CN104367942A - Traditional Chinese medicine for treating lobar pneumonia with syndrome of phlegm-heat obstructing lung in children and preparation method - Google Patents
Traditional Chinese medicine for treating lobar pneumonia with syndrome of phlegm-heat obstructing lung in children and preparation method Download PDFInfo
- Publication number
- CN104367942A CN104367942A CN201410613643.3A CN201410613643A CN104367942A CN 104367942 A CN104367942 A CN 104367942A CN 201410613643 A CN201410613643 A CN 201410613643A CN 104367942 A CN104367942 A CN 104367942A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- herba
- chinese medicine
- rhizoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 67
- 210000004072 lung Anatomy 0.000 title claims abstract description 66
- 206010062717 Increased upper airway secretion Diseases 0.000 title claims abstract description 43
- 208000026435 phlegm Diseases 0.000 title claims abstract description 43
- 206010035664 Pneumonia Diseases 0.000 title claims abstract description 35
- 208000032923 Lobar pneumonia Diseases 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 208000011580 syndromic disease Diseases 0.000 title abstract description 7
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims abstract description 19
- 235000006226 Areca catechu Nutrition 0.000 claims abstract description 19
- 210000000582 semen Anatomy 0.000 claims abstract description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 36
- 239000000203 mixture Substances 0.000 claims description 23
- 241000723353 Chrysanthemum Species 0.000 claims description 20
- 235000007516 Chrysanthemum Nutrition 0.000 claims description 20
- 244000060234 Gmelina philippensis Species 0.000 claims description 20
- 235000021506 Ipomoea Nutrition 0.000 claims description 20
- 241000207783 Ipomoea Species 0.000 claims description 20
- 239000000463 material Substances 0.000 claims description 19
- 244000235603 Acacia catechu Species 0.000 claims description 18
- 241000255791 Bombyx Species 0.000 claims description 18
- 241000180649 Panax notoginseng Species 0.000 claims description 18
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 18
- 241000195474 Sargassum Species 0.000 claims description 18
- 239000007921 spray Substances 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 11
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 9
- 238000000108 ultra-filtration Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 4
- 238000002791 soaking Methods 0.000 claims description 3
- 239000006228 supernatant Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 13
- 206010007247 Carbuncle Diseases 0.000 abstract description 8
- 230000017531 blood circulation Effects 0.000 abstract description 7
- 231100000331 toxic Toxicity 0.000 abstract description 6
- 230000002588 toxic effect Effects 0.000 abstract description 6
- 230000035876 healing Effects 0.000 abstract description 5
- 239000003053 toxin Substances 0.000 abstract description 4
- 231100000765 toxin Toxicity 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 244000080767 Areca catechu Species 0.000 abstract 1
- 235000015759 Artemisia selengensis Nutrition 0.000 abstract 1
- 241001168877 Artemisia selengensis Species 0.000 abstract 1
- 241001474374 Blennius Species 0.000 abstract 1
- 241000255789 Bombyx mori Species 0.000 abstract 1
- 235000014375 Curcuma Nutrition 0.000 abstract 1
- 244000164480 Curcuma aromatica Species 0.000 abstract 1
- 240000009138 Curcuma zedoaria Species 0.000 abstract 1
- 235000003405 Curcuma zedoaria Nutrition 0.000 abstract 1
- 241000594402 Damnacanthus Species 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 240000001549 Ipomoea eriocarpa Species 0.000 abstract 1
- 235000005146 Ipomoea eriocarpa Nutrition 0.000 abstract 1
- 229930195210 Ophiopogon Natural products 0.000 abstract 1
- 244000248557 Ophiopogon japonicus Species 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 235000003181 Panax pseudoginseng Nutrition 0.000 abstract 1
- 244000273256 Phragmites communis Species 0.000 abstract 1
- 235000014676 Phragmites communis Nutrition 0.000 abstract 1
- 244000197580 Poria cocos Species 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 244000081923 Rumex patientia Species 0.000 abstract 1
- 235000008330 Rumex patientia Nutrition 0.000 abstract 1
- 240000004274 Sarcandra glabra Species 0.000 abstract 1
- 235000010842 Sarcandra glabra Nutrition 0.000 abstract 1
- 244000111146 Sonchus arvensis Species 0.000 abstract 1
- 235000008135 Sonchus arvensis ssp. arvensis Nutrition 0.000 abstract 1
- 235000008132 Sonchus arvensis ssp. uliginosus Nutrition 0.000 abstract 1
- 241000009298 Trigla lyra Species 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 abstract 1
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 abstract 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 abstract 1
- 235000019509 white turmeric Nutrition 0.000 abstract 1
- 206010011224 Cough Diseases 0.000 description 38
- 238000011282 treatment Methods 0.000 description 32
- 239000008280 blood Substances 0.000 description 30
- 210000004369 blood Anatomy 0.000 description 29
- 239000000843 powder Substances 0.000 description 20
- 230000001717 pathogenic effect Effects 0.000 description 19
- 241000699670 Mus sp. Species 0.000 description 13
- 201000010099 disease Diseases 0.000 description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 13
- 231100000614 poison Toxicity 0.000 description 13
- 239000003440 toxic substance Substances 0.000 description 13
- 239000008187 granular material Substances 0.000 description 12
- 230000001737 promoting effect Effects 0.000 description 12
- 239000006188 syrup Substances 0.000 description 12
- 235000020357 syrup Nutrition 0.000 description 12
- 208000002193 Pain Diseases 0.000 description 10
- 235000009508 confectionery Nutrition 0.000 description 10
- 229940079593 drug Drugs 0.000 description 10
- 210000000952 spleen Anatomy 0.000 description 10
- 239000000243 solution Substances 0.000 description 9
- 230000003203 everyday effect Effects 0.000 description 8
- 238000005325 percolation Methods 0.000 description 8
- 230000002685 pulmonary effect Effects 0.000 description 8
- 238000010992 reflux Methods 0.000 description 8
- 210000002784 stomach Anatomy 0.000 description 8
- 238000002560 therapeutic procedure Methods 0.000 description 8
- 206010036790 Productive cough Diseases 0.000 description 7
- 230000037396 body weight Effects 0.000 description 7
- 210000004185 liver Anatomy 0.000 description 7
- 244000052769 pathogen Species 0.000 description 7
- 231100000419 toxicity Toxicity 0.000 description 7
- 230000001988 toxicity Effects 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 6
- 229930006000 Sucrose Natural products 0.000 description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 6
- 208000033809 Suppuration Diseases 0.000 description 6
- 230000002421 anti-septic effect Effects 0.000 description 6
- 239000006071 cream Substances 0.000 description 6
- 208000001780 epistaxis Diseases 0.000 description 6
- 201000003453 lung abscess Diseases 0.000 description 6
- 239000013521 mastic Substances 0.000 description 6
- 231100000915 pathological change Toxicity 0.000 description 6
- 230000036285 pathological change Effects 0.000 description 6
- 208000037920 primary disease Diseases 0.000 description 6
- 229960004793 sucrose Drugs 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 206010008479 Chest Pain Diseases 0.000 description 5
- 206010010774 Constipation Diseases 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 239000003172 expectorant agent Substances 0.000 description 5
- 230000003419 expectorant effect Effects 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 208000014674 injury Diseases 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 230000008736 traumatic injury Effects 0.000 description 5
- 241000193998 Streptococcus pneumoniae Species 0.000 description 4
- 230000036760 body temperature Effects 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 208000013116 chronic cough Diseases 0.000 description 4
- 210000002216 heart Anatomy 0.000 description 4
- 208000035861 hematochezia Diseases 0.000 description 4
- 230000023597 hemostasis Effects 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 239000012535 impurity Substances 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 210000000056 organ Anatomy 0.000 description 4
- 230000001047 pyretic effect Effects 0.000 description 4
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 4
- 239000005720 sucrose Substances 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- 230000035922 thirst Effects 0.000 description 4
- 208000006820 Arthralgia Diseases 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 3
- 208000000059 Dyspnea Diseases 0.000 description 3
- 206010013975 Dyspnoeas Diseases 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 206010027514 Metrorrhagia Diseases 0.000 description 3
- 206010030113 Oedema Diseases 0.000 description 3
- 206010033557 Palpitations Diseases 0.000 description 3
- 208000004880 Polyuria Diseases 0.000 description 3
- 206010037549 Purpura Diseases 0.000 description 3
- 241001672981 Purpura Species 0.000 description 3
