CN104398938A

CN104398938A - Traditional Chinese medicine for treating wind-heat invading lung lobar pneumonia and preparation method

Info

Publication number: CN104398938A
Application number: CN201410664205.XA
Authority: CN
Inventors: 杨光霞; 程云涛
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-11-19
Filing date: 2014-11-19
Publication date: 2015-03-11

Abstract

The invention discloses a traditional Chinese medicine for treating wind-heat invading lung lobar pneumonia and a preparation method. The traditional Chinese medicine comprises the following raw materials: gardenia, radices trichosanthis, lalang grass rhizome, honeysuckle, dandelion, purple flower holly leaves, cordate houttuynia, glycyrrhizae, polygonum cuspidatum, commeline communis, radix bupleuri, coffee senna fruits or seeds, lumbricus, semen lepidii, folium isatidis, radix isatidis, cyrtomium fortunei, polygonatum odoratum, sealwort, Chinese yam, potentilla anserina, radix ophiopogonis, rhizoma atractylodis, platycodon grandiflorum, bletilla formosana, momordica grosvenori, radix stemonae and aster. The medicine has the benefits that the medicine has effects of dispelling wind, removing heat, and clearing away the heat and toxic materials, can nourish yin, eliminate phlegm, tonify a stomach, promote production of body fluid, diffuse a lung and relieve a cough, and mainly treats the wind-heat invading lung lobar pneumonia; furthermore, the medicine has simple and convenient preparation technology, and is small in toxic and side effects and convenient to administer; an agent is easy to manufacture; the medicine is a new medicine which is low in cost, and can reach a focus; the curing time is short; and the lobar pneumonia has low possibility of recurrence after curing.

Description

A kind of Chinese medicine and preparation method for the treatment of wind-heat invading lung type lobar pneumonia

Technical field

The present invention relates to pharmaceutical technology, particularly a kind of Chinese medicine and preparation method for the treatment of wind-heat invading lung type lobar pneumonia.

Background technology

Lobar pneumonia (lobarpneumonia) is mainly caused by streptococcus pneumoniae, and pathological changes involves an above lung tissue of lung section, the acute inflammation oozed out based on Diffuse fibrous element in alveolar.Pathological changes originates in local alveolar, and rapid spread to lung section or whole great Ye.Onset is hurried clinically, and Chang Yigao heat, aversion to cold start, and then occur chest pain, cough, cough rusty expectoration, dyspnea, and have pulmonary consolidation sign and leukocyte counts to increase.The common inducement of disease is suffered from cold, tired or drench with rain.

The cause of disease

Various bacteria all can cause lobar pneumonia, but the overwhelming majority is streptococcus pneumoniae, wherein the strongest with III type pathogenicity.Streptococcus pneumoniae is gram-negative cocci, has pod membrane, and its pathogenicity is because the pod membrane of macromolecule polysaccharide body is to the invasion and attack effect of tissue.Minority is pneumobacillus, golden yellow * color staphylococcus, Hemolytic streptococcus, hemophilus influenza etc.Streptococcus pneumoniae is the normal parasitic flora of oral cavity and nasopharynx part, if when the resistance of the discharge of bacteria self-purification function of respiratory tract and body is normal, do not cause pneumonia.When body catch cold, overtired, drunk, flu, diabetes, immunologic hypofunction etc. make respiratory tract defense function weakened, antibacterial invades alveolar makes alveolar wall capillary permeability strengthen by allergy, serosity and cellulose ooze out, in rich protein-contg exudate, antibacterial breeds rapidly, and spread to contiguous lung tissue by interalveolar pores or alveolar bronchiole, involve a lung section or the whole lobe of the lung.The transudate spreading frenulum bacterium between great Ye is caused by the leaf bronchogenic spread.

Clinical manifestation

1. onset is hurried, shiver with cold, high heat, chest pain, coughs, coughs rusty expectoration.The extensive person of pathological changes can accompany tachypnea and cyanosis.

2. some cases has Nausea and vomiting, abdominal distention, diarrhoea.

3. serious symptom person can have neuropsychic symptom, as dysphoria, delirium etc.Also loop exhaustion around can occur, accompanying infection is suffered a shock, and claims shock type (or toxic) pneumonia.

4. face of acute ill, rapid breathing, flaring of alaenasi.

5. initial lung sign not obvious or only have respiratory murmur lower and pleuritic rub.Can there be typical sign the consolidation phase, and as Ipsilateral respiratory movement weakens, vocal fremitus strengthens, dull percussion note, and auscultation respiratory murmur lowers, and has moist rale or pathologic bronchial breathing sound.

Primary disease belongs to by Chinese medicine " breathing with cough ", " pulmonary distension ", the category such as " pathogenic wind-warm ".Think that primary disease is many in positive QI-insufficiency, when defending outer miopragia, caused by being invaded by exogenous pathogen.As Qing Dynasty's doctor's Ye Gui a, famous physician of the Qing Dynasty was once pointed out " warm pathogen tend to attack the upper orifices, attacking the lung first ".Namely the exopathogen such as pathogenic wind-warm invasion and attack human body, relates to lungs, produces a series of pathological change.Exopathogen both can be the heresy of wind heat, also can be the heresy of wind and cold, defends, make impaired depurative descending of lung QI and produce disease, also can pathogenic heat pent up in lung, or phlegm-damp staying in lung from the beginning of infringement lung.Primary disease is in evolution, and the friendship of generally just struggling against through heresy is striven, and often just can win heresy, and the card feelings of impairment of both QI and YIN can appear in the later stage.If vital QI cannot conquer pathogen, yang-energy can be formed for de-critical syndrome.

Chinese medical discrimination is divided into:

1, wind-heat invading the lung: fever without sweat or hypohidrosis, micro evil wind is trembled with fear, and cough expectorant is few, and headache, mouth is yearningly micro-.Tongue tip side of red, white and thin fur, floating and rapid pulse.2, phlegm-heat obstructing in the lung: fever of the body excessive thirst, sweating, coughs rough, or expectorant fulminant leucorrhagia with yellowish discharge blood, and feeling of oppression and pain in the chest is thirsty.Red tongue with yellow fur, full and rapid pulse or sliding number.3, exuberant lung-stomach heat: fever of the body be in the afternoon very, vexedly regretfully to comply with, thirsty polydipsia, cough expectorant Huang, abdominal distention constipation.Red tongue, yellow fur or greyish black and dry, slippery and rapid pulse.4, heat-blockage pericardium: high fever, dysphoria, feeling thirst but no desire to drink, very then unconsciousness and delirium, convulsion are fainted or extreme cold of the limbs.The few Tianjin of crimson tongue, yellow fur, wiry and frequent pulse or heavy number.5, deficiency of both QI and YIN: body febrile lysis, dry cough expectorant is few and sticky, and spontaneous perspiration god is tired, anorexia xerostomia.The few tongue of red tongue, thready pulse or count accurately.6, evil sunken just de-: short of breath, flaring of nares, pale complexion, dripping sweat, very then greasy sweating, extreme cold of the limbs, cyanosis, dysphoria, fever of the body rapid drawdown.Or onset is without fever of the body, pale white complexion, mind is fuzzy gradually.Light purplish tongue, thready and rapid pulse without strength, or faint pulse being about to disappear.

