CN103156999B

CN103156999B - Medicament preparation for treating neurasthenia

Info

Publication number: CN103156999B
Application number: CN201310080438.0A
Authority: CN
Inventors: 王河东; 高丹丹
Original assignee: Weihai Dongbao Pharmaceutical Co Ltd
Current assignee: Weihai Dongbao Pharmaceutical Co Ltd
Priority date: 2013-03-14
Filing date: 2013-03-14
Publication date: 2014-06-25
Anticipated expiration: 2033-03-14
Also published as: CN103156999A

Abstract

The invention relates to the field of medicament formulations, and in particular relates to a medicament preparation for treating neurasthenia. The medicament preparation is characterized by being prepared from the following bulk medicaments by weight: 150-250g of caulis polygoni multiflori, 60-120g of spina date seed, 30-60g of dwarf lilyturf tuber, 60-120g of lotus plumule, 90-120g of shizandra, 30-90g of Ccodonopsis pilosula, 120-150g of root of rehmannia, 60-120g of rehmannia glutinosa and 30-60g of Chinese angelica. The medicament preparation for treating neurasthenia disclosed by the invention can be applied to various neurasthenia caused by blood deficiency, qi deficiency, yin deficiency, and the like, has the effects of tuning brain and soothing nerves, promoting blood circulation and removing meridian obstruction, tonifying qi and nourishing yin, and has the advantages of low cost and obvious curative effect without dependence, addiction and toxic side effect.

Description

One is treated neurasthenic pharmaceutical preparation

Technical field

The invention belongs to technical field of Chinese medicines, relate to one and treat neurasthenic pharmaceutical preparation.

Background technology

Neurasthenia refers to that brain is due to long-term nervous and stress, thereby produce weakening of ergasia ability, its principal character is easily excitement and mental fatiguability of spirit, sleep disorder, hypomnesis, headache etc., with symptoms such as various body discomforts, course of disease delay, heavy when light when symptom, state of an illness fluctuation is normal relevant with socio-psychological factors.Most of cases are fallen ill between 16-40 year, both sexes morbidity number no significant difference, and the person of being engaged in mental work occupies the majority.Even primary disease can be delayed and reach several years many decades as dealt with improperly.

It is reported, neurasthenia is a kind of commonly encountered diseases, the frequently-occurring disease of neural psychiatric department.According to statistics, neurastheniac accounts for 10% of internal clinic number, accounts for 40% of neural psychiatric department number of the infected, especially in urban area, has nearly 2,000 ten thousand patients.According to estimates, China treats neurasthenic drug market scale and reaches 1,000,000,000～2,500,000,000 yuan, but on market, treat neurasthenic medicine now and mostly be certain side effect and the higher Western medicine kind of cost, and a lot of patients are by sleeping pill treatment, the side effect that the long-term excessive use of sleeping pill produces is obvious to all, directly affect people's physical and mental health, directly bring spirit and burden economically to patient and family, therefore Chinese medicine health type treatment medicine will obtain the favor of extensive patients, on market, also there are in recent years some herbal species, although but its side effect of existing Chinese medicine is little, but therapeutic effect is not very desirable.

Summary of the invention

The object of the invention is to overcome above-mentioned the deficiencies in the prior art, provide one to treat neurasthenic pharmaceutical preparation.That stagnation of liver-QI, stagnation of QI blood deficiency, fire-transformation impairment of YIN, malaise are done according to Chinese medical discrimination neurasthenia, therefore treat the necessary soothing liver-QI for relieving depression of neurasthenia, benefiting QI for activating blood circulation, YIN nourishing Fructus Alpiniae Oxyphyllae, tranquillizing and allaying excitement, and pharmaceutical preparation in the present invention is according to drug matching principle, there is effect of invigorating brain and relieving mental uneasiness, promoting blood circulation to remove obstruction in the collateral, QI invigorating, yin nourishing, its cost is low simultaneously, evident in efficacy, no dependence, addiction and toxic and side effects.

One is treated neurasthenic preparation, the weight that it is characterized in that crude drug is: Caulis Polygoni Multiflori 150-250 g, Semen Ziziphi Spinosae 60-120g, Radix Ophiopogonis 30-60g, Plumula Nelumbinis 60-120g, Fructus Schisandrae Chinensis 90-120g, Radix Codonopsis 30-90g, Radix Rehmanniae 120-150g, Radix Rehmanniae Preparata 60-120g, Radix Angelicae Sinensis 30-60g, by Caulis Polygoni Multiflori, Semen Ziziphi Spinosae, Radix Ophiopogonis, Plumula Nelumbinis, Fructus Schisandrae Chinensis, Radix Codonopsis, the Radix Rehmanniae, Radix Rehmanniae Preparata, after Radix Angelicae Sinensis cold drying, pulverize and sieve, decoct with water 2-3 time, collecting decoction filters, filter and concentrate to obtain thick paste, be placed into room temperature, add ethanol, place 24 hours, filter, distilling under reduced pressure is extremely without alcohol taste, vacuum drying gets dry extract, by the broken dried cream powder adjuvant granulation that adds.