- 206010043458 Thirst Diseases 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 210000001015 abdomen Anatomy 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000000443 aerosol Substances 0.000 description 3
- 208000006673 asthma Diseases 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 230000013872 defecation Effects 0.000 description 3
- 230000035619 diuresis Effects 0.000 description 3
- 238000001647 drug administration Methods 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 239000003337 fertilizer Substances 0.000 description 3
- 238000003304 gavage Methods 0.000 description 3
- 208000006454 hepatitis Diseases 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000009545 invasion Effects 0.000 description 3
- 230000003902 lesion Effects 0.000 description 3
- 210000000265 leukocyte Anatomy 0.000 description 3
- 201000007227 lymph node tuberculosis Diseases 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- 238000010791 quenching Methods 0.000 description 3
- 206010037833 rales Diseases 0.000 description 3
- 230000000241 respiratory effect Effects 0.000 description 3
- 239000002689 soil Substances 0.000 description 3
- 208000024794 sputum Diseases 0.000 description 3
- 210000003802 sputum Anatomy 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 2
- 206010013908 Dysfunctional uterine bleeding Diseases 0.000 description 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- 206010017553 Furuncle Diseases 0.000 description 2
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 206010068319 Oropharyngeal pain Diseases 0.000 description 2
- 229930182555 Penicillin Natural products 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- 201000007100 Pharyngitis Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 244000173166 Pyrus ussuriensis Species 0.000 description 2
- 235000011572 Pyrus ussuriensis Nutrition 0.000 description 2
- 208000037656 Respiratory Sounds Diseases 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 208000005392 Spasm Diseases 0.000 description 2
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 2
- 238000011047 acute toxicity test Methods 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000002513 anti-ovulatory effect Effects 0.000 description 2
- 230000006399 behavior Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000009534 blood test Methods 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 210000000038 chest Anatomy 0.000 description 2
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000006735 deficit Effects 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 2
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000000416 exudates and transudate Anatomy 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 231100000283 hepatitis Toxicity 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 206010022000 influenza Diseases 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 238000010255 intramuscular injection Methods 0.000 description 2
- 239000007927 intramuscular injection Substances 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 230000003908 liver function Effects 0.000 description 2
- 231100001252 long-term toxicity Toxicity 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 239000002547 new drug Substances 0.000 description 2
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 description 2
- 230000007918 pathogenicity Effects 0.000 description 2
- 229940049954 penicillin Drugs 0.000 description 2
- 229940069338 potassium sorbate Drugs 0.000 description 2
- 235000010241 potassium sorbate Nutrition 0.000 description 2
- 239000004302 potassium sorbate Substances 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000001291 vacuum drying Methods 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- MCSXGCZMEPXKIW-UHFFFAOYSA-N 3-hydroxy-4-[(4-methyl-2-nitrophenyl)diazenyl]-N-(3-nitrophenyl)naphthalene-2-carboxamide Chemical compound Cc1ccc(N=Nc2c(O)c(cc3ccccc23)C(=O)Nc2cccc(c2)[N+]([O-])=O)c(c1)[N+]([O-])=O MCSXGCZMEPXKIW-UHFFFAOYSA-N 0.000 description 1
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 206010049244 Ankyloglossia congenital Diseases 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- 208000004429 Bacillary Dysentery Diseases 0.000 description 1
- 239000003390 Chinese drug Substances 0.000 description 1
- 206010008909 Chronic Hepatitis Diseases 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010012218 Delirium Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 206010017915 Gastroenteritis shigella Diseases 0.000 description 1
- 206010018498 Goitre Diseases 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000008017 Hypohidrosis Diseases 0.000 description 1
- 208000015817 Infant Nutrition disease Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 201000008197 Laryngitis Diseases 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 208000005647 Mumps Diseases 0.000 description 1
- 206010062575 Muscle contracture Diseases 0.000 description 1
- 241000202934 Mycoplasma pneumoniae Species 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010030302 Oliguria Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 208000032023 Signs and Symptoms Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 208000003028 Stuttering Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000005946 Xerostomia Diseases 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000038016 acute inflammation Diseases 0.000 description 1
- 230000006022 acute inflammation Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000001986 anti-endotoxic effect Effects 0.000 description 1
- 230000001166 anti-perspirative effect Effects 0.000 description 1
- 239000003213 antiperspirant Substances 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 238000002555 auscultation Methods 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000003123 bronchiole Anatomy 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 230000004856 capillary permeability Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 description 1
- 229940106164 cephalexin Drugs 0.000 description 1
- 208000019065 cervical carcinoma Diseases 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- -1 clean ancient mycin Chemical compound 0.000 description 1
- 229940121657 clinical drug Drugs 0.000 description 1
- 229960004126 codeine Drugs 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000007596 consolidation process Methods 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 208000006111 contracture Diseases 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 208000017574 dry cough Diseases 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 229960003276 erythromycin Drugs 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 201000003872 goiter Diseases 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 201000007772 internal hemorrhoid Diseases 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 210000005087 mononuclear cell Anatomy 0.000 description 1
- 208000010805 mumps infectious disease Diseases 0.000 description 1
- 210000001989 nasopharynx Anatomy 0.000 description 1
- 201000008383 nephritis Diseases 0.000 description 1
- 230000003448 neutrophilic effect Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000003305 oral gavage Methods 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 238000009527 percussion Methods 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 208000008423 pleurisy Diseases 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 208000010707 pulmonary consolidation Diseases 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 201000004193 respiratory failure Diseases 0.000 description 1
- 230000004202 respiratory function Effects 0.000 description 1
- 210000003019 respiratory muscle Anatomy 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 201000005113 shigellosis Diseases 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 208000008203 tachypnea Diseases 0.000 description 1
- 206010043089 tachypnoea Diseases 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine for treating lobar pneumonia with the syndrome of phlegm-heat obstructing lung in children and a preparation method. The traditional Chinese medicine is prepared from the following medicinal raw materials: ophiopogon root, rhizoma anemarrhenae, phragmites stem, artemisia selengensis turcz, takaikatzuchia lomonossowii, curcuma zedoary, indian damnacanthus herb, hungaian morning glory root, poria cocos, semen benincasae, radix asteris, silkworm larva, partedleaf violet herb, field sowthistle herb, sarcandra glabra, patience dock root, caulis pipers futokadsurae, pseudo-ginseng, seaweed, catechu and licorice root. The traditional Chinese medicine has the beneficial effects of clearing heat, eliminating stagnation, resolving toxin, expelling pus, lowering internal fire, dissolving turbidity, removing phlegm, activating blood circulation to remove stasis, eliminating stagnations of phlegm, stasis and heat-toxin, improving lung, eliminating stagnation and removing carbuncle, and is mainly used for treating lobar pneumonia with the syndrome of phlegm-heat obstructing lung in children. The traditional Chinese medicine has a simple and convenient preparation process and small toxic and side effect, is convenient to take and easy to prepare, is low in cost, and is capable of directly reaching the focus with short cure time and preventing relapse after healing.
