CN105477302A - Insomnia treating traditional Chinese medicine composition and preparation method thereof - Google Patents
Insomnia treating traditional Chinese medicine composition and preparation method thereof Download PDFInfo
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- CN105477302A CN105477302A CN201510965909.5A CN201510965909A CN105477302A CN 105477302 A CN105477302 A CN 105477302A CN 201510965909 A CN201510965909 A CN 201510965909A CN 105477302 A CN105477302 A CN 105477302A
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Abstract
The invention belongs to the field of traditional Chinese medicine and relates to an insomnia treating traditional Chinese medicine composition and a preparation method thereof. The traditional Chinese medicine composition is prepared from, by weight, 10-20 parts of Vitex negundo, 10-20 parts of semen myristicae, 10-22 parts of Polygala tenuifolia, 12-18 parts of Ussilago farfara, 10-18 parts of Poria with hostwood, 8-16 parts of radix acanthopanacis senticosi, 6-12 parts of Arillus longan, 8-14 parts of Lilium brownii, 6-12 parts of semen nelumbinis, 6-14 parts of Flos chrysanthemi indici, 6-12 parts of Ziziphus jujube, 6-12 parts of Flos rosae rugosae and 2-10 parts of radix glycyrrhizae. The traditional Chinese medicine composition has efficacy of calming the nerves, promoting intelligence, nourishing blood, clearing heat, detoxicating, promoting qi circulation and relieving depression and the like, has effect in treating both symptoms and root causes of insomnia, and has no side and toxic effect.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to Chinese medicine composition of a kind for the treatment of of insomnia patients and preparation method thereof.
Background technology
Insomnia, refers to and often can not obtain ortho sleep.Be also called " being insomnia " " insomnia " " unable to close the eyes " in doctor's nationality in ancient times " must not crouch ".Modern study is thought, insomnia refers to that the length of one's sleep not enough, or sleeps not dark, not yet done, and initial insomnia, interruption insomnia, terminal can be divided into have a sleepless night three kinds.Initial insomnia refers to difficulty falling asleep, arrive and could fall asleep after midnight, how because psychentonia, anxiety, fear etc. cause.Be interrupted insomnia, refer to and sleep unquiet, easily wake up with a start, often have nightmare, middle age dyspepsia, easily this thing happens.Terminal is had a sleepless night, and is to fall asleep not difficult, but the persistent period is not long, namely can not fall asleep afterwards after midnight again, senile hypertension, arteriosclerosis, and dysthymia patient, often has this kind of insomnia.
Though the cause of disease of insomnia is many, but it is in the majority with internal injury causes of disease such as feelings will, diet or deficiency of qi and blood, by these causes of disease cause the heart, liver, gallbladder, spleen, stomach, kidney qi-blood disharmony, imbalance of YIN and YANG, its basic pathogenesis is based on deficiency of heart-blood, milk-livered, insufficiency of the spleen, deficiency of kidney-YIN and then cause the heart to become homeless foster and partially high by heart-fire, stagnation of liver-QI, expectorant heat, stomach-QI being unable to descend normally and then cause irritability two aspect.Its sick position is at the heart, but in close relations with liver, gallbladder, spleen, stomach, kidney.Insomnia deficiency syndrome are many by deficiency of both the heart and spleen, and timidness due to deficiency of the heart, hyperactivity of fire caused by deficiency of YIN, causes caused by lack of preservation of spirit.Insomnia excess syndrome is then how flourishing by heart-fire, and pathogenic fire derived from stagnation of liver-QI, disturbs in expectorant heat, cause caused by irritability.But insomnia prolonged illness can show as the double folder of deficiency and excess, or caused by blood stasis, therefore Qing Dynasty's Wang Qingren decoction for removing blood stasis is treated.The principle of Chinese medicine Cure for insomnia is: at reinforce insufficiency and reduce excessiveness, and the basis of adjustment internal organs negative and positive of qi and blood is aided with the base therapy method that tranquilizing the mind is primary disease.The suitable reducing for the excess syndrome of excess syndrome, as dispersing the stagnated live-QI to relieve the stagnation of QI, pathogenic fire reducing clearing away phlegm, promoting digestion and regulating the middle JIAO.The suitable tonifying for deficiency syndrome of deficiency syndrome, as benefiting QI and nourishing blood, spleen invigorating, tonifying liver, kidney tonifying.With the passing of time, QI and blood consumption wound, also can transfer deficiency syndrome to, simulataneous insufficiency and excessive person to excess syndrome, and controlling should reinforcement and elimination in combination.The use of tranquilizing the mind method in conjunction with clinical, will be selected the concrete method for the treatment of such as nourishing blood to tranquillize the mind, tranquillizing the mind by relieving convulsion, clearing away heart-fire for tranquillization, and notes coordinating spiritual healing respectively, to eliminate nervous anxiety, keeps spirit happy.
