CN107753879A - The Chinese medicine composition and its preparation method of a kind of reducing blood lipid - Google Patents

The Chinese medicine composition and its preparation method of a kind of reducing blood lipid Download PDF

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CN107753879A
CN107753879A CN201711290203.9A CN201711290203A CN107753879A CN 107753879 A CN107753879 A CN 107753879A CN 201711290203 A CN201711290203 A CN 201711290203A CN 107753879 A CN107753879 A CN 107753879A
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chinese medicine
medicine composition
blood
effect
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唐佳艳
刘晓红
王志军
刘建军
孙林
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唐佳艳
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/646Arachnids, e.g. spiders, scorpions, ticks or mites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486Millettia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708Rheum (rhubarb)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • A61K36/8988Gastrodia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9066Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger

Abstract

The present invention relates to a kind of Chinese medicine composition of reducing blood lipid and its preparation method, the raw material that the Chinese medicine composition includes following weight proportion forms:140~160 parts of the red sage root, 140~160 parts of turmeric, 140~160 parts of Fructus Aurantii, 140~160 parts of reticulate millettia, 90~110 parts of the Radix Astragali, 90~110 parts of ilex pubescens, 80~100 parts of rhizoma Gastrodiae, 80~100 parts of rheum officinale, 80~100 parts of luffa, 80~100 parts of cassia twig, 50~70 parts of stiff silkworm, 50~70 parts of scorpio;The Chinese medicine composition has promoting qi circulation and relieving pain, disperse blood stasis and dredge collateral, benefiting qi and nourishing blood, the work(of dissipating phlegm for resuscitation, clinically has the effect of notable for the patient of high fat of blood.

Description

The Chinese medicine composition and its preparation method of a kind of reducing blood lipid
Technical field
The present invention relates to a kind of Chinese medicine composition of reducing blood lipid and its preparation method, belong to technical field of traditional Chinese medicines.
Background technology
With the continuous development of China's economy the living standard of the people gradually steps up, diet and life style are also opened Begin to develop to diversification direction, in recent years, China human mortality blood lipid level shows the trend risen year by year, hyperlipemic patients also with Be significantly increased.Especially in elderly population, high fat of blood is even more to become common disease and frequently-occurring disease, and serious threat people's Health.
Hyperlipemia is a kind of common and multiple metabolic disease, be cause the significant risk of cardiovascular and cerebrovascular disease because Element.Name of disease without hyperlipemia in traditional Chinese medicine, it is believed that hyperlipemia is asthenia in origin and asthenia in superficiality, and category " blood stasis ", " phlegm is turbid " category, clinic are distinguished Card is attributed to that caused by liver and kidney deficiency, insufficiency of the spleen phlegm is turbid, qi depression to blood stasis, during treatment mostly using tonify the liver and kidney, strengthening the spleen and replenishing qi, nourishing yin and nourishing blood, Promoting blood circulation and removing blood stasis, clearing away heat and loosing the bowels, the medicine to eliminate indigestion and phlegm.
Often there are Lovastatin, Atorvastatin etc., but these medicines with oral drugs for the patient of hyperlipemia at present Long-term use can produce certain drug resistance, cause its therapeutic effect bad.If long-term use of such medicine, can also just produce compared with The internal organs such as big toxic side effect, infringement liver kidney.However, treatment and prevention of the traditional Chinese medicine to such disease have it is huge excellent Gesture.
The content of the invention
Present invention aims at a kind of Chinese medicine composition and its preparation method of reducing blood lipid is provided, the Chinese medicine composition is for clinic Hyperlipemic patients, have it is evident in efficacy, toxic side effect is small, and production Technology simple possible, production cost is low, the patient side of taking Just the advantages of.
The Chinese medicine composition of reducing blood lipid of the present invention, the raw material that it includes following weight proportion form:The red sage root 140~ 160 parts, 140~160 parts of turmeric, 140~160 parts of Fructus Aurantii, 140~160 parts of reticulate millettia, 90~110 parts of the Radix Astragali, ilex pubescens 90~ 110 parts, 80~100 parts of rhizoma Gastrodiae, 80~100 parts of rheum officinale, 80~100 parts of luffa, 80~100 parts of cassia twig, 50~70 parts of stiff silkworm, 50~70 parts of scorpio.
The specific raw material prescription of the Chinese medicine composition matches:150 parts of the red sage root, 150 parts of turmeric, 150 parts of Fructus Aurantii, reticulate millettia 150 parts, it is 100 parts of the Radix Astragali, 100 parts of ilex pubescens, 90 parts of rhizoma Gastrodiae, 90 parts of rheum officinale, 90 parts of luffa, 90 parts of cassia twig, 60 parts of stiff silkworm, complete 60 parts of scorpion.