Description
Technical field
The present invention relates to pharmaceutical technology, particularly a kind of Chinese medicine and preparation method for the treatment of child's phlegm-heat obstructing lung type lobar pneumonia.
Background technology
Pneumonia is Childhood especially infant commonly encountered diseases in period and frequently-occurring disease, occupies and threatens (pneumonia, suffers from diarrhoea, anemia, rickets) first of the healthy and large disease of life common four of Chinese children.Pneumonia accounts for the 28-34% of less than 5 years old death of child ratio in global range according to statistics.Often be close on 1.55 hundred million children (< year) to suffer from an inflammation of the lungs, wherein 1100-2000 ten thousand (7-13%) needs hospitalization, brings very big burden to medical industry.Lobar pneumonia is common community-acquired pneumonia in children, is the acute lung tissue inflammation that various pathogenic infection causes, and pathological changes distribution is confined to the lung tissue of more than a lung section more, can be great Ye, also can be segmental.Child's lobar pneumonia sickness rate rises gradually in recent years, along with the factors such as clinical laboratory's Examined effect raising, antibiotic extensive use and Resistant strain increase participate in, all there is many transformations in the aspect such as child's lobar pneumonia cause of disease, epidemic, Clinical symptom and sign, treatment, brings very large difficulty to clinician's diagnosis and treatment work.
Lobar pneumonia (lobarpneumonia) is mainly caused by streptococcus pneumoniae, and pathological changes involves an above lung tissue of lung section, the acute inflammation oozed out based on Diffuse fibrous element in alveolar.Pathological changes originates in local alveolar, and rapid spread to lung section or whole great Ye.Onset is hurried clinically, and Chang Yigao heat, aversion to cold start, and then occur chest pain, cough, cough rusty expectoration, dyspnea, and have pulmonary consolidation sign and leukocyte counts to increase.About one week of the course of disease, body temperature rapid drawdown, transference cure.This disease is multiple is born in male adults.The common inducement of disease is suffered from cold, tired or drench with rain.Belong to the category such as the traditional Chinese medical science " pathogenic wind-warm ", " lung abscess ".
The cause of disease
Various bacteria all can cause lobar pneumonia, but the overwhelming majority is streptococcus pneumoniae, wherein the strongest with III type pathogenicity.Streptococcus pneumoniae is gram-negative cocci, has pod membrane, and its pathogenicity is because the pod membrane of macromolecule polysaccharide body is to the invasion and attack effect of tissue.Minority is pneumobacillus, staphylococcus aureus, Hemolytic streptococcus, hemophilus influenza etc.Streptococcus pneumoniae is the normal parasitic flora of oral cavity and nasopharynx part, if when the resistance of the discharge of bacteria self-purification function of respiratory tract and body is normal, do not cause pneumonia.When body catch cold, overtired, drunk, flu, diabetes, immunologic hypofunction etc. make respiratory tract defense function weakened, antibacterial invades alveolar makes alveolar wall capillary permeability strengthen by allergy, serosity and cellulose ooze out, in rich protein-contg exudate, antibacterial breeds rapidly, and spread to contiguous lung tissue by interalveolar pores or alveolar bronchiole, involve a lung section or the whole lobe of the lung.The transudate spreading frenulum bacterium between great Ye is caused by the leaf bronchogenic spread.
Western medicine therapy
1, antibiotic therapy: penicillin, sulfonamides, erythromycin, clean ancient mycin, cephalexin number;
2, symptomatic treatment: (1) high hot person: aspirin, antondin; (2) chest pain is violent: oral codeine; (3) cough is coughed up phlegm: mixture of ammonium chloride; (4) water-electrolyte balance is kept.(5) respiratory failure of suffering a shock handles accordingly
Primary disease belongs to by Chinese medicine " breathing with cough ", " pulmonary distension ", the category such as " pathogenic wind-warm ".Think that primary disease is many in positive QI-insufficiency, when defending outer miopragia, caused by being invaded by exogenous pathogen.As Qing Dynasty's doctor's Ye Gui a, famous physician of the Qing Dynasty was once pointed out " warm pathogen tend to attack the upper orifices, attacking the lung first ".Namely the exopathogen such as pathogenic wind-warm invasion and attack human body, relates to lungs, produces a series of pathological change.Exopathogen both can be the heresy of wind heat, also can be the heresy of wind and cold, defends, make impaired depurative descending of lung QI and produce disease, also can pathogenic heat pent up in lung, or phlegm-damp staying in lung from the beginning of infringement lung.Primary disease is in evolution, and the friendship of generally just struggling against through heresy is striven, and often just can win heresy, and the card feelings of impairment of both QI and YIN can appear in the later stage.If vital QI cannot conquer pathogen, yang-energy can be formed for de-critical syndrome.
Chinese medical discrimination is divided into:
Syndrome of WEI system (heat defends type at lung), card is shown in: heating, and micro evil wind is trembled with fear, lossless or hypohidrosis, headache, and cough, xerostomia is yearningly micro-, tongue tip side of red white or yellow thin fur, floating and rapid pulse.
Syndrome in QI system (phlegm-heat obstructing lung type), card is shown in: high hot excessive thirst, cough, chest pain, coughs up yellow sputum or band blood, red tongue with yellow fur or greasy, slippery and rapid pulse or large.
The heart-nutriment card (battalion's Re Neisheng type or heat attacking the pericardium type), card is shown in: high hot dusk, very irritated, cough with asthma was out of breath, or delirium, coma, the stuttering cold of the limbs of tongue, deep red tongue, thready,rolling and rapid pulse.
But western medical treatment lobar pneumonia, the course for the treatment of is longer, and widely apply antibiotic for a long time, expectorant easily produces drug resistance, clinical efficacy is not satisfactory, and the easy recurrent exerbation of the state of an illness, has a strong impact on the quality of life etc. of patient.
But, Chinese medicine lobar pneumonia, possess unique advantage and feature: utilize Traditional Chinese medical theory, on the basis of Overall View, by regulating qi-blood circulating, enhancing human body immunity power, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, treat according to different disease Mutiple Targets, strengthen the respiratory function of respiratory muscle, promote expectoration cough-relieving, relieving asthma, keep respiratory passage unblocked, drug effect is gone directly focus, safe and effective, the course for the treatment of is shorter, and not easily produce drug resistance, cost price is lower, convenient drug administration, patient is easy to accept, cure rate can be significantly improved, reduce complication, reduce relapse rate, significantly improve the quality of life etc. of patient.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine and preparation method for the treatment of child's phlegm-heat obstructing lung type lobar pneumonia, the present invention has heat clearing away eliminating stagnation, effect of removing toxic substances and promoting pus discharge, hold concurrently and detoxify with pathogenic fire reducing, change turbid eliminating the phlegm, promoting blood circulation to remove blood stasis, the heap soil or fertilizer over and around the roots of solution expectorant, the stasis of blood, pyretic toxicity is stagnant, with suitable lung eliminating stagnation eliminating carbuncle, cure mainly phlegm-heat obstructing lung type lobar pneumonia; And processing technology is easy, the little and convenient drug administration of toxic and side effects, medicament is easy to manufacture, and new drug with low cost, focus of going directly, healing time is short, not easily recurs after healing.
