CN101874874B - Chinese medicinal preparation for treating helicobacter pylori concerned chronic gastritis and preparation method thereof - Google Patents

Chinese medicinal preparation for treating helicobacter pylori concerned chronic gastritis and preparation method thereof Download PDF

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CN101874874B
CN101874874B CN2010102160488A CN201010216048A CN101874874B CN 101874874 B CN101874874 B CN 101874874B CN 2010102160488 A CN2010102160488 A CN 2010102160488A CN 201010216048 A CN201010216048 A CN 201010216048A CN 101874874 B CN101874874 B CN 101874874B
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radix
rhizoma
helicobacter pylori
bletillae
concerned
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CN2010102160488A
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CN101874874A (en
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夏黎明
孟玲
李文华
杨秀军
李凤燕
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夏黎明
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Abstract

The invention discloses a Chinese medicinal preparation for treating helicobacter pylori concerned chronic gastritis, which is prepared from jiuxiang bug, rose, notoginseng root powder, astragalus, szechwon tangshen root, large-headed atractylodes rhizome, cassia twig, white paeony root, golden thread, medcinal evodia fruit, calcined ark shell, cuttlebone, fructus citri immaturus exsiccatus, common bletilla pseudobulb, cinnamomvine, mongolian dandelion herb, areca seed and liquorice root serving as raw materials in a certain weight ratio by a certain process according to different properties of each traditional Chinese medicine. The Chinese medicinal preparation has the advantages of scientific formula and reasonable compatibility, has the effects of warming middle-jiao and invigorating the spleen, regulating the flow of qi and harmonizing stomach, removing blood stasis and stopping pain, eliminating helicobacter pylori, promoting tissue regeneration and treating cutaneous pyogenic infection, protecting mucosa and healing stomach, promoting the healing of mucosa and reducing relapse, and particularly has the unique curative effect on symptoms such as epigastric pain, acid regurgitation, hiccough and eructation, anorexia and acratia, sallow complexion and the like which are caused by gastritis.

Description

A kind of Chinese medicine preparation for the treatment of helicobacter pylori concerned chronic gastritis and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of helicobacter pylori concerned chronic gastritis and preparation method thereof, belong to technical field of Chinese medicines.
Background technology
Helicobacter pylori concerned chronic gastritis is a kind of commonly encountered diseases and frequently-occurring disease, and modern medicine study thinks that the gastritis of 50-90% is relevant with helicobacter pylori infection, this disease sickness rate height, and medical history is long, and the Chang Fanfu outbreak is difficult for radical cure.Along with speeding of growth in the living standard and modern life work rhythm, this disease sickness rate has the trend that rises day by day.Should disease use western medicine at present more, though certain curative effect is arranged, but be difficult for radical cure, often still outbreak repeatedly, protracted course of disease, helicobacter pylori concerned chronic gastritis prolonged illness also is transformed into gastric ulcer easily, it is hemorrhage pathological changes mucosa place also can to occur, causes anemia, and immunity of organisms is reduced, and the formation gastric cancer that can cancerate, threat to life.This serial disease belongs to scopes such as traditional Chinese medical science gastric abscess, syndrome of feeling fullness and distension in the upper abdomen, acid regurgitation, and normal because eating and drinking without temperance, feelings will are lost freely, affection of exogenous wind-cold, weakness of the spleen and stomach are fallen ill.So the key of treatment primary disease is warming middle-JIAO and strengthening the spleen, regulating qi-flowing for harmonizing stomach, blood-activating analgetic.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of helicobacter pylori concerned chronic gastritis, this medicament composing prescription science, compatibility is reasonable, can effectively regulate gastrointestinal function, promote gastric motility, aid digestion, promote the healing of gastric mucosal lesions, make gastrointestinal disorder recover normal.
Another object of the present invention is to provide the preparation method of the Chinese medicine preparation for the treatment of helicobacter pylori concerned chronic gastritis.
