CN104127578B - Traditional Chinese medicine composition for treating acute or chronic rhinitis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating acute or chronic rhinitis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating acute or chronic rhinitis and a preparation method thereof. According to the technical scheme, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 6-10 parts of flower bud of lily magnolia, 3-5 parts of asarum, 10-50 parts of fructus forsythia, 10-20 parts of astragalus membranaceus, 9-15 parts of ligusticum wallichii, 5-15 parts of radix angelicae, 3-5 parts of dandelion, 20-40 parts of Chinese parsnip root, 10-30 parts of sanguisorba officinalis, 1-10 parts of poria cocos, 5-15 parts of medlar and 10-15 parts of liquorice. The traditional Chinese medicine composition disclosed by the invention can be prepared into different clinical dosage forms, and has a good effect in treatment or prevention of the acute or chronic rhinitis.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of acute and chronic rhinitis and preparation method thereof.
Background technology
Rhinitis refers to the inflammation of nasal membrane and submucous tissue.Show as hyperemia or edema, patient often there will be nasal obstruction, and stream clear water tears, rhinocnesmus, throat is uncomfortable, the symptoms such as cough.The wash sample material of nasal secretions is called nasal mucus or nasal secretion, and its effect helps dust out, and antibacterial is to keep the health of pulmonary.Under normal circumstances, be drawn to throat after the nasal mucus of mixed cell and dust and finally enter gastric, because its secretory volume is little, generally can not attract much attention.When inflammation appears in intranasal, nasal cavity can secrete a large amount of nasal mucus, and can because of infection yellowing, can cough be caused when flowing through throat, can also flow out through prenaris when nasal mucus amount is very many.
Acute and chronic rhinitis is China's commonly encountered diseases and frequently-occurring disease, and according to the literature, cacorhinia incidence rate fluctuation in various places is between 10.7-44.5%, especially in southern various places, have a humid climate, sickness rate is very high, and wherein 76% is occur in less than 30 years old, 6.4% is had between 40-50 year, within 50 years old, only have 1% or 2%, this course of disease is long, easily repeatedly later, Chang Yin, with symptoms such as headache, dizziness, hypomnesis, brings adverse effect to patient.
The sickness rate of rhinitis is in obviously increasing trend, and its sickness rate is 10 ~ 20% according to statistics, in recent years the sickness rate of rhinitis especially with annual 3 ~ 5% speed increment.Medical circle analysis and research result display: the upgrading of environmental pollution and the decline of air quality are the immediate causes causing rhinitis sickness rate to increase.Be suspended in the toxic gas such as motor vehicle exhaust emission thing, incineration of garbage thing, industrial production waste gas thing in the environment that we depend on for existence, and each bacterioid, dust etc., all the time all enter in nasal cavity in the breathing with people, once have an opportunity, these nuisances will grow in nasal cavity gathering, cause inflammation.People must breathe, and one breathes, and virus, antibacterial, anaphylactogen will enter with breathing, without any under the safeguard procedures protection of correspondence, must cause rhinitis, even can recurrent exerbation.
The Therapeutic Method of rhinitis has naturopathy, Drug therapy, operative treatment etc., and adopt simple physical or Drug therapy, DeGrain, treatment cycle is long, easily recurs; And adopting operative treatment, it costly has the risk producing postoperative sequela.Chinese medicine rhinitis curative effect is reliable, and toxic and side effects is little, has broad prospects.
Summary of the invention
In order to overcome prior art deficiency, the invention provides a kind of Chinese medicine composition for the treatment of acute and chronic rhinitis, this Chinese medicine composition good effect, side effect is little, and it is obtained by the raw material of following weight portion: Flos Magnoliae 6-10 part, Herba Asari 3-5 part, Fructus Forsythiae 10-50 part, Radix Astragali 10-20 part, Rhizoma Chuanxiong 9-15 part, Radix Angelicae Dahuricae 5-15 part, Herba Taraxaci 3-5 part, Radix Saposhnikoviae 20-40 part, Radix Sanguisorbae 10-30 part, Poria 1-10 part, Fructus Lycii 5-15 part, Radix Glycyrrhizae 10-15 part.