At present, clinical treatment insomnia adopts the calm class medicine of Western medicine, can take effect rapidly at the initial stage of taking medicine, but these medicines also exist that side effect is large, Time of Administration long, the shortcoming of easily recurrence after drug withdrawal.Often take sleeping pill and not only can bring drug resistance, dependency, also can bring and be still drank after a night, withdrawal symptom, numerous adverse consequences such as memory impairment.Chinese traditional treatment mainly adopts the methods such as acupuncture, but the course for the treatment of is longer, takes effect not obvious.
Chinese patent application CN201410281941 discloses a kind of Chinese medicine of Cure for insomnia, certain weight ratio is pressed formulated by Yunnan-Tibet square bar cypress, Corallium Japonicum Kishinouye, Fructus Lycii, large thick branch moss, Semen Ziziphi Spinosae, Fructus Gardeniae, the Cortex Eucommiae, Cornu Saigae Tataricae, Semen Platycladi, the Rhizoma Atractylodis Macrocephalae, Folium Mori, Cortex Moutan, Bombyx Batryticatus, Fluoritum, Fructus Arctii and Spica Prunellae, this Drug therapy insomnia instant effect, effective percentage is high, but containing rare medical materials such as Yunnan-Tibet square bar cypress, Corallium Japonicum Kishinouye, Cornu Saigae Tataricae in medicament, adopt destructible ecological environment.
Summary of the invention
For solving the deficiencies in the prior art, the object of this invention is to provide Chinese medicine composition of a kind for the treatment of of insomnia patients and preparation method thereof.
The Chinese medicine composition for the treatment of of insomnia patients of the present invention is made up of the raw material of following weight portion:
Herba Viticis Cannabifoliae 10-20 part, Semen Myristicae 10-20 part, Radix Polygalae 10-22 part, Flos Farfarae 12-18 part, Poria cum Radix Pini 10-18 part, Radix Et Caulis Acanthopanacis Senticosi 8-16 part, Arillus Longan 6-12 part, Bulbus Lilii 8-14 part, Semen Nelumbinis 6-12 part, Flos Chrysanthemi Indici 6-14 part, Fructus Jujubae 6-12 part, Flos Rosae Rugosae 6-12 part and Radix Glycyrrhizae 2-10 part.
In the scope of above-mentioned weight portion, the comparatively significant formula of preferred 3 curative effects, are respectively:
Formula 1: Herba Viticis Cannabifoliae 10 parts, Semen Myristicae 10 parts, Radix Polygalae 10 parts, Flos Farfarae 12 parts, Poria cum Radix Pini 10 parts, Radix Et Caulis Acanthopanacis Senticosi 8 parts, Arillus Longan 6 parts, Bulbus Lilii 8 parts, 6 parts, Semen Nelumbinis, Flos Chrysanthemi Indici 6 parts, Fructus Jujubae 6 parts, Flos Rosae Rugosae 6 parts and 2 parts, Radix Glycyrrhizae.
Formula 2: Herba Viticis Cannabifoliae 20 parts, Semen Myristicae 20 parts, Radix Polygalae 22 parts, Flos Farfarae 18 parts, Poria cum Radix Pini 18 parts, Radix Et Caulis Acanthopanacis Senticosi 16 parts, Arillus Longan 12 parts, Bulbus Lilii 14 parts, 12 parts, Semen Nelumbinis, Flos Chrysanthemi Indici 14 parts, Fructus Jujubae 12 parts, Flos Rosae Rugosae 12 parts and 10 parts, Radix Glycyrrhizae.