In order to realize foregoing invention object, the invention provides a kind of Chinese medicine for the treatment of child's phlegm-heat obstructing lung type lobar pneumonia, wherein, following raw medicinal material is comprised: Radix Ophiopogonis, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, red Chen Ai, hedgehog chrysanthemum, Rhizoma Curcumae, Herba Damnacanthi, Ipomoea hungaiensis Lingelsh. Et Borza., Poria, Semen Benincasae, Radix Asteris, Bombyx Batryticatus, Herba Violae dissectae, Herba Sonchi Arvensis, Herba Sarcandrae, Radix Rumicis Patientiae, Caulis Piperis Kadsurae, Radix Notoginseng, Sargassum, Catechu and Radix Glycyrrhizae.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Ophiopogonis 20-30 part, Rhizoma Anemarrhenae 20-30 part, Rhizoma Phragmitis 15-20 part, red Chen Ai 6-9 part, hedgehog chrysanthemum 6-9 part, Rhizoma Curcumae 6-9 part, Herba Damnacanthi 15-25 part, Ipomoea hungaiensis Lingelsh. Et Borza. 15-25 part, Poria 6-12 part, Semen Benincasae 15-30 part, Radix Asteris 6-12 part, Bombyx Batryticatus 6-9 part, Herba Violae dissectae 10-15 part, Herba Sonchi Arvensis 6-12 part, Herba Sarcandrae 6-10 part, Radix Rumicis Patientiae 7-12 part, Caulis Piperis Kadsurae 6-9 part, Radix Notoginseng 15-19 part, Sargassum 10-15 part, Catechu 6-9 part and Radix Glycyrrhizae 5-10 part.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Ophiopogonis 25-30 part, Rhizoma Anemarrhenae 25-30 part, Rhizoma Phragmitis 16-20 part, red Chen Ai 6-8 part, hedgehog chrysanthemum 7-9 part, Rhizoma Curcumae 7-9 part, Herba Damnacanthi 15-23 part, Ipomoea hungaiensis Lingelsh. Et Borza. 15-20 part, Poria 8-12 part, Semen Benincasae 20-25 part, Radix Asteris 8-12 part, Bombyx Batryticatus 7-9 part, Herba Violae dissectae 10-15 part, Herba Sonchi Arvensis 6-11 part, Herba Sarcandrae 6-9 part, Radix Rumicis Patientiae 7-10 part, Caulis Piperis Kadsurae 6-8 part, Radix Notoginseng 16-19 part, Sargassum 11-15 part, Catechu 6-8 part and Radix Glycyrrhizae 5-8 part.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Ophiopogonis 25 parts, the Rhizoma Anemarrhenae 27 parts, Rhizoma Phragmitis 16 parts, red Chen Ai 6 parts, hedgehog chrysanthemum 9 parts, Rhizoma Curcumae 8 parts, Herba Damnacanthi 21 parts, Ipomoea hungaiensis Lingelsh. Et Borza. 16 parts, 10 parts, Poria, Semen Benincasae 20 parts, Radix Asteris 12 parts, Bombyx Batryticatus 7 parts, Herba Violae dissectae 12 parts, Herba Sonchi Arvensis 6 parts, Herba Sarcandrae 9 parts, Radix Rumicis Patientiae 7 parts, Caulis Piperis Kadsurae 8 parts, Radix Notoginseng 16 parts, Sargassum 15 parts, Catechu 6 parts and 8 parts, Radix Glycyrrhizae.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Ophiopogonis 30 parts, the Rhizoma Anemarrhenae 30 parts, Rhizoma Phragmitis 20 parts, red Chen Ai 7 parts, hedgehog chrysanthemum 8 parts, Rhizoma Curcumae 9 parts, Herba Damnacanthi 23 parts, Ipomoea hungaiensis Lingelsh. Et Borza. 15 parts, 8 parts, Poria, Semen Benincasae 25 parts, Radix Asteris 9 parts, Bombyx Batryticatus 8 parts, Herba Violae dissectae 15 parts, Herba Sonchi Arvensis 11 parts, Herba Sarcandrae 7 parts, Radix Rumicis Patientiae 8 parts, Caulis Piperis Kadsurae 7 parts, Radix Notoginseng 17 parts, Sargassum 11 parts, Catechu 7 parts and 6 parts, Radix Glycyrrhizae.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Ophiopogonis 28 parts, the Rhizoma Anemarrhenae 25 parts, Rhizoma Phragmitis 18 parts, red Chen Ai 8 parts, hedgehog chrysanthemum 7 parts, Rhizoma Curcumae 7 parts, Herba Damnacanthi 15 parts, Ipomoea hungaiensis Lingelsh. Et Borza. 21 parts, 12 parts, Poria, Semen Benincasae 22 parts, Radix Asteris 8 parts, Bombyx Batryticatus 9 parts, Herba Violae dissectae 10 parts, Herba Sonchi Arvensis 7 parts, Herba Sarcandrae 6 parts, Radix Rumicis Patientiae 10 parts, Caulis Piperis Kadsurae 6 parts, Radix Notoginseng 19 parts, Sargassum 12 parts, Catechu 8 parts and 5 parts, Radix Glycyrrhizae.
The present invention also provides a kind of preparation method for the treatment of the Chinese medicine of child's phlegm-heat obstructing lung type lobar pneumonia, and when form of Chinese drug is spray, its preparation method comprises the following steps:
A, take all raw medicinal materials in described ratio, add relative to the mixture quality 3-5 obtained water soaking 3-10 hour doubly, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, decoct 3 times, merge decoction liquor to filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;
B, the medicinal residues of step a are added 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid, 80-160 order filters, get 6000-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;
C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.
The present invention also provides a kind of preparation method for the treatment of the Chinese medicine of child's phlegm-heat obstructing lung type lobar pneumonia, and when the dosage form of Chinese medicine is syrup, its preparation method comprises the following steps:
The first step, Radix Ophiopogonis, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, red Chen Ai and hedgehog chrysanthemum are mixed in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 80% ~ 90%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 2 hours ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder;
Second step, Rhizoma Curcumae, Herba Damnacanthi, Ipomoea hungaiensis Lingelsh. Et Borza., Poria, Semen Benincasae and Radix Asteris are mixed in described ratio, be ground into powder, be that the ethanol of 85% ~ 95% is as solvent with determining alcohol, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.25 ~ 1.27, dry with spray dryer, be ground into 100 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 3 ~ 5 times of second step mixture quality;
3rd step, remaining raw medicinal material is mixed in described ratio, add relative to mixture 4 ~ 6 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter respectively, each time filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;
4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 3 ~ 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 30 ~ 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.3% or paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05%.
The present invention also provides a kind of preparation method for the treatment of the Chinese medicine of child's phlegm-heat obstructing lung type lobar pneumonia, and when the dosage form of Chinese medicine is granule, its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
The beneficial effect that technical scheme provided by the invention is brought is: the present invention has heat clearing away eliminating stagnation, effect of removing toxic substances and promoting pus discharge, holds concurrently and detoxifies with pathogenic fire reducing, change turbid eliminating the phlegm, promoting blood circulation to remove blood stasis, the heap soil or fertilizer over and around the roots of solution expectorant, the stasis of blood, pyretic toxicity is stagnant, with suitable lung eliminating stagnation eliminating carbuncle, cure mainly phlegm-heat obstructing lung type lobar pneumonia; And processing technology is easy, the little and convenient drug administration of toxic and side effects, medicament is easy to manufacture, and new drug with low cost, focus of going directly, healing time is short, not easily recurs after healing.
