CN105362831A - Traditional Chinese medicine preparation for treating insomnia - Google Patents
Traditional Chinese medicine preparation for treating insomnia Download PDFInfo
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- CN105362831A CN105362831A CN201510910519.8A CN201510910519A CN105362831A CN 105362831 A CN105362831 A CN 105362831A CN 201510910519 A CN201510910519 A CN 201510910519A CN 105362831 A CN105362831 A CN 105362831A
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Abstract
The invention relates to a traditional Chinese medicine preparation for treating insomnia, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine preparation is prepared from the following raw materials: Radix Ophiopogonis, poria with hostwood, lophatherum gracile, flos farfarae, lily, lotus seeds, malt, poria cocos, cinnamon, red dates and liquorice. The traditional Chinese medicine preparation for treating insomnia has the effects of easing mental anxiety, tonifying the spleen and calming the heart, nourishing the blood and tranquilization and the like, treats both symptoms and root causes of the insomnia, and does not have toxic or side effects.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation for the treatment of of insomnia patients.
Background technology
Insomnia is due to feelings will, diet internal injury, and after being ill and old, innate deficiency, the causes of disease such as timidness due to deficiency of the heart, cause lack of preservation of spirit or irritability, thus cause often obtaining the class disease that ortho sleep is feature.Main manifestations is the length of one's sleep, the deficiency of the degree of depth and can not allaying tiredness, regain one's strength and energy, the lighter's difficulty falling asleep, or sleep but not soundly, sometimes sleeping and sometimes waking, or can not sleep again after waking up, heavy then be insomnia all night.Insomnia is one of common clinical card, though do not belong to critical illness, normal hinders people orthobiosis, work, study and health, and can increase the weight of or bring out the diseases such as cardiopalmus, the thoracic obstruction, dizzy, headache, apoplexy.Obstinate insomnia, brings long-term misery to patient, even form the dependence to sleeping medicine, and the sleeping medicine of long-term taking can cause iatrogenic disease.
Chinese medicine passes through the function of adjustment viscera negative and positive of qi and blood, often energy obviously improving water flood situation, and does not cause drug dependence and iatrogenic illness, thus rather well received.The principle of Chinese medicine Cure for insomnia is: at reinforce insufficiency and reduce excessiveness, and the basis of adjustment internal organs negative and positive of qi and blood is aided with the base therapy method that tranquilizing the mind is primary disease.The suitable reducing for the excess syndrome of excess syndrome, as dispersing the stagnated live-QI to relieve the stagnation of QI, pathogenic fire reducing clearing away phlegm, promoting digestion and regulating the middle JIAO.The suitable tonifying for deficiency syndrome of deficiency syndrome, as benefiting QI and nourishing blood, spleen invigorating, tonifying liver, kidney tonifying.With the passing of time, QI and blood consumption wound, also can transfer deficiency syndrome to, simulataneous insufficiency and excessive person to excess syndrome, and controlling should reinforcement and elimination in combination.The use of tranquilizing the mind method in conjunction with clinical, will be selected the concrete method for the treatment of such as nourishing blood to tranquillize the mind, tranquillizing the mind by relieving convulsion, clearing away heart-fire for tranquillization, and notes coordinating spiritual healing respectively, to eliminate nervous anxiety, keeps spirit happy.
At present, clinical treatment insomnia adopts the calm class medicine of Western medicine, can take effect rapidly at the initial stage of taking medicine, but these medicines also exist that side effect is large, Time of Administration long, the shortcoming of easily recurrence after drug withdrawal.Often take sleeping pill and not only can bring drug resistance, dependency, also can bring and be still drank after a night, withdrawal symptom, numerous adverse consequences such as memory impairment.Chinese traditional treatment mainly adopts the methods such as acupuncture, but the course for the treatment of is longer, takes effect not obvious.