Western medicine therapy

1, antibiotic therapy: penicillin, sulfonamides, erythromycin, clean ancient mycin, cephalexin number;

2, symptomatic treatment: (1) high hot person: aspirin, antondin; (2) chest pain is violent: oral codeine; (3) cough is coughed up phlegm: mixture of ammonium chloride; (4) water-electrolyte balance is kept.(5) respiratory failure of suffering a shock handles accordingly.

But western medical treatment lobar pneumonia, the course for the treatment of is longer, and widely apply antibiotic for a long time, expectorant easily produces drug resistance, clinical efficacy is not satisfactory, and the easy recurrent exerbation of the state of an illness, has a strong impact on the quality of life etc. of patient.

But, Chinese medicine lobar pneumonia, possess unique advantage and feature: utilize Traditional Chinese medical theory, on the basis of Overall View, by regulating qi-blood circulating, enhancing human body immunity power, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, treat according to different disease Mutiple Targets, strengthen the respiratory function of respiratory muscle, promote expectoration cough-relieving, relieving asthma, keep respiratory passage unblocked, drug effect is gone directly focus, safe and effective, the course for the treatment of is shorter, and not easily produce drug resistance, cost price is lower, convenient drug administration, patient is easy to accept, cure rate can be significantly improved, reduce complication, reduce relapse rate, significantly improve the quality of life etc. of patient.

Summary of the invention

The technical problem to be solved in the present invention is to provide a kind of Chinese medicine and preparation method for the treatment of wind-heat invading lung type lobar pneumonia, the present invention has effect of wind-dispelling heat-dissipating, heat-clearing and toxic substances removing, hold concurrently eliminate the phlegm with yin nourishing, reinforcing stomach reg fluid, lung qi dispersing cough-relieving, cure mainly wind-heat invading lung type lobar pneumonia.The present invention utilizes Traditional Chinese medical theory, and formula is simple, processing technology is easy, the little and convenient drug administration of toxic and side effects, and medicament is easy to manufacture, new drug with low cost.The present invention is Chinese medicine preparation, but the Chinese medicine that selected abnormal smells from the patient is gentle, makes the abnormal smells from the patient of Chinese medicine preparation and light.The present invention adopts the Chinese crude drug of different properties, has carried out scientific compatibility, can reach desirable therapeutic effect, and safety, toxic and side effects is little, and preparation is simple, and focus of going directly, healing time is short, not easily recurs after healing.

In order to realize foregoing invention object, the invention provides a kind of Chinese medicine for the treatment of wind-heat invading lung type lobar pneumonia, wherein, following raw medicinal material is comprised: Fructus Gardeniae, Radix Trichosanthis, Rhizoma Imperatae, Flos Lonicerae, Herba Taraxaci, Ilex purpurea Hassk.[I.chinensis Sims, Herba Houttuyniae, Radix Glycyrrhizae, Rhizoma Polygoni Cuspidati, Herba Sedi, Commeline communis, Radix Bupleuri, Semen Cassiae Occidemtalis, Pheretima, Semen Lepidii (Semen Descurainiae), Folium Isatidis, Radix Isatidis, Rhizoma Osmundae, Rhizoma Polygonati Odorati, Rhizoma Polygonati, Rhizoma Dioscoreae, Radix potentillae anserinae, Radix Ophiopogonis, Rhizoma Atractylodis, Radix Platycodonis, Rhizoma Pleiones Yunnanensis, Fructus Momordicae, the Radix Stemonae and Radix Asteris.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Fructus Gardeniae 22-32 part, Radix Trichosanthis 26-39 part, Rhizoma Imperatae 20-30 part, Flos Lonicerae 28-38 part, Herba Taraxaci 16-25 part, Ilex purpurea Hassk.[I.chinensis Sims 12-21 part, Herba Houttuyniae 11-19 part, Radix Glycyrrhizae 9-15 part, Rhizoma Polygoni Cuspidati 13-20 part, Herba Sedi 10-16 part, Commeline communis 12-17 part, Radix Bupleuri 10-15 part, Semen Cassiae Occidemtalis 12-16 part, Pheretima 8-14 part, Semen Lepidii (Semen Descurainiae) 10-15 part, Folium Isatidis 6-12 part, Radix Isatidis 6-11 part, Rhizoma Osmundae 5-9 part, Rhizoma Polygonati Odorati 14-20 part, Rhizoma Polygonati 13-19 part, Rhizoma Dioscoreae 12-16 part, Radix potentillae anserinae 14-21 part, Radix Ophiopogonis 17-27 part, Rhizoma Atractylodis 12-17 part, Radix Platycodonis 11-16 part, Rhizoma Pleiones Yunnanensis 16-20 part, Fructus Momordicae 13-16 part, Radix Stemonae 15-25 part and Radix Asteris 10-18 part.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Fructus Gardeniae 23-30 part, Radix Trichosanthis 28-36 part, Rhizoma Imperatae 20-26 part, Flos Lonicerae 28-35 part, Herba Taraxaci 18-23 part, Ilex purpurea Hassk.[I.chinensis Sims 14-18 part, Herba Houttuyniae 13-16 part, Radix Glycyrrhizae 9-13 part, Rhizoma Polygoni Cuspidati 15-18 part, Herba Sedi 10-14 part, Commeline communis 13-16 part, Radix Bupleuri 11-14 part, Semen Cassiae Occidemtalis 13-16 part, Pheretima 10-13 part, Semen Lepidii (Semen Descurainiae) 11-14 part, Folium Isatidis 7-10 part, Radix Isatidis 6-9 part, Rhizoma Osmundae 5-8 part, Rhizoma Polygonati Odorati 16-19 part, Rhizoma Polygonati 14-17 part, Rhizoma Dioscoreae 13-16 part, Radix potentillae anserinae 14-19 part, Radix Ophiopogonis 18-23 part, Rhizoma Atractylodis 14-17 part, Radix Platycodonis 11-15 part, Rhizoma Pleiones Yunnanensis 16-19 part, Fructus Momordicae 13-15 part, Radix Stemonae 18-23 part and Radix Asteris 11-15 part.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Fructus Gardeniae 25 parts, Radix Trichosanthis 30 parts, Rhizoma Imperatae 22 parts, Flos Lonicerae 30 parts, Herba Taraxaci 20 parts, Ilex purpurea Hassk.[I.chinensis Sims 15 parts, Herba Houttuyniae 15 parts, Radix Glycyrrhizae 10 parts, Rhizoma Polygoni Cuspidati 16 parts, Herba Sedi 11 parts, Commeline communis 14 parts, Radix Bupleuri 12 parts, Semen Cassiae Occidemtalis 14 parts, Pheretima 12 parts, Semen Lepidii (Semen Descurainiae) 13 parts, Folium Isatidis 8 parts, Radix Isatidis 8 parts, Rhizoma Osmundae 6 parts, Rhizoma Polygonati Odorati 18 parts, Rhizoma Polygonati 15 parts, Rhizoma Dioscoreae 15 parts, Radix potentillae anserinae 16 parts, Radix Ophiopogonis 20 parts, Rhizoma Atractylodis 15 parts, Radix Platycodonis 12 parts, Rhizoma Pleiones Yunnanensis 18 parts, Fructus Momordicae 15 parts, the Radix Stemonae 20 parts and Radix Asteris 12 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Fructus Gardeniae 23 parts, Radix Trichosanthis 36 parts, Rhizoma Imperatae 20 parts, Flos Lonicerae 35 parts, Herba Taraxaci 23 parts, Ilex purpurea Hassk.[I.chinensis Sims 14 parts, Herba Houttuyniae 16 parts, Radix Glycyrrhizae 13 parts, Rhizoma Polygoni Cuspidati 15 parts, Herba Sedi 14 parts, Commeline communis 16 parts, Radix Bupleuri 11 parts, Semen Cassiae Occidemtalis 13 parts, Pheretima 13 parts, Semen Lepidii (Semen Descurainiae) 11 parts, Folium Isatidis 7 parts, Radix Isatidis 9 parts, Rhizoma Osmundae 5 parts, Rhizoma Polygonati Odorati 19 parts, Rhizoma Polygonati 14 parts, Rhizoma Dioscoreae 16 parts, Radix potentillae anserinae 14 parts, Radix Ophiopogonis 18 parts, Rhizoma Atractylodis 14 parts, Radix Platycodonis 15 parts, Rhizoma Pleiones Yunnanensis 19 parts, Fructus Momordicae 13 parts, the Radix Stemonae 23 parts and Radix Asteris 11 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Fructus Gardeniae 30 parts, Radix Trichosanthis 28 parts, Rhizoma Imperatae 26 parts, Flos Lonicerae 28 parts, Herba Taraxaci 18 parts, Ilex purpurea Hassk.[I.chinensis Sims 18 parts, Herba Houttuyniae 13 parts, Radix Glycyrrhizae 9 parts, Rhizoma Polygoni Cuspidati 18 parts, Herba Sedi 10 parts, Commeline communis 13 parts, Radix Bupleuri 14 parts, Semen Cassiae Occidemtalis 16 parts, Pheretima 10 parts, Semen Lepidii (Semen Descurainiae) 14 parts, Folium Isatidis 10 parts, Radix Isatidis 6 parts, Rhizoma Osmundae 8 parts, Rhizoma Polygonati Odorati 16 parts, Rhizoma Polygonati 17 parts, Rhizoma Dioscoreae 13 parts, Radix potentillae anserinae 19 parts, Radix Ophiopogonis 18 parts, Rhizoma Atractylodis 17 parts, Radix Platycodonis 11 parts, Rhizoma Pleiones Yunnanensis 169 parts, Fructus Momordicae 14 parts, the Radix Stemonae 18 parts and Radix Asteris 15 parts.

