CN105412679A - Traditional Chinese medicine preparation for treating lung abscess and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating lung abscess and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention provides a traditional Chinese medicine preparation for treating a lung abscess and a preparation method thereof. The traditional Chinese medicine preparation is prepared from herb of flaccid aster, herb of rosette thistle, fructus hippophae, stems and leaves of Japanese cryptotaenia cryptotaenia japonica Hassk., Karka reeds, all-grass of hooker cremanthodium, shrubalthea roots, reed leaves, herb of sensitiveplant-like senna, roots of rose cowwheat, lycopus lucidus Turcz., roots of evans begonia, rhizome of twoleaf platanthera, sri lanka pouzolzia herb, polygonum barbatum Linn., roots of intermediate Peashrub., herb of threeflower bluebeard, leaves of common perilla, thesium longifolium Turcz. ex Ledeb., radices primulae and roots of lineate supplejack. The traditional Chinese medicine preparation for treating the lung abscess and the preparation method thereof have the advantages that the traditional Chinese medicine preparation for treating the lung abscess is safe and convenient to use, good in treatment effect and free of toxic and side effects and adverse reactions, and the preparation technology is simple.
Description
Technical field
The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of Chinese medicine preparation for the treatment of pulmonary abscess and preparation method thereof.
Background technology
Pulmonary abscess is the lung tissue purulent lesion caused by Different types of etiopathogenises.Early stage is suppurative inflammation, then downright bad formation abscess.Can be divided into primary pulmonary abscess and secondary pulmonary abscess, the former is how relevant with suction, and be apt to occur in lobi inferior dorsal segment and upper leaf back segment, right side is more more common than left side, also known as aspiration pulmonary abscess; The hematogenous pulmonary abscess that secondary pulmonary abscess causes with septicemia is more common, also can derive from the direct invasion of adjacent organ, as liver ameba or subphrenic abscess can invade pulmonary, causes pulmonary abscess.The course of disease was more than 3 months, and protracted course of disease person is chronic pulmonary abscess.Clinical with high heat, cough, cough up a large amount of purulence or stink expectorant for feature.Since antibiotic is widely used in pneumonia infection, pulmonary abscess sickness rate obviously reduces.The antibacterial causing acute pulmonary abscess to infect is general upper respiratory tract, oral cavity often deposit bacterium.Normal is mixed infection, comprises the Gram's staining of aerobic, amphimicrobian and anaerobism positive in negative coccus and bacillus, as staphylococcus, streptococcus, streptococcus pneumoniae, pneumobacillus etc.; Main anaerobe has peptostreptococcus, dyspepsiacoccus, karyosome fusiform bacilarmature, Bacteroides, Wei Rong flourish coccus, Microaerophilic etc.When the defense function of human body or respiratory tract is damaged, pathogen can enter alveolar breeding and cause a disease.
Have in motherland's medical science " case of Liu Xuan tetra-case ring brookweed halls " ancient books and records carry " disease of lung abscess, all because evil stasis blocking is in lung network, is accumulate heat-dissipating for a long time, is evaporated into pus." a variety of causes causes the strongly fragrant lung of pathogenic heat, steams liquid and becomes expectorant, evilly stops up lung network, QI and blood blocks, and causes expectorant heat and tie mutually with blood stasis, and blood loses meat corruption, damage of pulmonary collateral, and the diabrosis of pus infections leaks and forms carbuncle.Its Pathologic process, with PD, ebb and flow between pathogen and vital QI, can show as the initial stage, becomes the carbuncle phase, bursts the stage such as pus phase and convalescent period.Lung abscess from the beginning of, how because wind heat attacks lung, or affection by exopathogenic cold-wind, lung qi closes strongly fragrant, with the passing of time heat-transformation; Then accumulatiorn of pathogenic heat in the lung, in stagnant heat, knot, accumulates and leads to carbuncle.Pyretic toxicity fills Sheng, and the rotten blood of meat loses, and causes pus of carbuncle diabrosis, and coughs and tell a large amount of stench purulent sputum; Or hinder venation because pyretic toxicity consumes, and cough vomiting bloody pus.In the course of disease later stage, purulent sputum is discharged gradually to the greatest extent, evil poison oneself ease up and, also see consumption wound with seasonal epidemic pathogens the moon, therefore the pathological change of common QI consumed the moon wound, form the disease of simulataneous insufficiency and excessive; If after septicopyemia ulceration, not to the greatest extent, deficient vital QI leading to lingering of pathogen, then protracted inflammation repeatedly, and with the passing of time difficult, the performance of impairment of both QI and YIN is more outstanding for evil poison.