Chinese patent application CN201410281941 discloses a kind of Chinese medicine of Cure for insomnia, certain weight ratio is pressed formulated by Yunnan-Tibet square bar cypress, Corallium Japonicum Kishinouye, Fructus Lycii, large thick branch moss, Semen Ziziphi Spinosae, Fructus Gardeniae, the Cortex Eucommiae, Cornu Saigae Tataricae, Semen Platycladi, the Rhizoma Atractylodis Macrocephalae, Folium Mori, Cortex Moutan, Bombyx Batryticatus, Fluoritum, Fructus Arctii and Spica Prunellae, this Drug therapy insomnia instant effect, effective percentage is high, but containing rare medical materials such as Yunnan-Tibet square bar cypress, Corallium Japonicum Kishinouye, Cornu Saigae Tataricae in medicament, adopt destructible ecological environment.
Summary of the invention
For solving the deficiencies in the prior art, the object of this invention is to provide a kind of Chinese medicine preparation for the treatment of of insomnia patients.
The Chinese medicine preparation for the treatment of of insomnia patients of the present invention is prepared from by the raw medicinal material of following weight portion: Radix Ophiopogonis 10-20, Poria cum Radix Pini 10-18, Herba Lophatheri 8-18, Flos Farfarae 10-16, Bulbus Lilii 8-18, Semen Nelumbinis 8-16, Fructus Hordei Germinatus 6-16, Poria 6-12, Cortex Cinnamomi 6-18, Fructus Jujubae 8-14 and Radix Glycyrrhizae 2-10.
Preferably, the Chinese medicine preparation for the treatment of of insomnia patients of the present invention is prepared from by the raw medicinal material of following weight portion: Radix Ophiopogonis 10, Poria cum Radix Pini 10, Herba Lophatheri 8, Flos Farfarae 10, Bulbus Lilii 8, Semen Nelumbinis 8, Fructus Hordei Germinatus 6, Poria 6, Cortex Cinnamomi 6, Fructus Jujubae 8 and Radix Glycyrrhizae 2.
Preferably, the Chinese medicine preparation for the treatment of of insomnia patients of the present invention is prepared from by the raw medicinal material of following weight portion: Radix Ophiopogonis 20, Poria cum Radix Pini 18, Herba Lophatheri 18, Flos Farfarae 16, Bulbus Lilii 18, Semen Nelumbinis 16, Fructus Hordei Germinatus 16, Poria 12, Cortex Cinnamomi 18, Fructus Jujubae 14 and Radix Glycyrrhizae 10.
Preferably, the Chinese medicine preparation for the treatment of of insomnia patients of the present invention is prepared from by the raw medicinal material of following weight portion: Radix Ophiopogonis 15, Poria cum Radix Pini 14, Herba Lophatheri 14, Flos Farfarae 12, Bulbus Lilii 12, Semen Nelumbinis 12, Fructus Hordei Germinatus 10, Poria 8, Cortex Cinnamomi 12, Fructus Jujubae 10 and Radix Glycyrrhizae 6.
Preferably, the Chinese medicine preparation for the treatment of of insomnia patients of the present invention is prepared from by the raw medicinal material of following weight portion: Radix Ophiopogonis 13, Poria cum Radix Pini 15, Herba Lophatheri 13, Flos Farfarae 13, Bulbus Lilii 14, Semen Nelumbinis 13, Fructus Hordei Germinatus 12, Poria 10, Cortex Cinnamomi 14, Fructus Jujubae 12 and Radix Glycyrrhizae 8.
Source, the nature and flavor of Chinese medicine preparation of the present invention Chinese crude drug used, return through and effect:
Radix Ophiopogonis: this product is the dried root of liliaceous plant Radix Ophiopogonis (dwarf lilyturf); Sweet in the mouth, micro-hardship, cold nature; GUIXIN, lung, stomach warp; YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.
Poria cum Radix Pini: this product is entertain the part of Radix Pini massonianae or fine core person in the middle of poria cocos sclerotium; Acrid in the mouth, hardship, property is put down; GUIXIN, kidney channel; Mind calming, calms the nerves, diuretic.
Herba Lophatheri: this product is the dry stem and leaf of grass Herba Lophatheri; Sweet in the mouth, light, cold in nature; GUIXIN, stomach, small intestine meridian; Clearing heat and relieving fidgetness, diuresis.