In order to realize goal of the invention better, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine of wind-heat invading lung type lobar pneumonia, and when the dosage form of described Chinese medicine is spray, its preparation method comprises the following steps:

A, take all raw medicinal materials in described ratio, add relative to the mixture quality 3-5 obtained water soaking 3-10 hour doubly, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, decoct 3 times, merge decoction liquor to filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;

B, the medicinal residues of step a are added 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid, 80-160 order filters, get 6000-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;

C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.

In order to realize goal of the invention better, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine of wind-heat invading lung type lobar pneumonia, and when the dosage form of described Chinese medicine is for during containing tablet, its preparation method comprises the following steps:

The first step, by ratio mixing described in Radix Glycyrrhizae, Rhizoma Imperatae, Rhizoma Polygonati Odorati, Rhizoma Polygonati, Rhizoma Dioscoreae, Radix potentillae anserinae and Radix Ophiopogonis, by the soak with ethanol of the determining alcohol 90% ~ 95% of 4 ~ 6 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered; By filtering residue again by the soak with ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8 ~ 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, Rhizoma Atractylodis, Radix Platycodonis, Rhizoma Pleiones Yunnanensis, Fructus Momordicae, the Radix Stemonae and Radix Asteris are mixed in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 3 ~ 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water soaking of 2 ~ 5 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water soaking of 1 ~ 3 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge twice filtrate, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the carboxymethyl starch sodium of mixture quality 0.05 ~ 0.1 times, the microcrystalline Cellulose of 0.05 ~ 0.1 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.01 ~ 0.05 times obtained, then with decompressor by granule tabletted, obtain containing tablet.

In order to realize goal of the invention better, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine of wind-heat invading lung type lobar pneumonia, and when the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

The beneficial effect that technical scheme provided by the invention is brought is: the present invention has effect of wind-dispelling heat-dissipating, heat-clearing and toxic substances removing, hold concurrently eliminate the phlegm with yin nourishing, reinforcing stomach reg fluid, lung qi dispersing cough-relieving, cure mainly wind-heat invading lung type lobar pneumonia.The present invention utilizes Traditional Chinese medical theory, and formula is simple, processing technology is easy, the little and convenient drug administration of toxic and side effects, and medicament is easy to manufacture, with low cost.The present invention is Chinese medicine preparation, but the Chinese medicine that selected abnormal smells from the patient is gentle, makes the abnormal smells from the patient of Chinese medicine preparation and light.The present invention adopts the Chinese crude drug of different properties, has carried out scientific compatibility, can reach desirable therapeutic effect, and safety, toxic and side effects is little, and preparation is simple, and focus of going directly, healing time is short, not easily recurs after healing.

