CN103520686A - Medicine for curing diarrhea caused by acquired immune deficiency syndrome - Google Patents
Medicine for curing diarrhea caused by acquired immune deficiency syndrome Download PDFInfo
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Abstract
The invention discloses a medicine for curing diarrhea caused by acquired immune deficiency syndrome. The medicine comprises the following raw materials in parts by weight: 10-30 parts of codonopsis pilosula, 10-25 parts of rhizoma atractylodis, 15-40 parts of rhizoma atractylodis macrocephalae, 5-15 parts of poria cocos, 10-20 parts of hyacinth bean, 10-20 parts of baked ginger, 20-30 parts of agastache rugosus, 10-20 parts of fructus psoraleae, 10-20 parts of myristica fragrans, 15-30 parts of the root of kudzu vine, 15-40 parts of the root of Chinese pulsatilla, and 10-20 parts of processed radix aconiti lateralis. The medicine can be used for curing diarrhea caused by acquired immune deficiency syndrome, so as to adjust the function of intestines and stomach of a patient to be normal, recover the appetite of the patient to be normal, and improve the digestion and immunity.
Description
Technical field
The present invention relates to a kind of medicine that is used for the treatment of acquired immune deficiency syndrome (AIDS), especially for the medicine of the diarrhoea that causes for the treatment of acquired immune deficiency syndrome (AIDS), and relate to the production method of this medicine.
Background technology
Acquired immune deficiency syndrome (AIDS), i.e. acquired immune deficiency syndrome (AIDS), English name Acquired Immune Deficiency Syndrome, AIDS.The mankind because cause immunodeficiency after infecting HIV (human immunodeficiency virus) (Human Immunodeficiency Virus, HIV), concurrent a series of opportunistic infection and tumor, severe patient can cause dead syndrome.At present, acquired immune deficiency syndrome (AIDS) has become the public health problem of serious threat people of the world health.Nineteen eighty-three, the mankind find HIV first.At present, acquired immune deficiency syndrome (AIDS) becomes a kind of controlled chronic disease from a kind of fatal disease.HAART full name highly active antiretroviral therapy, HAART, is commonly called as HAART.Being to be proposed in 1996 by scientist Chinese descendant in America He great Yi, is to be combined and made for treating the method for acquired immune deficiency syndrome (AIDS) by more than three kinds or three kinds antiviral drugs, is the most basic Therapeutic Method of acquired immune deficiency syndrome (AIDS).Although combine and make can kill HIV (human immunodeficiency virus) for treating acquired immune deficiency syndrome (AIDS) by more than three kinds or three kinds antiviral drugs, suppress to greatest extent copying of virus, Save and restore immunologic function, reduce case fatality rate and the diseases related sickness rate of HIV, but side effect is simultaneously also very important, as: cause gastrointestinal upset, anorexia, vomiting, diarrhoea, the particularly bad crowd of gastrointestinal function, the untoward reaction phenomenon of this respect is more obvious.And gastrointestinal upset will reduce absorption of human body nutrient substance, greatly reduce to support antiviral ability, particularly diarrhoea, can make patient body weaker, and immunity is low, finally can cause a series of immunity syndrome of falling.How to improve HIV sufferers loss of appetite, the symptom such as diarrhoea particularly, existing people has made research in this respect.Chinese Patent Application No. is that the patent of invention of 200410030849.X discloses a kind of Chinese medicine preparation and processing method thereof for the treatment of acquired immune deficiency syndrome (AIDS), described medicament is prepared from by weight by Herba Erodii, the Radix Astragali, Herba Solani Nigri, Flos Lonicerae, Flos Bombacis Malabarici, Fructus Chebulae, Herba Hedyotidis Diffusae, Pericarpium Granati, Radix Oryzae Glutinosae, Pedicellus et Pericarpium Trapae raw material, the effect with heat-clearing and toxic substances removing, activating blood circulation and supplementing qi, can improve patient's power, the symptoms such as alopecia, loss of appetite and diarrhoea, improve movable function situation.Chinese Patent Application No. is that 200710111725.8 patent of invention discloses a kind of Chinese patent medicine for the treatment of acquired immune deficiency syndrome (AIDS), Cortex Dictamni, Radix Glycyrrhizae, the Radix Paeoniae Alba, the Radix Astragali and WUGENSHENG, consists of, and medication can be eliminated stomachache, symptom of diarrhea in three days.Chinese Patent Application No. is the Chinese medicine product that 02145646.1 patent of invention discloses one group for the treatment of acquired immune deficiency syndrome (AIDS) high heat, diarrhoea, the ingredients for the treatment of diarrhoea is: Radix Et Rhizoma Rhei 40-50, Radix Ginseng 30-40, Rhizoma Zingiberis 50-60, Radix Aconiti Lateralis Preparata 20, Radix Glycyrrhizae 20, the Radix Paeoniae Alba 30, roasted RADIX PUERARIAE 20-30, Radix Sophorae Flavescentis 20-30, Herba Asari 5-10, Rhizoma Acori Graminei 15-20, Rhizoma Cimicifugae 15-20.
