CN104623222A - Traditional Chinese medicine composition with effects of clearing away heat and toxic materials for treating breast cancer and preparation method thereof - Google Patents
Traditional Chinese medicine composition with effects of clearing away heat and toxic materials for treating breast cancer and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition with effects of clearing away heat and toxic materials for treating breast cancer. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 8-14 parts of mother chrysanthemum, 10-15 parts of Utricularia bifida, 9-14 parts of Isodon amethystoides, 12-16 parts of pungent litse branchlet, 14-19 parts of liquorice, 13-16 parts of hypericum sampsonii hance, 10-14 parts of phoenix-tail fern, 9-16 parts of hylomecon japonica, 12-18 parts of the seed of cowherb, 14-18 parts of small diuranthera root, 8-15 parts of Daphne odora, 9-16 parts of Indian melothria root, 15-18 parts of Mangnolia officinalis and 12-15 parts of perilla leaf. The traditional Chinese medicine composition disclosed by the invention has excellent effects that the traditional drug properties are organically combined with the modern pharmacology of traditional Chinese medicine, the main treatment principle of strengthening the body resistance, detoxicating and promoting the secretion of saliva or body fluid is achieved, accelerated re-proliferation of tumor cells is overcome, and metastasis and transfer of tumors are effectively inhibited; and moreover, according to the medicine, the clinical symptoms of patients are improved, pain is alleviated, the immunity of the body can be obviously enhanced, and the curative effect is exact.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of heat-clearing and detoxifying herb composition and method of making the same for the treatment of breast carcinoma.
Background technology
Breast carcinoma usually occurs in breast epithelial tissue, is one of modal malignant tumor of women, occupies first of female malignant.In recent years, along with the acceleration of global industry process, some developing countries, comprise China, and the sickness rate of breast carcinoma has started to present the trend obviously risen.The whole world about has more than 150 ten thousand women to be diagnosed as breast carcinoma every year, and has more than 40 ten thousand people dead.U.S.'s disease surveillance center statistics is pointed out, the cure rate after breast cancer progression only has about 40%, and as can be seen here, breast carcinoma drastically influence the physical and mental health of women, even threat to life.
Breast carcinoma is called as " breast carcinoma ", " mammary calculus carbuncle " etc. in TCM Document in ancient times.Record to " stone carbuncle " in " General Treatise on the Cause and Symptoms of Diseases stone carbuncle time ": " stone carbuncle person is also that cold visitor is in muscle ... its swollen knot really, has root to jail, the skin-deep parent of core, very not hot, and hypodynia, from having a rest during heat ... steam takes advantage of it for a long time, and being has pus also ".About the record of breast carcinoma etiology and pathogenesis in " the sweet core case of fourth ": " depressed emotion, strongly fragrant and light a fire, stagnated fire folder blood stasis condensation; battalion Wei Bucong ", think that internal damage by the excessive seven emotions or diseases caused by exogenous pathogenic factor six climate exopathogens with the passing of time all can fire-transformation, pathogenic heat fire toxin stagnation is in interior, gather and do not go, gradually become lump in the course of time.Therefore with heat-clearing and toxic substances removing, nourishing YIN to lower pathogenic fire for Therapeutic Principle.Also someone thinks, human righteousness's virtual loss, then not all right, Tianjin not cloth of blood, easily forms the expectorant stasis of blood; Healthy energy virtual loss is evil to become poison, and expectorant ecchymosis is poly-then easily forms cancer.Therefore, in treatment, we think based on heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.
Application publication number CN 104288665 A(application number 201410628232.1) Chinese invention patent document disclose a kind of granule for the treatment of breast carcinoma, be made up of the component of following weight portion: Herba Scutellariae Barbatae 5-15 part, xanthorrhiza 15-25 part, Radix Ginseng 10-20 part, Herba Dendrobii 10-20 part, Herba Houttuyniae 15-25 part, Radix Aucklandiae 5-15 part, vanillin 15-25 part, Radix Paeoniae Rubra 10-20 part, Radix Puerariae 5-15 part, Rhizoma Chuanxiong 5-15 part, Radix Glycyrrhizae Preparata 10-20 part, Matrii Sulfas Exsiccatus 5-15 part, Fructus Amomi 10-20 part.Application publication number CN 102973892 A(application number 201210525984.6) Chinese invention patent document disclose a kind of Chinese medicine composition for the treatment of breast carcinoma, be prepared from by following raw material medicaments: Radix Angelicae Sinensis 15g, Squama Manis (processed) 10g, Bulbus Fritillariae Cirrhosae 15g, Radix Paeoniae Rubra 10g, Radix Rehmanniae 10g, Semen Vaccariae 10g, Rhizoma Cyperi 10g, Rhizoma Curcumae 10g, Radix Platycodonis 8g, Flos Carthami 15g, Semen Coicis 15g, Olibanum (processed) 10g, Myrrha 10g, Radix Glycyrrhizae 6g, Pseudobulbus Cremastrae Seu Pleiones 10g, Ganoderma 10g and Radix Curcumae 10g.Application publication number CN 104127818 A(application number 201410367225.0) Chinese invention patent document disclose a kind of Chinese medicine preparation for the treatment of breast carcinoma, be prepared from by the crude drug of following weight portion: Spica Prunellae 10-20 gram, Radix Trichosanthis 10-20 gram, Sargassum 10-20 gram, Flos Carthami 5-10 gram, Herba Taraxaci 5-10 gram, Radix Notoginseng 8-12 gram, Radix Scrophulariae 8-15 gram, Scorpio 10-20 gram, Bombyx Batryticatus 8-12 gram, Radix Curcumae 5-10 gram, Rhizoma Atractylodis Macrocephalae 10-20 gram, Squama Manis 5-10 gram.