The prescription of the Chinese medicine composition matches:140~160 parts of the red sage root, 140~160 parts of turmeric, Fructus Aurantii 140~ 160 parts, 140~160 parts of reticulate millettia, 90~110 parts of the Radix Astragali, 90~110 parts of ilex pubescens, 80~100 parts of rhizoma Gastrodiae, rheum officinale 80~ 100 parts, 80~100 parts of luffa, 80~100 parts of cassia twig, 50~70 parts of stiff silkworm, 50~70 parts of scorpio, 50~70 parts of lycopodium calvatum, 50~70 parts of Radix Angelicae Sinensis, 50~70 parts of caulis trachelospermi, 50~70 parts of wilsonii, 50~70 parts of grass-leaved sweetflag, 50~70 parts of rhizoma alismatis, Ramulus Taxilli 50~70 parts.
Prescription as Chinese medicine composition of the present invention, which matches, is preferably:150 parts of the red sage root, 150 parts of turmeric, 150 parts of Fructus Aurantii, chicken 150 parts of blood rattan, 100 parts of the Radix Astragali, 100 parts of ilex pubescens, 90 parts of rhizoma Gastrodiae, 90 parts of rheum officinale, 90 parts of luffa, 90 parts of cassia twig, stiff silkworm 60 Part, 60 parts of scorpio, 60 parts of lycopodium calvatum, 60 parts of Radix Angelicae Sinensis, 60 parts of caulis trachelospermi, 60 parts of wilsonii, 60 parts of grass-leaved sweetflag, 60 parts of rhizoma alismatis, mulberry It is parasitic 60 parts.
The preparation method of Chinese medicine composition of the present invention is as follows:Above-mentioned medicinal material is taken, is dried using vacuum microwave drying method, Drying temperature is 60~70 DEG C, and drying time is 0.5-2 hours, and equal into 100~300 mesh fine powders, mixing using ultramicro grinding After even, add the auxiliary material commonly used in pharmacy and various different oral formulations are made, produce.
Clinically prolonged application treats hyperlipemia to we, obtains the effect of good.The red sage root in side, property is bitter, is slightly cold, and is apt to The current blood vessels of energy, analgesic of becoming silted up of dispelling, and silt life of dispelling are newly without hindering just, to nurse one's health medicine first of blood system.Turmeric, can blood-breaking, stimulate the menstrual flow Analgesic, use is engaged with the red sage root, strengthens the work(of prescription promoting qi circulation and relieving pain;Being equipped with Fructus Aurantii can soothing the liver promoting the circulation of qi.The medicine of the above three is monarch drug in a prescription altogether. Reticulate millettia, bitter warm but not dry, temperature is longer than promoting circulation of blood and dissipates the stasis of blood, relaxing tendons and activating collaterals, and the simultaneous work(enriched blood, be equipped with the Radix Astragali, power is obligate without strong Walk, reinforce vital energy, make the prosperous then blood of gas.It is aided with ilex pubescens again, rheum officinale, aids in monarch drug in a prescription blood circulation and channel invigorating;It is subject to rhizoma Gastrodiae relieving convulsion and spasm, Intermittent headache, the strong convulsion of four limbs can be controlled, language has some setbacks;Luffa, it is sweet, put down.Dredging collateral, promoting blood circulation, wind-dispelling.It is logical to be subject to cassia twig temperature, enters ying blood, leads to Blood vessels, all medicines can be made up in the heart, brain.Coordinate stiff silkworm, scorpio, dredging the channel and relieve pain.Above-mentioned all medicines are ministerial drug altogether;It is aided with again Lycopodium calvatum, caulis trachelospermi, can pass through channels and collaterals, relieving convulsion and spasm.Radix Angelicae Sinensis can replenishing and activating blood, bowl spares has, is the panacea in blood.Stone Chang Pu, pungent-warm, can have one's ideas straightened out slit phlegm, restoring normal coordination between heart and kidney, and phlegm key is opened;Rhizoma alismatis, excreting dampness are purged heat, and heat conduction is gone from water channel.Finally, it is equipped with mulberry Parasitism, it can tonify the liver and kidney, to effect a permanent cure.Above-mentioned all medicines are adjuvant altogether, complete square all medicines share, may be such that and be of one blood, mechanism of qi is adjusted Freely, all disease self-healing.Promoting qi circulation and relieving pain, disperse blood stasis and dredge collateral, benefiting qi and nourishing blood, the work(of dissipating phlegm for resuscitation are played altogether in full side.The characteristics of our compatibility, place Side promoting blood circulation in be equipped with promoting the circulation of qi, can blood stasis removing analgesic, the stagnation of the circulation of vital energy can be solved again;Dissolving stasis is taken into account with enriching blood, up to the work(treated both principal and secondary aspect of disease.And rise To the purpose for the treatment of hypercalcinuria.
The preparation method of Chinese medicine composition of the present invention is:It is prepared by following steps method:
Above-mentioned medicinal material is taken, is dried using vacuum microwave drying method, drying temperature is 60~70 DEG C, and drying time is 0.5-2 hours, and the auxiliary material system commonly used in pharmacy after being well mixed, is added into 80~120 mesh fine powders using Ordinary pulverization Into various different oral formulations, produce.
