar Carapax et Plastrum Testudinis, Os Draconis, Radix Ophiopogonis, Radix Polygalae, Semen Ziziphi Spinosae (parched), Rhizoma Chuanxiong, Radix Rehmanniaes Preparata.Technique scheme is mainly tended to improve the functions such as memory, thus alleviates senile dementia symptom, belongs to symptomatic treatment, takes stopgap measures and does not make this.In addition, inventor finds when studying, and the Chinese medicine compound of a lot for the treatment of senile dementia has no report.
Summary of the invention
The object of this invention is to provide that a kind of good effect, toxic and side effects are little, the Chinese medicine composition for the treatment of both the principal and secondary aspects of a disease and comprise the pharmaceutical preparation of said composition, this pharmaceutical preparation can prevent and treat senile dementia.
The present invention also aims to provide above-mentioned composition for preventing and treating the purposes of senile dementia.
In order to achieve the above object, the invention provides a kind of Chinese medicine composition, said composition is made up of the Chinese medicinal components of following weight portion:
Radix Ginseng 27 ~ 30 parts, Ganoderma 30 ~ 36 parts, the Radix Astragali 30 ~ 36 parts, Radix Ophiopogonis 15 ~ 36 parts, Sichuan Herba Dendrobii 20 ~ 36 parts, Radix Polygalae 15 ~ 27 parts, Rhizoma Acori Graminei 20 ~ 27 parts, Pumex 25 ~ 45 parts, 30 ~ 35 parts, Rhizoma Gastrodiae, Radix Angelicae Sinensis 30 ~ 36 parts, Hirudo 9 ~ 12 parts, Rhizoma Chuanxiong 20 ~ 27 parts, Os Draconis 90 ~ 96 parts, Carapax et Plastrum Testudinis 60 ~ 72 parts, Semen Ziziphi Spinosae (parched) 45 ~ 50 parts, Rhizoma Polygonati 45 ~ 50 parts, Fructus Lycii 30 ~ 36 parts, Herba Epimedii 40 ~ 45 parts, Radix Aconiti Lateralis Preparata 15 ~ 20 parts, Placenta Hominis 20 ~ 30 parts.
Preferably: Radix Ginseng 29 parts, Ganoderma 33 parts, the Radix Astragali 33 parts, Radix Ophiopogonis 30 parts, Sichuan Herba Dendrobii 28 parts, Radix Polygalae 20 parts, Rhizoma Acori Graminei 24 parts, Pumex 30 parts, 32 parts, Rhizoma Gastrodiae, Radix Angelicae Sinensis 34 parts, Hirudo 10 parts, Rhizoma Chuanxiong 25 parts, Os Draconis 92 parts, Carapax et Plastrum Testudinis 65 parts, Semen Ziziphi Spinosae (parched) 48 parts, Rhizoma Polygonati 47 parts, Fructus Lycii 32 parts, Herba Epimedii 42 parts, Radix Aconiti Lateralis Preparata 18 parts, Placenta Hominis 22 parts.
The present invention also provides a kind of pharmaceutical preparation preventing and treating senile dementia, and be made up of above-mentioned Chinese medicine composition and the acceptable adjuvant of pharmacy, the dosage form of described pharmaceutical preparation is the regular dosage form in pharmaceutics.
The pharmaceutical preparation of above-mentioned control senile dementia is preferably peroral dosage form, comprises granule, tablet, capsule, sweet unguentum.
The preparation method of described granule, comprises the following steps:
1) Traditional Chinese medicine composition formula amount component is taken respectively;
2) Radix Ginseng, Ganoderma, Pumex, Rhizoma Gastrodiae, Rhizoma Chuanxiong, Os Draconis, Carapax et Plastrum Testudinis, Rhizoma Polygonati are ground into granule, Placenta Hominis cut into slices, with residue ten simply medical material decoct with water three times, first time 2 ~ 2.5h, second time 1.5 ~ 2h, third time 1 ~ 1.5h, merges three filtrates;
3) gained filtrate concentrated, when obtaining 80 DEG C, relative density is the clear paste of 1.25 ~ 1.30;
4) add mannitol or dextrin, mixing, granulate, dry, granulate, to obtain final product.
The preparation method of described tablet is got in above-mentioned process for producing granula through 1) ~ 3) the obtained clear paste of step, add sorbitol, carboxymethyl starch sodium, mixing, granulate, dry, then add magnesium stearate, mixing, tabletting, to obtain final product.