In Chinese medicine composition of the present invention, described Flos Magnoliae, nature and flavor: warm in nature, acrid in the mouth.Function cures mainly: dispersing wind and cold, clearing the nasal passage.For headche due to wind-cold, nasal obstruction, nasal sinusitis, turbid nasal discharge.
Herba Asari, meridian distribution of property and flavor, pungent, temperature.Return lung, kidney channel; Function, dispels the wind, dispersing cold for relieving pain, warming the lung to resolve fluid-retention, a surname's clearing the nasal passage; Cure mainly, anemofrigid cold, nasal obstruction headache, anemofrigid-damp arthralgia, QI rising in reverse order abundant expectoration is breathed with cough and is had a toothache.
Fructus Forsythiae, nature and flavor are bitter, are slightly cold.Gui Jing returns lung, the heart, small intestine meridian.Function cures mainly, heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warmly join the army, high hot excessive thirst, coma sends out speckle, pyretic stranguria urine retention.
The Radix Astragali, sweet, temperature.Return lung, spleen channel.Function cures mainly, invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
The pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keep, can go loose, and the up mountain peak that reaches is pushed up; Enter blood system again, descendingly reach the sea of blood.Blood circulation promoting and blood stasis dispelling effect is extensive, the suitable various disease of stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia.It is gas medicine in blood that former times people calls Rhizoma Chuanxiong, the functions such as pungent loose, the resolving depression of its residence of dangerous speech, sensible, pain relieving.The pungent temperature rise of this product is fallen apart, and all hyperactivity of YANG due to deficiency of YIN and excessive rising of liver-YANG person should not apply; Menorrhagia, anemia of pregnant woman also avoid use.
The Radix Angelicae Dahuricae, warm in nature, acrid in the mouth is micro-sweet, has expelling wind and removing dampness; Logical surreptitiously pain relieving; Effect of detumescence and apocenosis.Main headache due to common cold; Supraorbital bone pain; Toothache; Nasal obstruction; Nasal sinusitis; Domination of damp pathogen chronic diarrhea; Women leucorrhea; Ulcer sores; Venom.Clinical in headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.Also can be used for the cold expelling that induces sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis.Control headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp is suffered from abdominal pain, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Rhizoma Atractylodis have drying damp and strengthening spleen, expelling wind and cold, effect of improving eyesight, and for dampness taste, distension and fullness in the abdomen, cold-damp leucorrhea, damp-warm diseases and damp invasion of lower energizer, foot swelling and pain in knee, flaccidity are soft unable.Control dampness taste, and see the thick disease such as turbid of distension and fullness in the abdomen, inappetence, fatigue and weakness, white and greasy fur, the normal and compatibility such as Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae is applied.
Herba Taraxaci, nature and flavor with return through: bitter, sweet, cold.Return liver, stomach warp.Function with cure mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Radix Saposhnikoviae, acrid, sweet, warm.Return bladder, liver, spleen channel.Function cures mainly, inducing diaphoresis to dispel wind, and victory is wet, relieving convulsion.For headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus.
Radix Sanguisorbae, bitter, sour, puckery, be slightly cold.Function cures mainly, cooling blood for hemostasis, removing toxic substances sore.For having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, burn due to hot liquid or fire, carbuncle sore tumefacting virus.
Poria, is commonly called as Poria, Song Ling, Poria, and for colonizing in the fungi plant on pinaster root, shape is as Rhizoma Dioscoreae esculentae, and crust pitchy, the inside is white or pink.Ancients claim Poria to be " when four god medicine ", because its effect widely, regardless of the four seasons, by it and various compatibility of drugs, no matter cold, temperature, wind, wet all diseases, can play its unique effects.Poria sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.