Preferably, the preparation method of Chinese medicine composition of the present invention is:It is prepared by following steps method:
Above-mentioned medicinal material is taken, is dried using vacuum microwave drying method, drying temperature is 65 DEG C, and drying time is 1 hour, And after being well mixed, add the auxiliary material commonly used in pharmacy into 100 mesh fine powders using Ordinary pulverization and various differences are made orally Preparation, produce.
In order to illustrate the overall beneficial effect of reducing blood lipid technical scheme of the present invention, We conducted the contrast of a series of pharmacy Research, particular content are:
1 group of trial drug:Take red sage root 150g, turmeric 150g, Fructus Aurantii 150g, reticulate millettia 150g, Radix Astragali 100g, ilex pubescens 100g, rhizoma Gastrodiae 90g, rheum officinale 90g, luffa 90g, cassia twig 90g, stiff silkworm 60g, scorpio 60g, carried out using vacuum microwave drying method Dry, drying temperature is 65 DEG C, and drying time is 1 hour, and after being well mixed, then is added into 100 mesh fine powders using Ordinary pulverization Enter the starch commonly used in pharmacy and capsule is made, produce.
2 groups of trial drug:Take red sage root 150g, turmeric 150g, Fructus Aurantii 150g, reticulate millettia 150g, Radix Astragali 100g, ilex pubescens 100g, rhizoma Gastrodiae 90g, rheum officinale 90g, luffa 90g, cassia twig 90g, stiff silkworm 60g, scorpio 60g, lycopodium calvatum 60g, Radix Angelicae Sinensis 60g, trachelospermum jasminoide Rattan 60g, wilsonii 60g, grass-leaved sweetflag 60g, rhizoma alismatis 60g, Ramulus Taxilli 60g, are dried using vacuum microwave drying method, dry temperature Spend for 65 DEG C, drying time is 1 hour, and after being well mixed, is added using Ordinary pulverization into 100 mesh fine powders in pharmacy Capsule is made in conventional starch, produces.
Effective component of chinese medicine assay method of the present invention is as follows:
(1), water-soluble extractives determination method:The Chinese medicine mixed-powder about 3g of 1 group and 2 groups of Experimental agents of the present invention is taken, it is weighed Weight is put in 250ml conical flask, and precision adds water 100ml, shakes up and stoppers, weighed weight, after standing 1 hour, connection backflow Condenser pipe, it is heated to seething with excitement, and keeps micro-boiling 1 hour, after letting cool, removes conical flask, close plug, weighed weight, supplied and subtracted with water The weight of mistake, shakes up, and is filtered with filter is dried, and precision measures filtrate 25ml, puts and dries into the evaporating dish of constant weight, in water-bath On be evaporated after, after 105 DEG C are dried 3 hours, in dislocation drier, cool down 30 minutes, rapid accurately weighed weight, except as otherwise rule It is fixed outer, the percentage of water-soluble extractives in Chinese medicine composition of the present invention is calculated with dry product.
(2), ethanol soluble extractives determination method:According to said determination method, (1) water-soluble extractives determination method determines, with the respectively product Provide that 50% ethanol instead of water is solvent under kind of item.
The Chinese medicine composition water solubility extract content of the present invention of table 1
Compared with 1 group of trial drug:P<0.05,▲▲P<0.01。
(3), active constituent content measuring in Chinese medicine composition of the present invention
Using efficient liquid phase color method, with Agilent ZORBAX Ec lipse XDB-C18(4.6mm × 150mm, 5 μm), With methanol-water (15: 5) for mobile phase, flow velocity 1mL/min, Detection wavelength 270nm, to tanshinone in Chinese medicine composition of the present invention II A content is measured;It is ultraviolet using determined by ultraviolet spectrophotometry wavelength using vanilla root rot as color development system Spectrophotometry wavelength is 560nm, determines total saponin content.
The Chinese medicine composition active constituent content of the present invention of table 2
From the measurement result of table 2, it is 0.217mg/g that the present invention, which tests 1 group of medicine and contains tanshinone IIA, total saponin content 0.256mg/g, and the present invention tests 2 groups of medicine that to contain tanshinone IIA be 0.203mg/g, total saponin content 0.489mg/g.
The beneficial effect of Chinese medicine composition of the present invention:
Chinese medicine composition of the present invention is using traditional Chinese medical theory as guidance, and prescription choosing side is reasonable, and all medicine phases are matched somebody with somebody so that prescription has Promoting qi circulation and relieving pain, disperse blood stasis and dredge collateral, benefiting qi and nourishing blood, the work(of dissipating phlegm for resuscitation.Active ingredient (tanshinone IIA in Chinese medicine composition of the present invention And total saponin content) clearly, wherein tanshinone IIA modern pharmacology proves that it has function of promoting blood circulation to disperse blood clots, so as to be the present invention Inherent quality, which improves, provides experimental basis.And process for producing science simple possible of the present invention, production cost is relatively low, has production The advantage of the big production of industryization.Verified through clinical trial, the total effective rate of Chinese medicine composition of the present invention is up to 91.8%.
