CN104367942A - Traditional Chinese medicine for treating lobar pneumonia with syndrome of phlegm-heat obstructing lung in children and preparation method - Google Patents

Abstract

The invention discloses a traditional Chinese medicine for treating lobar pneumonia with the syndrome of phlegm-heat obstructing lung in children and a preparation method. The traditional Chinese medicine is prepared from the following medicinal raw materials: ophiopogon root, rhizoma anemarrhenae, phragmites stem, artemisia selengensis turcz, takaikatzuchia lomonossowii, curcuma zedoary, indian damnacanthus herb, hungaian morning glory root, poria cocos, semen benincasae, radix asteris, silkworm larva, partedleaf violet herb, field sowthistle herb, sarcandra glabra, patience dock root, caulis pipers futokadsurae, pseudo-ginseng, seaweed, catechu and licorice root. The traditional Chinese medicine has the beneficial effects of clearing heat, eliminating stagnation, resolving toxin, expelling pus, lowering internal fire, dissolving turbidity, removing phlegm, activating blood circulation to remove stasis, eliminating stagnations of phlegm, stasis and heat-toxin, improving lung, eliminating stagnation and removing carbuncle, and is mainly used for treating lobar pneumonia with the syndrome of phlegm-heat obstructing lung in children. The traditional Chinese medicine has a simple and convenient preparation process and small toxic and side effect, is convenient to take and easy to prepare, is low in cost, and is capable of directly reaching the focus with short cure time and preventing relapse after healing.

Description

A kind of Chinese medicine and preparation method for the treatment of child's phlegm-heat obstructing lung type lobar pneumonia

Technical field

The present invention relates to pharmaceutical technology, particularly a kind of Chinese medicine and preparation method for the treatment of child's phlegm-heat obstructing lung type lobar pneumonia.

 

Background technology

Pneumonia is Childhood especially infant commonly encountered diseases in period and frequently-occurring disease, occupies and threatens (pneumonia, suffers from diarrhoea, anemia, rickets) first of the healthy and large disease of life common four of Chinese children.Pneumonia accounts for the 28-34% of less than 5 years old death of child ratio in global range according to statistics.Often be close on 1.55 hundred million children (< year) to suffer from an inflammation of the lungs, wherein 1100-2000 ten thousand (7-13%) needs hospitalization, brings very big burden to medical industry.Lobar pneumonia is common community-acquired pneumonia in children, is the acute lung tissue inflammation that various pathogenic infection causes, and pathological changes distribution is confined to the lung tissue of more than a lung section more, can be great Ye, also can be segmental.Child's lobar pneumonia sickness rate rises gradually in recent years, along with the factors such as clinical laboratory's Examined effect raising, antibiotic extensive use and Resistant strain increase participate in, all there is many transformations in the aspect such as child's lobar pneumonia cause of disease, epidemic, Clinical symptom and sign, treatment, brings very large difficulty to clinician's diagnosis and treatment work.

Lobar pneumonia (lobarpneumonia) is mainly caused by streptococcus pneumoniae, and pathological changes involves an above lung tissue of lung section, the acute inflammation oozed out based on Diffuse fibrous element in alveolar.Pathological changes originates in local alveolar, and rapid spread to lung section or whole great Ye.Onset is hurried clinically, and Chang Yigao heat, aversion to cold start, and then occur chest pain, cough, cough rusty expectoration, dyspnea, and have pulmonary consolidation sign and leukocyte counts to increase.About one week of the course of disease, body temperature rapid drawdown, transference cure.This disease is multiple is born in male adults.The common inducement of disease is suffered from cold, tired or drench with rain.Belong to the category such as the traditional Chinese medical science " pathogenic wind-warm ", " lung abscess ".

The cause of disease

Various bacteria all can cause lobar pneumonia, but the overwhelming majority is streptococcus pneumoniae, wherein the strongest with III type pathogenicity.Streptococcus pneumoniae is gram-negative cocci, has pod membrane, and its pathogenicity is because the pod membrane of macromolecule polysaccharide body is to the invasion and attack effect of tissue.Minority is pneumobacillus, staphylococcus aureus, Hemolytic streptococcus, hemophilus influenza etc.Streptococcus pneumoniae is the normal parasitic flora of oral cavity and nasopharynx part, if when the resistance of the discharge of bacteria self-purification function of respiratory tract and body is normal, do not cause pneumonia.When body catch cold, overtired, drunk, flu, diabetes, immunologic hypofunction etc. make respiratory tract defense function weakened, antibacterial invades alveolar makes alveolar wall capillary permeability strengthen by allergy, serosity and cellulose ooze out, in rich protein-contg exudate, antibacterial breeds rapidly, and spread to contiguous lung tissue by interalveolar pores or alveolar bronchiole, involve a lung section or the whole lobe of the lung.The transudate spreading frenulum bacterium between great Ye is caused by the leaf bronchogenic spread.