The preparation method of described capsule is got in above-mentioned process for producing granula through 1) ~ 3) the obtained clear paste of step, add pregelatinized Starch, dry, pulverize, sieve, add micropowder silica gel or magnesium stearate, mixing, incapsulates, to obtain final product.
The preparation method of described sweet unguentum is got in above-mentioned process for producing granula through 1), 2) the obtained filtrate of step, gained filtrate concentrated, when obtaining 80 DEG C, relative density is the clear paste of 1.18 ~ 1.22, and filter, add refined honey, simmer down to thick paste, to obtain final product.
Preferably: described thick paste relative density at 80 DEG C is 1.30 ~ 1.35.
The present invention adopt raw material, effect and mechanism as follows:
Radix Ginseng: the sweet micro-hardship of property, temperature; Return spleen, lung meridian.There is strongly invigorating primordial QI, promote the production of body fluid Gu de-, effect of calming the nerves.Control impairment caused by overstrain deficient, lack of appetite, asthenia, palpitation with fear, forgetful, dizziness and headache, quenches one's thirst, and prolonged deficiency is not multiple, the card of all qi-blood-body fluid deficiencies.
Ganoderma: warm in nature, lightly seasoned.There is strengthening by means of tonics effect.For brain-strengthening, antiinflammatory, diuresis, kidney tonifying etc.
The Radix Astragali: warm in nature, sweet in the mouth.There is invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, diuresis, granulation promoting effect., spontaneous perspiration, edema, chronic nephritis proteinuria, diabetes etc. weak for the deficiency of vital energy.
Radix Ophiopogonis: property is sweet, micro-hardship, is slightly cold; GUIXIN, lung, stomach warp.Have YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire effect.For YIN nourishing and the production of body fluid promoting, dryness of the lung dry cough, chronic consumptive disease is coughed, and Tianjin wound is thirsty, and vexed insomnia, interior-heat is quenched one's thirst.
Sichuan Herba Dendrobii: sweet in the mouth is put down.Main damaging the spleen and stomach, eliminating impediment, the therapeutic method to keep the adverse QI flowing downwards, tonifying five ZANG-organs asthenia weakness and emaciation, reinforcing YIN-essence, takes thick the intestines and stomach for a long time, makes light of one's life by commiting suicide and prolong life.
Radix Polygalae: property toil, temperature; Enter the heart, kidney channel.There is Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm and have one's ideas straightened out, melancholy-relieving effect.Control palpitation with fear, forgetful, eliminate the phlegm, for the insomnia of the coma abundant expectoration of phlegmatic mental confusion, Mental Subnormality and disarmony between the heart and kidney.
Rhizoma Acori Graminei: property is pungent, tepor; Entrance, liver, spleen channel.Have and have one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae, eliminating phlegm, regulate the flow of vital energy, and invigorates blood circulation, loose wind, effect of drying.Control epilepsy, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, anemofrigid-damp arthralgia etc.
Pumex: property is salty, cold; Enter lung, kidney channel.There is lung heat clearing fire, change old expectorant, softening the hard mass, treating stranguria effect.Control expectorant dyspnea of heat type to cough, old accumulation of phlegm block, hernia, skin ulcer swells, corneal nebula etc.
Rhizoma Gastrodiae: property is sweet is flat; Enter Liver Channel.There is endogenous wind stopping, arresting convulsion effect.Control dizzy pupil, wind syndrome of head is had a headache, numb limbs and tense tendons, hemiplegia, aphasia, pediatric epilepsy scared wind symptom etc.
Radix Angelicae Sinensis: property is sweet, Xin Wen; Enter the heart, liver, spleen channel.There is benefiting blood and regulating blood circulation, pain relieving, moisturize laxation effect.Control amenorrhea stomachache, headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine dyschezia, after bloody dysentery heavily etc.
Hirudo: the salty hardship of property, flat; Enter liver, urinary bladder channel.There is removing blood stasis, removing blood stasis, effect of stimulating the menstrual flow.Control blood-retention, abdominal mass, gather, blood stasis becomes consumptive disease, injury from falling down, and order is pain also, nebula etc.
Rhizoma Chuanxiong: property is pungent, temperature; Enter liver, gallbladder meridian.Have activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain effect.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, for abdominal mass stomachache, and the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia etc.
Os Draconis: property is sweet puckery are flat; Enter the heart, liver, kidney, large intestine channel.There is tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing effect.Control infantile convulsion demented, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, spontaneous sweating, tells nosebleed and has blood in stool, dysentery proctoptosis etc.