The selected medicinal material of reducing blood lipid prescription of the present invention, source, meridian distribution of property and flavor, major function are as follows:
The red sage root, it is labiate red sage root Salvia miltiorrhiza Bge. root and rhizome.Meridian distribution of property and flavor, property are micro- It is cold, bitter.Thoughts of returning home warp, Liver Channel.Effect and effect, stasis-dispelling and pain-killing, promoting blood circulation dysmenorrhoea, relieving restlessness that clears away heart-fire.With control irregular menstruation, Amenorrhea pain Jing, lumps in the chest and abdomen, chest and abdomen shouting pain, hot numbness pain, sore swollen toxin, dysphoria and insomnia;Hepatosplenomegaly, angina pectoris.
Turmeric, it is zingiberaceous plant turmeric Curcuma longaL. rhizome.Meridian distribution of property and flavor, it is warm-natured, it is bitter, pungent.Returns spleen Through, Liver Channel.Effect and effect, it is blood-breaking, inducing meastruation to relieve menalgia.With controlling trusted subordinate feeling of fullness distending pain, Disorder lumps in the abdomen, women's blood stasis, postpartum The stasis of blood stops stomachache, traumatic injury, carbuncle swells etc..
Fructus Aurantii is rutaceae bitter orange Citrus aurantium L. close to mellow fruit.Meridian distribution of property and flavor, it is warm-natured, It is bitter, pungent, sour.Returns spleen warp, stomach.Effect and effect, regulating the flow of QI to ease the stomach, the stagnant dissipate-swelling of row.With control the chest side of body stagnation of the circulation of vital energy, turgor labor pain, food Product is not changed, stopped in phlegm and retained fluid, gastroptosis, the prolapse of uterus, prolapse of the anus etc..
Reticulate millettia, it is legume spatholobus suberectus Spatholobus suberects Dunn. rattan.Meridian distribution of property and flavor, property Temperature, it is bitter, sweet.Return liver warp, kidney channel.Effect and effect, enrich blood, invigorate blood circulation, dredging collateral.With controlling irregular menstruation, blood deficiency chlorosis, numb paralysis Paralysis, arthralgia pain due to rheumatism.
The Radix Astragali, legume astragalus mongolicus Astragalus membranaceus Bge.var.mongholicus (Bge.) Hsiao and Astragalus membranacus A.membranaceus (Fisch.) Bge. root.Meridian distribution of property and flavor, slightly warm in nature are sweet.Returns spleen Through, lung channel.Effect and effect, invigorating qi for strengthening superficies, diuresis, pus draining and toxin expelling, myogenic.Treat shortness of breath palpitations, weak, collapse, spontaneous perspiration, robber Sweat, physically weak edema, chronic nephritis, chronic diarrhea, prolapse of the anus, the prolapse of uterus, ulcer is difficult to burst, the long disunion of the open sore part, children's bronchus asthma, Chronic hepatitis B, chronic nephritis and vital myocarditis.Use is preferably processed in tonifying Qi, and hidroschesis, diuresis, pus draining and toxin expelling myogenic preferably give birth to use.
Ilex pubescens, it is the root of holly plant ilex pubescens.Summer, Qiu Cai, section are dried.Nature and flavor,《Guangxi Chinese herbal medicine》Taste is micro- Bitter sweet, it is mild-natured, it is nontoxic.Major function, clearing heat and detoxicating, blood circulation and channel invigorating.Control anemopyretic cold, dyspnea and cough due to lung-heat, laryngeal edema, tonsillotome Inflammation, dysentery, coronary heart disease, the hemiplegia caused by cerebrovas-cularaccident,
Rhizoma Gastrodiae, it is orchid rhizoma Gastrodiae Gastrodia elata Bl. stem tuber.Meridian distribution of property and flavor, it is mild-natured, it is sweet.Return liver Through.Effect stops convulsion with effect, suppressing hyperactive liver for calming endogenous wind.With controlling dizziness of having a headache, extremity numbness, child convulsion, epilepsy clonus, lockjaw.
Rheum officinale, polygonum rheum palmatum Rheum palmatum, L., Rheum tanguticum Maxim Rheum tanguticum Maxim.ex Balf. or Rheum officinale Rheumoj-flcinale Baill. dry root and rhizome.Meridian distribution of property and flavor, it is cold in nature, Bitter.Returns spleen warp, stomach, large intestine channel, Liver Channel, pericardium channel.Effect and effect, purgating heat and bowels, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow.With Control not well real heat constipation, stagnant stomachache, rush down dysentery, jaundice with damp-heat pathogen, blood-head tells nosebleed, hot eyes, pharynx swelling, acute appendicitis furunculosis, blood stasis closed, fall Play damage.Suitable amount used externally, control scald, UGB.