Detailed description of the invention
Primary disease belongs to by Chinese medicine " breathing with cough ", " pulmonary distension ", the category such as " pathogenic wind-warm ".Think that primary disease is many in positive QI-insufficiency, when defending outer miopragia, caused by being invaded by exogenous pathogen.As Qing Dynasty's doctor's Ye Gui a, famous physician of the Qing Dynasty was once pointed out " warm pathogen tend to attack the upper orifices, attacking the lung first ".Namely the exopathogen such as pathogenic wind-warm invasion and attack human body, relates to lungs, produces a series of pathological change.Exopathogen both can be the heresy of wind heat, also can be the heresy of wind and cold, defends, make impaired depurative descending of lung QI and produce disease, also can pathogenic heat pent up in lung, or phlegm-damp staying in lung from the beginning of infringement lung.Primary disease is in evolution, and the friendship of generally just struggling against through heresy is striven, and often just can win heresy, and the card feelings of impairment of both QI and YIN can appear in the later stage.If vital QI cannot conquer pathogen, yang-energy can be formed for de-critical syndrome.
Therefore, treatment child phlegm-heat obstructing lung type lobar pneumonia, the present invention is with heat clearing away eliminating stagnation, removing toxic substances and promoting pus discharge is primary treatment principle, holds concurrently with pathogenic fire reducing removing toxic substances, changes turbid eliminating the phlegm, promoting blood circulation to remove blood stasis, the heap soil or fertilizer over and around the roots of solution expectorant, the stasis of blood, pyretic toxicity is stagnant, with suitable lung eliminating stagnation eliminating carbuncle, selects prescription: Radix Ophiopogonis, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, red Chen Ai, hedgehog chrysanthemum, Rhizoma Curcumae, Herba Damnacanthi, Ipomoea hungaiensis Lingelsh. Et Borza., Poria, Semen Benincasae, Radix Asteris, Bombyx Batryticatus, Herba Violae dissectae, Herba Sonchi Arvensis, Herba Sarcandrae, Radix Rumicis Patientiae, Caulis Piperis Kadsurae, Radix Notoginseng, Sargassum, Catechu and Radix Glycyrrhizae.
Radix Ophiopogonis in its side, the Rhizoma Anemarrhenae, Rhizoma Phragmitis heat extraction are tired clearly, red Chen Ai, hedgehog chrysanthemum, Rhizoma Curcumae blood stasis removing and clots absorbing; Herba Damnacanthi, Ipomoea hungaiensis Lingelsh. Et Borza. (white), Poria dampness removing, Semen Benincasae, Bombyx Batryticatus dissipating phlegm and resolving masses; Radix Asteris, Herba Sonchi Arvensis stopping coughing and removing phlegm; Herba Violae dissectae, Herba Sonchi Arvensis, Herba Sarcandrae, Radix Rumicis Patientiae heat-clearing and toxic substances removing; Caulis Piperis Kadsurae, Radix Notoginseng, Sargassum, Catechu anti-endotoxin improve immunologic function; , Radix Glycyrrhizae heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:
Radix Ophiopogonis: sweet; Micro-hardship; Cold.Return lung; Stomach; Heart channel.Nourishing YIN and moistening the lung; Reinforcing stomach reg fluid; Clear away heart-fire relieving restlessness.Main dryness of the lung dry cough; Lung abscess; Deficiency of YIN chronic cough; Tianjin wound is thirsty; Quench one's thirst; Vexed insomnia; Have sore throat; Dryness of the intestine constipation; Heat in blood tells nosebleed.
The Rhizoma Anemarrhenae: bitter, sweet, cold.Return lung, stomach, kidney channel.Clearing away heat-fire, promotes the production of body fluid and moisturizes.For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.
Rhizoma Phragmitis: sweet, cold, nontoxic.Be included into the heart, lung.Control lung abscess dysphoria with smothery sensation.Lung-heat clearing and detoxification; Cough-relieving evacuation of pus.Main lung abscess vomiting pus; Cough due to lung-heat; Carbuncle
Red Chen Ai: bitter, pungent, temperature.Blood stasis removing and clots absorbing, therapeutic method to keep the adverse QI flowing downwards dredging collateral.Stop long-pending lower abdominal distention pain for congestion in puerperal, traumatic injury, congestion swells and ache, due to wound defecation hematochezia.
Hedgehog chrysanthemum: sweet is cool.Blood stasis removing and clots absorbing, removing heat from blood, hemostasis, heat-clearing and toxic substances removing; Cooling blood for hemostasis.Main sore and toxic; Scrofula; Spit blood; Epistaxis; Anovulatory dysfunctional uterine hemorrhage; Traumatic hemorrhage; Cure mainly wound, hemorrhage, spit blood, epistaxis, anovulatory dysfunctional uterine hemorrhage; Sore carbuncle is controlled in external.
Rhizoma Curcumae: pungent, bitter, temperature.Return liver, spleen channel.Circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For Dan abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.
Herba Damnacanthi: sweet, bitter is flat.Expelling wind and removing dampness, promoting blood circulation and stopping pain.For hepatitis, bones and muscles pain due to rheumatism, traumatic injury, caries pain.
Ipomoea hungaiensis Lingelsh. Et Borza. (white): sweet light; Flat.Return liver; Spleen; Lung meridian.Heat clearing away; Dehumidifying; Cough-relieving; Spleen invigorating.Main jaundice; Chronic hepatitis; Cough due to lung-heat; Hematochezia; Breast is few; Leukorrhagia; Infantile malnutrition; Burn due to hot liquid or fire. control lung-heat, quench one's thirst, diuresis; Control lung abscess cough, promoting lactation.
Poria: sweet, light is flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Semen Benincasae: sweet, cold.Lung heat clearing, reduce phlegm, evacuation of pus.Be applicable to the diseases such as cough due to lung-heat, lung abscess, acute appendicitis.
Radix Asteris: pungent, bitter, temperature.Return lung meridian.Nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm.Breath with cough for abundant expectoration, new chronic cough is coughed, chronic cough hemoptysis.
Bombyx Batryticatus: acrid in the mouth; Salty; Property is put down.Return liver; Lung; Stomach warp.Expelling wind and relieving convulsion; Dissipating phlegm and resolving masses; Resolving toxin and disinhibiting the throat.Main frightened epilepsy is twitched; stroke facial hemiparalysis; Migraine and general headache; Abscess of throat; Scrofula; Mumps; Rubella; Sore.
Herba Violae dissectae: bitter in the mouth; Cold in nature.GUIXIN; Gallbladder; Spleen; Liver Channel.Heat-clearing and toxic substances removing; Inducing diuresis and reducing edema.Main furuncle swelling toxin; Measles pyretic toxicity; Pneumonia; Pleuritis; Stranguria with turbid discharge; Leucorrhea; Nephritis.Heat-clearing and toxic substances removing, subduing inflammation.Control innominate toxic swelling, furuncle.
Herba Sonchi Arvensis: bitter, antiperspirant.Heat-clearing and toxic substances removing, tonify deficiency cough-relieving.Control bacillary dysentery, laryngitis, weak cough, internal hemorrhoid is deviate from, leucorrhea.
Herba Sarcandrae: bitter, pungent, flat.GUIXIN, Liver Channel.Clearing away heat and cooling blood, speckle removing of invigorating blood circulation, dispelling wind and removing obstruction in the collateral.For heat in blood purpura, purpura, rheumatic arthralgia, traumatic injury; Another name, synthetism lotus.
Radix Rumicis Patientiae: bitter; Acid; Cold in nature.Heat-clearing and toxic substances removing; Hemostasia and detumescence; Relieving constipation; Parasite killing.Main haematemesis; Epistaxis; Have blood in stool; Metrorrhagia; Leucorrhea with red and white discharge; Purpura; Dysentery; Hepatitis; Constipation; Dysuria; Carbuncle pyogenic infections from tumour or sore; Scabies; Traumatic injury; Burn and scald.Promoting blood circulation to remove blood stasis, hemostasis, heat-clearing and toxic substances removing, loosening bowel to relieve constipation.