The invention has the beneficial effects as follows: can be applied to various neurasthenias, as blood deficiency, the deficiency of vital energy, the caused neurasthenia of the deficiency of YIN, there is effect of invigorating brain and relieving mental uneasiness, promoting blood circulation to remove obstruction in the collateral, QI invigorating, yin nourishing, its cost is low simultaneously, evident in efficacy, no dependence, addiction and toxic and side effects.

Detailed description of the invention

Below in conjunction with embodiment, the invention will be further described:

Embodiment 1: the present embodiment adopts Caulis Polygoni Multiflori, Semen Ziziphi Spinosae, Radix Ophiopogonis, Plumula Nelumbinis, Fructus Schisandrae Chinensis, Radix Codonopsis, the Radix Rehmanniae, Radix Rehmanniae Preparata, be prepared from when being classified as crude drug, its weight is: Caulis Polygoni Multiflori 200g, Semen Ziziphi Spinosae 80g, Radix Ophiopogonis 40g, Plumula Nelumbinis 80g, Fructus Schisandrae Chinensis 100g, Radix Codonopsis 60g, Radix Rehmanniae 120g, Radix Rehmanniae Preparata 100g, Radix Angelicae Sinensis 50g, by Caulis Polygoni Multiflori, Semen Ziziphi Spinosae, Radix Ophiopogonis, Plumula Nelumbinis, Fructus Schisandrae Chinensis, Radix Codonopsis, the Radix Rehmanniae, Radix Rehmanniae Preparata, after Radix Angelicae Sinensis cold drying, pulverized 200 mesh sieves, decoct with water 2-3 time, each 2-3 hour, collecting decoction filters, filtration is concentrated into 60 DEG C of survey relative densities 1.05～1.15 and obtains thick paste, be placed into room temperature, adding ethanol makes ethanol content reach 75%, place 24 hours, filter, distilling under reduced pressure is extremely without alcohol taste, vacuum drying gets dry extract, the broken dried cream powder adjuvant that adds is made to 1000.Drug specifications: every Chinese medicinal granule weight 0.25g containing aforementioned therapies neurasthenia; Usage and consumption: warm water is oral, one time 4, twice of every day.

In medicine of the present invention, Caulis Polygoni Multiflori: sweet, micro-hardship, flat, enter the heart, spleen, lung, Liver Channel, there is nourishing heart, calm the nerves, nourish blood, effect of nourishing YIN, dispelling wind and removing obstruction in the collateral, cure mainly clinically deficiency of YIN insufficiency of blood, restlessness of asrhenia type and insomnia, rheumatic arthralgia.Complex acid Semen Ziziphi Spinosae, grows the heart-yin, mind calming god; Join the Radix Rehmanniae, the nourishing YIN of nourishing blood; Join Radix Ophiopogonis, clear asthenic fire, the moon nourishes heart.Semen Ziziphi Spinosae: sweet, sour, flat, GUIXIN, spleen, liver, gallbladder meridian, have the effect of nourishing conscience, calming the nerves, and is mainly used in clinically deficiency of YIN-blood, severe palpitation, insomnia forgetfulness." book on Chinese herbal medicine converges and says ": astringing QI is calmed the nerves, and flourish muscle is supported marrow, stomach function regulating activating the spleen.Radix Ophiopogonis: sweet, micro-hardship, be slightly cold, GUIXIN, lung, stomach warp, have YIN nourishing and the production of body fluid promoting, and effect that lung moistening clears away heart-fire is mainly used in dryness of the lung dry cough, and deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.Join Fructus Schisandrae Chinensis, function yin nourishing arresting sweating, with controlling deficiency of YIN hyperhidrosis, cardiopalmus, chronic cough of deficiency lung.Plumula Nelumbinis: bitter, cold, nontoxic, enter the heart, kidney, lung meridian, there is effect of tranquilizing by nourishing the heart, be mainly used in clinically the insomniac of disarmony between the heart and kidney, hyperactivity of fire caused by deficiency of YIN.Fructus Schisandrae Chinensis: sour, sweet, warm, return lung, the heart, kidney channel, there is convergence astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, effect of kidney calming, is mainly used in improving the insomnia cardiopalmus of old deficiency of heart-blood, insufficiency of heart-QI, disarmony between the heart and kidney clinically.Radix Codonopsis: sweet, micro-acid, flat, return spleen, lung meridian, there is invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting, is conventional clinically Qi-tonifying drug, joins hematonic Radix Rehmanniae Preparata, Radix Angelicae Sinensis, for deficiency of both QI and blood, can QI invigorating, can enrich blood again, being usually used in the deficiency of vital energy can not hemopoietic, or blood deficiency is difficult activating QI, and see pale or sallow complexion, and weak, dizzy insomnia extremely.The Radix Rehmanniae: sweet, bitter, cold, GUIXIN, liver, kidney channel, clearing away heat and cooling blood, yin nourishing, the effect of promoting the production of body fluid.Radix Rehmanniae Preparata: sweet, tepor, return liver, kidney channel, the yin nourishing of enriching blood, effect of life essence-filling, marrow-benefitting, is the key medicine of the yin nourishing of enriching blood, the normal and same use of Radix Angelicae Sinensis, treatment blood deficiency and yellow complexion, dizzy, cardiopalmus, insomnia and menoxenia etc.Radix Angelicae Sinensis: sweet, pungent, bitter, return liver, the heart, spleen channel, have enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, the effect of moisturizing laxation.