Carapax et Plastrum Testudinis: property is salty sweet.There is YIN nourishing, YANG hyperactivity suppressing, the kidney invigorating, strong bone effect.Control deficiency of kidney yin, hectic fever due to YIN-deficiency consumptive fever, spit blood, epistaxis, chronic cough, lumbago, the atrophic debility of bones, stirring of wind due to deficiency of YIN, chronic dysentery, chronic malaria etc.
Semen Ziziphi Spinosae (parched): sweet in the mouth, acid, property is put down.Can nourish conscience, calm the nerves, beneficial will is breathed out surely, hearing-improing and eyesight improving, arresting sweating.Control restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility etc.
Rhizoma Polygonati: property is sweet is flat; Enter spleen, lung, kidney channel.There is invigorating the spleen and replenishing QI, profit cardiopulmonary, bone and muscle strengthening effect.Control deficient cold and heat, pulmonary tuberculosis hemoptysis, after being ill the empty lack of appetite of body, muscles and bones is weak, rheumatalgia, wind favus disease etc.
Fructus Lycii: property is sweet is flat; Enter liver, kidney channel.There is nourishing kidney, lung moistening, tonifying liver, improving eyesight effect.Control hepatic and renal YIN deficiency, soreness of the waist and knees, dizzy, dizzy, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst.
Herba Epimedii: property is pungent sweet, temperature; Enter liver, kidney channel.There is kidney invigorating and YANG supporting, expelling wind and removing dampness effect.Control muscles and bones contraction anxious, hemiplegia, weakness of the waist and knees, rheumatic arthralgia, extremity are meciless.
Radix Aconiti Lateralis Preparata: property is pungent, sweet is warm greatly, poisonous; GUIXIN, kidney, spleen channel.There is recuperating depleted YANG and rescuing the patient from collapse, mend fire supporing yang, by wind-cold damp pathogen effect.For YANG-depletion collapse, cold extremities faint pulse, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, arthralgia due to cold-dampnes etc.
Placenta Hominis: property is sweet salty, temperature; Enter lung, liver, kidney channel.There is QI invigorating, nourish blood, beneficial smart effect.Control deficient, weakness and emaciation, consumptive fever hectic fever due to YIN-deficiency, cough with asthma, spitting of blood, night sweat, vim and vigour are not enough.
The present invention selects natural Chinese medicinal herb to be raw material, harmless to human non-toxic, has no side effect.
Prescription of the present invention meets theory of Chinese medical science, focuses on QI and blood regulating, brain, the heart, kidney be integrated, and has effect that complement kidney tonifying, refreshment, QI and blood are unobstructed.The traditional Chinese medical science is thought, people easily has a sleepless night, forgetful, senile dementia, is with insufficiency of vital energy and blood, caused by heart kidney deficiency.Its position forgetful and dull-witted in brain, main disease at kidney, closely related with liver, spleen.Prevention and therapy is forgetful, senile dementia, should nourish blood, kidney calming, Fructus Alpiniae Oxyphyllae of calming the nerves, adjusts and reach battalion and defend as the rule for the treatment of with benefit institute.Therefore, take Chinese medicine composition of the present invention for a long time, people can be made energetic, reach the object of control senile dementia, disease-relieving and physique enhancing.
Detailed description of the invention
Further describe technical scheme of the present invention below, but described in claimed scope is not limited to.Below in conjunction with specific embodiment, elaboration detailed is further done to the present invention, but embodiments of the present invention are not limited to the scope that embodiment represents.These embodiments only for illustration of the present invention, but not for limiting the scope of the invention.In addition, after reading content of the present invention, those skilled in the art can do various amendment to the present invention, and these equivalent variations fall within appended claims limited range of the present invention equally.
Embodiment 1: the preparation of control senile dementia Chinese medicine composition honey unguentum:
Raw material is got according to following weight (gram) proportioning:
Radix Ginseng 27 Ganoderma 30 Radix Astragali 30 Sichuan Herba Dendrobii 20 Radix Ophiopogonis 15 Radix Polygalae 15 Rhizoma Acori Graminei 20 Pumex 25 Rhizoma Gastrodiae 30 Radix Angelicae Sinensis 30 Hirudo 9 Rhizoma Chuanxiong 20 Os Draconis 90 Carapax et Plastrum Testudinis 60 Semen Ziziphi Spinosae (parched) 45 Rhizoma Polygonati 45 Fructus Lycii 30 Herba Epimedii 40 Radix Aconiti Lateralis Preparata 15 Placenta Hominis 20.