Formula 3: Herba Viticis Cannabifoliae 15 parts, Semen Myristicae 15 parts, Radix Polygalae 16 parts, Flos Farfarae 15 parts, Poria cum Radix Pini 14 parts, Radix Et Caulis Acanthopanacis Senticosi 12 parts, Arillus Longan 10 parts, Bulbus Lilii 10 parts, 8 parts, Semen Nelumbinis, Flos Chrysanthemi Indici 10 parts, Fructus Jujubae 8 parts, Flos Rosae Rugosae 8 parts and 6 parts, Radix Glycyrrhizae.
Source, the nature and flavor of Chinese medicine composition of the present invention Chinese crude drug used, return through and effect:
Semen Myristicae: this product is the myristic dry kernel of Myristicaceae Nutmeg plant; Acrid in the mouth, warm in nature; Return spleen, stomach, large intestine channel; Warming middle-JIAO to promote flow of QI, relieving diarrhea with astringents.
Radix Polygalae: this product is milk wort Radix Polygalae or ovum leaf dry root far away; Bitter in the mouth, pungent, warm in nature; GUIXIN, kidney, lung meridian; To calm the nerves Fructus Alpiniae Oxyphyllae, eliminate the phlegm, detumescence.Flos Farfarae: this product is the dried floral of feverfew coltsfoot; Acrid in the mouth, micro-hardship, warm in nature; Return lung meridian; Nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm.
Poria cum Radix Pini: this product is entertain the part of Radix Pini massonianae or fine core person in the middle of poria cocos sclerotium; Acrid in the mouth, hardship, property is put down; GUIXIN, kidney channel; Mind calming, calms the nerves, diuretic.
Radix Et Caulis Acanthopanacis Senticosi: this product is the drying of Araliaceae Radix Et Caulis Acanthopanacis Senticosi, root and rhizome or stem; Acrid in the mouth, micro-hardship, warm in nature; Return spleen, kidney, heart channel; Replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization.
Arillus Longan: this product is the aril of Sapindaceae Euphoria plant Arillus Longan; Sweet in the mouth, warm in nature; GUIXIN, spleen channel; Invigorating the heart and spleen, nourishing blood to tranquillize the mind.
Bulbus Lilii: this product is the dry meat scale leaf of liliaceous plant tiger lily, Bulbus Lilii or Lilium tenuifolium; Sweet in the mouth, cold in nature; GUIXIN, lung meridian; Nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.
Radix Polygalae: this product is milk wort Radix Polygalae or ovum leaf dry root far away; Bitter in the mouth, pungent, warm in nature; GUIXIN, kidney, lung meridian; To calm the nerves Fructus Alpiniae Oxyphyllae, eliminate the phlegm, detumescence.
Semen Nelumbinis: this product is the dry mature seed of nymphaeaceae plant lotus; Sweet in the mouth, puckery, property is put down; Return spleen, kidney, heart channel; Spleen reinforcing antidiarrheal, kidney tonifying arresting seminal emission, tranquilizing by nourishing the heart.
Flos Chrysanthemi Indici: this product is the dry capitulum of feverfew Herba Dendranthematis indici; Bitter in the mouth, pungent, cold nature; Return liver, heart channel; Heat-clearing and toxic substances removing.
Herba Verbenae: this product is the dry aerial parts of Verbenaceae Herba Verbenae; Bitter in the mouth, cool in nature; Return liver, spleen channel; Promoting blood circulation to remove blood stasis, preventing the attack (or recurrence) of malaria, removing toxic substances, inducing diuresis to remove edema.
Fructus Jujubae: this product is the dry mature fruit of Rhamnaceae jujube Fructus Jujubae; Sweet in the mouth, warm in nature; Return spleen, stomach warp; Invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.
