CN103599403A - Traditional Chinese medicine composition for treating migraine and preparation method thereof - Google Patents

Abstract

The invention belongs to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating migraine and a preparation method thereof. The traditional Chinese medicine composition is composed for the following bulk drugs: radix bupleuri, angelica dahurica, Chinese angelica, atractylodes macrocephala, poria cocos, ligusticum chuanxiong, rhizoma gastrodiae, radix paeoniae rubra, radix paeoniae alba, chrysanthemum, mint, salvia miltiorrhiza and fructus viticis. The traditional Chinese medicine composition is prepared into tablets, capsules or granula according to a traditional Chinese medicine preparation method. The traditional Chinese medicine composition is reasonable in prescription, substantial in curative effect, none in side effect and high in safety.

Description

A kind of migrainous Chinese medicine composition and preparation method thereof for the treatment of

Technical field

The invention belongs to the field of Chinese medicines, be specifically related to a kind of migrainous Chinese medicine composition and preparation method thereof for the treatment of.

Background technology

Migraine is clinical modal primary headache type; clinical to take the headache of ictal middle severe, the sample of beating be main manifestations, and headache mostly is inclined to one side side, generally continues 4～72 hours; can be with feeling sick, vomitting; light, sound stimulate or daily routines all can increase the weight of headache, and quiet environment, rest can be alleviated headache, but the migrainous cause of disease is more complicated; performance also presents variation; mostly the medicine for the treatment of is relief of symptoms clinically at present, plays certain analgesic effect, cures the symptoms, not the disease.

Summary of the invention

The object of the invention is in order to make up the deficiencies in the prior art, a kind of migrainous Chinese medicine composition for the treatment of reasonable, that index is effected a permanent cure again of writing out a prescription is provided.

The migrainous medicine for the treatment of of the present invention, is comprised of the crude drug of following weight proportion:

Radix Bupleuri 8-15 part, Radix Angelicae Dahuricae 5-10 part, Radix Angelicae Sinensis 8-15 part, Rhizoma Atractylodis Macrocephalae 8-15 part, Poria 8-15 part, Rhizoma Chuanxiong 8-15 part, Rhizoma Gastrodiae 5-10 part, Radix Paeoniae Rubra 10-15 part, Radix Paeoniae Alba 10-15 part, Flos Chrysanthemi 10-15 part, Herba Menthae 3-8 part, Radix Salviae Miltiorrhizae 15-20 part, Fructus Viticis 10-20 part.

Its preferred each crude drug weight ratio is:

10 parts of Radix Bupleuri, 8 parts of the Radixs Angelicae Dahuricae, 10 parts of Radix Angelicae Sinensis, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts, Poria, 10 parts of Rhizoma Chuanxiong, 8 parts, Rhizoma Gastrodiae, 12 parts of Radix Paeoniae Rubra, 12 parts of the Radix Paeoniae Albas, 12 parts of Flos Chrysanthemis, 5 parts of Herba Menthaes, 18 parts of Radix Salviae Miltiorrhizaes, 15 parts of Fructus Viticises.

Above-mentioned Chinese medicine composition of the present invention adds prepares the required adjuvant of preparation, can be prepared into tablet, capsule or granule.

Usage and dosage: dosage of the present invention depends on concrete dosage form, simultaneously should be according to factors such as patient age, body weight and health status.As guidance: for oral administration, tablet: once a day, and each 2,0.5 gram of every content of dispersion, warm water takes; Capsule: once a day, each 3,0.4 gram of every content of dispersion, warm water takes; Granule: every day twice, each 5 grams, warm water takes.

In the present invention, the pharmacological action of each crude drug is as follows:

Radix Bupleuri: another name: ground is smoked, eggplant grass, HERBA BUPLEURI, RADIX BUPLEURI SCORZONERIFOLII, black Radix Bupleuri.Hardship, is slightly cold.Return liver, gallbladder meridian.Reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.

The Radix Angelicae Dahuricae: another name: Qi Baizhi, Yu Baizhi, the celery of galloping along on horseback, the meeting Radix Angelicae Dahuricae, fragrant Radix Angelicae Dahuricae (Radix Heraclei Scabridi).Pungent, temperature.Return stomach, large intestine, lung meridian.Loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.For headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.

Radix Angelicae Sinensis: another name: dry returning.Sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.

The Rhizoma Atractylodis Macrocephalae: another name: what art, mountain Ji, yellor rocket, Rhizoma Atractylodis Macrocephalae.Bitter, sweet, temperature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, the loose stool of having loose bowels, frequent fetal movement.

