CN104873879A - Medicinal preparation for treating insomnia - Google Patents
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- CN104873879A CN104873879A CN201510350702.7A CN201510350702A CN104873879A CN 104873879 A CN104873879 A CN 104873879A CN 201510350702 A CN201510350702 A CN 201510350702A CN 104873879 A CN104873879 A CN 104873879A
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- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 title claims abstract description 25
- 206010022437 insomnia Diseases 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000003814 drug Substances 0.000 claims abstract description 20
- 210000000582 semen Anatomy 0.000 claims abstract description 10
- 241000218176 Corydalis Species 0.000 claims abstract description 7
- 210000003038 endothelium Anatomy 0.000 claims abstract description 7
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 25
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 13
- 239000008187 granular material Substances 0.000 claims description 11
- 239000012567 medical material Substances 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 9
- 206010033799 Paralysis Diseases 0.000 claims description 7
- 239000002775 capsule Substances 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 239000007921 spray Substances 0.000 claims description 5
- 238000001694 spray drying Methods 0.000 claims description 5
- 238000005507 spraying Methods 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 239000003826 tablet Substances 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 3
- 239000002552 dosage form Substances 0.000 claims description 2
- 244000296912 Ageratum conyzoides Species 0.000 abstract description 2
- 235000004405 Ageratum conyzoides Nutrition 0.000 abstract 1
- 241000049464 Artemisia apiacea Species 0.000 abstract 1
- 235000011570 Artemisia caruifolia var apiacea Nutrition 0.000 abstract 1
- 241000092665 Atractylodes macrocephala Species 0.000 abstract 1
- 241000037740 Coptis chinensis Species 0.000 abstract 1
- 241000305491 Gastrodia elata Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 241000237502 Ostreidae Species 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 244000197580 Poria cocos Species 0.000 abstract 1
- 235000017307 Severinia buxifolia Nutrition 0.000 abstract 1
- 244000213205 Severinia buxifolia Species 0.000 abstract 1
- 235000004879 dioscorea Nutrition 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
- 235000020636 oyster Nutrition 0.000 abstract 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
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- 208000024891 symptom Diseases 0.000 description 3
- 208000019901 Anxiety disease Diseases 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 230000036506 anxiety Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
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- 239000008107 starch Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000002936 tranquilizing effect Effects 0.000 description 2
- 206010007134 Candida infections Diseases 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010007882 Cellulitis Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 241000447394 Desmos Species 0.000 description 1
- 244000171168 Desmos chinensis Species 0.000 description 1
- 241000926826 Desmos cochinchinensis Species 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 208000000913 Kidney Calculi Diseases 0.000 description 1
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- 206010028980 Neoplasm Diseases 0.000 description 1
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- 206010030113 Oedema Diseases 0.000 description 1
- 208000007027 Oral Candidiasis Diseases 0.000 description 1
- 206010033078 Otitis media Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 241000287411 Turdidae Species 0.000 description 1
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- 208000006568 Urinary Bladder Calculi Diseases 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 208000012873 acute gastroenteritis Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
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- 235000019425 dextrin Nutrition 0.000 description 1
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- 238000003306 harvesting Methods 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
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- 231100000957 no side effect Toxicity 0.000 description 1
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- 230000004622 sleep time Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
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- 231100000397 ulcer Toxicity 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the field of traditional Chinese medicine preparations, and particularly provides a medicinal preparation for treating insomnia. The medicinal preparation is prepared from the following raw materials of 25 parts of atalantia buxifolia, 18 parts of ageratum conyzoides, 20 parts of poria cocos, 15 parts of semen coicis, 15 parts of fructus lycii, 30 parts of oysters, 20 parts of spina date seeds, 10 parts of cimicifugae foetidae, 10 parts of rhizoma corydalis, 20 parts of fushen, 10 parts of Chinese yams, 10 parts of gastrodia elata, 10 parts of endothelium corneum gigeriae galli, 3 parts of fructus amomi, 5 parts of coptis chinensis, 10 parts of salviae miltiorrhizae, 10 parts of atractylodes macrocephala koidz, 15 parts of radix paeoniae alba, 30 parts of fossil fragments, 10 parts of rhizoma acori graminei, 5 parts of liquorice, 10 parts of artemisia apiacea and 5 parts of radix gentianae. The medicinal preparation is used for treating insomnia.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of insomnia and its preparation method and application.