Luffa, it is the vascular bundle of cucurbitaceous plant sponge gourd Luffa cylindrica (L.) Roem. ripening fruits.Property Taste channel tropism, it is mild-natured, it is sweet.Return lung warp, stomach, Liver Channel.Effect and effect, promoting blood circulation, dredging collateral, wind-dispelling.Caused with a variety of causes is controlled Stagnation of QI-blood, the obstructed pain in chest and hypochondrium of train of thought, stomachache, pain in the back, testicular pain, married woman's dysmenorrhoea, alactation etc.;Lung heat cough Cough, hemorrhoid complicated by anal fistula, uterine bleeding etc..
Cassia twig, it is canella Chinese cassia tree Cinnamomum cassia Presl dry bark.Meridian distribution of property and flavor, extremely hot in nature, It is acrid flavour, sweet.Return kidney channel, the spleen channel, the heart channel of Hang-Shaoyin, Liver Channel.Effect and effect, mends fire supporing yang, guiding fire to origin, eliminating cold to stop pain, warming meridian. For impotence Gong Leng, waist and knee crymodynia, deficiency of the kidney and dyspnea, deficient yang with upper manifestation, dizziness hot eyes, trusted subordinate's crymodynia, cold of insufficiency type vomiting and diarrhea, cold hernia stomachache, Dysmenorrhoea Amenorrhea.
The white stiff Beauveriabasiana of larva infection that stiff silkworm is Bombycidae insect bombyx mori Bombyx moriL. (Bals.) drying polypide lethal Vaillant.Meridian distribution of property and flavor, mild-natured, taste is salty, pungent.Return liver warp, lung channel, stomach.Effect is with making With dispelling wind and relieving convulsion, reducing phlegm and resolving masses.With controlling, convulsion, abscess of throat, pruitus, submandibular lymph nodes be scorching, facioplegia.
Scorpio, it is Buthidae animal buthus martensii Karscs Buthus martensii Karsch entirety.Meridian distribution of property and flavor, it is mild-natured, Acrid flavour.Return liver warp.Effect and effect, ceases wind antispastic, dispersing pathogen accumulation, remove obstruction in channels to relieve pain.For child convulsion, twitch spasm, apoplexy Mouth is askew, hemiplegia, lockjaw, rheumatoid arthritis stubborn, migraine and general headache, sore, scrofula.
Lycopodium calvatum, lycopsid lycopod Lycopodium clavatum L. whole herb with root.Meridian distribution of property and flavor, it is warm-natured, It is mildly bitter flavor, pungent.Return liver warp, the spleen channel, kidney channel.Effect and effect, cold-dispelling, dehumidification swelling, relaxing tendons and activating collaterals.For wind-cold-dampness arthralgia, Joint pain, numbness of skin, tetraparesis, oedema, traumatic injury.
Radix Angelicae Sinensis, umbelliferae angelica Angelica sinensis (Oliv.) Diels. root.Meridian distribution of property and flavor, it is warm-natured, It is sweet, pungent.Return liver warp, the heart channel of Hang-Shaoyin, the spleen channel.Effect and effect, replenishing and activating blood, menstruction regulating and pain relieving, relax bowel.With control blood deficiency chlorosis, Dizziness palpitaition, irregular menstruation, closed dysmenorrhea, asthenia cold abdominalgia, dry constipation of intestines, arthralgia pain due to rheumatism, injury from falling down, ulcer sores.
Caulis trachelospermi, it is the dry of apocynaceae plant trachelospermum jasminoide Trachelospermum jasminoides (Lindl.) Lem. Dry leaf bine stem.Meridian distribution of property and flavor, bitter, cold nature.Thoughts of returning home warp, Liver Channel, kidney channel.Effect and effect, dispelling wind and removing obstruction in the meridians, cool blood disappear It is swollen.With controlling beriberoid pyretic arthralgia, muscle arteries and veins contraction, soreness of waist and knee joint, larynx numbness, injury from falling down.
Wilsonii, Araliaceae wilsonii Acanthopanax senticosus (Rupr.et Maxim.) Harms's Root and root skin.Nature,taste and action, warm-natured, acrid flavour, slight bitter.Returns spleen warp, kidney channel, the heart channel of Hang-Shaoyin.Effect and effect, replenish qi to invigorate the spleen, kidney tonifying peace God.Treat the insufficiency of both the spleen and the kindey, soreness and weakness of waist and knees, physically weak weak, insomnia, dreaminess, poor appetite.
Grass-leaved sweetflag, acorus gramineus araceae plant Acorus tatarionwii Schott. rhizome.Meridian distribution of property and flavor, property Tepor, acrid flavour, hardship.Thoughts of returning home warp, stomach.Effect with effect, have one's ideas straightened out, slit phlegm, qi-regulating, promoting blood circulation, dissipate wind, dry.With controlling epilepsy, phlegm Faint, pyreticosis coma, forgetful, deafness with qi stagnation, ambition unhappiness, stomachache, stomachache, wind-cold-dampness arthralgia, swollen ulcer drug, traumatic injury etc..