Flos Farfarae: this product is the dried floral of feverfew coltsfoot; Acrid in the mouth, micro-hardship, warm in nature; Return lung meridian; Nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm.
Bulbus Lilii: this product is the dry meat scale leaf of liliaceous plant tiger lily, Bulbus Lilii or Lilium tenuifolium; Sweet in the mouth, cold in nature; GUIXIN, lung meridian; Nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.
Semen Nelumbinis: this product is the dry mature seed of nymphaeaceae plant lotus; Sweet in the mouth, puckery, property is put down; Return spleen, kidney, heart channel; Spleen reinforcing antidiarrheal, kidney tonifying arresting seminal emission, tranquilizing by nourishing the heart.
Fructus Hordei Germinatus: this product is that the mature fruit of grass Fructus Hordei Vulgaris obtains through drying of germinateing; Sweet in the mouth, property is put down; Return spleen, stomach warp; Promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite.
Poria: this product is the dry sclerotia of On Polyporaceae Poria; Sweet in the mouth, light, property is put down; GUIXIN, lung, spleen, kidney channel; Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.
Cortex Cinnamomi: this product is the dry bark of canella Cortex Cinnamomi; Acrid in the mouth, sweet, extremely hot in nature; Return kidney, spleen, the heart, Liver Channel; Mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.
Fructus Jujubae: this product is the dry mature fruit of Rhamnaceae jujube Fructus Jujubae; Sweet in the mouth, warm in nature; Return spleen, stomach warp; Invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L.; Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The prescription analysis of Chinese medicine of the present invention:
Medicament composing prescription of the present invention is with Radix Ophiopogonis, Poria cum Radix Pini and Herba Lophatheri for monarch drug, and mind calming, calms the nerves, diuretic; With Flos Farfarae, Bulbus Lilii and Semen Nelumbinis for ministerial drug, nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization; With Fructus Hordei Germinatus, Poria, Cortex Cinnamomi and Fructus Jujubae adjuvant drug, spleen invigorating mind calming, nourishing blood to tranquillize the mind; With Radix Glycyrrhizae for making medicine, mind tranquilizing and the heart calming, coordinating the actions of various ingredients in a prescription; The all medicines of monarch coordinate, and collaborative promotion, complements each other, finally reach clearing away heart-fire for tranquillization, spleen invigorating mind calming, the effects such as nourishing blood to tranquillize the mind, treatment of insomnia patients is had to the effect for the treatment of both the principal and secondary aspects of a disease, have no side effect.
The present invention discloses a kind of method preparing the Chinese medicine preparation for the treatment of of insomnia patients, comprises the following steps:
S1: get Radix Ophiopogonis and clean, crushed after being dried, cross 60-80 mesh sieve, the coarse powder obtained is placed in supercritical carbon dioxide extraction apparatus, the 30-45% volume fraction adding coarse powder weight is the ethanol of 60-85%, regulation and control carbon dioxide flow is 15-20L/h, extracting pressure is 15-20MPa, and extraction temperature is 40-60 DEG C, and extraction time is 1.5-2h, decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis;
S2: take Poria cum Radix Pini, Poria, Flos Farfarae and Cortex Cinnamomi respectively in proportion, pulverize after cleaning, drying, merge coarse powder, add residue Radix Ophiopogonis, adding medical material gross weight 8-10 times amount volume fraction is the ethanol of 60-80%, microwave extraction 8-15 minute, and microwave power is 400-600W, Extracting temperature is 40-60 DEG C, filter and retain filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained extract A;
S3: take Herba Lophatheri, Bulbus Lilii, Semen Nelumbinis, Fructus Hordei Germinatus, Fructus Jujubae and Radix Glycyrrhizae respectively in proportion, pulverize after cleaning, drying, merge coarse powder, and merge with the filtering residue of step 2, add the water of medical material gross weight 8-12 times amount, reflux, extract, 2-3 time, each 3-6 hour, filter, merging filtrate, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained extract B;
S4: merge Radix Ophiopogonis extract, extract A and extract B, drying under reduced pressure, pulverizes, and crosses 80-100 mesh sieve, to obtain final product.