Radix Ginseng, Ganoderma, Pumex, Rhizoma Gastrodiae, Rhizoma Chuanxiong, Os Draconis, Carapax et Plastrum Testudinis, Rhizoma Polygonati are ground into coarse granule, Placenta Hominis cut into slices, with above-mentioned ten simply medical material add 8 times of soak by water three times, first time 2h, second time 1.5h, third time 1h, merge three filtrates, filtrate is concentrated into the clear paste that relative density is 1.18 (80 DEG C), filters, and it is appropriate to add refined honey, mixing, heating is concentrated into the thick paste that relative density is 1.30 (80 DEG C), makes 1000g, to obtain final product.Specification: every bottled 250g, usage and dosage: oral each 5-10g.
Embodiment 2: the preparation of control senile dementia Chinese medicinal composition granules:
Raw material is got according to following weight (gram) proportioning:
Radix Ginseng 29 Ganoderma 33 Radix Astragali 33 Sichuan Herba Dendrobii 28 Radix Ophiopogonis 30 Radix Polygalae 20 Rhizoma Acori Graminei 24 Pumex 30 Rhizoma Gastrodiae 32 Radix Angelicae Sinensis 34 Hirudo 10 Rhizoma Chuanxiong 25 Os Draconis 92 Carapax et Plastrum Testudinis 65 Semen Ziziphi Spinosae (parched) 48 Rhizoma Polygonati 47 Fructus Lycii 32 Herba Epimedii 42 Radix Aconiti Lateralis Preparata 18 Placenta Hominis 22.
Radix Ginseng, Ganoderma, Pumex, Rhizoma Gastrodiae, Rhizoma Chuanxiong, Os Draconis, Carapax et Plastrum Testudinis, Rhizoma Polygonati are ground into coarse granule, Placenta Hominis cut into slices, with above-mentioned ten simply medical material add 7 times of soak by water three times, first time 2h, second time 1.5h, third time 1h, and three filtrate, filtrate is concentrated into the clear paste that relative density is 1.25 (80 DEG C), adds mannitol or dextrin to total amount 5000g, mixing, granulate, drying, granulate, to obtain final product.Specification: often packed 5 grams.Usage and dosage: oral, each one bag, once a day.
Embodiment 3: the preparation of control senile dementia Chinese medicine composition tablet:
Raw material is got according to following weight (gram) proportioning:
Radix Ginseng 30 Ganoderma 36 Radix Astragali 36 Sichuan Herba Dendrobii 36 Radix Ophiopogonis 36 Radix Polygalae 27 Rhizoma Acori Graminei 27 Pumex 45 Rhizoma Gastrodiae 35 Radix Angelicae Sinensis 36 Hirudo 12 Rhizoma Chuanxiong 27 Os Draconis 96 Carapax et Plastrum Testudinis 72 Semen Ziziphi Spinosae (parched) 50 Rhizoma Polygonati 50 Fructus Lycii 36 Herba Epimedii 45 Radix Aconiti Lateralis Preparata 20 Placenta Hominis 30.
Ginseng and lucid ganoderma, Pumex, Rhizoma Gastrodiae, Rhizoma Chuanxiong, Os Draconis, Carapax et Plastrum Testudinis, Rhizoma Polygonati are ground into coarse granule, Placenta Hominis is cut into slices, with above-mentioned ten simply medical material add suitable quantity of water and decoct three times, first time 2h, second time 1.5h, third time 1h, merges three filtrate, filtrate is concentrated into the clear paste that relative density is 1.25 (80 DEG C), add sorbitol and carboxymethyl starch sodium (weight ratio 1:2), to total amount 500g, mixing, granulate, drying, then the magnesium stearate adding total amount 0.5%, mixing, tabletting, obtains 1000, tablet.Specification: 0.5 gram/piece, usage and dosage: oral, each a slice, once a day.
Embodiment 4: the preparation of control senile dementia Chinese medicinal composition capsules agent:
Raw material is got according to following weight (gram) proportioning:
Radix Ginseng 30 Ganoderma 30 Radix Astragali 30 Sichuan Herba Dendrobii 20 Radix Ophiopogonis 15 Radix Polygalae 15 Rhizoma Acori Graminei 20 Pumex 25 Rhizoma Gastrodiae 30 Radix Angelicae Sinensis 30 Hirudo 9 Rhizoma Chuanxiong 20 Os Draconis 90 Carapax et Plastrum Testudinis 60 Semen Ziziphi Spinosae (parched) 50 Rhizoma Polygonati 45 Fructus Lycii 30 Herba Epimedii 40 Radix Aconiti Lateralis Preparata 15 Placenta Hominis 30.