Western medicine therapy

1, antibiotic therapy: penicillin, sulfonamides, erythromycin, clean ancient mycin, cephalexin number;

2, symptomatic treatment: (1) high hot person: aspirin, antondin; (2) chest pain is violent: oral codeine; (3) cough is coughed up phlegm: mixture of ammonium chloride; (4) water-electrolyte balance is kept.(5) respiratory failure of suffering a shock handles accordingly

Primary disease belongs to by Chinese medicine " breathing with cough ", " pulmonary distension ", the category such as " pathogenic wind-warm ".Think that primary disease is many in positive QI-insufficiency, when defending outer miopragia, caused by being invaded by exogenous pathogen.As Qing Dynasty's doctor's Ye Gui a, famous physician of the Qing Dynasty was once pointed out " warm pathogen tend to attack the upper orifices, attacking the lung first ".Namely the exopathogen such as pathogenic wind-warm invasion and attack human body, relates to lungs, produces a series of pathological change.Exopathogen both can be the heresy of wind heat, also can be the heresy of wind and cold, defends, make impaired depurative descending of lung QI and produce disease, also can pathogenic heat pent up in lung, or phlegm-damp staying in lung from the beginning of infringement lung.Primary disease is in evolution, and the friendship of generally just struggling against through heresy is striven, and often just can win heresy, and the card feelings of impairment of both QI and YIN can appear in the later stage.If vital QI cannot conquer pathogen, yang-energy can be formed for de-critical syndrome.

Chinese medical discrimination is divided into:

Syndrome of WEI system (heat defends type at lung), card is shown in: heating, and micro evil wind is trembled with fear, lossless or hypohidrosis, headache, and cough, xerostomia is yearningly micro-, tongue tip side of red white or yellow thin fur, floating and rapid pulse.

Syndrome in QI system (phlegm-heat obstructing lung type), card is shown in: high hot excessive thirst, cough, chest pain, coughs up yellow sputum or band blood, red tongue with yellow fur or greasy, slippery and rapid pulse or large.

The heart-nutriment card (battalion's Re Neisheng type or heat attacking the pericardium type), card is shown in: high hot dusk, very irritated, cough with asthma was out of breath, or delirium, coma, the stuttering cold of the limbs of tongue, deep red tongue, thready,rolling and rapid pulse.

But western medical treatment lobar pneumonia, the course for the treatment of is longer, and widely apply antibiotic for a long time, expectorant easily produces drug resistance, clinical efficacy is not satisfactory, and the easy recurrent exerbation of the state of an illness, has a strong impact on the quality of life etc. of patient.

But, Chinese medicine lobar pneumonia, possess unique advantage and feature: utilize Traditional Chinese medical theory, on the basis of Overall View, by regulating qi-blood circulating, enhancing human body immunity power, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, treat according to different disease Mutiple Targets, strengthen the respiratory function of respiratory muscle, promote expectoration cough-relieving, relieving asthma, keep respiratory passage unblocked, drug effect is gone directly focus, safe and effective, the course for the treatment of is shorter, and not easily produce drug resistance, cost price is lower, convenient drug administration, patient is easy to accept, cure rate can be significantly improved, reduce complication, reduce relapse rate, significantly improve the quality of life etc. of patient.

 

Summary of the invention

The technical problem to be solved in the present invention is to provide a kind of Chinese medicine and preparation method for the treatment of child's phlegm-heat obstructing lung type lobar pneumonia, the present invention has heat clearing away eliminating stagnation, effect of removing toxic substances and promoting pus discharge, hold concurrently and detoxify with pathogenic fire reducing, change turbid eliminating the phlegm, promoting blood circulation to remove blood stasis, the heap soil or fertilizer over and around the roots of solution expectorant, the stasis of blood, pyretic toxicity is stagnant, with suitable lung eliminating stagnation eliminating carbuncle, cure mainly phlegm-heat obstructing lung type lobar pneumonia; And processing technology is easy, the little and convenient drug administration of toxic and side effects, medicament is easy to manufacture, and new drug with low cost, focus of going directly, healing time is short, not easily recurs after healing.