Poria: sweet, light, flat.GUIXIN, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating, calms the nerves.Cure mainly edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.

Rhizoma Chuanxiong: another name: Ligusticum slnense.Pungent, temperature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea ， mass in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.

Rhizoma Gastrodiae: another name: the winter is numb, the spring is numb.Sweet, flat.Return Liver Channel.Suppressing the hyperactive liver to relieve the wind syndrome relieving convulsion.Be used for having a headache dizzy, numb limbs and tense tendons, infantile convulsion, epilepsy clonus, tetanus.

Radix Paeoniae Rubra: another name: wooden Radix Paeoniae, red Radix Paeoniae, Radix Paeoniae Rubra.Hardship, is slightly cold.Return Liver Channel.Clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, { note of the ancient Chinese } abdominal mass stomachache, injury from falling down, carbuncle skin infection.

The Radix Paeoniae Alba: another name: Radix Paeoniae Alba, golden Radix Paeoniae.Bitter, sour, be slightly cold.Return liver, spleen channel.Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Be used for having a headache dizzy, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.

Flos Chrysanthemi: another name: longevity visitor, Jin Ying, Huang Hua, Jin Rui.Sweet, bitter, be slightly cold.Return lung, Liver Channel.Loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.

Herba Menthae: another name: HERBA MENTHAE, water mint, core Adiantum monochlamys Eaton., luxuriant lotus dish, Herba Menthae Rotundifoliae.: pungent, cool.Return lung, Liver Channel.Dispelling wind-heat.Refresh oneself, rash.For anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, breast side of body feeling of distension and oppression.

Radix Salviae Miltiorrhizae: another name: Arisaema balansae Engl., Radix Salviae Miltiorrhizae, Radix Campylotropis Hirtella (Herba Myrsines Africanae), wooden Lac caprae seu ovis.Hardship, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.For menoxenia, amenorrhea dysmenorrhea, { note of the ancient Chinese } abdominal mass is gathered, breast ventral spine pain, and pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.

Fructus Viticis: another name: wild pepper reality, Fructus Vitics Simplicifoliae, Folium Populi Albae, calico chaste tree.Pungent, bitter, be slightly cold.Return bladder, liver, stomach warp.Dispelling wind and heat pathogens, the clear sharp head.For anemopyretic cold headache, gingivitis, the many tear of conjunctival congestion, poor vision, has a dizzy spell.

It is to be used for the treatment of migraine that the function of Chinese medicine composition of the present invention cures mainly, and Chinese medical discrimination belongs to caused by hepatic stagnation qi stagnation.Disease is seen an inclined to one side side headache, or left or right, is distending pain, dull pain or the pain of fighting, companion's nausea and vomiting, fullness and distention in the chest and hypochondrium, irritated irritability, constipation with dry stool, thin white fur of tongue, stringy pulse more.

The specific embodiment

Below in conjunction with embodiment, the invention will be further described, but following examples are not limitation of the present invention.

embodiment 1: the preparation of tablet

According to following weight portion, take each raw material: 10 parts of Radix Bupleuri, 8 parts of the Radixs Angelicae Dahuricae, 10 parts of Radix Angelicae Sinensis, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts, Poria, 10 parts of Rhizoma Chuanxiong, 8 parts, Rhizoma Gastrodiae, 12 parts of Radix Paeoniae Rubra, 12 parts of the Radix Paeoniae Albas, 12 parts of Flos Chrysanthemis, 5 parts of Herba Menthaes, 18 parts of Radix Salviae Miltiorrhizaes, 15 parts of Fructus Viticises;

Add 4 times of water soakings 2 hours, decoct 2 times, 1.5 hours for the first time, 1 hour for the second time collecting decoction, filtered, and it is 1.08 thick paste that filtrate is concentrated into relative density, low-temperature bake 10 hours, and powder gets dry extract;

Get in proportion dried cream powder, cross 80 mesh sieves, with 5% starch slurry, prepare soft material, 16 mesh sieves are granulated, and wet granular is dried 2 hours at 40 ℃, and 14 mesh sieve granulate, add Pulvis Talci mix homogeneously, and then compacting in flakes.