Background technology
Insomnia refers to fall asleep and maybe cannot keep sleep state, causes not having enough sleep.Also known as DIMS, for a variety of causes cause that difficulty falling asleep, Depth of sleep or frequency are too short, early awakening and the length of one's sleep not enough or of poor quality etc., be a kind of commonly encountered diseases.Insomnia often brings painful and psychological burden greatly to patient, can damage other every aspects of health again because of abuse insomnia drug.For this reason, the needs that the medicine developing more Cure for insomnias safely and effectively meets clinical treatment are bursting to.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of can the Chinese medicine preparation for the treatment of insomnia.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of insomnia, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: curled paralysis 25 parts, Herba Agerati Conyzoidis 18 parts, 20 parts, Poria, Semen Coicis 15 parts, Fructus Lycii 15 parts, Concha Ostreae 30 parts, Semen Ziziphi Spinosae 20 parts, Rhizoma Cimicifugae 10 parts, Rhizoma Corydalis 10 parts, Poria cum Radix Pini 20 parts, Rhizoma Dioscoreae 10 parts, 10 parts, Rhizoma Gastrodiae, Endothelium Corneum Gigeriae Galli 10 parts, Fructus Amomi 3 parts, Rhizoma Coptidis 5 parts, Radix Salviae Miltiorrhizae 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, the Radix Paeoniae Alba 15 parts, Os Draconis 30 parts, Rhizoma Acori Graminei 10 parts, 5 parts, Radix Glycyrrhizae, Herba Artemisiae Annuae 10 parts, Plumula Nelumbinis 5 parts.
The described pharmaceutical preparation being used for the treatment of insomnia, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of insomnia, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The application in medicament for treating insomnia is being prepared in the described pharmaceutical preparation being used for the treatment of insomnia.
Curled paralysis is annonaceae Desmos Lour Desmos chinensis Desmos cochinchinensis Lour., is used as medicine with root and Herb.The whole year can adopt, and clean chopping is dried.Expelling wind and removing dampness, spleen invigorating is regulated the flow of vital energy, stasis-dispelling and pain-killing.For rheumatic arthritis, puerperal exposure to wind pain, puerperal abdonimal pain, bleed more than, dysmenorrhea, stomachache, stomachache, abdominal distention, dyspepsia, diarrhoea, oedema due to nephritis, traumatic injury.The present invention is used as medicine with Herb.
Herba Agerati Conyzoidis is Compositae Ageratum plant Ageratum conyzoides Ageratum conyzoides L., is used as medicine with herb or leaf and tender stem.Xia Qiu gathers, and cleans, using fresh herb or dry.Pungent, micro-hardship, cool.Expelling wind and clearing away heat, pain relieving, hemostasis, calculus.For upper respiratory tract infection, tonsillitis, pharyngolaryngitis, acute gastroenteritis, stomachache, stomachache, metrorrhagia, renal calculus, vesical calculus; Eczema is controlled in external, thrush, carbuncle pyogenic infections from tumour or sore, cellulitis, ulcer of the lower limb, otitis media, traumatic hemorrhage.The present invention is with all herbal medicine.All the other medical materials are pharmacopeia kind.