Summary of the invention
The object of this invention is to provide a kind of medicine that can treat the symptom of diarrhea that acquired immune deficiency syndrome (AIDS) causes.
Technical scheme of the present invention is:
The medicine for the treatment of acquired immune deficiency syndrome (AIDS) diarrhoea, the raw material weight umber of its composition is as follows: Radix Codonopsis 10～30; Rhizoma Atractylodis 10～25; The Rhizoma Atractylodis Macrocephalae 15～40; Poria 5～15; Seem Lablab Album 10～20; Rhizoma Zingiberis Preparatum 10～20; Herba Pogostemonis 20～30; Fructus Psoraleae 10～20; Semen Myristicae 10～20; Radix Puerariae 15～30; The Radix Pulsatillae 15～40; Radix Aconiti Lateralis Preparata 10～20.
Described Radix Codonopsis, another name: Shangdang Radix Ginseng, Radix Saposhnikoviae Radix Codonopsis, Sphallerocarpus gracilis, preventing lanceolata, upper Radix Codonopsis, SHITOUSEN, middle Ganoderma ,Huang party, Codonopsis plant, campanulaceae, English name: Root of Pilose Asiabell, Pilose Asiabell Root Moderate Asiabell Root Szechwon Tangshen Root, Latin formal name used at school: Root of Pilose Asiabell, meridian distribution of property and flavor: property is flat, sweet in the mouth, micro-acid.Return spleen, lung meridian.There is invigorating the spleen and replenishing QI, the effect of spleen invigorating lung benefiting.Cure mainly weakness of the spleen and stomach, anorexia and loose stool, fatigue and weakness, the deficiency of the lung is breathed with cough, the lazy speech of breathing hard, spontaneous perspiration, blood deficiency and yellow complexion, thirsty.For deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst etc." Bencao Congxin " recorded: " invigorating the spleen and replenishing QI and taste, relieving thirst and restlessness.A little less than middle feeble QI, in order to adjust, mend, very smooth and proper.”。Radix Codonopsis is the key medicine of air making-up and spleen enlivening, and contained saponin, inulin, Alkaloid, starch etc. have strong effect in various degree to the many internal organs of human body, can improve the adaptability of human body.There is antiulcer, can increase intestinal tension force, regulate stomach motion, in the intestines and stomach coordinating preparation, reuse the intestines and stomach regulation of mental activities agent of Radix Codonopsis to chronic diarrhea, ulcerative colitis, antral gastritis, chronic atrophic gastritis etc. quite have effect.
Described Rhizoma Atractylodis, are the dry rhizome of Compositae [WTBX plant Rhizoma Atractylodis (Latin formal name used at school Atractylodes lancea), and Rhizoma Atractylodis are pungent, bitter, temperature.Return spleen, stomach, Liver Channel, cure mainly: the transporting imbalance that the spleen being blocked by dampness causes, inappetence, vomiting is unhappy, and abdominal distention is had loose bowels, arthralgia.Rhizoma Atractylodis can with Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae compatibility, with dampness activating the spleen, relieving QI stagnancy in the stomach; If the spleen being blocked by dampness, clear QI being mixed up with turbid QI, loose stool and diarrhea, oliguria person, can be equal to use with Cortex Magnoliae Officinalis, Poria, Rhizoma Alismatis, with the spleen strengthening and damp drying, diuresis and real stool.