In order to realize foregoing invention object, the invention provides a kind of Chinese medicine for the treatment of child's phlegm-heat obstructing lung type lobar pneumonia, wherein, following raw medicinal material is comprised: Radix Ophiopogonis, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, red Chen Ai, hedgehog chrysanthemum, Rhizoma Curcumae, Herba Damnacanthi, Ipomoea hungaiensis Lingelsh. Et Borza., Poria, Semen Benincasae, Radix Asteris, Bombyx Batryticatus, Herba Violae dissectae, Herba Sonchi Arvensis, Herba Sarcandrae, Radix Rumicis Patientiae, Caulis Piperis Kadsurae, Radix Notoginseng, Sargassum, Catechu and Radix Glycyrrhizae.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Ophiopogonis 20-30 part, Rhizoma Anemarrhenae 20-30 part, Rhizoma Phragmitis 15-20 part, red Chen Ai 6-9 part, hedgehog chrysanthemum 6-9 part, Rhizoma Curcumae 6-9 part, Herba Damnacanthi 15-25 part, Ipomoea hungaiensis Lingelsh. Et Borza. 15-25 part, Poria 6-12 part, Semen Benincasae 15-30 part, Radix Asteris 6-12 part, Bombyx Batryticatus 6-9 part, Herba Violae dissectae 10-15 part, Herba Sonchi Arvensis 6-12 part, Herba Sarcandrae 6-10 part, Radix Rumicis Patientiae 7-12 part, Caulis Piperis Kadsurae 6-9 part, Radix Notoginseng 15-19 part, Sargassum 10-15 part, Catechu 6-9 part and Radix Glycyrrhizae 5-10 part.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Ophiopogonis 25-30 part, Rhizoma Anemarrhenae 25-30 part, Rhizoma Phragmitis 16-20 part, red Chen Ai 6-8 part, hedgehog chrysanthemum 7-9 part, Rhizoma Curcumae 7-9 part, Herba Damnacanthi 15-23 part, Ipomoea hungaiensis Lingelsh. Et Borza. 15-20 part, Poria 8-12 part, Semen Benincasae 20-25 part, Radix Asteris 8-12 part, Bombyx Batryticatus 7-9 part, Herba Violae dissectae 10-15 part, Herba Sonchi Arvensis 6-11 part, Herba Sarcandrae 6-9 part, Radix Rumicis Patientiae 7-10 part, Caulis Piperis Kadsurae 6-8 part, Radix Notoginseng 16-19 part, Sargassum 11-15 part, Catechu 6-8 part and Radix Glycyrrhizae 5-8 part.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Ophiopogonis 25 parts, the Rhizoma Anemarrhenae 27 parts, Rhizoma Phragmitis 16 parts, red Chen Ai 6 parts, hedgehog chrysanthemum 9 parts, Rhizoma Curcumae 8 parts, Herba Damnacanthi 21 parts, Ipomoea hungaiensis Lingelsh. Et Borza. 16 parts, 10 parts, Poria, Semen Benincasae 20 parts, Radix Asteris 12 parts, Bombyx Batryticatus 7 parts, Herba Violae dissectae 12 parts, Herba Sonchi Arvensis 6 parts, Herba Sarcandrae 9 parts, Radix Rumicis Patientiae 7 parts, Caulis Piperis Kadsurae 8 parts, Radix Notoginseng 16 parts, Sargassum 15 parts, Catechu 6 parts and 8 parts, Radix Glycyrrhizae.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Ophiopogonis 30 parts, the Rhizoma Anemarrhenae 30 parts, Rhizoma Phragmitis 20 parts, red Chen Ai 7 parts, hedgehog chrysanthemum 8 parts, Rhizoma Curcumae 9 parts, Herba Damnacanthi 23 parts, Ipomoea hungaiensis Lingelsh. Et Borza. 15 parts, 8 parts, Poria, Semen Benincasae 25 parts, Radix Asteris 9 parts, Bombyx Batryticatus 8 parts, Herba Violae dissectae 15 parts, Herba Sonchi Arvensis 11 parts, Herba Sarcandrae 7 parts, Radix Rumicis Patientiae 8 parts, Caulis Piperis Kadsurae 7 parts, Radix Notoginseng 17 parts, Sargassum 11 parts, Catechu 7 parts and 6 parts, Radix Glycyrrhizae.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Ophiopogonis 28 parts, the Rhizoma Anemarrhenae 25 parts, Rhizoma Phragmitis 18 parts, red Chen Ai 8 parts, hedgehog chrysanthemum 7 parts, Rhizoma Curcumae 7 parts, Herba Damnacanthi 15 parts, Ipomoea hungaiensis Lingelsh. Et Borza. 21 parts, 12 parts, Poria, Semen Benincasae 22 parts, Radix Asteris 8 parts, Bombyx Batryticatus 9 parts, Herba Violae dissectae 10 parts, Herba Sonchi Arvensis 7 parts, Herba Sarcandrae 6 parts, Radix Rumicis Patientiae 10 parts, Caulis Piperis Kadsurae 6 parts, Radix Notoginseng 19 parts, Sargassum 12 parts, Catechu 8 parts and 5 parts, Radix Glycyrrhizae.

The present invention also provides a kind of preparation method for the treatment of the Chinese medicine of child's phlegm-heat obstructing lung type lobar pneumonia, and when form of Chinese drug is spray, its preparation method comprises the following steps:

A, take all raw medicinal materials in described ratio, add relative to the mixture quality 3-5 obtained water soaking 3-10 hour doubly, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, decoct 3 times, merge decoction liquor to filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;

B, the medicinal residues of step a are added 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid, 80-160 order filters, get 6000-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;

C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.

The present invention also provides a kind of preparation method for the treatment of the Chinese medicine of child's phlegm-heat obstructing lung type lobar pneumonia, and when the dosage form of Chinese medicine is syrup, its preparation method comprises the following steps:

The first step, Radix Ophiopogonis, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, red Chen Ai and hedgehog chrysanthemum are mixed in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 80% ~ 90%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 2 hours ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder;

Second step, Rhizoma Curcumae, Herba Damnacanthi, Ipomoea hungaiensis Lingelsh. Et Borza., Poria, Semen Benincasae and Radix Asteris are mixed in described ratio, be ground into powder, be that the ethanol of 85% ~ 95% is as solvent with determining alcohol, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.25 ~ 1.27, dry with spray dryer, be ground into 100 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 3 ~ 5 times of second step mixture quality;

3rd step, remaining raw medicinal material is mixed in described ratio, add relative to mixture 4 ~ 6 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter respectively, each time filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;

4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 3 ~ 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 30 ~ 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.3% or paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05%.