Summary of the invention
Technical problem to be solved by this invention is, utilizes the theory of Chinese medical science that China is traditional, provides a kind of determined curative effect and Chinese medicine preparation of the little treatment pulmonary abscess of toxic action and preparation method thereof.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of pulmonary abscess, described Chinese medicine preparation comprises following raw medicinal material: Herba Asteris Flaccidi, Herba cirsii esculenti, Fructus Hippophae, Caulis et folium cryptotaeniae japonicae, Phragmites karka (Retz.) Trin., Herba Cremanthodii hookerii, Radix Hibisci, Folium Phragmitis, Herba Cassiae Mimosoidis, mountain trailing plants, Rhizoma Lycopi Lucidi, Radix Bischofiae Javanicae, Rhizoma Platantherae Chloranthae, Herba Pouzolziae Zeylanicae, Herba Polygoni Barbati, Radix Caraganae intermediae, Herba Caryopteridis Terniflorae, Folium Perillae Frutescentis, Herba Thesii Longifolii, Radix Primulae sieboldii and Radix berchemiae lineatae.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: Herba Asteris Flaccidi 25 ~ 35 parts, Herba cirsii esculenti 10 ~ 20 parts, Fructus Hippophae 15 ~ 25 parts, Caulis et folium cryptotaeniae japonicae 20 ~ 30 parts, Phragmites karka (Retz.) Trin. 5 ~ 15 parts, Herba Cremanthodii hookerii 25 ~ 35 parts, Radix Hibisci 10 ~ 20 parts, Folium Phragmitis 30 ~ 40 parts, Herba Cassiae Mimosoidis 15 ~ 25 parts, mountain trailing plants 20 ~ 30 parts, Rhizoma Lycopi Lucidi 15 ~ 25 parts, Radix Bischofiae Javanicae 20 ~ 30 parts, Rhizoma Platantherae Chloranthae 10 ~ 20 parts, Herba Pouzolziae Zeylanicae 25 ~ 35 parts, Herba Polygoni Barbati 15 ~ 25 parts, Radix Caraganae intermediae 30 ~ 40 parts, Herba Caryopteridis Terniflorae 5 ~ 15 parts, Folium Perillae Frutescentis 25 ~ 35 parts, Herba Thesii Longifolii 10 ~ 20 parts, Radix Primulae sieboldii 15 ~ 25 parts and Radix berchemiae lineatae 20 ~ 30 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also more preferably: Herba Asteris Flaccidi 25 ~ 30 parts, Herba cirsii esculenti 15 ~ 20 parts, Fructus Hippophae 20 ~ 25 parts, Caulis et folium cryptotaeniae japonicae 25 ~ 30 parts, Phragmites karka (Retz.) Trin. 10 ~ 15 parts, Herba Cremanthodii hookerii 30 ~ 35 parts, Radix Hibisci 15 ~ 20 parts, Folium Phragmitis 35 ~ 40 parts, Herba Cassiae Mimosoidis 15 ~ 20 parts, mountain trailing plants 25 ~ 30 parts, Rhizoma Lycopi Lucidi 15 ~ 20 parts, Radix Bischofiae Javanicae 25 ~ 30 parts, Rhizoma Platantherae Chloranthae 15 ~ 20 parts, Herba Pouzolziae Zeylanicae 30 ~ 35 parts, Herba Polygoni Barbati 15 ~ 20 parts, Radix Caraganae intermediae 35 ~ 40 parts, Herba Caryopteridis Terniflorae 5 ~ 10 parts, Folium Perillae Frutescentis 25 ~ 30 parts, Herba Thesii Longifolii 10 ~ 15 parts, Radix Primulae sieboldii 20 ~ 25 parts and Radix berchemiae lineatae 25 ~ 30 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation also can more preferably: Herba Asteris Flaccidi 26 parts, Herba cirsii esculenti 19 parts, Fructus Hippophae 21 parts, Caulis et folium cryptotaeniae japonicae 29 parts, Phragmites karka (Retz.) Trin. 12 parts, Herba Cremanthodii hookerii 35 parts, Radix Hibisci 16 parts, Folium Phragmitis 38 parts, Herba Cassiae Mimosoidis 16 parts, mountain trailing plants 29 parts, Rhizoma Lycopi Lucidi 19 parts, Radix Bischofiae Javanicae 26 parts, Rhizoma Platantherae Chloranthae 19 parts, Herba Pouzolziae Zeylanicae 31 parts, Herba Polygoni Barbati 19 parts, Radix Caraganae intermediae 36 parts, Herba Caryopteridis Terniflorae 10 parts, Folium Perillae Frutescentis 26 parts, Herba Thesii Longifolii 15 parts, Radix Primulae sieboldii 21 parts and Radix berchemiae lineatae 28 parts.
When the dosage form of described Chinese medicine preparation is granule, its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
When the dosage form of described Chinese medicine preparation is syrup, its preparation method comprises the following steps:
The first step, by Herba Asteris Flaccidi, Herba cirsii esculenti, Fructus Hippophae, Caulis et folium cryptotaeniae japonicae, Phragmites karka (Retz.) Trin. and Herba Cremanthodii hookerii mix in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 80% ~ 90%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 2 hours ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder,
Second step, Herba Pouzolziae Zeylanicae, Herba Polygoni Barbati, Radix Caraganae intermediae, Radix Primulae sieboldii and Radix berchemiae lineatae are mixed in described ratio, be ground into powder, be that the ethanol of 85% ~ 95% is as solvent with determining alcohol, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.25 ~ 1.27, dry with spray dryer, be ground into 100 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 3 ~ 5 times of second step mixture quality;
3rd step, surplus stock medical material is mixed in described ratio, add relative to mixture 4 ~ 6 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;
4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 3 ~ 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 35 ~ 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.3%, paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05%.
Beneficial effect of the present invention: the Chinese medicine preparation that pulmonary abscess of the present invention uses is safe and convenient to use, and therapeutic effect is good, has no side effect, and has no adverse reaction, and preparation technology is simple.
Detailed description of the invention
The invention provides a kind of Chinese medicine preparation for the treatment of pulmonary abscess, Chinese medicine preparation comprises following raw medicinal material: Herba Asteris Flaccidi, Herba cirsii esculenti, Fructus Hippophae, Caulis et folium cryptotaeniae japonicae, Phragmites karka (Retz.) Trin., Herba Cremanthodii hookerii, Radix Hibisci, Folium Phragmitis, Herba Cassiae Mimosoidis, mountain trailing plants, Rhizoma Lycopi Lucidi, Radix Bischofiae Javanicae, Rhizoma Platantherae Chloranthae, Herba Pouzolziae Zeylanicae, Herba Polygoni Barbati, Radix Caraganae intermediae, Herba Caryopteridis Terniflorae, Folium Perillae Frutescentis, Herba Thesii Longifolii, Radix Primulae sieboldii and Radix berchemiae lineatae.
