CN104740407A - Traditional Chinese medicine preparation for treating pharyngitis and production method of traditional Chinese medicine preparation - Google Patents
Traditional Chinese medicine preparation for treating pharyngitis and production method of traditional Chinese medicine preparation Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating pharyngitis. The traditional Chinese medicine preparation is prepared from the following raw herbal materials in parts by weight: 15-20 parts of dwarf lilyturf tuber, 7-13 parts of pseudobulb of corymbose coelogyne, 15-25 parts of yerbadetajo herb, 10-15 parts of root of common aneurolepidium, 9-16 parts of common macrocarpium fruit, 12-16 parts of all-grass or root of delavay falsepanax, 10-14 parts of root of siebold primrose, 12-18 parts of herb of bigflower clinopodium, 11-16 parts of baikal skullcap root, 8-13 parts of natural indigo, 11-16 parts of entireleaf neoalsomitra, 8-13 parts of veronicastrum herb, 13-20 parts of root of straight ladybell, 9-14 parts of Indian trumetflower seed and 10-15 parts of wild chrysanthemum flower. The traditional Chinese medicine preparation has the advantages that the medical materials supplement one another to achieve the effects of clearing away heat and toxic materials, ventilating the breast and moistening the throat, and relieving sore throat and dispersing phlegm, and the traditional Chinese medicine preparation has a remarkable treatment effect on the pharyngitis caused by various reasons; the traditional Chinese medicine preparation is developed on the basis of the traditional syndrome differentiation and treatment of the traditional Chinese medicine in combination with the modern latest scientific achievements; various medical materials are combined; the traditional Chinese medicine preparation has the characteristics of remarkable curative effect, safety and convenience, and low cost.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine preparation for the treatment of pharyngitis and preparation method thereof.
Background technology
Pharyngitis can be divided into acute pharyngitis and chronic pharyngitis.Acute pharyngitis is the acute inflammation of pharyngeal mucosa and sub-mucosal tissues.Pharynx lymphoid tissue is often involved.Inflammation can be limited in early days, often can relate to whole pharyngeal cavity with disease progression, with autumn and winter and at the end of winter and the beginning of spring more common.Chronic pharyngitis is also known as chronic simple pharyngitis, more common.Pathological changes, mainly at mucous layer, shows as pharyngeal mucosa chronic congestion.Connective tissue proliferation under mucosa and mucosa.Mucous gland can be loose, and secretory function is hyperfunction, and mucilage secretion increases.Common adult, the course of disease is long, easily recurs.
Pharyngitis belongs to the traditional Chinese medical science " sore throat " category.Pharynx is the door of lung, straight-through extraneous, is subject to exopathogen, and its morbidity and lung, spleen, liver, kidney are closely related, and Holy Benevolent Prescriptions is thought: " ailment said due to cold or exposure steam, fights in spleen lung, then meridians blocking barrier profit, and pathogenic heat attack punching, and the part of the body cavity above the diaphragm housing the heart and lungs is stopped up stagnant, therefore order is had sore throat also." fiber crops day bright etc. think that pharyngitis is by " seven emotions pent-up, caused in the stagnant vapour lock larynx of expectorant ", with the card of the deficiency of YIN, the deficiency of vital energy, expectorant heat, therefore answer promoting QI to circulate and dispersing the agglomeration of the pathogens, lowering the adverse-rising QI and eliminating phlegm on treating.With the taste treatment of pinellia tuber and magnolia bark Tonga, evident in efficacy.For the record about throat in combination green for a long time " Plain Questions " and " General Treatise on the Cause and Symptoms of Diseases ", sum up the Therapeutic Principle of pharyngitis based on function of spleen and stomach regulating, clinically be divided into spleen and stomach damp-heat type, due to weakness of spleen and stomach and gastric heat YIN-deficiency type, add and subtract with Pingwei San respectively, SHENLING BAISHU SAN is added and subtracted, yunü decoction adds taste treatment, all obtains good effect.
Application publication number CN 103566169 A(application number 201310550839.8) Chinese invention patent document disclose a kind of Chinese medicine composition for the treatment of pharyngitis, be made up of the medical material of following parts by weight: Semen Sterculiae Lychnophorae 12-17 part, Flos Matricariae chamomillae 27-32 part, Radix Glycyrrhizae 12-17 part, Flos Jasmini Sambac 8-12 part, Flos Lonicerae 17-22 part, Cortex Magnoliae Officinalis 8-12 part, Radix Platycodonis 10-15 part, Fructus Arctii 10-15 part, Radix Scrophulariae 10-15 part, Herba Menthae 8-12 part, Indigo Naturalis 27-32 part, Poria 8-12 part, Radix Rehmanniae 10-15 part, Radix Ophiopogonis 10-15 part.Application publication number CN 103800696 A(application number 201410080472.2) Chinese invention patent document disclose a kind of Chinese medicine preparation for the treatment of pharyngitis, be made up of the raw material of Chinese medicine of following mass fraction: Fructus Arctii 10-12, Radix Glycyrrhizae 6-9, Cortex Magnoliae Officinalis 12-15, Fructus Xanthii 10-12, Herba Houttuyniae 15-20, Radix Rehmanniae 20-25, Rhizoma Et Radix Notopterygii 15-18, Bulbus Fritillariae Thunbergii 10-12, Radix Scrophulariae 20-25, Fructus Kochiae 10-12, Semen Oroxyli 6-9, Radix Saposhnikoviae 10-12, Fructus Jujubae 10-12, Pericarpium Citri Reticulatae 12-15, Radix Peucedani 12-15, Radix Ophiopogonis 10-12, Herba Dendrobii 10-12, Radix Trichosanthis 15-20, Rhizoma Cyperi 10-12, Flos Mume 2-3, Fructus Crataegi 10-12, Radix Angelicae Sinensis 10-12, Radix Salviae Miltiorrhizae 10-12, Lignum Dalbergiae Odoriferae 6-9, Rhizoma Cimicifugae 6-9, Fructus Aurantii 6-9, Rhizoma Belamcandae 6-9, Radix Stephaniae Tetrandrae 6-9, Flos Carthami 10-12 and Rhizoma Chuanxiong 10-12.Application publication number CN 104225335 A(application number 201410516607.5) Chinese invention patent document disclose a kind of Chinese medicine composition for the treatment of pharyngitis,: Flos Lonicerae 6g, Herba Taraxaci 6g, Fructus Gardeniae 4g, Radix Isatidis 8g, Folium Isatidis 6g, Radix Bupleuri 5g, Caulis Bambusae In Taenia 7g, Retinervus Luffae Fructus 7g, Bulbus Fritillariae Thunbergii 5g, Bulbus Fritillariae Cirrhosae 5g, Radix Ophiopogonis 8g, Poria 8g, Pericarpium Citri Reticulatae 8g, Radix Scutellariae 5g, Radix Glycyrrhizae 3g.
Current western medical treatment pharyngitis, based on methods such as antibacterial, antiviral, obtains certain curative effect clinically, but has also occurred series of problems, as bacterial resistance, dysbacteriosis, and patient's immunity reduction etc.Chinese traditional treatment pharyngitis, uses organic conception, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, the side's of sending medication, and can effectively relief of symptoms, raising cure rate, minimizing recur, advantage is remarkable.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare simple, taking convenience, the safely and effectively Chinese medicine preparation for the treatment of pharyngitis and preparation method thereof.This Chinese medicine preparation determined curative effect and having no side effect.
Technical scheme of the present invention is:
Treatment pharyngitis Chinese medicine preparation, be prepared from by following bulk drugs, be weight portion: Radix Ophiopogonis 15-20; Pseudobulbus Coelogynes corymbosae 7-13; Alternanthera sessilis (L.) DC. 15-25; Radix Aneurolepidii 10-15; Fructus Corni 9-16; Herba seu Radix Nothopanacis delavayi 12-16; Radix Primulae sieboldii 10-14; Herba Clinopodii megalanthi 12-18; Radix Scutellariae 11-16; Indigo Naturalis 8-13; Neoalsomitra integrifoliola (Cogn.) Hucth. 11-16; Herba Veronicastri 8-13; Radix Adenophorae (Radix Glehniae) 13-20; Semen Oroxyli 9-14; Flos Chrysanthemi Indici 10-15.
In preferred scheme, Radix Ophiopogonis 16-19; Pseudobulbus Coelogynes corymbosae 9-11; Alternanthera sessilis (L.) DC. 18-22; Radix Aneurolepidii 11-14; Fructus Corni 11-14; Herba seu Radix Nothopanacis delavayi 13-15; Radix Primulae sieboldii 11-13; Herba Clinopodii megalanthi 13-17; Radix Scutellariae 13-14; Indigo Naturalis 10-11; Neoalsomitra integrifoliola (Cogn.) Hucth. 13-14; Herba Veronicastri 9-12; Radix Adenophorae (Radix Glehniae) 15-18; Semen Oroxyli 11-12; Flos Chrysanthemi Indici 11-14.
Be more preferably, Radix Ophiopogonis 17.5; Pseudobulbus Coelogynes corymbosae 10; Alternanthera sessilis (L.) DC. 20; Radix Aneurolepidii 12.5; Fructus Corni 12.5; Herba seu Radix Nothopanacis delavayi 14; Radix Primulae sieboldii 12; Herba Clinopodii megalanthi 15; Radix Scutellariae 13.5; Indigo Naturalis 10.5; Neoalsomitra integrifoliola (Cogn.) Hucth. 13.5; Herba Veronicastri 10.5; Radix Adenophorae (Radix Glehniae) 16.5; Semen Oroxyli 11.5; Flos Chrysanthemi Indici 12.5.
The Chinese medicine preparation for the treatment of pharyngitis, it is characterized in that, be made into pharmaceutically acceptable decoction, preparation method is as follows:
(1) Fructus Corni is cleaned, and adds yellow wine and mixes thoroughly (Fructus Corni: yellow wine=5:1), stew to moisten, and puts suitable to steam in container, steams and exhausts to wine, take out dry, smash to pieces for subsequent use by Steam Heating; Semen Oroxyli and Indigo Naturalis are ground into fine powder respectively, for subsequent use;
(2) the raw material medicated powder mixing after step (1) being processed, sieves, is placed in penetrating bag, for subsequent use;
(3) Radix Ophiopogonis, Radix Aneurolepidii, Herba seu Radix Nothopanacis delavayi, Radix Primulae sieboldii, Radix Scutellariae, Neoalsomitra integrifoliola (Cogn.) Hucth., Radix Adenophorae (Radix Glehniae) and Flos Chrysanthemi Indici are together placed in Chinese medicine pan, the clear water adding 4-8 times amount soaks (clear water preferably adding 6 times amount soaks), then the penetrating bag of step (2) gained is added, intense fire is heated to boil, turn slow fire boiling twice, each each decoction 48-70 minute, merges twice decocting liquid, filter, obtain decocting liquid 1;
(4) Pseudobulbus Coelogynes corymbosae, Alternanthera sessilis (L.) DC., Herba Clinopodii megalanthi and Herba Veronicastri are added clear water and do not have powder, slow fire boiling twice, each respectively decoction 15-25 minute (preferably each each decoction 20 minutes), collecting decoction, filtration, obtains decocting liquid 2;
(5) by decocting liquid 1 and decocting liquid also 2-in-1, be evaporated to 1/2 of original volume, dry heat sterilization, cooling, encapsulation, to obtain final product.
The preparation method of the Chinese medicine decoction of above-mentioned treatment pharyngitis, preferred scheme is, the time of soaking in step (3) is 1.5-2.5 hour (the preferred time of soaking is 1.8-2.2 hour, and the time of the immersion be more preferably is 2.0 hours).
The preparation method of the Chinese medicine decoction of above-mentioned treatment pharyngitis, preferred scheme is, each respectively decoction 54-64 minute (preferably each each decoction 59 minutes) in step (3).
The preparation method of described pill is:
(1) Fructus Corni is cleaned, and adds yellow wine and mixes thoroughly (Fructus Corni: yellow wine=5:1), stew to moisten, and puts suitable to steam in container, steams and exhausts to wine, take out dry, smash to pieces for subsequent use by Steam Heating; Semen Oroxyli and Indigo Naturalis are ground into fine powder respectively, for subsequent use;
(2) get scutellaria tablet, put in pot, intense fire heats, and when frying to pitchy, spray clear water goes out most Mars, takes out, dries, smash to pieces for subsequent use;
(3) crude drug except Fructus Corni, Semen Oroxyli, Indigo Naturalis and Radix Scutellariae is placed in Chinese medicine extracting tank, add the ethanol (preferably adding the ethanol of 5 times amount) of 4-6 times amount, reflux, extract, twice, first time extracts 20-30 minute (preferably first time extracts 25 minutes), second time is extracted 12-18 minute (preferably second time is extracted 15 minutes), merge extractive liquid, filter, filtrate is for subsequent use;
(4) above-mentioned filtrate is concentrated into the clear paste that density is about 1.20g/mL, add the raw material medicated powder after step (1) and step (2) process, add sucrose fine while stirring, stir, be processed into the pill of Semen Glycines size, dry, encapsulation, to obtain final product.
The preparation method of the medicine pill of above-mentioned treatment pharyngitis, preferred scheme is, in step (3), the mass concentration of added ethanol is the mass concentration of the preferred added ethanol of 60%-80%(is 65%-75%, and the mass concentration of the added ethanol be more preferably is 70%).
The preparation method of described thick paste agent is:
(1) Semen Oroxyli is cleaned, and slow fire heats, and stir-fry limit, limit is spilled into saline solution (Semen Oroxyli: Sal=50:1), and frying extremely faint yellow is degree, takes out, smashs to pieces, for subsequent use; Get scutellaria tablet, fry with high heat to complete burnt, cool, smash to pieces, for subsequent use; Indigo Naturalis is ground into fine powder, for subsequent use;
(2) medical material after step (1) being processed, together Chinese medicine extracting tank is placed in surplus stock medicine, add the clear water (preferably adding the clear water of 10 times amount) of 8-12 times amount, big fire is heated to boil, and turns little fire and decocts three times, respectively decocts 20-28 minute (preferably each respectively decoction 24 minutes) at every turn, merge twice decocting liquid, filter, obtain filtrate, for subsequent use;
(3) during above-mentioned filtrate reduced in volume to 80 DEG C, relative density is the thick paste of 1.30-1.33, sterilizing, and encapsulation, to obtain final product.
The preparation method of described tablet is:
(1) various crude drug is taken by formula proportion, fully dry, grind into powder, cross 100-120 mesh sieve (preferred mistake 110 mesh sieve), obtain mixed powder;
(2) above-mentioned medicated powder is measured according to 0.3-0.5g/ sheet (preferably according to 0.4g/ sheet), make tablet dosage form according to the preparation for processing of tablet.
Chinese medicine preparation scientific formula provided by the invention, the preparation method of various dosage form is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1,medicine of the present invention supplements and complements each other, and has heat-clearing and toxic substances removing, the chest stuffiness relieving wets one's whistle, sore-throat relieving reduces phlegm effect, has significant therapeutic effect to the pharyngitis that a variety of causes causes;
2,medicine of the present invention, except the effect such as have antibacterial, antiviral, antiinflammatory, reduce phlegm, particularly has obvious therapeutic effect to pharyngeal mucosa hyperemia, edema, plumpness etc. in various degree;
3,the present invention develops in conjunction with latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment, and all medicines share, and has evident in efficacy, safe ready, cheap feature.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Ophiopogonis: source: this product is the dried root of liliaceous plant Radix Ophiopogonis (dwarf lilyturf).Character: this product is spindle, two ends are point slightly.Surface yellow-white or faint yellow, has thin longitudinal grin.Matter is pliable and tough, section yellow-white, and translucent, center pillar is tiny.Nature and flavor: sweet, micro-hardship, is slightly cold.Gui Jing: GUIXIN, lung, stomach warp.Function cures mainly: YIN nourishing and the production of body fluid promoting, and lung moistening clears away heart-fire.For dryness of the lung dry cough.Chronic consumptive disease is coughed, and Tianjin wound is thirsty, vexed insomnia, and interior-heat is quenched one's thirst, dryness of the intestine constipation; Pharyngeal diphtheria.
Pseudobulbus Coelogynes corymbosae: base is former: be pseudobulb or the herb of orchid umbrella room Pseudobulbus Coelogynes corymbosae.Nature and flavor: Xin Gan are cool.Function cures mainly: clearing and antitussive, hemostasis analgesic therapy, synthetism.Control bronchitis, flu, fracture, soft tissue contusion.
Alternanthera sessilis (L.) DC.: base is former: the herb of Amaranthaceae Alternanthera plant Alternanthera sessilis (L.) DC..Nature and flavor: micro-sweet, light, cool.Function cures mainly: clearing away heat and cooling blood, inducing diuresis and reducing edema, draws out pus by applying a plaster to the affected part antipruritic.For dysentery, epistaxis, spitting of blood, has blood in stool, urethritis, pharyngitis, mastitis, dysuria; Furuncle toxic swelling is controlled in external, eczema, dermatitis, tinea corporis, venom.
Radix Aneurolepidii: base is former: for grass relies the root of grass.Nature and flavor: sweet, cold.Function cures mainly: heat clearing away, hemostasis, diuresis.Cure cold, epistaxis, asthma.
Fructus Corni: base is former: this product is the drying and ripening sarcocarp of Fructus Corni English section plant Fructus Corni.Chemical analysis: containing morroniside, 7-0-methyl morroniside, sweroside, loganin, Fructus Corni tannin 1,2,3 etc.Nature and flavor: sour, puckery, tepor.Gui Jing: return liver, kidney channel.Effect: liver and kidney tonifying, essence astringing and desertion stemming.Cure mainly: for vertigo and tinnitus, soreness of waist and knee joint, sun is passed out semen repeatly, enuresis frequent micturition, bleeding not during menses, and profuse sweating is collapsed, and interior-heat is quenched one's thirst.
Herba seu Radix Nothopanacis delavayi: base is former: be Herb or the root of Araliaceae Nothopanax.Nature and flavor: sweetness and bitterness are cool.Function cures mainly: heat-clearing and toxic substances removing, regulating QI to relieve pain.Control throat burning pain, dyspepsia, menoxenia, traumatic injury, lumbago, skelalgia of rheumatism.
Radix Primulae sieboldii: base is former: the root and rhizome of heralding spring for Primulaceae Cui Nan.Nature and flavor: " Ningxia Chinese herbal medicine handbook ": " sweet, flat." function cures mainly: " Jilin Chinese herbal medicine ": " relieving cough and resolving phlegm.Control phlegm dyspnea cough.”
Herba Clinopodii megalanthi: base is former: be the herb of labiate Herba Clinopodii megalanthi.Nature and flavor: pungent micro-hardship are cool.Function cures mainly: heat clearing away suppressing the hyperactive liver.Control toothache.
Radix Scutellariae: base is former: this product is the dry root of labiate Radix Scutellariae.Character: this product conically.Surface brown color or buff, have sparse excipuliform radicula trace. and top is more coarse, and have the vertical wrinkle of distortion or irregular reticulate pattern, rift grain and scabriculous are arranged at bottom.Nature and flavor: bitter, cold.Gui Jing: return lung, gallbladder, spleen, large intestine, small intestine meridian.Effect: heat clearing and damp drying, rushes down people's removing toxic substances, hemostasis, antiabortive.Cure mainly: for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Indigo Naturalis: base is former: this product is acanthaceous vegetable acanthaceous indigo, the leaf of polygonaceae plant polygonum tinctorium ait. or cruciferae isatis or stem and leaf be through processing obtained dried powder or agglomerate.Character: this product is navy blue powder, body is light, easily flies upward; Or in irregular porous agglomerate, with hand rubbing twist with the fingers smalls.Nature and flavor: salty, cold.Gui Jing: return Liver Channel.Effect: heat-clearing and toxic substances removing, removing heat from blood, arresting convulsion.Cure mainly: for maculae caused by violent heat pathogen, heat in blood tells nosebleed, chest pain hemoptysis, aphtha, mumps, sore throat, pediatric epilepsy scared.
Neoalsomitra integrifoliola (Cogn.) Hucth.: base is former: be the tuber of cucurbitaceous plant Neoalsomitra integrifoliola (Cogn.) Hucth..Chemical analysis: containing Saponin and bitter principle.The glycoside unit mainly oleanolic acid of Saponin, sugar is glucose, glucuronic acid etc.Nature and flavor: " choosing of Simao, Yunnan Chinese herbal medicine ": " pained, cold." function cures mainly: " choosing of Simao, Yunnan Chinese herbal medicine ": " heat-clearing and toxic substances removing, anti-inflammation and sterilization, convergence pain relieving.Control bacillary dysentery, acute gastroenteritis, gastric and duodenal ulcers, abdominal pain, diarrhoea, urinary tract infection, high heat, pharyngolaryngitis, tonsillitis, has blood in stool, neurasthenia.”
Herba Veronicastri: base is former: be the herb of goatweed floating and thready pulse Herba veronicastri villosuli, veronicastrum latifoliumYamazaki or stenostachyous veronicastrum herb.Nature and flavor: bitter, cool.Function cures mainly: heat clearing away, row water, detumescence, removing toxic substances.Control cough due to lung-heat, edema, gonorrhea, conjunctival congestion, traumatic injury, scald.
Radix Adenophorae (Radix Glehniae): base is former: be campanulaceae Lady bell plant four leaf Radix Adenophorae (Radix Glehniae), Folium Pruni Radix Adenophorae (Radix Glehniae) or its congener, be used as medicine with root.Pharmacological action: 1, this product has phlegm-dispelling functions, sustainable more than 4 hours.2, the 1:40 immersion of Radix Adenophorae (Radix Glehniae) is without haemolysis, but with erythrocyte effect variable color, turbidity sediment can occur.Nature and flavor: sweet are cool.Function cures mainly: clearing away heat and nourishing YIN, nourishing the lung to arrest cough.Cure mainly tracheitis, pertussis, cough due to lung-heat, cough up phlegm yellow thick.
Semen Oroxyli: base is former: be the dry mature seed of Bignoniaceae plant oroxylum indicum.Nature and flavor: bitter, cold.Gui Jing: enter lung, Liver Channel.Function cures mainly: lung moistening, soothing liver-QI, stomach function regulating, granulation promoting.Control cough, sore throat, hoarseness, stomachache due to hyperactive liver-QI attacking the stomach, the open sore part is not held back.
Flos Chrysanthemi Indici: base is former: be root or the herb of Compositae Dendranthema Flos Chrysanthemi Indici or lavandulaleaf dendranthema herb.The property of medicine: bitter, acrid, cold.Return liver, heart channel.Function cures mainly: heat-clearing and toxic substances removing, improving eyesight.Cure mainly flu, dysentery, carbuncle, furuncle, conjunctival congestion and swelling pain, dizzy, scrofula, eczema.
embodiment 1the Chinese medicine preparation for the treatment of pharyngitis, is prepared from by following bulk drugs, is weight portion (200g/ part): Radix Ophiopogonis 15 parts; Pseudobulbus Coelogynes corymbosae 7 parts; Alternanthera sessilis (L.) DC. 15 parts; Radix Aneurolepidii 10 parts; Fructus Corni 9 parts; Herba seu Radix Nothopanacis delavayi 12 parts; Radix Primulae sieboldii 10 parts; Herba Clinopodii megalanthi 12 parts; Radix Scutellariae 11 parts; Indigo Naturalis 8 parts; Neoalsomitra integrifoliola (Cogn.) Hucth. 11 parts; Herba Veronicastri 8 parts; Radix Adenophorae (Radix Glehniae) 13 parts; Semen Oroxyli 9 parts; Flos Chrysanthemi Indici 10 parts.
The preparation method of the Chinese medicine decoction of above-mentioned treatment pharyngitis is:
(1) Fructus Corni is cleaned, and adds yellow wine and mixes thoroughly (Fructus Corni: yellow wine=5:1), stew to moisten, and puts suitable to steam in container, steams and exhausts to wine, take out dry, smash to pieces for subsequent use by Steam Heating; Semen Oroxyli and Indigo Naturalis are ground into fine powder respectively, for subsequent use;
(2) the raw material medicated powder mixing after step (1) being processed, sieves, is placed in penetrating bag, for subsequent use;
(3) Radix Ophiopogonis, Radix Aneurolepidii, Herba seu Radix Nothopanacis delavayi, Radix Primulae sieboldii, Radix Scutellariae, Neoalsomitra integrifoliola (Cogn.) Hucth., Radix Adenophorae (Radix Glehniae) and Flos Chrysanthemi Indici are together placed in Chinese medicine pan, the clear water adding 4 times amount soaks 1.5 hours, then the penetrating bag of step (2) gained is added, intense fire is heated to boil, turn slow fire boiling twice, each each decoction 48 minutes, merges twice decocting liquid, filter, obtain decocting liquid 1;
(4) Pseudobulbus Coelogynes corymbosae, Alternanthera sessilis (L.) DC., Herba Clinopodii megalanthi and Herba Veronicastri are added clear water and do not have powder, slow fire boiling twice, each each decoction 15 minutes, collecting decoction, filters, obtains decocting liquid 2;
(5) by decocting liquid 1 and decocting liquid also 2-in-1, be evaporated to 1/2 of original volume, dry heat sterilization, cooling, encapsulation, to obtain final product.
The instructions of taking of gained decoction of the present invention is: once a day, each 100-150mL, warmly takes, 7 days courses for the treatment of.
Model case: king XX, male, 35 years old, reporter.Patient is to our hospital on October 11st, 2011.Patient suffers from pharyngitis and has a surplus for 3 years, once takes the Drug therapys such as YANDEPING, also once uses liniment, but all fails thoroughly to cure.Patient introduced my institute through ward mate and checked treatment afterwards.Check: patient is pharyngeal foreign body sensation, pain when swallowing, if any obstruction, fullness in the chest, indigestion and loss of appetite, expectoration, body of the tongue is partially single, and the micro-Huang of tongue is sliding, and weak pulse is unable.Be diagnosed as chronic pharyngitis.
Take the Chinese medicine decoction of the present embodiment gained treatment pharyngitis, instructions of taking: once a day, each 100-150mL, warmly takes, 7 days courses for the treatment of.After taking two courses for the treatment of, patient is uncomfortable in chest, and expectoration symptom is alleviated greatly, and pharyngeal discomfort obviously alleviates, and continues to take two courses for the treatment of, and check that patient's pharyngitis symptom all disappears, patient's self-induction is fully recovered, and pay a return visit after two months, patient is without recurrence.
embodiment 2the Chinese medicine preparation for the treatment of pharyngitis, is prepared from by following bulk drugs, is weight portion (120g/ part): Radix Ophiopogonis 20 parts; Pseudobulbus Coelogynes corymbosae 13 parts; Alternanthera sessilis (L.) DC. 25 parts; Radix Aneurolepidii 15 parts; Fructus Corni 16 parts; Herba seu Radix Nothopanacis delavayi 16 parts; Radix Primulae sieboldii 14 parts; Herba Clinopodii megalanthi 18 parts; Radix Scutellariae 16 parts; Indigo Naturalis 13 parts; Neoalsomitra integrifoliola (Cogn.) Hucth. 16 parts; Herba Veronicastri 13 parts; Radix Adenophorae (Radix Glehniae) 20 parts; Semen Oroxyli 14 parts; Flos Chrysanthemi Indici 15 parts.
The preparation method of the medicine pill of above-mentioned treatment pharyngitis is:
(1) Fructus Corni is cleaned, and adds yellow wine and mixes thoroughly (Fructus Corni: yellow wine=5:1), stew to moisten, and puts suitable to steam in container, steams and exhausts to wine, take out dry, smash to pieces for subsequent use by Steam Heating; Semen Oroxyli and Indigo Naturalis are ground into fine powder respectively, for subsequent use;
(2) get scutellaria tablet, put in pot, intense fire heats, and when frying to pitchy, spray clear water goes out most Mars, takes out, dries, smash to pieces for subsequent use;
(3) crude drug except Fructus Corni, Semen Oroxyli, Indigo Naturalis and Radix Scutellariae is placed in Chinese medicine extracting tank, the mass concentration adding 5 times amount is the ethanol of 70%, reflux, extract, twice, first time extracts 25 minutes, and second time is extracted 15 minutes, merge extractive liquid, filter, filtrate is for subsequent use;
(4) above-mentioned filtrate is concentrated into the clear paste that density is about 1.20g/mL, add the raw material medicated powder after step (1) and step (2) process, add sucrose fine while stirring, stir, be processed into the pill of Semen Glycines size, dry, encapsulation, to obtain final product.
The instructions of taking of gained medicine pill of the present invention is: every day three times, each 6-10 ball, 7 days courses for the treatment of.
embodiment 3the Chinese medicine preparation for the treatment of pharyngitis, is prepared from by following bulk drugs, is weight portion (180g/ part): Radix Ophiopogonis 16 parts; Pseudobulbus Coelogynes corymbosae 9 parts; Alternanthera sessilis (L.) DC. 18 parts; Radix Aneurolepidii 11 parts; Fructus Corni 11 parts; Herba seu Radix Nothopanacis delavayi 13 parts; Radix Primulae sieboldii 11 parts; Herba Clinopodii megalanthi 13 parts; Radix Scutellariae 13 parts; Indigo Naturalis 10 parts; Neoalsomitra integrifoliola (Cogn.) Hucth. 13 parts; Herba Veronicastri 9 parts; Radix Adenophorae (Radix Glehniae) 15 parts; Semen Oroxyli 11 parts; Flos Chrysanthemi Indici 11 parts.
The preparation method of the traditional Chinese medicine thick paste agent of above-mentioned treatment pharyngitis is:
(1) Semen Oroxyli is cleaned, and slow fire heats, and stir-fry limit, limit is spilled into saline solution (Semen Oroxyli: Sal=50:1), and frying extremely faint yellow is degree, takes out, smashs to pieces, for subsequent use; Get scutellaria tablet, fry with high heat to complete burnt, cool, smash to pieces, for subsequent use; Indigo Naturalis is ground into fine powder, for subsequent use;
(2) medical material after step (1) being processed, be together placed in Chinese medicine extracting tank with surplus stock medicine, add the clear water of 10 times amount, big fire is heated to boil, and a turn little fire decocts three times, and each each decoction 24 minutes, merges twice decocting liquid, filter, obtain filtrate, for subsequent use;
(3) during above-mentioned filtrate reduced in volume to 80 DEG C, relative density is the thick paste of 1.30-1.33, sterilizing, and encapsulation, to obtain final product.
