CN104127751A - Traditional Chinese medicine for treating chronic bronchitis caused by phlegm-dampness lung attacking and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine for treating chronic bronchitis caused by phlegm-dampness lung attacking and a preparation method thereof. The traditional Chinese medicine comprises the following raw herbal materials: rhizoma atractylodis, cortex magnoliae officinalis, pericarpium citri reticulatae, semen raphani, paederia scandens, pinellia ternate, rhizoma arisaematis, gleditsia sinensis, willowleaf swallowwort rhizome, platycodon grandiflorum, semen armeniacae amarae, flos farfarae, folium eriobotryae, ginkgo, radix physochlainae, momordica grosvenori, radix pseudostellariae, bighead atractylodes rhizome, Chinese yam, acanthopanax, sea-buckthorn, poria cocos, semen coicis, swamp cudweed herb, parmelia tinctourium, japanese inula herb, caulis bambusae in taeniam, Indian rorippa herb, ligularia sibirica, indigo naturalis, vetchleaf sophora root and liquorice. The traditional Chinese medicine has the beneficial effects of drying dampness and resolving phlegm, and regulating the flow of vital energy and relieving a cough, is mainly used for treating the chronic bronchitis caused by phlegm-dampness lung attacking, is used for carrying out syndrome differentiation and treatment on the basis of the whole view by adjusting the circulation of vital energy and blood and enhancing the immunity of the organism according to the traditional Chinese medicine theory, is safe and effective, and is short in treatment course, the recovery rate can be obviously increased, the recurrence rate is lowered, and the living quality of patients is significantly improved.

Description

A kind of Chinese medicine and preparation method for the treatment of phlegm-damp criminal pulmonary type chronic bronchitis

Technical field

The present invention relates to pharmaceutical technology, particularly a kind of Chinese medicine and preparation method for the treatment of phlegm-damp criminal pulmonary type chronic bronchitis.

 

Background technology

Chronic bronchitis (chronic bronchitis) is the chronic nonspecific inflammation of trachea, bronchial mucosa and surrounding tissue thereof.Take clinically cough, expectoration or with asthma etc. repeatedly outbreak be cardinal symptom, continue 3 months every year, continuous more than 2 years.Early symptom is slight, and more than winter attack, spring and summer is alleviated.Increase the weight of because of inflammation late period, and symptom can exist throughout the year.Its Pathologic Characteristics is bronchus body of gland hypertrophy and mucosa secretion increasing.The state of an illness is slowly carrying out property progress, Chang Bingfa obstructive emphysema, and often there is pulmonary hypertension in severe patient, even pulmonary heart disease.

Etiology and pathology

Normal condition lower respiratory tract has perfect defense function, to the air sucking, can bring into play filtration, add the effect of gentle humidifying; The ciliary movement of air flue mucous membrane surface and coughre flex etc., can remove foreign body and pathogenic microorganism in air flue whereby.Therefore, lower respiratory tract generally can keep purification state.Whole body or respiratory tract local defense and immunocyte decline, especially old people, very easily suffer from chronic bronchitis, and repeatedly outbreak and do not heal.

1. smoking is the principal element of primary disease morbidity, in medicated cigarette, containing chemical substances such as tar, nicotine and hydrocyanic acids, can damage human airway epithelial cells, ciliary movement is gone down and macrophage phagocytic function reduction, causes Airway clearance function reduction.And sensor under can irritates nucous membrane, make parasympathetic functions hyperfunction, cause that bronchial smooth muscle shrinks, cause airway resistance to increase, and glandular secretion increase, goblet cell hyperplasia, bronchial mucosa congestion and edema, mucus gather, and easily bring out infection.In addition, smoke from cigarette also can make the generation of toxicity oxygen-derived free radicals increase, and induction neutrophilic granulocyte discharges protease, suppresses protease inhibitor system, destroys pulmonary elastic fibers, brings out emophysematous generation.Research shows, the prevalence of smoker's chronic bronchitis is high 2～8 times compared with non-smoker, and the length of smoking is longer, and cigarette amount is larger, and prevalence is also higher.

2. atmospheric pollution harmful gas all has and stimulates and cytotoxicity air flue mucosal epithelium as sulfur dioxide, nitrogen dioxide, chlorine and ozone etc.It was reported that, when airborne flue dust or sulfur dioxide surpass 1000 μ g/m3, acute episode of chronic bronchitis just significantly increases.Other dust, as silicon dioxide, coal dust, sugarcane dirt, flocking etc. also can stimulate damage bronchial mucosa, make lung remove function sustain damage, for antibacterial infects, create conditions.

3. infective agent is one of key factor of chronic bronchitis generation and development.Virus, mycoplasma and antibacterial infect for the main cause of primary disease acute attack.Viral infection be take influenza virus, rhinovirus, adenovirus and respiratory syncytial virus as common.Antibacterial infects take streptococcus pneumoniae, hemophilus influenza, mucositis mora bacterium and staphylococcus as common.Antibacterial infects to be often secondary on virus or the impaired basis of mycoplasma infection air flue mucosa and occurs.

4. irritated factor chronic asthmatic bronchitis patient, there are allergies more, the tuerculoderma positive rate that multiple anaphylactogen is excited is also higher, in sputum, in eosinophilic granulocyte's quantity and histamine content and blood, IgE has the trend increasing, the rheumatoid factor positive and t lymphocyte subset group abnormal distribution etc. in some patients were serum, therefore think that spy answers matter (atopy) relevant with the generation of primary disease with immune factor, but also have, think that spy answers matter should belong to the pathogenic factors of asthma, in fact this type of patient should belong to the category of asthma or chronic bronchitis merging asthma.

Other: acute episode of chronic bronchitis is more winter, so meteorological factor should be considered as one of key factor of morbidity.Cold air can stimulate glandular secretion mucus to increase and ciliary movement weakens, and weakens the defense function of air flue.Also can cause bronchial muscular spasm by reflection, mucosa vasoconstriction, blood circulation obstacle, is conducive to secondary infection.The most patient of primary disease has the phenomenon of autonomic nervous function imbalance, and some patients were parasympathetic functions is hyperfunction, and airway reactivity calibration ordinary person increases.In addition, old people's hypoadrenocorticism, cellular immune function is impaired, and lysozyme activity reduces, Undernutrition, vitamin A, C deficiency etc. all can make air flue mucosa vascular permeability increase and epithelial repair hypofunction.Whether inherited genetic factors is relevant with chronic bronchitis morbidity, there is no so far conclusive evidence.

Clinical manifestation

1. how slow symptom onset is, and the course of disease is longer, and some patients were premorbid has the acute respiratory infection histories such as acute bronchitis, influenza or pneumonia, because protracted course of disease develops into primary disease.Cardinal symptom is chronic cough, expectoration and breathes hard or with panting.The symptom initial stage is lighter, and along with course advancement, because of recurrent respiratory tract infection, acute attack is more frequent, and symptom is also more serious, especially with winter for very.

(1) cough: initial stage daystart cough is heavier, and daytime is lighter, and night in late period is also obvious, often has apasm of coughing outbreak, and accompany expectoration before sleeping.This is because bronchial mucosa is congested, edema, due to secretions accumulates in bronchial lumen.Along with PD, cough is not healed all the year round.

(2) expectoration: especially many with daystart expectoration, sputum is generally white mucus or serosity spumescence, occasionally can be with blood.During this polyphyly nighttime sleep, coughre flex is blunt, and air flue intracavity sputum is piled up, daystart get up after because of position change cause stimulate expectoration therefore.When acute attack is infected with antibacterial, amount of expectoration increases, and sputum becomes sticky or purulence.

(3) breathe hard and pant: how not obvious the course of disease initial stage is, when course advancement merges obstructive emphysema, engendering different the breathing hard of light and heavy degree, with after activity more so.Chronic bronchitis merges the patient of asthma or so-called chronic asthmatic bronchitis, especially when acute attack, often occurs the symptom of panting, and often with wheezing sound.

2. sign is early stage many without any abnormal sign, or can hear and be dispersed in dry, moist rales in base of lung portion, and after coughing up of sputum, rale can disappear, and acute attack stage pulmonary rale can increase, and its quantity number is depending on the state of an illness.Audible and extensive wheezing sound accompany prolonged expiration when chronic bronchitis merges the patients acuity outbreak of asthma.Patients with terminal often has emophysematous sign because of Complicated with Pulmonary edema due to disorder of QI, consults obstructive emphysema part.

Clinical syndrome is divided into:

Phlegm-damp is violated drink type, phlegm-heat accumulated in the lung type, asthenia of pulmonosplenic qi type, YIN-deficiency type of the lung and kidney, yang deficiency of spleen and stomache in pulmonary type, exogenous cold.

Wherein phlegm-damp is violated pulmonary type: cough with copious phlegm, and Se Bai and gluing, chest distress, abdominal distension and anorexia, extremity are aching and tired, loose stool.White and greasy fur, stringy and rolling pulse or moisten slow.

Drink type in exogenous cold: cough and asthma, the white many foams of expectorant, coldness of the body and aversion to cold, general pain is heavy, and tastelessness and no thirst or xerostomia be wish drink not.White, slippery and moist fur, stringy and tense pulse.

Phlegm-heat accumulated in the lung type: coughing and wheezing, pharyngalgia, the yellow thickness of expectorant, fullness in the chest is rough, thirst and liking drink, dark coloured urine constipation.Red tongue, yellow and greasy fur, slippery and rapid pulse or big vast number.

Asthenia of pulmonosplenic qi type: cough ant phlegm, breathe hard, pant, aversion to wind spontaneous perspiration, poor appetite body is tired, loose stool, aqueous-grainy diarrhea.Pale tongue with thin fur is white, and floating and moderate pulse is unable.

YIN-deficiency type of the lung and kidney: take dry cough as main, the few or dry cough without phlegm of the amount of coughing up phlegm, expectorant is sticky to be led deadly, is difficult for bringing up mouth and nose dry pharynx, dysphoria with feverish sensation in the chest palms and soles, constipation with dry stool.The few tongue of red tongue, the few Tianjin of lingual surface, thready and rapid pulse.

Yang deficiency of spleen and stomache: do during cough, sputum is rare clearly, breathes heavily and breathes hard, moving more so, aversion to cold and cold limbs, lassitude.Enlarged tongue is large, white, slippery and moist fur, deep-thready pulse.