Rhizoma alismatis, Notes On Alism At Aceae rhizoma alismatis Alisma plantago-aquatica L.var.orientalis (Sam.) Juzep. stem tuber.Meridian distribution of property and flavor, it is cold in nature, it is sweet, light.Return kidney channel, bladder warp.Effect and effect, diuresis, clearing away damp-heat.With Control difficult urination, oedema turgor, vomiting, rush down dysentery, phlegm and retained fluid, tinea pedis, gonorrhoea, hematuria etc..
Ramulus Taxilli, Loranthaceae plant Ramulus Taxilli Taxillus chinensis (DC.) Danser. stem and branch with leaf.Property Taste channel tropism, it is bitter, sweet, it is mild-natured.Return liver warp, kidney channel.Effect and effect, filling liver kidney, strengthening the bones and muscles, wind-damp dispelling, antiabortive member.With controlling wind Arthritis with fixed pain caused by dampness pain, soreness and weakness of waist and knees, muscles and bones is powerless, uterine bleeding warp is more, blood leaking in gestation, fetal irritability, hypertension.
Embodiment
It is the specific embodiment of present invention below, is solved the skill of technical problem in present specification for illustrating Art scheme, contribute to skilled artisan understands that present invention, but the realization of technical solution of the present invention is not limited to these Embodiment.
Embodiment 1
Take red sage root 150g, turmeric 150g, Fructus Aurantii 150g, reticulate millettia 150g, Radix Astragali 100g, ilex pubescens 100g, rhizoma Gastrodiae 90g, Rheum officinale 90g, luffa 90g, cassia twig 90g, stiff silkworm 60g, scorpio 60g, are dried, drying temperature using vacuum microwave drying method For 65 DEG C, drying time is 1 hour, and after being well mixed, is added using Ordinary pulverization into 100 mesh fine powders in pharmacy often Capsule is made in starch, produces.
Embodiment 2
Take red sage root 150g, turmeric 150g, Fructus Aurantii 150g, reticulate millettia 150g, Radix Astragali 100g, ilex pubescens 100g, rhizoma Gastrodiae 90g, Rheum officinale 90g, luffa 90g, cassia twig 90g, stiff silkworm 60g, scorpio 60g, lycopodium calvatum 60g, Radix Angelicae Sinensis 60g, caulis trachelospermi 60g, wilsonii 60g, grass-leaved sweetflag 60g, rhizoma alismatis 60g, Ramulus Taxilli 60g, are dried using vacuum microwave drying method, and drying temperature is 65 DEG C, is done The dry time is 1 hour, and after being well mixed, adds the starch system commonly used in pharmacy into 100 mesh fine powders using Ordinary pulverization Into capsule, produce.
Embodiment 3
Take red sage root 160g, turmeric 140g, Fructus Aurantii 140g, reticulate millettia 160g, Radix Astragali 90g, ilex pubescens 110g, rhizoma Gastrodiae 100g, Rheum officinale 100g, luffa 80g, cassia twig 100g, stiff silkworm 70g, scorpio 50g, are dried using vacuum microwave drying method, dry temperature Spend for 70 DEG C, drying time is 0.5 hour, and after being well mixed, adds pharmacy into 120 mesh fine powders using Ordinary pulverization Various different oral formulations are made in upper conventional auxiliary material, produce.
Embodiment 4
Take red sage root 140g, turmeric 160g, Fructus Aurantii 160g, reticulate millettia 140g, Radix Astragali 110g, ilex pubescens 90g, rhizoma Gastrodiae 80g, big Yellow 80g, luffa 100g, cassia twig 80g, stiff silkworm 50g, scorpio 70g, are dried, drying temperature using vacuum microwave drying method For 60 DEG C, drying time is 2 hours, and after being well mixed, is added in pharmacy and commonly used into 80 mesh fine powders using Ordinary pulverization Auxiliary material various different oral formulations are made, produce.
Embodiment 5
Take red sage root 160g, turmeric 140g, Fructus Aurantii 160g, reticulate millettia 160g, Radix Astragali 110g, ilex pubescens 90g, rhizoma Gastrodiae 80g, big Yellow 100g, luffa 80g, cassia twig 100g, stiff silkworm 50g, scorpio 50g, lycopodium calvatum 70g, Radix Angelicae Sinensis 70g, caulis trachelospermi 50g, wilsonii 50g, grass-leaved sweetflag 70g, rhizoma alismatis 70g, Ramulus Taxilli 50g, are dried using vacuum microwave drying method, and drying temperature is 65 DEG C, is done The dry time is 1 hour, and after being well mixed, adds the auxiliary material system commonly used in pharmacy into 100 mesh fine powders using Ordinary pulverization Into various different oral formulations, produce.