Flos Rosae Rugosae: this product is the dry flower of rosaceous plant Flos Rosae Rugosae; Sweet in the mouth, micro-hardship, warm in nature; Return liver, spleen channel; Promoting QI circulation for relieving depression, and blood, pain relieving.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L.; Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The prescription analysis of Chinese medicine of the present invention:
Chinese prescription of the present invention with Semen Myristicae, Radix Polygalae and Radix Et Caulis Acanthopanacis Senticosi for monarch drug, warming middle-JIAO to promote flow of QI, Fructus Alpiniae Oxyphyllae of calming the nerves, tonifying the kidney for tranquilization; With Flos Farfarae, Poria cum Radix Pini, Arillus Longan, Bulbus Lilii and Semen Nelumbinis for ministerial drug, nourishing the lung to keep the adverse QI downward, nourishing blood to tranquillize the mind, tranquilizing by nourishing the heart; With Flos Chrysanthemi Indici, Herba Verbenae, Fructus Jujubae and Flos Rosae Rugosae for adjuvant drug, heat-clearing and toxic substances removing, inducing diuresis to remove edema, nourishing blood to tranquillize the mind, promoting QI circulation for relieving depression; With Radix Glycyrrhizae for making medicine, mind tranquilizing and the heart calming, coordinating the actions of various ingredients in a prescription; The all medicines of monarch coordinate, and collaborative promotion, complements each other, finally reach Fructus Alpiniae Oxyphyllae of calming the nerves, nourishing blood to tranquillize the mind, heat-clearing and toxic substances removing, the effects such as promoting QI circulation for relieving depression, treatment of insomnia patients is had to the effect for the treatment of both the principal and secondary aspects of a disease, have no side effect.
The present invention also provides the preparation method of described Chinese medicine composition, comprises following steps:
Step 1: take Herba Viticis Cannabifoliae, Semen Myristicae, Radix Polygalae, Poria cum Radix Pini and Radix Et Caulis Acanthopanacis Senticosi respectively in proportion, clean, crushed after being dried, merge coarse powder, adding coarse powder gross weight 8-10 times amount volume fraction is the ethanol of 60-80%, microwave extraction 8-15 minute, microwave power is 400-600W, and Extracting temperature is 40-60 DEG C, filters and retains filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained extract A;
Step 2: take Flos Farfarae, Arillus Longan, Bulbus Lilii, Semen Nelumbinis, Flos Chrysanthemi Indici, Fructus Jujubae, Flos Rosae Rugosae and Radix Glycyrrhizae respectively in proportion, pulverize after cleaning, drying, merge coarse powder, and merge with the filtering residue of step 1, add the water of medical material gross weight 8-12 times amount, reflux, extract, 2-3 time, each 3-6 hour, filter, merging filtrate, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained extract B;
Step 3: united extraction thing A and extract B, drying under reduced pressure, pulverizes, and crosses 80-100 mesh sieve, to obtain final product.
Compared with prior art, Chinese medicine composition of the present invention has following advantage:
1. Chinese medicine composition of the present invention is made up of natural Chinese medicines material, all medicines work in coordination with, significantly reduce untoward reaction and toxic and side effects, have good effect, treating both the principal and secondary aspects of a disease, stress nurse one's health treatment advantage;
2. pharmacodynamic experiment shows, Chinese medicine composition of the present invention significantly can reduce mice freely movable number of times and convulsions incidence rate, significantly can improve the symptom of insomnia; Clinical data shows, Chinese medicine composition of the present invention determined curative effect in Cure for insomnia, has no adverse reaction, and has liver heat removing to relieve dizziness, high fever, infantile convulsions, epilepsy, etc., the effect such as QI invigorating is relieving convulsion, nourishing blood to tranquillize the mind, depressed liver-energy dispersing and QI regulating.
3. simple and easy to do, the efficacy stability of Chinese medicine composition preparation technology of the present invention, be easy to apply.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, be all included within the scope of the present invention.
EXAMPLE l
The embodiment of the present invention 1 Chinese medicine composition is made up of the raw material of following weight portion:
Herba Viticis Cannabifoliae 10 parts, Semen Myristicae 10 parts, Radix Polygalae 10 parts, Flos Farfarae 12 parts, Poria cum Radix Pini 10 parts, Radix Et Caulis Acanthopanacis Senticosi 8 parts, Arillus Longan 6 parts, Bulbus Lilii 8 parts, 6 parts, Semen Nelumbinis, Flos Chrysanthemi Indici 6 parts, Fructus Jujubae 6 parts, Flos Rosae Rugosae 6 parts and 2 parts, Radix Glycyrrhizae.