Detailed description of the invention

Therefore, treatment wind-heat invading lung type lobar pneumonia, the present invention for primary treatment principle, selects prescription: Fructus Gardeniae, Radix Trichosanthis, Rhizoma Imperatae, Flos Lonicerae, Herba Taraxaci, Ilex purpurea Hassk.[I.chinensis Sims, Herba Houttuyniae, Radix Glycyrrhizae, Rhizoma Polygoni Cuspidati, Herba Sedi, Commeline communis, Radix Bupleuri, Semen Cassiae Occidemtalis, Pheretima, Semen Lepidii (Semen Descurainiae), Folium Isatidis, Radix Isatidis, Rhizoma Osmundae, Rhizoma Polygonati Odorati, Rhizoma Polygonati, Rhizoma Dioscoreae, Radix potentillae anserinae, Radix Ophiopogonis, Rhizoma Atractylodis, Radix Platycodonis, Rhizoma Pleiones Yunnanensis, Fructus Momordicae, the Radix Stemonae and Radix Asteris with wind-dispelling heat-dissipating, heat-clearing and toxic substances removing.

In its side, Fructus Gardeniae, Radix Trichosanthis, Rhizoma Imperatae, Flos Lonicerae, Herba Taraxaci, Rhizoma Polygoni Cuspidati, Herba Patriniae, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae), Herba Sedi, Commeline communis, Radix Bupleuri, Semen Cassiae Occidemtalis, Pheretima, Semen Lepidii (Semen Descurainiae), Folium Isatidis, Radix Isatidis, Rhizoma Osmundae evacuate lung-heat, heat-clearing and toxic substances removing, because lobar pneumonia is viral infection, therefore apply a large amount of heat-clearing and toxic substances removing medicine in early days, enter inner heat-transformation to prevent it and increase the weight of the state of an illness; Radix Glycyrrhizae, Rhizoma Imperatae, Rhizoma Polygonati Odorati, Rhizoma Polygonati, Rhizoma Dioscoreae, Radix potentillae anserinae, Radix Ophiopogonis reinforcing stomach reg fluid in case the heresy consumption impairment of YIN liquid of pyretic toxicity, make deficiency of vital QI without resisting heresy strenuously; Rhizoma Atractylodis, Radix Platycodonis are the product of pungent temperature using corrigent, can help that all medicines are eliminating evil goes out, and stomach liter can be assisted again to reach body fluid, prevent pyretic toxicity impairing the lung, Rhizoma Pleiones Yunnanensis, Fructus Momordicae, the Radix Stemonae and Radix Asteris cough-relieving; Make a general survey of full side, compatibility is rigorous.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Fructus Gardeniae: bitter, cold.Enter the heart, liver, lung, stomach warp.Clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body.

Radix Trichosanthis: sweet, micro-hardship, acid, be slightly cold.Enter lung, stomach warp.Clearing away heat and promoting production of body fluid, detumescence and apocenosis.

Rhizoma Imperatae: sweet, cold.Enter lung, stomach warp.Clearing away heat and promoting production of body fluid, cooling blood for hemostasis.

Flos Lonicerae: sweet, cold.Enter lung, stomach, the heart, spleen channel.Heat-clearing and toxic substances removing.

Herba Taraxaci: Herba Taraxaci: nature and flavor are sweet, micro-hardship, cold.Enter spleen, stomach, kidney three warp.Heat-clearing and toxic substances removing, draws out pus by applying a plaster to the affected part and attacks carbuncle, inducing diuresis for treating stranguria syndrome." Bencao Jingshu ": " Herba Taraxaci is hidden sweet flat, and its property is nontoxic.When being enter stomach into liver, the key medicine of antipyretic removing heat from blood.Acute mastitis belongs to Liver Channel, and married woman is after row, and Liver Channel is taken charge, therefore housewife's human milk carbuncle breast poison, and should give birth to warm good." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " apply all pyogenic infections from tumour or sore, the ruined tinea skin ulcer of scabies; Dispel the wind, disappear all sores, loose scrofula tuberculosis; Stop little having blood in stool, control the five types of stranguria difficulty in urination, sharp bladder." heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.

Ilex purpurea Hassk.[I.chinensis Sims: bitter, puckery, cold.Heat-clearing and toxic substances removing, cooling blood for hemostasis.

Herba Houttuyniae: pungent, is slightly cold.Enter lung meridian.Heat-clearing and toxic substances removing, subduing inflammation.

Rhizoma Polygoni Cuspidati: mildly bitter flavor, cold nature, returns liver, gallbladder, lung meridian, has heat-clearing and toxic substances removing, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, the effect of preventing phlegm from forming and stopping coughing, for arthralgia, and jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus.

Herba Sedi: cool in nature is sweet in the mouth, cool; Return liver, gallbladder, small intestine meridian.Eliminating damp-heat, removing toxic substances.For jaundice due to damp-heat, dysuria, carbuncle skin infection, acute hepatitis, chronic hepatitis.Have and reduce glutamate pyruvate transaminase effect.For the activeness of acute hepatitis, chronic persistent hepatitis, chronic hepatitis.

Commeline communis: sweet in the mouth, micro-hardship, cold in nature.Energy heat clearing away, removing toxic substances, diuresis.For the good medicine of swelling diuretic, heat-clearing and toxic substances removing, in addition hordeolum, pharyngitis, tonsillitis, cervical erosion, Agkistrodon halys are bitten good efficacy.Function cures mainly: row water, heat clearing away, removing heat from blood, removing toxic substances.Harness the river swollen, beriberi, dysuria, flu, erysipelas, parotitis, icterohepatitis, hematodiarrhoea, malaria, epistaxis, hematuria, metrorrhagia, leucorrhea, laryngopharynx swelling and pain, carbuncle furuncle.

Radix Bupleuri: cold nature, bitter in the mouth, pungent, return Liver Channel, gallbladder meridian, tool depressed liver-energy dispersing and function of gallbladder promoting, dredge gas resolving depression, loose effect of fire.Function: expelling pathogenic factors from the exterior expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.Cure mainly: the heating that cures cold, cold and heat deficient fever.Children's's varioliform exanthema waste heat, emaciation and sallow complexion abdominal part expands, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, and uterus comes off, menoxenia.

Semen Cassiae Occidemtalis: bitter, is slightly cold, nontoxic.Liver heat removing and eyesight improving, stomach invigorating, relieving constipation, removing toxic substances.Control conjunctival congestion and swelling pain, dizzy feeling of fullness in the head, dyspepsia, stomachache, stomachache, dysentery, constipation.

Pheretima: heat clearing away, spasmolytic, diuresis, removing toxic substances.For calentura mania and irritation, infantile convulsion, cough with asthma, headache conjunctival congestion, laryngopharynx swelling and pain, urinary obstruction, Fengshi Guanjie pain, the diseases such as hemiplegia Pheretima dish.External is coated with the disease such as erysipelas, dermatitis rhus.

Semen Lepidii (Semen Descurainiae): pungent, bitter, cold; Return lung meridian, heart channel, Liver Channel, stomach warp, urinary bladder channel.Function eliminating the pathogens from the lung sending down the abnormal ascending QI, eliminating phlegm and relieving asthma, inducing diuresis to remove edema, lets out by heresy.Cure mainly sputum stop up the dyspnea and cough with excessive sputum of lung, lung abscess, edema, breast abdomen hydrops, dysuria, chronic pulmonary heart disease, heart failure breathe heavily swollen, scrofula tuberculosis.