Above-mentioned Radix Ginseng, Ganoderma, Pumex, Rhizoma Gastrodiae, Rhizoma Chuanxiong, Os Draconis, Carapax et Plastrum Testudinis, Rhizoma Polygonati are ground into coarse granule respectively, Placenta Hominis is cut into slices, with above-mentioned ten simply medical material add suitable quantity of water and decoct three times, first time 2h, second time 1.5h, third time 1h, merges three filtrate, filtrate is concentrated into the clear paste that relative density is 1.25 (80 DEG C), add pregelatinized Starch to total amount 1000g, mixing, 80 DEG C of dryings, pulverize, 80 orders sieve, and add micropowder silica gel or the magnesium stearate of total amount 0.5%, mixing, fill, obtain capsule.Specification: 0.5 gram/, usage and dosage: oral, each 2, once a day.
Embodiment 5: the preparation of control senile dementia Chinese medicine composition honey unguentum:
On the basis of embodiment 1, other are all with embodiment 1, wherein, the preparation method of this sweet unguentum is: required medical material is decocted with water three times, and first time decocts 2.5h, and second time decocts 2h, third time decocts 1.5h, and merge three filtrates, filtrate is concentrated into the clear paste that relative density is 1.22 (80 DEG C), filter, add refined honey appropriate, mixing, heating is concentrated into the thick paste that relative density is 1.35 (80 DEG C), make 1000g, to obtain final product.Specification: every bottled 250g, usage and dosage: oral each 5-10g.
Embodiment 6: the preparation of control senile dementia Chinese medicinal composition granules:
On the basis of embodiment 2, other are all with embodiment 2, wherein, the preparation method of this granule is: required medical material is decocted with water three times, and first time decocts 2.5h, and second time decocts 2h, third time decocts 1.5h, and merge three filtrates, filtrate is concentrated into the clear paste that relative density is 1.3 (80 DEG C), add mannitol or dextrin to total amount 5000g, mixing, granulates, dry, granulate, to obtain final product.Specification: often packed 5 grams; Usage and dosage: oral, each one bag, once a day.
Embodiment 7: the preparation of control senile dementia Chinese medicine composition tablet:
On the basis of embodiment 3, other are all with embodiment 3, wherein, the preparation method of this sweet unguentum is: required medical material is decocted with water three times, and first time decocts 2.5h, and second time decocts 2h, third time decocts 1.5h, merge three filtrates, filtrate is concentrated into the clear paste that relative density is 1.3 (80 DEG C), adds sorbitol and carboxymethyl starch sodium (weight ratio 1:2), to total amount 500g, mixing, granulates, dry, add the magnesium stearate of total amount 0.5% again, mixing, tabletting, obtains 1000, tablet.Specification: 0.5 gram/piece, usage and dosage: oral, each a slice, once a day.
Embodiment 8: the preparation of control senile dementia Chinese medicinal composition capsules agent:
On the basis of embodiment 4, other are all with embodiment 4, wherein, the preparation method of this sweet unguentum is: required medical material is decocted with water three times, and first time decocts 2.5h, and second time decocts 2h, third time decocts 1.5h, and merge three filtrates, filtrate is concentrated into the clear paste that relative density is 1.3 (80 DEG C), add pregelatinized Starch to total amount 1000g, mixing, 80 DEG C of dryings, pulverize, 80 orders sieve, and add micropowder silica gel or the magnesium stearate of total amount 0.5%, mixing, fills, obtains capsule.Specification: 0.5 gram/, usage and dosage: oral, each 2, once a day.
Experimental example 1: the clinical research of senile dementia prevention and cure Chinese medicine composition of the present invention:
1 data and method
1.1 clinical data
Random selecting 350 example suffers from the patient of senile dementia, wherein male account for 217 example, women account for 133 example, the age 60-90 year between, through 72.6 years old statistical average age; The clinical manifestation of patient is cognitive disorder 228 example, computing capability differs from 181 examples, apathetic expression, bradykinesia 157 example, speech disorder 113 is routine, and thought disturbance 159 example, disorientation 96 example, self care ability obstacle 237 example, personality disorder 56 are routine, night noisy 34 is routine, cardiopalmus dreaminess 51 example.The basic document of the seven groups of old dementia patients be divided into, as the significantly difference (P > 0.05) such as age, sex, has comparability.