Fructus Lycii (formal name used at school: Lycium chinense) is the multi-branched shrub plant of Solanaceae Lycium, and high 0.5-1 rice, can reach more than 2 meters during cultivation.All there is distribution both at home and abroad.Fructus Lycii whole body is precious, and bright Li Shizhen (1518-1593 A.D.) Compendium of Material Medica is recorded: " spring adopts Folium Lycii, name sky essence grass; Summer picks flowers, name Sempervivum tectorum; Qiu Caizi, name Fructus Lycii; Dong Caigen, name Cortex Lycii ".Fructus Lycii tender leaf also known as Fructus Lycii head, edible or make Fructus Lycii tea.Modern study, Fructus Lycii has reduction blood glucose, lipotropy, and can antiatherogenic effect.
Radix Glycyrrhizae, nature and flavor are sweet, flat.Gui Jing enters spleen, stomach, lung meridian.Function cures mainly: with middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.Process use, control weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, infantile convulsion; Raw use, controls laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.
Chinese medicine composition of the present invention is with clearing away damp-heat on Chinese medicinal components is selected, and clearing the nasal passage, dispersing liver-energy, strengthening the spleen and stomach is main standard, has significant anti-inflammatory activity effect after Chinese medicine composition combination of the present invention simultaneously.The parts by weight of the present invention to above-mentioned all taste Chinese medicine carry out preferably, preferred condition be after drug matching uses medicine to the enhancing of acute and chronic rhinitis therapeutic effect.As a preferred embodiment of the present invention, Chinese medicine composition of the present invention is obtained by the raw material of following weight portion: Flos Magnoliae 8 parts, Herba Asari 4 parts, Fructus Forsythiae 30 parts, the Radix Astragali 15 parts, Rhizoma Chuanxiong 12 parts, the Radix Angelicae Dahuricae 9 parts, Herba Taraxaci 4 parts, Radix Saposhnikoviae 30 parts, Radix Sanguisorbae 20 parts, 6 parts, Poria, Fructus Lycii 9 parts, 12 parts, Radix Glycyrrhizae.
In order to express Chinese medicine composition of the present invention better, Chinese medicine composition of the present invention can be prepared into dosage form conventional clinically.It mainly comprises following step: Flos Magnoliae, Herba Asari, Rhizoma Chuanxiong, Poria add ethanol extraction secondary, each 1-2 hour, merge extractive liquid, filters, filtrate recycling ethanol, concentrating under reduced pressure; The 5-10 times amount soak by water secondary of Fructus Forsythiae, the Radix Astragali, the Radix Angelicae Dahuricae, Herba Taraxaci, Radix Saposhnikoviae, Radix Sanguisorbae, Fructus Lycii, Radix Glycyrrhizae gross weight, first time decocts 2-3 hour, and second time decocts 1-2 hour, collecting decoction, filter, filtrate reduced in volume, adds ethanol,-5 ~-2 DEG C of cold preservation 12-48 hour, filter, filtrate recycling ethanol, concentrated, merge above two kinds of thick pastes, add starch, mixing, dry, pulverize into fine powder, mixing, sieves, prepares conventional Chinese medicine pharmaceutical dosage form clinically.
Conventional Chinese medicine pharmaceutical dosage form such as clinically, any one in the middle of pill, tablet, granule, oral liquid, capsule, unguentum, Emulsion, masticatory, injection.Preferably, Chinese medicine composition of the present invention conveniently preparation technology be prepared into granule, tablet or capsule.
Drug excipient is added in described pharmaceutical dosage form.Preferably, described excipient is one or more in the middle of flavoring agent, dispersant, binding agent, thickening agent, lubricant, diluent.