Preparation method:
Step 1: take Herba Viticis Cannabifoliae, Semen Myristicae, Radix Polygalae, Poria cum Radix Pini and Radix Et Caulis Acanthopanacis Senticosi respectively in proportion, clean, crushed after being dried, merge coarse powder, adding coarse powder gross weight 8 times amount volume fraction is the ethanol of 75%, microwave extraction 10 minutes, microwave power is 500W, and Extracting temperature is 50 DEG C, filters and retains filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10, obtained extract A;
Step 2: take Flos Farfarae, Arillus Longan, Bulbus Lilii, Semen Nelumbinis, Flos Chrysanthemi Indici, Fructus Jujubae, Flos Rosae Rugosae and Radix Glycyrrhizae respectively in proportion, pulverize after cleaning, drying, merge coarse powder, and merge with the filtering residue of step 1, add the water of medical material gross weight 8 times amount, reflux, extract, 3 times, each 4 hours, filter, merging filtrate, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10, obtained extract B;
Step 3: united extraction thing A and extract B, drying under reduced pressure, pulverizes, and crosses 80 mesh sieves, obtains traditional Chinese medicine fine powder.
Step 4: add suitable adjuvant toward traditional Chinese medicine fine powder, utilizes modern general preparation technique to make capsule.
Embodiment 2
The embodiment of the present invention 2 Chinese medicine composition is made up of the raw material of following weight portion:
Herba Viticis Cannabifoliae 20 parts, Semen Myristicae 20 parts, Radix Polygalae 22 parts, Flos Farfarae 18 parts, Poria cum Radix Pini 18 parts, Radix Et Caulis Acanthopanacis Senticosi 16 parts, Arillus Longan 12 parts, Bulbus Lilii 14 parts, 12 parts, Semen Nelumbinis, Flos Chrysanthemi Indici 14 parts, Fructus Jujubae 12 parts, Flos Rosae Rugosae 12 parts and 10 parts, Radix Glycyrrhizae.
Preparation method: with embodiment 1.
Embodiment 3
The embodiment of the present invention 3 Chinese medicine composition is made up of the raw material of following weight portion:
Herba Viticis Cannabifoliae 15 parts, Semen Myristicae 15 parts, Radix Polygalae 16 parts, Flos Farfarae 15 parts, Poria cum Radix Pini 14 parts, Radix Et Caulis Acanthopanacis Senticosi 12 parts, Arillus Longan 10 parts, Bulbus Lilii 10 parts, 8 parts, Semen Nelumbinis, Flos Chrysanthemi Indici 10 parts, Fructus Jujubae 8 parts, Flos Rosae Rugosae 8 parts and 6 parts, Radix Glycyrrhizae.
Preparation method: with embodiment 1.
Pharmacodynamics test
Experimental example 1, pharmaceutical preparation of the present invention are tested the impact of spontaneous activity in mice
1, laboratory animal: get SPF level ICR mice 96, body weight 22-26g, male and female half and half, be divided into 8 groups at random, often organizes 12.
2, Experimental agents and dosage regimen:
A group: Experimental agents is the capsule that the embodiment of the present invention 1 obtains, and is divided into basic, normal, high 3 dosage groups.The using dosage of basic, normal, high dosage group is respectively 2g/kg, 4g/kg, 8g/kg, every day gavage 1 time.
B group: Experimental agents is that in the present invention, embodiment 2 obtains capsule, animal grouping and dosage regimen are with A group.
Normal group: get 1 group of rat, gavage equal-volume normal saline.
Positive controls: Experimental agents is hundred happy dormancy capsules (Yangzijiang Pharmaceutical Group Co., Ltd), and dosage is 8g/kg, every day gavage 1 time.
3, experimental technique: the continuous gavage 7d of mice, in last administration 8h fasting, front 1h prohibits water, to give after mouse stomach 30 minutes, is placed in by mice in autonomic activities instrument, surveys the autonomic activities number of times of mice, and requirement of experiment detects in the environment of quiet, dark.Mice conforms 5min, the movable number of times of mice in counting 10min.
4, experimental result: as shown in table 1.