Preferably, above-mentioned Chinese medicine preparation is granule, tablet, capsule, pill, oral liquid or powder.
The present invention also discloses the purposes of above-mentioned Chinese medicine preparation in treatment of insomnia patients.
Compared with prior art, Chinese medicine preparation of the present invention has following advantage:
(1) compared with the Western medicine of Current therapeutic insomnia, Chinese medicine preparation of the present invention is made up of pure natural Chinese herbal medicine, all medicines work in coordination with, significantly reduce untoward reaction and toxic and side effects, have good effect, treating both the principal and secondary aspects of a disease, stress nurse one's health treatment advantage;
(2) Pharmacodynamic Data shows, Chinese medicine preparation of the present invention significantly reduces mice freely movable number of times, shortens mice sleep incubation period and Sleeping Time Prolong Ed and significant sedation, significantly can improve the symptom of insomnia; In addition, Chinese medicine preparation of the present invention has determined curative effect to clinical insomniac, and the advantage such as have no adverse reaction;
(3) simple and easy to do, the efficacy stability of Chinese medicine preparation preparation technology of the present invention, be easy to apply.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, be all included within the scope of the present invention.
eXAMPLE l
The embodiment of the present invention 1 Chinese medicine preparation is prepared from by the raw medicinal material of following weight portion: Radix Ophiopogonis 10, Poria cum Radix Pini 10, Herba Lophatheri 8, Flos Farfarae 10, Bulbus Lilii 8, Semen Nelumbinis 8, Fructus Hordei Germinatus 6, Poria 6, Cortex Cinnamomi 6, Fructus Jujubae 8 and Radix Glycyrrhizae 2.
Preparation method:
S1: get Radix Ophiopogonis and clean, crushed after being dried, cross 70 mesh sieves, the coarse powder obtained is placed in supercritical carbon dioxide extraction apparatus, 45% volume fraction adding coarse powder weight is the ethanol of 75%, regulation and control carbon dioxide flow is 20L/h, extracting pressure is 20MPa, and extraction temperature is 50 DEG C, and extraction time is 2h, decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis;
S2: take Poria cum Radix Pini, Poria, Flos Farfarae and Cortex Cinnamomi respectively in proportion, pulverize after cleaning, drying, merge coarse powder, add residue Radix Ophiopogonis, adding medical material gross weight 8 times amount volume fraction is the ethanol of 70%, microwave extraction 10 minutes, and microwave power is 500W, Extracting temperature is 50 DEG C, filter and retain filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10, obtained extract A;
S3: take Herba Lophatheri, Bulbus Lilii, Semen Nelumbinis, Fructus Hordei Germinatus, Fructus Jujubae and Radix Glycyrrhizae respectively in proportion, pulverize after cleaning, drying, merge coarse powder, and merge with the filtering residue of step 2, add the water of medical material gross weight 10 times amount, reflux, extract, 2 times, each 4 hours, filter, merging filtrate, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10, obtained extract B;
S4: merge Radix Ophiopogonis extract, extract A and B, drying under reduced pressure, pulverizes, and crosses 80 mesh sieves, obtains traditional Chinese medicine fine powder;
S5: the traditional Chinese medicine fine powder toward S4 gained adds suitable adjuvant, utilizes modern general preparation technique to be prepared into capsule.
embodiment 2
The embodiment of the present invention 2 Chinese medicine preparation is prepared from by the raw medicinal material of following weight portion: Radix Ophiopogonis 20, Poria cum Radix Pini 18, Herba Lophatheri 18, Flos Farfarae 16, Bulbus Lilii 18, Semen Nelumbinis 16, Fructus Hordei Germinatus 16, Poria 12, Cortex Cinnamomi 18, Fructus Jujubae 14 and Radix Glycyrrhizae 10.