1.2 method
The patient 350 examples of random selecting being suffered to senile dementia is handled as follows, these patients are divided into seven groups, often organize 50 people, take the Chinese medicine preparation of embodiment of the present invention 1-4 senile dementia prevention and cure respectively, patent application 201510062471.X embodiment 1 Chinese medicine preparation, patent application 01121542.9 embodiment Chinese medicine preparation, patent application 201310022390.8 embodiment Chinese medicine preparation treat, above-mentioned seven groups are sorted as A-G group successively, add up the living condition of seven groups of patients after Drug therapy, the curative effect of these seven groups of medicines is analyzed.
1.3 statistical method
Adopt SPSS13.0 statistical software to analyze, statistics adopts t to check and X2 inspection, when P < 0.05 represents to there is significant difference, has statistical significance.
1.4 treatment standards
Effective: clinical symptom disappearance, basic living ability recovers normal, and insomniac's drug withdrawal can normally be fallen asleep after 1 year, and memory recovers normal, and severe patient disease has no and increases the weight of and be improved.
Effective: clinical symptom relief, stable disease, observes more than 1 month, and nothing repeatedly.
Invalid: clinical symptoms is not improved.
2 results
Tested by Drug therapy, we find, seven groups of patients are after carrying out Drug therapy, without death in seven groups of patients, the Chinese medicine composition curative effect of senile dementia prevention and cure of the present invention is the most remarkable, have the case scenario of 96% to be clearly better, and the Chinese medicine composition of senile dementia prevention and cure of the present invention have no adverse reaction; It is comparatively remarkable that patent application 201510062471.X, 01121542.9,01310022390.8 prevents and treats senile dementia therapeutic effect, has the case of 88%, 86%, 80% to take a turn for the better respectively, but the generation that has no adverse reaction.The clinical effectiveness of seven groups of Drug therapys compares in table 1.
The clinical effectiveness of table 1 four groups of Drug therapys compares
| Group | Number of cases | Significantly | Effectively | Invalid | Total effective rate |
| A group | 50 | 21 | 26 | 3 | 94％ |
| B group | 50 | 23 | 25 | 2 | 96％ |
| C group | 50 | 20 | 26 | 4 | 92％ |
| D group | 50 | 21 | 25 | 4 | 92％ |
| E group | 50 | 19 | 25 | 6 | 88％ |
| F group | 50 | 20 | 23 | 7 | 86％ |
| G group | 50 | 17 | 23 | 10 | 80％ |
Note: P < 0.05
Experimental example 2: the present invention prevents and treats the Chinese medicine composition clinical research situation two of senile dementia
1 case selection
This group totally 100 example, wherein man 58 example, female 42 example, age 57-90 year between, course of disease 3-15, all meets AD diagnostic criteria.
2 application processes
Giving the Chinese medicine preparation of the control senile dementia of the present embodiment 1, every day 2 doses, take 3 courses for the treatment of, 2 months is a course for the treatment of.
3 curative effects are as follows
Insight recovers 55 examples, anxiety state alleviation person 32 example, be slow in action and improve 40, hallucination vain hope minimizing 47 example, the thought disturbance person of making moderate progress 72 example, the apathy person of making moderate progress 76 example, behavior disorder improver 82 example, sensitive person 67 example of readme brain response, depressed mood turns day by day optimistic person 61 example, lack energy person and improve 87 examples, without obvious changer 2 example.
Experimental example 3: model case
Zhang, female, 78 years old, decrease of cognitive function, early stage based on nearly Impairment of Memory, Impairment of Memory is relatively light, and showing as the thing, the just what someone said that just occur can not remember, forget familiar name, people removes relatively to thing of the remote past memory, simultaneously degradation symptom under language function.After taking 1 course for the treatment of of control senile dementia Chinese medicine preparation of the present embodiment 5, symptom is obviously improved, and after 3 courses for the treatment of, above symptom disappears substantially, and sleep quality is good, and memory obviously strengthens.
Grandson, man, 80 years old, depressed, anxious, easily flare up, with hallucination and vain hope, and often have a sleepless night, take the Chinese medicine preparation of the control senile dementia of the present embodiment 6, after the course for the treatment of, symptom makes moderate progress, and after 4 courses for the treatment of, above symptom disappears substantially, be emotionally stable, mood is optimistic, and memory is recovered, and can participate in collective activity, behavior initiative strengthens, and thinking is clear.
