CN104383024A - Chronic dysentery preparation capable of invigorating spleen and supplementing qi and preparation method - Google Patents
Chronic dysentery preparation capable of invigorating spleen and supplementing qi and preparation method Download PDFInfo
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- CN104383024A CN104383024A CN201410582563.6A CN201410582563A CN104383024A CN 104383024 A CN104383024 A CN 104383024A CN 201410582563 A CN201410582563 A CN 201410582563A CN 104383024 A CN104383024 A CN 104383024A
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Abstract
The invention discloses chronic dysentery preparation capable of invigorating spleen and supplementing qi and a preparation method thereof. The chronic dysentery preparation is mainly prepared from the following drug substances in parts by weight: 3-6 parts of coptis chinensis, 10-20 parts of the root of Chinese pulsatilla, 5-15 parts of radices saussureae, 15-25 parts of capitate knotweed herb, 6-12 parts of Java bishopwood root-bark branchlet and leaf, 12-20 parts of astragalus membranaceus, 6-10 parts of griffith streptocaulon root or leaf, 8-15 parts of cassia twig, 18-40 parts of herba portulacae, 6-12 parts of casuarina equisetifolia and 6-15 parts of thyrocarpus sampsonii hance. The chronic dysentery preparation is obvious in curative effect, free of toxic or side effect and short in course of treatment and becomes effective rapidly; chronic dysentery does not relapse when cured by adopting the chronic dysentery preparation.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of chronic dysentery invigorating the spleen and benefiting QI preparation and preparation method thereof.
Background technology
Chronic dysentery is common clinical.All courses of disease, more than 2 months persons, are called chronic dysentery.Majority be because of walking dysentery treatment thoroughly or patient suffer from the sick body matter such as malnutrition, rickets, anemia, parasite more weak caused by.Such patient is many without high heat, sometimes can occur stomachache, diarrhoea, vomiting and low grade fever, stool every day 3-5 time, can have and normally just just alternately occur with bloody purulent stool with mucus.Chronic dysentery patient, because long-term nutrition is bad, resistance is poor, easily merges other bacteriological infection, as pneumonia, tuberculosis etc.
The traditional Chinese medical science is thought, primary disease is many because of outward by damp and hot, gas that epidemic disease is malicious, internal injury diet raw food, and impairing the spleen and stomach and internal organs form, and belongs to " intestinal is warded off, dysentery " category." the bright opinion of the lunar sun of Plain Questions " cloud: " eating and drinking without temperance, daily life frequently ... under let out for offering to, for a long time for intestinal is warded off." " Zhengzi Huibu " point out: " the intestinal person of warding off calls damp and hot amassing in intestinal.Namely modern dysentery is also, therefore says and do not become dysentery without disease, dysentery be wet, heat, food stagnation three ".Treatment should be taked the method for determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, Jing-Yue Complete Works cloud: " allly control dysentery, when examining deficiency and excess, distinguishing cold and heat, the maximum relation of this dysentery, if four fail to understand, then killing a person very easily also." the dialectical head of former primary disease distinguishes cold, hot, empty, in fact, facing card according to stomachache, tenesmus, dysentery color, and ought refer and synthesize tongue arteries and veins and distinguish, usually can be divided into 6 types.(1) dysentery due to damp-heat: method for the treatment of: clearing away heat and eliminating dampness is detoxified, and is aided with regulating QI promoting the circulation of blood.Side's medicine: just reinstate Radix Paeoniae Decoction plus-minus.Side Rhizoma Coptidis, the removing toxic substances of Radix Scutellariae clearing away heat and eliminating dampness; Radix Angelicae Sinensis, Radix Paeoniae, Radix Glycyrrhizae promoting the circulation of blood and battalion; The Radix Aucklandiae, Semen Arecae circulation of qi promoting intestinal stasis relieving; Radix Et Rhizoma Rhei removing the relative excess heat.Have the exterior syndrome person such as fever with aversion to cold, headache concurrently, add Radix Puerariae, Fructus Forsythiae, Herba Schizonepetae etc.The stagnant person of being accompanied by dyspepsia, adds six bent, Fructus Crataegis.As thermogravimetric dysentery, red how white few, or pure bloody dysentery, generate heat higher, thirst and drinking, red tongue with yellow fur, slippery and rapid pulse person can use Radix Pulsatillae Decoction heat-clearing and toxic substances removing, drinks and adds Flos Lonicerae, Radix Paeoniae, Fructus Aurantii Immaturus, Radix Glycyrrhizae etc.