The pharmacology of various raw medicinal material is as follows:
Herba Asteris Flaccidi: [another name] Herba Saniculae lamelligerae.[source] medical material Ji Yuan: for feverfew withers the herb of soft Radix Asteris.[nature and flavor] bitter in the mouth; Micro-pungent; Cool in nature.[function cures mainly] clearing and antitussive.Main cough due to lung-heat; Lung abscess; Pertussis.[extracts] " China's book on Chinese herbal medicine "
Herba cirsii esculenti: [another name] eats Ji.[source] medical material Ji Yuan: be the herb of feverfew Herba cirsii esculenti.[nature and flavor] sweet in the mouth; Cool in nature.[function cures mainly] dissipating blood stasis for subsidence of swelling; Evacuation of pus; Poison holding; Hemostasis.Main pulmonary abscess; Bronchitis; Sore and toxic; Spit blood; Spitting of blood; Hematuria; Metrorrhagia.[extracts] " China's book on Chinese herbal medicine "
Fructus Hippophae: [another name] fructus hippophae, acid thorn, black thorn, vinegar willow.[source] this strain Mongols, Tibetan's conventional crude drugs.For the dry mature fruit of Elaeangnaceae hippophae plant Fructus Hippophae.[nature and flavor] are sour, puckery, temperature.[function cures mainly] eliminating phlegm and stopping cough, relieving dyspepsia, promoting blood circulation to remove blood stasis.For cough with copious phlegm, dyspepsia, abdominal pain due to retention of food, blood stasis amenorrhea, falls and flutters congestive edema.[extracts] " Chinese Pharmacopoeia "
Caulis et folium cryptotaeniae japonicae: [another name] is when field, wild hollyhock, Herba ranunculi siebolkii, Herba Apii, Herba monochasmatis, duck sole.[source] medical material Ji Yuan: be the stem and leaf of samphire Caulis et folium cryptotaeniae japonicae.[nature and flavor] acrid in the mouth; Bitter; Property is put down.[function cures mainly] dispelling wind stopping cough; Eliminating damp, detoxifying; Blood-activating analgetic.Main cold cough; Lung abscess; Drench pain; Hernia; Menoxenia; Acute toothache; Cataract; Carbuncle skin ulcer swells; Skin pruritus; Treating swelling and pain by traumatic injury; Snake bite and insect sting.[each discussion] 1. " classifies herbal ": control white pouring, detumescence poison, regulating menstruation, annealing.2. " Traditional Chinese Medicine in Sichuan will ": antiinflammatory is regulated the flow of vital energy.Control weak tired, bladder hernia, five types of stranguria urine retention and innominate toxic swelling.3. " conventional Chinese herbal medicine formula ": antibacterial, antiinflammatory, removing toxic substances, hemostasis, pain relieving.[extracts] " China's book on Chinese herbal medicine "
Phragmites karka (Retz.) Trin.: [another name] Caulis Entadae.[source] medical material Ji Yuan: for the rhizome of reed opened by grass card.[nature and flavor] are bitter; Cold.[function cures mainly] heat-clearing and toxic substances removing; The quiet detumescence of profit.Main calentura is gone mad; Lung abscess; Dysentery; Yellowish or reddish urine; Oedema due to nephritis.[each discussion] " Nanning City's medicine will ": heat clearing away, diuresis.Control large heat symptom-complex to go mad and diarrhea of heat type.[extracts] " China's book on Chinese herbal medicine "
Herba Cremanthodii hookerii: [source] medical material Ji Yuan: for feverfew hangs one's head the herb of chrysanthemum.[nature and flavor] bitter in the mouth; Pungent; Property is put down.[function cures mainly] preventing phlegm from forming and stopping coughing.Main phlegm dyspnea cough; Lung abscess.[extracts] " China's book on Chinese herbal medicine "
Radix Hibisci: [another name] hedge grass roots.[source] medical material Ji Yuan: be the root of Malvaceae plant Hibiscus syriacus L..[nature and flavor] are sweet; Cool.[return through] lung; Kidney; Large intestine channel.[function cures mainly] heat-clearing and toxic substances removing; Subduing inflammation.Main hemorrhoidal hamorrhage; Dysentery; Lung abscess; Intestinal carbuncle; Swelling and pain of hemorrhoid; Leucorrhea with red and white discharge; Scabies; Pulmonary tuberculosis.[each discussion] 1. " detailed outline " controls leucorrhea with red and white discharge, and swell and ache scabies, washes order and make bright, moisturize and invigorate blood circulation.2. " medical center bun is wanted ": control lung abscess, acute appendicitis, can be descending.3. " Nanning City's medicine will ": rhizome: clearing and antitussive.[extracts] " China's book on Chinese herbal medicine "
Folium Phragmitis: [another name] reed indocalamus.[source] medical material Ji Yuan: be the leaf of grass phragmites communis.[nature and flavor] are sweet; Cold.[return through] lung; Stomach warp.[function cures mainly] heat clearing away is warded off dirty; Hemostasis; Removing toxic substances.Main cholera leaf rushes down; Spit blood; Epistaxis; Lung abscess.[each discussion] 1. Compendium of Material Medica: control cholera vomiting, carbuncle.2. " beautiful Chinese catalpa medicine solution ": lung heat clearing preventing or arresting vomiting.Control back of the body cellulitis lung abscess.[extracts] " China's book on Chinese herbal medicine "