The western medical treatment of current breast carcinoma still based on operation, the treatments such as Combined with Radiotherapy chemotherapy, endocrine therapy and biological targeting.But chemicotherapy can bring a lot of toxic and side effects and untoward reaction, occurs drug resistance etc.Mammary Cancer Treated by Chinese Medicine effect is gentle lasting, not only can improve the symptom of patient, improve the quality of living; And the coefficient of stabilization at a specified future date of tumor body is higher, without obvious toxic-side effects, alleviate the stress of patient, medical expense is relative moderate also.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare the heat-clearing and detoxifying herb compositions simply, conveniently taking, treat safely and effectively breast carcinoma.Chinese medicine composition of the present invention is evident in efficacy, is convenient to clinical practice.
Technical scheme of the present invention is:
Treat a heat-clearing and detoxifying herb compositions for breast carcinoma, be prepared from by following bulk drugs, be weight portion: Flos Chrysanthemi Indici 8-14; Herba Carpesii Cernui 10-15; Herba Rabdosiae glaucocalycis 9-14; Caulis Litseae pungentis 12-16; Radix Glycyrrhizae 14-19; Herba Hyperici Sampsonii 13-16; Herba Pteridis Multifidae 10-14; Radix Hylomeci japonicae 9-16; Semen Vaccariae 12-18; Radix Diurantherae Minoris 14-18; Winter daphne 8-15; Radix Melothriae Heterophyllae 9-16; Cortex Magnoliae Officinalis 15-18; Folium Perillae 12-15.
In preferred scheme, Flos Chrysanthemi Indici 10-12; Herba Carpesii Cernui 11-14; Herba Rabdosiae glaucocalycis 11-12; Caulis Litseae pungentis 13-15; Radix Glycyrrhizae 15-18; Herba Hyperici Sampsonii 14-15; Herba Pteridis Multifidae 11-13; Radix Hylomeci japonicae 11-14; Semen Vaccariae 14-16; Radix Diurantherae Minoris 15-17; Winter daphne 10-13; Radix Melothriae Heterophyllae 11-14; Cortex Magnoliae Officinalis 16-17; Folium Perillae 13-14.
Be more preferably, Flos Chrysanthemi Indici 11; Herba Carpesii Cernui 12.5; Herba Rabdosiae glaucocalycis 11.5; Caulis Litseae pungentis 14; Radix Glycyrrhizae 16.5; Herba Hyperici Sampsonii 14.5; Herba Pteridis Multifidae 12; Radix Hylomeci japonicae 12.5; Semen Vaccariae 15; Radix Diurantherae Minoris 16; Winter daphne 11.5; Radix Melothriae Heterophyllae 12.5; Cortex Magnoliae Officinalis 16.5; Folium Perillae 13.5.
Treat a heat-clearing and detoxifying herb compositions for breast carcinoma, be made into pharmaceutically acceptable capsule, preparation method is as follows:
(1) immerse in Oleum Sesami by Radix Glycyrrhizae tabellae, make two sides all stick Oleum Sesami, take out at once, be placed in hot pot, slow fire heats, and roast the golden yellow slightly focal spot to two sides, taking-up cools, and smashs to pieces for subsequent use; Semen Vaccariae is put in frying pan, and moderate heat heats, and fry to burst into major part and spend in vain, taking-up cools, and smashs to pieces for subsequent use; Flos Chrysanthemi Indici, Folium Perillae magnolia obovata are ground into fine powder respectively, for subsequent use;
(2) step (1) gained raw material medicated powder is mixed, sieve for subsequent use;
(3) crude drug except Radix Glycyrrhizae, Semen Vaccariae, Flos Chrysanthemi Indici, Folium Perillae magnolia obovata is placed in Chinese medicine pan, adds the distilled water (preferably adding the distilled water of 9 times amount) of 8-10 times amount, soak 1.3-2.7 hour, after intense fire boils, turn slow fire boiling 1.2-2.8 hour, filter, obtain decocting liquid; Add the distilled water (preferably adding the distilled water of 5 times amount again) of 4-6 times amount again, change slow fire boiling 38-52 minute after intense fire boils (preferably this slow fire boiling 45 minutes), filter, merge twice decocting liquid;
(4) above-mentioned decocting liquid being evaporated to 90 DEG C of relative densities is the thick paste of 1.32-1.35; Add step (2) gained mixing fine powders, stir, add sucrose fine and the hydroxypropyl methylcellulose of 15% mass parts, mixing, granulate, dry, incapsulate shell, to obtain final product.
Above-mentioned a kind of preparation method for the treatment of the heat-clearing and detoxifying herb capsule of breast carcinoma, preferred scheme is, the middle 100-140 mesh sieve excessively of step (2) (preferred 110-130 mesh sieve excessively, mistake 120 mesh sieve be more preferably).
Above-mentioned a kind of preparation method for the treatment of the heat-clearing and detoxifying herb capsule of breast carcinoma, preferred scheme is, soaks 1.7-2.3 hour (preferably soaking 2.0 hours) in step (3).