The present invention also provides a kind of preparation method for the treatment of the Chinese medicine of child's phlegm-heat obstructing lung type lobar pneumonia, and when the dosage form of Chinese medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

The beneficial effect that technical scheme provided by the invention is brought is: the present invention has heat clearing away eliminating stagnation, effect of removing toxic substances and promoting pus discharge, holds concurrently and detoxifies with pathogenic fire reducing, change turbid eliminating the phlegm, promoting blood circulation to remove blood stasis, the heap soil or fertilizer over and around the roots of solution expectorant, the stasis of blood, pyretic toxicity is stagnant, with suitable lung eliminating stagnation eliminating carbuncle, cure mainly phlegm-heat obstructing lung type lobar pneumonia; And processing technology is easy, the little and convenient drug administration of toxic and side effects, medicament is easy to manufacture, and new drug with low cost, focus of going directly, healing time is short, not easily recurs after healing.

 

Detailed description of the invention

Primary disease belongs to by Chinese medicine " breathing with cough ", " pulmonary distension ", the category such as " pathogenic wind-warm ".Think that primary disease is many in positive QI-insufficiency, when defending outer miopragia, caused by being invaded by exogenous pathogen.As Qing Dynasty's doctor's Ye Gui a, famous physician of the Qing Dynasty was once pointed out " warm pathogen tend to attack the upper orifices, attacking the lung first ".Namely the exopathogen such as pathogenic wind-warm invasion and attack human body, relates to lungs, produces a series of pathological change.Exopathogen both can be the heresy of wind heat, also can be the heresy of wind and cold, defends, make impaired depurative descending of lung QI and produce disease, also can pathogenic heat pent up in lung, or phlegm-damp staying in lung from the beginning of infringement lung.Primary disease is in evolution, and the friendship of generally just struggling against through heresy is striven, and often just can win heresy, and the card feelings of impairment of both QI and YIN can appear in the later stage.If vital QI cannot conquer pathogen, yang-energy can be formed for de-critical syndrome.

Therefore, treatment child phlegm-heat obstructing lung type lobar pneumonia, the present invention is with heat clearing away eliminating stagnation, removing toxic substances and promoting pus discharge is primary treatment principle, holds concurrently with pathogenic fire reducing removing toxic substances, changes turbid eliminating the phlegm, promoting blood circulation to remove blood stasis, the heap soil or fertilizer over and around the roots of solution expectorant, the stasis of blood, pyretic toxicity is stagnant, with suitable lung eliminating stagnation eliminating carbuncle, selects prescription: Radix Ophiopogonis, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, red Chen Ai, hedgehog chrysanthemum, Rhizoma Curcumae, Herba Damnacanthi, Ipomoea hungaiensis Lingelsh. Et Borza., Poria, Semen Benincasae, Radix Asteris, Bombyx Batryticatus, Herba Violae dissectae, Herba Sonchi Arvensis, Herba Sarcandrae, Radix Rumicis Patientiae, Caulis Piperis Kadsurae, Radix Notoginseng, Sargassum, Catechu and Radix Glycyrrhizae.

Radix Ophiopogonis in its side, the Rhizoma Anemarrhenae, Rhizoma Phragmitis heat extraction are tired clearly, red Chen Ai, hedgehog chrysanthemum, Rhizoma Curcumae blood stasis removing and clots absorbing; Herba Damnacanthi, Ipomoea hungaiensis Lingelsh. Et Borza. (white), Poria dampness removing, Semen Benincasae, Bombyx Batryticatus dissipating phlegm and resolving masses; Radix Asteris, Herba Sonchi Arvensis stopping coughing and removing phlegm; Herba Violae dissectae, Herba Sonchi Arvensis, Herba Sarcandrae, Radix Rumicis Patientiae heat-clearing and toxic substances removing; Caulis Piperis Kadsurae, Radix Notoginseng, Sargassum, Catechu anti-endotoxin improve immunologic function; , Radix Glycyrrhizae heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Radix Ophiopogonis: sweet; Micro-hardship; Cold.Return lung; Stomach; Heart channel.Nourishing YIN and moistening the lung; Reinforcing stomach reg fluid; Clear away heart-fire relieving restlessness.Main dryness of the lung dry cough; Lung abscess; Deficiency of YIN chronic cough; Tianjin wound is thirsty; Quench one's thirst; Vexed insomnia; Have sore throat; Dryness of the intestine constipation; Heat in blood tells nosebleed.

The Rhizoma Anemarrhenae: bitter, sweet, cold.Return lung, stomach, kidney channel.Clearing away heat-fire, promotes the production of body fluid and moisturizes.For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.

Rhizoma Phragmitis: sweet, cold, nontoxic.Be included into the heart, lung.Control lung abscess dysphoria with smothery sensation.Lung-heat clearing and detoxification; Cough-relieving evacuation of pus.Main lung abscess vomiting pus; Cough due to lung-heat; Carbuncle

Red Chen Ai: bitter, pungent, temperature.Blood stasis removing and clots absorbing, therapeutic method to keep the adverse QI flowing downwards dredging collateral.Stop long-pending lower abdominal distention pain for congestion in puerperal, traumatic injury, congestion swells and ache, due to wound defecation hematochezia.

Hedgehog chrysanthemum: sweet is cool.Blood stasis removing and clots absorbing, removing heat from blood, hemostasis, heat-clearing and toxic substances removing; Cooling blood for hemostasis.Main sore and toxic; Scrofula; Spit blood; Epistaxis; Anovulatory dysfunctional uterine hemorrhage; Traumatic hemorrhage; Cure mainly wound, hemorrhage, spit blood, epistaxis, anovulatory dysfunctional uterine hemorrhage; Sore carbuncle is controlled in external.