Embodiment 6
Take red sage root 140g, turmeric 160g, Fructus Aurantii 140g, reticulate millettia 140g, Radix Astragali 90g, ilex pubescens 110g, rhizoma Gastrodiae 100g, Rheum officinale 80g, luffa 100g, cassia twig 80g, stiff silkworm 70g, scorpio 70g, lycopodium calvatum 50g, Radix Angelicae Sinensis 50g, caulis trachelospermi 70g, wilsonii 50g, grass-leaved sweetflag 50g, rhizoma alismatis 50g, Ramulus Taxilli 70g, are dried using vacuum microwave drying method, and drying temperature is 65 DEG C, is done The dry time is 1 hour, and after being well mixed, adds the auxiliary material system commonly used in pharmacy into 120 mesh fine powders using Ordinary pulverization Into various different oral formulations, produce.
In order to further verify the clinical efficacy of blood fat reducing preparation of the present invention, we are by above-mentioned specific embodiment 1-2 The medicine of preparation has carried out corresponding clinical test, is now reported as follows result.
2nd, clinical observation and curative effect
2.1st, research object:
Case selection:Standard according to《New Chinese medicine treats the clinical guidance principle of hyperlipidemia》Specified diagnostic criteria is: Serum total cholesterol (TC)>5.32mmol/L, triglycerides (TG) >=1.7mmoL/L, or HDL-C (HDL- C):Man<1.04mmol/L female<1.17mmol/L.All cases are the invalid patient of diet control, and patient clinical shows more For dizziness, the disease such as limb is heavy, uncomfortable in chest, headache, palpitaition, shortness of breath, pulse condition string is sliding or string is common, rare intermittent pulse;Tongue nature is with dark red, purple Dark common, corpulent tongue, tongue fur are common with greasy tongue.Chinese medical discrimination is common with blood stasis and intermingled phlegm and blood stasis type.
2.2nd, research method
(1) general information:The hyperlipidemia patient 119 for meeting above-mentioned case standard is collected, is divided into two groups, treats 1 group 58 Example, man 31, female 27;It is 45~69 years old age, average 54.3 ± 1.4 years old;The course of disease 2~6 years, average course of disease 4.3 ± 0.5 years, 2 groups 61 are treated, male 33, female 28;It is 43~66 years old age, average 52.7 ± 1.6 years old;The course of disease 2~7 years, average course of disease 4.6 ± 0.7 year, age, sex between two groups of patients, course of disease no significant difference, there is comparativity.
(2) medicine group:
Medicine group of the present invention:Respectively according to the raw material proportioning and preparation method as described in above-mentioned 1 group, 2 groups of embodiment, system For into capsule, produce.
2.3rd, treatment method and curative effect
(1) treatment method:
Test 1 group give prepare 1 group of embodiment capsule, experiment 2 groups give prepare 2 groups of embodiment capsules, daily 3 It is secondary, divide early, middle and late each 1 time and warmly take, 3 tablets each time/time, after even served 3 months;Diagnostic Value of Fasting Serum T-CHOL is determined before medication (TC), every blood such as triglycerides (TG), LDL-C (LDL-C), HDL-C (HDL-C) Fat indicators, the 1st day blood drawing check Diagnostic Value of Fasting Serum items blood lipids index on an empty stomach after treatment end.
(2) criterion of therapeutical effect:Reference《New Chinese medicine treats the guideline of clinical investigations of hyperlipidemia》, it is effective:Blood fat is every Index reaches following any one person, and TC declines >=20% or TG and declines >=40%, or HDL-C rises 0.25mmol/L;Effectively: Lipid examination reaches following any one person, TC decline 10%~20% or decline 20%~40% or LDL-C decline 10%~ 20% or HDL-C rises 0.1~0.26mmol/L;It is invalid:Not up to above-mentioned standard.
(3) statistical analysis:Contrast is using t inspections and X between each group2Examine.
Experimental result:
The comparison of 3 two groups of patients with lipid's index levels of table
Note:Before and after treatment relatively,▲▲P<0.01,P<0.05。
As can be seen from Table 3, after patient takes blood lipid-lowering medicine of the present invention, patient's fasting blood of 1 group and 2 groups of experiment T-CHOL (TC), the numerical value of triglycerides (TG) decline obvious in clear, have statistical significance (P<0.05), but experiment 1 group With LDL-C (LDL-C) LDL-C HDL-C (HDL-C) content liter in 2 groups of patients serums Height, but without equal no difference of science of statistics.The effect of wherein testing 2 groups is optimal.The description of test, prompt Chinese medicine composition pair of the present invention Hypercalcinuria patient has preferable therapeutic action.
4 two groups of clinical therapeutic efficacies of table compare
Note:1 group is tested to compare,▲▲P<0.01,P<0.05。
As can be known from Table 4,1 group of present invention experiment and 2 groups of total effective rates are respectively 63.8%, 91.8%, above-mentioned clinic As shown by data, Chinese medicine composition of the present invention have significant therapeutic effect in clinical practice, and for hyperlipemic patients, medicine makes During, do not find to there is any toxic side effect.