The comparison of the movable number of times of mice respectively organized by table 1
Note: compare with Normal group,
*p < 0.05,
*p < 0.01,
* *p < 0.001; Compare with positive controls,
#p < 0.05,
##p < 0.01,
###p < 0.001.
From upper table 1, pharmaceutical preparation of the present invention significantly reduces the autonomic activities number of times (P < 0.05) of mice, and dosage is good dose-effect relationship, wherein with A group and the obtained capsule effect of embodiment 1 better.In addition, the middle and high dosage group of pharmaceutical preparation of the present invention compares with positive controls, all has significant difference (P < 0.05), more excellent to the inhibition of mice autonomic activities.
Experimental example 2, Chinese medicine composition of the present invention are tested the impact of mice convulsion degree
1, laboratory animal: get SPF level ICR mice 60, body weight 22-28g, male and female half and half, be divided into 5 groups at random, often organizes 12.
2, Experimental agents and dosage regimen:
Administration group: Experimental agents is the capsule that the embodiment of the present invention 1 obtains, and is divided into basic, normal, high 3 dosage groups.The using dosage of basic, normal, high dosage group is respectively 2g/kg, 4g/kg, 8g/kg, every day gavage 1 time.
Normal group: get 1 group of rat, gavage equal-volume normal saline.
Positive controls: Experimental agents is hundred happy dormancy capsules (Yangzijiang Pharmaceutical Group Co., Ltd), and dosage is 8g/kg, every day gavage 1 time.
3, experimental technique: mice successive administration 7 days, in the 3-mercaptopropionic acid (3-MP) of last administration 30min pneumoretroperitoneum injection 20ul/kg dosage, observes the generation with or without convulsions phenomenon, calculates the incidence rate that it is fainted from fear.
4, experimental result: in table 2.
Table 2 mice convulsion experimental result
From upper table 2, take the convulsions generation number that Chinese medicinal composition capsules of the present invention and hundred happy dormancy capsules all can reduce mice, illustrate that Chinese medicine composition of the present invention has certain sedation.
The clinical experiment of experimental example 3, Chinese medicine composition of the present invention
(1) study subject is selected
Tcm diagnosis standard:
Diagnostic criteria formulates following standard with reference to the selected reference " insomnia definition, diagnosis and Drug therapy Consensus of experts (draft) " of clinical data case and " Chinese Spirit Obstacles classification and diagnostic criteria (CCMDD ":
1. the long time for falling asleep of Sleep latency is more than 30min;
2. sleep maintains obstacle number of times of awakening night and is greater than 2 times;
3. shallow, the dreaminess of sleep quality decline sleep;
4. total sleep time shortening is less than 5 hours
5. residual effect large sensation giddy in morning in the daytime, lassitude, drowsiness, weak etc.
Exclusion standard: 1. the age is under-18s, over-65s person; 2. severe physical illness and principal characteristic mental sickness person; 3. also with other drug and antipsychotic drug person; 4. serious suicidal attempt and actor is had; 5. gestation and women breast-feeding their children; 6. therapist is mismatched.
(2) clinical experiment scheme
1, physical data
By diagnostic criteria, the insomnia clinical volunteers patients that screening 480 example is medical, men and women half and half, age 28-60 year, 35 years old mean age, the course of disease 6 months-5 years.It is divided at random treatment A, B, C group and matched group four groups, often organizes each 120 examples.Four groups influence factors such as sex, age, the course of disease, the state of an illness, through statistical procedures, aspect, without significant difference, has comparability.
2, Experimental agents and experimental technique
Treatment A, B, C group: take capsule prepared by the embodiment of the present invention 1,2,3 respectively, amount to crude drug content 0.35g/ grain, every day 3 times, each 1; Within 7 days, be a course for the treatment of, after taking for 3 courses for the treatment of continuously, evaluate curative effect.
Matched group: take hundred happy dormancy capsules (Yangzijiang Pharmaceutical Group Co., Ltd).Take according to suggestion taking dose (20mg/kg), 3 times on the one, within 7 days, be a course for the treatment of, after 3 courses for the treatment of, evaluate curative effect.
3, curative effect determinate standard
Diagnostic criteria is by the standard envisages of " guideline of clinical investigations of new Chinese medicine Cure for insomnia " in " new Chinese medicine guideline of clinical investigations ".