Herba Cassiae Mimosoidis: [another name] dream grass, fine and closely woven comb, wild Medulla Tetrapanacis, Sabina procumbens grass, Matteuccia struthiopteri, Herba Lactucae versicoloris grass.[source] medical material Ji Yuan: be the Herb of leguminous plant Herba Mimosae Pudicae Semen Cassiae.[nature and flavor] sweetness and bitterness; Flat; Nontoxic.[return through] liver; Kidney; Spleen; Stomach warp.[function cures mainly] heat-clearing and toxic substances removing, invigorating spleen to remove dampness, relieving constipation.Main jaundice, summer-heat is vomited and diarrhoea, infantile malnutrition, edema, dysuria, habitual constipation, furuncle carbuncle, venom.[each discussion] 1. " Nanning City's medicine will ": heat clearing away, helps digestion, and promotes the production of body fluid.Control infantile malnutrition, only excessive thirst.2. " Guangdong Chinese medicine ": control impairment caused by overstrain and amass the stasis of blood, endogenous cough.3. " Guizhou medical herbs ": clearing heat for detumescence, relieving stranguria by diuresis.[extracts] " China's book on Chinese herbal medicine "
Mountain trailing plants: [another name] ball rust grass.[source] medical material Ji Yuan: be the herb of goatweed Melampyrum roseum Maxim.[nature and flavor] bitter in the mouth; Cool in nature.[function cures mainly] heat-clearing and toxic substances removing.Main carbuncle pyogenic infections from tumour or sore; Lung abscess; Acute appendicitis.[each discussion] " Xinhua's book on Chinese herbal medicine outline ": herb has the function of heat-clearing and toxic substances removing.For carbuncle sore tumefacting virus.Root: make tea, has refrigerant effect.[extracts] " China's book on Chinese herbal medicine "
Rhizoma Lycopi Lucidi: [another name] Herba Lycopi root, Radix Pachyrhizi Erosi, Rhizoma Nelumbinis, non-irrigated Rhizoma Nelumbinis.[source] medical material Ji Yuan: be the rhizome of labiate Rhizoma Lycopi Lucidi and Mao Ye Rhizoma Lycopi Lucidi.[nature and flavor] sweet in the mouth; Pungent; Property is put down.[function cures mainly] removing stasis to stop bleeding; Supplementing QI to induce diuresis.Main epistaxis; Spit blood; Puerperal abdonimal pain; Jaundice; Friend swells; Leukorrhagia; The deficiency of vital energy is weak.[each discussion] 1. supplement to the Herbal: sharp nine orifices, promoting blood circulation, blood is controlled in evacuation of pus.2. " classify herbal ": gentlely to nourish blood, mend smart solid and gas, control the weak pallor of woman.[extracts] " China's book on Chinese herbal medicine "
Radix Bischofiae Javanicae: [another name] gold thread hoist, red white two balls, Radix Bischofiae Javanicae.[source] medical material Ji Yuan: be the root of Begoniaceae plant Flos Begoniae Evansianae.[nature and flavor] sour in the mouth; Puckery.[function cures mainly] blood stasis dispelling; Hemostasis; Clearing away heat-damp and promoting diuresis.Main traumatic injury; Spit blood, spit blood; Epistaxis; Knife injury is hemorrhage; Metrorrhagia; Blood stasis amenorrhea; Menoxenia; Leukorrhagia; Stranguria with turbid discharge; Dysentery; Stomachache; Laryngopharynx swelling and pain.[each discussion] 1. " Shaanxi Chinese herbal medicine ": promoting blood circulation to remove blood stasis, heat clearing away, hemostasis and pain-relieving.Control traumatic injury, spit blood, epistaxis, gastric ulcer, dysentery, lung abscess, metrorrhagia, leucorrhea, menoxenia.2. Jiangxi " medical herbs handbook ": circulation of qi promoting promoting the circulation of blood, reducing swelling and alleviating pain, spasmolytic, controls scrofula.[extracts] " China's book on Chinese herbal medicine "
Rhizoma Platantherae Chloranthae: [another name] salep, Serpentis ginseng.[source] medical material Ji Yuan: be the tuber of orchid two tip of a leaf lip orchid.[nature and flavor] are bitter; Flat.[return through] lung; Spleen channel.[function cures mainly] tonifying the lung stops flesh; Removing stasis to stop bleeding.Main pulmonary tuberculosis hemoptysis; Spit blood; Epistaxis; Wound; Burn and scald; Carbuncle.[each discussion] " Chinese herbal medicine is commonly used in Tibet ": tonifying the lung granulation promoting, removing stasis to stop bleeding.Control pulmonary tuberculosis hemoptysis, spit blood, epistaxis, wound, carbuncle, burn.[extracts] " China's book on Chinese herbal medicine "
Herba Pouzolziae Zeylanicae: [another name] dissipate, pus see disappear, Debregeasia orientalis C. J. Chen seedling, SHANSHEN, Oryza glutinosa hill covered with grass three eggplant, raw meat medicine.[source] medical material Ji Yuan: for contrayerva fog band root is very removed from office entirely.[nature and flavor] are sweet; Light; Cold in nature.[function cures mainly] heat-clearing and toxic substances removing; Clear swollen evacuation of pus; Relieving stranguria by diuresis.Main pyogenic skin infection and carbuncle-abscess; Acute mastitis; Acute toothache; Dysentery; Diarrhoea; Urine leaching pain; Nebulousurine.[each discussion] 1. " the south of Fujian Province traditional herbal medicine ": dew Pueraria lobota, and effect of drawing out the pus is very strong, no pus person hurriedly with it, in order to avoid increase pain.2. " south of the Five Ridges gather medicinal herbs record ": get stem and leaf and stir juice, apply skin ulcer cellulitis and burn, the evacuation of pus of Sweeling-eliminating medicine powder poison.Can nebulousurine be controlled again, dysentery due to damp-heat, get its root decoction.[extracts] " China's book on Chinese herbal medicine "