The present invention also asks to protect the purposes of above-mentioned Chinese medicine composition in preparation treatment acute and chronic rhinitis medicine.Pharmaceutical composition of the present invention, when treating acute and chronic rhinitis, demonstrates significant anti-inflammatory activity.Test examples 8 of the present invention shows, the heavy dose of group of the present invention 2,3,4 and 5 hours points after causing inflammation have obvious inhibitory action (P<0.01), middle dosage group 2 hours points after causing inflammation have obvious inhibitory action (P<0.01), middle dosage group has inhibitory action (P<0.05) at 3,4 hours points, and it exists significant dose-effect relationship to the reduction effect of swelling.Under same experiment condition, positive control drug 2,3,4 and 5 hours points after causing inflammation have obvious inhibitory action (P<0.01), but effect is not as good as the heavy dose of group of the present invention.
The present invention be inventor through repeatedly studying, progressively improve, last successful a kind of curative effect treats the medicine of acute and chronic rhinitis preferably, can verify the therapeutic effect of medicine of the present invention to acute and chronic rhinitis by 700 routine clinical cases.Wherein, clinical cure: symptom all disappears, does not recur for continuous more than 1 year; Effective: symptom all disappears, recur in 1 year, but symptom obviously alleviates; Effective: symptom is clearly better, recur again in half a year; Invalid: symptom is not improved or namely drug withdrawal recurs.
The present invention has carried out clinical observation to the chronic rhinitis patient that 500 examples take this medicine, achieves good curative effect, and in 500 routine patients, after medication March, cure 425 examples, cure rate accounts for 85%; Take a turn for the better 40 examples, and obvious effective rate accounts for 8%; Effective 26 examples, effective percentage accounts for 5.2%; Total effective rate 98.2%, no effect 9, inefficiency accounts for 1.8%.
The present invention has carried out clinical observation to the acute rhinitis patient that 200 examples take this medicine, achieves good curative effect equally, and in 200 routine patients, medication is after 4 days, and cure 160 examples, cure rate accounts for 80%; Take a turn for the better 12 examples, and obvious effective rate accounts for 6%; Effective 10 examples, effective percentage accounts for 5%; Total effective rate 91%, invalid 18 examples, inefficiency accounts for 9%.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1
Prescription: Flos Magnoliae 8 parts, Herba Asari 4 parts, Fructus Forsythiae 30 parts, the Radix Astragali 15 parts, Rhizoma Chuanxiong 12 parts, the Radix Angelicae Dahuricae 9 parts, Herba Taraxaci 4 parts, Radix Saposhnikoviae 30 parts, Radix Sanguisorbae 20 parts, 6 parts, Poria, Fructus Lycii 9 parts, 12 parts, Radix Glycyrrhizae;
Preparation method: Flos Magnoliae, Herba Asari, Rhizoma Chuanxiong, Poria add ethanol extraction secondary, each 1.5 hours, merge extractive liquid, filtered, filtrate recycling ethanol, concentrating under reduced pressure; 8 times amount soak by water secondaries of Fructus Forsythiae, the Radix Astragali, the Radix Angelicae Dahuricae, Herba Taraxaci, Radix Saposhnikoviae, Radix Sanguisorbae, Fructus Lycii, Radix Glycyrrhizae gross weight, first time decocts 2.5 hours, and second time decocts 1.5 hours, collecting decoction, filter, filtrate reduced in volume, adds ethanol,-3 DEG C of cold preservation 24 hours, filters, filtrate recycling ethanol, concentrated, merge above two kinds of thick pastes, add starch, mixing, dry, pulverize into fine powder, mixing, sieves, makes tablet by conventional formulation method.