Preparation method: with embodiment 1.
embodiment 3
The embodiment of the present invention 3 Chinese medicine preparation is prepared from by the raw medicinal material of following weight portion: Radix Ophiopogonis 15, Poria cum Radix Pini 14, Herba Lophatheri 14, Flos Farfarae 12, Bulbus Lilii 12, Semen Nelumbinis 12, Fructus Hordei Germinatus 10, Poria 8, Cortex Cinnamomi 12, Fructus Jujubae 10 and Radix Glycyrrhizae 6.
Preparation method: with embodiment 1.
embodiment 4
The embodiment of the present invention 4 Chinese medicine preparation is prepared from by the raw medicinal material of following weight portion: Radix Ophiopogonis 13, Poria cum Radix Pini 15, Herba Lophatheri 13, Flos Farfarae 13, Bulbus Lilii 14, Semen Nelumbinis 13, Fructus Hordei Germinatus 12, Poria 10, Cortex Cinnamomi 14, Fructus Jujubae 12 and Radix Glycyrrhizae 8.
Preparation method: with embodiment 1.
pharmacodynamics test
experimental example 1 Chinese medicine preparation of the present invention is tested the impact of spontaneous activity in mice
1, laboratory animal: get regular grade ICR mice 80, body weight 22-28g, male and female half and half, be divided into 8 groups at random, often organizes 10.
2, Experimental agents and dosage regimen:
A group: Experimental agents is the Chinese medicinal capsule that the embodiment of the present invention 3 obtains, and is divided into basic, normal, high 3 dosage groups.The using dosage of basic, normal, high dosage group is respectively 2g/kg, 4g/kg, 8g/kg, every day gavage 1 time.
B group: Experimental agents is the Chinese medicinal capsule that the embodiment of the present invention 4 obtains, and animal grouping and dosage regimen are with A group.
Normal group: get 1 group of rat, gavage equal-volume normal saline.
Positive controls: Experimental agents is hundred happy dormancy capsules (Yangzijiang Pharmaceutical Group Co., Ltd), and dosage is 8g/kg, every day gavage 1 time.
3, experimental technique: the continuous gavage 7d of mice, in last administration 8h fasting, front 1h prohibits water, gives 30min after mouse stomach, is placed in by mice in autonomic activities instrument, surveys the autonomic activities number of times of mice, and requirement of experiment detects in the environment of quiet, dark.Mice conforms 5min, the movable number of times of mice in counting 10min.
4, experimental result: as shown in table 1.
The comparison of the movable number of times of mice respectively organized by table 1
Note: compare with Normal group,
* p< 0.05,
* p< 0.01,
* * p< 0.001; Compare with positive controls,
# p< 0.05,
## p< 0.01,
### p< 0.001.
From upper table 1, Chinese medicine preparation of the present invention significantly reduce mice autonomic activities number of times (
p< 0.05), dosage is good dose-effect relationship, and the Chinese medicinal capsule effect that wherein A group, B group and embodiment 3, embodiment 4 are obtained is all fine.In addition, the middle and high dosage group of Chinese medicine preparation of the present invention compares with positive controls, all have significant difference (
p< 0.05), more excellent to the inhibition of mice autonomic activities.
experimental example 2 Chinese medicine preparation of the present invention is on the impact experiment of mice length of one's sleep incubation period of pentobarbital sodium process
1, laboratory animal: get regular grade ICR mice 80, body weight 22-28g, male and female half and half, be divided into 8 groups at random, often organizes 10.
2, Experimental agents and dosage regimen:
Administration group: the Chinese medicinal capsule that Experimental agents is the embodiment of the present invention 3, embodiment 4 obtains, is divided into basic, normal, high 3 dosage groups respectively.The using dosage of basic, normal, high dosage group is respectively 2g/kg, 4g/kg, 8g/kg, every day gavage 1 time.
Normal group: get 1 group of rat, gavage equal-volume normal saline.
Positive controls: Experimental agents is hundred happy dormancy capsules (Yangzijiang Pharmaceutical Group Co., Ltd), and dosage is 8g/kg, every day gavage 1 time.