The described Rhizoma Atractylodis Macrocephalae, another name: Rhizoma Atractylodis Macrocephalae, winter art, the winter Rhizoma Atractylodis Macrocephalae, Latin Rhizoma Atractylodis Macrocephalae, English by name Largehead Atractylodes Rh, the effects such as the Rhizoma Atractylodis Macrocephalae has the gastrointestinal motility of adjustment function, antiulcer, protects the liver, enhancing human body immunity function, anti-stress, enhancing hemopoietic function, antioxidation, slow down aging, blood sugar lowering, anticoagulation, antitumor." medicine origin " is recorded: " dehumidifying benefit is dry, and middle QI invigorating, and warming middle-JIAO goes to wet in taste, and except gastric heat, strong taste, enter diet, quench the thirst, antiabortive." modern pharmacological research confirmation, Rhizoma Atractylodis Macrocephalae decocting liquid has the effect of the HIV (human immunodeficiency virus) of inhibition.The Rhizoma Atractylodis Macrocephalae is for deficiency of spleen-QI and stomach-QI, and transporting is unable, anorexia and loose stool, distension and fullness in the abdomen, the cards such as the soft Mental fatigue of limb.The Rhizoma Atractylodis Macrocephalae has the effect of air making-up and spleen enlivening, treatment deficiency-weakness of spleen-QI, and lack of appetite Mental fatigue, Chang Peiwu Radix Ginseng or Radix Codonopsis, Poria, Radix Glycyrrhizae are equal to use, with replenishing QI to invigorate the spleen.
Described Poria, is commonly called as Poria, Song Ling, Poria, and the dry sclerotia for On Polyporaceae Poria Poria cocos (Schw.) Wolf, colonizes in the fungi plant on pinaster root, and shape is as Rhizoma Dioscoreae esculentae, crust pitchy, the inside white or pink.Its protozoa is the dry sclerotia of On Polyporaceae Poria, and multiparasitization is in the root of Pinus massoniana Lamb or Pinus densiflora.Originate in the ground such as Yunnan, Anhui, Hubei, Henan, Sichuan.Ancients claim that Poria is " god medicine " at 4 o'clock, because its effect is very extensive, regardless of the four seasons, by it and various compatibility of drugs, no matter cold, temperature, wind, all diseases that wets can be brought into play its unique effects.Poria sweet in the mouth, light, property are flat, be used as medicine there is promoting diuresis to eliminate damp pathogen, the function of strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.
Described Seem Lablab Album is the dry seed of annual plant Seem Lablab Album (Latin formal name used at school Lablab purpureus (Linn.) Sweet).Seem Lablab Album sweet in the mouth enters taste warp, cure mainly spleen invigorating and in, the removing dampness of relieving summer heat.Control heat-damp in summer and vomit and diarrhoea, insufficiency of the spleen vomiting, lack of appetite chronic diarrhea, water retention is quenched one's thirst, leucorrhea with red and white discharge, infantile malnutrition, be spleen reinforcing simply and do not grow greasy, dehumidifying and not dry strong invigorating the spleen for eliminating dampness good medicine.Be usually used in the insufficiency of the spleen fatigue and asthenia having due to wetting, in anorexia and loose stool, have loose bowels, with Radix Ginseng, the same use of the Rhizoma Atractylodis Macrocephalae, to strengthen the power of invigorating the spleen for eliminating dampness.