Folium Isatidis: bitter, cold; Enter liver, the heart, stomach warp.Compendium of Material Medica: " main pyrotoxic dysentery, jaundice, sore throat, erysipelas." " LANYE juice, separates Mylabris, Yuan green grass or young crops, tree of heaven chicken, Cinnabaris, arsenicum sablimatum poison." " book on Chinese herbal medicine just ": " is controlled pestilence pyretic toxicity and goes mad, wind heat macule, and carbuncle and ulcer swells and ache, relieving thirst and restlessness, only epistaxis, haematemesis, kills infantile malnutrition erosion, incised wound curare.Allly to hold concurrently malicious person with heat, all LANYE should smash juice and use it." heat clearing away, removing toxic substances, removing heat from blood, hemostasis.

Radix Isatidis: nature and flavor, bitter cold.Heat clearing away, removing toxic substances, removing heat from blood, sore-throat relieving.Cure mainly maculae caused by violent heat pathogen, high heat headache, major part pestilence, crimson tongue is purple dark, scarlet fever, erysipelas, mumps, sore throat, and skin ulcer is swollen, carbuncle, chickenpox, measles, hepatitis, influenza, epidemic encephalitis, encephalitis b, pneumonia, and coma tells nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash; Epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis can be prevented and treated.

Rhizoma Osmundae: nature and flavor are bitter, are slightly cold.Slightly poisonous.Return liver, spleen channel.There is heat-clearing and toxic substances removing, cooling blood for hemostasis, effect of parasite killing.Anemopyretic cold can be cured mainly, maculae caused by violent heat pathogen; Heat in blood is hemorrhage; Worm disease; This product also can be used for treatment burn and scald and injures married woman and be with inferior disease.

Rhizoma Polygonati Odorati: sweet in the mouth, property is put down; Attach to the lung and stomach meridians." property of medicine opinion ": " disease cold and heat time main, interior tonifying for the deficiency, removes asthenia exopathogenic heat, and headache is uneasy, adds and good with it." " Japan hanako materia medica ": " except unhappy, quench the thirst, profit cardiopulmonary, mend five kinds of strain and seven kinds of impairment, deficient, waist foot pain, it is capable fanatical." Compendium of Material Medica: " main air temperature spontaneous perspiration is scorching hot, and malaria with general debility cold and heat, taste void is weary, man's frequent micturition, and consumption of essence, all are deficient.”

Rhizoma Polygonati: sweet in the mouth, property is put down, and enters lung, spleen, kidney channel, there is enriching qi and yin, spleen invigorating lung moistening, effect of enriching kidney essence, for taste deficiency of qi and yin, lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, dry cough expectorant is few, polydipsia of quenching one's thirst, weakness of the spleen and stomach, deficiency of spleen-QI or deficiency of spleen-YIN, quenching one's thirst of yin asthenia generating intrinsic heat, the card such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.

Rhizoma Dioscoreae: sweet, flat, enters spleen, lung, kidney channel.Spleen benefiting and stimulating the appetite, boosting qi and nourishing yin, antidiarrheal arresting seminal emission.Cure mainly diarrhea due to hypofunction of the spleen, asthenia chronic cough, the diseases such as seminal emission, leukorrhagia frequent micturition of quenching one's thirst.

Radix potentillae anserinae: sweet is flat.Fill blood, strengthening the spleen and stomach, promoting the production of body fluid to quench thirst, dampness removing.For anemia after being ill, malnutrition, insufficiency of the spleen diarrhoea, rheumatic arthralgia.

Radix Ophiopogonis: sweet; Micro-hardship; Cold.Return lung; Stomach; Heart channel.Nourishing YIN and moistening the lung; Reinforcing stomach reg fluid; Clear away heart-fire relieving restlessness.Main dryness of the lung dry cough; Lung abscess; Deficiency of YIN chronic cough; Tianjin wound is thirsty; Quench one's thirst; Vexed insomnia; Have sore throat; Dryness of the intestine constipation; Heat in blood tells nosebleed.

Rhizoma Atractylodis: nature and flavor are pungent, bitter, temperature.Return spleen, stomach, Liver Channel.Expelling wind and removing dampness, antalgic, removing dampness leukorrhagia stopping." pearl sac " day: " stomach invigorating can pacify spleen, non-this of all damp-edema can not remove." Compendium of Material Medica says: " control damp-phlegm prolonged fluid-retention ... and spleen wets dirty, turbid drop leukorrhagia, slides and rushes down hemorrhoidal hamorrhage." " Newly Revised Canon of Materia Medica " claim it can " diuresis ".Cure mainly: the transporting imbalance that the spleen being blocked by dampness causes, inappetence, vomiting is unhappy, and abdominal distention is had loose bowels, arthralgia.For dampness taste, distension and fullness in the abdomen, cold-damp leucorrhea, damp-warm diseases and damp invasion of lower energizer, foot swelling and pain in knee, flaccidity are soft unable.

Radix Platycodonis: bitter in the mouth, pungent, property is put down.Return lung meridian.There is lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, effect of filling blood, mending five kinds of over strain, foster the spirit of nobility.Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.

Rhizoma Pleiones Yunnanensis: bitter is flat.Tonifying the lung, relieving cough and resolving phlegm, hemostasia and promoting granulation.Control silicosis, pulmonary tuberculosis, pertussis, tracheitis, digestive tract hemorrhage, carbuncle, traumatic hemorrhage.

Fructus Momordicae: sweet in the mouth; Cool in nature.Return lung; Spleen channel.Removing heat from the lung and relieving sorethroat; Preventing phlegm from forming and stopping coughing; Loosening bowel to relieve constipation.The cough of main lung-heat expectorant inflammation; Pharyngolaryngitis; Flatly choose body inflammation; Acute gastritis; Constipation.

The Radix Stemonae: nature and flavor are sweet, bitter, tepor.Return lung meridian." the southern regions of the Yunnan Province book on Chinese herbal medicine " records it: " lung moistening, controls cough due to lung-heat; Sputum eliminating to stop asthma, only chronic consumptive disease cough, parasite killing ".There is nourishing the lung to arrest cough, effect of parasite killing delousing.Main new chronic cough is coughed, pulmonary tuberculosis, pertussis, enterobiasis, body louse, tinea scabies.