Herba Polygoni Barbati: [another name] smartweed, Herba Commelinae Bengalensis, red stalk grass, spinelet Herba Polygoni Barbati, Rhizoma et radix valerianae.[source] medical material Ji Yuan: be the herb of polygonaceae plant Herba Polygoni Barbati.[nature and flavor] are pungent; Warm in nature.[function cures mainly] heat-clearing and toxic substances removing; Evacuation of pus granulation promoting; Invigorate blood circulation; Rash.Main fever caused by exogenous pathogens; Throat moth; Chronic malaria; Dysentery; Have loose bowels; Carbuncle; Cellulitis; Fistula; Scrofula diabrosis is not held back, snake bite and insect sting; Traumatic injury; Rheumatic arthralgia; Measles does not lure.[each discussion] " register planted by Guangxi medicine ": detumescence, loose poison, controls dermatosis.[extracts] " China's book on Chinese herbal medicine "
Radix Caraganae intermediae: [source] medical material Ji Yuan: be the root of leguminous plant Caragana intermedia.[nature and flavor] are micro-pungent; Temperature.[return through] heart; Liver Channel.[function cures mainly] supplementing QI and nourishing YIN.Main dizziness, cardiopalmus, shortness of breath and fatigue, hypertension.[extracts] " China's book on Chinese herbal medicine "
Herba Caryopteridis Terniflorae: [another name] Flos Carthami Herba lamii barbati, wild mint, mountain volume lotus, wild catmint, yellow perverse bubble, wind and cold grass, Herba Anoectochili roxburghii.[source] medical material Ji Yuan: be the herb of dicotyledon medicine Verbenaceae three flower Herba caryopteridis nepetaefoliae.[nature and flavor] pungent micro-hardship; Flat.[return through] lung meridian.[function cures mainly] dispelling wind to relieve the exterior syndrome; Lung qi dispersing cough-relieving.Main flu; Cough; Pertussis; External oculopathy corneal nebula; Burn due to hot liquid or fire.[each discussion] be " Tian Bao book on Chinese herbal medicine " 1.: cold expelling relieves inflammation or internal heat, and controls all pains, external oculopathy corneal nebula, coughs as all.2. " conventional herbtherapy hands is deleted ": deliver cold expelling, lung qi dispersing cough-relieving.Control cough due to wind and cold.[extracts] " China's book on Chinese herbal medicine "
Folium Perillae Frutescentis: [another name] weak leaf.[source] medical material Ji Yuan: be the leaf of labiate common perilla.[nature and flavor] acrid in the mouth; Warm in nature.[return through] returns lung; Spleen channel.[function cures mainly] dispelling wind and ventilating the lung; Regulate the flow of vital energy and help digestion, solving toxin of fish and crab.Main cold; Cough and asthma; Gastral cavity abdominal distention is vexed; Accumulation of food in the stomach and intes tine due to indigestion; Vomit and diarrhoea; Cold-dysentery; Middle fish Eriocheir sinensis poison; Man's swelling of the vulva; Limb edema due to disorder of QI poison; Snake bite and insect sting.[each discussion] 1. " Japan hanako materia medica ": regulating QI, profit cardiopulmonary, longue skin, beneficial color, and disappear dyspepsia, only upper gas cough, and go bromhidrosis, deposited Serpentis stings.2. " Fujian traditional herbal medicine ": disappear cold air, only cold-dysentery, dispels the wind antipyretic, and anthelmintic is detoxified.[extracts] " China's book on Chinese herbal medicine "
Herba Thesii Longifolii: [another name] Kowloon grass, Herba Phyllanthi Urinariae, Jiu Xiancao, green coral, a pine.[source] medical material Ji Yuan: for Santalaceae plant comes into leaves Herba Thesii, dew post Herba Thesii, the herb of Thesium longifolium Hand.-Mazz. or Thesium refractum C. A. Meyer or root.[nature and flavor] are pungent; Micro-hardship; Cool in nature.[return through] lung; Liver; Spleen channel.[function cures mainly] induces sweat heat clearing away; Expelling wind and relieving convulsion.Main flu; Heatstroke; Infantile pneumonia; Infantile convulsion.[each discussion] " choosing of Yunnan Chinese herbal medicine ": induce sweat, heat clearing away.[extracts] " China's book on Chinese herbal medicine "
Radix Primulae sieboldii: [another name] wild Pemisetum flaccidum Griseb..[source] medical material Ji Yuan: be the root and rhizome of Ofthe Primulaceae primrose.[nature and flavor] are sweet; Property is put down.[function cures mainly] preventing phlegm from forming and stopping coughing.Main cough with asthma abundant expectoration.[each discussion] " Jilin Chinese herbal medicine ": relieving cough and resolving phlegm.Control phlegm dyspnea cough.[extracts] " China's book on Chinese herbal medicine "
Radix berchemiae lineatae: [another name] Canis familiaris L. foot profit, carry cloud grass, coal rattan, oolong root, black Herba Epigeneii fargesii.[source] medical material Ji Yuan: for Rhamnaceae plant iron is covered with gold leaf and the ratan of Herba Berchemiae leiocladae or root.[nature and flavor] are bitter; Micro-puckery; Flat.[return through] heart; Lung meridian.[function cures mainly] subduing swelling and detoxicating; Hemostatic analgesia; Expelling wind and removing dampness.Main carbuncle furunculosis; Cough spitting of blood; Digestive tract hemorrhage; Traumatic injury; Scald; Rheumatic ostalgia; Acute toothache.[each discussion] 1. " Fujian traditional herbal medicine ": wind-damp dispelling, removing toxic substances.Control Mus wart, hemorrhoid, proctoptosis, acute mastitis, rheumatalgia, pathogenic wind toxic multiple abscess.2. " south of the Five Ridges herbal ": can blood stasis dispelling.Control spitting of blood, hemoptysis.[extracts] " China's book on Chinese herbal medicine "