Embodiment 2
Prescription: Flos Magnoliae 8 parts, Herba Asari 4 parts, Fructus Forsythiae 30 parts, the Radix Astragali 15 parts, Rhizoma Chuanxiong 12 parts, the Radix Angelicae Dahuricae 9 parts, Herba Taraxaci 4 parts, Radix Saposhnikoviae 30 parts, Radix Sanguisorbae 20 parts, 6 parts, Poria, Fructus Lycii 9 parts, 12 parts, Radix Glycyrrhizae;
Preparation method: Flos Magnoliae, Herba Asari, Rhizoma Chuanxiong, Poria add ethanol extraction secondary, each 1.5 hours, merge extractive liquid, filtered, filtrate recycling ethanol, concentrating under reduced pressure; 8 times amount soak by water secondaries of Fructus Forsythiae, the Radix Astragali, the Radix Angelicae Dahuricae, Herba Taraxaci, Radix Saposhnikoviae, Radix Sanguisorbae, Fructus Lycii, Radix Glycyrrhizae gross weight, first time decocts 2.5 hours, and second time decocts 1.5 hours, collecting decoction, filter, filtrate reduced in volume, adds ethanol,-3 DEG C of cold preservation 24 hours, filters, filtrate recycling ethanol, concentrated, merge above two kinds of thick pastes, add starch, mixing, dry, pulverize into fine powder, mixing, sieves, makes capsule by conventional formulation method.
Embodiment 3
Prescription: Flos Magnoliae 6 parts, Herba Asari 3 parts, Fructus Forsythiae 10 parts, the Radix Astragali 10 parts, Rhizoma Chuanxiong 9 parts, the Radix Angelicae Dahuricae 5 parts, Herba Taraxaci 3 parts, Radix Saposhnikoviae 20 parts, Radix Sanguisorbae 10 parts, 1 part, Poria, Fructus Lycii 5 parts, 10 parts, Radix Glycyrrhizae;
Preparation method: Flos Magnoliae, Herba Asari, Rhizoma Chuanxiong, Poria add ethanol extraction secondary, each 2 hours, merge extractive liquid, filtered, filtrate recycling ethanol, concentrating under reduced pressure; 10 times amount soak by water secondaries of Fructus Forsythiae, the Radix Astragali, the Radix Angelicae Dahuricae, Herba Taraxaci, Radix Saposhnikoviae, Radix Sanguisorbae, Fructus Lycii, Radix Glycyrrhizae gross weight, first time decocts 3 hours, and second time decocts 2 hours, collecting decoction, filter, filtrate reduced in volume, adds ethanol,-5 DEG C of cold preservation 48 hours, filters, filtrate recycling ethanol, concentrated, merge above two kinds of thick pastes, add starch, mixing, dry, pulverize into fine powder, mixing, sieves, makes capsule by conventional formulation method.
Embodiment 4
Prescription: Flos Magnoliae 10 parts, Herba Asari 5 parts, Fructus Forsythiae 50 parts, the Radix Astragali 20 parts, Rhizoma Chuanxiong 15 parts, the Radix Angelicae Dahuricae 15 parts, Herba Taraxaci 5 parts, Radix Saposhnikoviae 40 parts, Radix Sanguisorbae 30 parts, 10 parts, Poria, Fructus Lycii 15 parts, 15 parts, Radix Glycyrrhizae;
Preparation method: Flos Magnoliae, Herba Asari, Rhizoma Chuanxiong, Poria add ethanol extraction secondary, each 1 hour, merge extractive liquid, filtered, filtrate recycling ethanol, concentrating under reduced pressure; 5 times amount soak by water secondaries of Fructus Forsythiae, the Radix Astragali, the Radix Angelicae Dahuricae, Herba Taraxaci, Radix Saposhnikoviae, Radix Sanguisorbae, Fructus Lycii, Radix Glycyrrhizae gross weight, first time decocts 2 hours, and second time decocts 1 hour, collecting decoction, filter, filtrate reduced in volume, adds ethanol,-2 DEG C of cold preservation 12 hours, filters, filtrate recycling ethanol, concentrated, merge above two kinds of thick pastes, add starch, mixing, dry, pulverize into fine powder, mixing, sieves, makes capsule by conventional formulation method.