Radix Asteris: warm in nature, bitter in the mouth, pungent." Bencao Jingshu ": " Radix Asteris, sees it and can open sore throat, get evil saliva, then pungent loose achievements; and it is warm in nature, and pneumonopathy cough with dyspnea is breathed heavily and is coughed, and all deficiency of YIN lung-heat syndrome is also; unsuitable special and multiplex, namely with also joining use with the medicine of Radix Asparagi, the Radix Stemonae, Radix Ophiopogonis, Cortex Mori bitter cold, then harmless." nourishing the lung to keep the adverse QI downward, preventing phlegm from forming and stopping coughing.Main cough, deficiency of the lung chronic cough, consumptive lung disease lung abscess, coughs vomiting bloody pus, dysuria.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 spray of the present invention

Get Fructus Gardeniae 25g, Radix Trichosanthis 30g, Rhizoma Imperatae 22g, Flos Lonicerae 30g, Herba Taraxaci 20g, Ilex purpurea Hassk.[I.chinensis Sims 15g, Herba Houttuyniae 15g, Radix Glycyrrhizae 10g, Rhizoma Polygoni Cuspidati 16g, Herba Sedi 11g, Commeline communis 14g, Radix Bupleuri 12g, Semen Cassiae Occidemtalis 14g, Pheretima 12g, Semen Lepidii (Semen Descurainiae) 13g, Folium Isatidis 8g, Radix Isatidis 8g, Rhizoma Osmundae 6g, Rhizoma Polygonati Odorati 18g, Rhizoma Polygonati 15g, Rhizoma Dioscoreae 15g, Radix potentillae anserinae 16g, Radix Ophiopogonis 20g, Rhizoma Atractylodis 15g, Radix Platycodonis 12g, Rhizoma Pleiones Yunnanensis 18g, Fructus Momordicae 15g, Radix Stemonae 20g and Radix Asteris 12g.

Its preparation method comprises the following steps:

A, take all raw medicinal materials in described ratio, add the water soaking 10 hours relative to the mixture quality 3 times obtained, after intense fire boils, using slow fire instead, to decoct the 30 minutes dosage to medicinal liquid be slowly 300ml, decocts 3 times, merges decoction liquor and filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;

B, the medicinal residues of step a are added 60% soak with ethanol 1.5 hours, extract twice, each 1 hour, merge extractive liquid, 160 orders filter, 10000 revs/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;

C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.

Embodiment 2 is of the present invention containing tablet

Get Fructus Gardeniae 23g, Radix Trichosanthis 36g, Rhizoma Imperatae 20g, Flos Lonicerae 35g, Herba Taraxaci 23g, Ilex purpurea Hassk.[I.chinensis Sims 14g, Herba Houttuyniae 16g, Radix Glycyrrhizae 13g, Rhizoma Polygoni Cuspidati 15g, Herba Sedi 14g, Commeline communis 16g, Radix Bupleuri 11g, Semen Cassiae Occidemtalis 13g, Pheretima 13g, Semen Lepidii (Semen Descurainiae) 11g, Folium Isatidis 7g, Radix Isatidis 9g, Rhizoma Osmundae 5g, Rhizoma Polygonati Odorati 19g, Rhizoma Polygonati 14g, Rhizoma Dioscoreae 16g, Radix potentillae anserinae 14g, Radix Ophiopogonis 18g, Rhizoma Atractylodis 14g, Radix Platycodonis 15g, Rhizoma Pleiones Yunnanensis 19g, Fructus Momordicae 13g, Radix Stemonae 23g and Radix Asteris 11g.

Its preparation method comprises the following steps:

The first step, by ratio mixing described in Radix Glycyrrhizae, Rhizoma Imperatae, Rhizoma Polygonati Odorati, Rhizoma Polygonati, Rhizoma Dioscoreae, Radix potentillae anserinae and Radix Ophiopogonis, by the soak with ethanol of the determining alcohol 95% of 5 times relative to the mixture quality obtained, reflux was extracted after 3 hours, filtered; By filtering residue again by the soak with ethanol of the determining alcohol 95% of 3 times relative to the mixture quality obtained, reflux was extracted after 1 hour, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, Rhizoma Atractylodis, Radix Platycodonis, Rhizoma Pleiones Yunnanensis, Fructus Momordicae, the Radix Stemonae and Radix Asteris are mixed in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 95% of 3 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 70 DEG C 60 DEG C, relative density is the mastic of 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water soaking of 3 times relative to the mixture quality obtained, and heating decoction 3 hours, filters; By filtering residue again with the water soaking of 1 times relative to the mixture quality obtained, heating decoction 1 hour, filters; Merge twice filtrate, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the carboxymethyl starch sodium of mixture quality 0.1 times, the microcrystalline Cellulose of 0.1 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.05 times obtained, then with decompressor by granule tabletted, obtain containing tablet.

Embodiment 3 granule of the present invention

Get Fructus Gardeniae 30g, Radix Trichosanthis 28g, Rhizoma Imperatae 26g, Flos Lonicerae 28g, Herba Taraxaci 18g, Ilex purpurea Hassk.[I.chinensis Sims 18g, Herba Houttuyniae 13g, Radix Glycyrrhizae 9g, Rhizoma Polygoni Cuspidati 18g, Herba Sedi 10g, Commeline communis 13g, Radix Bupleuri 14g, Semen Cassiae Occidemtalis 16g, Pheretima 10g, Semen Lepidii (Semen Descurainiae) 14g, Folium Isatidis 10g, Radix Isatidis 6g, Rhizoma Osmundae 8g, Rhizoma Polygonati Odorati 16g, Rhizoma Polygonati 17g, Rhizoma Dioscoreae 13g, Radix potentillae anserinae 19g, Radix Ophiopogonis 18g, Rhizoma Atractylodis 17g, Radix Platycodonis 11g, Rhizoma Pleiones Yunnanensis 169g, Fructus Momordicae 14g, Radix Stemonae 18g and Radix Asteris 15g.

Its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 95%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 DEG C subsequently under vacuum 0.07Mpa, relative density is the mastic of 1.06, spraying dry, the inlet temperature 175 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.1 times in the dried cream powder obtained, makes granule, in 50 DEG C of dryings, obtains granule.

Toxicity test:

Acute toxicity test: application NIH mice 60, SPF level, male and female half and half, body weight 17 ~ 24g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; Granule prepared by embodiments of the invention 3 is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage granule LD50>28.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage Chinese medicine of the present invention is 745 times of quantity.Therefore the granule acute toxicity of the embodiment of the present invention 3 is low, clinical drug safety.

Long term toxicity test: the spray of the embodiment of the present invention 1 is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Long term toxicity test: the tablet that contains of the embodiment of the present invention 2 is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: be selected from wind-heat invading lung type lobar pneumonia patient totally 184 examples that my institute accepts for medical treatment for 2012 to 2013, wherein male 88 example, women 96 example, minimum 26 months of age, maximum 49 years old.All patients are all diagnosed as lobar pneumonia after I institute chest X line, routine blood test, Sputum smears and mycoplasma pneumoniae antibody etc. check; .Be divided into four groups at random, four groups of no significant difference (P > 0.05), have comparability.