The pathogenesis that solution of the present invention the is based on doctor trained in Western medicine principle that combines with the dialectical medication of the traditional Chinese medical science, differential diagnosis of diseases is dialectical oozes mutually, and outstanding the heal method of stomach of promoting tissue regeneration and ulcer healing, cuticula that embodies promotes gastric mucosal lesion reparation and healing in the treatment.At present medical circle generally believes that the gastritis cause of disease and helicobacter pylori infections are closely related, in conjunction with modern pharmacological research, our medicine can play remove helicobacter pylori (helicobacter pylori is hereinafter to be referred as HP), promoting tissue regeneration and ulcer healing, cuticula heal stomach, promote the healing of mucosa pathological changes, reduce effects such as recurrence.Theory of Chinese medical science is thought, the mutual coordination that normally depends on the taste physiological function of digestive system function and the normal performance of suffocating of liver and gall function, and on physiology, the healthy and vigorous then QI and blood of taste biochemistry is active, and liver and gall are taken charge of, and then the taste lifting is orderly.Therefore, uncomfortable, the serious disease prolonged illness of stagnation of liver-QI, changes in temperature, weakness of the spleen and stomach cause stagnation of liver-QI and stomach-QI, qi depression to blood stasis when eating and drinking without temperance injures one's stomach, feelings will is smooth, all can cause the generation of gastritis.Chinese medicines such as the utilization insect medicine Aspongopus of the invention and flower class medicine Flos Rosae Rugosae, tubers medicine Radix Notoginseng powder play regulating qi-flowing for harmonizing stomach, dissipating blood stasis hemostasis, and effects such as subduing swelling and relieving pain have greatly improved clinical efficacy.
Chinese medicine preparation of the present invention is made by following component: (consumption is a weight portion)
Aspongopus 3-12, Flos Rosae Rugosae 3-15, Radix Notoginseng powder 3-10, Radix Astragali 10-30, Radix Codonopsis 6-15, Rhizoma Atractylodis Macrocephalae 6-12, Ramulus Cinnamomi 3-10, Radix Paeoniae Alba 6-15, Rhizoma Coptidis 6-10, Fructus Evodiae 2-4, Concha Arcae (calcined) 10-20, Endoconcha Sepiae 6-15, Fructus Aurantii 6-15, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20, Rhizoma Dioscoreae 10-30, Herba Taraxaci 10-30, Semen Arecae 6-15, Radix Glycyrrhizae 3-10.
Formula optimization weight (part) ratio range of preparation Chinese medicine preparation of the present invention is:
Aspongopus 6-10, Flos Rosae Rugosae 6-12, Radix Notoginseng powder 3-6, Radix Astragali 10-25, Radix Codonopsis 10-15, Rhizoma Atractylodis Macrocephalae 9-12, Ramulus Cinnamomi 3-6, Radix Paeoniae Alba 10-15, Rhizoma Coptidis 6-10, Fructus Evodiae 2-4, Concha Arcae (calcined) 10-15, Endoconcha Sepiae 6-12, Fructus Aurantii 9-15, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-15, Rhizoma Dioscoreae 20-30, Herba Taraxaci 10-20, Semen Arecae 6-10, Radix Glycyrrhizae 3-6.
The optimum weight of Chinese medicine preparation of the present invention (part) proportioning is:
Aspongopus 9, Flos Rosae Rugosae 10, Radix Notoginseng powder 6, the Radix Astragali 20, Radix Codonopsis 10, the Rhizoma Atractylodis Macrocephalae 10, Ramulus Cinnamomi 6, the Radix Paeoniae Alba 15, Rhizoma Coptidis 9, Fructus Evodiae 3, Concha Arcae (calcined) 15, Endoconcha Sepiae 10, Fructus Aurantii 9, Pseudobulbus Bletillae (Rhizoma Bletillae) 15, Rhizoma Dioscoreae 25, Herba Taraxaci 15, Semen Arecae 9, Radix Glycyrrhizae 6.