Rhizoma Curcumae: pungent, bitter, temperature.Return liver, spleen channel.Circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For Dan abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.

Herba Damnacanthi: sweet, bitter is flat.Expelling wind and removing dampness, promoting blood circulation and stopping pain.For hepatitis, bones and muscles pain due to rheumatism, traumatic injury, caries pain.

Ipomoea hungaiensis Lingelsh. Et Borza. (white): sweet light; Flat.Return liver; Spleen; Lung meridian.Heat clearing away; Dehumidifying; Cough-relieving; Spleen invigorating.Main jaundice; Chronic hepatitis; Cough due to lung-heat; Hematochezia; Breast is few; Leukorrhagia; Infantile malnutrition; Burn due to hot liquid or fire. control lung-heat, quench one's thirst, diuresis; Control lung abscess cough, promoting lactation.

Poria: sweet, light is flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.

Semen Benincasae: sweet, cold.Lung heat clearing, reduce phlegm, evacuation of pus.Be applicable to the diseases such as cough due to lung-heat, lung abscess, acute appendicitis.

Radix Asteris: pungent, bitter, temperature.Return lung meridian.Nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm.Breath with cough for abundant expectoration, new chronic cough is coughed, chronic cough hemoptysis.

Bombyx Batryticatus: acrid in the mouth; Salty; Property is put down.Return liver; Lung; Stomach warp.Expelling wind and relieving convulsion; Dissipating phlegm and resolving masses; Resolving toxin and disinhibiting the throat.Main frightened epilepsy is twitched; stroke facial hemiparalysis; Migraine and general headache; Abscess of throat; Scrofula; Mumps; Rubella; Sore.

Herba Violae dissectae: bitter in the mouth; Cold in nature.GUIXIN; Gallbladder; Spleen; Liver Channel.Heat-clearing and toxic substances removing; Inducing diuresis and reducing edema.Main furuncle swelling toxin; Measles pyretic toxicity; Pneumonia; Pleuritis; Stranguria with turbid discharge; Leucorrhea; Nephritis.Heat-clearing and toxic substances removing, subduing inflammation.Control innominate toxic swelling, furuncle.

Herba Sonchi Arvensis: bitter, antiperspirant.Heat-clearing and toxic substances removing, tonify deficiency cough-relieving.Control bacillary dysentery, laryngitis, weak cough, internal hemorrhoid is deviate from, leucorrhea.

Herba Sarcandrae: bitter, pungent, flat.GUIXIN, Liver Channel.Clearing away heat and cooling blood, speckle removing of invigorating blood circulation, dispelling wind and removing obstruction in the collateral.For heat in blood purpura, purpura, rheumatic arthralgia, traumatic injury; Another name, synthetism lotus.

Radix Rumicis Patientiae: bitter; Acid; Cold in nature.Heat-clearing and toxic substances removing; Hemostasia and detumescence; Relieving constipation; Parasite killing.Main haematemesis; Epistaxis; Have blood in stool; Metrorrhagia; Leucorrhea with red and white discharge; Purpura; Dysentery; Hepatitis; Constipation; Dysuria; Carbuncle pyogenic infections from tumour or sore; Scabies; Traumatic injury; Burn and scald.Promoting blood circulation to remove blood stasis, hemostasis, heat-clearing and toxic substances removing, loosening bowel to relieve constipation.

Caulis Piperis Kadsurae: pungent, bitter, tepor.Enter the heart, kidney two warp.Wind-damp dispelling, the meridian dredging, regulates the flow of vital energy.Control anemofrigid-damp arthralgia, arthralgia, the contracture of muscle arteries and veins, traumatic injury, asthma, chronic cough.

Radix Notoginseng: sweet, micro-hardship, temperature.Return liver, stomach warp.Dissipating blood stasis stops blooding, subduing swelling and relieving pain.For spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, and breast abdomen twinges, tumbling and swelling.

Sargassum: bitter, salty, cold.Return liver, stomach, kidney channel.Hard masses softening and resolving, expectorant, diuretic.For goiter, scrofula, painful and swollen testis, phlegm retention edema.

Catechu: heat clearing away, reduces phlegm, and hemostasis, helps digestion, granulation promoting, analgesic therapy.Control phlegm-heat cough, quench one's thirst, spit blood, epistaxis, hematuria, dysentery, metrorrhagia, infantile dyspepsia, ulcerative gingivitis, aphtha, sore throat, eczema.

Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

         

Embodiment 1 spray of the present invention

Get Radix Ophiopogonis 25g, Rhizoma Anemarrhenae 27g, Rhizoma Phragmitis 16g, red Chen Ai 6g, hedgehog chrysanthemum 9g, Rhizoma Curcumae 8g, Herba Damnacanthi 21g, Ipomoea hungaiensis Lingelsh. Et Borza. 16g, Poria 10g, Semen Benincasae 20g, Radix Asteris 12g, Bombyx Batryticatus 7g, Herba Violae dissectae 12g, Herba Sonchi Arvensis 6g, Herba Sarcandrae 9g, Radix Rumicis Patientiae 7g, Caulis Piperis Kadsurae 8g, Radix Notoginseng 16g, Sargassum 15g, Catechu 6g and Radix Glycyrrhizae 8g.