embodiment 2: the preparation of capsule

According to following weight portion, take each raw material: 10 parts of Radix Bupleuri, 8 parts of the Radixs Angelicae Dahuricae, 10 parts of Radix Angelicae Sinensis, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts, Poria, 10 parts of Rhizoma Chuanxiong, 8 parts, Rhizoma Gastrodiae, 12 parts of Radix Paeoniae Rubra, 12 parts of the Radix Paeoniae Albas, 12 parts of Flos Chrysanthemis, 5 parts of Herba Menthaes, 18 parts of Radix Salviae Miltiorrhizaes, 15 parts of Fructus Viticises;

Add 4 times of water soakings 2 hours, decoct 2 times, 1.5 hours for the first time, 1 hour for the second time collecting decoction, filtered, and it is 1.08 thick paste that filtrate is concentrated into relative density, low-temperature bake 10 hours, and powder gets dry extract;

Get in proportion dried cream powder, with appropriate amount of starch slurry soft material processed, granulate, dry, granulate, incapsulates, and obtains.

embodiment 3: the preparation of granule

According to following weight portion, take each raw material: 10 parts of Radix Bupleuri, 8 parts of the Radixs Angelicae Dahuricae, 10 parts of Radix Angelicae Sinensis, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts, Poria, 10 parts of Rhizoma Chuanxiong, 8 parts, Rhizoma Gastrodiae, 12 parts of Radix Paeoniae Rubra, 12 parts of the Radix Paeoniae Albas, 12 parts of Flos Chrysanthemis, 5 parts of Herba Menthaes, 18 parts of Radix Salviae Miltiorrhizaes, 15 parts of Fructus Viticises;

Add 4 times of water soakings 2 hours, decoct 2 times, 1.5 hours for the first time, 1 hour for the second time collecting decoction, filtered, and it is 1.08 thick paste that filtrate is concentrated into relative density, low-temperature bake 10 hours, and powder gets dry extract;

Get in proportion dried cream powder, select ethanol as binding agent, select starch as filler, granulate, granulate, pack, obtains.

clinical verification:

Case: the present invention verifies migraineur's 98 examples, and all patients all meet migraine diagnostic criteria.After diagnosis is clear and definite, be divided into two groups, treatment group 50 examples, male patient's 24 examples, female patient's 26 examples, age 28-57 year, course of disease 1-2 is not etc.; Matched group 48 examples, male patient's 24 examples, female patient's 24 examples, in age 30-61 year, course of disease 1-2 is not etc.

Therapeutic Method: peroral tablets: once a day, each 2,0.5 gram of every content of dispersion, warm water takes; Oral capsule: once a day, each 3,0.4 gram of every content of dispersion, warm water takes; Granule for oral administration: every day twice, each 5 grams, warm water takes.

The course for the treatment of: one month be a course for the treatment of, treat altogether 3 courses for the treatment of.

The standard of curative effect evaluation:

Cure: headache disappears, feel sick, vomiting etc. disappears substantially.

Effective: headache disappears, feel sick, vomiting etc. significantly improves.

Effective: headache is even to be had, and feel sick, vomiting etc. improves substantially.

Invalid: headache symptom is not improved, and other simultaneous phenomenons only have and are improved individually or change not remarkable.

Therapeutic outcome:

Treatment group: totally 50 examples, cure 45 examples, account for 90.0%; Effective 4 examples, account for 8.0%; Invalid 1 example, accounts for 2.0%; Total effective rate is 98.0%.

Matched group: totally 48 examples, cure 40 examples, account for 83.3%; Effective 4 examples, account for 8.4%; Invalid 4 examples, account for 8.3%; Total effective rate is 91.7%.

Result shows, treatment group and matched group comparison, and difference significance, particularly treatment group cure rate, far above matched group cure rate, illustrate that the therapeutic effect for the treatment of group is obviously better than matched group.

Claims (2)

1. treat a migrainous Chinese medicine composition, it is characterized in that being formed by the crude drug of following weight portion:

10 parts of Radix Bupleuri, 8 parts of the Radixs Angelicae Dahuricae, 10 parts of Radix Angelicae Sinensis, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts, Poria, 10 parts of Rhizoma Chuanxiong, 8 parts, Rhizoma Gastrodiae, 12 parts of Radix Paeoniae Rubra, 12 parts of the Radix Paeoniae Albas, 12 parts of Flos Chrysanthemis, 5 parts of Herba Menthaes, 18 parts of Radix Salviae Miltiorrhizaes, 15 parts of Fructus Viticises.

2. Chinese medicine composition according to claim 1, is characterized in that: above-mentioned composition can be prepared into tablet, capsule or granule according to method of Chinese medicinal.