Described Rhizoma Zingiberis Preparatum is the processed product of the dry rhizome of zingiber Zingiber officinale Rosc., be Rhizoma Zingiberis fry to surperficial duskiness, in be brown color and form.Rhizoma Zingiberis Preparatum nature and flavor are bitter, pungent, warm.The effect with warming spleen and stomach for dispelling cold, warming the meridian for stopping bleeding.The pungent dry property of Rhizoma Zingiberis Preparatum is compared with a little less than Rhizoma Zingiberis, and the power of warming the interior, be not as swift and violent as Rhizoma Zingiberis, relaxes lastingly but act on, and is longer than warming middle-JIAO to relieve pain, antidiarrheal and warming the meridian for stopping bleeding.Can be used for the cold stomachache of the middle deficiency of vital energy, diarrhoea and deficiency and coldness hemorrhage.
Described Herba Pogostemonis is the herb of Labiatae herbaceos perennial Herba Pogostemonis Agastache rugosa (Fisch. et Mey.) O. Ktze.Herba Pogostemonis is for vomitting, have loose bowels etc.If experience foul, the disease had loose bowels of vomiting, can join Folium Perillae, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae and be equal to use; If gastrofrigid vomiting person, Herba Pogostemonis can be joined the Rhizoma Pinelliae with using; As damp and hot person, Herba Pogostemonis can be joined Rhizoma Coptidis, Caulis Bambusae In Taenia; Weakness of the spleen and stomach person, Herba Pogostemonis can be joined Radix Codonopsis, Radix Glycyrrhizae; Vomiting during pregnancy, Herba Pogostemonis can be joined Fructus Amomi with using.Herba Pogostemonis for dampness taste, distension and fullness in the abdomen, hygropyrexia from the beginning of.Herba Pogostemonis is for fever with chills, fever with aversion to cold, chest distress.Compatibility Folium Perillae, Pericarpium Citri Reticulatae.Herba Pogostemonis is for heat-damp in summer disease.It controls heat-damp in summer, though partially cold, partial heat all can apply, clinical often with Herba Eupatorii compatibility with use.Herba Pogostemonis is controlled nasal sinusitis, often can join Fel Sus domestica and be equal to use.
Described Fructus Psoraleae, another name: Hu Semen Allii Tuberosi, the solid fat of mother-in-law, Fructus Psoraleae, Psoralen sparrow hawk, FRUCTUS PSORALEAE, Hu Fructus Psoraleae, Ji Guzi, FRUCTUS PSORALEAE are the fruit of legumes psoraleae Psoralea corylifolia L..Fructus Psoraleae cures mainly reinforcing the kidney and supporting YANG; Helping inspiration to relieve asthma; Warming spleen and stopping diarrha.Main insufficiency of kidney-YANG; Below element deficiency and cold; Chills and pain of the waist and kness; Impotence and seminal emission; Frequent micturition; The enuresis; Failure of the kidney in receiving QI; Dyspnea due to deficiency is more than; Asthenia of both the spleen and kidney; Stool chronic diarrhea.
Described Semen Myristicae is the kernel of myristicaceae plant Semen Myristicae (formal name used at school Myristica fragrans), and Semen Myristicae another name Fructus Amomi Rotundus, flesh fruit, character used in proper names and in rendering some foreign names are arrested and strangled, come directly towards meat, semen myristicae, bundle ground, fiber crops mistake, and Semen Myristicae has the effect of warming middle-JIAO astringing intestine to stop diarrhea, promote qi circulation digestion promoting.Semen Myristicae warming middle-JIAO astringing intestine to stop diarrhea; Promote qi circulation digestion promoting.Cure mainly: diarrhea of deficiency type; Cold-dysentery; Abdominal distention; Lack of appetite vomiting; Dyspepsia does not disappear.The pungent temperature of Semen Myristicae and puckery, enters middle Jiao, can warming the spleen and stomach, and solid large intestine, antidiarrheal dysentery, Semen Myristicae is for treating the key medicine of deficiency and coldness dysentery.Semen Myristicae is controlled chronic diarrhea, the chronic dysentery person of Deficiency and coldness of spleen and stomach, and the medicines such as normal and Cortex Cinnamomi, Rhizoma Zingiberis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Fructus Chebulae are with use; If Semen Myristicae is joined Fructus Psoraleae, Fructus Schisandrae Chinensis, Fructus Evodiae, can control deficiency of spleen-YANG and kidneyYANG, Diarrhoea person.