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: Herba Asteris Flaccidi 25 ~ 35 parts, Herba cirsii esculenti 10 ~ 20 parts, Fructus Hippophae 15 ~ 25 parts, Caulis et folium cryptotaeniae japonicae 20 ~ 30 parts, Phragmites karka (Retz.) Trin. 5 ~ 15 parts, Herba Cremanthodii hookerii 25 ~ 35 parts, Radix Hibisci 10 ~ 20 parts, Folium Phragmitis 30 ~ 40 parts, Herba Cassiae Mimosoidis 15 ~ 25 parts, mountain trailing plants 20 ~ 30 parts, Rhizoma Lycopi Lucidi 15 ~ 25 parts, Radix Bischofiae Javanicae 20 ~ 30 parts, Rhizoma Platantherae Chloranthae 10 ~ 20 parts, Herba Pouzolziae Zeylanicae 25 ~ 35 parts, Herba Polygoni Barbati 15 ~ 25 parts, Radix Caraganae intermediae 30 ~ 40 parts, Herba Caryopteridis Terniflorae 5 ~ 15 parts, Folium Perillae Frutescentis 25 ~ 35 parts, Herba Thesii Longifolii 10 ~ 20 parts, Radix Primulae sieboldii 15 ~ 25 parts and Radix berchemiae lineatae 20 ~ 30 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also more preferably: Herba Asteris Flaccidi 25 ~ 30 parts, Herba cirsii esculenti 15 ~ 20 parts, Fructus Hippophae 20 ~ 25 parts, Caulis et folium cryptotaeniae japonicae 25 ~ 30 parts, Phragmites karka (Retz.) Trin. 10 ~ 15 parts, Herba Cremanthodii hookerii 30 ~ 35 parts, Radix Hibisci 15 ~ 20 parts, Folium Phragmitis 35 ~ 40 parts, Herba Cassiae Mimosoidis 15 ~ 20 parts, mountain trailing plants 25 ~ 30 parts, Rhizoma Lycopi Lucidi 15 ~ 20 parts, Radix Bischofiae Javanicae 25 ~ 30 parts, Rhizoma Platantherae Chloranthae 15 ~ 20 parts, Herba Pouzolziae Zeylanicae 30 ~ 35 parts, Herba Polygoni Barbati 15 ~ 20 parts, Radix Caraganae intermediae 35 ~ 40 parts, Herba Caryopteridis Terniflorae 5 ~ 10 parts, Folium Perillae Frutescentis 25 ~ 30 parts, Herba Thesii Longifolii 10 ~ 15 parts, Radix Primulae sieboldii 20 ~ 25 parts and Radix berchemiae lineatae 25 ~ 30 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation also can more preferably: Herba Asteris Flaccidi 26 parts, Herba cirsii esculenti 19 parts, Fructus Hippophae 21 parts, Caulis et folium cryptotaeniae japonicae 29 parts, Phragmites karka (Retz.) Trin. 12 parts, Herba Cremanthodii hookerii 35 parts, Radix Hibisci 16 parts, Folium Phragmitis 38 parts, Herba Cassiae Mimosoidis 16 parts, mountain trailing plants 29 parts, Rhizoma Lycopi Lucidi 19 parts, Radix Bischofiae Javanicae 26 parts, Rhizoma Platantherae Chloranthae 19 parts, Herba Pouzolziae Zeylanicae 31 parts, Herba Polygoni Barbati 19 parts, Radix Caraganae intermediae 36 parts, Herba Caryopteridis Terniflorae 10 parts, Folium Perillae Frutescentis 26 parts, Herba Thesii Longifolii 15 parts, Radix Primulae sieboldii 21 parts and Radix berchemiae lineatae 28 parts.
When the dosage form of described Chinese medicine preparation is granule, it comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
When the dosage form of described Chinese medicine preparation is syrup, it comprises the following steps:
The first step, by Herba Asteris Flaccidi, Herba cirsii esculenti, Fructus Hippophae, Caulis et folium cryptotaeniae japonicae, Phragmites karka (Retz.) Trin. and Herba Cremanthodii hookerii mix in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 80% ~ 90%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 2 hours ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder,
Second step, Herba Pouzolziae Zeylanicae, Herba Polygoni Barbati, Radix Caraganae intermediae, Radix Primulae sieboldii and Radix berchemiae lineatae are mixed in described ratio, be ground into powder, be that the ethanol of 85% ~ 95% is as solvent with determining alcohol, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.25 ~ 1.27, dry with spray dryer, be ground into 100 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 3 ~ 5 times of second step mixture quality;
3rd step, surplus stock medical material is mixed in described ratio, add relative to mixture 4 ~ 6 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;
4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 3 ~ 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 35 ~ 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.3%, paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05%.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1: granule prepared by the present invention
Get Herba Asteris Flaccidi 260g, Herba cirsii esculenti 190g, Fructus Hippophae 210g, Caulis et folium cryptotaeniae japonicae 290g, Phragmites karka (Retz.) Trin. 120g, Herba Cremanthodii hookerii 350g, Radix Hibisci 160g, Folium Phragmitis 380g, Herba Cassiae Mimosoidis 160g, mountain trailing plants 290g, Rhizoma Lycopi Lucidi 190g, Radix Bischofiae Javanicae 260g, Rhizoma Platantherae Chloranthae 190g, Herba Pouzolziae Zeylanicae 310g, Herba Polygoni Barbati 190g, Radix Caraganae intermediae 360g, Herba Caryopteridis Terniflorae 100g, Folium Perillae Frutescentis 260g, Herba Thesii Longifolii 150g, Radix Primulae sieboldii 210g and Radix berchemiae lineatae 280g.
Its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 85%, be heated to boiling reflux 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.08Mpa, relative density is the mastic of 1.05, spraying dry, the inlet temperature 165 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.2 times in the dried cream powder obtained, makes granule, in 45 DEG C of dryings, obtains granule.
Embodiment 2: syrup prepared by the present invention
Get Herba Asteris Flaccidi 290g, Herba cirsii esculenti 160g, Fructus Hippophae 250g, Caulis et folium cryptotaeniae japonicae 260g, Phragmites karka (Retz.) Trin. 150g, Herba Cremanthodii hookerii 310g, Radix Hibisci 190g, Folium Phragmitis 360g, Herba Cassiae Mimosoidis 180g, mountain trailing plants 260g, Rhizoma Lycopi Lucidi 160g, Radix Bischofiae Javanicae 290g, Rhizoma Platantherae Chloranthae 160g, Herba Pouzolziae Zeylanicae 350g, Herba Polygoni Barbati 160g, Radix Caraganae intermediae 380g, Herba Caryopteridis Terniflorae 70g, Folium Perillae Frutescentis 290g, Herba Thesii Longifolii 120g, Radix Primulae sieboldii 250g and Radix berchemiae lineatae 260g.
