CN103599403B - Traditional Chinese medicine composition for treating migraine and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating migraine and preparation method thereof Download PDFInfo
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- CN103599403B CN103599403B CN201310630695.7A CN201310630695A CN103599403B CN 103599403 B CN103599403 B CN 103599403B CN 201310630695 A CN201310630695 A CN 201310630695A CN 103599403 B CN103599403 B CN 103599403B
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Abstract
The invention belongs to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating migraine and a preparation method thereof. The traditional Chinese medicine composition is composed for the following bulk drugs: radix bupleuri, angelica dahurica, Chinese angelica, atractylodes macrocephala, poria cocos, ligusticum chuanxiong, rhizoma gastrodiae, radix paeoniae rubra, radix paeoniae alba, chrysanthemum, mint, salvia miltiorrhiza and fructus viticis. The traditional Chinese medicine composition is prepared into tablets, capsules or granula according to a traditional Chinese medicine preparation method. The traditional Chinese medicine composition is reasonable in prescription, substantial in curative effect, none in side effect and high in safety.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to one and treat migrainous Chinese medicine composition and preparation method thereof.
Background technology
Migraine is clinical modal primary headache type; clinical with ictal middle severe, sample of beating headache for main manifestations, headache mostly be inclined side, generally continue 4 ~ 72 hours; can with Nausea and vomiting; light, Sound stimulat or daily routines all can increase the weight of headache, and quiet environment, rest can alleviate headache, but the migrainous cause of disease is more complicated; performance also presents variation; mostly the medicine of current clinical treatment is relief of symptoms, plays certain analgesic effect, cures the symptoms, not the disease.
Summary of the invention
The object of the invention is to make up the deficiencies in the prior art, the migrainous Chinese medicine composition for the treatment of that a kind of prescription is reasonable, index is effected a permanent cure again is provided.
The migrainous medicine for the treatment of of the present invention, is made up of the crude drug of following weight proportion:
Radix Bupleuri 8-15 part, Radix Angelicae Dahuricae 5-10 part, Radix Angelicae Sinensis 8-15 part, Rhizoma Atractylodis Macrocephalae 8-15 part, Poria 8-15 part, Rhizoma Chuanxiong 8-15 part, Rhizoma Gastrodiae 5-10 part, Radix Paeoniae Rubra 10-15 part, Radix Paeoniae Alba 10-15 part, Flos Chrysanthemi 10-15 part, Herba Menthae 3-8 part, Radix Salviae Miltiorrhizae 15-20 part, Fructus Viticis 10-20 part.
Its preferred each crude drug weight ratio is:
Radix Bupleuri 10 parts, the Radix Angelicae Dahuricae 8 parts, Radix Angelicae Sinensis 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, 10 parts, Poria, Rhizoma Chuanxiong 10 parts, 8 parts, Rhizoma Gastrodiae, Radix Paeoniae Rubra 12 parts, the Radix Paeoniae Alba 12 parts, Flos Chrysanthemi 12 parts, Herba Menthae 5 parts, Radix Salviae Miltiorrhizae 18 parts, Fructus Viticis 15 parts.
Above-mentioned Chinese medicine composition of the present invention adds the adjuvant prepared needed for preparation, can be prepared into tablet, capsule or granule.
Usage and dosage: dosage of the present invention depends on concrete dosage form, simultaneously should according to factors such as patient age, body weight and health status.As guidance: for oral administration, tablet: once a day, each 2, every sheet content of dispersion 0.5 gram, warm water takes; Capsule: once a day, each 3, every content of dispersion 0.4 gram, warm water takes; Granule: twice daily, each 5 grams, warm water takes.
In the present invention, the pharmacological action of each crude drug is as follows:
Radix Bupleuri: another name: ground is smoked, eggplant grass, HERBA BUPLEURI, RADIX BUPLEURI SCORZONERIFOLII, black Radix Bupleuri.Hardship, is slightly cold.Return liver, gallbladder meridian.Reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.
The Radix Angelicae Dahuricae: another name: Qi Baizhi, Yu Baizhi, celery of galloping along on horseback, the meeting Radix Angelicae Dahuricae, fragrant Radix Angelicae Dahuricae (Radix Heraclei Scabridi).Pungent, temperature.Return stomach, large intestine, lung meridian.Loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.For headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.
Radix Angelicae Sinensis: another name: dryly to return.Sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
The Rhizoma Atractylodis Macrocephalae: another name: what art, mountain Ji, yellor rocket, Rhizoma Atractylodis Macrocephalae.Bitter, sweet, temperature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.