3, experimental technique: mouse stomach administration 30min pneumoretroperitoneum injection pentobarbital sodium 30mg/kg(pentobarbital sodium injection threshold dose), observe sleep number of mice to calculate sleep mice percentage rate, and the length of one's sleep of recording sleep mice, (righting reflex loss was the length of one's sleep to the time of recovering.Righting reflex loss reaches at more than 1min, and person is defined as the positive, namely falls asleep).
4, experimental result: in table 2.
Table 2 Chinese medicine preparation of the present invention is on the impact of the pentobarbital sodium threshold dose length of one's sleep
Note: compare with Normal group,
* p< 0.05,
* p< 0.01; Compare with positive controls,
# p< 0.05.
From upper table 2, the obtained capsule of the embodiment of the present invention 3, embodiment 4 can significantly shorten the sleep latency of mice after injection threshold dose pentobarbital sodium and Sleeping Time Prolong Ed (
p< 0.05 or
p< 0.01), and the Be very effective of Chinese medicine preparation high dose group of the present invention be better than positive controls (
p< 0.05), the effect of middle dosage group and low dose group is suitable with positive controls.
the clinical experiment of experimental example 3 Chinese medicine preparation of the present invention
(1) study subject is selected
Tcm diagnosis standard
Following standard is formulated in the selected reference " insomnia definition, diagnosis and Drug therapy Consensus of experts (draft) " of reference clinical data case and " Chinese Spirit Obstacles classification and diagnostic criteria (CCMDD) ":
1. the long time for falling asleep of Sleep latency is more than 30min;
2. sleep maintains obstacle number of times of awakening night and is greater than 2 times;
3. shallow, the dreaminess of sleep quality decline sleep;
4. total sleep time shortening is less than 5 hours;
5. residual effect large sensation giddy in morning in the daytime, lassitude, drowsiness, weak etc.
Exclusion standard: 1. the age is under-18s, over-65s person; 2. severe physical illness and principal characteristic mental sickness person; 3. also with other drug and antipsychotic drug person; 4. serious suicidal attempt and actor is had; 5. gestation and women breast-feeding their children; 6. therapist is mismatched.
(2) clinical experiment scheme
1, physical data
By diagnostic criteria, the insomnia clinical volunteers patients that screening 400 example is medical, men and women half and half, age 25-55 year, 30 years old mean age, the course of disease 6 months-4 years.It is divided at random treatment A, B, C, D group and matched group five groups, often organizes each 80 examples.Each group of influence factor in sex, age, the course of disease, the state of an illness etc., through statistical procedures, without significant difference, has comparability.
2, Experimental agents and experimental technique
Treatment A, B, C, D group: take capsule prepared by the embodiment of the present invention 1,2,3,4 respectively, amount to crude drug content 0.35g/ grain, every day 2 times, each 2; Within 7 days, be a course for the treatment of, after taking for 4 courses for the treatment of continuously, evaluate curative effect.
Matched group: take hundred happy dormancy capsules (Yangzijiang Pharmaceutical Group Co., Ltd).Take according to suggestion taking dose (20mg/kg), 2 times on the one, within 7 days, be a course for the treatment of, after 4 courses for the treatment of, evaluate curative effect.
3, curative effect determinate standard
Diagnostic criteria is by the standard envisages of " guideline of clinical investigations of new Chinese medicine Cure for insomnia " in " new Chinese medicine guideline of clinical investigations ".
Recovery from illness: fall asleep smoothly, recover the length of one's sleep normal, or the length of one's sleep is at more than 6h, sleeps deep, its clinical symptoms disappears substantially.
Effective: sleep is clearly better, and the length of one's sleep increases more than 3h, Depth of sleep increases, and clinical symptoms makes moderate progress.
Effective: symptom alleviates, the length of one's sleep, comparatively front increase was less than 3h.
Invalid: after treatment, insomnia is not improved or instead adds severe one, and clinical symptoms is also not improved.