Above-mentioned a kind of preparation method for the treatment of the heat-clearing and detoxifying herb capsule of breast carcinoma, preferred scheme is, step (3) transfer slow fire boiling 1.6-2.4 hour (preferred slow fire boiling 2.0 hours).
The preparation method of described decoction is:
(1) Flos Chrysanthemi Indici, Folium Perillae magnolia obovata are placed in frying pan, add clear water and do not have powder, big fire heated and boiled, turn moderate heat and decoct 22-34 minute (preferably turn moderate heat and decoct 28 minutes), filter, obtain decocting liquid;
(2) crude drug except Flos Chrysanthemi Indici, Folium Perillae magnolia obovata is placed in Chinese medicinal pot, the clear water adding 5-10 times amount soaks 1.5-3.5 hour (clear water preferably adding 8 times amount soaks 2.5 hours), intense fire is heated to boil, turn slow fire boiling twice, first time decocts 1-1.5 hour (preferably first time decocts 1.3 hours), second time decocts 38-52 minute (preferably second time decocts 45 minutes), filters, merges twice decocting liquid;
(3) by step (1) and the mixing of step (2) gained decocting liquid, continue to be evaporated to 1/3 of original liquid volume, dry heat sterilization, subpackage, to obtain final product.
The preparation method of described powder is:
(1) each crude drug is placed in thermostatic drying chamber, in 60-70 DEG C of freeze-day with constant temperature 3-5 hour (being preferable over 65 DEG C of freeze-day with constant temperature 4 hours), taking out, be ground into fine powder;
(2) above-mentioned fine powder is fully mixed, cross 70-90 mesh sieve (preferred mistake 80 mesh sieve), carry out subpackage according to the metering (preferably according to the metering of 25 g/ bags) of 20-30g/ bag, to obtain final product.
The preparation method of described tablet is:
(1) each crude drug is placed in thermostatic drying chamber, in 60-70 DEG C of freeze-day with constant temperature 3-5 hour (being preferable over 65 DEG C of freeze-day with constant temperature 4 hours), taking out, be ground into fine powder;
(2) above-mentioned fine powder is crossed 110 mesh sieves, add magnesium stearate and sucrose fine (raw material medicated powder: magnesium stearate: sucrose fine=5:1.7:1.3), stir, tabletted, to obtain final product.
Scientific formula of the present invention, preparation method is simple, taking convenience, safe and effective.In addition, excellent results of the present invention also shows:
1,traditional property of medicine and Chinese medicine modern pharmacology organically combine by the present invention, promote the production of body fluid for primary treatment principle with Fuzheng Jiedu, overcome the acceleration hypertrophy again of tumor cell, the diffusion of effective Tumor suppression and transfer;
2,medicine of the present invention not only improves the clinical symptoms of patient, alleviates misery, and can the immunocompetence of enhancing body significantly, determined curative effect;
3,medicine source of the present invention is easy to get, and medical material is with low cost, and toxic and side effects is little, has higher promotional value.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Flos Chrysanthemi Indici: base is former: be root or the herb of Compositae Dendranthema Flos Chrysanthemi Indici or lavandulaleaf dendranthema herb.The property of medicine: bitter, acrid, cold.Return liver, heart channel.Function cures mainly: heat-clearing and toxic substances removing, improving eyesight.Cure mainly flu, dysentery, carbuncle, furuncle, conjunctival congestion and swelling pain, dizzy, scrofula, eczema.
Herba Carpesii Cernui: base is former: be the herb of feverfew Carpesium cernuum Linn.Nature and flavor: toil, cold.Function cures mainly: heat clearing away, removing toxic substances, detumescence.Control laryngopharynx swelling and pain, tonsillitis, mumps, acute toothache, carbuncle sore tumefacting virus.
Herba Rabdosiae glaucocalycis: base is former: be the herb of labiate Rabdosia japonica.Nature and flavor: " Ningxia Chinese herbal medicine handbook ": " bitter, cool." function cures mainly: 1. " lucky Fructus Kaki Chinese herbal medicine ": " the whole intestinal of stomach invigorating.Control inappetence, dyspepsia." 2. " Ningxia Chinese herbal medicine handbook ": " heat-clearing and toxic substances removing, spleen invigorating are invigorated blood circulation.Control gastritis, hepatitis from the beginning of, cold, fever, amenorrhea, traumatic injury, mastitis, arthralgia, snake bite and insect sting.”
Caulis Litseae pungentis: base is former: be the stem branch of canella Fructus Litseae pungentis.Nature and flavor: " Guizhou folk medicine ": " warm in nature, acrid in the mouth is nontoxic." function cures mainly: " Guizhou folk medicine ": " adjust cold air, the loose stagnation of QI, pain relieving, table acute diseases such as cholera and sunstroke rash, aid digestion.”
Radix Glycyrrhizae: base is former: this product is drying report and the rhizome of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Nature and flavor: sweet are flat.Gui Jing: GUIXIN.Lung, spleen, stomach warp.Effect: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Cure mainly: for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of institute's abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Herba Hyperici Sampsonii: base is former: be the herb of Garcinia maingayii Herba Hyperici Sampsonii.Nature and flavor: toil are cool.Gui Jing: " Traditional Chinese Medicine in Sichuan will ": " enter liver, spleen two warp." function cures mainly: invigorate blood circulation, hemostasis, removing toxic substances.Control haematemesis, epistaxis, menoxenia, falling winks frustrates, carbuncle sore tumefacting virus.