Its preparation method comprises the following steps:

A, take all raw medicinal materials in described ratio, add the water soaking 10 hours relative to the mixture quality 3 times obtained, after intense fire boils, using slow fire instead, to decoct the 30 minutes dosage to medicinal liquid be slowly 300ml, decocts 3 times, merges decoction liquor and filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;

B, the medicinal residues of step a are added 60% soak with ethanol 1.5 hours, extract twice, each 1 hour, merge extractive liquid, 160 orders filter, 10000 revs/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;

C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.

 

Embodiment 2 syrup of the present invention

Get Radix Ophiopogonis 30g, Rhizoma Anemarrhenae 30g, Rhizoma Phragmitis 20g, red Chen Ai 7g, hedgehog chrysanthemum 8g, Rhizoma Curcumae 9g, Herba Damnacanthi 23g, Ipomoea hungaiensis Lingelsh. Et Borza. 15g, Poria 8g, Semen Benincasae 25g, Radix Asteris 9g, Bombyx Batryticatus 8g, Herba Violae dissectae 15g, Herba Sonchi Arvensis 11g, Herba Sarcandrae 7g, Radix Rumicis Patientiae 8g, Caulis Piperis Kadsurae 7g, Radix Notoginseng 17g, Sargassum 11g, Catechu 7g and Radix Glycyrrhizae 6g.

Its preparation method comprises the following steps:

The first step, Radix Ophiopogonis, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, red Chen Ai and hedgehog chrysanthemum are mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 90%, heating and refluxing extraction 3 times, each reflux, extract, 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 200 orders subsequently, obtain dry powder;

Second step, Rhizoma Curcumae, Herba Damnacanthi, Ipomoea hungaiensis Lingelsh. Et Borza., Poria, Semen Benincasae and Radix Asteris being mixed in described ratio, be ground into powder, is that the ethanol of 95% is as solvent with determining alcohol, flood 72 hours, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.27, dry with spray dryer, be ground into 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 4 times of second step mixture quality;

3rd step, remaining raw medicinal material is mixed in described ratio, add relative to mixture 5 times amount determining alcohol be 80% alcohol reflux 3 times, each 3 hours, filter respectively, each time filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.22, in 65 DEG C of reduced vacuum dryings, obtains dry powder;

4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 4 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.3% or paraben preservative are as ethyl hydroxybenzoate 0.05%.

 

Embodiment 3 granule of the present invention

Get Radix Ophiopogonis 28g, Rhizoma Anemarrhenae 25g, Rhizoma Phragmitis 18g, red Chen Ai 8g, hedgehog chrysanthemum 7g, Rhizoma Curcumae 7g, Herba Damnacanthi 15g, Ipomoea hungaiensis Lingelsh. Et Borza. 21g, Poria 12g, Semen Benincasae 22g, Radix Asteris 8g, Bombyx Batryticatus 9g, Herba Violae dissectae 10g, Herba Sonchi Arvensis 7g, Herba Sarcandrae 6g, Radix Rumicis Patientiae 10g, Caulis Piperis Kadsurae 6g, Radix Notoginseng 19g, Sargassum 12g, Catechu 8g and Radix Glycyrrhizae 5g.

Its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 95%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 DEG C subsequently under vacuum 0.07Mpa, relative density is the mastic of 1.06, spraying dry, the inlet temperature 175 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.1 times in the dried cream powder obtained, makes granule, in 50 DEG C of dryings, obtains granule.

Described Chinese medicine is decocted decoction in use and is taken, and every day 1 dose, decocting takes at twice, within 10 days, is a course for the treatment of; When this Chinese medicine composition be pill, capsule or containing tablet, tablet, granule use time, three times 10 days on the one is a course for the treatment of; When this Chinese medicine composition is syrup use, three times on the one 10 days is a course for the treatment of; When this Chinese medicine composition is spray use, 3-5 time on the one 10 days is a course for the treatment of.

 

Toxicity test:

Acute toxicity test: application NIH mice 60, SPF level, male and female half and half, body weight 17 ~ 24g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; Syrup prepared by embodiments of the invention 2 is mixed with water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage syrup LD50>28.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage Chinese medicine of the present invention is 745 times of quantity.Therefore the syrup acute toxicity of the embodiment of the present invention 2 is low, clinical drug safety.

 

Long term toxicity test: the spray of the embodiment of the present invention 1 is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

 

Long term toxicity test: the granule of the embodiment of the present invention 3 is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

 

Clinical data:

Case selection:

Select my institute phlegm-heat obstructing lung type lobar pneumonia infant 162 in July 2013 October in 2011 example, man 82 example, female 80 example, 11 months-12 years old age, 6.5 years old mean age.All patients are all after I institute chest X line, routine blood test, Sputum smears and mycoplasma pneumoniae antibody etc. check, meet the diagnostic criteria of child's lobar pneumonia, be diagnosed as lobar pneumonia, Chinese medical discrimination is phlegm-heat obstructing lung type, clinical manifestation is heating, dyspnea, cough, conducting lung X-ray examination is the lobe of the lung or segmental changes, in large lamellar increase in density shadow or pulmonary parenchyma wellability pathological changes etc.; .Infant carries out routine blood test detection, wherein peripheral hemogram WBC (5-10) * 10 ⁹/ L 78 example, W BC< 4.0*10 ⁹/ L 5 example, WBC > 10*10 ⁹/ L 79 example; Neutrophilic granulocyte ratio > 80% 49 example, mononuclear cell ratio > 8% 67 example.Be divided into four groups at random, four groups of no significant difference (P > 0.05), have comparability.