Described Radix Puerariae is the dry root of legume pueraria lobata Pueraria lobata (Willd.) Ohwi.Radix Puerariae sweet in the mouth cool in nature is pungent, and having induces sweat brings down a fever, and promotes the production of body fluid, the multiple merit such as rash, yang invigorating antidiarrheal.Radix Puerariae compatibility Radix Ginseng, Poria: Radix Puerariae rises the clear sun of taste and antidiarrheal dysentery; Radix Ginseng strongly invigorating primordial QI; Poria spleen invigorating eliminating dampness by diuresis; Three medicines have share the effect of QI invigorating invigorating the spleen to arrest diarrhea, are used for the treatment of diarrhea due to hypofunction of the spleen.
The described Radix Pulsatillae is the dry root of ranunculaceae plant Radix Pulsatillae Pulsatilla chinensis (Bunge) Regel., and another name has how grass, powder silkweed, hoary hair's grass, Lao Gucao, chrysanthemum chrysanthemum Seedling, old man to spend, be always preced with flower, the sub-flower of ram's horn etc.Radix Pulsatillae bitter in the mouth, cold in nature; Return stomach warp, large intestine channel, there is heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, the effect of removing dampness and killing parasites.Cure mainly: pyretic toxicity dysentery, epistaxis, internal hemorrhoid with bleeding, leukorrhagia, pudendal pruritus, carbuncle skin ulcer, scrofula.
Described Radix Aconiti Lateralis Preparata is the processed goods of the daughter root of ranunculaceae plant Aconitum carmichjaelii Debx. Aconitum carmichaeli Debx..Excavate Aconitum carmichjaelii Debx. the first tenday period of a month in the last ten-days period in June to August, removes parent root, fibrous root and silt, practise to claim " mud Radix Aconiti Lateralis Preparata ", through salting, water float, boil, the method such as stir-fry reduces toxicity after concocting, claim " Radix Aconiti Lateralis Preparata ".Radix Aconiti Lateralis Preparata is pungent, sweet, hot greatly; Poisonous.GUIXIN, kidney, spleen channel.Cure mainly recuperating depleted YANG and rescuing the patient from collapse, mend fire supporing yang, by wind-cold damp pathogen.For YANG-depletion collapse, cold extremities faint pulse, sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, arthralgia due to cold-dampnes.
The medicine for the treatment of acquired immune deficiency syndrome (AIDS) diarrhoea of the present invention, by the conventional formulation technique of relevant dosage form, adds appropriate amount of auxiliary materials to make corresponding dosage form, and said medicine can be made oral liquid, granule, capsule, tablet or other pharmaceutically useful dosage form.
The medicine oral liquid production method of above-mentioned treatment acquired immune deficiency syndrome (AIDS) diarrhoea is: get by weight ratio Radix Codonopsis, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Poria, Seem Lablab Album, Rhizoma Zingiberis Preparatum, Herba Pogostemonis, Fructus Psoraleae, Semen Myristicae, Radix Puerariae, the Radix Pulsatillae and Radix Aconiti Lateralis Preparata, by gross weight, add water 5-8 and doubly decoct secondary, each 2 hours, collecting decoction, filter, add adjuvant, make oral liquid.
The medicament capsule production method of above-mentioned treatment acquired immune deficiency syndrome (AIDS) diarrhoea is: get by weight ratio Radix Codonopsis, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Poria, Seem Lablab Album, Rhizoma Zingiberis Preparatum, Herba Pogostemonis, Fructus Psoraleae, Semen Myristicae, Radix Puerariae, the Radix Pulsatillae and Radix Aconiti Lateralis Preparata, by gross weight, add water 5-8 and doubly decoct secondary, each 2 hours, collecting decoction, filtered, be concentrated into relative density and be 1.28～1.30 thick paste, at 80 ℃, dry, pulverize into below fine powder again, add adjuvant, mix, make granulation agent, capsule or tablet.
The medicine for the treatment of acquired immune deficiency syndrome (AIDS) diarrhoea of the present invention is according to " the Treating AIDS with Traditional Chinese Medicine clinical technology scheme (trying) " of the tcm clinical practice feature of acquired immune deficiency syndrome (AIDS) and State Administration of Traditional Chinese Medicine's formulation, in conjunction with factors such as the climate characteristic in Guangxi, constitutive character, environmental factors, staff conditions, a kind of medicine that adapts to the most of infection populations in Guangxi of innovation and creation, has the effect that improves AIDS related complex shape sign.The present invention treats the Chinese medicine preparation of acquired immune deficiency syndrome (AIDS) and the symptom that antiviral combination improves patient's diarrhoea.
The specific embodiment
Embodiment 1
Get by weight ratio 20 parts of 10 parts of Radix Codonopsis, 25 parts of Rhizoma Atractylodis, 40 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts, Poria, 10 parts, Seem Lablab Album, 16 parts of Rhizoma Zingiberis Preparatums, 25 parts of Herba Pogostemoniss, 20 parts of Fructus Psoraleaes, 10 parts of Semen Myristicaes, 15 parts of Radix Puerariaes, 30 parts of the Radix Pulsatillaes and Radix Aconiti Lateralis Preparata, by gross weight, add water 5-8 and doubly decoct secondary, each 2 hours, collecting decoction, filter, add adjuvant, make oral liquid.
Embodiment 2
Get by weight ratio 15 parts of 20 parts of Radix Codonopsis, 20 parts of Rhizoma Atractylodis, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts, Poria, 15 parts, Seem Lablab Album, 20 parts of Rhizoma Zingiberis Preparatums, 20 parts of Herba Pogostemoniss, 15 parts of Fructus Psoraleaes, 20 parts of Semen Myristicaes, 30 parts of Radix Puerariaes, 15 parts of the Radix Pulsatillaes and Radix Aconiti Lateralis Preparata, by gross weight, add water 5-8 and doubly decoct secondary, each 2 hours, collecting decoction, filter, add adjuvant, make oral liquid.
Embodiment 3
Get by weight ratio 10 parts of 30 parts of Radix Codonopsis, 10 parts of Rhizoma Atractylodis, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts, Poria, 20 parts, Seem Lablab Album, 10 parts of Rhizoma Zingiberis Preparatums, 30 parts of Herba Pogostemoniss, 10 parts of Fructus Psoraleaes, 15 parts of Semen Myristicaes, 25 parts of Radix Puerariaes, 40 parts of the Radix Pulsatillaes and Radix Aconiti Lateralis Preparata, by gross weight, add water 5-8 and doubly decoct secondary, each 2 hours, collecting decoction, filtered, be concentrated into relative density and be 1.28～1.30 thick paste, at 80 ℃, dry, pulverize into below fine powder again, add adjuvant, mix, make capsule.
Embodiment 4
Get by weight ratio 10 parts of 15 parts of Radix Codonopsis, 20 parts of Rhizoma Atractylodis, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts, Poria, 10 parts, Seem Lablab Album, 15 parts of Rhizoma Zingiberis Preparatums, 20 parts of Herba Pogostemoniss, 15 parts of Fructus Psoraleaes, 10 parts of Semen Myristicaes, 15 parts of Radix Puerariaes, 20 parts of the Radix Pulsatillaes and Radix Aconiti Lateralis Preparata, by gross weight, add water 5-8 and doubly decoct secondary, each 2 hours, collecting decoction, filtered, be concentrated into relative density and be 1.28～1.30 thick paste, at 80 ℃, dry, pulverize into below fine powder again, add adjuvant, mix, make capsule.
Embodiment 5
Get by weight ratio 12 parts of 25 parts of Radix Codonopsis, 18 parts of Rhizoma Atractylodis, 22 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts, Poria, 17 parts, Seem Lablab Album, 16 parts of Rhizoma Zingiberis Preparatums, 22 parts of Herba Pogostemoniss, 13 parts of Fructus Psoraleaes, 17 parts of Semen Myristicaes, 22 parts of Radix Puerariaes, 25 parts of the Radix Pulsatillaes and Radix Aconiti Lateralis Preparata, by gross weight, add water 5-8 and doubly decoct secondary, each 2 hours, collecting decoction, filter, add adjuvant, granulation agent.
Embodiment 6
Get by weight ratio 10 parts of 11 parts of Radix Codonopsis, 13 parts of Rhizoma Atractylodis, 21 parts of the Rhizoma Atractylodis Macrocephalaes, 17 parts, Poria, 14 parts, Seem Lablab Album, 15 parts of Rhizoma Zingiberis Preparatums, 24 parts of Herba Pogostemoniss, 19 parts of Fructus Psoraleaes, 14 parts of Semen Myristicaes, 18 parts of Radix Puerariaes, 21 parts of the Radix Pulsatillaes and Radix Aconiti Lateralis Preparata, by gross weight, add water 5-8 and doubly decoct secondary, each 2 hours, collecting decoction, filter, be concentrated into relative density and be 1.28～1.30 thick paste, then dry, pulverize into below fine powder at 80 ℃, add adjuvant, mix, tabletting, makes tablet.
clinical trial data
Medicine of the present invention, is in the past few years used oral medicine, tablet, granule, the capsule preparations of embodiment 1-6 to offer the 120 routine patients that Guangxi provincial hospital alleviates the side effect of digestive tract that acquired immune deficiency syndrome (AIDS) antiviral drugs causes, treatment situation is as follows.
One, clinical observation:
1. preparation for treating acquired immune deficiency syndrome (AIDS) clinical symptoms of the present invention, sign situation of change (table 1):
Tcm clinical practice symptom, sign situation of change before and after this compound treatment of table 1
2. the Carlow Paderewski integration situation of change (table 2) of the diarrhoea that preparation for treating acquired immune deficiency syndrome (AIDS) of the present invention causes:
Carlow Paderewski integration situation of change before and after table 2 preparation for treating of the present invention
3. preparation for treating acquired immune deficiency syndrome (AIDS) CD4 situation of change of the present invention (table 3):
CD4 situation of change (individual/μ l) before and after table 3 preparation for treating of the present invention
Two, model case:
Case 1:
AIDSinfected patient Lee, company clerk, when within 2009, there is erythra, primary dcreening operation HIV is positive, makes a definite diagnosis HIV infect by confirmatory test.Within 2004, start to accept HAART, survey at that time cd4 cell and be counted as 529, body weight is 55kg, start to occur inappetence in August, 2010, dyspepsia, spirit is poor, become thin, weak, spontaneous perspiration, easy catching a cold, 10 times every year on average, diarrhoea, average every day 5 times, watery stool, time have a fear of cold, acid regurgitation, vomiting watery fluid, deep pulse is unable, pale tongue with white fur, from taking diarrhea, have no improvement, then hospital admission, survey cd4 cell and be counted as 302, body weight is 45kg, the traditional Chinese medical science is examined as having loose bowels, syndrome of yang deficiency of spleen and kidney, take the capsule of the embodiment of the present invention 4, every day three times, each three, every about 1.8g, in January, 2013, survey cd4 cell and be counted as 625, body weight is 56kg, appetite is normal, digest, stool is normal, on average once a day, energetic.
Case 2
AIDSinfected patient Zhang, driver, takes drugs in start injection in 2008, when frequent, within 1 day, will inject 3 times, has repeatedly with other people shared syringe to be, and when Yin Gaore will be in hospital in the end of the year 2011, primary dcreening operation HIV is positive, is diagnosed as HIV infects by Guangxi District CDC confirmatory test.Survey at that time cd4 cell and be counted as 568, start to occur becoming thin in February, 2012, weak, spontaneous perspiration, easy catching a cold, on average monthly 1 time, inappetence, dyspepsia, spirit is poor, time have a fear of cold, time have an acid regurgitation, vomiting watery fluid, deep-slow pulse is unable, pale tongue with white fur, often suffer from diarrhoea, every day 4～5 times, from taking Western medicine, have no improvement, Sui Laiwoyuan center is medical, survey cd4 cell and be counted as 216, the traditional Chinese medical science is examined as sexual impotence, syndrome of yang deficiency of spleen and kidney, give the oral liquid of this prescription embodiment of the present invention 2, every day three times, each 20ml, in February, 2013, survey cd4 cell and be counted as 438, appetite is normal, digest, stool is normal, on average spirit is good once a day.
Case 3
AIDSinfected patient deep certain, 27 years old, professional, people from Tiandeng County, Guangxi, finds that in 2009 HIV is positive, in Qi Yue, 2011 Yin Gaore is in hospital and by Guangxi District CDC confirmatory test, is diagnosed as HIV and infects.Surveyed at that time cd4 cell and be counted as and start to occur becoming thin in April, 513,2012, weak, spontaneous perspiration, inappetence, dyspepsia, often diarrhoea, every day 4～5 times, takes Western medicine certainly, have no improvement, certainly take Western medicine, have no improvement, through medical, give the tablet of this prescription embodiment of the present invention 6, every day three times, each three, every about 1.5g, in February, 2013, to survey cd4 cell and be counted as 422, appetite is normal, can eat 3 amount rice for every, digest, stool is normal, and every day 1 time, spirit takes a turn for the better.
clinical conclusion
Medicine of the present invention and antiviral combination application, clinical effectiveness shows, medicine of the present invention and antiviral Western medicine use in conjunction are after 6 months, except myalgia and menoxenia, other symptom and signs all improve significantly, wherein, inappetence, dyspepsia, weak, indigestion and loss of appetite, suffer from diarrhoea, breathe hard and the curative effect of lumbago is better than using merely antiviral agents, to the curative effect of other symptom and signs with simple by antiviral agents there are no significant difference.Illustrate that medicine of the present invention can treat the diarrhoea that acquired immune deficiency syndrome (AIDS) causes, regulate patient's gastrointestinal function normal, appetite is normal, digest raising immunity.
Claims (4)
1. the medicine for the treatment of acquired immune deficiency syndrome (AIDS) diarrhoea, is characterized in that, is to be made by the raw material of Chinese medicine of following parts by weight: Radix Codonopsis 10～30; Rhizoma Atractylodis 10～25; The Rhizoma Atractylodis Macrocephalae 15～40; Poria 5～15; Seem Lablab Album 10～20; Rhizoma Zingiberis Preparatum 10～20; Herba Pogostemonis 20～30; Fructus Psoraleae 10～20; Semen Myristicae 10～20; Radix Puerariae 15～30; The Radix Pulsatillae 15～40; Radix Aconiti Lateralis Preparata 10～20.
2. the medicine of the diarrhoea of the treatment acquired immune deficiency syndrome (AIDS) as described in claim l, is characterized in that, described medicine is oral liquid, granule, capsule, tablet or other pharmaceutically useful dosage form.
3. the production method of the medicine that the treatment acquired immune deficiency syndrome (AIDS) as described in claim l is suffered from diarrhoea, it is characterized in that, get by weight ratio Radix Codonopsis, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Poria, Seem Lablab Album, Rhizoma Zingiberis Preparatum, Herba Pogostemonis, Fructus Psoraleae, Semen Myristicae, Radix Puerariae, the Radix Pulsatillae and Radix Aconiti Lateralis Preparata, by gross weight, add water 5-8 and doubly decoct secondary, each 2 hours, collecting decoction, filtered, add adjuvant, make oral liquid.
4. the production method of the medicine that the treatment acquired immune deficiency syndrome (AIDS) as described in claim l is suffered from diarrhoea, it is characterized in that, get by weight ratio Radix Codonopsis, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Poria, Seem Lablab Album, Rhizoma Zingiberis Preparatum, Herba Pogostemonis, Fructus Psoraleae, Semen Myristicae, Radix Puerariae, the Radix Pulsatillae and Radix Aconiti Lateralis Preparata, by gross weight, add water 5-8 and doubly decoct secondary, each 2 hours, collecting decoction, filter, be concentrated into relative density and be 1.28～1.30 thick paste, at 80 ℃, dry, pulverize into below fine powder again, add adjuvant, mix granulation agent, capsule or tablet.
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