Embodiment 5
Prescription: Flos Magnoliae 6 parts, Herba Asari 5 parts, Fructus Forsythiae 10 parts, the Radix Astragali 20 parts, Rhizoma Chuanxiong 9 parts, the Radix Angelicae Dahuricae 15 parts, Herba Taraxaci 3 parts, Radix Saposhnikoviae 40 parts, Radix Sanguisorbae 10 parts, 10 parts, Poria, Fructus Lycii 5 parts, 15 parts, Radix Glycyrrhizae;
Preparation method: Flos Magnoliae, Herba Asari, Rhizoma Chuanxiong, Poria add ethanol extraction secondary, each 2 hours, merge extractive liquid, filtered, filtrate recycling ethanol, concentrating under reduced pressure; 10 times amount soak by water secondaries of Fructus Forsythiae, the Radix Astragali, the Radix Angelicae Dahuricae, Herba Taraxaci, Radix Saposhnikoviae, Radix Sanguisorbae, Fructus Lycii, Radix Glycyrrhizae gross weight, first time decocts 2 hours, and second time decocts 1 hour, collecting decoction, filter, filtrate reduced in volume, adds ethanol,-5 DEG C of cold preservation 12 hours, filters, filtrate recycling ethanol, concentrated, merge above two kinds of thick pastes, add starch, mixing, dry, pulverize into fine powder, mixing, sieves, makes capsule by conventional formulation method.
Embodiment 6
Prescription: Flos Magnoliae 10 parts, Herba Asari 3 parts, Fructus Forsythiae 50 parts, the Radix Astragali 10 parts, Rhizoma Chuanxiong 15 parts, the Radix Angelicae Dahuricae 5 parts, Herba Taraxaci 5 parts, Radix Saposhnikoviae 20 parts, Radix Sanguisorbae 30 parts, 1 part, Poria, Fructus Lycii 15 parts, 10 parts, Radix Glycyrrhizae;
Preparation method: Flos Magnoliae, Herba Asari, Rhizoma Chuanxiong, Poria add ethanol extraction secondary, each 1 hour, merge extractive liquid, filtered, filtrate recycling ethanol, concentrating under reduced pressure; 5 times amount soak by water secondaries of Fructus Forsythiae, the Radix Astragali, the Radix Angelicae Dahuricae, Herba Taraxaci, Radix Saposhnikoviae, Radix Sanguisorbae, Fructus Lycii, Radix Glycyrrhizae gross weight, first time decocts 3 hours, and second time decocts 2 hours, collecting decoction, filter, filtrate reduced in volume, adds ethanol,-2 DEG C of cold preservation 48 hours, filters, filtrate recycling ethanol, concentrated, merge above two kinds of thick pastes, add starch, mixing, dry, pulverize into fine powder, mixing, sieves, makes capsule by conventional formulation method.
Embodiment 7
Prescription: Flos Magnoliae 8 parts, Herba Asari 4 parts, Fructus Forsythiae 30 parts, the Radix Astragali 15 parts, Rhizoma Chuanxiong 12 parts, the Radix Angelicae Dahuricae 9 parts, Herba Taraxaci 4 parts, Radix Saposhnikoviae 30 parts, Radix Sanguisorbae 20 parts, 6 parts, Poria, Fructus Lycii 9 parts, 12 parts, Radix Glycyrrhizae;
Preparation method: Flos Magnoliae, Herba Asari, Rhizoma Chuanxiong, Poria add ethanol extraction secondary, each 1.5 hours, merge extractive liquid, filtered, filtrate recycling ethanol, concentrating under reduced pressure; 8 times amount soak by water secondaries of Fructus Forsythiae, the Radix Astragali, the Radix Angelicae Dahuricae, Herba Taraxaci, Radix Saposhnikoviae, Radix Sanguisorbae, Fructus Lycii, Radix Glycyrrhizae gross weight, first time decocts 2.5 hours, and second time decocts 1.5 hours, collecting decoction, filter, filtrate reduced in volume, adds ethanol,-3 DEG C of cold preservation 24 hours, filters, filtrate recycling ethanol, concentrated, merge above two kinds of thick pastes, add starch, mixing, dry, pulverize into fine powder, mixing, sieves, makes granule by conventional formulation method.