Zhao, man, 75 years old, initial activity of daily living declined gradually, had shown as daily life and more and more difficult, and having a meal afterwards wears the clothes goes to toilet and also want help, and daily life needs other people to look after, last to not taking care of oneself completely.Take the Chinese medicine preparation of the control senile dementia of the present embodiment 7, after 3 courses for the treatment of, daily life can take care of oneself gradually, and thinking is clear gradually, and memory strengthens gradually.
High certain, female, 63 years old, psychasthenia, bulesis went down, poor memory, murmurs to oneself, and behavior is unsociable and eccentric, realizes without audition.Take the Chinese medicine preparation of the control senile dementia of the present embodiment 8, after 2 courses for the treatment of, each symptom is clearly better, and the symptom such as after continuing to take two weeks, to murmur to oneself, behavior is unsociable and eccentric is obviously improved, hypermnesia and thinking of logic is rationally clear.
Experimental example 4: the safety testing of product of the present invention
Get the sample that embodiment of the present invention 1-8 is obtained, according to people's consumption 20 times, the consumption of 50 times, toxicological experiment research is carried out with mice, results of animal shows, during people's consumption 20 times Mouse Weight without significant change, be a cup too low depressed, movable to reduce or other symptom occurs, and has slight lethargy phenomenon during people's consumption 50 times.Prove that product toxic and side effects of the present invention is little, be very beneficial for Clinical practice.
Experimental example 5: the stability test of product of the present invention
Get the sample that embodiment of the present invention 1-8 is obtained, temperature 40 DEG C ± 2 DEG C, under the condition of relative humidity 75% ± 5%, carry out accelerated stability test, once investigate in duration of test 1st month, 2 months, 3 months, 6 samplings at the end of month respectively; With character, moisture, effective active component content and health examination for index, check the stability of product.Result shows: product prepared by the present invention is stored under accelerated test condition, each investigation project is showed no exception, and moisture change controls within 5%, and active constituent content significant change does not occur yet, its health examination all meets expection regulation, shows that product quality of the present invention meets the requirements.
From above data, the product that the present invention utilizes the compositions such as Radix Ginseng, Sichuan Herba Dendrobii, Carapax et Plastrum Testudinis to make, effectively can prevent and treat senile dementia disease, through investigations such as curative effect, safety, product qualities, corresponding index all surpasss the expectation requirement, illustrate that recipe design of the present invention is reasonable, preparation method is simply controlled, has a good application prospect.
Claims (10)
1. a Chinese medicine composition, described compositions is made up of the Chinese medicinal components of following weight portion:
Radix Ginseng 27 ~ 30 parts, Ganoderma 30 ~ 36 parts, the Radix Astragali 30 ~ 36 parts, Radix Ophiopogonis 15 ~ 36 parts, Sichuan Herba Dendrobii 20 ~ 36 parts, Radix Polygalae 15 ~ 27 parts, Rhizoma Acori Graminei 20 ~ 27 parts, Pumex 25 ~ 45 parts, 30 ~ 35 parts, Rhizoma Gastrodiae, Radix Angelicae Sinensis 30 ~ 36 parts, Hirudo 9 ~ 12 parts, Rhizoma Chuanxiong 20 ~ 27 parts, Os Draconis 90 ~ 96 parts, Carapax et Plastrum Testudinis 60 ~ 72 parts, Semen Ziziphi Spinosae (parched) 45 ~ 50 parts, Rhizoma Polygonati 45 ~ 50 parts, Fructus Lycii 30 ~ 36 parts, Herba Epimedii 40 ~ 45 parts, Radix Aconiti Lateralis Preparata 15 ~ 20 parts, Placenta Hominis 20 ~ 30 parts.
2. Chinese medicine composition according to claim 1, it is characterized in that, described compositions is made up of the Chinese medicinal components of following weight portion: Radix Ginseng 29 parts, Ganoderma 33 parts, the Radix Astragali 33 parts, Radix Ophiopogonis 30 parts, Sichuan Herba Dendrobii 28 parts, Radix Polygalae 20 parts, Rhizoma Acori Graminei 24 parts, Pumex 30 parts, 32 parts, Rhizoma Gastrodiae, Radix Angelicae Sinensis 34 parts, Hirudo 10 parts, Rhizoma Chuanxiong 25 parts, Os Draconis 92 parts, Carapax et Plastrum Testudinis 65 parts, Semen Ziziphi Spinosae (parched) 48 parts, Rhizoma Polygonati 47 parts, Fructus Lycii 32 parts, Herba Epimedii 42 parts, Radix Aconiti Lateralis Preparata 18 parts, Placenta Hominis 22 parts.
