CN103156999A

CN103156999A - Medicament preparation for treating neurasthenia

Info

Publication number: CN103156999A
Application number: CN2013100804380A
Authority: CN
Inventors: 王河东; 高丹丹
Original assignee: Weihai Dongbao Pharmaceutical Co Ltd
Current assignee: Weihai Dongbao Pharmaceutical Co Ltd
Priority date: 2013-03-14
Filing date: 2013-03-14
Publication date: 2013-06-19
Anticipated expiration: 2033-03-14
Also published as: CN103156999B

Abstract

The invention relates to the field of medicament formulations, and in particular relates to a medicament preparation for treating neurasthenia. The medicament preparation is characterized by being prepared from the following bulk medicaments by weight: 150-250g of caulis polygoni multiflori, 60-120g of spina date seed, 30-60g of dwarf lilyturf tuber, 60-120g of lotus plumule, 90-120g of shizandra, 30-90g of Ccodonopsis pilosula, 120-150g of root of rehmannia, 60-120g of rehmannia glutinosa and 30-60g of Chinese angelica. The medicament preparation for treating neurasthenia disclosed by the invention can be applied to various neurasthenia caused by blood deficiency, qi deficiency, yin deficiency, and the like, has the effects of tuning brain and soothing nerves, promoting blood circulation and removing meridian obstruction, tonifying qi and nourishing yin, and has the advantages of low cost and obvious curative effect without dependence, addiction and toxic side effect.

Description

A kind ofly treat neurasthenic pharmaceutical preparation

Technical field

The invention belongs to technical field of Chinese medicines, relate to a kind of neurasthenic pharmaceutical preparation for the treatment of.

Background technology

The neurasthenia refers to that brain is due to long-term nervous and stress, thereby produce weakening of ergasia ability, its principal character is easily excitement and mental fatiguability of spirit, sleep disorder, hypomnesis, headache etc., with symptoms such as various body discomforts, course of disease delay, heavy when light during symptom, state of an illness fluctuation is normal relevant with socio-psychological factors.Most of cases are fallen ill between 16-40 year, both sexes morbidity number no significant difference, and the person of being engaged in mental work occupies the majority.Even primary disease reaches the several years many decades as dealing with improperly to delay.

It is reported, the neurasthenia is a kind of commonly encountered diseases, the frequently-occurring disease of neural psychiatric department.According to statistics, neurastheniac accounts for 10% of internal clinic number, accounts for 40% of neural psychiatric department number of the infected, especially in the urban area, nearly 2,000 ten thousand patients is arranged.according to estimates, China's neurasthenic drug market scale for the treatment of reaches 1,000,000,000～2,500,000,000 yuan, but on market, the neurasthenic medicine for the treatment of mostly is certain side effect and the higher Western medicine kind of cost now, and a lot of patients are by the sleeping pill treatment, the side effect that the long-term excessive use of sleeping pill produces is obvious to all, directly affect people's physical and mental health, directly bring spirit and burden economically for patient and family, therefore Chinese medicine health type treatment medicine will obtain the favor of extensive patients, some herbal species also appearred on market in recent years, although but its side effect of existing Chinese medicine is little, but therapeutic effect is not very desirable.

Summary of the invention

The objective of the invention is to overcome above-mentioned the deficiencies in the prior art, a kind of neurasthenic pharmaceutical preparation for the treatment of is provided.That stagnation of liver-QI, stagnation of QI blood deficiency, fire-transformation impairment of YIN, malaise are done according to the Chinese medical discrimination neurasthenia, therefore treat the necessary soothing liver-QI for relieving depression of neurasthenia, benefiting QI for activating blood circulation, YIN nourishing Fructus Alpiniae Oxyphyllae, tranquillizing and allaying excitement, and the pharmaceutical preparation in the present invention is according to the drug matching principle, effect with invigorating brain and relieving mental uneasiness, promoting blood circulation to remove obstruction in the collateral, QI invigorating, yin nourishing, its cost is low simultaneously, evident in efficacy, no dependence, addiction and toxic and side effects.

a kind ofly treat neurasthenic preparation, the weight that it is characterized in that crude drug is: Caulis Polygoni Multiflori 150-250 g, Semen Ziziphi Spinosae 60-120g, Radix Ophiopogonis 30-60g, Plumula Nelumbinis 60-120g, Fructus Schisandrae Chinensis 90-120g, Radix Codonopsis 30-90g, Radix Rehmanniae 120-150g, Radix Rehmanniae Preparata 60-120g, Radix Angelicae Sinensis 30-60g, with Caulis Polygoni Multiflori, Semen Ziziphi Spinosae, Radix Ophiopogonis, Plumula Nelumbinis, Fructus Schisandrae Chinensis, Radix Codonopsis, the Radix Rehmanniae, Radix Rehmanniae Preparata, pulverize and sieve after the Radix Angelicae Sinensis cold drying, decoct with water 2-3 time, collecting decoction filters, filter and concentrate to get thick paste, be placed into room temperature, add ethanol, placed 24 hours, filter, distilling under reduced pressure is to distinguishing the flavor of without alcohol, vacuum drying gets dry extract, with the broken adjuvant granulation that adds of dried cream powder.