Aerosol therapy group: 46 people, male 22 people, female 24 people.

Containing tablet treatment group: 46 people, male 22 people, female 24 people.

Granules in Treating group: 46 people, male 22 people, female 24 people.

Western medicine group: 46 people, male 22 people, female 24 people.

Diagnostic criteria:

Clinical manifestation goes out cough, heating and tachypnea;

Physical examination result shows its pulmonary's respiratory murmur and occurs increasing thick phenomenon, auscultation of lung audible and wet sound of trembling, and local respiratory murmur presents reducing tendency, shows voiced sound or flatness to after lesions position percussion;

Chest X ray examination is carried out to it, inside the result display lobe of the lung, shows homogeneous consolidation image.

Diagnosis basis with reference to " Chinese medical disease Standardization of diagnosis and curative effect " wind-warm lung-heat disease:

Wind-heat invading lung type: fever without sweat or hypohidrosis, micro evil wind is trembled with fear, and cough expectorant is few, and headache, mouth is yearningly micro-.Tongue tip side of red, white and thin fur, floating and rapid pulse.

Allly meet above-mentioned clinical criteria and be diagnosed as lobar pneumonia, Chinese medical discrimination meets wind-heat invading lung type.

Therapeutic Method:

Aerosol therapy group: use spray prepared by the embodiment of the present invention 1, every day 3 times, each spray 3 times 5 days is 1 course for the treatment of.

Containing tablet treatment group: that takes the embodiment of the present invention 2 preparation contains tablet, and every day 3 times, each 45 days is 1 course for the treatment of.

Granules in Treating group: take granule prepared by the embodiment of the present invention 3, every day 3 times, each 1 bag 5 days is 1 course for the treatment of.

Western medicine group: penicillin 800,000 unit, intramuscular injection, 2 times on the 1st or 1,200 ten thousand units, quiet; Streptomycin 0. 5g intramuscular injection, 2 times on the 1st; It within 1 week, is 1 course for the treatment of.If apply above-mentioned antibiotic 3 days, body temperature does not decline, and symptom, sign, without improvement, use other antibiotic instead, as cephalexin, ampicillin, erythromycin or select sensitive antibiotic, conventional amount used.

Efficacy assessment standard:

Recovery from illness: clinical symptoms, sign disappear, and body temperature is down to normally, blood leukocytes sum and neutrophilic granulocyte are down to normally, and x-ray lung sheet checks that focus absorbs;

Effective: clinical symptoms, sign disappear or major part disappears (more than 2/3), blood leukocytes sum and neutrophilic granulocyte are down to normally, and x-ray checks that focus major part (more than 2/3) absorbs;

Effective: clinical symptoms, sign partial disappearance (more than 1/2), blood leukocytes sum and neutrophilic granulocyte are down to normal or close to normal, x-ray checks that focal part absorbs (more than 1/2);

Invalid: clinical symptoms, sign, blood leukocytes sum and neutrophilic granulocyte, x-ray inspection are all not improved or increase the weight of.

Therapeutic outcome:

See table 1 and table 2, as can be seen from Table 1, adopt treatment by Chinese herbs wind-heat invading lung type lobar pneumonia of the present invention, relative to Western medicine on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt treatment by Chinese herbs wind-heat invading lung type lobar pneumonia of the present invention, relative to Western medicine, treatment the course for the treatment of on significantly shorten.

Table 1 Four composition does not treat Clinical efficacy comparison example after 10 days

Group	Number of cases	Recovery from illness	Effective	Effectively	Invalid	Total effective rate
							Aerosol therapy group	46	36	6	4	0	100%
Containing tablet treatment group	46	35	7	3	1	97.8%
							Granules in Treating group	46	35	8	3	0	100%
Western medicine group	46	32	5	5	4	91.3%

Table 2 Four composition does not treat 10 days recovery from illness, effective and effective number and time comparative examples (%) afterwards

Group	Number of cases	1-5 days	6-10 days
				Aerosol therapy group	46	29(63.0%)	17(37.0%)
Containing tablet treatment group	45	27(60.0%)	18(40.0%)
				Granules in Treating group	46	28(60.9%)	18(39.1)
Western medicine group	42	20(47.6%)	22(52.4%)

According to the clinical statistics in above table, Chinese medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect.

Model case:

Patient Zhang, female, 36 years old, in February, 2013 went to a doctor, and main suit's left chest pain heating, cough and be admitted to hospital for 1 day, fever, headache, shiver with cold, left chest pain, hypohidrosis, thin white fur of tongue, floating and rapid pulse, breast body is looked into: left pulmonary respiration weakens, body temperature 40.5 DEG C, leukocyte 15700.X-ray examination: left lung field inside middle portion has lamellar density to increase shade.Diagnosis: be lobus sinister lobar pneumonia.Chinese medical discrimination wind-heat invading lung type.Use the spray of Chinese medicine preparation embodiment 1 of the present invention, every day 3 times, each spray 3 times, after 3 days, cough symptom obviously alleviates, and within 6 days, substantially disappears afterwards.But still have cough after activity, play amount of expectoration morning and obviously reduce, continue use recovery from illness in 2 days.Advise its warming, follow up a case by regular visits to and do not recur for 1 year.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. treat the Chinese medicine of wind-heat invading lung type lobar pneumonia for one kind, it is characterized in that, comprise following raw medicinal material: Fructus Gardeniae, Radix Trichosanthis, Rhizoma Imperatae, Flos Lonicerae, Herba Taraxaci, Ilex purpurea Hassk.[I.chinensis Sims, Herba Houttuyniae, Radix Glycyrrhizae, Rhizoma Polygoni Cuspidati, Herba Sedi, Commeline communis, Radix Bupleuri, Semen Cassiae Occidemtalis, Pheretima, Semen Lepidii (Semen Descurainiae), Folium Isatidis, Radix Isatidis, Rhizoma Osmundae, Rhizoma Polygonati Odorati, Rhizoma Polygonati, Rhizoma Dioscoreae, Radix potentillae anserinae, Radix Ophiopogonis, Rhizoma Atractylodis, Radix Platycodonis, Rhizoma Pleiones Yunnanensis, Fructus Momordicae, the Radix Stemonae and Radix Asteris.