Aerosol therapy group: 40 people, male 20 people, female 20 people.

Syrup treatment group: 40 people, male 20 people, female 20 people.

Granules in Treating group: 41 people, male 21 people, female 20 people.

Western medicine group: 41 people, male 21 people, female 20 people.

Diagnostic criteria:

1, clinical manifestation goes out cough, heating and tachypnea;

2, physical examination result shows its pulmonary's respiratory murmur and occurs the thick phenomenon of increasing, auscultation of lung audible and moist rales, and local respiratory murmur presents reducing tendency, shows voiced sound or flatness to after lesions position percussion;

3, chest X ray examination is carried out to it, inside the result display lobe of the lung, show homogeneous consolidation image.

 

Phlegm-heat obstructing lung type: high hot excessive thirst, cough, chest pain, coughs up yellow sputum or band blood, red tongue with yellow fur or greasy, slippery and rapid pulse or large.

Allly meet above-mentioned clinical criteria and be diagnosed as lobar pneumonia, Chinese medical discrimination meets phlegm-heat obstructing lung type.

 

Therapeutic Method:

Aerosol therapy group: use spray prepared by the embodiment of the present invention 1, every day 3 times, spray 5s, 10 days be 1 course for the treatment of at every turn.

Syrup treatment group: take syrup prepared by the embodiment of the present invention 2, every day 3 times, each 10ml 10 days is 1 course for the treatment of.

Granules in Treating group: take granule prepared by the embodiment of the present invention 3, every day 3 times, each half bag 10 days is 1 course for the treatment of.

Western medicine group: penicillin 400,000 unit, intramuscular injection, 2 times on the 1st or 6,000,000 units, quiet; Streptomycin 0.25g intramuscular injection, 2 times on the 1st; It within 10 days, is 1 course for the treatment of.

 

Efficacy assessment standard:

Formulate with reference to " Chinese medical disease Standardization of diagnosis and curative effect ".

Clinical cure: transference cure, body temperature is normal, and pulmonary's rale disappears, and x-ray check pulmonary lesions absorbs, and hemogram recovers normal.

Take a turn for the better: symptom alleviates, pulmonary's rale reduces, and x-ray check pulmonary lesions does not absorb completely.

Invalid: symptom and sign are all without improvement, or deterioration person.

Therapeutic outcome:

See table 1 and table 2, as can be seen from Table 1, adopt treatment by Chinese herbs child phlegm-heat obstructing lung type lobar pneumonia of the present invention, relative to Western medicine on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt treatment by Chinese herbs child phlegm-heat obstructing lung type lobar pneumonia of the present invention, relative to Western medicine, treatment the course for the treatment of on significantly shorten.

After table 1 Four composition does not treat 2 courses for the treatment of, Clinical efficacy comparison is routine

Group	Number of cases	Clinical cure	Take a turn for the better	Invalid	Total effective rate
						Aerosol therapy group	40	32	8	0	100%
Syrup treatment group	40	28	11	1	97.5%
						Granules in Treating group	41	30	11	0	100%
Western medicine group	41	25	13	3	92.7%

Table 2 Four composition does not treat number and the time comparative example (%) of clinical cure and improvement after 2 courses for the treatment of

According to the clinical statistics in above table, Chinese medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect.

 

Model case:

Grandson patient, female, 10 years old, in December, 2012 was gone to a doctor.Suddenly shiver without obvious inducement, high heat, body temperature 39.5 DEG C, scorching hot in the heart, chest pain, cough with blood-flecked phlegm, red tongue with yellow fur, slippery and rapid pulse.Other hospitalizes 3 days, symptom did not alleviate, exacerbation of symptoms, and spy carrys out my out-patient treatment.Health check-up: body temperature 365 DEG C, blood pressure 10/7kPa.Sheet shows: right upper lung lamellar increase in density shadow.Lab testing BC17.0*10 ⁹/ L.Be diagnosed as right lobar pneumonia, Chinese medical discrimination: phlegm-heat obstructing lung type.Use the spray of Chinese medicine preparation embodiment 1 of the present invention, every day 3 times, spray 5s at every turn, after 5 days, cough symptom obviously alleviates, and within 12 days, substantially disappears afterwards.But still have cough after activity, amount of expectoration obviously reduces, continue use one week afterwards clinical cure leave hospital, following up a case by regular visits to a year and a half does not recur.

                                     

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (7)

1. treat the Chinese medicine of child's phlegm-heat obstructing lung type lobar pneumonia for one kind, it is characterized in that, comprise following raw medicinal material: Radix Ophiopogonis, the Rhizoma Anemarrhenae, Rhizoma Phragmitis, red Chen Ai, hedgehog chrysanthemum, Rhizoma Curcumae, Herba Damnacanthi, Ipomoea hungaiensis Lingelsh. Et Borza., Poria, Semen Benincasae, Radix Asteris, Bombyx Batryticatus, Herba Violae dissectae, Herba Sonchi Arvensis, Herba Sarcandrae, Radix Rumicis Patientiae, Caulis Piperis Kadsurae, Radix Notoginseng, Sargassum, Catechu and Radix Glycyrrhizae.