Herba Pteridis Multifidae: base is former: be herb or the root of Pteridaceae plant Herba Pteridis Multifidae.Nature and flavor: lightly seasoned micro-hardship, cold in nature.Gui Jing: " Quanzhou book on Chinese herbal medicine ": " enter kidney, stomach two warp." function cures mainly: clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, subduing swelling and detoxicating.Control icterohepatitis, enteritis, bacillary dysentery, stranguria with turbid discharge, leukorrhagia, spit blood, epistaxis, has blood in stool, hematuria, tonsillitis, parotitis, carbuncle sore tumefacting virus, eczema.
Radix Hylomeci japonicae: base is former: be the root of bloodroot Radix Hylomeci japonicae.Nature and flavor: " Shaanxi Chinese herbal medicine ": " bitter in the mouth, property is put down." function cures mainly: " Shaanxi Chinese herbal medicine ": " wind-damp dispelling, relaxing muscles and tendons and activating QI and blood in the collateral, dissipating blood stasis for subsidence of swelling, analgesic hemostatic.Treating rheumatic arthritis, impairment caused by overstrain, traumatic injury.”
Semen Vaccariae: base is former: be the seed of pinkwort Vaccaria segetalis.Chemical analysis: containing vacsedoside, Semen Vaccariae flavonoid glycoside etc.Nature and flavor: bitter are flat.Gui Jing: enter liver, stomach warp.Function cures mainly: promoting the circulation of blood is stimulated the menstrual flow, and expedites the emergence of stimulating milk secretion, detumescence sore.Control women's amenorrhea, galactostasis, difficult labour, stranguria with blood, carbuncle, incised wound is hemorrhage.
Radix Diurantherae Minoris: base is former: be the root of the little Radix diurantherae majoris of liliaceous plant.Nature and flavor: 1. " Yunnan Chinese herbal medicine ": " light, flat." 2. " Kunming conventional medical herbs among the people ": " sweet, flat." function cures mainly: " Yunnan Chinese herbal medicine ": " heat-clearing and toxic substances removing, strong swollen dampness removing.Dispelling the wind and dampness pathogens, infantile malnutrition, mastitis, venom.”
Winter daphne: base is former: thymelaeceae daphne plant winter daphne, is used as medicine with root, bark, leaf and flower.Nature and flavor: pungent, sweet, temperature.Function cures mainly: expelling wind and removing dampness, promoting blood circulation and stopping pain.For rheumatic arthritis, sciatica, pharyngitis, toothache, breast carcinoma is from the beginning of, traumatic injury.
Radix Melothriae Heterophyllae: base is former: be the root of cucurbitaceous plant horse small melon or thatch melon.Nature and flavor: sweetness and bitterness, cold.Nature and flavor: sweetness and bitterness, cold.Function cures mainly: removing heat-phlegm, dampness removing, mass dissipating and swelling eliminating.Control heat syndrome cough, dysentery, gonorrhea, urinary tract infection, alcoholic jaundice, rheumatic arthralgia, laryngalgia, conjunctival congestion, eczema, carbuncle.
Cortex Magnoliae Officinalis: base is former: this product is the dry dried bark of Magnoliacea plant Cortex Magnoliae Officinalis or magnolia officinalis rehd.et wils.var.biloba rehd.et wils., root bark and branch skin.Nature and flavor: bitter, pungent, temperature.Gui Jing: return spleen, stomach, lung, large intestine channel.Function cures mainly: dampness expectorant, and the therapeutic method to keep the adverse QI flowing downwards is except full.For humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.
Folium Perillae: base is former: be the leaf of labiate wrinkle Folium Perillae, sharp Folium Perillae etc.Chemical analysis: wrinkle Folium Perillae herb, containing volatile oil about 0.5%, includes perillaldehyde about 55%, left-handed limonene 20 ~ 30% and australene a small amount of.Also contain arginine, cumfrey, cyanidin 3-(6-to coumaric acyl-β-D-Glucose glycoside) 5-β-D-Glucose glycoside.Pharmacological action: 1. refrigeration function; 2. antibacterial action.Nature and flavor: pungent, temperature.Gui Jing: enter lung, spleen channel.Function cures mainly: deliver, and cold expelling is regulated the flow of vital energy, and battalion.Cure cold wind and cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen, frequent fetal movement.And can solving toxin of fish and crab.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1treat a heat-clearing and detoxifying herb compositions for breast carcinoma, be prepared from by following bulk drugs, be weight portion (70g/ part): Flos Chrysanthemi Indici 8 parts; Herba Carpesii Cernui 10 parts; Herba Rabdosiae glaucocalycis 9 parts; Caulis Litseae pungentis 12 parts; 14 parts, Radix Glycyrrhizae; Herba Hyperici Sampsonii 13 parts; Herba Pteridis Multifidae 10 parts; Radix Hylomeci japonicae 9 parts; Semen Vaccariae 12 parts; Radix Diurantherae Minoris 14 parts; Winter daphne 8 parts; Radix Melothriae Heterophyllae 9 parts; Cortex Magnoliae Officinalis 15 parts; Folium Perillae 12 parts.