In summary, the preparation technology of Chinese medicine composition of the present invention is simple, feasible, suitable for the big production of technology, has very Good application prospect.

Claims (4)

1. a kind of Chinese medicine composition of reducing blood lipid, it is characterised in that the bulk drug that it includes following weight proportion forms:The red sage root 140~160 parts, 140~160 parts of turmeric, 140~160 parts of Fructus Aurantii, 140~160 parts of reticulate millettia, 90~110 parts of the Radix Astragali, Mao Dong Blue or green 90~110 parts, 80~100 parts of rhizoma Gastrodiae, 80~100 parts of rheum officinale, 80~100 parts of luffa, 80~100 parts of cassia twig, stiff silkworm 50 ~70 parts, 50~70 parts of scorpio.
2. Chinese medicine composition as claimed in claim 1, it is characterised in that the bulk drug composition that it includes following weight proportion is excellent Elect as:150 parts of the red sage root, 150 parts of turmeric, 150 parts of Fructus Aurantii, 150 parts of reticulate millettia, 100 parts of the Radix Astragali, 100 parts of ilex pubescens, rhizoma Gastrodiae 90 Part, 90 parts of rheum officinale, 90 parts of luffa, 90 parts of cassia twig, 60 parts of stiff silkworm, 60 parts of scorpio.
3. Chinese medicine composition as claimed in claim 1 or 2, the preparation method step of the Chinese medicine composition is as follows:Take above-mentioned Medicinal material, it is dried using vacuum microwave drying method, drying temperature is 60~70 DEG C, and drying time is 0.5-2 hours, and is used Ordinary pulverization after being well mixed, adds the auxiliary material commonly used in pharmacy and various differences is made orally into 80~120 (mesh) fine powders Preparation, produce.
4. Chinese medicine composition as claimed in claim 1 is preparing the application in treating hyperlipidaemic conditions medicine.
CN201711290203.9A 2017-12-08 2017-12-08 The Chinese medicine composition and its preparation method of a kind of reducing blood lipid Pending CN107753879A (en)

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CN102356985A (en) * 2011-10-27 2012-02-22 温民 Medicinal pillow with effect of regulating blood fat
CN103655641A (en) * 2013-12-10 2014-03-26 深圳市仁泰生物科技有限公司 Antrodia camphorata extraction method, antrodia camphorata oral liquid and preparation method of antrodia camphorata oral liquid
CN103876218A (en) * 2013-12-06 2014-06-25 珍熙(福建)生物科技有限公司 Anoectochilus formosanus extracting solution and preparation method thereof as well as anoectochilus formosanus drinks and preparations method thereof
CN104127797A (en) * 2014-08-22 2014-11-05 刘兆艳 Traditional Chinese medicine preparation for treating aphasia after craniocerebral trauma and preparation method thereof
CN104667181A (en) * 2015-02-10 2015-06-03 青岛市中心医院 Traditional Chinese medicine for treating sequela of deep venous thrombosis
CN105920375A (en) * 2016-07-06 2016-09-07 贾庭山 Traditional Chinese medicine for treating cardiovascular and cerebrovascular diseases and preparation method of traditional Chinese medicine
CN106177572A (en) * 2016-08-26 2016-12-07 于波 A kind of Chinese medicine decoction treating aplastic anemia
CN106729432A (en) * 2017-01-19 2017-05-31 贾庭山 A kind of Chinese medicine composition for treating cardiovascular and cerebrovascular disease

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102356985A (en) * 2011-10-27 2012-02-22 温民 Medicinal pillow with effect of regulating blood fat
CN103876218A (en) * 2013-12-06 2014-06-25 珍熙(福建)生物科技有限公司 Anoectochilus formosanus extracting solution and preparation method thereof as well as anoectochilus formosanus drinks and preparations method thereof
CN103655641A (en) * 2013-12-10 2014-03-26 深圳市仁泰生物科技有限公司 Antrodia camphorata extraction method, antrodia camphorata oral liquid and preparation method of antrodia camphorata oral liquid
CN104127797A (en) * 2014-08-22 2014-11-05 刘兆艳 Traditional Chinese medicine preparation for treating aphasia after craniocerebral trauma and preparation method thereof
CN104667181A (en) * 2015-02-10 2015-06-03 青岛市中心医院 Traditional Chinese medicine for treating sequela of deep venous thrombosis
CN105920375A (en) * 2016-07-06 2016-09-07 贾庭山 Traditional Chinese medicine for treating cardiovascular and cerebrovascular diseases and preparation method of traditional Chinese medicine
CN106177572A (en) * 2016-08-26 2016-12-07 于波 A kind of Chinese medicine decoction treating aplastic anemia
CN106729432A (en) * 2017-01-19 2017-05-31 贾庭山 A kind of Chinese medicine composition for treating cardiovascular and cerebrovascular disease

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