4, therapeutic outcome
Table 3 therapeutic effect
From upper table 3 result, matched group Drug therapy insomnia effect cure rate is 47.5%; And Chinese medicine preparation Cure for insomnia effect recovery from illness efficiency of the present invention is up to more than 60%, total effective rate reaches more than 90.0%, higher than the total effective rate of contrast medicine 81.2%, wherein optimum with the effect for the treatment of C group and embodiment 3.Clinical trial results proves Chinese medicine preparation Cure for insomnia Be very effective of the present invention, can be used as medicament for treating insomnia, has higher clinical generalization value.
Claims (6)
1. the Chinese medicine preparation of a treatment of insomnia patients, it is characterized in that, described Chinese medicine preparation is made up of the raw medicinal material of following weight portion: Radix Ophiopogonis 10-20, Poria cum Radix Pini 10-18, Herba Lophatheri 8-18, Flos Farfarae 10-16, Bulbus Lilii 8-18, Semen Nelumbinis 8-16, Fructus Hordei Germinatus 6-16, Poria 6-12, Cortex Cinnamomi 6-18, Fructus Jujubae 8-14 and Radix Glycyrrhizae 2-10.
2. the Chinese medicine preparation for the treatment of of insomnia patients as claimed in claim 1, it is characterized in that, described Chinese medicine preparation is made up of the raw medicinal material of following weight portion: Radix Ophiopogonis 10, Poria cum Radix Pini 10, Herba Lophatheri 8, Flos Farfarae 10, Bulbus Lilii 8, Semen Nelumbinis 8, Fructus Hordei Germinatus 6, Poria 6, Cortex Cinnamomi 6, Fructus Jujubae 8 and Radix Glycyrrhizae 2.
3. the Chinese medicine preparation for the treatment of of insomnia patients as claimed in claim 1, it is characterized in that, described Chinese medicine preparation is made up of the raw medicinal material of following weight portion: Radix Ophiopogonis 20, Poria cum Radix Pini 18, Herba Lophatheri 18, Flos Farfarae 16, Bulbus Lilii 18, Semen Nelumbinis 16, Fructus Hordei Germinatus 16, Poria 12, Cortex Cinnamomi 18, Fructus Jujubae 14 and Radix Glycyrrhizae 10.
4. the Chinese medicine preparation for the treatment of of insomnia patients as claimed in claim 1, it is characterized in that, described Chinese medicine preparation is made up of the raw medicinal material of following weight portion: Radix Ophiopogonis 15, Poria cum Radix Pini 14, Herba Lophatheri 14, Flos Farfarae 12, Bulbus Lilii 12, Semen Nelumbinis 12, Fructus Hordei Germinatus 10, Poria 8, Cortex Cinnamomi 12, Fructus Jujubae 10 and Radix Glycyrrhizae 6.
5. the Chinese medicine preparation for the treatment of of insomnia patients as claimed in claim 1, it is characterized in that, described Chinese medicine preparation is made up of the raw medicinal material of following weight portion: Radix Ophiopogonis 13, Poria cum Radix Pini 15, Herba Lophatheri 13, Flos Farfarae 13, Bulbus Lilii 14, Semen Nelumbinis 13, Fructus Hordei Germinatus 12, Poria 10, Cortex Cinnamomi 14, Fructus Jujubae 12 and Radix Glycyrrhizae 8.
6. the Chinese medicine preparation of the treatment of insomnia patients as described in any one of claim 1-5, is characterized in that: described Chinese medicine preparation is granule, tablet, capsule, pill, oral liquid or powder.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107518125A (en) * | 2016-06-22 | 2017-12-29 | 孙健 | A kind of formula and preparation method for sleeping jujube tea |
| CN108477607A (en) * | 2018-04-10 | 2018-09-04 | 李钟� | A kind of nutraceutical improving children and infantal sleeping |
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| CN107518125A (en) * | 2016-06-22 | 2017-12-29 | 孙健 | A kind of formula and preparation method for sleeping jujube tea |
| CN108477607A (en) * | 2018-04-10 | 2018-09-04 | 李钟� | A kind of nutraceutical improving children and infantal sleeping |
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