Recovery from illness: fall asleep smoothly, recover the length of one's sleep normal, or the length of one's sleep is at more than 6h, sleeps deep, its clinical symptoms disappears substantially.
Effective: sleep is clearly better, and the length of one's sleep increases more than 3h, Depth of sleep increases, and clinical symptoms makes moderate progress.
Effective: symptom alleviates, the length of one's sleep, comparatively front increase was less than 3h.
Invalid: after treatment, insomnia is not improved or instead adds severe one, and clinical symptoms is also not improved.
4, therapeutic outcome
Table 3 therapeutic effect
Clinical laboratory data shows, and traditional Chinese medicine composition for treating of the present invention insomnia effect recovery from illness efficiency is up to more than 50.0%, and total effective rate reaches more than 90.0%, higher than the total effective rate of contrast medicine 85.0%, wherein optimum with the effect for the treatment of A group and embodiment 1.Clinical trial results proves traditional Chinese medicine composition for treating of the present invention insomnia Be very effective, can be used as medicament for treating insomnia, has higher clinical generalization value.
Claims (7)
1. a Chinese medicine composition for treatment of insomnia patients, is characterized in that, described Chinese medicine composition is made up of the raw material of following weight portion:
Herba Viticis Cannabifoliae 10-20 part, Semen Myristicae 10-20 part, Radix Polygalae 10-22 part, Flos Farfarae 12-18 part, Poria cum Radix Pini 10-18 part, Radix Et Caulis Acanthopanacis Senticosi 8-16 part, Arillus Longan 6-12 part, Bulbus Lilii 8-14 part, Semen Nelumbinis 6-12 part, Flos Chrysanthemi Indici 6-14 part, Fructus Jujubae 6-12 part, Flos Rosae Rugosae 6-12 part and Radix Glycyrrhizae 2-10 part.
2. the Chinese medicine composition for the treatment of of insomnia patients as claimed in claim 1, it is characterized in that, described Chinese medicine composition is made up of the raw material of following weight portion:
Herba Viticis Cannabifoliae 10 parts, Semen Myristicae 10 parts, Radix Polygalae 10 parts, Flos Farfarae 12 parts, Poria cum Radix Pini 10 parts, Radix Et Caulis Acanthopanacis Senticosi 8 parts, Arillus Longan 6 parts, Bulbus Lilii 8 parts, 6 parts, Semen Nelumbinis, Flos Chrysanthemi Indici 6 parts, Fructus Jujubae 6 parts, Flos Rosae Rugosae 6 parts and 2 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition for the treatment of of insomnia patients as claimed in claim 1, it is characterized in that, described Chinese medicine composition is made up of the raw material of following weight portion:
Herba Viticis Cannabifoliae 20 parts, Semen Myristicae 20 parts, Radix Polygalae 22 parts, Flos Farfarae 18 parts, Poria cum Radix Pini 18 parts, Radix Et Caulis Acanthopanacis Senticosi 16 parts, Arillus Longan 12 parts, Bulbus Lilii 14 parts, 12 parts, Semen Nelumbinis, Flos Chrysanthemi Indici 14 parts, Fructus Jujubae 12 parts, Flos Rosae Rugosae 12 parts and 10 parts, Radix Glycyrrhizae.
4. the Chinese medicine composition for the treatment of of insomnia patients as claimed in claim 1, it is characterized in that, described Chinese medicine composition is made up of the raw material of following weight portion:
Herba Viticis Cannabifoliae 15 parts, Semen Myristicae 15 parts, Radix Polygalae 16 parts, Flos Farfarae 15 parts, Poria cum Radix Pini 14 parts, Radix Et Caulis Acanthopanacis Senticosi 12 parts, Arillus Longan 10 parts, Bulbus Lilii 10 parts, 8 parts, Semen Nelumbinis, Flos Chrysanthemi Indici 10 parts, Fructus Jujubae 8 parts, Flos Rosae Rugosae 8 parts and 6 parts, Radix Glycyrrhizae.