Above-mentioned a kind of preparation method for the treatment of the heat-clearing and detoxifying herb capsule of breast carcinoma is:
(1) immerse in Oleum Sesami by Radix Glycyrrhizae tabellae, make two sides all stick Oleum Sesami, take out at once, be placed in hot pot, slow fire heats, and roast the golden yellow slightly focal spot to two sides, taking-up cools, and smashs to pieces for subsequent use; Semen Vaccariae is put in frying pan, and moderate heat heats, and fry to burst into major part and spend in vain, taking-up cools, and smashs to pieces for subsequent use; Flos Chrysanthemi Indici, Folium Perillae magnolia obovata are ground into fine powder respectively, for subsequent use;
(2) step (1) gained raw material medicated powder is mixed, cross 100 mesh sieves, for subsequent use;
(3) crude drug except Radix Glycyrrhizae, Semen Vaccariae, Flos Chrysanthemi Indici, Folium Perillae magnolia obovata is placed in Chinese medicine pan, adds the distilled water of 9 times amount, soak 1.3 hours, after intense fire boils, turn slow fire boiling 1.2 hours, filter, obtain decocting liquid; Add the distilled water of 4 times amount again, change slow fire boiling after intense fire boils 38 minutes, filter, merge twice decocting liquid;
(4) above-mentioned decocting liquid being evaporated to 90 DEG C of relative densities is the thick paste of 1.32-1.35; Add step (2) gained mixing fine powders, stir, add sucrose fine and the hydroxypropyl methylcellulose of 15% mass parts, mixing, granulate, dry, incapsulate shell, to obtain final product.
The instructions of taking of capsule of the present invention is: every day three times, each 7-10 grain, and warm water takes, 30 days courses for the treatment of.
Model case a: XX, female, 49 years old, people from Henan.The Ms Zhang the year before outside upper quadrant of left breast finds the hard Silent Neuritis lump of a matter, diameter about 2.0 centimetres, light activity, and Ms Zhang thinks that lump understands oneself soon and disappears, all not attention.Felt that lump increased gradually afterwards, hardening, pressing without pain, and found that before half a year nipple starts to cave in and fixes, and recently, Ms Zhang feels again the symptoms such as the appearance of left laitance skin is red, swollen, hot, pain, and left nipple can extrude a small amount of brown liquid.It is tumor that Ms Zhang worries, by making some inquiries about, to our hospital in December in 2010 9 days.Check: 5.2 centimetres, patient's left swelling of the breast block length footpath, minor axis 3.6 centimetres, matter is hard, true feeling, left retracted nipple, fixing, can extrude yellowish-brown turbid liquid.Mammography: the huge matter of left swelling of the breast block is hard, cannot take; Be breast carcinoma in conjunction with clinical diagnosis.
Take a kind of heat-clearing and detoxifying herb capsule for the treatment of breast carcinoma of the present embodiment gained, instructions of taking: every day three times, each 7-10 grain, warm water takes, 30 days courses for the treatment of.After treating two courses for the treatment of, patients symptomatic and sign obviously alleviate; Two courses for the treatment of of continual cure, check and find that the left swelling of the breast block of patient disappears substantially, patient cures substantially.Take the medicine of a course for the treatment of again with consolidate curative effect.Follow up a case by regular visits to after half a year, without recurrence.
embodiment 2treat a heat-clearing and detoxifying herb compositions for breast carcinoma, be prepared from by following bulk drugs, be weight portion (50g/ part): Flos Chrysanthemi Indici 14 parts; Herba Carpesii Cernui 15 parts; Herba Rabdosiae glaucocalycis 14 parts; Caulis Litseae pungentis 16 parts; 19 parts, Radix Glycyrrhizae; Herba Hyperici Sampsonii 16 parts; Herba Pteridis Multifidae 14 parts; Radix Hylomeci japonicae 16 parts; Semen Vaccariae 18 parts; Radix Diurantherae Minoris 18 parts; Winter daphne 15 parts; Radix Melothriae Heterophyllae 16 parts; Cortex Magnoliae Officinalis 18 parts; Folium Perillae 15 parts.
The preparation method that above-mentioned kind treats the heat-clearing and detoxifying herb decoction of breast carcinoma is:
(1) Flos Chrysanthemi Indici, Folium Perillae magnolia obovata are placed in frying pan, add clear water and do not have powder, big fire heated and boiled, turn moderate heat and decoct 28 minutes, filter, obtain decocting liquid;
(2) crude drug except Flos Chrysanthemi Indici, Folium Perillae magnolia obovata is placed in Chinese medicinal pot, the clear water adding 8 times amount soaks 2.5 hours, and intense fire is heated to boil, turn slow fire boiling twice, first time decocts 1.3 hours, and second time decocts 45 minutes, filter, merge twice decocting liquid;
(3) by step (1) and the mixing of step (2) gained decocting liquid, continue to be evaporated to 1/3 of original liquid volume, dry heat sterilization, subpackage, to obtain final product.
The instructions of taking of decoction of the present invention is: once a day, each 200-250mL, warmly takes, and within 30 days, is a course for the treatment of.
embodiment 3treat a heat-clearing and detoxifying herb compositions for breast carcinoma, be prepared from by following bulk drugs, be weight portion (65g/ part): Flos Chrysanthemi Indici 12 parts; Herba Carpesii Cernui 14 parts; Herba Rabdosiae glaucocalycis 12 parts; Caulis Litseae pungentis 15 parts; 18 parts, Radix Glycyrrhizae; Herba Hyperici Sampsonii 15 parts; Herba Pteridis Multifidae 13 parts; Radix Hylomeci japonicae 14 parts; Semen Vaccariae 16 parts; Radix Diurantherae Minoris 17 parts; Winter daphne 13 parts; Radix Melothriae Heterophyllae 14 parts; Cortex Magnoliae Officinalis 17 parts; Folium Perillae 14 parts.