Caulis Piperis Kadsurae: pungent, bitter, tepor.Enter the heart, kidney two warp.Wind-damp dispelling, the meridian dredging, regulates the flow of vital energy.Control anemofrigid-damp arthralgia, arthralgia, the contracture of muscle arteries and veins, traumatic injury, asthma, chronic cough.
Radix Notoginseng: sweet, micro-hardship, temperature.Return liver, stomach warp.Dissipating blood stasis stops blooding, subduing swelling and relieving pain.For spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, and breast abdomen twinges, tumbling and swelling.
Sargassum: bitter, salty, cold.Return liver, stomach, kidney channel.Hard masses softening and resolving, expectorant, diuretic.For goiter, scrofula, painful and swollen testis, phlegm retention edema.
Catechu: heat clearing away, reduces phlegm, and hemostasis, helps digestion, granulation promoting, analgesic therapy.Control phlegm-heat cough, quench one's thirst, spit blood, epistaxis, hematuria, dysentery, metrorrhagia, infantile dyspepsia, ulcerative gingivitis, aphtha, sore throat, eczema.
Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 spray of the present invention
Get Radix Ophiopogonis 25g, Rhizoma Anemarrhenae 27g, Rhizoma Phragmitis 16g, red Chen Ai 6g, hedgehog chrysanthemum 9g, Rhizoma Curcumae 8g, Herba Damnacanthi 21g, Ipomoea hungaiensis Lingelsh. Et Borza. 16g, Poria 10g, Semen Benincasae 20g, Radix Asteris 12g, Bombyx Batryticatus 7g, Herba Violae dissectae 12g, Herba Sonchi Arvensis 6g, Herba Sarcandrae 9g, Radix Rumicis Patientiae 7g, Caulis Piperis Kadsurae 8g, Radix Notoginseng 16g, Sargassum 15g, Catechu 6g and Radix Glycyrrhizae 8g.
Its preparation method comprises the following steps:
A, take all raw medicinal materials in described ratio, add the water soaking 10 hours relative to the mixture quality 3 times obtained, after intense fire boils, using slow fire instead, to decoct the 30 minutes dosage to medicinal liquid be slowly 300ml, decocts 3 times, merges decoction liquor and filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;
B, the medicinal residues of step a are added 60% soak with ethanol 1.5 hours, extract twice, each 1 hour, merge extractive liquid, 160 orders filter, 10000 revs/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;
C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.
Embodiment 2 syrup of the present invention
Get Radix Ophiopogonis 30g, Rhizoma Anemarrhenae 30g, Rhizoma Phragmitis 20g, red Chen Ai 7g, hedgehog chrysanthemum 8g, Rhizoma Curcumae 9g, Herba Damnacanthi 23g, Ipomoea hungaiensis Lingelsh. Et Borza. 15g, Poria 8g, Semen Benincasae 25g, Radix Asteris 9g, Bombyx Batryticatus 8g, Herba Violae dissectae 15g, Herba Sonchi Arvensis 11g, Herba Sarcandrae 7g, Radix Rumicis Patientiae 8g, Caulis Piperis Kadsurae 7g, Radix Notoginseng 17g, Sargassum 11g, Catechu 7g and Radix Glycyrrhizae 6g.
Its preparation method comprises the following steps:
The first step, Radix Ophiopogonis, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, red Chen Ai and hedgehog chrysanthemum are mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 90%, heating and refluxing extraction 3 times, each reflux, extract, 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 200 orders subsequently, obtain dry powder;
Second step, Rhizoma Curcumae, Herba Damnacanthi, Ipomoea hungaiensis Lingelsh. Et Borza., Poria, Semen Benincasae and Radix Asteris being mixed in described ratio, be ground into powder, is that the ethanol of 95% is as solvent with determining alcohol, flood 72 hours, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.27, dry with spray dryer, be ground into 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 4 times of second step mixture quality;
3rd step, remaining raw medicinal material is mixed in described ratio, add relative to mixture 5 times amount determining alcohol be 80% alcohol reflux 3 times, each 3 hours, filter respectively, each time filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.22, in 65 DEG C of reduced vacuum dryings, obtains dry powder;
4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 4 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.3% or paraben preservative are as ethyl hydroxybenzoate 0.05%.
Embodiment 3 granule of the present invention
Get Radix Ophiopogonis 28g, Rhizoma Anemarrhenae 25g, Rhizoma Phragmitis 18g, red Chen Ai 8g, hedgehog chrysanthemum 7g, Rhizoma Curcumae 7g, Herba Damnacanthi 15g, Ipomoea hungaiensis Lingelsh. Et Borza. 21g, Poria 12g, Semen Benincasae 22g, Radix Asteris 8g, Bombyx Batryticatus 9g, Herba Violae dissectae 10g, Herba Sonchi Arvensis 7g, Herba Sarcandrae 6g, Radix Rumicis Patientiae 10g, Caulis Piperis Kadsurae 6g, Radix Notoginseng 19g, Sargassum 12g, Catechu 8g and Radix Glycyrrhizae 5g.
Its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 95%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 DEG C subsequently under vacuum 0.07Mpa, relative density is the mastic of 1.06, spraying dry, the inlet temperature 175 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.1 times in the dried cream powder obtained, makes granule, in 50 DEG C of dryings, obtains granule.
Described Chinese medicine is decocted decoction in use and is taken, and every day 1 dose, decocting takes at twice, within 10 days, is a course for the treatment of; When this Chinese medicine composition be pill, capsule or containing tablet, tablet, granule use time, three times 10 days on the one is a course for the treatment of; When this Chinese medicine composition is syrup use, three times on the one 10 days is a course for the treatment of; When this Chinese medicine composition is spray use, 3-5 time on the one 10 days is a course for the treatment of.
Toxicity test:
Acute toxicity test: application NIH mice 60, SPF level, male and female half and half, body weight 17 ~ 24g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; Syrup prepared by embodiments of the invention 2 is mixed with water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage syrup LD50>28.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage Chinese medicine of the present invention is 745 times of quantity.Therefore the syrup acute toxicity of the embodiment of the present invention 2 is low, clinical drug safety.
Long term toxicity test: the spray of the embodiment of the present invention 1 is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Long term toxicity test: the granule of the embodiment of the present invention 3 is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection:
Select my institute phlegm-heat obstructing lung type lobar pneumonia infant 162 in July 2013 October in 2011 example, man 82 example, female 80 example, 11 months-12 years old age, 6.5 years old mean age.All patients are all after I institute chest X line, routine blood test, Sputum smears and mycoplasma pneumoniae antibody etc. check, meet the diagnostic criteria of child's lobar pneumonia, be diagnosed as lobar pneumonia, Chinese medical discrimination is phlegm-heat obstructing lung type, clinical manifestation is heating, dyspnea, cough, conducting lung X-ray examination is the lobe of the lung or segmental changes, in large lamellar increase in density shadow or pulmonary parenchyma wellability pathological changes etc.; .Infant carries out routine blood test detection, wherein peripheral hemogram WBC (5-10) * 10
9/ L 78 example, W BC< 4.0*10
9/ L 5 example, WBC > 10*10
9/ L 79 example; Neutrophilic granulocyte ratio > 80% 49 example, mononuclear cell ratio > 8% 67 example.Be divided into four groups at random, four groups of no significant difference (P > 0.05), have comparability.
Aerosol therapy group: 40 people, male 20 people, female 20 people.
Syrup treatment group: 40 people, male 20 people, female 20 people.
Granules in Treating group: 41 people, male 21 people, female 20 people.