5. the Chinese medicine composition of the treatment of insomnia patients as described in as arbitrary in claim 1-4, it is characterized in that, the preparation method of described Chinese medicine composition comprises following steps:
Step 1: take Herba Viticis Cannabifoliae, Semen Myristicae, Radix Polygalae, Poria cum Radix Pini and Radix Et Caulis Acanthopanacis Senticosi respectively in proportion, clean, crushed after being dried, merge coarse powder, adding coarse powder gross weight 8-10 times amount volume fraction is the ethanol of 60-80%, microwave extraction 8-15 minute, microwave power is 400-600W, and Extracting temperature is 40-60 DEG C, filters and retains filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained extract A;
Step 2: take Flos Farfarae, Arillus Longan, Bulbus Lilii, Semen Nelumbinis, Flos Chrysanthemi Indici, Fructus Jujubae, Flos Rosae Rugosae and Radix Glycyrrhizae respectively in proportion, pulverize after cleaning, drying, merge coarse powder, and merge with the filtering residue of step 1, add the water of medical material gross weight 8-12 times amount, reflux, extract, 2-3 time, each 3-6 hour, filter, merging filtrate, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained extract B;
Step 3: united extraction thing A and extract B, drying under reduced pressure, pulverizes, and crosses 80-100 mesh sieve, to obtain final product.
6. the Chinese medicine composition of the treatment of insomnia patients as described in as arbitrary in claim 1-4, it is characterized in that, described Chinese medicine composition is made into granule, tablet, capsule, pill, oral liquid or powder.
7. the preparation method of the Chinese medicine composition of the treatment of insomnia patients as described in as arbitrary in claim 1-4, is characterized in that, comprise following steps:
Step 1: take Herba Viticis Cannabifoliae, Semen Myristicae, Radix Polygalae, Poria cum Radix Pini and Radix Et Caulis Acanthopanacis Senticosi respectively in proportion, clean, crushed after being dried, merge coarse powder, adding coarse powder gross weight 8-10 times amount volume fraction is the ethanol of 60-80%, microwave extraction 8-15 minute, microwave power is 400-600W, and Extracting temperature is 40-60 DEG C, filters and retains filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained extract A;
Step 2: take Flos Farfarae, Arillus Longan, Bulbus Lilii, Semen Nelumbinis, Flos Chrysanthemi Indici, Fructus Jujubae, Flos Rosae Rugosae and Radix Glycyrrhizae respectively in proportion, pulverize after cleaning, drying, merge coarse powder, and merge with the filtering residue of step 1, add the water of medical material gross weight 8-12 times amount, reflux, extract, 2-3 time, each 3-6 hour, filter, merging filtrate, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained extract B;
Step 3: united extraction thing A and extract B, drying under reduced pressure, pulverizes, and crosses 80-100 mesh sieve, to obtain final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510965909.5A CN105477302A (en) | 2015-12-22 | 2015-12-22 | Insomnia treating traditional Chinese medicine composition and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510965909.5A CN105477302A (en) | 2015-12-22 | 2015-12-22 | Insomnia treating traditional Chinese medicine composition and preparation method thereof |
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| CN105477302A true CN105477302A (en) | 2016-04-13 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510965909.5A Withdrawn CN105477302A (en) | 2015-12-22 | 2015-12-22 | Insomnia treating traditional Chinese medicine composition and preparation method thereof |
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| Country | Link |
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| CN (1) | CN105477302A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107088215A (en) * | 2017-04-10 | 2017-08-25 | 广州绍康公生物科技有限责任公司 | A kind of herbaceous plant solid beverage of relieving insomnia symptom and preparation method thereof |
| CN115364156A (en) * | 2022-09-16 | 2022-11-22 | 塔里木大学 | Red date nerve-soothing composition as well as preparation method and application thereof |
-
2015
- 2015-12-22 CN CN201510965909.5A patent/CN105477302A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107088215A (en) * | 2017-04-10 | 2017-08-25 | 广州绍康公生物科技有限责任公司 | A kind of herbaceous plant solid beverage of relieving insomnia symptom and preparation method thereof |
| CN115364156A (en) * | 2022-09-16 | 2022-11-22 | 塔里木大学 | Red date nerve-soothing composition as well as preparation method and application thereof |
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Application publication date: 20160413 |