Above-mentioned a kind of preparation method for the treatment of the heat-clearing and detoxifying herb powder of breast carcinoma is:
(1) each crude drug is placed in thermostatic drying chamber, in 65 DEG C of freeze-day with constant temperature 4 hours, takes out, be ground into fine powder;
(2) above-mentioned fine powder is fully mixed, cross 80 mesh sieves, carry out subpackage according to the metering of 25 g/ bags, to obtain final product.
The instructions of taking of powder of the present invention is: every day three times, each 10-15g, and hot water is taken after mixing it with water, 30 days courses for the treatment of.
Model case: poplar XX, female, 51 years old, people from Jinan.Patient's readme: chancing on right breast before 1 year has a lump, that touches is removable, does not take any remedy measures at that time; Found before half a year that lump obviously becomes large, festering appears in surrounding skin, is diagnosed as breast carcinoma of early stage in local hospital inspection, and carries out chemotherapy.After three courses for the treatment of of chemotherapy, patients symptomatic obviously alleviates, but recurs again after one month, excessive because worrying the injury of chemotherapy to health, and household advises adopting Chinese traditional treatment.After being introduced, come my institute on July 22nd, 2012 and check treatment.Through breast pathocytology and imaging examination, it is errorless to be diagnosed as breast carcinoma.
Take a kind of heat-clearing and detoxifying herb powder for the treatment of breast carcinoma of the present embodiment gained, instructions of taking: every day three times, each 10-15g, hot water is taken after mixing it with water, 30 days courses for the treatment of.After treating two courses for the treatment of, patient's lump starts to reduce, and other symptoms and sign obviously alleviate; After continuing two courses for the treatment of of medication, patient's lump disappears, and patients symptomatic removes, and checks after half a year, without recurrence.
embodiment 4treat a heat-clearing and detoxifying herb compositions for breast carcinoma, be prepared from by following bulk drugs, be weight portion (55g/ part): Flos Chrysanthemi Indici 12 parts; Herba Carpesii Cernui 14 parts; Herba Rabdosiae glaucocalycis 12 parts; Caulis Litseae pungentis 15 parts; 18 parts, Radix Glycyrrhizae; Herba Hyperici Sampsonii 15 parts; Herba Pteridis Multifidae 13 parts; Radix Hylomeci japonicae 14 parts; Semen Vaccariae 16 parts; Radix Diurantherae Minoris 17 parts; Winter daphne 13 parts; Radix Melothriae Heterophyllae 14 parts; Cortex Magnoliae Officinalis 17 parts; Folium Perillae 14 parts.
Above-mentioned a kind of preparation method for the treatment of the heat-clearing and detoxifying herb tablet of breast carcinoma is:
(1) each crude drug is placed in thermostatic drying chamber, in 65 DEG C of freeze-day with constant temperature 4 hours, takes out, be ground into fine powder;
(2) above-mentioned fine powder is crossed 110 mesh sieves, add magnesium stearate and sucrose fine (raw material medicated powder: magnesium stearate: sucrose fine=5:1.7:1.3), stir, tabletted, to obtain final product.
The instructions of taking of Tablets is: every day three times, each 5-8 sheet, and warm water takes, 30 days courses for the treatment of.
embodiment 5treat a heat-clearing and detoxifying herb compositions for breast carcinoma, be prepared from by following bulk drugs, be weight portion (60g/ part): Flos Chrysanthemi Indici 11 parts; Herba Carpesii Cernui 12.5 parts; Herba Rabdosiae glaucocalycis 11.5 parts; Caulis Litseae pungentis 14 parts; 16.5 parts, Radix Glycyrrhizae; Herba Hyperici Sampsonii 14.5 parts; Herba Pteridis Multifidae 12 parts; Radix Hylomeci japonicae 12.5 parts; Semen Vaccariae 15 parts; Radix Diurantherae Minoris 16 parts; Winter daphne 11.5 parts; Radix Melothriae Heterophyllae 12.5 parts; Cortex Magnoliae Officinalis 16.5 parts; Folium Perillae 13.5 parts.
Above-mentioned a kind of preparation method for the treatment of the heat-clearing and detoxifying herb capsule of breast carcinoma is:
(1) immerse in Oleum Sesami by Radix Glycyrrhizae tabellae, make two sides all stick Oleum Sesami, take out at once, be placed in hot pot, slow fire heats, and roast the golden yellow slightly focal spot to two sides, taking-up cools, and smashs to pieces for subsequent use; Semen Vaccariae is put in frying pan, and moderate heat heats, and fry to burst into major part and spend in vain, taking-up cools, and smashs to pieces for subsequent use; Flos Chrysanthemi Indici, Folium Perillae magnolia obovata are ground into fine powder respectively, for subsequent use;
(2) step (1) gained raw material medicated powder is mixed, sieve for subsequent use;
(3) crude drug except Radix Glycyrrhizae, Semen Vaccariae, Flos Chrysanthemi Indici, Folium Perillae magnolia obovata is placed in Chinese medicine pan, adds the distilled water of 9 times amount, soak 2.0 hours, after intense fire boils, turn slow fire boiling 2.0 hours, filter, obtain decocting liquid; Add the distilled water of 5 times amount again, change slow fire boiling after intense fire boils 45 minutes, filter, merge twice decocting liquid;
(4) above-mentioned decocting liquid being evaporated to 90 DEG C of relative densities is the thick paste of 1.32-1.35; Add step (2) gained mixing fine powders, stir, add sucrose fine and the hydroxypropyl methylcellulose of 15% mass parts, mixing, granulate, dry, incapsulate shell, to obtain final product.