Its preparation method comprises the following steps:
The first step, Herba Asteris Flaccidi, Herba cirsii esculenti, Fructus Hippophae, Caulis et folium cryptotaeniae japonicae, Phragmites karka (Retz.) Trin. and Herba Cremanthodii hookerii are mixed in described ratio, adding relative to the determining alcohol of 6 times, mixture is the ethanol of 85%, heating and refluxing extraction 3 times, each reflux, extract, 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 65 DEG C 60 DEG C, relative density is the medicinal liquid of 1.06, by dry with spray dryer for the concentrated solution after concentrated, be ground into 150 orders subsequently, obtain dry powder;
Second step, Herba Pouzolziae Zeylanicae, Herba Polygoni Barbati, Radix Caraganae intermediae, Radix Primulae sieboldii and Radix berchemiae lineatae being mixed in described ratio, be ground into powder, is that the ethanol of 85% is as solvent with determining alcohol, flood 60 hours, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.26, dry with spray dryer, be ground into 150 orders subsequently, obtain dry powder, the quality of the ethanol added is 4 times of second step mixture quality;
3rd step, mixes surplus stock medical material in described ratio, add relative to mixture 5 times amount determining alcohol be 75% alcohol reflux 3 times, each 2 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20, in 65 DEG C of reduced vacuum dryings, obtains dry powder;
4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 4 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 55%, potassium sorbate 0.24%.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 25-35g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine granules prepared by embodiments of the invention 1, (concentration is 8.85g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 44.25 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage granule LD50>44.25 crude drug/kg of the present invention, every day, maximum dosage-feeding was 88.5 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.26g crude drug/day/people, adult body weight in 60KG, average dosage is 0.138g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 30g) oral administration gavage Chinese medicine of the present invention is 641 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 granule of the present invention to three groups of mices (often organize 20) by 13.25,25.43 and 42.37g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: the pulmonary abscess patient that all 185 routine cases all derive from this Out-patient Department and are in hospital, is divided into treatment group and matched group at random by patient, wherein, and treatment group 93 example, man 51 example, female 42 example, 18 ~ 67 years old age; The course of disease 10 ~ 42d.Treatment group 92 example, man 49 example, female 43 example, 18 ~ 65 years old age; The course of disease 9 ~ 40d.Treatment group and matched group be no significant difference (P≤0.01) in age, sex, the course of disease and clinical symptoms, has comparability.
Diagnostic criteria: formulate with reference to sixth version " internal medicine ".1, high heat, cough, cough a large amount of pus fetid sputum or sanguinopurulent expectorant.2, large stretch of increase in density shade in the visible lung of x-ray chest film inspection, has bright region and fluid level in edge blurry or focus.3, blood test numeration of leukocyte increases, and Sputum culturing has various bacteria mixed infection.4, other pathological changes of pulmonary are got rid of.
Therapeutic Method:
Matched group: 1, antibiotic therapy: select effective antibiotics (mainly adopting penicillin, streptomycin, cephalosporins, levofloxacin, metronidazole, lincomycin and clindamycin etc.) according to Sputum culturing and drug sensitivity tests, adopt bigeminy or three-drug therapy, according to drug half-life, every day is applied 1-3 time, antibiotic regimen is generally 8 ~ 12 weeks, or until clinical symptoms disappears completely, X-ray film display vomica and inflammatory lesion dissipate completely, only till residual streak fiber shade.2, pus drain: postural drainage, every day 2-3 time, each 15-30 minute.3, oral expelling phlegm drugs ammonium chloride 0.3g, every day 3 times.A course for the treatment of 4 Mondays, treat three courses for the treatment of.
Treatment group: on the basis for the treatment of group, simultaneously oral Chinese medicine embodiment 1 granule of the present invention, each 20g, every day 3 times; A course for the treatment of 4 Mondays, treat three courses for the treatment of.
Curative effect judging standard: (1) cures: symptom and abnormal sign disappear, and chest X-ray vomica disappears, and around inflammation absorbs, and diseased region remains a few fibres cord shadow.(2) effective: body temperature is normal, cough, expectoration obviously alleviate, and chest X-ray inflammation and cavity obviously reduce.(3) effective: body temperature is normal, and cough and expectoration alleviates, chest X-ray inflammation and cavity have and reduce.(4) invalid: symptom, sign, chest X-ray are unchanged or increase the weight of.
Therapeutic outcome: two groups treat 3 courses for the treatment of respectively after, statistical result is see table 1.
Table 1 liang group treats Clinical efficacy comparison (unit: example) after 3 courses for the treatment of respectively
| Group | Number of cases | Cure | Effective | Effectively | Invalid | Total effective rate |
| Treatment group | 93 | 69 | 13 | 9 | 2 | 91(97.85％) |
| Matched group | 92 | 48 | 19 | 12 | 13 | 79(85.87％) |
As can be seen from Table 1, treatment group adopts Chinese medicine of the present invention, coordinates western medical treatment pulmonary abscess, relative to matched group, on therapeutic effect, can significantly improve cure rate and total effective rate, have significant improvement.
Untoward reaction: two groups of patients, all without anaphylaxis, damage without Liver and kidney function, the aspect untoward reaction such as apnea system, digestive system and nervous system.
Concrete case: model, man, 54 years old, patient has more than 10 years smoking history, suddenly cough after suffering from cold, chest pain about 1 week, rear Yin Gaore, cough a large amount of pus fetid sputum to be admitted to hospital and to see a doctor, through blood testing, the inspections such as sputum cultivation and x-ray rabat, be diagnosed as pulmonary abscess, give antibiotic therapy, the Western medicine colligation treatments such as postural drainage, the granule of oral inventive embodiments 1 simultaneously, each 20g, every day 3 times, take 8 weeks, symptom and abnormal sign disappear, chest X-ray vomica disappears, around inflammation absorbs, diseased region remains a few fibres cord shadow, cure, follow up a case by regular visits to 6 months without recurrence.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (8)
1. treat the Chinese medicine preparation of pulmonary abscess for one kind, it is characterized in that, described Chinese medicine preparation comprises following raw medicinal material: Herba Asteris Flaccidi, Herba cirsii esculenti, Fructus Hippophae, Caulis et folium cryptotaeniae japonicae, Phragmites karka (Retz.) Trin., Herba Cremanthodii hookerii, Radix Hibisci, Folium Phragmitis, Herba Cassiae Mimosoidis, mountain trailing plants, Rhizoma Lycopi Lucidi, Radix Bischofiae Javanicae, Rhizoma Platantherae Chloranthae, Herba Pouzolziae Zeylanicae, Herba Polygoni Barbati, Radix Caraganae intermediae, Herba Caryopteridis Terniflorae, Folium Perillae Frutescentis, Herba Thesii Longifolii, Radix Primulae sieboldii and Radix berchemiae lineatae.
2. Chinese medicine preparation as claimed in claim 1, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Asteris Flaccidi 25 ~ 35 parts, Herba cirsii esculenti 10 ~ 20 parts, Fructus Hippophae 15 ~ 25 parts, Caulis et folium cryptotaeniae japonicae 20 ~ 30 parts, Phragmites karka (Retz.) Trin. 5 ~ 15 parts, Herba Cremanthodii hookerii 25 ~ 35 parts, Radix Hibisci 10 ~ 20 parts, Folium Phragmitis 30 ~ 40 parts, Herba Cassiae Mimosoidis 15 ~ 25 parts, mountain trailing plants 20 ~ 30 parts, Rhizoma Lycopi Lucidi 15 ~ 25 parts, Radix Bischofiae Javanicae 20 ~ 30 parts, Rhizoma Platantherae Chloranthae 10 ~ 20 parts, Herba Pouzolziae Zeylanicae 25 ~ 35 parts, Herba Polygoni Barbati 15 ~ 25 parts, Radix Caraganae intermediae 30 ~ 40 parts, Herba Caryopteridis Terniflorae 5 ~ 15 parts, Folium Perillae Frutescentis 25 ~ 35 parts, Herba Thesii Longifolii 10 ~ 20 parts, Radix Primulae sieboldii 15 ~ 25 parts and Radix berchemiae lineatae 20 ~ 30 parts.
3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Asteris Flaccidi 25 ~ 30 parts, Herba cirsii esculenti 15 ~ 20 parts, Fructus Hippophae 20 ~ 25 parts, Caulis et folium cryptotaeniae japonicae 25 ~ 30 parts, Phragmites karka (Retz.) Trin. 10 ~ 15 parts, Herba Cremanthodii hookerii 30 ~ 35 parts, Radix Hibisci 15 ~ 20 parts, Folium Phragmitis 35 ~ 40 parts, Herba Cassiae Mimosoidis 15 ~ 20 parts, mountain trailing plants 25 ~ 30 parts, Rhizoma Lycopi Lucidi 15 ~ 20 parts, Radix Bischofiae Javanicae 25 ~ 30 parts, Rhizoma Platantherae Chloranthae 15 ~ 20 parts, Herba Pouzolziae Zeylanicae 30 ~ 35 parts, Herba Polygoni Barbati 15 ~ 20 parts, Radix Caraganae intermediae 35 ~ 40 parts, Herba Caryopteridis Terniflorae 5 ~ 10 parts, Folium Perillae Frutescentis 25 ~ 30 parts, Herba Thesii Longifolii 10 ~ 15 parts, Radix Primulae sieboldii 20 ~ 25 parts and Radix berchemiae lineatae 25 ~ 30 parts.
4. the Chinese medicine preparation as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Asteris Flaccidi 26 parts, Herba cirsii esculenti 19 parts, Fructus Hippophae 21 parts, Caulis et folium cryptotaeniae japonicae 29 parts, Phragmites karka (Retz.) Trin. 12 parts, Herba Cremanthodii hookerii 35 parts, Radix Hibisci 16 parts, Folium Phragmitis 38 parts, Herba Cassiae Mimosoidis 16 parts, mountain trailing plants 29 parts, Rhizoma Lycopi Lucidi 19 parts, Radix Bischofiae Javanicae 26 parts, Rhizoma Platantherae Chloranthae 19 parts, Herba Pouzolziae Zeylanicae 31 parts, Herba Polygoni Barbati 19 parts, Radix Caraganae intermediae 36 parts, Herba Caryopteridis Terniflorae 10 parts, Folium Perillae Frutescentis 26 parts, Herba Thesii Longifolii 15 parts, Radix Primulae sieboldii 21 parts and Radix berchemiae lineatae 28 parts.
5. the Chinese medicine preparation as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
6. the Chinese medicine preparation as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is syrup, and its preparation method comprises the following steps:
The first step, by Herba Asteris Flaccidi, Herba cirsii esculenti, Fructus Hippophae, Caulis et folium cryptotaeniae japonicae, Phragmites karka (Retz.) Trin. and Herba Cremanthodii hookerii mix in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 80% ~ 90%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 2 hours ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder,
Second step, Herba Pouzolziae Zeylanicae, Herba Polygoni Barbati, Radix Caraganae intermediae, Radix Primulae sieboldii and Radix berchemiae lineatae are mixed in described ratio, be ground into powder, be that the ethanol of 85% ~ 95% is as solvent with determining alcohol, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.25 ~ 1.27, dry with spray dryer, be ground into 100 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 3 ~ 5 times of second step mixture quality;
3rd step, surplus stock medical material is mixed in described ratio, add relative to mixture 4 ~ 6 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;
4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 3 ~ 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 35 ~ 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.3%, paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05%.
7. a preparation method for the Chinese medicine preparation described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is granule, and it comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
8. a preparation method for the Chinese medicine preparation described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is syrup, and its preparation method comprises the following steps:
The first step, by Herba Asteris Flaccidi, Herba cirsii esculenti, Fructus Hippophae, Caulis et folium cryptotaeniae japonicae, Phragmites karka (Retz.) Trin. and Herba Cremanthodii hookerii mix in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 80% ~ 90%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 2 hours ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder,
Second step, Herba Pouzolziae Zeylanicae, Herba Polygoni Barbati, Radix Caraganae intermediae, Radix Primulae sieboldii and Radix berchemiae lineatae are mixed in described ratio, be ground into powder, be that the ethanol of 85% ~ 95% is as solvent with determining alcohol, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.25 ~ 1.27, dry with spray dryer, be ground into 100 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 3 ~ 5 times of second step mixture quality;
3rd step, surplus stock medical material is mixed in described ratio, add relative to mixture 4 ~ 6 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;
4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 3 ~ 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 35 ~ 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.3%, paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05%.
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| CN106174539A (en) * | 2016-07-15 | 2016-12-07 | 赵志库 | A kind of food additive |
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| CN105169017A (en) * | 2015-09-01 | 2015-12-23 | 孙富广 | Traditional Chinese medicine for treating kidney stone and preparation method of traditional Chinese medicine |
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| CN105169017A (en) * | 2015-09-01 | 2015-12-23 | 孙富广 | Traditional Chinese medicine for treating kidney stone and preparation method of traditional Chinese medicine |
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| CN106174539A (en) * | 2016-07-15 | 2016-12-07 | 赵志库 | A kind of food additive |
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