Poria: sweet, light is flat.GUIXIN, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating, calms the nerves.Cure mainly edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Rhizoma Chuanxiong: another name: Ligusticum slnense.Pungent, temperature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea , mass in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Rhizoma Gastrodiae: another name: the winter is numb, the spring is numb.Sweet, flat.Return Liver Channel.Suppressing the hyperactive liver to relieve the wind syndrome relieving convulsion.Dizzy for having a headache, numb limbs and tense tendons, infantile convulsion, epilepsy clonus, tetanus.
Radix Paeoniae Rubra: another name: wooden Radix Paeoniae, red Radix Paeoniae, Radix Paeoniae Rubra.Hardship, is slightly cold.Return Liver Channel.Clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, { note of the ancient Chinese } abdominal mass is suffered from abdominal pain, injury from falling down, carbuncle skin infection.
The Radix Paeoniae Alba: another name: Radix Paeoniae Alba, golden Radix Paeoniae.Bitter, sour, be slightly cold.Return liver, spleen channel.Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Flos Chrysanthemi: another name: longevity visitor, Jin Ying, Huang Hua, Jin Rui.Sweet, bitter, be slightly cold.Return lung, Liver Channel.Loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.
Herba Menthae: another name: HERBA MENTHAE, water mint, core Adiantum monochlamys Eaton., luxuriant lotus dish, Herba Menthae Rotundifoliae.: pungent, cool.Return lung, Liver Channel.Dispelling wind-heat.Refresh oneself, rash.For anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, breast the side of body feeling of distension and oppression.
Radix Salviae Miltiorrhizae: another name: Arisaema balansae Engl., Radix Salviae Miltiorrhizae, Radix Campylotropis Hirtella (Herba Myrsines Africanae), wooden Lac caprae seu ovis.Hardship, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, { note of the ancient Chinese } abdominal mass is gathered, breast ventral spine pain, pyretic arthralgia pain, and skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Fructus Viticis: another name: wild pepper reality, Fructus Vitics Simplicifoliae, Folium Populi Albae, calico chaste tree.Pungent, bitter, be slightly cold.Return bladder, liver, stomach warp.Dispelling wind and heat pathogens, the clear sharp head.For anemopyretic cold headache, gingivitis, the many tear of conjunctival congestion, poor vision, has a dizzy spell.
It is be used for the treatment of migraine that the function of Chinese medicine composition of the present invention cures mainly, and Chinese medical discrimination belongs to caused by hepatic stagnation qi stagnation.Disease sees to have a headache in inclined side, or left or right, is distending pain, dull pain or pain of fighting more, companion's nausea and vomiting, fullness and distention in the chest and hypochondrium, irritable, constipation with dry stool, thin white fur of tongue, stringy pulse.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, but following examples are not limitation of the present invention.
embodiment 1: the preparation of tablet
Each raw material is taken: Radix Bupleuri 10 parts, the Radix Angelicae Dahuricae 8 parts, Radix Angelicae Sinensis 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, 10 parts, Poria, Rhizoma Chuanxiong 10 parts, 8 parts, Rhizoma Gastrodiae, Radix Paeoniae Rubra 12 parts, the Radix Paeoniae Alba 12 parts, Flos Chrysanthemi 12 parts, Herba Menthae 5 parts, Radix Salviae Miltiorrhizae 18 parts, Fructus Viticis 15 parts according to following weight portion;
Add 4 times of water soakings 2 hours, decoct 2 times, 1.5 hours first times, second time 1 hour collecting decoction, filter, filtrate is concentrated into the thick paste that relative density is 1.08, low-temperature bake 10 hours, and get dry extract powder;
Get dried cream powder in proportion, cross 80 mesh sieves, prepare soft material with the starch slurry of 5%, 16 mesh sieves are granulated, and wet granular was 40 DEG C of dryings 2 hours, and 14 mesh sieve granulate, add Pulvis Talci mix homogeneously, then tabletted.