The instructions of taking of capsule of the present invention is: every day three times, each 7-10 grain, and warm water takes, 30 days courses for the treatment of.
test example 1a kind of clinical practice for the treatment of the heat-clearing and detoxifying herb compositions (embodiment 5) of breast carcinoma of gained of the present invention:
1 data and method
1.1 physical data
Choosing mammary gland patient totally 320 examples that in April, 2010, in December ,-2013 was accepted for medical treatment 5 years old hospital's oncology, is all female patient, wherein max age 68 years old, minimal ages 33 years old, 51.5 years old mean age.
1.2 case inclusive criterias
(1) pathology or cytology clarify a diagnosis as the patient of breast carcinoma; (2) do not carry out chemicotherapy or stop the chemicotherapy time to be greater than three months;
1.3 curative effect determinate standard
Clinical cure: clinical symptoms and the sign of patient disappear completely, lump disappears, and produces without new tumor; Effective: clinical symptoms and sign partial disappearance or obviously alleviate, mass reduction is over half, and produces without new tumor; Effective: clinical symptoms and sign alleviate to some extent, and mass reduction is less than 50%; Invalid: unchanged or aggravation after treatment.(total effective rate=clinical cure rate+obvious effective rate+effective percentage)
1.4 Therapeutic Method
All patients are divided into treatment group and matched group at random, and two groups of patients, in age, the state of an illness etc., through statistical procedures no significant difference (P > 0.05), have comparability.Wherein treatment group takes gained medicine of the present invention, observes four courses for the treatment of of treatment altogether.Matched group uses other drug (as tamoxifen, the precious medicine such as capsule and XIHUANG WAN of stilbene).
1.5 therapeutic outcome
Result is as shown in table 1.
Table 1: take embodiment 5 product 33-68 year Breast Cancer Patients Treated result
Therapeutic effect: treatment group total effective rate is 92.9%, and matched group total effective rate is 72.7%.It can thus be appreciated that treatment group successful is better than matched group.
The present invention by Flos Chrysanthemi Indici, Herba Carpesii Cernui, Herba Rabdosiae glaucocalycis, Caulis Litseae pungentis, Radix Glycyrrhizae, Herba Hyperici Sampsonii, Herba Pteridis Multifidae, Radix Hylomeci japonicae, Semen Vaccariae, Radix Diurantherae Minoris, winter daphne and Radix Melothriae Heterophyllae etc. totally 14 taste primary raw materials be prepared from.In side, Flos Chrysanthemi Indici has effect of heat-clearing and toxic substances removing; Herba Carpesii Cernui heat clearing away, removing toxic substances, detumescence; Herba Rabdosiae glaucocalycis heat-clearing and toxic substances removing, spleen invigorating, invigorates blood circulation; Caulis Litseae pungentis adjusts cold air, the loose stagnation of QI, pain relieving; Herba Hyperici Sampsonii is invigorated blood circulation, hemostasis, removing toxic substances; Herba Pteridis Multifidae clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating; Radix Hylomeci japonicae wind-damp dispelling, relaxing muscles and tendons and activating QI and blood in the collateral, dissipating blood stasis for subsidence of swelling; Radix Diurantherae Minoris, winter daphne, Radix Melothriae Heterophyllae heat-clearing and toxic substances removing, mass dissipating and swelling eliminating, strong swollen dampness removing; Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.All medicine compatibilities, bring out the best in each other, and play the merit of the body resistance strengthening and constitution consolidating, benefiting QI and nourishing blood, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing altogether.After treating three courses for the treatment of, total effective rate is 92.9%, Be very effective.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat a heat-clearing and detoxifying herb compositions for breast carcinoma, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Flos Chrysanthemi Indici 8-14; Herba Carpesii Cernui 10-15; Herba Rabdosiae glaucocalycis 9-14; Caulis Litseae pungentis 12-16; Radix Glycyrrhizae 14-19; Herba Hyperici Sampsonii 13-16; Herba Pteridis Multifidae 10-14; Radix Hylomeci japonicae 9-16; Semen Vaccariae 12-18; Radix Diurantherae Minoris 14-18; Winter daphne 8-15; Radix Melothriae Heterophyllae 9-16; Cortex Magnoliae Officinalis 15-18; Folium Perillae 12-15.
2. a kind of heat-clearing and detoxifying herb compositions for the treatment of breast carcinoma as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Flos Chrysanthemi Indici 10-12; Herba Carpesii Cernui 11-14; Herba Rabdosiae glaucocalycis 11-12; Caulis Litseae pungentis 13-15; Radix Glycyrrhizae 15-18; Herba Hyperici Sampsonii 14-15; Herba Pteridis Multifidae 11-13; Radix Hylomeci japonicae 11-14; Semen Vaccariae 14-16; Radix Diurantherae Minoris 15-17; Winter daphne 10-13; Radix Melothriae Heterophyllae 11-14; Cortex Magnoliae Officinalis 16-17; Folium Perillae 13-14.