Embodiment 8 Chinese medicine composition xylol of the present invention causes the impact of mice ear
Get healthy Wistar rat 60, body weight 170-180g, male and female half and half, be divided into 5 groups at random, often organize 12, be respectively heavy dose of group (3.2g/kg), the middle dosage group (1.6g/kg) of the embodiment of the present invention 2 preparation, small dose group (0.8g/kg), positive control Biyan Ning capsule group (0.35g/kg) (Quanzhou, Fujian Province Luo Shangshan pharmaceutical factory) and distilled water matched group.Every day gastric infusion once, for three days on end, the isopyknic distilled water of blank group gavage.After last administration 1 hour, the right back sufficient plantar subcutaneous injection 1% carrageenin 0.05ml of every Mus causes inflammation, cause scorching before and cause scorching after within 1,2,3,4,5 hour, measure the sufficient sole of the foot volume (capillary tube measurement by magnification method) of fixed position respectively, calculating causes the sufficient volume difference in scorching front and back as swelling, in table 1.
The impact (X ± SD, n=10) of rat toes swelling caused by table 1 on Carrageenan
Note: compare with distilled water matched group, * p<0.05, * * p<0.01.
Result shows, the heavy dose of group of the present invention 2,3,4 and 5 hours points after causing inflammation have obvious inhibitory action (P<0.01), middle dosage group 2 hours points after causing inflammation have obvious inhibitory action (P<0.01), middle dosage group has inhibitory action (P<0.05) at 3,4 hours points, and it exists significant dose-effect relationship to the reduction effect of swelling.Under same experiment condition, positive control drug 2,3,4 and 5 hours points after causing inflammation have obvious inhibitory action (P<0.01), but effect is not as good as the heavy dose of group of the present invention.
Claims (5)
1. treat a Chinese medicine composition for acute and chronic rhinitis, it is characterized in that it is obtained by the raw material of following weight portion: Flos Magnoliae 8 parts, Herba Asari 4 parts, Fructus Forsythiae 30 parts, the Radix Astragali 15 parts, Rhizoma Chuanxiong 12 parts, the Radix Angelicae Dahuricae 9 parts, Herba Taraxaci 4 parts, Radix Saposhnikoviae 30 parts, Radix Sanguisorbae 20 parts, 6 parts, Poria, Fructus Lycii 9 parts, 12 parts, Radix Glycyrrhizae.
2. a preparation method for Chinese medicine composition as claimed in claim 1, is characterized in that it comprises the following steps: Flos Magnoliae, Herba Asari, Rhizoma Chuanxiong, Poria add ethanol extraction secondary, each 1-2 hour, merge extractive liquid, filters, filtrate recycling ethanol, concentrating under reduced pressure; The 5-10 times amount soak by water secondary of Fructus Forsythiae, the Radix Astragali, the Radix Angelicae Dahuricae, Herba Taraxaci, Radix Saposhnikoviae, Radix Sanguisorbae, Fructus Lycii, Radix Glycyrrhizae gross weight, first time decocts 2-3 hour, and second time decocts 1-2 hour, collecting decoction, filter, filtrate reduced in volume, adds ethanol,-5 ~-2 DEG C of cold preservation 12-48 hour, filter, filtrate recycling ethanol, concentrated, merge above two kinds of thick pastes, add starch, mixing, dry, pulverize into fine powder, mixing, sieves, prepares conventional Chinese medicine pharmaceutical dosage form clinically.
3. according to the preparation method in claim 2, it is characterized in that, described pharmaceutical dosage form is any one in the middle of pill, tablet, granule, oral liquid, capsule, unguentum, Emulsion, masticatory, injection.
4., according to the said preparation method of claim 3, it is characterized in that adding drug excipient in described pharmaceutical dosage form.
5., according to the said preparation method of claim 4, it is characterized in that described excipient is one or more in the middle of flavoring agent, dispersant, binding agent, thickening agent, lubricant, diluent.
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| CN102462784A (en) * | 2010-11-10 | 2012-05-23 | 罗朝雯 | Chinese herbal medicine prescription for treating rhinitis |
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