(2) fulminant dysentery: method for the treatment of: clearing away heat,cooling blood and removing toxin.Side's medicine: Radix Pulsatillae Decoction is added and subtracted.Side uses Radix Pulsatillae removing pathogenic heat from blood and toxic substance from the body; Rhizoma Coptidis, Cortex Phellodendri, Cortex Fraxini bitter cold removing dampness heat clearing away.The clearing away heat and cooling blood such as Flos Lonicerae, Radix Scutellariae, Radix Paeoniae Rubra, Cortex Moutan can be added.As unconsciousness due to high fever is twitched, ZIXUEDAN can be taken and relieve dizziness, high fever, infantile convulsions, epilepsy, etc. with clearing heat in YING system.As pale complexion, extreme cold of the limbs, hyperhidrosis, dyspnea with rapid and short breath, thready pulse weak person is that positive exogenous pathogen falls into, the card of unconsciousness and collapse, suddenly can take shenfu decoction or SHENGMAI SAN treatment.After the depletion syndrome is removed, still by former card treatment.In fulminant dysentery and dysentery due to damp-heat process, if occur, diet does not enter, nausea and vomiting, metal fatigue syndrome, claims " fasting dysentery ", is because epidemic disease caused by damp-heat pathogen poison pents up in intestinal, above attacks in stomach, stomach-QI being unable to descend normally, caused by failure of the spleen to transport and transform.Availablely open keeping silent loose plus-minus.Side decocts water with Rhizoma Coptidis, Shi Fu Chang, Poria, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Folium Nelumbinis Basis, Radix Et Rhizoma Rhei etc. and repeatedly slowly swallows on a small quantity, with the sending down the abnormal ascending QI that detoxifies.Gas the moon consumption as stomach is hindered more notably, can drink and add Radix Ginseng, Radix Ophiopogonis, Herba Dendrobii, Radix Adenophorae (Radix Glehniae) etc., support Tianjin with stomach function regulating.As " mouth of keeping silent " symptom resolution, still can treat by fulminant dysentery or dysentery due to damp-heat.(3) deficiency of YIN dysentery: method for the treatment of: consolidating YIN expels the heat-evil, righting dysentery relieving.Side's medicine: Chinese goldthread colla corii asini decoction closes zhuche pills and goes Rhizoma Zingiberis.Colla Corii Asini, Rhizoma Coptidis, Radix Scutellariae in side, consolidating YIN dysentery relieving; Radix Paeoniae, Radix Angelicae Sinensis regulating blood flow to alleviate pains; Add Fructus Trichosanthis intestine moistening and rush down promoting the circulation of QI machine.Assertive evidence should not be attacked, and exempts from wound Kidney-Yin.Desirable sour and sweet drugs can transforme into YIN method or control from foster vital essence.(4) chronic dysentery with frequent relapse: method for the treatment of: invigorating the spleen and benefiting QI, Qinghua is damp and hot.Damp and hot based on Qinghua during outbreak, based on invigorating the spleen and benefiting QI when stopping.Side's medicine: can add and subtract with Radix Paeoniae Decoction or Radix Pulsatillae Decoction during outbreak.Xianglian Wan can be closed with invigorating the spleen and regulating the stomach soup when stopping.(5) deficiency and coldness dysentery: method for the treatment of: warming and recuperating the spleen and kidney, helps admittedly to take off.Side's medicine: Taohua Tang He Yangzang Tonga subtracts.Square Radix Codonopsis, Rhizoma Atractylodis Macrocephalae replenishing QI to invigorate the spleen; Rhizoma Zingiberis warming spleen and stomach for dispelling cold; Cortex Cinnamomi, Semen Myristicae the kidney warming antidiarrheal; Radix Aucklandiae regulating QI reason spleen; Radix Angelicae Sinensis, Radix Paeoniae Alba regulating blood flow to alleviate pains; Fructus Chebulae, Halloysitum Rubrum, Pericarpium Papaveris relieving diarrhea with astringents take off admittedly; Semen oryzae sativae nourishing the stomach and in; Radix Glycyrrhizae Preparata and in.
Application publication number CN 101757534 A(application number 200810237822.6) Chinese patent literature disclose a kind of Chinese medicine for the treatment of chronic dysentery, it is with Radix Codonopsis, the Radix Paeoniae Alba, Semen Myristicae, Fructus Chebulae, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Pericarpium Granati, Cortex Cinnamomi, the Radix Aucklandiae, Radix Glycyrrhizae Preparata for raw material, forms according to the different qualities of every taste Chinese medicine and different ratio modulation.Application publication number CN 104096159 A(application number 201410343777.8) Chinese patent literature disclose the viable bacteria mixture of a kind of relieve chronic dysentery and bowel dysfunction, take off the primary raw material stating weight proportion to be prepared from: Fructus Evodiae 2-4 part, Fructus Gardeniae 3-10 part, Massa Medicata Fermentata 4-12 part, Fructus Schisandrae Chinensis 5-12 part, Poria cum Radix Pini 4-12 part, Fructus Crataegi 6-15 part, Herba Dendrobii 6-9 part, Fructus Amomi 5-12 part, Nodus Nelumbinis Rhizomatis 3-10 part, bacillus cereus 0.3-1.0 part.Application publication number CN 103405703 A(application number 201310275325.6) Chinese patent literature provide a kind of Chinese medicine pill for the treatment of chronic dysentery, comprise following weight ratio composition Chinese medicine component: Radix Scutellariae 10-15 part, Rhizoma Atractylodis Macrocephalae 12-18 part, 15 parts, Poria, Massa Medicata Fermentata 5 parts, the Radix Aucklandiae 8 parts, Fructus Amomi 10-15 part, Rhizoma Dioscoreae 15-20 part, 10 parts, Flos Sophorae, Radix Platycodonis 5 parts, Cortex Ailanthi difficult to understand 20 parts, Radix Sanguisorbae 10-15 part, Herba Portulacae 20 parts, 6 parts, Radix Glycyrrhizae; Additionally provide the preparation method of pill.
In a word, the chronic dysentery course of disease is long, recurrent exerbation or protracted course of disease, and clinical in antibiotic therapy at present, bad for chronic dysentery curative effect, toxic and side effects is large.And treatment by Chinese herbs chronic dysentery is longer for the course for the treatment of.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of chronic dysentery invigorating the spleen and benefiting QI preparation and preparation method thereof.Said preparation is evident in efficacy, have no side effect, short treating period, instant effect, without recurrence.
Technical scheme of the present invention is:
Chronic dysentery invigorating the spleen and benefiting QI preparation, takes off the primary raw material medicine stating weight proportion and is prepared from: Rhizoma Coptidis 3-6, Radix Pulsatillae 10-20, Radix Aucklandiae 5-15, Herba Polygoni Capitati 15-25, Ramulus et Folium Bischofiae Javanicae 6-12, Radix Astragali 12-20, Radix Streptocauli Griffithii 6-10, Ramulus Cinnamomi 8-15, Herba Portulacae 18-40, Casuarina equisetifolia L. 6-12, Radix Thyrocarpi sampsonii 6-15.
Chronic dysentery invigorating the spleen and benefiting QI preparation, preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Rhizoma Coptidis 3.5-5, Radix Pulsatillae 12-16, Radix Aucklandiae 7-12, Herba Polygoni Capitati 18-20, Ramulus et Folium Bischofiae Javanicae 8-11, Radix Astragali 14-18, Radix Streptocauli Griffithii 7-9, Ramulus Cinnamomi 9-11, Herba Portulacae 25-35, Casuarina equisetifolia L. 8-11, Radix Thyrocarpi sampsonii 9-13.
Chronic dysentery invigorating the spleen and benefiting QI preparation, the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: Rhizoma Coptidis 4, the Radix Pulsatillae 14, the Radix Aucklandiae 9, Herba Polygoni Capitati 19, Ramulus et Folium Bischofiae Javanicae 10, the Radix Astragali 16, Radix Streptocauli Griffithii 8, Ramulus Cinnamomi 10, Herba Portulacae 28, Casuarina equisetifolia L. 9, Radix Thyrocarpi sampsonii 12.
Present invention also offers the preparation method aforementioned chronic dysentery invigorating the spleen and benefiting QI preparation being made pharmaceutically acceptable decoction, powder, thick paste agent and pill.
The preparation method of described decoction is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 10-30 minute (being preferably soaked in water 20 minutes), drag in basket, add a cover wet cloth profit 3-6 hour (preferably add a cover wet cloth and moisten 4 hours), take out, section, then soak 1-3 hour (preferably soaking 2 hours with wine again) with wine, take out;
(2) all the other the 9 taste crude drugs except the Radix Pulsatillae and the Radix Aucklandiae are placed in marmite, add water, the consumption of water is 2.6-6.5 times (consumption of preferred water is 4 times of the medical material gross weight added) of the medical material gross weight added, and soaks 1-2 hour (preferably soaking 1.5 hours);
(3) medical material that step (2) was soaked first is boiled to boiling with big fire, rear turn of little fire decocts 20-40 minute (preferably, a turn little fire decocts 30 minutes), add water, the consumption of water is 2-5 times (consumption of preferred water is 3 times of the medical material gross weight added) of the medical material gross weight added, then add the Radix Aucklandiae and step (1) the gained Radix Pulsatillae, boil to boiling with big fire, rear turn of little fire decocts 30-50 minute (preferably, a turn little fire decocts 40 minutes), leach medicinal liquid, to obtain final product.
The preparation method of described powder is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 10-30 minute (being preferably soaked in water 20 minutes), drags in basket, add a cover wet cloth profit 3-6 hour (preferably add a cover wet cloth and moisten 4 hours), take out, section, then soak 1-3 hour (preferably soaking 2 hours with wine again) with wine, take out, dry, be ground into fine powder, cross 150-190 mesh sieve (preferred mistake 180 mesh sieve);
(2) all the other crude drug except the Radix Pulsatillae are removed impurity, pulverize respectively and grind to form fine powder, cross 160-200 mesh sieve (preferred mistake 180 mesh sieve);
(3) step (1) and step (2) gained fine powder are fully mixed, sterile packaged, often wrap 4 grams.
The preparation method of described thick paste agent is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 10-30 minute (being preferably soaked in water 20 minutes), drag in basket, add a cover wet cloth profit 3-6 hour (preferably add a cover wet cloth and moisten 4 hours), take out, section, then soak 1-3 hour (preferably soaking 2 hours with wine again) with wine, take out;
(2) all the other the 9 taste crude drugs except the Radix Pulsatillae and the Radix Aucklandiae are placed in marmite, add water, the consumption of water is 2.6-6.5 times (consumption of preferred water is 4 times of the medical material gross weight added) of the medical material gross weight added, and soaks 1-2 hour (preferably soaking 1.5 hours);
(3) medical material that step (2) was soaked first is boiled to boiling with big fire, rear turn of little fire decocts 20-40 minute (preferably, a turn little fire decocts 30 minutes), add water, the consumption of water is 2-5 times (consumption of preferred water is 3 times of the medical material gross weight added) of the medical material gross weight added, then the Radix Aucklandiae and step (1) the gained Radix Pulsatillae is added, boil to boiling with big fire, rear turn of little fire decocts 30-50 minute (preferably, a turn little fire decocts 40 minutes), leaches medicinal liquid;
(4) reduced pressure by step (3) gained medicinal liquid, to be concentrated into relative density be the preferred relative density of 1.15-1.35(is 1.25) clear paste, then add adjuvant and mix well, seal and get final product in dress aseptic bottle.
The preparation method of described pill is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 10-30 minute (being preferably soaked in water 20 minutes), drags in basket, add a cover wet cloth profit 3-6 hour (preferably add a cover wet cloth and moisten 4 hours), take out, section, then soak 1-3 hour (preferably soaking 2 hours with wine again) with wine, take out, dry, be ground into fine powder, cross 120-150 mesh sieve (preferred mistake 140 mesh sieve);
(2) all the other crude drug except the Radix Pulsatillae are removed impurity, after drying, be mixed together by these medicines and be ground into fine powder, 120-150 mesh sieve (preferred mistake 140 mesh sieve), then fully mixes with step (1) gained fine powder;
(3) refined honey is joined in step (2) gained mixing fine powder, the weight of refined honey is 0.8-1.6 times (weight of preferred refined honey is 1.2 times of medicine gross weight) of medicine gross weight, make little pill, the particle diameter of little pill is the particle diameter of the preferred little pill of 2-6mm(is 4mm).
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Rhizoma Coptidis: another name: taste company, Rhizoma Coptidis, Rhizoma Coptidis, base is former: be the dry rhizome of ranunculaceae plant Rhizoma Coptidis, Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall.The property of medicine: bitter, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.
The Radix Pulsatillae: base is former: this product is the dry root of the ranunculaceae plant Radix Pulsatillae.The property of medicine: bitter, cold.Return stomach, large intestine channel.Function cures mainly: heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.For toxic-heat and blood stasis, pudendal pruritus leukorrhagia, amebic dysentery.
The Radix Aucklandiae: base is former: be the dry root of the feverfew Radix Aucklandiae.The property of medicine: pungent, bitter, temperature.Return spleen, stomach, large intestine, three burnt, gallbladder meridians.Function cures mainly: promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.For breast gastral cavity distending pain, heavy after dysentery, food stagnation does not disappear, anorexia.The real intestinal antidiarrheal of Radix Aucklandiae (roasted).For stomachache of having loose bowels.
Herba Polygoni Capitati: base is former: be the herb of polygonaceae plant Herba Polygoni Capitati.Chemical composition of Chinese materia medica: Herba Polygoni Capitati herb contains benzaldehyde, acetic acid, 24-hydroxyl lignocerane-3-ketone, 29-hydroxyl nonacosane-3-ketone, cupreol, gallic acid." Guangxi Chinese herbal medicine ": " bitter in the mouth, pungent, property is put down, nontoxic." function cures mainly: removing toxic substances, dissipating blood stasis, inducing diuresis for treating stranguria syndrome.Control dysentery, pyelitis, cystitis, lithangiuria, rheumatalgia, traumatic injury, skin infection eczema.
Ramulus et Folium Bischofiae Javanicae: base is former: be root, the bark of euphorbia plant Ramulus et Folium Bischofiae Javanicae.Chemical composition of Chinese materia medica: stem is containing cupreol, freidelin, epifriedelanol, freidelin alcohol and cupreol-β-glycoside.Seed oil-containing 25.5%, the iodine number 159.0 of oil, saponification number 194.5.Fatty acid forms: myristic acid 0.3%, Palmic acid 10.5%, stearic acid 5.0%, hexadecenoic acid 0.2%, oleic acid 23.9%, linoleic acid 23.4%, linolenic acid 36.7%.The property of medicine: pungent, puckery, cool.GUIXIN warp.Function cures mainly: expelling wind and removing dampness, blood stasis dispelling removing food stagnancy.Main rheumatic ostalgia, dysphagic, regurgitation, dysentery.
The Radix Astragali: base is former: be the dry root of leguminous plant Radix Astagali or Radix Astragali.The property of medicine: sweet, temperature.Return lung, spleen channel.Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst, chronic nephritis proteinuria, diabetes.
Radix Streptocauli Griffithii: base is former: for dicotyledon medicine asclepiadaceae plant horse connects the root of saddle.The property of medicine: bitter, micro-sweet, cool.Return spleen, kidney, urinary bladder channel.Function cures mainly: heat-clearing and toxic substances removing, eliminating stasis to stop pain.For cold, fever, dysentery, stomachache, stomachache, traumatic injury stasis of blood pain, venom.
Ramulus Cinnamomi: base is former: be the twig of canella Cortex Cinnamomi.Ramulus Cinnamomi is containing volatile oil 0.69%, and in oil, main component is cinnamic aldehyde 64.75%, also has benzyl benzoate, cinnamyl acetate, β-cadinene, Chang Pu alkene, coumarin etc.The property of medicine: acrid, sweet, warm.Return bladder, the heart, lung meridian.Function cures mainly: expelling cold and relieving exterior syndrome, promoting the flow of QI-blood by warming the meridian.For activating YANG and prormoting functioning of QI exterior syndrome due to wind-cold, arthralgia due to cold-dampnes, extreme cold of the limbs, amenorrhea dysmenorrhea ， mass in the abdomen lumps, the thoracic obstruction, cardiopalmus, phlegm retention, dysuria.
Herba Portulacae: base is former: be the herb of portulacaceous plant Herba Portulacae.Chemical composition of Chinese materia medica: herb is containing a large amount of norepinephrine and volume potassium salt (comprising potassium nitrate, potassium chloride, potassium sulfate and other potassium salt).Also containing DOPA, dopamine, betanidin, isobetanidin, different Radix Betae glycoside, oxalic acid, malic acid, citric acid, glutamic acid, aspartic acid, alanine and glucose, fructose, sucrose etc.Herb shows alkaloid according to another report, coumarin, flavone, the reaction of cardiotonic glycoside and anthracene glycoside.And containing a large amount of poly-omega-3 unsaturated fatty acids.The property of medicine: acid, cold.Return large intestine, Liver Channel.Function cures mainly: heat-clearing and toxic substances removing, cooling blood for hemostasis.For toxic-heat and blood stasis, carbuncle furuncle, eczema, erysipelas, snake bite and insect sting, has blood in stool, hemorrhoidal bleeding, metrostaxis.
Casuarina equisetifolia L.: base is former: be young browse or the bark of Casuarinaceae Casuarina plant Casuarina equisetifolia L..Composition: leaf is containing triterpene, and branch and leaf are containing triterpenoid compound, and heartwood is also containing phenol and tannin composition.Function cures mainly: " Taiwan medicinal plants will ": " (India) bark is the excellent astringent of chronic diarrhea and dysentery, and preserved material is antasthenic; (Malaysia) bark controls diarrhoea and dysentery, washing beriberi, and colic controlled by decoct; The heavy dose of decoction of (Philippine) bark is emmenagogue and oxytocic." " twig decocts branch, washing toxic swelling, pastes forehead headache.”
Radix Thyrocarpi sampsonii: base is former: be the herb of Boraginaceae Radix Thyrocarpi sampsonii platymiscium Radix Thyrocarpi sampsonii.The property of medicine: bitter, cool.Function cures mainly: clearing heat, releasing toxin, removing swelling.Cure mainly carbuncle, furuncle, have sore throat, have loose bowels, dysentery.
Chronic dysentery invigorating the spleen and benefiting QI preparation recipe science provided by the invention, the preparation method of various dosage form is simple, products obtained therefrom taking convenience.In addition, excellent results of the present invention also shows:
1, raw material is cheap and easy to get, and treatment cost is low;
2, safe and reliable, have no side effect;
3, short treating period, instant effect;
4, evident in efficacy, without recurrence;
5, there is effect of heat-clearing and toxic substances removing, invigorating the spleen and benefiting QI, eliminating pathogenic heat from blood to cure dysentery.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1chronic dysentery invigorating the spleen and benefiting QI preparation, the primary raw material medicine getting following weight is prepared from: Rhizoma Coptidis 3g, Radix Pulsatillae 10g, Radix Aucklandiae 5g, Herba Polygoni Capitati 15g, Ramulus et Folium Bischofiae Javanicae 6g, Radix Astragali 12g, Radix Streptocauli Griffithii 6g, Ramulus Cinnamomi 8g, Herba Portulacae 18g, Casuarina equisetifolia L. 6g, Radix Thyrocarpi sampsonii 6g.
The preparation method of chronic dysentery invigorating the spleen and benefiting QI preparation decoction is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 10 minutes, drag in basket, add a cover wet cloth and moisten 3 hours, take out, section, then soak 1 hour with wine, take out;
(2) all the other the 9 taste crude drugs except the Radix Pulsatillae and the Radix Aucklandiae are placed in marmite, add water, the consumption of water is 2.6 times of the medical material gross weight added, and soaks 1 hour;
(3) medical material that step (2) was soaked first is boiled to boiling with big fire, rear turn of little fire decocts 20 minutes, add water, the consumption of water is 2 times of the medical material gross weight added, then add the Radix Aucklandiae and step (1) the gained Radix Pulsatillae, boil to boiling with big fire, rear turn of little fire decocts 30 minutes, leach medicinal liquid, to obtain final product.
Decoction instructions of taking of the present invention: every day twice, each 260mL(is warm).
embodiment 2chronic dysentery invigorating the spleen and benefiting QI preparation, the primary raw material medicine getting following weight is prepared from: Rhizoma Coptidis 6g, Radix Pulsatillae 20g, Radix Aucklandiae 15g, Herba Polygoni Capitati 25g, Ramulus et Folium Bischofiae Javanicae 12g, Radix Astragali 20g, Radix Streptocauli Griffithii 10g, Ramulus Cinnamomi 15g, Herba Portulacae 40g, Casuarina equisetifolia L. 12g, Radix Thyrocarpi sampsonii 15g.
The preparation method of chronic dysentery invigorating the spleen and benefiting QI preparation powder is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 20 minutes, drag in basket, add a cover wet cloth and moisten 4 hours, take out, section, then soak 2 hours with wine, take out, dry, be ground into fine powder, cross 180 mesh sieves;
(2) all the other crude drug except the Radix Pulsatillae are removed impurity, pulverize respectively and grind to form fine powder, cross 180 mesh sieves;
(3) step (1) and step (2) gained fine powder are fully mixed, sterile packaged, often wrap 4 grams.
model case one:king XX, female, 48 years old.Suffer from chronic dysentery over 2 years, dysentery does not heal for a long time, time when sending out only, take Chinese and western drugs repeatly and fail radical cure.Slightly eat greasy food and namely feel tenesmus, stomachache, stool band pus and blood, body volume is thought sleeping, pale tongue with greasy fur, soft pulse.Take the present embodiment gained chronic dysentery invigorating the spleen and benefiting QI preparation powder, every day twice, each 4g, taken with boiled water.Take medicine and fully recover for 5th, recur again at the end of 2 so far.
embodiment 3chronic dysentery invigorating the spleen and benefiting QI preparation, the primary raw material medicine getting following weight is prepared from: Rhizoma Coptidis 3.5g, Radix Pulsatillae 12g, Radix Aucklandiae 7g, Herba Polygoni Capitati 18g, Ramulus et Folium Bischofiae Javanicae 8g, Radix Astragali 14g, Radix Streptocauli Griffithii 7g, Ramulus Cinnamomi 9g, Herba Portulacae 25g, Casuarina equisetifolia L. 8g, Radix Thyrocarpi sampsonii 9g.
The preparation method of chronic dysentery invigorating the spleen and benefiting QI preparation thick paste agent is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 20 minutes, drag in basket, add a cover wet cloth and moisten 4 hours, take out, section, then soak 2 hours with wine, take out;
(2) all the other the 9 taste crude drugs except the Radix Pulsatillae and the Radix Aucklandiae are placed in marmite, add water, the consumption of water is 4 times of the medical material gross weight added, and soaks 1.5 hours;
(3) medical material that step (2) was soaked first is boiled to boiling with big fire, rear turn of little fire decocts 30 minutes, add water, the consumption of water is 3 times of the medical material gross weight added, then the Radix Aucklandiae and step (1) the gained Radix Pulsatillae is added, boil to boiling with big fire, rear turn of little fire decocts 40 minutes, leaches medicinal liquid;
(4) step (3) gained medicinal liquid is reduced pressure, be concentrated into the clear paste that relative density is 1.25, then add adjuvant and mix well, seal and get final product in dress aseptic bottle.
model case two:lee XX, man, 45 years old.Chronic dysentery is shown effect more than 3 years often, in many ways seeks medical advice and fails to effect a radical cure.Now defecate every day about 6 times, be mingled with red white gluing just and freeze, the few viscous of amount, tenesmus, few abdomen dull pain, xerostomia, shallow complexion shades, look asthenia, feverish sensation over the palm, red tongue with yellowish and greasy fur, thready and rapid pulse.Take the agent of the present embodiment gained chronic dysentery invigorating the spleen and benefiting QI preparation thick paste, every day three times, each 20 grams.Take two days, each stool day 2 times, red white gluing freezes minimizing, and the comparatively front smooth profit of defecation, the symptoms such as tenesmus, few abdomen dull pain disappear substantially.Continue to take two days, stool day 1 time, just, red white sticky freezing removes, and all transference cures, disease is fully recovered.
embodiment 4chronic dysentery invigorating the spleen and benefiting QI preparation, the primary raw material medicine getting following weight is prepared from: Rhizoma Coptidis 5g, Radix Pulsatillae 16g, Radix Aucklandiae 12g, Herba Polygoni Capitati 20g, Ramulus et Folium Bischofiae Javanicae 11g, Radix Astragali 18g, Radix Streptocauli Griffithii 9g, Ramulus Cinnamomi 11g, Herba Portulacae 35g, Casuarina equisetifolia L. 11g, Radix Thyrocarpi sampsonii 13g.
The preparation method of chronic dysentery invigorating the spleen and benefiting QI preparation pill is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 20 minutes, drag in basket, add a cover wet cloth and moisten 4 hours, take out, section, then soak 2 hours with wine, take out, dry, be ground into fine powder, cross 140 mesh sieves;
(2) all the other crude drug except the Radix Pulsatillae are removed impurity, after drying, these medicines are mixed together and are ground into fine powder, cross 140 mesh sieves, then fully mix with step (1) gained fine powder;
(3) joined by refined honey in step (2) gained mixing fine powder, the weight of refined honey is 1.2 times of medicine gross weight, makes little pill, and the particle diameter of little pill is 4mm.
model case three:liu XX, man, 50 years old.Because diet causes acute dysentery accidentally before 2 years, because treatment is thorough, only show mucus loose stool day for several times when sending out time so far still, rectal tenesmus, shortness of breath and fatigue, anorexia, abdominal distention, tingle during left lower quadrant, the gloomy then aggravation of emotion, dimly pale tongue, white and thin fur, stringy and thready pulse, is diagnosed as chronic dysentery.Take the present embodiment gained chronic dysentery invigorating the spleen and benefiting QI preparation pill, every day three times, each 10.Take 4 days, sick announcement is fully recovered.Follow up a case by regular visits to 2 years, disease is not sent out again.
embodiment 5chronic dysentery invigorating the spleen and benefiting QI preparation, the primary raw material medicine getting following weight is prepared from: Rhizoma Coptidis 4g, Radix Pulsatillae 14g, Radix Aucklandiae 9g, Herba Polygoni Capitati 19g, Ramulus et Folium Bischofiae Javanicae 10g, Radix Astragali 16g, Radix Streptocauli Griffithii 8g, Ramulus Cinnamomi 10g, Herba Portulacae 28g, Casuarina equisetifolia L. 9g, Radix Thyrocarpi sampsonii 12g.
The preparation method of chronic dysentery invigorating the spleen and benefiting QI preparation decoction is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 20 minutes, drag in basket, add a cover wet cloth and moisten 4 hours, take out, section, then soak 2 hours with wine, take out;
(2) all the other the 9 taste crude drugs except the Radix Pulsatillae and the Radix Aucklandiae are placed in marmite, add water, the consumption of water is 4 times of the medical material gross weight added, and soaks 1.5 hours;
(3) medical material that step (2) was soaked first is boiled to boiling with big fire, rear turn of little fire decocts 30 minutes, add water, the consumption of water is 3 times of the medical material gross weight added, then add the Radix Aucklandiae and step (1) the gained Radix Pulsatillae, boil to boiling with big fire, rear turn of little fire decocts 40 minutes, leach medicinal liquid, to obtain final product.
test example 1:in order to verify the drug effect of embodiment 5 gained chronic dysentery invigorating the spleen and benefiting QI preparation decoction, We conducted contrast test.Experiment screening chronic dysentery patient 268 people, is divided into matched group and experimental group randomly, and every panel size is identical, is respectively 134 people.Experimental group: take embodiment 5 gained chronic dysentery invigorating the spleen and benefiting QI preparation decoction, instructions of taking: every day twice, each 260mL(decoction being taken warmly).Matched group: the medicine using the conventional therapy chronic dysenterys such as Ceftriaxone, cefobid, amikacin pin.Curative effect situation criterion: cure: clinical symptoms, sign disappear, and the lab testing such as stool routine examination, routine blood test is often all become a full member; Effective: clinical symptoms, sign disappear substantially, the index such as routine blood test, stool routine examination major part is normal; Take a turn for the better: clinical symptoms, sign take a turn for the better, and routine blood test, stool routine examination part are normal; Invalid: clinical symptoms and sign, blood and stool routine examination check without improving.Total effectively comprising cures and effective.Treat result after 7 days as shown in the table:
Table 1: embodiment 5 gained chronic dysentery invigorating the spleen and benefiting QI preparation decoction compliance test result
Therapeutic effect: cure 88 examples (65.67%), effective 45 examples (33.58%), 1 example that takes a turn for the better (0.75%), total effective rate 99.25%.Successful is better than matched group.
The present invention selects Rhizoma Coptidis, the Radix Pulsatillae, the Radix Aucklandiae, Herba Polygoni Capitati etc. to carry out compatibility, makes these medicines produce synergism, more effectively can treat chronic dysentery.In side, Rhizoma Coptidis bitter cold has the effect of heat clearing and damp drying, consolidating YIN eliminating fire and detoxication.Radix Pulsatillae heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.Radix Aucklandiae promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.Herba Polygoni Capitati detoxifies, dissipating blood stasis, inducing diuresis for treating stranguria syndrome.Ramulus et Folium Bischofiae Javanicae expelling wind and removing dampness, blood stasis dispelling removing food stagnancy.Radix Astragali invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Radix Streptocauli Griffithii heat-clearing and toxic substances removing, eliminating stasis to stop pain.Ramulus Cinnamomi expelling cold and relieving exterior syndrome, promoting the flow of QI-blood by warming the meridian.Herba Portulacae heat-clearing and toxic substances removing, cooling blood for hemostasis.Casuarina equisetifolia L. is the excellent astringent of chronic diarrhea and dysentery.Radix Thyrocarpi sampsonii clearing heat, releasing toxin, removing swelling.All medicine compatibilities, play the effect of heat-clearing and toxic substances removing, invigorating the spleen and benefiting QI, eliminating pathogenic heat from blood to cure dysentery altogether.Chronic dysentery invigorating the spleen and benefiting QI preparation of the present invention is evident in efficacy.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. chronic dysentery invigorating the spleen and benefiting QI preparation, is characterized in that, takes off the primary raw material medicine stating weight proportion and is prepared from: Rhizoma Coptidis 3-6, Radix Pulsatillae 10-20, Radix Aucklandiae 5-15, Herba Polygoni Capitati 15-25, Ramulus et Folium Bischofiae Javanicae 6-12, Radix Astragali 12-20, Radix Streptocauli Griffithii 6-10, Ramulus Cinnamomi 8-15, Herba Portulacae 18-40, Casuarina equisetifolia L. 6-12, Radix Thyrocarpi sampsonii 6-15.
2. chronic dysentery invigorating the spleen and benefiting QI preparation according to claim 1, is characterized in that, takes off the primary raw material medicine stating weight proportion and is prepared from: Rhizoma Coptidis 3.5-5, Radix Pulsatillae 12-16, Radix Aucklandiae 7-12, Herba Polygoni Capitati 18-20, Ramulus et Folium Bischofiae Javanicae 8-11, Radix Astragali 14-18, Radix Streptocauli Griffithii 7-9, Ramulus Cinnamomi 9-11, Herba Portulacae 25-35, Casuarina equisetifolia L. 8-11, Radix Thyrocarpi sampsonii 9-13.
3. chronic dysentery invigorating the spleen and benefiting QI preparation according to claim 1, is characterized in that, takes off the primary raw material medicine stating weight proportion and is prepared from: Rhizoma Coptidis 4, the Radix Pulsatillae 14, the Radix Aucklandiae 9, Herba Polygoni Capitati 19, Ramulus et Folium Bischofiae Javanicae 10, the Radix Astragali 16, Radix Streptocauli Griffithii 8, Ramulus Cinnamomi 10, Herba Portulacae 28, Casuarina equisetifolia L. 9, Radix Thyrocarpi sampsonii 12.
4., according to the arbitrary described chronic dysentery invigorating the spleen and benefiting QI preparation of claim 1-3, it is characterized in that, this chronic dysentery invigorating the spleen and benefiting QI preparation is made pharmaceutically acceptable decoction, powder, thick paste agent and pill.
5. the preparation method of chronic dysentery invigorating the spleen and benefiting QI preparation according to claim 4, it is characterized in that, the preparation method of described decoction is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 10-30 minute (being preferably soaked in water 20 minutes), drag in basket, add a cover wet cloth profit 3-6 hour (preferably add a cover wet cloth and moisten 4 hours), take out, section, then soak 1-3 hour (preferably soaking 2 hours with wine again) with wine, take out;
(2) all the other the 9 taste crude drugs except the Radix Pulsatillae and the Radix Aucklandiae are placed in marmite, add water, the consumption of water is 2.6-6.5 times (consumption of preferred water is 4 times of the medical material gross weight added) of the medical material gross weight added, and soaks 1-2 hour (preferably soaking 1.5 hours);
(3) medical material that step (2) was soaked first is boiled to boiling with big fire, rear turn of little fire decocts 20-40 minute (preferably, a turn little fire decocts 30 minutes), add water, the consumption of water is 2-5 times (consumption of preferred water is 3 times of the medical material gross weight added) of the medical material gross weight added, then add the Radix Aucklandiae and step (1) the gained Radix Pulsatillae, boil to boiling with big fire, rear turn of little fire decocts 30-50 minute (preferably, a turn little fire decocts 40 minutes), leach medicinal liquid, to obtain final product.
6. the preparation method of chronic dysentery invigorating the spleen and benefiting QI preparation according to claim 4, it is characterized in that, the preparation method of described powder is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 10-30 minute (being preferably soaked in water 20 minutes), drags in basket, add a cover wet cloth profit 3-6 hour (preferably add a cover wet cloth and moisten 4 hours), take out, section, then soak 1-3 hour (preferably soaking 2 hours with wine again) with wine, take out, dry, be ground into fine powder, cross 150-190 mesh sieve (preferred mistake 180 mesh sieve);
(2) all the other crude drug except the Radix Pulsatillae are removed impurity, pulverize respectively and grind to form fine powder, cross 160-200 mesh sieve (preferred mistake 180 mesh sieve);
(3) step (1) and step (2) gained fine powder are fully mixed, sterile packaged, often wrap 4 grams.
7. the preparation method of chronic dysentery invigorating the spleen and benefiting QI preparation according to claim 4, is characterized in that, the preparation method of described thick paste agent is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 10-30 minute (being preferably soaked in water 20 minutes), drag in basket, add a cover wet cloth profit 3-6 hour (preferably add a cover wet cloth and moisten 4 hours), take out, section, then soak 1-3 hour (preferably soaking 2 hours with wine again) with wine, take out;
(2) all the other the 9 taste crude drugs except the Radix Pulsatillae and the Radix Aucklandiae are placed in marmite, add water, the consumption of water is 2.6-6.5 times (consumption of preferred water is 4 times of the medical material gross weight added) of the medical material gross weight added, and soaks 1-2 hour (preferably soaking 1.5 hours);
(3) medical material that step (2) was soaked first is boiled to boiling with big fire, rear turn of little fire decocts 20-40 minute (preferably, a turn little fire decocts 30 minutes), add water, the consumption of water is 2-5 times (consumption of preferred water is 3 times of the medical material gross weight added) of the medical material gross weight added, then the Radix Aucklandiae and step (1) the gained Radix Pulsatillae is added, boil to boiling with big fire, rear turn of little fire decocts 30-50 minute (preferably, a turn little fire decocts 40 minutes), leaches medicinal liquid;
(4) reduced pressure by step (3) gained medicinal liquid, to be concentrated into relative density be the preferred relative density of 1.15-1.35(is 1.25) clear paste, then add adjuvant and mix well, seal and get final product in dress aseptic bottle.
8. the preparation method of chronic dysentery invigorating the spleen and benefiting QI preparation according to claim 4, it is characterized in that, the preparation method of described pill is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 10-30 minute (being preferably soaked in water 20 minutes), drags in basket, add a cover wet cloth profit 3-6 hour (preferably add a cover wet cloth and moisten 4 hours), take out, section, then soak 1-3 hour (preferably soaking 2 hours with wine again) with wine, take out, dry, be ground into fine powder, cross 120-150 mesh sieve (preferred mistake 140 mesh sieve);
(2) all the other crude drug except the Radix Pulsatillae are removed impurity, after drying, these medicines be mixed together and be ground into fine powder, sieving, then fully mixing with step (1) gained fine powder;
(3) joined by refined honey in step (2) gained mixing fine powder, the weight of refined honey is 0.8-1.6 times (weight of preferred refined honey is 1.2 times of medicine gross weight) of medicine gross weight, makes little pill.
9. the preparation method of chronic dysentery invigorating the spleen and benefiting QI preparation pill according to claim 8, is characterized in that, crosses 120-150 mesh sieve (preferred mistake 140 mesh sieve) in step (2).
10. the preparation method of chronic dysentery invigorating the spleen and benefiting QI preparation pill according to claim 8, is characterized in that, the particle diameter of step (3) medium and small pill is the particle diameter of the preferred little pill of 2-6mm(is 4mm).
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| CN201610178218.5A Division CN105726679A (en) | 2014-10-28 | 2014-10-28 | Spleen strengthening and qi replenishing paste for treating chronic dysentery |
| CN201610178219.XA Division CN105770047A (en) | 2014-10-28 | 2014-10-28 | Medicinal power capable of invigorating spleen and supplementing qi for treating chronic diarrhea |
| CN201610178217.0A Division CN105726678A (en) | 2014-10-28 | 2014-10-28 | Spleen strengthening and qi replenishing preparation for treating chronic dysentery |
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| CN104906266A (en) * | 2015-06-05 | 2015-09-16 | 海南制药厂有限公司 | Drug for resisting Coxsackie virus and preparing method and application thereof |
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| WO2017020861A1 (en) * | 2015-08-05 | 2017-02-09 | 浙江众康药业有限公司 | Application of polygonum capitatum composition in resisting helicobacter pylori |
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