2. Chinese medicine according to claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Fructus Gardeniae 22-32 part, Radix Trichosanthis 26-39 part, Rhizoma Imperatae 20-30 part, Flos Lonicerae 28-38 part, Herba Taraxaci 16-25 part, Ilex purpurea Hassk.[I.chinensis Sims 12-21 part, Herba Houttuyniae 11-19 part, Radix Glycyrrhizae 9-15 part, Rhizoma Polygoni Cuspidati 13-20 part, Herba Sedi 10-16 part, Commeline communis 12-17 part, Radix Bupleuri 10-15 part, Semen Cassiae Occidemtalis 12-16 part, Pheretima 8-14 part, Semen Lepidii (Semen Descurainiae) 10-15 part, Folium Isatidis 6-12 part, Radix Isatidis 6-11 part, Rhizoma Osmundae 5-9 part, Rhizoma Polygonati Odorati 14-20 part, Rhizoma Polygonati 13-19 part, Rhizoma Dioscoreae 12-16 part, Radix potentillae anserinae 14-21 part, Radix Ophiopogonis 17-27 part, Rhizoma Atractylodis 12-17 part, Radix Platycodonis 11-16 part, Rhizoma Pleiones Yunnanensis 16-20 part, Fructus Momordicae 13-16 part, Radix Stemonae 15-25 part and Radix Asteris 10-18 part.

3. Chinese medicine according to claim 1 and 2, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Fructus Gardeniae 23-30 part, Radix Trichosanthis 28-36 part, Rhizoma Imperatae 20-26 part, Flos Lonicerae 28-35 part, Herba Taraxaci 18-23 part, Ilex purpurea Hassk.[I.chinensis Sims 14-18 part, Herba Houttuyniae 13-16 part, Radix Glycyrrhizae 9-13 part, Rhizoma Polygoni Cuspidati 15-18 part, Herba Sedi 10-14 part, Commeline communis 13-16 part, Radix Bupleuri 11-14 part, Semen Cassiae Occidemtalis 13-16 part, Pheretima 10-13 part, Semen Lepidii (Semen Descurainiae) 11-14 part, Folium Isatidis 7-10 part, Radix Isatidis 6-9 part, Rhizoma Osmundae 5-8 part, Rhizoma Polygonati Odorati 16-19 part, Rhizoma Polygonati 14-17 part, Rhizoma Dioscoreae 13-16 part, Radix potentillae anserinae 14-19 part, Radix Ophiopogonis 18-23 part, Rhizoma Atractylodis 14-17 part, Radix Platycodonis 11-15 part, Rhizoma Pleiones Yunnanensis 16-19 part, Fructus Momordicae 13-15 part, Radix Stemonae 18-23 part and Radix Asteris 11-15 part.

4. according to the arbitrary described Chinese medicine of claim 1-3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Fructus Gardeniae 25 parts, Radix Trichosanthis 30 parts, Rhizoma Imperatae 22 parts, Flos Lonicerae 30 parts, Herba Taraxaci 20 parts, Ilex purpurea Hassk.[I.chinensis Sims 15 parts, Herba Houttuyniae 15 parts, Radix Glycyrrhizae 10 parts, Rhizoma Polygoni Cuspidati 16 parts, Herba Sedi 11 parts, Commeline communis 14 parts, Radix Bupleuri 12 parts, Semen Cassiae Occidemtalis 14 parts, Pheretima 12 parts, Semen Lepidii (Semen Descurainiae) 13 parts, Folium Isatidis 8 parts, Radix Isatidis 8 parts, Rhizoma Osmundae 6 parts, Rhizoma Polygonati Odorati 18 parts, Rhizoma Polygonati 15 parts, Rhizoma Dioscoreae 15 parts, Radix potentillae anserinae 16 parts, Radix Ophiopogonis 20 parts, Rhizoma Atractylodis 15 parts, Radix Platycodonis 12 parts, Rhizoma Pleiones Yunnanensis 18 parts, Fructus Momordicae 15 parts, the Radix Stemonae 20 parts and Radix Asteris 12 parts.

5. according to the arbitrary described Chinese medicine of claim 1-3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Fructus Gardeniae 23 parts, Radix Trichosanthis 36 parts, Rhizoma Imperatae 20 parts, Flos Lonicerae 35 parts, Herba Taraxaci 23 parts, Ilex purpurea Hassk.[I.chinensis Sims 14 parts, Herba Houttuyniae 16 parts, Radix Glycyrrhizae 13 parts, Rhizoma Polygoni Cuspidati 15 parts, Herba Sedi 14 parts, Commeline communis 16 parts, Radix Bupleuri 11 parts, Semen Cassiae Occidemtalis 13 parts, Pheretima 13 parts, Semen Lepidii (Semen Descurainiae) 11 parts, Folium Isatidis 7 parts, Radix Isatidis 9 parts, Rhizoma Osmundae 5 parts, Rhizoma Polygonati Odorati 19 parts, Rhizoma Polygonati 14 parts, Rhizoma Dioscoreae 16 parts, Radix potentillae anserinae 14 parts, Radix Ophiopogonis 18 parts, Rhizoma Atractylodis 14 parts, Radix Platycodonis 15 parts, Rhizoma Pleiones Yunnanensis 19 parts, Fructus Momordicae 13 parts, the Radix Stemonae 23 parts and Radix Asteris 11 parts.

6. according to the arbitrary described Chinese medicine of claim 1-3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Fructus Gardeniae 30 parts, Radix Trichosanthis 28 parts, Rhizoma Imperatae 26 parts, Flos Lonicerae 28 parts, Herba Taraxaci 18 parts, Ilex purpurea Hassk.[I.chinensis Sims 18 parts, Herba Houttuyniae 13 parts, Radix Glycyrrhizae 9 parts, Rhizoma Polygoni Cuspidati 18 parts, Herba Sedi 10 parts, Commeline communis 13 parts, Radix Bupleuri 14 parts, Semen Cassiae Occidemtalis 16 parts, Pheretima 10 parts, Semen Lepidii (Semen Descurainiae) 14 parts, Folium Isatidis 10 parts, Radix Isatidis 6 parts, Rhizoma Osmundae 8 parts, Rhizoma Polygonati Odorati 16 parts, Rhizoma Polygonati 17 parts, Rhizoma Dioscoreae 13 parts, Radix potentillae anserinae 19 parts, Radix Ophiopogonis 18 parts, Rhizoma Atractylodis 17 parts, Radix Platycodonis 11 parts, Rhizoma Pleiones Yunnanensis 169 parts, Fructus Momordicae 14 parts, the Radix Stemonae 18 parts and Radix Asteris 15 parts.

7., according to the arbitrary described Chinese medicine of claim 1-6, it is characterized in that, when the dosage form of described Chinese medicine is spray, its preparation method comprises the following steps:

C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.

8. according to the arbitrary described Chinese medicine of claim 1-6, it is characterized in that, the dosage form of described Chinese medicine is for during containing tablet, and its preparation method comprises the following steps:

9., according to the arbitrary described Chinese medicine of claim 1-6, it is characterized in that, when the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps: