CN105456897A - Traditional Chinese medicine composition containing argy wormwood leaf for treating spleen deficiency gasterasthenia type chronic gastritis - Google Patents
Traditional Chinese medicine composition containing argy wormwood leaf for treating spleen deficiency gasterasthenia type chronic gastritis Download PDFInfo
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- CN105456897A CN105456897A CN201511007002.4A CN201511007002A CN105456897A CN 105456897 A CN105456897 A CN 105456897A CN 201511007002 A CN201511007002 A CN 201511007002A CN 105456897 A CN105456897 A CN 105456897A
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition containing argy wormwood leaf for treating spleen deficiency gasterasthenia type chronic gastritis. The traditional Chinese medicine composition is prepared from the following raw materials: argy wormwood leaf, black soybean product, tuckahoe, rhizome of swordlike atractylodes, Chinese yam, villous amomum fruit, gordon euryale seed, stem of noble dendrobium, stem and leaf of South chrysanthemum, rose, lesser galangal rhizome and licorice root. The formula of the traditional Chinese medicine composition provided by the invention accords with regulations of Pharmacopoeia of People's Republic of China, abides by a compatible principle of monarch, minister, assistant and guide of the traditional Chinese medicine science, is reasonable in ingredient, and makes a clear distinction between an important one and a lesser one to achieve mutual gains. All the medicines are coordinated properly, so that the traditional Chinese medicine composition has the effects of nourishing stomach and spleen, promoting qi circulation to relieve pain, regulating stomach qi, and invigorating qi and blood, and clinical experiments prove that the traditional Chinese medicine composition can effectively relieve symptoms of epigastric pain, abdominal distention, early satiety, belching, acid regurgitation, heartburn, nausea and vomiting of patients, and has good clinical values of strong pertinence, quick effect, short treatment course, high cure rate and small toxic or side effects.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition of the treatment insufficiency of the spleen stomach weak type chronic gastritis containing Folium Artemisiae Argyi.
Background technology
Chronic gastritis refers to the gastric mucosa chronic inflammatory disease or atrophic lesion that are caused by different pathogeny, after its essence is that gastric epithelial suffers repeatedly to damage, due to the regeneration capacity that mucosa is special, so that mucosa is reconstructed, and finally cause the atrophy of irreversible intrinsic gastric gland body, even disappear.It is a kind of common gastrointestinal disease, and how slow onset is, and its sickness rate ranks first in various gastropathy, and male is more than women, increases sickness rate increase gradually with the age.
Most of Patients with Chronic Gastritis is asymptomatic or upper abdomen dull pain, Abdeminal pain, food indigestion, nausea and vomiting, belch and the acid regurgitation etc. that have degree different often.
The etiology and pathogenesis of chronic gastritis is illustrated not yet completely, may with following 5 factors about the sequel of (1) acute gastritis: after acute gastritis, and gastric mucosal lesions more not or recurrent exerbation, all can form chronic gastritis lastingly; (2) zest food and medicine; (3) reflux of duodenal juice enters stomach; (4) generation of some autoimmune disease, as chronic thyroiditis, hypothyroidism or hyperfunction, insulin-dependent diabetes, chronic adrenocortical insufficiency etc.; (5) viral infection factor.
Gastritis is divided into 4 classes by the traditional Chinese medical science usually, belongs to the disease category such as Chinese medicine " gastric abscess ", " feeling of fullness ", " acid regurgitation ", " noisy ", " indigestion and loss of appetite ", be respectively: hepatogastric vital energy stagnation type, deficiency of the spleen and heat of the stomach type, due to weakness of spleen and stomach, type of deficiency of stomach yin.The cause of disease of gastritis is more complicated, and how because long-term feelings will is unsuccessful, eating and drinking without temperance, work and rest is not normal, causes depression of liver-QI, dysfunction of the spleen in transportation, and gastral cavilty is become estranged, gas virtual loss with the passing of time, thus causes all symptoms.Determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs should be given clinically according to the practical situation of patient.
Insufficiency of the spleen stomach weak type chronic gastritis is the common type of chronic gastritis, and patient's gastral cavilty falling inflation is not relaxed, inappetence, acid regurgitation, has a dull ache, and meets cold increasing the weight of, must warm up then light, when starving, pain very, and feed slightly subtracts, loose stool, spiritlessness and weakness, pale tongue, fat large, limit have tooth to print, and white and thin fur, pulse condition sinks thin and delicate or floating unable greatly.Card belongs to deficiency of QI in middle-JIAO, Deficiency and coldness of spleen and stomach, suitable invigorating the spleen and replenishing QI, spleen invigorating stomach warming.
Because Chinese traditional treatment has abundant medication experience and Chinese medical theory basis, stress determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, to the understanding of insufficiency of the spleen stomach weak type chronic gastritis etiology and pathogenesis or diagnoses and treatment aspect modern Chinese medicine all makes some progress, for dissimilar gastritis, can suit the remedy to the case, reasonable compatibility, thus play the effect shortening the course of disease, cure completely.
At present the patent of invention of disclosed treatment chronic gastritis has a lot, such as: 201310693697.0,201510051352.4,201410556293.1,201310457618.6 etc.But chronic gastritis disease type is various, the patent of invention of stomach weak type chronic gastritis that immunotherapy targeted autoantibody is insufficiency of the spleen is little, Chinese patent application 201410771775.9 discloses a kind of Chinese medicine for the treatment of insufficiency of the spleen stomach weak type chronic gastritis, makes primarily of the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Dioscoreae, Semen Coicis, Cortex Magnoliae Officinalis, Rhizoma Alpiniae Officinarum, Fructus Jujubae, Radix Angelicae Sinensis, Radix Ginseng and Radix Glycyrrhizae.Although this invention Chinese medicine has the effect of spleen reinforcing nourishing the stomach, mediation gastric qi, the gastritis disease of patient can be alleviated, containing rare medicinal herbss such as Radix Angelicae Sinensis, Radix Ginseng and Radix Codonopsis in this invention medicine, source is few, and cost is high, significantly limit the use of this invention medicine.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition for the treatment of insufficiency of the spleen stomach weak type chronic gastritis, by selecting suitable medical material and regulating compatibility, reaches with strong points, effective fast, short treating period, cure rate are high, toxic and side effects is little object.
For realizing object of the present invention, inventor is according to the research of theory of Chinese medical science and clinical test repeatedly and checking, and provide a kind of Chinese medicine composition for the treatment of insufficiency of the spleen stomach weak type chronic gastritis, its technical scheme is as follows:
Chinese medicine composition of the present invention comprises the raw materials of following parts by weight:
Folium Artemisiae Argyi 15-30 part, Glycine max (L.) Merr. 13-25 part, Poria 14-24 part, Rhizoma Atractylodis 9-17 part, Rhizoma Dioscoreae 11-17 part, Fructus Amomi 9-15 part, Semen Euryales 7-13 part, Herba Dendrobii 8-13 part, Caulis et Folium Chrysanthemi segeti 6-13 part, Flos Rosae Rugosae 5-12 part, Rhizoma Alpiniae Officinarum 4-9 part and Radix Glycyrrhizae 5-11 part.
In this ratio range, the comparatively significant proportionings of preferred 3 curative effects:
Proportioning 1: Folium Artemisiae Argyi 15 parts, Glycine max (L.) Merr. 13 parts, 14 parts, Poria, Rhizoma Atractylodis 9 parts, Rhizoma Dioscoreae 11 parts, Fructus Amomi 9 parts, Semen Euryales 7 parts, Herba Dendrobii 8 parts, Caulis et Folium Chrysanthemi segeti 6 parts, Flos Rosae Rugosae 5 parts, Rhizoma Alpiniae Officinarum 4 parts and 5 parts, Radix Glycyrrhizae.
Proportioning 2: Folium Artemisiae Argyi 30 parts, Glycine max (L.) Merr. 25 parts, 24 parts, Poria, Rhizoma Atractylodis 17 parts, Rhizoma Dioscoreae 17 parts, Fructus Amomi 15 parts, Semen Euryales 13 parts, Herba Dendrobii 13 parts, Caulis et Folium Chrysanthemi segeti 13 parts, Flos Rosae Rugosae 12 parts, Rhizoma Alpiniae Officinarum 9 parts and 11 parts, Radix Glycyrrhizae.
Proportioning 3: Folium Artemisiae Argyi 23 parts, Glycine max (L.) Merr. 19 parts, 19 parts, Poria, Rhizoma Atractylodis 13 parts, Rhizoma Dioscoreae 14 parts, Fructus Amomi 13 parts, Semen Euryales 10 parts, Herba Dendrobii 10 parts, Caulis et Folium Chrysanthemi segeti 9 parts, Flos Rosae Rugosae 7 parts, Rhizoma Alpiniae Officinarum 6 parts and 8 parts, Radix Glycyrrhizae.
Correspondingly, the present invention also provides the preparation method of described Chinese medicine composition, comprises the following steps:
S1, take each taste raw medicinal material, respectively decontamination, clean, dry, after section, be ground into coarse powder;
S2, by Folium Artemisiae Argyi, Glycine max (L.) Merr., Rhizoma Dioscoreae, Fructus Amomi, Caulis et Folium Chrysanthemi segeti and Flos Rosae Rugosae coarse powder mixing, add water according to the 7-14 times amount of coarse powder gross weight, backflow decocts 2-5 hour, filters, merging filtrate, is evaporated to the Chinese medical concrete I that relative density is 1.25-1.35 under 45-65 DEG C of condition;
S3, Poria, Rhizoma Atractylodis, Semen Euryales, Herba Dendrobii, Rhizoma Alpiniae Officinarum and Radix Glycyrrhizae coarse powder to be mixed, the alcoholic solution that volumetric concentration is 47-63% is added according to the 4-9 times amount of coarse powder gross weight, soak 18-30h, reflux, extract, 3-6 time again, each 2-6h, filters, get filtrate, filtrate cold preservation after alkalization leaves standstill, and refilter, gained filtrate obtains extractum thing II through concentrating under reduced pressure and microwave drying;
S4, fully mixed by extractum thing I and II, take inlet temperature as 120-140 DEG C, leaving air temp is that the centrifugal spray drying of 75-95 DEG C is prepared into Chinese medicinal ointment powder;
S5, Chinese medicinal ointment powder is fully water-soluble, drying under reduced pressure, pulverizes grinding, crosses 80-200 mesh sieve, obtains traditional Chinese medicine composite fine powder.
Further, utilize modern general Chinese medicine composition technology, Chinese medicine composition of the present invention makes tablet, capsule, granule or powder.
Source, the nature and flavor of Chinese prescription of the present invention Chinese crude drug used, return through and effect:
Folium Artemisiae Argyi: this product is the dried leaves of feverfew Chinese mugwort.Acrid in the mouth, hardship, warm in nature; Return liver,spleen,kidney warp; There is dispersing cold for relieving pain, regulate the flow of vital energy along blood, effect by cold damp eliminating.Hide hemorrhoid for only dysentery with red and white feces and five and rush down blood, long clothes only cold-dysentery, juice kills ascarid again, separates distention and fullness in the abdomen.
Glycine max (L.) Merr.: the seed (Semen sojae atricolor) for the seed coat black of legume soybean steams net for catching birds or fish and processes.Sweet in the mouth, warm in nature; Return spleen, stomach warp; There is expelling wind and removing dampness, effect of invigorating the spleen and benefiting QI.For insufficiency of the spleen lack of appetite, gastral cavilty harm is vexed, five hide not enough gas, gastric qi knot is long-pending.
Poria: this product is the dry sclerotia of On Polyporaceae Poria.Sweet in the mouth, light, property is put down; GUIXIN, lung, spleen, kidney channel; There is promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, effect of spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Rhizoma Atractylodis: this product is the dry rhizome of feverfew Atractylodes lancea (Thunb.) DC..Acrid in the mouth, hardship, warm in nature; Return spleen, stomach, Liver Channel; Have drying damp and strengthening spleen, expelling wind and cold, effect of improving eyesight.For distension and fullness in the abdomen, have loose bowels, rheumatic arthralgia, wind and cold.
Rhizoma Dioscoreae: this product is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae.Sweet in the mouth, property is put down; Return spleen, lung, kidney channel; Have spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, effect of the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, frequent micturition, and deficiency-heat is quenched one's thirst.
Fructus Amomi: this product is the dry mature fruit of zingiberaceous plant Fructus Amomi.Acrid in the mouth, warm in nature; Return spleen, stomach, kidney channel;
There is removing dampness appetizing, warming spleen and stopping diarrha, antiabortive effect of regulating the flow of vital energy.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.
Semen Euryales: this product is the dry mature kernal of nymphaeaceae plant Gorgon euryale.Sweet in the mouth, puckery, property is put down; Return spleen, kidney channel; There is supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, effect of damp eliminating leukorrhagia stopping.For enuresis frequent micturition, insufficiency of the spleen chronic diarrhea.
Herba Dendrobii: this product is the fresh or dry stem of orchid dendrobium loddigesii Rolfe.Sweet in the mouth, cold nature; Return stomach, kidney channel; There is reinforcing stomach reg fluid, effect of nourishing YIN and clearing away heat.Lose for cloudy impairment of body fluid, xerostomia excessive thirst, lack of appetite is retched.
Caulis et Folium Chrysanthemi segeti: this product is the stem and leaf of feverfew Caulis et Folium Chrysanthemi segeti.Acrid in the mouth, sweet, cool in nature; GUIXIN, spleen, stomach warp; Have and taste, disappear and talk drink, effect of tranquilizing mind.Main incoordination between the spleen and stomach, constipation and anuresis, cough with copious phlegm, dysphoria with smothery sensation is uneasy.
Flos Rosae Rugosae: this product is the dry flower of rosaceous plant Flos Rosae Rugosae.Sweet in the mouth, micro-hardship, warm in nature; Return liver, spleen channel; There are promoting QI circulation for relieving depression, and blood, effect of pain relieving.For stomachache due to hyperactive liver-QI attacking the stomach, lack of appetite vomiting and nausea.
Rhizoma Alpiniae Officinarum: this product is the dry rhizome of zingiberaceous plant Rhizoma Alpiniae Officinarum.Acrid in the mouth, hot in nature; Return spleen, stomach warp.There is warming stomach for dispelling cold, the effect of the pain relieving that helps digestion.For coldness and pain in the epigastrium, gastrofrigid vomiting, belch acid regurgitation.
Radix Glycyrrhizae: this product is glycyrrhizic legume dry root, and spring, Qiu Erji excavate, removing fibrous root, dries sweet in the mouth, and property is put down; GUIXIN, lung, spleen, stomach warp; There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, effect of coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong, effect of coordinating the actions of various ingredients in a prescription.
The compatibility analysis of Chinese medicine composition of the present invention:
Chinese medicine composition prescription of the present invention to the dialectical cognition of insufficiency of the spleen stomach weak type chronic gastritis according to Chinese medicine rationale, is followed the compatibility theory of Chinese medicine, is enhanced the use amount of medical material.This prescription is with Folium Artemisiae Argyi, Glycine max (L.) Merr. and Poria for monarch drug, dispersing cold for relieving pain, regulates the flow of vital energy along blood, strengthening the spleen stomach function regulating; With Rhizoma Atractylodis, Rhizoma Dioscoreae, Fructus Amomi and Semen Euryales for ministerial drug, drying damp and strengthening spleen, the lung benefiting that promotes the production of body fluid, warming spleen and stopping diarrha; With Herba Dendrobii, Caulis et Folium Chrysanthemi segeti, Flos Rosae Rugosae and Rhizoma Alpiniae Officinarum for adjuvant drug, expelling wind and cold, help digestion pain relieving, and pneumostatic is with fixed attention; With Radix Glycyrrhizae for making medicine, invigorating the spleen and replenishing QI, relieving spasm to stop pain, the coordinating the actions of various ingredients in a prescription property of medicine.All medicines coordinate, and complement each other, synergism, plays strengthening the spleen and nourishing the stomach altogether, regulating blood flow to alleviate pains, help digestion and medium effect, have very significant curative effect to the insufficiency of the spleen stomach weak type chronic gastritis for the treatment of.
Compared with prior art, Chinese medicine of the present invention has following advantage:
Compared with the chemotherapeutic agent of Current therapeutic insufficiency of the spleen stomach weak type chronic gastritis, Chinese medicine composition of the present invention meets " Chinese medicine meets Pharmacopoeia of People's Republic of China " relevant regulations completely, is made up of pure natural Chinese herbal medicine, and reasonable, all medicine of compatibility is worked in coordination with, stress conditioning;
Clinical trial certificate, compared with positive control drug hydrotalcite tablet, Chinese medicine composition of the present invention has rapid-action, that short treating period, cure rate are high and toxic and side effects is little advantage.
Chinese medicine composition preparation technology of the present invention is simple and easy to do, efficacy stability, be applicable to be made into various dosage form, is beneficial to and promotes the use of.
Detailed description of the invention
Below will the present invention is described further by specific embodiment, but the present invention is not limited only to following examples.It will be understood by those skilled in the art that for, the present invention is except following examples, the change carried out the present invention under the condition not departing from content of the present invention, spirit and scope, combination or replacement, be apparent for a person skilled in the art, be all included within the scope of the present invention.
embodiment one
The embodiment of the present invention 1 Chinese medicine composition is made up of the raw materials of following parts by weight:
Folium Artemisiae Argyi 15 parts, Glycine max (L.) Merr. 13 parts, 14 parts, Poria, Rhizoma Atractylodis 9 parts, Rhizoma Dioscoreae 11 parts, Fructus Amomi 9 parts, Semen Euryales 7 parts, Herba Dendrobii 8 parts, Caulis et Folium Chrysanthemi segeti 6 parts, Flos Rosae Rugosae 5 parts, Rhizoma Alpiniae Officinarum 4 parts and 5 parts, Radix Glycyrrhizae.
Preparation method is as follows:
S1, take each taste raw medicinal material, respectively decontamination, clean, dry, after section, be ground into coarse powder;
S2, by Folium Artemisiae Argyi, Glycine max (L.) Merr., Rhizoma Dioscoreae, Fructus Amomi, Caulis et Folium Chrysanthemi segeti and the mixing of Flos Rosae Rugosae coarse powder, to add water according to 7 times amount of coarse powder gross weight, backflow decoction 2 hours, filter, merging filtrate, is evaporated to the Chinese medical concrete I that relative density is 1.25 under 45 DEG C of conditions;
S3, Poria, Rhizoma Atractylodis, Semen Euryales, Herba Dendrobii, Rhizoma Alpiniae Officinarum and Radix Glycyrrhizae coarse powder to be mixed, the alcoholic solution that volumetric concentration is 47% is added according to 4 times amount of coarse powder gross weight, soak 18h, reflux, extract, 3 times again, each 2h, filters, get filtrate, filtrate cold preservation after alkalization leaves standstill, and refilter, gained filtrate obtains extractum thing II through concentrating under reduced pressure and microwave drying;
S4, fully mixed by extractum thing I and II, be 120 DEG C with inlet temperature, leaving air temp is that the centrifugal spray drying of 75 DEG C is prepared into Chinese medicinal ointment powder;
S5, Chinese medicinal ointment powder is fully water-soluble, drying under reduced pressure, pulverizes grinding, crosses 100 mesh sieves, obtains traditional Chinese medicine composite fine powder.
S6, raw material of Chinese medicine fine powder is fully water-soluble, add corresponding adjuvant, after tabletting, be prepared into tablet.
embodiment two
The embodiment of the present invention 2 Chinese medicine composition is made up of the raw materials of following parts by weight:
Folium Artemisiae Argyi 30 parts, Glycine max (L.) Merr. 25 parts, 24 parts, Poria, Rhizoma Atractylodis 17 parts, Rhizoma Dioscoreae 17 parts, Fructus Amomi 15 parts, Semen Euryales 13 parts, Herba Dendrobii 13 parts, Caulis et Folium Chrysanthemi segeti 13 parts, Flos Rosae Rugosae 12 parts, Rhizoma Alpiniae Officinarum 9 parts and 11 parts, Radix Glycyrrhizae.
Preparation method is as follows:
S1, take each taste raw medicinal material, respectively decontamination, clean, dry, after section, be ground into coarse powder;
S2, by Folium Artemisiae Argyi, Glycine max (L.) Merr., Rhizoma Dioscoreae, Fructus Amomi, Caulis et Folium Chrysanthemi segeti and the mixing of Flos Rosae Rugosae coarse powder, to add water according to 14 times amount of coarse powder gross weight, backflow decoction 5 hours, filter, merging filtrate, is evaporated to the Chinese medical concrete I that relative density is 1.35 under 65 DEG C of conditions;
S3, Poria, Rhizoma Atractylodis, Semen Euryales, Herba Dendrobii, Rhizoma Alpiniae Officinarum and Radix Glycyrrhizae coarse powder to be mixed, the alcoholic solution that volumetric concentration is 63% is added according to the 4-9 times amount of coarse powder gross weight, soak 30h, reflux, extract, 6 times again, each 6h, filters, get filtrate, filtrate cold preservation after alkalization leaves standstill, and refilter, gained filtrate obtains extractum thing II through concentrating under reduced pressure and microwave drying;
S4, fully mixed by extractum thing I and II, be 140 DEG C with inlet temperature, leaving air temp is that the centrifugal spray drying of 95 DEG C is prepared into Chinese medicinal ointment powder;
S5, Chinese medicinal ointment powder is fully water-soluble, drying under reduced pressure, pulverizes grinding, crosses 200 mesh sieves, obtains traditional Chinese medicine composite fine powder.
S6, raw material of Chinese medicine fine powder is fully water-soluble, add corresponding adjuvant, be prepared into granule.
embodiment three
The embodiment of the present invention 3 Chinese medicine composition is made up of the raw materials of following parts by weight:
Folium Artemisiae Argyi 23 parts, Glycine max (L.) Merr. 19 parts, 19 parts, Poria, Rhizoma Atractylodis 13 parts, Rhizoma Dioscoreae 14 parts, Fructus Amomi 13 parts, Semen Euryales 10 parts, Herba Dendrobii 10 parts, Caulis et Folium Chrysanthemi segeti 9 parts, Flos Rosae Rugosae 7 parts, Rhizoma Alpiniae Officinarum 6 parts and 8 parts, Radix Glycyrrhizae.
Preparation method is as follows:
S1, take each taste raw medicinal material, respectively decontamination, clean, dry, after section, be ground into coarse powder;
S2, by Folium Artemisiae Argyi, Glycine max (L.) Merr., Rhizoma Dioscoreae, Fructus Amomi, Caulis et Folium Chrysanthemi segeti and the mixing of Flos Rosae Rugosae coarse powder, to add water according to 10 times amount of coarse powder gross weight, backflow decoction 3.5 hours, filter, merging filtrate, is evaporated to the Chinese medical concrete I that relative density is 1.30 under 55 DEG C of conditions;
S3, Poria, Rhizoma Atractylodis, Semen Euryales, Herba Dendrobii, Rhizoma Alpiniae Officinarum and Radix Glycyrrhizae coarse powder to be mixed, the alcoholic solution that volumetric concentration is 55% is added according to 7.5 times amount of coarse powder gross weight, soak 24h, reflux, extract, 4 times again, each 4h, filters, get filtrate, filtrate cold preservation after alkalization leaves standstill, and refilter, gained filtrate obtains extractum thing II through concentrating under reduced pressure and microwave drying;
S4, fully mixed by extractum thing I and II, be 130 DEG C with inlet temperature, leaving air temp is that the centrifugal spray drying of 85 DEG C is prepared into Chinese medicinal ointment powder;
S5, Chinese medicinal ointment powder is fully water-soluble, drying under reduced pressure, pulverizes grinding, crosses 100 mesh sieves, obtains traditional Chinese medicine composite fine powder.
S6, raw material of Chinese medicine fine powder is fully water-soluble, add corresponding adjuvant, be prepared into capsule.
chinese medicine composition pharmacodynamic study of the present invention:
chinese medicine composition of the present invention is on the impact of the insufficiency of the spleen stomach weak type chronic gastritis animal model of multifactor simulation
1, experiment purpose
According to the requirement of " new Chinese medicine pharmaceutical research guide ", study the Pharmacodynamics of traditional Chinese medicine composition for treating of the present invention insufficiency of the spleen stomach weak type chronic gastritis.
2, modeling is tested
Principle: from theory of Chinese medical science and clinical, builds insufficiency of the spleen stomach weak type chronic gastritis disease animal model with induce by multifactor Wisatr system rat such as the addiction for one of five flavors of long period and hungry full overstrains, and carries out cyclic nucleotide (CAmp) assay to this model.
Method: cleaning grade male Wistar healthy rat 60 is selected in this experiment, is provided by Zhongshan University's medical college Experimental Animal Center.10 rats are as Normal group, and all the other 50 rats are for building the animal model of insufficiency of the spleen stomach weak type chronic gastritis.During modeling, first with 2% sodium salicylate gavage, 2ml/ pcs/day, successive administration surrounding.5th week starts, while gavage sodium salicylate, then applies the modeling condition of the weak disease of insufficiency of the spleen stomach, the rat odd-numbered day is run on electric roller type treadmill, and fasting, even-numbered days are at warm water went swimming, and ad lib is quantity-unlimiting, continues surrounding, make the excessive overstrain of animal and irregular diet.
3, grouping administration:
After determining modeling success, 50 rat models are divided into 5 groups at random, 10/group, are respectively: model group, positive drug control group, high, in and low dose group.Wherein, positive drug control group rat oral gavage administration hydrotalcite tablet (the accurate word H20103163 of traditional Chinese medicines, Sichuan Jewelland Pharmaceutical Co., Ltd.), a 30g/Kg, 3 times on the one, takes for after feeding 15-30 minute.High, in and low dose group use the tablet prepared according to the specific embodiment of the invention 1 respectively to rat oral gavage, high dose group rat administration 30g/Kg, middle dosage group rat administration 20g/Kg, low dose group rat administration 10g/Kg.Normal group and model group gavage PBS, conventional bar material is fed.Successive administration 21 days, observes the sign performance of 6 groups of rats during medication, and to so animal is got blood respectively and gets gastric mucosa after putting to death use radioimmunology, measures the blood plasma of each group and the CAmp content of gastric mucosa, the results are shown in Table 1.
Experimental result:
Table 1 Chinese medicine composition of the present invention is to the therapeutical effect of gastritis rat model disease
Note: compare with normal group,
### p< 0.001; Compare with model group,
* p< 0.05,
* p< 0.01,
* * p< 0.001; Compare with positive controls,
△ p< 0.05,
△ △ p< 0.01.
As can be seen from Table 1, compared with model group, after rat oral gavage administration Chinese medicine composition of the present invention and positive control drug, insufficiency of the spleen stomach weak type chronic gastritis symptom takes a turn for the better all to some extent.The plasma C AmP of positive controls and high dose group
Have extremely significant diversity (p<0.01) compared with model group, the plasma C AmP of middle dosage group has significant diversity (p<0.05) compared with model group; Positive controls gastric mucosa CAmP has significant diversity (p<0.05) compared with model group, and the gastric mucosa CAmP of high dose has extremely significant diversity (p<0.01) compared with model group, and the present invention is high, in and low dose group disease be improved significantly, hair color gloss, smooth gradually, spirit is recovered gradually, ear color is ruddy, and appetite increases.Illustrate that the present invention has the advantage of its uniqueness in the disease treatment for insufficiency of the spleen stomach weak type chronic gastritis.
chinese medicine composition of the present invention is to the clinical observation on the therapeutic effect of insufficiency of the spleen stomach weak type chronic gastritis clinical volunteers patient
Physical data
1.1 patient's physical data
Choose insufficiency of the spleen stomach weak type Patients with Chronic Gastritis clinical volunteers 120 example of the 5-10 month in 2015 at Guangdong Province overseas Chinese hospital admission, basic age 19-71 year between, the mean age is 35.2 ± 2.1 years old; The course of disease 8 months ~ 18 years, average course of disease is (4.5 ± 3.6) year.Be divided into matched group and treatment group two groups at random, often organize each 60 people, two groups at age, sex, coincident with severity degree of condition without too big-difference (P > 0.05), there is comparability.
1.2 diagnostic criteria
1.2.1 Western medicine diagnose standard
Symptom: often have eating and drinking without temperance or the medical history such as feelings will is not smooth.Symptom is without specificity, and about half has epigastric discomfort, and dull pain, burning pain, pantothenic acid, glutted, nauseating, the indigestion symptom such as belch, loss of appetite, have rotten to the corn person can have a small amount of or a large amount of upper gastrointestinal hemorrhage.
Auxiliary examination: (1) gastroscopy: mucosa injury, visible erythema (point, lamellar, strip), coarse injustice, petechia/speckle, color and luster is gloomy.As there is the rotten to the corn or bile reflux of smooth erosion, protuberance simultaneously, be then diagnosed as superficial gastritis or atrophic gastritis accompanied is rotten to the corn or bile reflux.(2) gastric analysis, PH is most of on the low side.(3) diagnosis of H.P Gastritis: histology, urease, antibacterial culturing, 13C or the 14C urea breath experiment any one positive.(4) coherence check of autoimmune gastritis: should survey PCA and IFA suspected of autoimmune gastritis person, as mostly being positive for this sick PCA, during companion's pernicious anemia, IFA is positive more.
1.2.2 tcm diagnosis standard
With reference to " combination of Chinese and Western medicine diagnosis and treatment project (draft) of insufficiency of the spleen stomach weak type chronic gastritis ", insufficiency of the spleen stomach weak type chronic gastritis has following disease feature:
Main symptom: 1. vague epigastralgia.2. pain relieved by pressing happiness is warm.3. after food, gastral cavity is vexed.4. appetite stimulator.5. loose stool diarrhoea.6. limbs fatigue.7. body of the tongue is light red, has tooth to print, white and thin fur or white.
Secondary card: the 1. visible erythema of gastric mucosa or coarse injustice.2. mucus is thin and many.3. gastric acid is on the low side.4. deep-thready pulse.
Dialectical requirement: possess main symptom 3 and add time card 1, or main symptom 2 adds time card 2.
1.3 inclusive criteria
(1) insufficiency of the spleen stomach weak type chronic gastritis Western medicine diagnose standard or TCM syndrome diagnostic criteria is met; (2) age >=18 years old; (3) the Hospital Ethical Committee examination & verification person of passing through; (4) patient's informed consent, and signature Informed Consent Form person.
1.4 exclusion standard
(1) patient of general or other system disease is had; (2) gestation and women breast-feeding their children; (3) the medicine patient affecting taste and sensory function was taken in nearly 3 months; (4) ethanol, drug dependence patient, and to trial drug allergy sufferers.
2, Therapeutic Method:
Experimental group: adopt Chinese medicine composition tablet prepared by embodiment 1, every day 3 times, one time 1 (containing crude drug amount 350mg/ sheet), 1-2 hour after the meal oral, 7 days courses for the treatment of, totally 4 courses for the treatment of.
Matched group: oral hydrotalcite tablet (the accurate word H20103163 of traditional Chinese medicines, Sichuan Jewelland Pharmaceutical Co., Ltd.), every day 3 times, a 1-2 sheet.1-2 hour after the meal, sleep before or stomach discomfort time take, 7 days courses for the treatment of, totally 4 courses for the treatment of.
3, efficacy assessment standard:
" new Chinese medicine guideline of clinical investigations " with reference to Zheng Xiaoying chief editor in 2002 works out TCM syndrome standards of grading:
Recovery from illness: the stomach pain symptoms such as stomach dull pain, distending pain disappear, abdominal distention after meal, vomiting disappear, and gastric motility recovers, and metabolism recovers normal;
Effective: stomach pain symptom alleviates, attack times reduces, and gastric motility recovers to some extent;
Invalid: symptom is without improvement or aggravation;
Cure rate=recovery from illness/total number of cases * 100%
Total effective rate=(recovery from illness+effective)/total number of cases * 100%
4, statistical method:
(1) employing SPSS17.O statistical analysis software calculates by statistical analysis.
(2) all statistical test all adopt two-sided test, and P<0.05 has statistical significance by being considered to checked difference.
(3) employing x scholar SD is carried out statistics description by different treatment group measurement data.Adopt difference before and after in paired t-test comparable group, independent samples t-test compares group difference.Before and after two groups of treatments, change adopts variance analysis (ANOVA) and Wileoxon rank test to compare.
(4) enumeration data that different treatment group is gone to a doctor for each time adopts frequency (constituent ratio) to carry out statistics and describes.
5, therapeutic outcome:
According to clinical observation, two groups of patients oral Chinese medicine composition of the present invention and hydrotalcite tablet respectively, the Clinical efficacy comparison after 2 courses for the treatment of and 4 course of therapy sees the following form:
Clinical efficacy comparison after table 2 liang group patient 2 course of therapy
As can be seen from Table 2,60 routine insufficiency of the spleen stomach weak type chronic gastritis clinical patients of oral Chinese medicine composition of the present invention, after two course of therapy, the patient exceeding half reaches the effect of healing, total effective rate up to 95.0% only have the gastritis symptom of 3 patients do not have be improved significantly.And in 60 routine patients of oral positive control drug hydrotalcite tablet treatment, have the symptom of 14 patients to have no improvement, even aggravation, total effective rate only has 76.7%.Chinese medicine composition good effect of the present invention is described, instant effect, the treatment time that obviously can shorten insufficiency of the spleen stomach weak type chronic gastritis is long, alleviate in time patient misery.
Clinical efficacy comparison after table 3 liang group patient 4 course of therapy
After two course of therapy, medication treatment is continued to the clinical volunteers reaching curative effect not yet, as can be seen from Table 3, extends administration time, the cure rate of two groups all increases, but traditional Chinese medicine composition for treating group cure rate (90.0%) of the present invention is still higher than positive drug control group (85.0%).And hydrotalcite tablet treatment has 9 conditions of patients to can not get alleviating, and brings great misery to patient.
In addition, by the diagnostic observation during 120 routine clinical volunteers's medications and tracking access, find that the untoward reaction such as constipation in various degree, loose stool, xerostomia and anorexia have appearred in the patient of 20-40% during oral positive control drug; And 60 of oral Chinese medicine composition of the present invention routine patient's physical and mental statuses are good, all do not occur untoward reaction, drug safety of the present invention is described, toxic and side effects is little, has good clinical generalization value.
Claims (6)
1. a Chinese medicine composition for the treatment insufficiency of the spleen stomach weak type chronic gastritis containing Folium Artemisiae Argyi, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight:
Folium Artemisiae Argyi 15-30 part, Glycine max (L.) Merr. 13-25 part, Poria 14-24 part, Rhizoma Atractylodis 9-17 part, Rhizoma Dioscoreae 11-17 part, Fructus Amomi 9-15 part, Semen Euryales 7-13 part, Herba Dendrobii 8-13 part, Caulis et Folium Chrysanthemi segeti 6-13 part, Flos Rosae Rugosae 5-12 part, Rhizoma Alpiniae Officinarum 4-9 part and Radix Glycyrrhizae 5-11 part.
2. the Chinese medicine composition of the treatment insufficiency of the spleen stomach weak type chronic gastritis containing Folium Artemisiae Argyi according to claim 1, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight:
Folium Artemisiae Argyi 15 parts, Glycine max (L.) Merr. 13 parts, 14 parts, Poria, Rhizoma Atractylodis 9 parts, Rhizoma Dioscoreae 11 parts, Fructus Amomi 9 parts, Semen Euryales 7 parts, Herba Dendrobii 8 parts, Caulis et Folium Chrysanthemi segeti 6 parts, Flos Rosae Rugosae 5 parts, Rhizoma Alpiniae Officinarum 4 parts and 5 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition of the treatment insufficiency of the spleen stomach weak type chronic gastritis containing Folium Artemisiae Argyi according to claim 1, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight:
Folium Artemisiae Argyi 30 parts, Glycine max (L.) Merr. 25 parts, 24 parts, Poria, Rhizoma Atractylodis 17 parts, Rhizoma Dioscoreae 17 parts, Fructus Amomi 15 parts, Semen Euryales 13 parts, Herba Dendrobii 13 parts, Caulis et Folium Chrysanthemi segeti 13 parts, Flos Rosae Rugosae 12 parts, Rhizoma Alpiniae Officinarum 9 parts and 11 parts, Radix Glycyrrhizae.
4. the Chinese medicine composition of the treatment insufficiency of the spleen stomach weak type chronic gastritis containing Folium Artemisiae Argyi according to claim 1, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight:
Folium Artemisiae Argyi 23 parts, Glycine max (L.) Merr. 19 parts, 19 parts, Poria, Rhizoma Atractylodis 13 parts, Rhizoma Dioscoreae 14 parts, Fructus Amomi 13 parts, Semen Euryales 10 parts, Herba Dendrobii 10 parts, Caulis et Folium Chrysanthemi segeti 9 parts, Flos Rosae Rugosae 7 parts, Rhizoma Alpiniae Officinarum 6 parts and 8 parts, Radix Glycyrrhizae.
5., according to the Chinese medicine composition of the arbitrary described treatment insufficiency of the spleen stomach weak type chronic gastritis containing Folium Artemisiae Argyi of claim 1-4, it is characterized in that, described Chinese medicine composition makes tablet, capsule, granule or powder.
6., according to the preparation method of the Chinese medicine composition of the arbitrary described treatment insufficiency of the spleen stomach weak type chronic gastritis containing Folium Artemisiae Argyi of claim 1-5, it is characterized in that, the preparation method of described Chinese medicine composition comprises the following steps:
S1, take each taste raw medicinal material, respectively decontamination, clean, dry, after section, be ground into coarse powder;
S2, by Folium Artemisiae Argyi, Glycine max (L.) Merr., Rhizoma Dioscoreae, Fructus Amomi, Caulis et Folium Chrysanthemi segeti and Flos Rosae Rugosae coarse powder mixing, add water according to the 7-14 times amount of coarse powder gross weight, backflow decocts 2-5 hour, filters, merging filtrate, is evaporated to the Chinese medical concrete I that relative density is 1.25-1.35 under 45-65 DEG C of condition;
S3, Poria, Rhizoma Atractylodis, Semen Euryales, Herba Dendrobii, Rhizoma Alpiniae Officinarum and Radix Glycyrrhizae coarse powder to be mixed, the alcoholic solution that volumetric concentration is 47-63% is added according to the 4-9 times amount of coarse powder gross weight, soak 18-30h, reflux, extract, 3-6 time again, each 2-6h, filters, get filtrate, filtrate cold preservation after alkalization leaves standstill, and refilter, gained filtrate obtains extractum thing II through concentrating under reduced pressure and microwave drying;
S4, fully mixed by extractum thing I and II, take inlet temperature as 120-140 DEG C, leaving air temp is that the centrifugal spray drying of 75-95 DEG C is prepared into Chinese medicinal ointment powder;
S5, Chinese medicinal ointment powder is fully water-soluble, drying under reduced pressure, pulverizes grinding, crosses 80-200 mesh sieve, obtains traditional Chinese medicine composite fine powder.
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| CN105770821A (en) * | 2016-04-12 | 2016-07-20 | 广州三得医疗科技有限公司 | Medicine composition containing folium artemisiae argyi and used for treating functional dyspepsia |
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| CN106177715A (en) * | 2016-08-27 | 2016-12-07 | 孙岳 | A kind of Folium Artemisiae Argyi health preserving tea promoting enterogastric peristalsis and preparation method thereof |
| CN106729329A (en) * | 2017-03-08 | 2017-05-31 | 周明 | A kind of Chinese medicine of incense disorderly for regulating body function and preparation method thereof |
| CN109907145A (en) * | 2019-04-24 | 2019-06-21 | 湖南省定生保健品经营有限公司 | The preparation method and application of tea therapy drink |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105853582A (en) * | 2016-04-08 | 2016-08-17 | 广州暨南生物医药研究开发基地有限公司 | Folium artemisiae argyi containing medicine preparation for treating cholelithiasis and preparation method thereof |
| CN105770821A (en) * | 2016-04-12 | 2016-07-20 | 广州三得医疗科技有限公司 | Medicine composition containing folium artemisiae argyi and used for treating functional dyspepsia |
| CN106177715A (en) * | 2016-08-27 | 2016-12-07 | 孙岳 | A kind of Folium Artemisiae Argyi health preserving tea promoting enterogastric peristalsis and preparation method thereof |
| CN106729329A (en) * | 2017-03-08 | 2017-05-31 | 周明 | A kind of Chinese medicine of incense disorderly for regulating body function and preparation method thereof |
| CN109907145A (en) * | 2019-04-24 | 2019-06-21 | 湖南省定生保健品经营有限公司 | The preparation method and application of tea therapy drink |
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