Western medicine group: 41 people, male 21 people, female 20 people.
Diagnostic criteria:
1, clinical manifestation goes out cough, heating and tachypnea;
2, physical examination result shows its pulmonary's respiratory murmur and occurs the thick phenomenon of increasing, auscultation of lung audible and moist rales, and local respiratory murmur presents reducing tendency, shows voiced sound or flatness to after lesions position percussion;
3, chest X ray examination is carried out to it, inside the result display lobe of the lung, show homogeneous consolidation image.
Phlegm-heat obstructing lung type: high hot excessive thirst, cough, chest pain, coughs up yellow sputum or band blood, red tongue with yellow fur or greasy, slippery and rapid pulse or large.
Allly meet above-mentioned clinical criteria and be diagnosed as lobar pneumonia, Chinese medical discrimination meets phlegm-heat obstructing lung type.
Therapeutic Method:
Aerosol therapy group: use spray prepared by the embodiment of the present invention 1, every day 3 times, spray 5s, 10 days be 1 course for the treatment of at every turn.
Syrup treatment group: take syrup prepared by the embodiment of the present invention 2, every day 3 times, each 10ml 10 days is 1 course for the treatment of.
Granules in Treating group: take granule prepared by the embodiment of the present invention 3, every day 3 times, each half bag 10 days is 1 course for the treatment of.
Western medicine group: penicillin 400,000 unit, intramuscular injection, 2 times on the 1st or 6,000,000 units, quiet; Streptomycin 0.25g intramuscular injection, 2 times on the 1st; It within 10 days, is 1 course for the treatment of.
Efficacy assessment standard:
Formulate with reference to " Chinese medical disease Standardization of diagnosis and curative effect ".
Clinical cure: transference cure, body temperature is normal, and pulmonary's rale disappears, and x-ray check pulmonary lesions absorbs, and hemogram recovers normal.
Take a turn for the better: symptom alleviates, pulmonary's rale reduces, and x-ray check pulmonary lesions does not absorb completely.
Invalid: symptom and sign are all without improvement, or deterioration person.
Therapeutic outcome:
See table 1 and table 2, as can be seen from Table 1, adopt treatment by Chinese herbs child phlegm-heat obstructing lung type lobar pneumonia of the present invention, relative to Western medicine on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt treatment by Chinese herbs child phlegm-heat obstructing lung type lobar pneumonia of the present invention, relative to Western medicine, treatment the course for the treatment of on significantly shorten.
After table 1 Four composition does not treat 2 courses for the treatment of, Clinical efficacy comparison is routine
| Group | Number of cases | Clinical cure | Take a turn for the better | Invalid | Total effective rate |
| Aerosol therapy group | 40 | 32 | 8 | 0 | 100% |
| Syrup treatment group | 40 | 28 | 11 | 1 | 97.5% |
| Granules in Treating group | 41 | 30 | 11 | 0 | 100% |
| Western medicine group | 41 | 25 | 13 | 3 | 92.7% |
Table 2 Four composition does not treat number and the time comparative example (%) of clinical cure and improvement after 2 courses for the treatment of
According to the clinical statistics in above table, Chinese medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect.
Model case:
Grandson patient, female, 10 years old, in December, 2012 was gone to a doctor.Suddenly shiver without obvious inducement, high heat, body temperature 39.5 DEG C, scorching hot in the heart, chest pain, cough with blood-flecked phlegm, red tongue with yellow fur, slippery and rapid pulse.Other hospitalizes 3 days, symptom did not alleviate, exacerbation of symptoms, and spy carrys out my out-patient treatment.Health check-up: body temperature 365 DEG C, blood pressure 10/7kPa.Sheet shows: right upper lung lamellar increase in density shadow.Lab testing BC17.0*10
9/ L.Be diagnosed as right lobar pneumonia, Chinese medical discrimination: phlegm-heat obstructing lung type.Use the spray of Chinese medicine preparation embodiment 1 of the present invention, every day 3 times, spray 5s at every turn, after 5 days, cough symptom obviously alleviates, and within 12 days, substantially disappears afterwards.But still have cough after activity, amount of expectoration obviously reduces, continue use one week afterwards clinical cure leave hospital, following up a case by regular visits to a year and a half does not recur.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (7)
1. treat the Chinese medicine of child's phlegm-heat obstructing lung type lobar pneumonia for one kind, it is characterized in that, comprise following raw medicinal material: Radix Ophiopogonis, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, red Chen Ai, hedgehog chrysanthemum, Rhizoma Curcumae, Herba Damnacanthi, Ipomoea hungaiensis Lingelsh. Et Borza., Poria, Semen Benincasae, Radix Asteris, Bombyx Batryticatus, Herba Violae dissectae, Herba Sonchi Arvensis, Herba Sarcandrae, Radix Rumicis Patientiae, Caulis Piperis Kadsurae, Radix Notoginseng, Sargassum, Catechu and Radix Glycyrrhizae.
2. Chinese medicine according to claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Ophiopogonis 20-30 part, Rhizoma Anemarrhenae 20-30 part, Rhizoma Phragmitis 15-20 part, red Chen Ai 6-9 part, hedgehog chrysanthemum 6-9 part, Rhizoma Curcumae 6-9 part, Herba Damnacanthi 15-25 part, Ipomoea hungaiensis Lingelsh. Et Borza. 15-25 part, Poria 6-12 part, Semen Benincasae 15-30 part, Radix Asteris 6-12 part, Bombyx Batryticatus 6-9 part, Herba Violae dissectae 10-15 part, Herba Sonchi Arvensis 6-12 part, Herba Sarcandrae 6-10 part, Radix Rumicis Patientiae 7-12 part, Caulis Piperis Kadsurae 6-9 part, Radix Notoginseng 15-19 part, Sargassum 10-15 part, Catechu 6-9 part and Radix Glycyrrhizae 5-10 part.
3. Chinese medicine according to claim 1 and 2, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Ophiopogonis 25-30 part, Rhizoma Anemarrhenae 25-30 part, Rhizoma Phragmitis 16-20 part, red Chen Ai 6-8 part, hedgehog chrysanthemum 7-9 part, Rhizoma Curcumae 7-9 part, Herba Damnacanthi 15-23 part, Ipomoea hungaiensis Lingelsh. Et Borza. 15-20 part, Poria 8-12 part, Semen Benincasae 20-25 part, Radix Asteris 8-12 part, Bombyx Batryticatus 7-9 part, Herba Violae dissectae 10-15 part, Herba Sonchi Arvensis 6-11 part, Herba Sarcandrae 6-9 part, Radix Rumicis Patientiae 7-10 part, Caulis Piperis Kadsurae 6-8 part, Radix Notoginseng 16-19 part, Sargassum 11-15 part, Catechu 6-8 part and Radix Glycyrrhizae 5-8 part.
4. according to the arbitrary described Chinese medicine of claim 1-3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Ophiopogonis 25 parts, the Rhizoma Anemarrhenae 27 parts, Rhizoma Phragmitis 16 parts, red Chen Ai 6 parts, hedgehog chrysanthemum 9 parts, Rhizoma Curcumae 8 parts, Herba Damnacanthi 21 parts, Ipomoea hungaiensis Lingelsh. Et Borza. 16 parts, 10 parts, Poria, Semen Benincasae 20 parts, Radix Asteris 12 parts, Bombyx Batryticatus 7 parts, Herba Violae dissectae 12 parts, Herba Sonchi Arvensis 6 parts, Herba Sarcandrae 9 parts, Radix Rumicis Patientiae 7 parts, Caulis Piperis Kadsurae 8 parts, Radix Notoginseng 16 parts, Sargassum 15 parts, Catechu 6 parts and 8 parts, Radix Glycyrrhizae.