Beneficial effect: curled paralysis of the present invention, Herba Agerati Conyzoidis, Poria, Semen Coicis, Fructus Lycii, Concha Ostreae, Semen Ziziphi Spinosae, Rhizoma Cimicifugae, Rhizoma Corydalis, Poria cum Radix Pini, Plumula Nelumbinis are monarch drug tranquillizing and allaying excitement, Rhizoma Dioscoreae, Rhizoma Gastrodiae, Endothelium Corneum Gigeriae Galli, Fructus Amomi, Rhizoma Coptidis, Radix Salviae Miltiorrhizae, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Os Draconis, Rhizoma Acori Graminei are ministerial drug, strengthen monarch drug tranquilizing effect, Radix Glycyrrhizae, Herba Artemisiae Annuae are adjuvant, the mutual compatibility of full side, Cure for insomnia successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get curled paralysis 25g, Herba Agerati Conyzoidis 18g, Poria 20g, Semen Coicis 15g, Fructus Lycii 15g, Concha Ostreae 30g, Semen Ziziphi Spinosae 20g, Rhizoma Cimicifugae 10g, Rhizoma Corydalis 10g, Poria cum Radix Pini 20g, Rhizoma Dioscoreae 10g, Rhizoma Gastrodiae 10g, Endothelium Corneum Gigeriae Galli 10g, Fructus Amomi 3g, Rhizoma Coptidis 5g, Radix Salviae Miltiorrhizae 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Paeoniae Alba 15g, Os Draconis 30g, Rhizoma Acori Graminei 10g, Radix Glycyrrhizae 5g, Herba Artemisiae Annuae 10g, Plumula Nelumbinis 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get curled paralysis 25g, Herba Agerati Conyzoidis 18g, Poria 20g, Semen Coicis 15g, Fructus Lycii 15g, Concha Ostreae 30g, Semen Ziziphi Spinosae 20g, Rhizoma Cimicifugae 10g, Rhizoma Corydalis 10g, Poria cum Radix Pini 20g, Rhizoma Dioscoreae 10g, Rhizoma Gastrodiae 10g, Endothelium Corneum Gigeriae Galli 10g, Fructus Amomi 3g, Rhizoma Coptidis 5g, Radix Salviae Miltiorrhizae 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Paeoniae Alba 15g, Os Draconis 30g, Rhizoma Acori Graminei 10g, Radix Glycyrrhizae 5g, Herba Artemisiae Annuae 10g, Plumula Nelumbinis 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
3, the preparation of capsule embodiment: get curled paralysis 25g, Herba Agerati Conyzoidis 18g, Poria 20g, Semen Coicis 15g, Fructus Lycii 15g, Concha Ostreae 30g, Semen Ziziphi Spinosae 20g, Rhizoma Cimicifugae 10g, Rhizoma Corydalis 10g, Poria cum Radix Pini 20g, Rhizoma Dioscoreae 10g, Rhizoma Gastrodiae 10g, Endothelium Corneum Gigeriae Galli 10g, Fructus Amomi 3g, Rhizoma Coptidis 5g, Radix Salviae Miltiorrhizae 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Paeoniae Alba 15g, Os Draconis 30g, Rhizoma Acori Graminei 10g, Radix Glycyrrhizae 5g, Herba Artemisiae Annuae 10g, Plumula Nelumbinis 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, pharmaceutical preparation Cure for insomnia of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation insomnia case 100 example, wherein man 50 example, female 50 example, 24 ~ 58 years old age.The shortest person of the course of disease 4 months, most elder reaches 3 years, average 1.8 years.
4.2 diagnostic criterias: (1) is slight: accidental, little to Quality of Life; (2) moderate: occur every night, moderate influence quality of life, accompanies certain symptom (irritability, anxiety, tired etc.); (3) severe: occur every night, has a strong impact on quality of life, and clinical symptoms is had outstanding performance.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: (1) clinical recovery: sleep is normal, more than the 6 hours length of one's sleep, simultaneous phenomenon disappears; (2) effective: total sleep time extends more than 2 hours, but less than 6 hours, simultaneous phenomenon improved; (3) invalid: before sleeping as taking medicine, or extend the length of one's sleep less than 2 hours, symptom is without improvement.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Take a turn for the better | Invalid | Total effective rate (%) |
| Treatment group | 50 | 19 | 27 | 4 | 92 |
| Blank group | 50 | 2 | 3 | 45 | 10 |
Visible, the medicine that the present invention obtains can safe and effective Cure for insomnia, and has no side effect.