The invention has the beneficial effects as follows: can be applied to various neurasthenias, as blood deficiency, the deficiency of vital energy, the caused neurasthenia of the deficiency of YIN, have the effect of invigorating brain and relieving mental uneasiness, promoting blood circulation to remove obstruction in the collateral, QI invigorating, yin nourishing, its cost is low simultaneously, evident in efficacy, no dependence, addiction and toxic and side effects.

The specific embodiment

The invention will be further described below in conjunction with embodiment:

embodiment 1: the present embodiment adopts Caulis Polygoni Multiflori, Semen Ziziphi Spinosae, Radix Ophiopogonis, Plumula Nelumbinis, Fructus Schisandrae Chinensis, Radix Codonopsis, the Radix Rehmanniae, Radix Rehmanniae Preparata, be prepared from when being classified as crude drug, its weight is: Caulis Polygoni Multiflori 200g, Semen Ziziphi Spinosae 80g, Radix Ophiopogonis 40g, Plumula Nelumbinis 80g, Fructus Schisandrae Chinensis 100g, Radix Codonopsis 60g, Radix Rehmanniae 120g, Radix Rehmanniae Preparata 100g, Radix Angelicae Sinensis 50g, with Caulis Polygoni Multiflori, Semen Ziziphi Spinosae, Radix Ophiopogonis, Plumula Nelumbinis, Fructus Schisandrae Chinensis, Radix Codonopsis, the Radix Rehmanniae, Radix Rehmanniae Preparata, pulverized 200 mesh sieves after the Radix Angelicae Sinensis cold drying, decoct with water 2-3 time, each 2-3 hour, collecting decoction filters, filtration is concentrated into 60 ℃ of survey relative densities 1.05～1.15 and gets thick paste, be placed into room temperature, adding ethanol makes ethanol content reach 75%, placed 24 hours, filter, distilling under reduced pressure is to distinguishing the flavor of without alcohol, vacuum drying gets dry extract, the broken adjuvant that adds of dried cream powder is made 1000.Drug specifications: every Chinese medicinal granule weight 0.25g that contains the aforementioned therapies neurasthenia; Usage and consumption: warm water is oral, one time 4, twice of every day.

In medicine of the present invention, Caulis Polygoni Multiflori: sweet, little hardship, flat, enter the heart, spleen, lung, Liver Channel, have nourishing heart, calm the nerves, nourish blood, the effect of nourishing YIN, dispelling wind and removing obstruction in the collateral, cure mainly clinically deficiency of YIN insufficiency of blood, restlessness of asrhenia type and insomnia, rheumatic arthralgia.The complex acid Semen Ziziphi Spinosae is grown the heart-yin, mind calming god; Join the Radix Rehmanniae, the nourishing YIN of nourishing blood; Join Radix Ophiopogonis, clear asthenic fire, the moon nourishes heart.Semen Ziziphi Spinosae: sweet, sour, flat, GUIXIN, spleen, liver, gallbladder meridian have the effect of nourishing conscience, calming the nerves, and are mainly used in clinically deficiency of YIN-blood, severe palpitation, insomnia forgetfulness." book on Chinese herbal medicine converges and says ": astringing QI is calmed the nerves, and flourish muscle is supported marrow, stomach function regulating activating the spleen.Radix Ophiopogonis: sweet, little hardship, be slightly cold, GUIXIN, lung, stomach warp have YIN nourishing and the production of body fluid promoting, and the effect that lung moistening clears away heart-fire is mainly used in dryness of the lung dry cough, and deficiency of YIN consumptive disease is coughed, the sore throat pharyngalgia, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.Join Fructus Schisandrae Chinensis, function yin nourishing arresting sweating is with controlling deficiency of YIN hyperhidrosis, cardiopalmus, chronic cough of deficiency lung.Plumula Nelumbinis: bitter, cold, nontoxic, enter the heart, kidney, lung meridian, have the effect of tranquilizing by nourishing the heart, be mainly used in clinically the insomniac of disarmony between the heart and kidney, hyperactivity of fire caused by deficiency of YIN.Fructus Schisandrae Chinensis: sour, sweet, warm, return lung, the heart, kidney channel, have a convergence astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, the effect of kidney calming is mainly used in improving the insomnia cardiopalmus of old deficiency of heart-blood, insufficiency of heart-QI, disarmony between the heart and kidney clinically.Radix Codonopsis: sweet, little acid, flat, return spleen, lung meridian, have invigorating the spleen and replenishing QI, the effect of spleen invigorating lung benefiting for Qi-tonifying drug commonly used clinically, is joined hematonic Radix Rehmanniae Preparata, Radix Angelicae Sinensis, be used for deficiency of both QI and blood, can QI invigorating, can enrich blood again, being usually used in the deficiency of vital energy can not hemopoietic, or blood deficiency is difficult activating QI, and see pale or sallow complexion, and weak, dizzy insomnia extremely.The Radix Rehmanniae: sweet, bitter, cold, GUIXIN, liver, kidney channel, clearing away heat and cooling blood, yin nourishing, the effect of promoting the production of body fluid.Radix Rehmanniae Preparata: sweet, tepor, return liver, kidney channel, the yin nourishing of enriching blood, the effect of life essence-filling, marrow-benefitting is the key medicine of the yin nourishing of enriching blood, the normal and same use of Radix Angelicae Sinensis, the treatment blood deficiency and yellow complexion, dizzy, cardiopalmus, insomnia and menoxenia etc.Radix Angelicae Sinensis: sweet, hot, bitter, return liver, the heart, spleen channel, have enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, the effect of moisturizing laxation.