The instructions of taking of gained traditional Chinese medicine thick paste of the present invention agent is: every day three times, each 1-2 soupspoon, and warm water is taken after mixing it with water, 7 days courses for the treatment of.
Model case: Liu XX, man, 45 years old, workman.Patient is to our hospital on March 22nd, 2013.Patient's readme: suffer from chronic pharyngitis and have a surplus for 5 years, recurrent exerbation, cough, expectoration constantly all the year.Once took antiviral and antiinflammatory class western medicine, after treatment, expectoration obviously reduces, but sputum becomes thickness, is difficult to cough with asthma.Feel pharyngeal itching afterwards, pain when swallowing, then cut out various Western medicine.Introduce my institute through friend and check treatment.Check: the pharyngeal pain of patient is itched, and has burning sensation, expectoration is sticky expectorant a little, and pharyngeal congestion is kermesinus, and mucosa is dry, red tongue, thin fur, thready and rapid pulse.Connective tissue and lymphadenosis under mucosa, mucous gland is loose.Make a definite diagnosis chronic pharyngitis errorless.
Take the traditional Chinese medicine thick paste agent of the present embodiment gained treatment pharyngitis, instructions of taking: every day three times, each 1-2 soupspoon, warm water is taken after mixing it with water, 7 days courses for the treatment of.After taking two courses for the treatment of, patient's cough, expectoration, obviously to alleviate, the amount of receiving increases, and spirit can.Take again one the course for the treatment of medicine, patient's lesions position obviously improves and is tending towards normal.Following the service is consolidated a course for the treatment of, does not occur any discomfort when patient takes, and patient's self-induction is fully recovered.So far without recurrence.
embodiment 4the Chinese medicine preparation for the treatment of pharyngitis, is prepared from by following bulk drugs, is weight portion (140g/ part): Radix Ophiopogonis 19 parts; Pseudobulbus Coelogynes corymbosae 11 parts; Alternanthera sessilis (L.) DC. 22 parts; Radix Aneurolepidii 14 parts; Fructus Corni 14 parts; Herba seu Radix Nothopanacis delavayi 15 parts; Radix Primulae sieboldii 13 parts; Herba Clinopodii megalanthi 17 parts; Radix Scutellariae 14 parts; Indigo Naturalis 11 parts; Neoalsomitra integrifoliola (Cogn.) Hucth. 14 parts; Herba Veronicastri 12 parts; Radix Adenophorae (Radix Glehniae) 18 parts; Semen Oroxyli 12 parts; Flos Chrysanthemi Indici 14 parts.
The preparation method of the Chinese medicinal tablet of above-mentioned treatment pharyngitis is:
(1) various crude drug is taken by formula proportion, fully dry, grind into powder, cross 110 mesh sieves, obtain mixed powder;
(2) above-mentioned medicated powder is measured according to 0.4g/ sheet, make tablet dosage form according to the preparation for processing of tablet.
The instructions of taking of gained Chinese medicinal tablet of the present invention is: every day three times, each 4-6 sheet, and warm water takes, 7 days courses for the treatment of.
embodiment 5the Chinese medicine preparation for the treatment of pharyngitis, is prepared from by following bulk drugs, is weight portion (160g/ part): Radix Ophiopogonis 17.5 parts; Pseudobulbus Coelogynes corymbosae 10 parts; Alternanthera sessilis (L.) DC. 20 parts; Radix Aneurolepidii 12.5 parts; Fructus Corni 12.5 parts; Herba seu Radix Nothopanacis delavayi 14 parts; Radix Primulae sieboldii 12 parts; Herba Clinopodii megalanthi 15 parts; Radix Scutellariae 13.5 parts; Indigo Naturalis 10.5 parts; Neoalsomitra integrifoliola (Cogn.) Hucth. 13.5 parts; Herba Veronicastri 10.5 parts; Radix Adenophorae (Radix Glehniae) 16.5 parts; Semen Oroxyli 11.5 parts; Flos Chrysanthemi Indici 12.5 parts.
The preparation method of the Chinese medicine decoction of above-mentioned treatment pharyngitis is:
(1) Fructus Corni is cleaned, and adds yellow wine and mixes thoroughly (Fructus Corni: yellow wine=5:1), stew to moisten, and puts suitable to steam in container, steams and exhausts to wine, take out dry, smash to pieces for subsequent use by Steam Heating; Semen Oroxyli and Indigo Naturalis are ground into fine powder respectively, for subsequent use;
(2) the raw material medicated powder mixing after step (1) being processed, sieves, is placed in penetrating bag, for subsequent use;
(3) Radix Ophiopogonis, Radix Aneurolepidii, Herba seu Radix Nothopanacis delavayi, Radix Primulae sieboldii, Radix Scutellariae, Neoalsomitra integrifoliola (Cogn.) Hucth., Radix Adenophorae (Radix Glehniae) and Flos Chrysanthemi Indici are together placed in Chinese medicine pan, the clear water adding 6 times amount soaks 2.0 hours, then the penetrating bag of step (2) gained is added, intense fire is heated to boil, turn slow fire boiling twice, each each decoction 59 minutes, merges twice decocting liquid, filter, obtain decocting liquid 1;
(4) Pseudobulbus Coelogynes corymbosae, Alternanthera sessilis (L.) DC., Herba Clinopodii megalanthi and Herba Veronicastri are added clear water and do not have powder, slow fire boiling twice, each each decoction 20 minutes, collecting decoction, filters, obtains decocting liquid 2;
(5) by decocting liquid 1 and decocting liquid also 2-in-1, be evaporated to 1/2 of original volume, dry heat sterilization, cooling, encapsulation, to obtain final product.