4.6 Zhangs, female, 27 years old, the length of one's sleep, every night less than 2 hours, cannot fall asleep after waking up frequent midnight again, and companion's anxiety, continues 6 wheat harvesting periods.Take 4 courses for the treatment of of pharmaceutical preparation granule of the present invention, be increased to 8 hours the length of one's sleep; Continue to strengthen 2 courses for the treatment of, ensure sleep more than 8 hours every day, with other transference cures.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of insomnia, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: curled paralysis 25 parts, Herba Agerati Conyzoidis 18 parts, 20 parts, Poria, Semen Coicis 15 parts, Fructus Lycii 15 parts, Concha Ostreae 30 parts, Semen Ziziphi Spinosae 20 parts, Rhizoma Cimicifugae 10 parts, Rhizoma Corydalis 10 parts, Poria cum Radix Pini 20 parts, Rhizoma Dioscoreae 10 parts, 10 parts, Rhizoma Gastrodiae, Endothelium Corneum Gigeriae Galli 10 parts, Fructus Amomi 3 parts, Rhizoma Coptidis 5 parts, Radix Salviae Miltiorrhizae 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, the Radix Paeoniae Alba 15 parts, Os Draconis 30 parts, Rhizoma Acori Graminei 10 parts, 5 parts, Radix Glycyrrhizae, Herba Artemisiae Annuae 10 parts, Plumula Nelumbinis 5 parts.
2. be used for the treatment of the pharmaceutical preparation of insomnia as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of insomnia as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in medicament for treating insomnia of insomnia according to claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510350702.7A CN104873879A (en) | 2015-06-24 | 2015-06-24 | Medicinal preparation for treating insomnia |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510350702.7A CN104873879A (en) | 2015-06-24 | 2015-06-24 | Medicinal preparation for treating insomnia |
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| CN104873879A true CN104873879A (en) | 2015-09-02 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105343325A (en) * | 2015-12-04 | 2016-02-24 | 陈雪琴 | Traditional Chinese medicinal preparation for treating insomnia as well as preparation method and application of traditional Chinese medicinal preparation |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013053144A (en) * | 2011-08-09 | 2013-03-21 | Daiichi Sankyo Healthcare Co Ltd | Sedative composition |
| CN103800789A (en) * | 2012-11-06 | 2014-05-21 | 北京长城制药厂 | Traditional Chinese medicine composition for invigorating spleen and tonifying kidney and preparing method thereof |
| CN104383130A (en) * | 2014-11-29 | 2015-03-04 | 李洋 | Traditional Chinese medicine composition for treating insomnia as well as preparation method and application thereof |
-
2015
- 2015-06-24 CN CN201510350702.7A patent/CN104873879A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013053144A (en) * | 2011-08-09 | 2013-03-21 | Daiichi Sankyo Healthcare Co Ltd | Sedative composition |
| CN103800789A (en) * | 2012-11-06 | 2014-05-21 | 北京长城制药厂 | Traditional Chinese medicine composition for invigorating spleen and tonifying kidney and preparing method thereof |
| CN104383130A (en) * | 2014-11-29 | 2015-03-04 | 李洋 | Traditional Chinese medicine composition for treating insomnia as well as preparation method and application thereof |
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| 何洪霞: "联合治疗失眠四法", 《中国实用医药》 * |
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| 梁勇才: "《失眠防治实效方》", 31 January 2009, 化学工业出版社 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105343325A (en) * | 2015-12-04 | 2016-02-24 | 陈雪琴 | Traditional Chinese medicinal preparation for treating insomnia as well as preparation method and application of traditional Chinese medicinal preparation |
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