5. according to the arbitrary described Chinese medicine of claim 1-3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Ophiopogonis 30 parts, the Rhizoma Anemarrhenae 30 parts, Rhizoma Phragmitis 20 parts, red Chen Ai 7 parts, hedgehog chrysanthemum 8 parts, Rhizoma Curcumae 9 parts, Herba Damnacanthi 23 parts, Ipomoea hungaiensis Lingelsh. Et Borza. 15 parts, 8 parts, Poria, Semen Benincasae 25 parts, Radix Asteris 9 parts, Bombyx Batryticatus 8 parts, Herba Violae dissectae 15 parts, Herba Sonchi Arvensis 11 parts, Herba Sarcandrae 7 parts, Radix Rumicis Patientiae 8 parts, Caulis Piperis Kadsurae 7 parts, Radix Notoginseng 17 parts, Sargassum 11 parts, Catechu 7 parts and 6 parts, Radix Glycyrrhizae.
6. according to the arbitrary described Chinese medicine of claim 1-3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Ophiopogonis 28 parts, the Rhizoma Anemarrhenae 25 parts, Rhizoma Phragmitis 18 parts, red Chen Ai 8 parts, hedgehog chrysanthemum 7 parts, Rhizoma Curcumae 7 parts, Herba Damnacanthi 15 parts, Ipomoea hungaiensis Lingelsh. Et Borza. 21 parts, 12 parts, Poria, Semen Benincasae 22 parts, Radix Asteris 8 parts, Bombyx Batryticatus 9 parts, Herba Violae dissectae 10 parts, Herba Sonchi Arvensis 7 parts, Herba Sarcandrae 6 parts, Radix Rumicis Patientiae 10 parts, Caulis Piperis Kadsurae 6 parts, Radix Notoginseng 19 parts, Sargassum 12 parts, Catechu 8 parts and 5 parts, Radix Glycyrrhizae.
7., according to the arbitrary described Chinese medicine of claim 1-6, it is characterized in that, when the dosage form of described Chinese medicine is spray, its preparation method comprises the following steps:
A, take all raw medicinal materials in described ratio, add relative to the mixture quality 3-5 obtained water soaking 3-10 hour doubly, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, decoct 3 times, merge decoction liquor to filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;
B, the medicinal residues of step a are added 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid, 80-160 order filters, get 6000-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;
C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410613643.3A CN104367942A (en) | 2014-11-05 | 2014-11-05 | Traditional Chinese medicine for treating lobar pneumonia with syndrome of phlegm-heat obstructing lung in children and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410613643.3A CN104367942A (en) | 2014-11-05 | 2014-11-05 | Traditional Chinese medicine for treating lobar pneumonia with syndrome of phlegm-heat obstructing lung in children and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104367942A true CN104367942A (en) | 2015-02-25 |
Family
ID=52547302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410613643.3A Pending CN104367942A (en) | 2014-11-05 | 2014-11-05 | Traditional Chinese medicine for treating lobar pneumonia with syndrome of phlegm-heat obstructing lung in children and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104367942A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105396071A (en) * | 2015-12-12 | 2016-03-16 | 王光辉 | Traditional Chinese medicine formula for treating children pneumonia |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050100616A1 (en) * | 2002-04-22 | 2005-05-12 | Matsuura Yakugyo Co., Ltd. | Preventive or therapeutic agent for pollen allergy, allergic rhinitis, atopic dermatitis, asthma or urticaria, or health food for prevention or improvement or reduction of symptoms thereof |
| CN1927340A (en) * | 2006-08-09 | 2007-03-14 | 宫庆国 | Medicine for treating infantile pneumonia |
| CN101019990A (en) * | 2007-03-19 | 2007-08-22 | 殷彬 | Chinese medicine for treating lobar pneumonia |
| CN102120010A (en) * | 2011-02-21 | 2011-07-13 | 田荣春 | Medicament for treating children pneumonia |
-
2014
- 2014-11-05 CN CN201410613643.3A patent/CN104367942A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050100616A1 (en) * | 2002-04-22 | 2005-05-12 | Matsuura Yakugyo Co., Ltd. | Preventive or therapeutic agent for pollen allergy, allergic rhinitis, atopic dermatitis, asthma or urticaria, or health food for prevention or improvement or reduction of symptoms thereof |
| CN1927340A (en) * | 2006-08-09 | 2007-03-14 | 宫庆国 | Medicine for treating infantile pneumonia |
| CN101019990A (en) * | 2007-03-19 | 2007-08-22 | 殷彬 | Chinese medicine for treating lobar pneumonia |
| CN102120010A (en) * | 2011-02-21 | 2011-07-13 | 田荣春 | Medicament for treating children pneumonia |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105396071A (en) * | 2015-12-12 | 2016-03-16 | 王光辉 | Traditional Chinese medicine formula for treating children pneumonia |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104127531B (en) | Traditional Chinese medicine composition for treating enterogastritis and preparation method thereof | |
| CN104398938A (en) | Traditional Chinese medicine for treating wind-heat invading lung lobar pneumonia and preparation method | |
| CN105412818A (en) | Medicine for treating tumors and preparation method thereof | |
| CN104623376B (en) | Be used for the treatment of prosopalgic medicine | |
| CN104623356B (en) | The Chinese medicine for the treatment of helicobacter pylori infections peptic ulcer | |
| CN103191331B (en) | Traditional Chinese medicine composition for treating bronchial asthma in remission stage | |
| CN103520506A (en) | Traditional Chinese medicine composition for treating breast cancer | |
| CN104367942A (en) | Traditional Chinese medicine for treating lobar pneumonia with syndrome of phlegm-heat obstructing lung in children and preparation method | |
| CN106620519A (en) | Drug for treating mammitis and preparation method thereof | |
| CN103386101B (en) | Traditional Chinese medicine preparation for nonspecific cystitis treatment and preparation method thereof | |
| CN106237155A (en) | A kind of decoction medicine treating exogenous high fever and preparation method thereof | |
| CN105327182A (en) | Medicine for treating child pertussis and preparation method thereof | |
| CN105497724A (en) | Traditional Chinese medicine preparation for treating cholelithiasis and preparation method thereof | |
| CN104998158A (en) | Pharmaceutical composition for treating liver cirrhosis and application thereof | |
| CN104771513A (en) | Traditional Chinese medicine composition for treating cholecystitis | |
| CN103386104B (en) | Traditional Chinese medicine composite for curing erysipelas and preparation method thereof | |
| CN107007697A (en) | One kind treats pelvic infecton or prostatitic Chinese medicine composition and its preparation | |
| CN105963586A (en) | Medicine for treating lung abscess and preparation method thereof | |
| CN105412679A (en) | Traditional Chinese medicine preparation for treating lung abscess and preparation method thereof | |
| CN104958672A (en) | Pharmaceutical composition for treating helicobacter pylori infectious gastropathy and preparation method of pharmaceutical composition | |
| CN105213975A (en) | A kind of pharmaceutical composition and application thereof for the treatment of liver cirrhosis | |
| CN104623222A (en) | Traditional Chinese medicine composition with effects of clearing away heat and toxic materials for treating breast cancer and preparation method thereof | |
| CN105168774A (en) | Traditional Chinese medicine preparation for treating scapulohumeral periarthritis and preparation method thereof | |
| CN104826068A (en) | Medicine for expelling wind and eliminating dampness and preparation method of medicine | |
| CN104524529A (en) | Medicine for treating phlegm-heat lung blocking type streptococcus pneumoniae and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150225 |