3. a kind of heat-clearing and detoxifying herb compositions for the treatment of breast carcinoma as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Flos Chrysanthemi Indici 11; Herba Carpesii Cernui 12.5; Herba Rabdosiae glaucocalycis 11.5; Caulis Litseae pungentis 14; Radix Glycyrrhizae 16.5; Herba Hyperici Sampsonii 14.5; Herba Pteridis Multifidae 12; Radix Hylomeci japonicae 12.5; Semen Vaccariae 15; Radix Diurantherae Minoris 16; Winter daphne 11.5; Radix Melothriae Heterophyllae 12.5; Cortex Magnoliae Officinalis 16.5; Folium Perillae 13.5.
4. a kind of heat-clearing and detoxifying herb compositions for the treatment of breast carcinoma as described in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable capsule, preparation method is as follows:
(1) immerse in Oleum Sesami by Radix Glycyrrhizae tabellae, make two sides all stick Oleum Sesami, take out at once, be placed in hot pot, slow fire heats, and roast the golden yellow slightly focal spot to two sides, taking-up cools, and smashs to pieces for subsequent use; Semen Vaccariae is put in frying pan, and moderate heat heats, and fry to burst into major part and spend in vain, taking-up cools, and smashs to pieces for subsequent use; Flos Chrysanthemi Indici, Folium Perillae magnolia obovata are ground into fine powder respectively, for subsequent use;
(2) step (1) gained raw material medicated powder is mixed, sieve for subsequent use;
(3) crude drug except Radix Glycyrrhizae, Semen Vaccariae, Flos Chrysanthemi Indici, Folium Perillae magnolia obovata is placed in Chinese medicine pan, adds the distilled water (preferably adding the distilled water of 9 times amount) of 8-10 times amount, soak 1.3-2.7 hour, after intense fire boils, turn slow fire boiling 1.2-2.8 hour, filter, obtain decocting liquid; Add the distilled water (preferably adding the distilled water of 5 times amount again) of 4-6 times amount again, change slow fire boiling 38-52 minute after intense fire boils (preferably this slow fire boiling 45 minutes), filter, merge twice decocting liquid;
(4) above-mentioned decocting liquid being evaporated to 90 DEG C of relative densities is the thick paste of 1.32-1.35; Add step (2) gained mixing fine powders, stir, add sucrose fine and the hydroxypropyl methylcellulose of 15% mass parts, mixing, granulate, dry, incapsulate shell, to obtain final product.
5. a kind of heat-clearing and detoxifying herb capsule for the treatment of breast carcinoma according to claim 4, is characterized in that, the middle 100-140 mesh sieve excessively of step (2) (preferred 110-130 mesh sieve excessively, mistake 120 mesh sieve be more preferably).
6. a kind of heat-clearing and detoxifying herb capsule for the treatment of breast carcinoma according to claim 4, is characterized in that, soaks 1.7-2.3 hour (preferably soaking 2.0 hours) in step (3).
7. a kind of heat-clearing and detoxifying herb capsule for the treatment of breast carcinoma according to claim 4, is characterized in that, step (3) transfer slow fire boiling 1.6-2.4 hour (preferred slow fire boiling 2.0 hours).
8. a kind of heat-clearing and detoxifying herb compositions for the treatment of breast carcinoma as described in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable decoction, preparation method is as follows:
(1) Flos Chrysanthemi Indici, Folium Perillae magnolia obovata are placed in frying pan, add clear water and do not have powder, big fire heated and boiled, turn moderate heat and decoct 22-34 minute (preferably turn moderate heat and decoct 28 minutes), filter, obtain decocting liquid;
(2) crude drug except Flos Chrysanthemi Indici, Folium Perillae magnolia obovata is placed in Chinese medicinal pot, the clear water adding 5-10 times amount soaks 1.5-3.5 hour (clear water preferably adding 8 times amount soaks 2.5 hours), intense fire is heated to boil, turn slow fire boiling twice, first time decocts 1-1.5 hour (preferably first time decocts 1.3 hours), second time decocts 38-52 minute (preferably second time decocts 45 minutes), filters, merges twice decocting liquid;
(3) by step (1) and the mixing of step (2) gained decocting liquid, continue to be evaporated to 1/3 of original liquid volume, dry heat sterilization, subpackage, to obtain final product.
9. a kind of heat-clearing and detoxifying herb compositions for the treatment of breast carcinoma as described in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable powder, preparation method is as follows:
(1) each crude drug is placed in thermostatic drying chamber, in 60-70 DEG C of freeze-day with constant temperature 3-5 hour (being preferable over 65 DEG C of freeze-day with constant temperature 4 hours), taking out, be ground into fine powder;
(2) above-mentioned fine powder is fully mixed, cross 70-90 mesh sieve (preferred mistake 80 mesh sieve), carry out subpackage according to the metering (preferably according to the metering of 25 g/ bags) of 20-30g/ bag, to obtain final product.
10. a kind of heat-clearing and detoxifying herb compositions for the treatment of breast carcinoma as described in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable tablet, preparation method is as follows:
(1) each crude drug is placed in thermostatic drying chamber, in 60-70 DEG C of freeze-day with constant temperature 3-5 hour (being preferable over 65 DEG C of freeze-day with constant temperature 4 hours), taking out, be ground into fine powder;
(2) above-mentioned fine powder is crossed 110 mesh sieves, add magnesium stearate and sucrose fine (raw material medicated powder: magnesium stearate: sucrose fine=5:1.7:1.3), stir, tabletted, to obtain final product.
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