2. Chinese medicine according to claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Ophiopogonis 20-30 part, Rhizoma Anemarrhenae 20-30 part, Rhizoma Phragmitis 15-20 part, red Chen Ai 6-9 part, hedgehog chrysanthemum 6-9 part, Rhizoma Curcumae 6-9 part, Herba Damnacanthi 15-25 part, Ipomoea hungaiensis Lingelsh. Et Borza. 15-25 part, Poria 6-12 part, Semen Benincasae 15-30 part, Radix Asteris 6-12 part, Bombyx Batryticatus 6-9 part, Herba Violae dissectae 10-15 part, Herba Sonchi Arvensis 6-12 part, Herba Sarcandrae 6-10 part, Radix Rumicis Patientiae 7-12 part, Caulis Piperis Kadsurae 6-9 part, Radix Notoginseng 15-19 part, Sargassum 10-15 part, Catechu 6-9 part and Radix Glycyrrhizae 5-10 part.

3. Chinese medicine according to claim 1 and 2, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Ophiopogonis 25-30 part, Rhizoma Anemarrhenae 25-30 part, Rhizoma Phragmitis 16-20 part, red Chen Ai 6-8 part, hedgehog chrysanthemum 7-9 part, Rhizoma Curcumae 7-9 part, Herba Damnacanthi 15-23 part, Ipomoea hungaiensis Lingelsh. Et Borza. 15-20 part, Poria 8-12 part, Semen Benincasae 20-25 part, Radix Asteris 8-12 part, Bombyx Batryticatus 7-9 part, Herba Violae dissectae 10-15 part, Herba Sonchi Arvensis 6-11 part, Herba Sarcandrae 6-9 part, Radix Rumicis Patientiae 7-10 part, Caulis Piperis Kadsurae 6-8 part, Radix Notoginseng 16-19 part, Sargassum 11-15 part, Catechu 6-8 part and Radix Glycyrrhizae 5-8 part.

4. according to the arbitrary described Chinese medicine of claim 1-3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Ophiopogonis 25 parts, the Rhizoma Anemarrhenae 27 parts, Rhizoma Phragmitis 16 parts, red Chen Ai 6 parts, hedgehog chrysanthemum 9 parts, Rhizoma Curcumae 8 parts, Herba Damnacanthi 21 parts, Ipomoea hungaiensis Lingelsh. Et Borza. 16 parts, 10 parts, Poria, Semen Benincasae 20 parts, Radix Asteris 12 parts, Bombyx Batryticatus 7 parts, Herba Violae dissectae 12 parts, Herba Sonchi Arvensis 6 parts, Herba Sarcandrae 9 parts, Radix Rumicis Patientiae 7 parts, Caulis Piperis Kadsurae 8 parts, Radix Notoginseng 16 parts, Sargassum 15 parts, Catechu 6 parts and 8 parts, Radix Glycyrrhizae.

5. according to the arbitrary described Chinese medicine of claim 1-3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Ophiopogonis 30 parts, the Rhizoma Anemarrhenae 30 parts, Rhizoma Phragmitis 20 parts, red Chen Ai 7 parts, hedgehog chrysanthemum 8 parts, Rhizoma Curcumae 9 parts, Herba Damnacanthi 23 parts, Ipomoea hungaiensis Lingelsh. Et Borza. 15 parts, 8 parts, Poria, Semen Benincasae 25 parts, Radix Asteris 9 parts, Bombyx Batryticatus 8 parts, Herba Violae dissectae 15 parts, Herba Sonchi Arvensis 11 parts, Herba Sarcandrae 7 parts, Radix Rumicis Patientiae 8 parts, Caulis Piperis Kadsurae 7 parts, Radix Notoginseng 17 parts, Sargassum 11 parts, Catechu 7 parts and 6 parts, Radix Glycyrrhizae.

6. according to the arbitrary described Chinese medicine of claim 1-3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Ophiopogonis 28 parts, the Rhizoma Anemarrhenae 25 parts, Rhizoma Phragmitis 18 parts, red Chen Ai 8 parts, hedgehog chrysanthemum 7 parts, Rhizoma Curcumae 7 parts, Herba Damnacanthi 15 parts, Ipomoea hungaiensis Lingelsh. Et Borza. 21 parts, 12 parts, Poria, Semen Benincasae 22 parts, Radix Asteris 8 parts, Bombyx Batryticatus 9 parts, Herba Violae dissectae 10 parts, Herba Sonchi Arvensis 7 parts, Herba Sarcandrae 6 parts, Radix Rumicis Patientiae 10 parts, Caulis Piperis Kadsurae 6 parts, Radix Notoginseng 19 parts, Sargassum 12 parts, Catechu 8 parts and 5 parts, Radix Glycyrrhizae.

7., according to the arbitrary described Chinese medicine of claim 1-6, it is characterized in that, when the dosage form of described Chinese medicine is spray, its preparation method comprises the following steps:

A, take all raw medicinal materials in described ratio, add relative to the mixture quality 3-5 obtained water soaking 3-10 hour doubly, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, decoct 3 times, merge decoction liquor to filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;

B, the medicinal residues of step a are added 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid, 80-160 order filters, get 6000-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;

C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.