But each raw material of the present invention also embodiment of the listed part by weight mixing of according to the form below is realized.Its processing technique is identical with embodiment 1.(unit: gram)

Embodiment	Caulis Polygoni Multiflori	Semen Ziziphi Spinosae	Radix Ophiopogonis	Plumula Nelumbinis	Fructus Schisandrae Chinensis	Radix Codonopsis	The Radix Rehmanniae	Radix Rehmanniae Preparata	Radix Angelicae Sinensis
										Two	150	120	30	120	120	30	150	60	60
Three	250	60	60	60	90	90	130	120	30

The present invention treats the Chinese medicine clinical observation of rheumatism:

1, case is selected 20 examples, male's 10 examples wherein, women's 10 examples.

1.1 include the case standard in

A. meet the symptomatic diagnosis standards such as differential diagnosis in tcm stagnation of liver-QI, stagnation of QI blood deficiency, fire-transformation impairment of YIN, malaise.

B. meet the diagnostic criteria of doctor trained in Western medicine neurasthenia symptom.

2, Therapeutic Method

Every day twice, each 4, warm water is oral, and 2 weeks were a course for the treatment of, takes altogether 6 courses for the treatment of.

3, criterion of therapeutical effect

A kind ofly treat neurasthenic pharmaceutical preparation curative effect and judge whether Main Basis disappears in symptoms such as dizziness that the neurasthenia causes, absent minded, susceptible to lose temper due to restlessness, lassitude, bradykinesia.Two weeks of medication are a course for the treatment of.Concrete curative effect is divided following level Four:

Cure: the symptoms such as dizzy, absent minded, susceptible to lose temper due to restlessness, lassitude, bradykinesia all disappear.

Produce effects: the symptom such as dizzy, absent minded, susceptible to lose temper due to restlessness, lassitude, bradykinesia is obviously alleviated.

Effectively: the symptom such as dizzy, absent minded, susceptible to lose temper due to restlessness, lassitude, bradykinesia is alleviated to some extent.

Invalid: the symptom such as dizzy, absent minded, susceptible to lose temper due to restlessness, lassitude, bradykinesia is without significant change.

4, therapeutic effect:

By after above-mentioned standard care, cure 14 examples, produce effects 3 examples, effective 2 examples, invalid 1 example, total effective rate 95%.

5, model case:

Open XX, the female, 31 years old, in April, 2010 was medical, and patient's readme the first two years is repeatedly suffered from neurasthenia, number of times is frequent in the recent period, and all day is dizzy, and can't fall asleep evening, and can not concentrate one's energy daytime, hypomnesis, bradykinesia, susceptible to lose temper due to restlessness, lassitude is diagnosed as blood deficiency type neurasthenic disease.Take pharmaceutical preparation of the present invention, took continuously for two weeks, symptom is obviously improved, and after taking two courses for the treatment of, symptom all disappears.

Claims

1. treat neurasthenic preparation for one kind, the weight that it is characterized in that crude drug is: Caulis Polygoni Multiflori 150-250g, Semen Ziziphi Spinosae 60-120g, Radix Ophiopogonis 30-60g, Plumula Nelumbinis 60-120g, Fructus Schisandrae Chinensis 90-120g, Radix Codonopsis 30-90g, Radix Rehmanniae 120-150g, Radix Rehmanniae Preparata 60-120g, Radix Angelicae Sinensis 30-60g, with Caulis Polygoni Multiflori, Semen Ziziphi Spinosae, Radix Ophiopogonis, Plumula Nelumbinis, Fructus Schisandrae Chinensis, Radix Codonopsis, the Radix Rehmanniae, Radix Rehmanniae Preparata, pulverize and sieve after the Radix Angelicae Sinensis cold drying, decoct with water 2-3 time, collecting decoction filters, filter and concentrate to get thick paste, be placed into room temperature, add ethanol, placed 24 hours, filter, distilling under reduced pressure is to distinguishing the flavor of without alcohol, vacuum drying gets dry extract, with the broken adjuvant granulation that adds of dried cream powder.