embodiment 2: the preparation of capsule
Each raw material is taken: Radix Bupleuri 10 parts, the Radix Angelicae Dahuricae 8 parts, Radix Angelicae Sinensis 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, 10 parts, Poria, Rhizoma Chuanxiong 10 parts, 8 parts, Rhizoma Gastrodiae, Radix Paeoniae Rubra 12 parts, the Radix Paeoniae Alba 12 parts, Flos Chrysanthemi 12 parts, Herba Menthae 5 parts, Radix Salviae Miltiorrhizae 18 parts, Fructus Viticis 15 parts according to following weight portion;
Add 4 times of water soakings 2 hours, decoct 2 times, 1.5 hours first times, second time 1 hour collecting decoction, filter, filtrate is concentrated into the thick paste that relative density is 1.08, low-temperature bake 10 hours, and get dry extract powder;
Get dried cream powder in proportion, with appropriate amount of starch slurry soft material processed, granulate, dry, granulate, incapsulates, and to obtain final product.
embodiment 3: the preparation of granule
Each raw material is taken: Radix Bupleuri 10 parts, the Radix Angelicae Dahuricae 8 parts, Radix Angelicae Sinensis 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, 10 parts, Poria, Rhizoma Chuanxiong 10 parts, 8 parts, Rhizoma Gastrodiae, Radix Paeoniae Rubra 12 parts, the Radix Paeoniae Alba 12 parts, Flos Chrysanthemi 12 parts, Herba Menthae 5 parts, Radix Salviae Miltiorrhizae 18 parts, Fructus Viticis 15 parts according to following weight portion;
Add 4 times of water soakings 2 hours, decoct 2 times, 1.5 hours first times, second time 1 hour collecting decoction, filter, filtrate is concentrated into the thick paste that relative density is 1.08, low-temperature bake 10 hours, and get dry extract powder;
Get dried cream powder in proportion, select ethanol as binding agent, select starch as filler, granulate, granulate, pack, to obtain final product.
clinical verification:
Case: the present invention verifies migraineur 98 example, and all patients all meet migraine diagnostic criteria.After diagnosis is clear and definite, be divided into two groups, treatment group 50 example, male patient 24 example, female patient 26 example, age 28-57 year, course of disease 1-2 is not etc.; Matched group 48 example, male patient 24 example, female patient 24 example, age 30-61 year, course of disease 1-2 is not etc.
Therapeutic Method: peroral tablets: once a day, each 2, every sheet content of dispersion 0.5 gram, warm water takes; Oral capsule: once a day, each 3, every content of dispersion 0.4 gram, warm water takes; Granule for oral administration: twice daily, each 5 grams, warm water takes.
The course for the treatment of: one month be a course for the treatment of, treat 3 courses for the treatment of altogether.
The standard of curative effect evaluation:
Cure: headache disappears, Nausea and vomiting etc. disappear substantially.
Effective: headache disappears, Nausea and vomiting etc. significantly improve.
Effective: headache is even to be had, and Nausea and vomiting etc. improve substantially.
Invalid: headache syndromes does not improve, other simultaneous phenomenons only have be improved individually or change not remarkable.
Therapeutic outcome:
Treatment group: totally 50 examples, cures 45 examples, accounts for 90.0%; Effective 4 examples, account for 8.0%; Invalid 1 example, accounts for 2.0%; Total effective rate is 98.0%.
Matched group: totally 48 examples, cures 40 examples, accounts for 83.3%; Effective 4 examples, account for 8.4%; Invalid 4 examples, account for 8.3%; Total effective rate is 91.7%.
Result shows, and treatment group compares with matched group, difference significance, and particularly treatment group cure rate is far above matched group cure rate, illustrates that the therapeutic effect for the treatment of group is obviously better than matched group.
Claims (2)
1. treat a migrainous Chinese medicine composition, it is characterized in that being made up of the crude drug of following weight portion:
Radix Bupleuri 10 parts, the Radix Angelicae Dahuricae 8 parts, Radix Angelicae Sinensis 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, 10 parts, Poria, Rhizoma Chuanxiong 10 parts, 8 parts, Rhizoma Gastrodiae, Radix Paeoniae Rubra 12 parts, the Radix Paeoniae Alba 12 parts, Flos Chrysanthemi 12 parts, Herba Menthae 5 parts, Radix Salviae Miltiorrhizae 18 parts, Fructus Viticis 15 parts.
2. one according to claim 1 treats migrainous Chinese medicine composition, it is characterized in that: above-mentioned composition is made tablet, capsule or granule according to method of Chinese medicinal.
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CN105943893A (en) * | 2016-07-01 | 2016-09-21 | 覃益祥 | Traditional Chinese medicine for treating headache caused by influenza |
CN107375638A (en) * | 2017-09-09 | 2017-11-24 | 范莹 | A kind of Chinese medicine of tcm internal medicine treatment antimigraine and preparation method thereof |
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