The each raw material of the present invention also can according to the form below the embodiment that mixes of listed part by weight realize.Its processing technique is identical with embodiment 1.(unit: gram)

Embodiment	Caulis Polygoni Multiflori	Semen Ziziphi Spinosae	Radix Ophiopogonis	Plumula Nelumbinis	Fructus Schisandrae Chinensis	Radix Codonopsis	The Radix Rehmanniae	Radix Rehmanniae Preparata	Radix Angelicae Sinensis
										Two	150	120	30	120	120	30	150	60	60
Three	250	60	60	60	90	90	130	120	30

The present invention treats the Chinese medicine clinical observation of rheumatism:

1, case selection 20 examples, wherein male's 10 examples, women's 10 examples.

1.1 include case standard in

A. meet the symptomatic diagnosis standards such as differential diagnosis in tcm stagnation of liver-QI, stagnation of QI blood deficiency, fire-transformation impairment of YIN, malaise.

B. meet the diagnostic criteria of doctor trained in Western medicine neurasthenia symptom.

2, Therapeutic Method

Every day twice, each 4, warm water is oral, within 2 weeks, is a course for the treatment of, takes altogether 6 courses for the treatment of.

3, criterion of therapeutical effect

One is treated neurasthenic pharmaceutical preparation curative effect and is judged whether Main Basis disappears in symptoms such as dizziness that neurasthenia causes, absent minded, susceptible to lose temper due to restlessness, lassitude, bradykinesia.Medication two weeks is a course for the treatment of.Concrete curative effect is divided following level Four:

Cure: the symptoms such as dizzy, absent minded, susceptible to lose temper due to restlessness, lassitude, bradykinesia all disappear.

Effective: the symptom such as dizzy, absent minded, susceptible to lose temper due to restlessness, lassitude, bradykinesia is obviously alleviated.

Effective: the symptom such as dizzy, absent minded, susceptible to lose temper due to restlessness, lassitude, bradykinesia is alleviated to some extent.

Invalid: the symptom such as dizzy, absent minded, susceptible to lose temper due to restlessness, lassitude, bradykinesia is without significant change.

4, therapeutic effect:

By after above-mentioned standard care, cure 14 examples, effective 3 examples, effective 2 examples, invalid 1 example, total effective rate 95%.

5, model case:

Open XX, female, 31 years old, in April, 2010 was medical, and patient's readme the first two years is repeatedly suffered from neurasthenia, in the recent period number of times is frequent, all day dizziness, can't fall asleep evening, can not concentrate one's energy daytime, hypomnesis, bradykinesia, susceptible to lose temper due to restlessness, lassitude, is diagnosed as blood deficiency type neurasthenic disease.Take pharmaceutical preparation of the present invention, take continuously two weeks, symptom is obviously improved, and takes after two courses for the treatment of, and symptom all disappears.

Claims

1. the neurasthenic preparation for the treatment of, the weight that it is characterized in that crude drug is: Caulis Polygoni Multiflori 150-250g, Semen Ziziphi Spinosae 60-120g, Radix Ophiopogonis 30-60g, Plumula Nelumbinis 60-120g, Fructus Schisandrae Chinensis 90-120g, Radix Codonopsis 30-90g, Radix Rehmanniae 120-150g, Radix Rehmanniae Preparata 60-120g, Radix Angelicae Sinensis 30-60g, by Caulis Polygoni Multiflori, Semen Ziziphi Spinosae, Radix Ophiopogonis, Plumula Nelumbinis, Fructus Schisandrae Chinensis, Radix Codonopsis, the Radix Rehmanniae, Radix Rehmanniae Preparata, after Radix Angelicae Sinensis cold drying, pulverize and sieve, decoct with water 2-3 time, collecting decoction filters, filter and concentrate to obtain thick paste, be placed into room temperature, add ethanol, place 24 hours, filter, distilling under reduced pressure is extremely without alcohol taste, vacuum drying gets dry extract, by the broken dried cream powder adjuvant granulation that adds.