But, western medical treatment chronic bronchitis, the course for the treatment of is longer, widely applies for a long time antibiotic, bronchodilator, expectorant easily to produce drug resistance, and clinical efficacy is not satisfactory, and the state of an illness is outbreak repeatedly easily, has a strong impact on patient's quality of life etc.

Yet, Treating Chronic Bronchitis with Traditional Chinese Medicine, possess unique advantage and feature: utilize Traditional Chinese medical theory, on the basis of Overall View, by regulating qi-blood circulating, enhancing human body immunity power, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, according to the many target treatments of different diseases, expansion bronchus, strengthen the respiratory function of respiratory muscle, promote expectoration cough-relieving, relieving asthma, keep respiratory passage unblocked, the drug effect focus of going directly, safe and effective, the course for the treatment of is shorter, and be difficult for producing drug resistance, cost price is lower, convenient drug administration, patient is easy to accept, can obviously improve cure rate, reduce complication, reduce relapse rate, significantly improve patient's quality of life etc.

 

Summary of the invention

The technical problem to be solved in the present invention is to provide a kind of Chinese medicine and preparation method that phlegm-damp is violated lung chronic bronchitis for the treatment of, the present invention has drying dampness to eliminate phlegm, the regulate the flow of vital energy effect of cough-relieving, cure mainly phlegm-damp and violate pulmonary type chronic bronchitis, utilize Traditional Chinese medical theory, on the basis of Overall View, by regulating qi-blood circulating, enhancing human body immunity power, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, expansion bronchus, strengthen the respiratory function of respiratory muscle, promote expectoration cough-relieving, relieving asthma, keep respiratory passage unblocked, the drug effect focus of going directly, safe and effective, the course for the treatment of is shorter, and be difficult for producing drug resistance, cost price is lower, convenient drug administration, patient is easy to accept, can obviously improve cure rate, reduce complication, reduce relapse rate, significantly improve patient's quality of life.

In order to realize foregoing invention object, the invention provides a kind of Chinese medicine that phlegm-damp is violated pulmonary type chronic bronchitis for the treatment of, wherein, comprise following raw medicinal material: Rhizoma Atractylodis, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Semen Raphani, fevervine, the Rhizoma Pinelliae, Rhizoma Arisaematis, Fructus Gleditsia, Rhizoma Cynanchi Stauntonii, Radix Platycodonis, Semen Armeniacae Amarum, Flos Farfarae, Folium Eriobotryae, Semen Ginkgo, Radix Physochlainae, Fructus Momordicae, Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Fructus Hippophae, Poria, Semen Coicis, Herba Gnaphalii uliginosi, Parmelia saxatilis Ach., Herba Inulae, Caulis Bambusae In Taenia, Herba Rorippae, Radix Ligulariae Dentatae, Indigo Naturalis, Radix Sophorae Viciifoliae and Radix Glycyrrhizae.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Rhizoma Atractylodis 20-34 part, Cortex Magnoliae Officinalis 27-42 part, Pericarpium Citri Reticulatae 14-32 part, Semen Raphani 23-39 part, fevervine 14-30 part, Rhizoma Pinelliae 3-8 part, Rhizoma Arisaematis 4-9 part, Fructus Gleditsia 5-10 part, Rhizoma Cynanchi Stauntonii 17-35 part, Radix Platycodonis 22-36 part, Semen Armeniacae Amarum 5-11 part, Flos Farfarae 15-33 part, Folium Eriobotryae 10-25 part, Semen Ginkgo 4-10 part, Radix Physochlainae 3-9 part, Fructus Momordicae 18-31 part, Radix Pseudostellariae 11-27 part, Rhizoma Atractylodis Macrocephalae 16-37 part, Rhizoma Dioscoreae 15-27 part, Radix Et Caulis Acanthopanacis Senticosi 19-34 part, Fructus Hippophae 20-34 part, Poria 13-32 part, Semen Coicis 23-38 part, Herba Gnaphalii uliginosi 12-28 part, Parmelia saxatilis Ach. 12-27 part, Herba Inulae 13-30 part, Caulis Bambusae In Taenia 24-37 part, Herba Rorippae 19-33 part, Radix Ligulariae Dentatae 6-19 part, Indigo Naturalis 26-39 part, Radix Sophorae Viciifoliae 21-33 part and Radix Glycyrrhizae 27-42 part.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Rhizoma Atractylodis 21-32 part, Cortex Magnoliae Officinalis 27-40 part, Pericarpium Citri Reticulatae 16-30 part, Semen Raphani 25-35 part, fevervine 16-28 part, Rhizoma Pinelliae 3-6 part, Rhizoma Arisaematis 4-7 part, Fructus Gleditsia 5-8 part, Rhizoma Cynanchi Stauntonii 19-33 part, Radix Platycodonis 24-32 part, Semen Armeniacae Amarum 5-9 part, Flos Farfarae 17-31 part, Folium Eriobotryae 12-22 part, Semen Ginkgo 4-8 part, Radix Physochlainae 3-7 part, Fructus Momordicae 18-28 part, Radix Pseudostellariae 13-25 part, Rhizoma Atractylodis Macrocephalae 18-32 part, Rhizoma Dioscoreae 16-26 part, Radix Et Caulis Acanthopanacis Senticosi 20-30 part, Fructus Hippophae 21-29 part, Poria 15-30 part, Semen Coicis 25-35 part, Herba Gnaphalii uliginosi 14-26 part, Parmelia saxatilis Ach. 16-22 part, Herba Inulae 13-27 part, Caulis Bambusae In Taenia 24-32 part, Herba Rorippae 19-29 part, Radix Ligulariae Dentatae 6-15 part, Indigo Naturalis 28-37 part, Radix Sophorae Viciifoliae 24-32 part and Radix Glycyrrhizae 29-40 part.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 21 parts of Rhizoma Atractylodis, 35 parts of Cortex Magnoliae Officinalis, 24 parts of Pericarpium Citri Reticulataes, 29 parts of Semen Raphanis, 16 parts of fevervines, 6 parts of the Rhizoma Pinelliaes, 4 parts of Rhizoma Arisaematiss, 8 parts, Fructus Gleditsia, 19 parts of Rhizoma Cynanchi Stauntoniis, 30 parts of Radix Platycodoniss, 5 parts of Semen Armeniacae Amarums, 19 parts of Flos Farfaraees, 12 parts of Folium Eriobotryaes, 8 parts of Semen Ginkgoes, 3 parts of Radix Physochlainae, 28 parts of Fructus Momordicaes, join very much 13 parts, 23 parts of the Rhizoma Atractylodis Macrocephalaes, 16 parts of Rhizoma Dioscoreaes, 26 parts of Radix Et Caulis Acanthopanacis Senticosis, 28 parts of Fructus Hippophaes, 30 parts, Poria, 35 parts of Semen Coiciss, 17 parts of Herba Gnaphalii uliginosi, 22 parts of Parmelia saxatilis Ach., 15 parts of Herba Inulae, 32 parts of Caulis Bambusae In Taenia, 23 parts of Herba Rorippae, 6 parts of Radix Ligulariae Dentataes, 35 parts of Indigo Naturaliss, 38 parts, 32 parts of Radix Sophorae Viciifoliae and Radix Glycyrrhizae.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 32 parts of Rhizoma Atractylodis, 40 parts of Cortex Magnoliae Officinalis, 16 parts of Pericarpium Citri Reticulataes, 35 parts of Semen Raphanis, 28 parts of fevervines, 4 parts of the Rhizoma Pinelliaes, 5 parts of Rhizoma Arisaematiss, 6 parts, Fructus Gleditsia, 33 parts of Rhizoma Cynanchi Stauntoniis, 32 parts of Radix Platycodoniss, 6 parts of Semen Armeniacae Amarums, 31 parts of Flos Farfaraees, 22 parts of Folium Eriobotryaes, 5 parts of Semen Ginkgoes, 4 parts of Radix Physochlainae, 18 parts of Fructus Momordicaes, 25 parts of Radix Pseudostellariaes, 32 parts of the Rhizoma Atractylodis Macrocephalaes, 18 parts of Rhizoma Dioscoreaes, 20 parts of Radix Et Caulis Acanthopanacis Senticosis, 21 parts of Fructus Hippophaes, 27 parts, Poria, 25 parts of Semen Coiciss, 26 parts of Herba Gnaphalii uliginosi, 19 parts of Parmelia saxatilis Ach., 27 parts of Herba Inulae, 24 parts of Caulis Bambusae In Taenia, 29 parts of Herba Rorippae, 15 parts of Radix Ligulariae Dentataes, 37 parts of Indigo Naturaliss, 40 parts, 24 parts of Radix Sophorae Viciifoliae and Radix Glycyrrhizae.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 28 parts of Rhizoma Atractylodis, 27 parts of Cortex Magnoliae Officinalis, 30 parts of Pericarpium Citri Reticulataes, 25 parts of Semen Raphanis, 23 parts of fevervines, 3 parts of the Rhizoma Pinelliaes, 7 parts of Rhizoma Arisaematiss, 5 parts, Fructus Gleditsia, 29 parts of Rhizoma Cynanchi Stauntoniis, 24 parts of Radix Platycodoniss, 9 parts of Semen Armeniacae Amarums, 17 parts of Flos Farfaraees, 16 parts of Folium Eriobotryaes, 4 parts of Semen Ginkgoes, 7 parts of Radix Physochlainae, 23 parts of Fructus Momordicaes, 20 parts of Radix Pseudostellariaes, 18 parts of the Rhizoma Atractylodis Macrocephalaes, 26 parts of Rhizoma Dioscoreaes, 30 parts of Radix Et Caulis Acanthopanacis Senticosis, 29 parts of Fructus Hippophaes, 15 parts, Poria, 33 parts of Semen Coiciss, 14 parts of Herba Gnaphalii uliginosi, 16 parts of Parmelia saxatilis Ach., 13 parts of Herba Inulae, 31 parts of Caulis Bambusae In Taenia, 19 parts of Herba Rorippae, 12 parts of Radix Ligulariae Dentataes, 28 parts of Indigo Naturaliss, 29 parts, 30 parts of Radix Sophorae Viciifoliae and Radix Glycyrrhizae.

When the dosage form of described Chinese medicine is spray, its preparation method comprises the following steps:

A, in described ratio, take all raw medicinal materials, add the water soaking 3-10 hour doubly with respect to the mixture quality 3-5 obtaining, after intense fire boils, using slow fire instead, to decoct slowly the 30-50 minute dosage to medicinal liquid be 100-300ml, decoct 3 times, merge decoction liquor and filter, filtrate is heated to obtain extractum 1, and medicinal residues are standby;

B, the medicinal residues of step a are added to 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid,, 80-160 order filters, getting the 6000-10000 rev/min of supernatant after centrifugal, is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, 1.35 extractum 2 when ultrafiltrate concentrating under reduced pressure obtains relative density and is 80 ℃;

C, extractum 1 and extractum 2 is mixed, thin up obtains spray.

The dosage form of described Chinese medicine is that while containing tablet, its preparation method comprises the following steps:

The first step, ratio described in Rhizoma Atractylodis, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Semen Raphani, fevervine, the Rhizoma Pinelliae, Rhizoma Arisaematis, Fructus Gleditsia, Rhizoma Cynanchi Stauntonii and Radix Platycodonis is mixed, use the soak with ethanol with respect to the determining alcohol 90%～95% of 4～6 times of the mixture quality obtaining, reflux was extracted after 2～4 hours, filtered; Filtering residue is used to the soak with ethanol with respect to the determining alcohol 85%～95% of 2～4 times of the mixture quality obtaining again, and reflux was extracted after 1～2 hour, filtered; Merge filtrate twice, decompression recycling ethanol to be concentrated into liquor strength be 0.8～1.2g crude drug/mL, utilize twice of the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, with the determining alcohol of 3 times of resin column volumes, be 90%～95% ethanol elution again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;

Second step, Semen Armeniacae Amarum, Flos Farfarae, Folium Eriobotryae, Semen Ginkgo, Radix Physochlainae, Fructus Momordicae and Radix Pseudostellariae are mixed in described ratio, the alcohol heating reflux adding with respect to the determining alcohol 85%～95% of 3～5 times of the mixture quality obtaining extracts 2 times, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 ℃ under the condition of 60 ℃～70 ℃, relative density is 1.20～1.23, is dried to powder by the mastic after concentrated with spray dryer;

The 3rd step, mixes surplus stock medical material in described ratio, add the water soaking of 2～5 times with respect to the mixture quality obtaining, and heating decocts 2～4 hours, filters; Filtering residue is used to the water soaking of 1～3 times with respect to the mixture quality obtaining again, and heating decocts 1～2 hour, filters; Merge filtrate twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;

The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, further add with respect to the carboxymethyl starch sodium of 0.05～0.1 times of the mixture quality obtaining, the microcrystalline Cellulose of 0.05～0.1 times, mix, granulate, after being dried, add the magnesium stearate with respect to 0.01～0.05 times of the mixture quality obtaining, then with decompressor by granule compacting in flakes, obtain containing tablet.

When the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:

Step 1: described raw medicinal material is mixed in described ratio, add the ethanol that the determining alcohol with respect to 4～8 times, mixture is 85%～95%, be heated to boiling reflux 3～5 hours, filter, adopt percolation with the speed of 1～2ml per minute percolation slowly, collect percolate, the mastic that while being evaporated to 50～60 ℃ subsequently under vacuum 0.06～0.09Mpa, relative density is 1.04～1.10, spraying is dry, 160～175 ℃ of the inlet temperature of spray dryer, 80～85 ℃ of leaving air temps, be ground into subsequently powder, make dried cream powder;

Step 2: in the dried cream powder obtaining, add with respect to the cane sugar powder of 0.2～0.4 times of dried cream powder quality and the dextrin of 0.1～0.2 times, granulation, in 40～50 ℃ dry, obtain granule.

The beneficial effect that technical scheme provided by the invention is brought is: the present invention has drying dampness to eliminate phlegm, and the effect of the cough-relieving of regulating the flow of vital energy cures mainly phlegm-damp and violates pulmonary type chronic bronchitis.The present invention utilizes Traditional Chinese medical theory, on the basis of Overall View, by regulating qi-blood circulating, enhancing human body immunity power, carries out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, according to the many target treatments of different diseases, expansion bronchus, strengthen the respiratory function of respiratory muscle, promote expectoration cough-relieving, relieving asthma, keep respiratory passage unblocked, the drug effect focus of going directly, safe and effective, the course for the treatment of is shorter, and be difficult for to produce that drug resistance, cost price are lower, convenient drug administration, patient is easy to accept, can obviously improve cure rate, reduce complication, reduce relapse rate, significantly improve patient's quality of life etc.

 

The specific embodiment

Chronic bronchitis is mainly reflected as lung, spleen, kidney three deficiency of five ZANG-organs and damages on pathogenesis, and their mutual relation is unbalance, simultaneously again because of the participation more sophisticated of the factors such as expectorant, fire, the stasis of blood.Its basic pathogenesis is deficiency in origin and excess in superficiality.Under normal circumstances, lung governing qi, department breathes, and main Xuan Fasu falls, and closes fur outward, is the passage of mechanism of qi discrepancy lifting.The dry heresy of wind and cold heat is entered by mouth and nose or fur, and lung qi is restrainted, and loses its respectful falling and falls ill; Have a liking for food tobacco and wine, the pungent product that help fire, expectorant is given birth in the Tianjin of burning, and obstructing airway all can make abnormal rising of lung-QI and coughs.Disease does not heal for a long time, lung qi wound healing, and the unable imperial heresy of healthy energy, exopathogen is easily violated again again, so that delay is with the passing of time, does not touchingly heal.The spleen has the function to transport and transform nutrients, occupies middle Jiao, is the pivot of rising and falling of QI.Insufficiency of the spleen can not transmitting and distributing the fluids, poly-wetting as expectorant, steeps on damp-phlegm in lung, affects the unobstructed of mechanism of qi and sees cough with asthma, the disease such as cough up phlegm.Kidney governing inspiration, kidney yang virtual loss, gas loses to take the photograph and receives, decline of the fire from the gate of life, defeatedization of body fluid mistake department, lung qi lifting is obstructed, and gasification function is not normal, and aqueous vapor can not Xuanhua, for expectorant is for drinking, obstructing airway; Damage of kidney-YIN, vehement in asthenic fire, the lung Tianjin of burning, all can make impairment of dispersing and descending function of the lung, abnormal rising of lung-QI and cough with asthma is coughed up phlegm.Ancients are so-called: " the kidney being the origin of producing phlegm, the lung being the utensil for storing phlegm, the spleen being the source of producing phlegm ", " lung is not hindered and do not coughed, and spleen is not hindered not chronic cough, kidney do not hinder not cough breathe heavily ", illustrates that lung spleen kidney three dirty functional disorders can cause primary disease.Expectorant, fire, the stasis of blood are the pathological product of zang-fu disharmony, are again direct or indirect pathogenic factors.Be no matter the outer scorching heresy that is subject to, or cold strongly fragrant and heat-transformation, or overaction of the five emotions, hungry full overstrain injures internal organs and causes endogenous fire that functional disorder is given birth to, and all can intimately stop up lung with phlegm-damp etc. in conjunction with formation phlegm-fire, unconsciousness due to blockage of phlegm lung network and falling ill.Prolonged illness multiple deficiency and stasis, YANG QI deficiency, can not warm blood vessels and promote blood operation; Or because cold-evil visitor enters blood vessels, blood stagnation is not smooth; Or heat enters nutrient blood, the heat in blood knot etc. of fighting, all can form blood stasis.

Therefore, treatment phlegm-damp is violated pulmonary type chronic bronchitis, the present invention is with drying dampness to eliminate phlegm, the cough-relieving of regulating the flow of vital energy is primary treatment principle, selects prescription: Rhizoma Atractylodis, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Semen Raphani, fevervine, the Rhizoma Pinelliae, Rhizoma Arisaematis, Fructus Gleditsia, Rhizoma Cynanchi Stauntonii, Radix Platycodonis, Semen Armeniacae Amarum, Flos Farfarae, Folium Eriobotryae, Semen Ginkgo, Radix Physochlainae, Fructus Momordicae, Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Fructus Hippophae, Poria, Semen Coicis, Herba Gnaphalii uliginosi, Parmelia saxatilis Ach., Herba Inulae, Caulis Bambusae In Taenia, Herba Rorippae, Radix Ligulariae Dentatae Indigo Naturalis, Radix Sophorae Viciifoliae and Radix Glycyrrhizae.

Wherein, Rhizoma Atractylodis, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Semen Raphani, fevervine, Herba Gnaphalii uliginosi, Parmelia saxatilis Ach. and the Herba Inulae drying dampness to eliminate phlegm of regulating the flow of vital energy; The Rhizoma Pinelliae, Rhizoma Arisaematis, Fructus Gleditsia, Rhizoma Cynanchi Stauntonii, Radix Platycodonis, Caulis Bambusae In Taenia, Herba Rorippae and Radix Ligulariae Dentatae warming the lung for resolving phlegm; Semen Armeniacae Amarum, Flos Farfarae, Folium Eriobotryae, Semen Ginkgo, Radix Physochlainae, Fructus Momordicae, relieving cough and asthma; Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Fructus Hippophae, Poria, Semen Coicis tonifying the lung, replenishing QI to invigorate the spleen; Indigo Naturalis, Radix Sophorae Viciifoliae and Radix Glycyrrhizae heat-clearing and toxic substances removing.

The invention provides a kind of Chinese medicine that phlegm-damp is violated pulmonary type chronic bronchitis for the treatment of, wherein, comprise following raw medicinal material: Rhizoma Atractylodis, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Semen Raphani, fevervine, the Rhizoma Pinelliae, Rhizoma Arisaematis, Fructus Gleditsia, Rhizoma Cynanchi Stauntonii, Radix Platycodonis, Semen Armeniacae Amarum, Flos Farfarae, Folium Eriobotryae, Semen Ginkgo, Radix Physochlainae, Fructus Momordicae, Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Fructus Hippophae, Poria, Semen Coicis, Herba Gnaphalii uliginosi, Parmelia saxatilis Ach., Herba Inulae, Caulis Bambusae In Taenia, Herba Rorippae, Radix Ligulariae Dentatae, Indigo Naturalis, Radix Sophorae Viciifoliae and Radix Glycyrrhizae.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Rhizoma Atractylodis: nature and flavor are pungent, bitter, temperature.Return spleen, stomach, Liver Channel.The transporting imbalance that the spleen being blocked by dampness causes, inappetence, vomiting is unhappy, and abdominal distention is had loose bowels, arthralgia.For dampness taste, distension and fullness in the abdomen, cold-damp leucorrhea, damp-warm diseases and damp invasion of lower energizer, foot swelling and pain in knee, flaccidity are soft unable.

Cortex Magnoliae Officinalis: hardship, pungent, warm in nature.Return spleen channel, stomach warp, large intestine channel.Circulation of qi promoting removing food stagnancy, dampness is removed full, lowering the adverse QI to relieve asthma.

Pericarpium Citri Reticulatae: nature and flavor are bitter, pungent, temperature.Return lung, spleen channel.There is regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm.Can be used for fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.

Semen Raphani: property is flat, acrid in the mouth, sweet.Return lung, spleen, stomach warp.The de-swelling that helps digestion, lowering the adverse-rising QI to resolve phlegm.Cure mainly stagnation of QI due to dyspepsia, distension and fullness in the abdomen, belch, heavy after dysentery, cough with copious phlegm, dyspnea with rapid and short breath fullness in the chest.For retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant, stop up and breath with cough.Enter spleen, stomach, lung meridian, the de-swelling that can help digestion, effect is remarkable.

Fevervine: property is flat, sweet in the mouth, micro-hardship.Expelling wind and activating blood circulation, analgesic antidotal, dyspepsia and intestinal stasis relieving, dehumidifying detumescence.Dispelling the wind and dampness pathogens pain, diarrhoea dysentery, dirty abdomen pain, deficiency of vital energy edema, dizzy lack of appetite, hepatosplenomegaly, scrofula, acute appendicitis, innominate toxic swelling, traumatic injury.

The Rhizoma Pinelliae: pungent, temperature.Return lung, spleen, stomach three warps.Drying dampness to eliminate phlegm; Stopping nausea and vomiting by lowering the adverse flow of QI; Dissolving lump and resolving mass.Main cough with asthma abundant expectoration; Vomiting regurgitation; Feeling of oppression and fullness in the chest and epigastrium headache is dizzy; Uneasy sleeping at night; Gall subcutaneous nodule; Swollen ulcer drug.

Rhizoma Arisaematis: bitter, pungent, temperature.Return lung, liver, spleen channel.Drying dampness to eliminate phlegm, expellings wind and relieving convulsion, mass dissipating and swelling eliminating.For pertinacious phlegm cough, wind disease is dizzy, and middle wind-phlegm is stopped up, facial hemiparalysis, hemiplegia, epilepsy, infantile convulsion, tetanus; Outward for carbuncle, snake bite and insect sting.

Fructus Gleditsia: pungent, temperature.Return lung, Liver Channel.Expelling phlegm for arresting cough; Have one's ideas straightened out to lead to and close; Parasite killing eliminating stagnation.Main productive cough dyspnea with fullness of the chest; Apoplexy locked mouth; Accumulation and obstruction of sputum; Coma in silence; Epilepsy; Sore throat; Constipation and anuresis; Carbuncle scabies.

Rhizoma Cynanchi Stauntonii: pungent, bitter, tepor.Return lung meridian.Lowering the adverse-rising QI to resolve phlegm, cough-relieving.Cough with copious phlegm, asthma.This product slightly warm in nature and not dry strong, is longer than and eliminates the phlegm, and falls lung qi with flat cough with asthma.The cold heat that belongs to of genus no matter, Exogenous and internal injuries, newly cough chronic cough all available it.

Radix Platycodonis: bitter in the mouth, pungent, property is flat.Return lung meridian.There is lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, the effect that fills blood, mend five kinds of over strain, foster the spirit of nobility.Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.

Semen Armeniacae Amarum: bitter, tepor.Return liver, large intestine channel.Sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.For cough and asthma, fullness in the chest abundant expectoration, blood deficiency Tianjin is withered, dryness of the intestine constipation.Be good at falling lung qi and relieving asthma, control breathing with cough of excess of the lung.

Flos Farfarae: acrid in the mouth, warm in nature.Return lung meridian.Preventing phlegm from forming and stopping coughing.There is the antitussive therapeutic method to keep the adverse QI flowing downwards, the function that lung moistening is eliminated the phlegm.For cough, asthma, consumptive lung disease, coughs the diseases such as blood of spitting.

Folium Eriobotryae: hardship, is slightly cold.Return lung, stomach warp.Clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.Cough due to lung-heat, QI rising in reverse order dyspnea with rapid respiration, gastropyretic vomiting, hiccup.Can treat xerostomia and quench one's thirst, lung-wind syndrome acne vulgaris, acne.

Semen Ginkgo: property is flat, sweet in the mouth is pained.Return lung, kidney channel.The gas of astringing the lung, relieving asthma and cough, leukorrhagia stopping is turbid, urine reducing, disinfection.Cure mainly asthma, phlegmatic cough, nocturnal emission, leucorrhea, nebulousurine, infantile diarrhea, malnutrition due to parasitic infestation, hemorrhoidal hamorrhage dysentery, gonorrhea, frequent micturition, and the disease such as scabies, dermatitis rhus, white tumor wind.

Radix Physochlainae: sweet in the mouth; Micro-hardship; Puckery; Hot in nature.Expelling phlegm for arresting cough is relievingd asthma.Main cough with asthma excessive phlegm, relieving cough and asthma, calms the nerves relieving convulsion.For cold-phlegm, breath with cough, palpitation and insomnia is easily frightened, strain weak, and spontaneous sweating.

Fructus Momordicae: cool in nature, sweet in the mouth.Return lung, large intestine channel.Clearing heat and moistening lung, cough-relieving, sore-throat relieving, laxation relieving constipation.For lung-fire cough caused by dryness, pharyngalgia aphonia, dryness of the intestine constipation.

Radix Pseudostellariae: sweet in the mouth, micro-hardship, property is flat.Return spleen, lung meridian.Control the deficiency of vital energy dryness of the lung, spleen reinforcing soil, consumer edema, reduces phlegm and quenches the thirst.Invigorating qi and benefiting blood, spleen invigorating is promoted the production of body fluid.After curing the disease, body is empty, cough due to deficiency of the lung, insufficiency of the spleen diarrhoea, children's's sweating due to debility, cardiopalmus, xerostomia, anorexia.The effect with air making-up and spleen enlivening, the lung moistening and production of body fluid promoting, cures mainly the inappetence due to deficiency-weakness of spleen-QI, fatigue and weakness, and deficiency of the lung cough caused by dryness, dyspnea with rapid and short breath is breathed hard, the convalescent stage of febrile disease, gas Tianjin two wounds, the thirsty card that waits of interior-heat.

The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature.Return spleen, stomach warp.There is spleen reinforcing promoting the circulation of QI, dampness diuretic, strengthening superficial resistance to stop perspiration, the effect that activating the spleen is moisturized, cures mainly the feeling of fullness diarrhoea due to dysfunction of the spleen in transportation, QI failing to transform into body fluid, phlegm retention edema; The vexed lazy speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration.

Rhizoma Dioscoreae: sweet in the mouth, property is flat.Return lung, spleen, kidney channel.There is strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help that the five internal organs, bone and muscle strengthening, long will are calmed the nerves, the effect of life lengthening, cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity are weak, the red card such as swollen, fat of the frequent micturition of quenching one's thirst, the premature ejaculation of passing out semen, leukorrhagia nebulousurine, skin.

Radix Et Caulis Acanthopanacis Senticosi: acrid in the mouth, hardship, micro-sweet, warm in nature.Return spleen, kidney, heart channel.There is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, the effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, a little less than body weakness with emaciation, traumatic injury, fracture, edema, beriberi, the uncontrolled urination card such as itch.

Fructus Hippophae: sour, puckery, temperature.Eliminating phlegm and stopping cough, relieving dyspepsia, promoting blood circulation to remove blood stasis.For cough with copious phlegm, dyspepsia, abdominal pain due to retention of food, blood stasis amenorrhea, falls and flutters congestive edema.

Poria: sweet, light, flat.GUIXIN warp, lung meridian, spleen channel, kidney channel.Function: diuretic medicine; Diuretics with the action of eliminating dampness.Poria, the sharp key of light energy, sweet with supporing yang, the panacea of dehumidifying is also.The flat YANG invigorating of sweet in the mouth, strengthening the spleen is relieved oedema or abdominal distension through diuresis or purgation, the inducing QI of promoting the production of body fluid.

Semen Coicis: sweet; Light; Be slightly cold.Return spleen; Lung; Kidney channel.Dampness removing spleen invigorating; Arthralgia relieving by relaxing muscles and tendons; Clearing away heat and discharging pus.Main edema; Foot gas; Dribbling urination; Damp-warm diseases; The leukorrhagia of having loose bowels; Rheumatic arthralgia; The contracture of muscle arteries and veins; Lung abscess; Intestinal carbuncle; Verruca plana.

Herba Gnaphalii uliginosi: sweet in the mouth; Light; Property is put down.Relieving cough and resolving phlegm; Adjust institute and in; Heat clearing away suppressing the hyperactive liver.Main bronchus is scorching; Gastric ulcer; Hygropyretic dysentery; Sore and toxic; Hypertension.

Parmelia saxatilis Ach.: sweet; Property is put down.Return liver; Kidney channel.Invigrating kidney; Improving eyesight; Hemostasis, eliminating damp, detoxifying.。Main blurred vision; Lumbocrural pain; Spit blood; Metrorrhagia jaundice, skin ulcer tinea.

Herba Inulae: bitter, pungent, salty, temperature.Return lung, large intestine channel.Sending down the abnormal ascending QI, expectorant, row water.For cough due to wind and cold, phlegm retention is held knot, and expectorant is stopped up QI rising in reverse order, chest and diaphragm feeling of fullness, dyspnea and cough with excessive sputum; External treatment furuncle swelling toxin.

Caulis Bambusae In Taenia: sweet; Be slightly cold.Return spleen; Stomach; Gallbladder meridian.Removing heat-phlegm; Relieve restlessness and prevent vomiting; Antiabortive removing heat from blood.Main cough due to lung-heat; Dysphoria with smothery sensation palpitation with fear; Gastric heat is vomitted oh; Pregnancy reactions; Frequent fetal movement; Spit blood; Epistaxis; Hematuria; Metrorrhagia.

Herba Rorippae: acrid in the mouth; Bitter; Slightly warm in nature.Return lung; Liver Channel.Expelling phlegm for arresting cough; Cold expelling induces sweat; Promoting blood circulation and detoxication; Dampness removing jaundice eliminating.Main cough phlegm dyspnea; Cold, fever; Measles is sent out not smooth thoroughly; Rheumatic arthralgia; Laryngopharynx swelling and pain; Furuncle carbuncle; Dermatitis rhus; Amenorrhea; Traumatic injury; Jaundice; Edema.

Radix Ligulariae Dentatae: sweet, acrid, warm.Vital energy regualting and blood circulation-promoting, pain relieving, eliminating phlegm and stopping cough.Control traumatic injury, impairment caused by overstrain, lumbago and skelalgia, cough and asthma, pertussis, lung abscess spitting of blood.

Indigo Naturalis: salty, cold.Return Liver Channel.Heat-clearing and toxic substances removing, removing heat from blood, arresting convulsion.For maculae caused by violent heat pathogen, heat in blood is told nosebleed, chest pain hemoptysis, aphtha, mumps, sore throat, pediatric epilepsy scared.

Radix Sophorae Viciifoliae: bitter in the mouth; Cool in nature.Return liver; Urinary bladder channel.Heat-clearing and toxic substances removing, inducing diuresis and reducing edema.Control dysentery, cystitis, hematuria, edema.

Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material is: Rhizoma Atractylodis 20-34 part, Cortex Magnoliae Officinalis 27-42 part, Pericarpium Citri Reticulatae 14-32 part, Semen Raphani 23-39 part, fevervine 14-30 part, Rhizoma Pinelliae 3-8 part, Rhizoma Arisaematis 4-9 part, Fructus Gleditsia 5-10 part, Rhizoma Cynanchi Stauntonii 17-35 part, Radix Platycodonis 22-36 part, Semen Armeniacae Amarum 5-11 part, Flos Farfarae 15-33 part, Folium Eriobotryae 10-25 part, Semen Ginkgo 4-10 part, Radix Physochlainae 3-9 part, Fructus Momordicae 18-31 part, Radix Pseudostellariae 11-27 part, Rhizoma Atractylodis Macrocephalae 16-37 part, Rhizoma Dioscoreae 15-27 part, Radix Et Caulis Acanthopanacis Senticosi 19-34 part, Fructus Hippophae 20-34 part, Poria 13-32 part, Semen Coicis 23-38 part, Herba Gnaphalii uliginosi 12-28 part, Parmelia saxatilis Ach. 12-27 part, Herba Inulae 13-30 part, Caulis Bambusae In Taenia 24-37 part, Herba Rorippae 19-33 part, Radix Ligulariae Dentatae 6-19 part, Indigo Naturalis 26-39 part, Radix Sophorae Viciifoliae 21-33 part and Radix Glycyrrhizae 27-42 part.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material is: Rhizoma Atractylodis 21-32 part, Cortex Magnoliae Officinalis 27-40 part, Pericarpium Citri Reticulatae 16-30 part, Semen Raphani 25-35 part, fevervine 16-28 part, Rhizoma Pinelliae 3-6 part, Rhizoma Arisaematis 4-7 part, Fructus Gleditsia 5-8 part, Rhizoma Cynanchi Stauntonii 19-33 part, Radix Platycodonis 24-32 part, Semen Armeniacae Amarum 5-9 part, Flos Farfarae 17-31 part, Folium Eriobotryae 12-22 part, Semen Ginkgo 4-8 part, Radix Physochlainae 3-7 part, Fructus Momordicae 18-28 part, Radix Pseudostellariae 13-25 part, Rhizoma Atractylodis Macrocephalae 18-32 part, Rhizoma Dioscoreae 16-26 part, Radix Et Caulis Acanthopanacis Senticosi 20-30 part, Fructus Hippophae 21-29 part, Poria 15-30 part, Semen Coicis 25-35 part, Herba Gnaphalii uliginosi 14-26 part, Parmelia saxatilis Ach. 16-22 part, Herba Inulae 13-27 part, Caulis Bambusae In Taenia 24-32 part, Herba Rorippae 19-29 part, Radix Ligulariae Dentatae 6-15 part, Indigo Naturalis 28-37 part, Radix Sophorae Viciifoliae 24-32 part and Radix Glycyrrhizae 29-40 part.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material is: 21 parts of Rhizoma Atractylodis, 35 parts of Cortex Magnoliae Officinalis, 24 parts of Pericarpium Citri Reticulataes, 29 parts of Semen Raphanis, 16 parts of fevervines, 6 parts of the Rhizoma Pinelliaes, 4 parts of Rhizoma Arisaematiss, 8 parts, Fructus Gleditsia, 19 parts of Rhizoma Cynanchi Stauntoniis, 30 parts of Radix Platycodoniss, 5 parts of Semen Armeniacae Amarums, 19 parts of Flos Farfaraees, 12 parts of Folium Eriobotryaes, 8 parts of Semen Ginkgoes, 3 parts of Radix Physochlainae, 28 parts of Fructus Momordicaes, join very much 13 parts, 23 parts of the Rhizoma Atractylodis Macrocephalaes, 16 parts of Rhizoma Dioscoreaes, 26 parts of Radix Et Caulis Acanthopanacis Senticosis, 28 parts of Fructus Hippophaes, 30 parts, Poria, 35 parts of Semen Coiciss, 17 parts of Herba Gnaphalii uliginosi, 22 parts of Parmelia saxatilis Ach., 15 parts of Herba Inulae, 32 parts of Caulis Bambusae In Taenia, 23 parts of Herba Rorippae, 6 parts of Radix Ligulariae Dentataes, 35 parts of Indigo Naturaliss, 38 parts, 32 parts of Radix Sophorae Viciifoliae and Radix Glycyrrhizae.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material is: 32 parts of Rhizoma Atractylodis, 40 parts of Cortex Magnoliae Officinalis, 16 parts of Pericarpium Citri Reticulataes, 35 parts of Semen Raphanis, 28 parts of fevervines, 4 parts of the Rhizoma Pinelliaes, 5 parts of Rhizoma Arisaematiss, 6 parts, Fructus Gleditsia, 33 parts of Rhizoma Cynanchi Stauntoniis, 32 parts of Radix Platycodoniss, 6 parts of Semen Armeniacae Amarums, 31 parts of Flos Farfaraees, 22 parts of Folium Eriobotryaes, 5 parts of Semen Ginkgoes, 4 parts of Radix Physochlainae, 18 parts of Fructus Momordicaes, 25 parts of Radix Pseudostellariaes, 32 parts of the Rhizoma Atractylodis Macrocephalaes, 18 parts of Rhizoma Dioscoreaes, 20 parts of Radix Et Caulis Acanthopanacis Senticosis, 21 parts of Fructus Hippophaes, 27 parts, Poria, 25 parts of Semen Coiciss, 26 parts of Herba Gnaphalii uliginosi, 19 parts of Parmelia saxatilis Ach., 27 parts of Herba Inulae, 24 parts of Caulis Bambusae In Taenia, 29 parts of Herba Rorippae, 15 parts of Radix Ligulariae Dentataes, 37 parts of Indigo Naturaliss, 40 parts, 24 parts of Radix Sophorae Viciifoliae and Radix Glycyrrhizae.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material is: 28 parts of Rhizoma Atractylodis, 27 parts of Cortex Magnoliae Officinalis, 30 parts of Pericarpium Citri Reticulataes, 25 parts of Semen Raphanis, 23 parts of fevervines, 3 parts of the Rhizoma Pinelliaes, 7 parts of Rhizoma Arisaematiss, 5 parts, Fructus Gleditsia, 29 parts of Rhizoma Cynanchi Stauntoniis, 24 parts of Radix Platycodoniss, 9 parts of Semen Armeniacae Amarums, 17 parts of Flos Farfaraees, 16 parts of Folium Eriobotryaes, 4 parts of Semen Ginkgoes, 7 parts of Radix Physochlainae, 23 parts of Fructus Momordicaes, 20 parts of Radix Pseudostellariaes, 18 parts of the Rhizoma Atractylodis Macrocephalaes, 26 parts of Rhizoma Dioscoreaes, 30 parts of Radix Et Caulis Acanthopanacis Senticosis, 29 parts of Fructus Hippophaes, 15 parts, Poria, 33 parts of Semen Coiciss, 14 parts of Herba Gnaphalii uliginosi, 16 parts of Parmelia saxatilis Ach., 13 parts of Herba Inulae, 31 parts of Caulis Bambusae In Taenia, 19 parts of Herba Rorippae, 12 parts of Radix Ligulariae Dentataes, 28 parts of Indigo Naturaliss, 29 parts, 30 parts of Radix Sophorae Viciifoliae and Radix Glycyrrhizae.

Wherein, when the dosage form of Chinese medicine is spray, its preparation method comprises the following steps:

A, in described ratio, take all raw medicinal materials, add the water soaking 3-10 hour doubly with respect to the mixture quality 3-5 obtaining, after intense fire boils, using slow fire instead, to decoct slowly the 30-50 minute dosage to medicinal liquid be 100-300ml, decoct 3 times, merge decoction liquor and filter, filtrate is heated to obtain extractum 1, and medicinal residues are standby;

B, the medicinal residues of step a are added to 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid,, 80-160 order filters, getting the 6000-10000 rev/min of supernatant after centrifugal, is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, 1.35 extractum 2 when ultrafiltrate concentrating under reduced pressure obtains relative density and is 80 ℃;

C, extractum 1 and extractum 2 is mixed, thin up obtains spray.

Wherein, the dosage form of Chinese medicine is that while containing tablet, its preparation method comprises the following steps:

The first step, ratio described in Rhizoma Atractylodis, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Semen Raphani, fevervine, the Rhizoma Pinelliae, Rhizoma Arisaematis, Fructus Gleditsia, Rhizoma Cynanchi Stauntonii and Radix Platycodonis is mixed, use the soak with ethanol with respect to the determining alcohol 90%～95% of 4～6 times of the mixture quality obtaining, reflux was extracted after 2～4 hours, filtered; Filtering residue is used to the soak with ethanol with respect to the determining alcohol 85%～95% of 2～4 times of the mixture quality obtaining again, and reflux was extracted after 1～2 hour, filtered; Merge filtrate twice, decompression recycling ethanol to be concentrated into liquor strength be 0.8～1.2g crude drug/mL, utilize twice of the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, with the determining alcohol of 3 times of resin column volumes, be 90%～95% ethanol elution again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;

Second step, Semen Armeniacae Amarum, Flos Farfarae, Folium Eriobotryae, Semen Ginkgo, Radix Physochlainae, Fructus Momordicae and Radix Pseudostellariae are mixed in described ratio, the alcohol heating reflux adding with respect to the determining alcohol 85%～95% of 3～5 times of the mixture quality obtaining extracts 2 times, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 ℃ under the condition of 60 ℃～70 ℃, relative density is 1.20～1.23, is dried to powder by the mastic after concentrated with spray dryer;

The 3rd step, mixes surplus stock medical material in described ratio, add the water soaking of 2～5 times with respect to the mixture quality obtaining, and heating decocts 2～4 hours, filters; Filtering residue is used to the water soaking of 1～3 times with respect to the mixture quality obtaining again, and heating decocts 1～2 hour, filters; Merge filtrate twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;

The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, further add with respect to the carboxymethyl starch sodium of 0.05～0.1 times of the mixture quality obtaining, the microcrystalline Cellulose of 0.05～0.1 times, mix, granulate, after being dried, add the magnesium stearate with respect to 0.01～0.05 times of the mixture quality obtaining, then with decompressor by granule compacting in flakes, obtain containing tablet.

Wherein, when the dosage form of Chinese medicine is granule, its preparation method comprises the following steps:

Step 1: described raw medicinal material is mixed in described ratio, add the ethanol that the determining alcohol with respect to 4～8 times, mixture is 85%～95%, be heated to boiling reflux 3～5 hours, filter, adopt percolation with the speed of 1～2ml per minute percolation slowly, collect percolate, the mastic that while being evaporated to 50～60 ℃ subsequently under vacuum 0.06～0.09Mpa, relative density is 1.04～1.10, spraying is dry, 160～175 ℃ of the inlet temperature of spray dryer, 80～85 ℃ of leaving air temps, be ground into subsequently powder, make dried cream powder;

Step 2: in the dried cream powder obtaining, add with respect to the cane sugar powder of 0.2～0.4 times of dried cream powder quality and the dextrin of 0.1～0.2 times, granulation, in 40～50 ℃ dry, obtain granule.

 

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

         

Embodiment 1 spray of the present invention

Get Rhizoma Atractylodis 21g, Cortex Magnoliae Officinalis 35g, Pericarpium Citri Reticulatae 24g, Semen Raphani 29g, fevervine 16g, Rhizoma Pinelliae 6g, Rhizoma Arisaematis 4g, Fructus Gleditsia 8g, Rhizoma Cynanchi Stauntonii 19g, Radix Platycodonis 30g, Semen Armeniacae Amarum 5g, Flos Farfarae 19g, Folium Eriobotryae 12g, Semen Ginkgo 8g, Radix Physochlainae 3g, Fructus Momordicae 28g, join very much 13g, Rhizoma Atractylodis Macrocephalae 23g, Rhizoma Dioscoreae 16g, Radix Et Caulis Acanthopanacis Senticosi 26g, Fructus Hippophae 28g, Poria 30g, Semen Coicis 35g, Herba Gnaphalii uliginosi 17g, Parmelia saxatilis Ach. 22g, Herba Inulae 15g, Caulis Bambusae In Taenia 32g, Herba Rorippae 23g, Radix Ligulariae Dentatae 6g, Indigo Naturalis 35g, Radix Sophorae Viciifoliae 32g and Radix Glycyrrhizae 38g.

Its preparation method comprises the following steps:

A, in described ratio, take all raw medicinal materials, add with respect to the water soaking of 3 times of the mixture qualities obtaining 10 hours, after intense fire boils, using slow fire instead, to decoct slowly the 30 minutes dosage to medicinal liquid be 300ml, decocts 3 times, merges decoction liquor and filter, filtrate is heated to obtain extractum 1, and medicinal residues are standby;

B, the medicinal residues of step a are added to 60% soak with ethanol 1.5 hours, extract twice, each 1 hour, merge extractive liquid,, 160 orders filter, 10000 revs/min of supernatant after centrifugal, are 10000 ultrafiltration post ultrafiltration through the molecular weight that dams, 1.35 extractum 2 when ultrafiltrate concentrating under reduced pressure obtains relative density and is 80 ℃;

C, extractum 1 and extractum 2 is mixed, thin up obtains spray.

       

Embodiment 2 is of the present invention containing tablet

Get Rhizoma Atractylodis 32g, Cortex Magnoliae Officinalis 40g, Pericarpium Citri Reticulatae 16g, Semen Raphani 35g, fevervine 28g, Rhizoma Pinelliae 4g, Rhizoma Arisaematis 5g, Fructus Gleditsia 6g, Rhizoma Cynanchi Stauntonii 33g, Radix Platycodonis 32g, Semen Armeniacae Amarum 6g, Flos Farfarae 31g, Folium Eriobotryae 22g, Semen Ginkgo 5g, Radix Physochlainae 4g, Fructus Momordicae 18g, Radix Pseudostellariae 25g, Rhizoma Atractylodis Macrocephalae 32g, Rhizoma Dioscoreae 18g, Radix Et Caulis Acanthopanacis Senticosi 20g, Fructus Hippophae 21g, Poria 27g, Semen Coicis 25g, Herba Gnaphalii uliginosi 26g, Parmelia saxatilis Ach. 19g, Herba Inulae 27g, Caulis Bambusae In Taenia 24g, Herba Rorippae 29g, Radix Ligulariae Dentatae 15g, Indigo Naturalis 37g, Radix Sophorae Viciifoliae 24g and Radix Glycyrrhizae 40g.

Its preparation method comprises the following steps:

The first step, ratio described in Rhizoma Atractylodis, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Semen Raphani, fevervine, the Rhizoma Pinelliae, Rhizoma Arisaematis, Fructus Gleditsia, Rhizoma Cynanchi Stauntonii and Radix Platycodonis is mixed, use the soak with ethanol with respect to the determining alcohol 95% of 5 times of the mixture quality obtaining, reflux was extracted after 3 hours, filtered; Filtering residue is used to the soak with ethanol with respect to the determining alcohol 95% of 2 times of the mixture quality obtaining again, and reflux was extracted after 1 hour, filtered; Merge filtrate twice, decompression recycling ethanol to be concentrated into liquor strength be 1.2g crude drug/mL, utilize twice of the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, with the determining alcohol of 3 times of resin column volumes, be 95% ethanol elution again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;

Second step, Semen Armeniacae Amarum, Flos Farfarae, Folium Eriobotryae, Semen Ginkgo, Radix Physochlainae, Fructus Momordicae and Radix Pseudostellariae are mixed in described ratio, the alcohol heating reflux adding with respect to the determining alcohol 95% of 5 times of the mixture quality obtaining extracts 2 times, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 ℃ under the condition of 70 ℃, relative density is 1.23, is dried to powder by the mastic after concentrated with spray dryer;

The 3rd step, mixes surplus stock medical material in described ratio, add the water soaking of 3 times with respect to the mixture quality obtaining, and heating decocts 3 hours, filters; Filtering residue is used to the water soaking of 2 times with respect to the mixture quality obtaining again, and heating decocts 1 hour, filters; Merge filtrate twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;

The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, further add with respect to the carboxymethyl starch sodium of 0.08 times of the mixture quality obtaining, the microcrystalline Cellulose of 0.08 times, mix, granulate, after being dried, add the magnesium stearate with respect to 0.02 times of the mixture quality obtaining, then with decompressor by granule compacting in flakes, obtain containing tablet.

 

Embodiment 3 granule of the present invention

Get Rhizoma Atractylodis 28g, Cortex Magnoliae Officinalis 27g, Pericarpium Citri Reticulatae 30g, Semen Raphani 25g, fevervine 23g, Rhizoma Pinelliae 3g, Rhizoma Arisaematis 7g, Fructus Gleditsia 5g, Rhizoma Cynanchi Stauntonii 29g, Radix Platycodonis 24g, Semen Armeniacae Amarum 9g, Flos Farfarae 17g, Folium Eriobotryae 16g, Semen Ginkgo 4g, Radix Physochlainae 7g, Fructus Momordicae 23g, Radix Pseudostellariae 20g, Rhizoma Atractylodis Macrocephalae 18g, Rhizoma Dioscoreae 26g, Radix Et Caulis Acanthopanacis Senticosi 30g, Fructus Hippophae 29g, Poria 15g, Semen Coicis 33g, Herba Gnaphalii uliginosi 14g, Parmelia saxatilis Ach. 16g, Herba Inulae 13g, Caulis Bambusae In Taenia 31g, Herba Rorippae 19g, Radix Ligulariae Dentatae 12g, Indigo Naturalis 28g, Radix Sophorae Viciifoliae 30g and Radix Glycyrrhizae 29g.

Its preparation method comprises the following steps:

Step 1: described raw medicinal material is mixed in described ratio, add the ethanol that the determining alcohol with respect to 5 times, mixture is 95%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 2ml per minute percolation slowly, collect percolate, the mastic that while being evaporated to 60 ℃ subsequently under vacuum 0.07Mpa, relative density is 1.06, spraying is dry, 175 ℃ of the inlet temperature of spray dryer, 85 ℃ of leaving air temps, be ground into subsequently powder, make dried cream powder;

Step 2: in the dried cream powder obtaining, add with respect to the cane sugar powder of 0.3 times of dried cream powder quality and the dextrin of 0.1 times, granulation, in 50 ℃ dry, obtain granule.

 

Described Chinese medicine is decocted in use decoction and is taken, and 1 dose of every day, decocting takes at twice, within 1 month, is a course for the treatment of; When this Chinese medicine composition is pill, capsule or while using containing tablet, tablet, granule, three times on the one 1 month is a course for the treatment of; When this Chinese medicine composition is spray use, 3-5 time on the one 1 month is a course for the treatment of.

 

Toxicity test:

Acute toxicity test: 60 of application NIH mices, SPF level, male and female half and half, body weight 17～24g, carries out acute toxicity test.Mice is divided into two groups at random, and 20 every group, matched group and administration group, test front fasting 12 hours; The granule of embodiments of the invention 3 preparations is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 28.7 crude drugs/kg), matched group gives equivalent normal saline, administration in a day 2 times, delivery time 6 hours, after administration, Continuous Observation is 14 days, and record mice toxic reaction and death toll.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Mice oral administration gavage granule LD50>28.7 of the present invention crude drug/kg, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention is 4.6g crude drug/day/people, becomes body weight for humans in 60KG, and average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight take 21g) oral administration gavage Chinese medicine of the present invention is quantity 745 times.Therefore the granule acute toxicity of the embodiment of the present invention 3 is low, clinical drug safety.

 

Long term toxicity test: by the spray of the embodiment of the present invention 1 to mice by 6.43,15.72 and 16 weeks (1.0ml/100g body weight of 36.41g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: Chinese medicine preparation of the present invention all has no significant effect indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine preparation of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.

 

Long term toxicity test: by the embodiment of the present invention 2 containing tablet to mice by 6.43,15.72 and 16 weeks (1.0ml/100g body weight of 36.41g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: Chinese medicine preparation of the present invention all has no significant effect indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine preparation of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.

 

Clinical data:

Case selection: anthology Out-patient Department case 180 examples, age 45-69 year, male 110 examples, female's 70 examples, are divided into four groups at random, and four groups of difference not statistically significants (P > 0.05) have comparability.

Spray treatment group: 45 people, male 27 people, female 18 people.

Contain tablet treatment group: 45 people, male 28 people, female 17 people.

Granules in Treating group: 45 people, male 27 people, female 18 people.

Western medicine group: 45 people, male 28 people, female 17 people.

Diagnostic criteria:

Western medicine diagnose standard is worked out with reference in November, 1979 whole nation chronic bronchitis clinical speciality meeting revised standard related content:

1. take cough, cough up phlegm as cardinal symptom or with panting, annual morbidity continues to reach 3 months, shows effect continuously more than 2 years.

2. get rid of that pulmonary tuberculosis, pneumoconiosis, pulmonary abscess, bronchial asthma, bronchiectasis, cardiac insufficiency, chronic cacorhinia etc. have cough, the other diseases of the symptom of coughing up phlegm, pant.

The traditional Chinese medical science disease Standardization of diagnosis and curative effect related content of tcm diagnosis standard State Administration of Traditional Chinese Medicine issue in 1994 is worked out.Primary symptom: heavy cough, heavy day of night is light, and the glutinous amount of expectorant is many.Inferior disease: weak limb weight, face is impractical, indigestion and loss of appetite abdominal distention, loose stool, light red tongue is fat, and there is indentation on limit, and tongue is greasy in vain, relaxed and soft pulse or cunning.

Allly meet above-mentioned clinical criteria and be diagnosed as chronic bronchitis, Chinese medical discrimination meets phlegm-damp and violates pulmonary type.

 

Therapeutic Method:

Spray treatment group: using the spray of the embodiment of the present invention 1 preparation, every day 3 times, 1 month is 1 course for the treatment of.

Contain tablet treatment group: take the tablet that contains of the embodiment of the present invention 2 preparations, every day 3 times, each 41 month is 1 course for the treatment of.

Granules in Treating group: take the granule of the embodiment of the present invention 3 preparations, every day 3 times, each 1 bag, 1 month is 1 course for the treatment of.

Western medicine group: the each 0.1g of oral aminophylline sheet, every day 3 times; Bromine second new film, each 16 mg, every day 3 times.Have antibiotic indication person to add cefalexin capsule, each 0.5 g, every day 4 times, 1 month is 1 course for the treatment of.

Efficacy assessment standard:

(1) clinic control: cough, expectorant, Chuan Ji pulmonary toot the sound of roaring returns to level before acute attack, other objective determination index normals.

(2) effective: cough, expectorant, Chuan Ji pulmonary wheezing sound significantly alleviates, but do not return to level before acute attack, other objective determination indexs are obviously improved.

(3) effective: cough, expectorant, Chuan Ji pulmonary wheezing sound has and alleviate, but degree is not remarkable, other objective determination indexs are improved.

(4) invalid: cough, expectorant, Chuan Ji pulmonary wheezing sound is without improving or increasing the weight of, and do not return to yet outbreak level in 1 month, other objective determination indexs have no to be improved or counter increasing the weight of.

Therapeutic outcome:

Referring to table 1 and table 2, as can be seen from Table 1, adopt treatment by Chinese herbs phlegm-damp of the present invention to violate pulmonary type chronic bronchitis, with respect to Western medicine, on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt treatment by Chinese herbs phlegm-damp of the present invention to violate pulmonary type chronic bronchitis, with respect to Western medicine, treating significantly shortening on the course for the treatment of.

Four groups, table 1 is treated respectively Clinical efficacy comparison example after 30 days

Group	Number of cases	Clinic control	Effective	Effectively	Invalid	Total effective rate
							Spray treatment group	45	19	13	13	0	100%
Containing tablet treatment group	45	21	12	12	0	100%
							Granules in Treating group	45	22	14	9	0	100%
Western medicine group	45	9	10	17	9	80%

Four groups, table 2 is treated respectively clinic control and effective number and time comparative example (%) after 30 days

Group	Number of cases	1-10 days	11-20 days	21-30 days
					Spray treatment group	32	9(28.1%)	14(43.8%)	9(28.1%)
Containing tablet treatment group	33	10(30.3%)	14(42.4%)	9(27.3%)
					Granules in Treating group	36	11(30.6%)	16(44.4%)	9(25.0%)
Western medicine group	19	4(21.1%)	7(36.8%)	8(42.1 %)

Known according to the clinical statistics in above table, that Chinese medicine provided by the invention has is rapid-action, effective percentage is high, determined curative effect, safe, the advantage that has no side effect; Simultaneously to spray treatment group clinic control and 32 effective examples, containing tablet treatment group clinic control and 33 effective examples, Granules in Treating group clinic control and 36 effective examples, and western medicine group clinic control and 19 effective routine patients follow up a case by regular visits to 1 year, result statistics:

Spray treatment group is cured and 32 effective examples, 9 example nothing recurrences of clinic control, and 1 case relapsed in 14 effective routine patients, relapse rate is 3.1%;

Containing tablet treatment group, cure and 33 effective examples, 10 example nothing recurrences of clinic control, 1 case relapsed in 14 effective routine patients, relapse rate is 3.0%;

Capsule treatment group is cured and 36 effective examples, 11 example nothing recurrences of clinic control, and 1 case relapsed in 16 effective routine patients, relapse rate is 2.8%;

Western medicine group is cured and 19 effective routine patients, and 4 examples of clinic control, without recurrence, recur 4 examples in 7 effective routine patients, and relapse rate is 21.1%.

Model case:

Patient Zhao, female, 61 years old, on November 10th, 2012 was medical, and recurrent cough March, readme suffers with chronic bronchitis 5 years.This morbidity has been suffered from cold because it is cold, plays cough with copious phlegm morning, and the glutinous amount of expectorant is many; After movable, cough increases the weight of, and heavy day of night is light, and pallor body is thin, weak limb weight, and face is impractical, companion's poor appetite, hyperhidrosis, drowsiness after meal, light red tongue is fat indentation, and tongue is greasy in vain, relaxed and soft pulse.Easy catching a cold usually.There is dry moist rale in auscultation base of lung portion.Chest X line shows: two lung bottom textures increase thick.Western medicine diagnose: chronic bronchitis, tcm diagnosis: phlegm-damp is violated pulmonary type.Take the granule of Chinese medicine preparation embodiment 3 of the present invention, every day 3 times, each 1 bag, after 5 days, cough symptom obviously alleviates, and within 15 days, substantially disappears afterwards.But after activity, still have cough, play amount of expectoration morning and obviously reduce.After 1 month, be almost recovered, clinic control, advises warming, follows up a case by regular visits to not recurrence in a year.

                                     

The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims (9)

1. treat the Chinese medicine that phlegm-damp is violated pulmonary type chronic bronchitis for one kind, it is characterized in that, comprise following raw medicinal material: Rhizoma Atractylodis, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Semen Raphani, fevervine, the Rhizoma Pinelliae, Rhizoma Arisaematis, Fructus Gleditsia, Rhizoma Cynanchi Stauntonii, Radix Platycodonis, Semen Armeniacae Amarum, Flos Farfarae, Folium Eriobotryae, Semen Ginkgo, Radix Physochlainae, Fructus Momordicae, Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Fructus Hippophae, Poria, Semen Coicis, Herba Gnaphalii uliginosi, Parmelia saxatilis Ach., Herba Inulae, Caulis Bambusae In Taenia, Herba Rorippae, Radix Ligulariae Dentatae, Indigo Naturalis, Radix Sophorae Viciifoliae and Radix Glycyrrhizae.

2. Chinese medicine according to claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Rhizoma Atractylodis 20-34 part, Cortex Magnoliae Officinalis 27-42 part, Pericarpium Citri Reticulatae 14-32 part, Semen Raphani 23-39 part, fevervine 14-30 part, Rhizoma Pinelliae 3-8 part, Rhizoma Arisaematis 4-9 part, Fructus Gleditsia 5-10 part, Rhizoma Cynanchi Stauntonii 17-35 part, Radix Platycodonis 22-36 part, Semen Armeniacae Amarum 5-11 part, Flos Farfarae 15-33 part, Folium Eriobotryae 10-25 part, Semen Ginkgo 4-10 part, Radix Physochlainae 3-9 part, Fructus Momordicae 18-31 part, Radix Pseudostellariae 11-27 part, Rhizoma Atractylodis Macrocephalae 16-37 part, Rhizoma Dioscoreae 15-27 part, Radix Et Caulis Acanthopanacis Senticosi 19-34 part, Fructus Hippophae 20-34 part, Poria 13-32 part, Semen Coicis 23-38 part, Herba Gnaphalii uliginosi 12-28 part, Parmelia saxatilis Ach. 12-27 part, Herba Inulae 13-30 part, Caulis Bambusae In Taenia 24-37 part, Herba Rorippae 19-33 part, Radix Ligulariae Dentatae 6-19 part, Indigo Naturalis 26-39 part, Radix Sophorae Viciifoliae 21-33 part and Radix Glycyrrhizae 27-42 part.

3. Chinese medicine according to claim 1 and 2, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Rhizoma Atractylodis 21-32 part, Cortex Magnoliae Officinalis 27-40 part, Pericarpium Citri Reticulatae 16-30 part, Semen Raphani 25-35 part, fevervine 16-28 part, Rhizoma Pinelliae 3-6 part, Rhizoma Arisaematis 4-7 part, Fructus Gleditsia 5-8 part, Rhizoma Cynanchi Stauntonii 19-33 part, Radix Platycodonis 24-32 part, Semen Armeniacae Amarum 5-9 part, Flos Farfarae 17-31 part, Folium Eriobotryae 12-22 part, Semen Ginkgo 4-8 part, Radix Physochlainae 3-7 part, Fructus Momordicae 18-28 part, Radix Pseudostellariae 13-25 part, Rhizoma Atractylodis Macrocephalae 18-32 part, Rhizoma Dioscoreae 16-26 part, Radix Et Caulis Acanthopanacis Senticosi 20-30 part, Fructus Hippophae 21-29 part, Poria 15-30 part, Semen Coicis 25-35 part, Herba Gnaphalii uliginosi 14-26 part, Parmelia saxatilis Ach. 16-22 part, Herba Inulae 13-27 part, Caulis Bambusae In Taenia 24-32 part, Herba Rorippae 19-29 part, Radix Ligulariae Dentatae 6-15 part, Indigo Naturalis 28-37 part, Radix Sophorae Viciifoliae 24-32 part and Radix Glycyrrhizae 29-40 part.

4. according to the arbitrary described Chinese medicine of claim 1-3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 21 parts of Rhizoma Atractylodis, 35 parts of Cortex Magnoliae Officinalis, 24 parts of Pericarpium Citri Reticulataes, 29 parts of Semen Raphanis, 16 parts of fevervines, 6 parts of the Rhizoma Pinelliaes, 4 parts of Rhizoma Arisaematiss, 8 parts, Fructus Gleditsia, 19 parts of Rhizoma Cynanchi Stauntoniis, 30 parts of Radix Platycodoniss, 5 parts of Semen Armeniacae Amarums, 19 parts of Flos Farfaraees, 12 parts of Folium Eriobotryaes, 8 parts of Semen Ginkgoes, 3 parts of Radix Physochlainae, 28 parts of Fructus Momordicaes, join very much 13 parts, 23 parts of the Rhizoma Atractylodis Macrocephalaes, 16 parts of Rhizoma Dioscoreaes, 26 parts of Radix Et Caulis Acanthopanacis Senticosis, 28 parts of Fructus Hippophaes, 30 parts, Poria, 35 parts of Semen Coiciss, 17 parts of Herba Gnaphalii uliginosi, 22 parts of Parmelia saxatilis Ach., 15 parts of Herba Inulae, 32 parts of Caulis Bambusae In Taenia, 23 parts of Herba Rorippae, 6 parts of Radix Ligulariae Dentataes, 35 parts of Indigo Naturaliss, 38 parts, 32 parts of Radix Sophorae Viciifoliae and Radix Glycyrrhizae.

5. according to the arbitrary described Chinese medicine of claim 1-3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 32 parts of Rhizoma Atractylodis, 40 parts of Cortex Magnoliae Officinalis, 16 parts of Pericarpium Citri Reticulataes, 35 parts of Semen Raphanis, 28 parts of fevervines, 4 parts of the Rhizoma Pinelliaes, 5 parts of Rhizoma Arisaematiss, 6 parts, Fructus Gleditsia, 33 parts of Rhizoma Cynanchi Stauntoniis, 32 parts of Radix Platycodoniss, 6 parts of Semen Armeniacae Amarums, 31 parts of Flos Farfaraees, 22 parts of Folium Eriobotryaes, 5 parts of Semen Ginkgoes, 4 parts of Radix Physochlainae, 18 parts of Fructus Momordicaes, 25 parts of Radix Pseudostellariaes, 32 parts of the Rhizoma Atractylodis Macrocephalaes, 18 parts of Rhizoma Dioscoreaes, 20 parts of Radix Et Caulis Acanthopanacis Senticosis, 21 parts of Fructus Hippophaes, 27 parts, Poria, 25 parts of Semen Coiciss, 26 parts of Herba Gnaphalii uliginosi, 19 parts of Parmelia saxatilis Ach., 27 parts of Herba Inulae, 24 parts of Caulis Bambusae In Taenia, 29 parts of Herba Rorippae, 15 parts of Radix Ligulariae Dentataes, 37 parts of Indigo Naturaliss, 40 parts, 24 parts of Radix Sophorae Viciifoliae and Radix Glycyrrhizae.

6. according to the arbitrary described Chinese medicine of claim 1-3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 28 parts of Rhizoma Atractylodis, 27 parts of Cortex Magnoliae Officinalis, 30 parts of Pericarpium Citri Reticulataes, 25 parts of Semen Raphanis, 23 parts of fevervines, 3 parts of the Rhizoma Pinelliaes, 7 parts of Rhizoma Arisaematiss, 5 parts, Fructus Gleditsia, 29 parts of Rhizoma Cynanchi Stauntoniis, 24 parts of Radix Platycodoniss, 9 parts of Semen Armeniacae Amarums, 17 parts of Flos Farfaraees, 16 parts of Folium Eriobotryaes, 4 parts of Semen Ginkgoes, 7 parts of Radix Physochlainae, 23 parts of Fructus Momordicaes, 20 parts of Radix Pseudostellariaes, 18 parts of the Rhizoma Atractylodis Macrocephalaes, 26 parts of Rhizoma Dioscoreaes, 30 parts of Radix Et Caulis Acanthopanacis Senticosis, 29 parts of Fructus Hippophaes, 15 parts, Poria, 33 parts of Semen Coiciss, 14 parts of Herba Gnaphalii uliginosi, 16 parts of Parmelia saxatilis Ach., 13 parts of Herba Inulae, 31 parts of Caulis Bambusae In Taenia, 19 parts of Herba Rorippae, 12 parts of Radix Ligulariae Dentataes, 28 parts of Indigo Naturaliss, 29 parts, 30 parts of Radix Sophorae Viciifoliae and Radix Glycyrrhizae.

7. according to the arbitrary described Chinese medicine of claim 1-6, it is characterized in that, when the dosage form of described Chinese medicine is spray, its preparation method comprises the following steps:

A, in described ratio, take all raw medicinal materials, add the water soaking 3-10 hour doubly with respect to the mixture quality 3-5 obtaining, after intense fire boils, using slow fire instead, to decoct slowly the 30-50 minute dosage to medicinal liquid be 100-300ml, decoct 3 times, merge decoction liquor and filter, filtrate is heated to obtain extractum 1, and medicinal residues are standby;

B, the medicinal residues of step a are added to 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid,, 80-160 order filters, getting the 6000-10000 rev/min of supernatant after centrifugal, is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, 1.35 extractum 2 when ultrafiltrate concentrating under reduced pressure obtains relative density and is 80 ℃;

C, extractum 1 and extractum 2 is mixed, thin up obtains spray.

8. according to the arbitrary described Chinese medicine of claim 1-6, it is characterized in that, the dosage form of described Chinese medicine is that while containing tablet, its preparation method comprises the following steps:

The first step, ratio described in Rhizoma Atractylodis, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Semen Raphani, fevervine, the Rhizoma Pinelliae, Rhizoma Arisaematis, Fructus Gleditsia, Rhizoma Cynanchi Stauntonii and Radix Platycodonis is mixed, use the soak with ethanol with respect to the determining alcohol 90%～95% of 4～6 times of the mixture quality obtaining, reflux was extracted after 2～4 hours, filtered; Filtering residue is used to the soak with ethanol with respect to the determining alcohol 85%～95% of 2～4 times of the mixture quality obtaining again, and reflux was extracted after 1～2 hour, filtered; Merge filtrate twice, decompression recycling ethanol to be concentrated into liquor strength be 0.8～1.2g crude drug/mL, utilize twice of the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, with the determining alcohol of 3 times of resin column volumes, be 90%～95% ethanol elution again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;

Second step, Semen Armeniacae Amarum, Flos Farfarae, Folium Eriobotryae, Semen Ginkgo, Radix Physochlainae, Fructus Momordicae and Radix Pseudostellariae are mixed in described ratio, the alcohol heating reflux adding with respect to the determining alcohol 85%～95% of 3～5 times of the mixture quality obtaining extracts 2 times, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 ℃ under the condition of 60 ℃～70 ℃, relative density is 1.20～1.23, is dried to powder by the mastic after concentrated with spray dryer;

The 3rd step, mixes surplus stock medical material in described ratio, add the water soaking of 2～5 times with respect to the mixture quality obtaining, and heating decocts 2～4 hours, filters; Filtering residue is used to the water soaking of 1～3 times with respect to the mixture quality obtaining again, and heating decocts 1～2 hour, filters; Merge filtrate twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;

The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, further add with respect to the carboxymethyl starch sodium of 0.05～0.1 times of the mixture quality obtaining, the microcrystalline Cellulose of 0.05～0.1 times, mix, granulate, after being dried, add the magnesium stearate with respect to 0.01～0.05 times of the mixture quality obtaining, then with decompressor by granule compacting in flakes, obtain containing tablet.

9. according to the arbitrary described Chinese medicine of claim 1-6, it is characterized in that, when the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:

Step 1: described raw medicinal material is mixed in described ratio, add the ethanol that the determining alcohol with respect to 4～8 times, mixture is 85%～95%, be heated to boiling reflux 3～5 hours, filter, adopt percolation with the speed of 1～2ml per minute percolation slowly, collect percolate, the mastic that while being evaporated to 50～60 ℃ subsequently under vacuum 0.06～0.09Mpa, relative density is 1.04～1.10, spraying is dry, 160～175 ℃ of the inlet temperature of spray dryer, 80～85 ℃ of leaving air temps, be ground into subsequently powder, make dried cream powder;

Step 2: in the dried cream powder obtaining, add with respect to the cane sugar powder of 0.2～0.4 times of dried cream powder quality and the dextrin of 0.1～0.2 times, granulation, in 40～50 ℃ dry, obtain granule.