The instructions of taking of gained Chinese medicine decoction of the present invention is: once a day, each 100-150mL, warmly takes, 7 days courses for the treatment of.
test example 1the clinical practice of the Chinese medicine preparation (embodiment 5) of gained treatment pharyngitis of the present invention: in October ,-2013 in March, 2010, screen in 4 hospitals the patient that 300 examples suffer from acute/chronic pharyngitis.Diagnostic criteria: Western medicine diagnose standard: (1) is pharyngeal various sense of discomfort, as dry, scorching hot, hypodynia, micro-ly to itch, foreign body sensation, time light time heavy, normal expectoration is sticky expectorant a little; (2) connective tissue and lymphadenosis under mucosa, mucous gland is loose, hypersecretion.Tcm diagnosis standard: exacerbation of symptoms after the dry pain of throat, scorching hot, polylogia, chokes and coughs without expectorant, in the afternoon and dusk time symptom Minxian County.Pharyngeal congestion is kermesinus, and mucosa is dry, red tongue, thin fur, thready and rapid pulse.Male patient's totally 169 examples in all patients, female patient is totally 131 examples; Oldest 70 years old, minimum 22 years old of age, 48.4 ± 3.6 years old mean age.All patients are divided into two groups at random, experimental group and matched group.Two groups of patients in sex, age, the course of disease, the state of an illness etc. difference there are no significant (P), there is comparability.Wherein experimental group takes the Chinese medicine decoction of gained of the present invention treatment pharyngitis, and instructions of taking is: once a day, each 100-150mL, warmly takes, 7 days courses for the treatment of.Matched group takes other medicine (as conventional medication such as azithromycin capsule, Yanyan slice, throat-benefiting granules).Observe three courses for the treatment of of treatment altogether.Efficacy assessment standard: clinical cure: clinical symptoms and sign all disappear, checks that the congested phenomenon of known pharyngeal mucosa disappears; Effective: clinical symptoms and sign disappear substantially, check that the congested phenomenon of known pharyngeal mucosa is obviously alleviated; Invalid: clinical symptoms and sign are without improvement or increase the weight of.Total effective rate=(clinical cure number of cases+effectively number of cases) ∕ total inspection case load × 100%.Therapeutic outcome is as shown in table 1:
Table 1: the therapeutic outcome of experimental group and matched group patient
Therapeutic effect: clinical cure 142 example (71%), invalid 4 examples (2%) of effective 54 examples (27%), total effective rate 98%.Successful is better than matched group.
The present invention by Radix Ophiopogonis, Pseudobulbus Coelogynes corymbosae, Alternanthera sessilis (L.) DC., Radix Aneurolepidii, Fructus Corni, Herba seu Radix Nothopanacis delavayi, Radix Primulae sieboldii, Herba Clinopodii megalanthi, Radix Scutellariae, Indigo Naturalis and Neoalsomitra integrifoliola (Cogn.) Hucth. etc. totally 15 taste primary raw material medicines be prepared from.Fang Zhong, Radix Ophiopogonis, Radix Scutellariae are used for dryness of the lung dry cough; Pseudobulbus Coelogynes corymbosae and Herba seu Radix Nothopanacis delavayi clearing and antitussive, hemostasis analgesic therapy; Alternanthera sessilis (L.) DC. and Radix Aneurolepidii clearing away heat and cooling blood, inducing diuresis and reducing edema; Indigo Naturalis heat-clearing and toxic substances removing, removing heat from blood, arresting convulsion; Neoalsomitra integrifoliola (Cogn.) Hucth. heat-clearing and toxic substances removing, anti-inflammation and sterilization, convergence pain relieving; Herba Veronicastri have expelling wind and relieving convulsion, dissipating phlegm and resolving masses, resolving toxin and disinhibiting the throat effect; Radix Adenophorae (Radix Glehniae) clearing away heat and nourishing YIN, nourishing the lung to arrest cough, is used for treating acute/chronic pharyngitis.The ingenious prescription of 15 taste Chinese herbal medicine, scientific compatibility, medicine is coordinated mutually, plays heat-clearing and toxic substances removing altogether, specially good effect that sore-throat relieving reduces phlegm.Take three courses for the treatment of in experimental group, effective percentage can reach 98%, and matched group is only 78%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat the Chinese medicine preparation of pharyngitis, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Ophiopogonis 15-20; Pseudobulbus Coelogynes corymbosae 7-13; Alternanthera sessilis (L.) DC. 15-25; Radix Aneurolepidii 10-15; Fructus Corni 9-16; Herba seu Radix Nothopanacis delavayi 12-16; Radix Primulae sieboldii 10-14; Herba Clinopodii megalanthi 12-18; Radix Scutellariae 11-16; Indigo Naturalis 8-13; Neoalsomitra integrifoliola (Cogn.) Hucth. 11-16; Herba Veronicastri 8-13; Radix Adenophorae (Radix Glehniae) 13-20; Semen Oroxyli 9-14; Flos Chrysanthemi Indici 10-15.
2. the Chinese medicine preparation for the treatment of pharyngitis as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Ophiopogonis 16-19; Pseudobulbus Coelogynes corymbosae 9-11; Alternanthera sessilis (L.) DC. 18-22; Radix Aneurolepidii 11-14; Fructus Corni 11-14; Herba seu Radix Nothopanacis delavayi 13-15; Radix Primulae sieboldii 11-13; Herba Clinopodii megalanthi 13-17; Radix Scutellariae 13-14; Indigo Naturalis 10-11; Neoalsomitra integrifoliola (Cogn.) Hucth. 13-14; Herba Veronicastri 9-12; Radix Adenophorae (Radix Glehniae) 15-18; Semen Oroxyli 11-12; Flos Chrysanthemi Indici 11-14.
3. the Chinese medicine preparation for the treatment of pharyngitis as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Ophiopogonis 17.5; Pseudobulbus Coelogynes corymbosae 10; Alternanthera sessilis (L.) DC. 20; Radix Aneurolepidii 12.5; Fructus Corni 12.5; Herba seu Radix Nothopanacis delavayi 14; Radix Primulae sieboldii 12; Herba Clinopodii megalanthi 15; Radix Scutellariae 13.5; Indigo Naturalis 10.5; Neoalsomitra integrifoliola (Cogn.) Hucth. 13.5; Herba Veronicastri 10.5; Radix Adenophorae (Radix Glehniae) 16.5; Semen Oroxyli 11.5; Flos Chrysanthemi Indici 12.5.