3. prevent and treat a pharmaceutical preparation for senile dementia, be made up of the Chinese medicine composition described in claim 1 or 2 and the acceptable adjuvant of pharmacy.
4. pharmaceutical preparation as claimed in claim 3, it is characterized in that, described pharmaceutical preparation is peroral dosage form, and this peroral dosage form comprises granule, tablet, capsule or sweet unguentum.
5. pharmaceutical preparation as claimed in claim 4, it is characterized in that, the preparation method of described granule comprises the following steps:
1) Traditional Chinese medicine composition formula amount component is taken respectively;
2) Radix Ginseng, Ganoderma, Pumex, Rhizoma Gastrodiae, Rhizoma Chuanxiong, Os Draconis, Carapax et Plastrum Testudinis, Rhizoma Polygonati are ground into granule, Placenta Hominis cut into slices, with residue ten simply medical material decoct with water three times, first time 2 ~ 2.5h, second time 1.5 ~ 2h, third time 1 ~ 1.5h, merges three filtrates;
3) gained filtrate concentrated, when obtaining 80 DEG C, relative density is the clear paste of 1.25 ~ 1.30;
4) add mannitol or dextrin, make granule, mixing, granulate, dry, granulate, to obtain final product.
6. pharmaceutical preparation as claimed in claim 4, it is characterized in that, the preparation method of described tablet, is get in process for producing granula through 1) ~ 3) the obtained clear paste of step, add sorbitol, carboxymethyl starch sodium, mixing, granulates, dry, add magnesium stearate again, mixing, tabletting, to obtain final product.
7. pharmaceutical preparation as claimed in claim 4, it is characterized in that, the preparation method of described capsule, is get in process for producing granula through 1) ~ 3) the obtained clear paste of step, add pregelatinized Starch, dry, pulverize, sieve, add micropowder silica gel or magnesium stearate, mixing, incapsulates, to obtain final product.
8. pharmaceutical preparation as claimed in claim 4, it is characterized in that, the preparation method of described sweet unguentum, get in process for producing granula through 1), 2) the obtained filtrate of step, gained filtrate concentrated, when obtaining 80 DEG C, relative density is the clear paste of 1.18 ~ 1.22, filter, add refined honey, simmer down to thick paste, to obtain final product.
9. preparation method according to claim 8, is characterized in that, described thick paste relative density at 80 DEG C is 1.30 ~ 1.35.
10. the application of the Chinese medicine composition described in claim 1 or 2 in control senile dementia.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108743810A (en) * | 2018-07-13 | 2018-11-06 | 芜湖耄智生物科技有限公司 | Chinese medicine composition and preparation method thereof for preventing senile dementia |
| CN108815371A (en) * | 2018-07-13 | 2018-11-16 | 芜湖耄智生物科技有限公司 | Chinese medicine composition and preparation method thereof for treating Alzheimer disease |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103071048A (en) * | 2013-02-07 | 2013-05-01 | 贵州神奇投资有限公司 | Traditional Chinese medicine composition for treating alzheimer diseases and preparation method of traditional Chinese medicine composition |
| CN103316234A (en) * | 2013-05-23 | 2013-09-25 | 重庆安碧捷科技股份有限公司 | Health product for preventing and improving Alzheimer's disease and applications thereof |
| CN104645029A (en) * | 2015-01-31 | 2015-05-27 | 吉林大学 | Drug for treating senile dementia |
-
2015
- 2015-12-09 CN CN201510906830.5A patent/CN105521306A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103071048A (en) * | 2013-02-07 | 2013-05-01 | 贵州神奇投资有限公司 | Traditional Chinese medicine composition for treating alzheimer diseases and preparation method of traditional Chinese medicine composition |
| CN103316234A (en) * | 2013-05-23 | 2013-09-25 | 重庆安碧捷科技股份有限公司 | Health product for preventing and improving Alzheimer's disease and applications thereof |
| CN104645029A (en) * | 2015-01-31 | 2015-05-27 | 吉林大学 | Drug for treating senile dementia |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108743810A (en) * | 2018-07-13 | 2018-11-06 | 芜湖耄智生物科技有限公司 | Chinese medicine composition and preparation method thereof for preventing senile dementia |
| CN108815371A (en) * | 2018-07-13 | 2018-11-16 | 芜湖耄智生物科技有限公司 | Chinese medicine composition and preparation method thereof for treating Alzheimer disease |
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