4. the Chinese medicine preparation of the treatment pharyngitis as described in claim 1-3, is characterized in that, be made into pharmaceutically acceptable decoction, preparation method is as follows:
(1) Fructus Corni is cleaned, and adds yellow wine and mixes thoroughly (Fructus Corni: yellow wine=5:1), stew to moisten, and puts suitable to steam in container, steams and exhausts to wine, take out dry, smash to pieces for subsequent use by Steam Heating; Semen Oroxyli and Indigo Naturalis are ground into fine powder respectively, for subsequent use;
(2) the raw material medicated powder mixing after step (1) being processed, sieves, is placed in penetrating bag, for subsequent use;
(3) Radix Ophiopogonis, Radix Aneurolepidii, Herba seu Radix Nothopanacis delavayi, Radix Primulae sieboldii, Radix Scutellariae, Neoalsomitra integrifoliola (Cogn.) Hucth., Radix Adenophorae (Radix Glehniae) and Flos Chrysanthemi Indici are together placed in Chinese medicine pan, the clear water adding 4-8 times amount soaks (clear water preferably adding 6 times amount soaks), then the penetrating bag of step (2) gained is added, intense fire is heated to boil, turn slow fire boiling twice, each each decoction 48-70 minute, merges twice decocting liquid, filter, obtain decocting liquid 1;
(4) Pseudobulbus Coelogynes corymbosae, Alternanthera sessilis (L.) DC., Herba Clinopodii megalanthi and Herba Veronicastri are added clear water and do not have powder, slow fire boiling twice, each respectively decoction 15-25 minute (preferably each each decoction 20 minutes), collecting decoction, filtration, obtains decocting liquid 2;
(5) by decocting liquid 1 and decocting liquid also 2-in-1, be evaporated to 1/2 of original volume, dry heat sterilization, cooling, encapsulation, to obtain final product.
5. the preparation method of the Chinese medicine decoction for the treatment of pharyngitis according to claim 4, it is characterized in that, the time of soaking in step (3) is 1.5-2.5 hour (the preferred time of soaking is 1.8-2.2 hour, and the time of the immersion be more preferably is 2.0 hours).
6. the preparation method of the Chinese medicine decoction for the treatment of pharyngitis according to claim 4, is characterized in that, each respectively decoction 54-64 minute (preferably each each decoction 59 minutes) in step (3).
7. the Chinese medicine preparation of the treatment pharyngitis as described in claim 1-3, is characterized in that, be made into pharmaceutically acceptable pill, preparation method is as follows:
(1) Fructus Corni is cleaned, and adds yellow wine and mixes thoroughly (Fructus Corni: yellow wine=5:1), stew to moisten, and puts suitable to steam in container, steams and exhausts to wine, take out dry, smash to pieces for subsequent use by Steam Heating; Semen Oroxyli and Indigo Naturalis are ground into fine powder respectively, for subsequent use;
(2) get scutellaria tablet, put in pot, intense fire heats, and when frying to pitchy, spray clear water goes out most Mars, takes out, dries, smash to pieces for subsequent use;
(3) crude drug except Fructus Corni, Semen Oroxyli, Indigo Naturalis and Radix Scutellariae is placed in Chinese medicine extracting tank, add the ethanol (preferably adding the ethanol of 5 times amount) of 4-6 times amount, reflux, extract, twice, first time extracts 20-30 minute (preferably first time extracts 25 minutes), second time is extracted 12-18 minute (preferably second time is extracted 15 minutes), merge extractive liquid, filter, filtrate is for subsequent use;
(4) above-mentioned filtrate is concentrated into the clear paste that density is about 1.20g/mL, add the raw material medicated powder after step (1) and step (2) process, add sucrose fine while stirring, stir, be processed into the pill of Semen Glycines size, dry, encapsulation, to obtain final product.
8. the preparation method of the medicine pill for the treatment of pharyngitis according to claim 7, it is characterized in that, in step (3), the mass concentration of added ethanol is the mass concentration of the preferred added ethanol of 60%-80%(is 65%-75%, and the mass concentration of the added ethanol be more preferably is 70%).
9. the Chinese medicine preparation of the treatment pharyngitis as described in claim 1-3, is characterized in that, be made into pharmaceutically acceptable thick paste agent, preparation method is as follows:
(1) Semen Oroxyli is cleaned, and slow fire heats, and stir-fry limit, limit is spilled into saline solution (Semen Oroxyli: Sal=50:1), and frying extremely faint yellow is degree, takes out, smashs to pieces, for subsequent use; Get scutellaria tablet, fry with high heat to complete burnt, cool, smash to pieces, for subsequent use; Indigo Naturalis is ground into fine powder, for subsequent use;
(2) medical material after step (1) being processed, together Chinese medicine extracting tank is placed in surplus stock medicine, add the clear water (preferably adding the clear water of 10 times amount) of 8-12 times amount, big fire is heated to boil, and turns little fire and decocts three times, respectively decocts 20-28 minute (preferably each respectively decoction 24 minutes) at every turn, merge twice decocting liquid, filter, obtain filtrate, for subsequent use;
(3) during above-mentioned filtrate reduced in volume to 80 DEG C, relative density is the thick paste of 1.30-1.33, sterilizing, and encapsulation, to obtain final product.
10. the Chinese medicine preparation of the treatment pharyngitis as described in claim 1-3, is characterized in that, be made into pharmaceutically acceptable tablet, preparation method is as follows:
(1) various crude drug is taken by formula proportion, fully dry, grind into powder, cross 100-120 mesh sieve (preferred mistake 110 mesh sieve), obtain mixed powder;
(2) above-mentioned medicated powder is measured according to 0.3-0.5g/ sheet (preferably according to 0.4g/ sheet), make tablet dosage form according to the preparation for processing of tablet.
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| KR101161479B1 (en) * | 2009-08-20 | 2012-07-02 | 아주대학교산학협력단 | Pharmaceutical composition comprising chaff vinegar for preventing or treating inflammatory disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101161479B1 (en) * | 2009-08-20 | 2012-07-02 | 아주대학교산학협력단 | Pharmaceutical composition comprising chaff vinegar for preventing or treating inflammatory disease |
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| 张兴儒: "《新编临床常见病偏方验方全书》", 28 February 2008, 上海科学技术文献出版社 * |
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