The production method that above-mentioned each component is made Chinese medicine preparation of the present invention is:
It is raw material that a takes by weighing Aspongopus, Flos Rosae Rugosae, Radix Notoginseng powder, the Radix Astragali, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Ramulus Cinnamomi, the Radix Paeoniae Alba, Rhizoma Coptidis, Fructus Evodiae, Concha Arcae (calcined), Endoconcha Sepiae, Fructus Aurantii, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Dioscoreae, Herba Taraxaci, Semen Arecae, Radix Glycyrrhizae 18 flavor Chinese medicines respectively according to above-mentioned weight proportion;
B chooses Aspongopus, Flos Rosae Rugosae, Radix Notoginseng powder, Pseudobulbus Bletillae (Rhizoma Bletillae), the Endoconcha Sepiae after the weighing, and pulverize separately becomes 120-200 order fine powder, sieves, mixing, obtains standby material one;
C decocts with water secondary with remaining 13 flavor Chinese medicines, and 1.5-2 hour for the first time, 1-1.5 hour for the second time, collecting decoction filters, and in temperature is under 60 ℃ the condition, to become relative density be the thick paste of 1.2-1.3 to concentrating under reduced pressure, cold drying is ground into 120-200 order fine powder, obtains standby material two;
D is with standby material one and standby material two mix homogeneously, and oven dry is sterilized, and is ground into 200 order fineness again, incapsulates (0.3-0.5 gram/grain), promptly gets medicament of the present invention.
Useful technique effect of the present invention is:
The present invention has the effect of warming middle-JIAO and strengthening the spleen, regulating qi-flowing for harmonizing stomach, blood-activating analgetic, gastralgia, the pantothenic acid that HP dependency chronic gastritis is caused especially, and symptoms such as singultus belch, indigestion and loss of appetite weak, yellowish complexion have unique curative effect.By clinical and pharmacological research in recent years, this product can be removed helicobacter pylori, promoting tissue regeneration and ulcer healing, the healing of promotion pathological changes mucosa, have easy absorption, rapid-action, pain palliation efficacy good, cure rate is high, relapse rate is low, cheap, advantage such as have no side effect, and prescription rationally, taking convenience has been opened up a new way in pure treatment by Chinese herbs HP dependency chronic gastritis.
The present invention chooses Aspongopus, Flos Rosae Rugosae, and Radix Notoginseng powder, the Radix Astragali, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Ramulus Cinnamomi, the Radix Paeoniae Alba, Rhizoma Coptidis, Fructus Evodiae, Concha Arcae (calcined), Endoconcha Sepiae, Fructus Aurantii, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Dioscoreae, Herba Taraxaci, Semen Arecae, the Radix Glycyrrhizae kinds of traditional Chinese medicines is made Chinese medicinal capsule, wherein, Aspongopus: salty in the mouth, temperature.Return the liver,spleen,kidney warp.Has regulating QI to relieve pain, the supporing yang effect of warming middle-JIAO.Be used for the cold syndrome of the stomach distending pain, stomachache due to hyperactive liver-QI attacking the stomach etc., Compendium of Material Medica claim it to cure mainly the stagnant gas of intestinal gastral cavity.Flos Rosae Rugosae: sweet in the mouth, little hardship, temperature.Return liver, spleen channel.Have promoting QI circulation for relieving depression, and blood, the pain relieving effect.Be used for stomachache due to hyperactive liver-QI attacking the stomach, the lack of appetite vomiting and nausea, chest and diaphragm is full vexed, gastral cavilty, the pain over the hypochondriac region etc.Modern pharmacological research is thought can improve the stomach blood circulation.Radix Notoginseng powder: sweet in the mouth, little hardship, temperature.Return liver, stomach warp.Effect with dissipating blood stasis hemostasis, subduing swelling and relieving pain.Diseases such as various hemorrhage hemostasis and the twinge of breast abdomen gastral cavilty portion such as be used for hematemesis, have blood in stool.The Radix Astragali: sweet in the mouth, temperature.Return lung, spleen channel.Have invigorating QI to consolidate the body surface resistance, the expelling pus and promoting granulation function, it is weak to be used for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea is had blood in stool, diseases such as deficiency of vital energy blood deficiency.Radix Codonopsis: sweet in the mouth is flat.Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting function.Be used for deficiency of the spleen and lung, anorexia and loose stool, gastropathy prolonged deficiency.The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, temperature.Return spleen, stomach warp.Has invigorating the spleen and benefiting QI, effects such as stomach function regulating dampness.Be used for insufficiency of the spleen lack of appetite, stomachache abdominal distention etc.Ramulus Cinnamomi: acrid in the mouth, sweet, temperature.GUIXIN, lung, urinary bladder channel.Have the diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat qigong of spining is imitated, and can be used for gastral cavilty and abdominal part cold type of pain.The Radix Paeoniae Alba: bitter in the mouth, acid are slightly cold.Return liver, spleen channel.The suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating, it is dizzy to be used to have a headache, hypochondriac pain, stomachache, stomachache, blood deficiency and yellow complexion.Rhizoma Coptidis: bitter in the mouth, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Has heat clearing and damp drying, eliminating fire and detoxication function, the effect of stomach function regulating preventing or arresting vomiting.Be used for cold and heat and tie mutually, damp and hot middle resistance, feeling of fullness vomiting, incoordination between the liver and stomach, vomiting acid regurgitation.Be usually used in various gastropathy, and the aid digestion effect that is good for the stomach is arranged.Fructus Evodiae: acrid in the mouth, hardship, heat; Slightly poisonous.Return liver, spleen, stomach, kidney channel.But dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.Be used for colic of cold type stomachache, gastral cavity abdomen account pain, vomiting acid regurgitation, disease such as have loose bowels just before dawn.The Rhizoma Coptidis Fructus Evodiae share, name Zuojin Wan, effect pungent drugs can disperse and bitter drugs can descend, regulating the stomach and sending down the abnormal ascending QI.Modern pharmacology research thinks that Rhizoma Coptidis has the effect of killing helicobacter pylori, and Fructus Evodiae has gastritis gastric ulcer, the effect of emesis antidiarrheal.Concha Arcae (calcined): salty in the mouth is flat.Return lung, stomach, Liver Channel.But the expectorant blood stasis dispelling, relieving gastric hyperacidity to alleviate stomachache.Be used to the pantothenic acid etc. of having a stomachache.Endoconcha Sepiae: salty in the mouth, puckery, temperature.Return spleen, kidney channel.Has astringing to arrest bleeding, the effect of antacid.Be used to the acid regurgitation of having a stomachache, spit blood ulcer class disease etc.Fructus Aurantii: bitter in the mouth, suffering, acid, temperature.Return spleen, stomach warp.Regulating the flow of QI to ease the stomach, effects such as the stagnant detumescence of row.Be used for the breast side of body stagnation of QI, flatulence pain, accumulation of food in the stomach and intes tine due to indigestion stops in the phlegm retention; Gastroptosis etc.Pseudobulbus Bletillae (Rhizoma Bletillae): bitter in the mouth, sweet, puckery is slightly cold.Return lung, liver, stomach warp.Has astringing to arrest bleeding, the detumescence and promoting granulation effect.Be used to the hematemesis of spitting blood, curing gastritis and ulcers is sick hemorrhage etc.Rhizoma Dioscoreae: sweet in the mouth, flat.Return spleen, lung, kidney channel.Has spleen reinforcing nourishing the stomach effect.Be used for insufficiency of the spleen lack of appetite, incessant chronic diarrhea etc., and the effect of protecting gastric mucosa is arranged.Herba Taraxaci: bitter in the mouth, sweet, cold.Return liver, stomach warp.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, and digestion promoting function is arranged.Be usually used in the treatment of stomach illness in recent years.Semen Arecae: bitter in the mouth, suffering, temperature.Return stomach, large intestine channel.Killing insect and eliminating accumulation is arranged, sending down the abnormal ascending QI, effects such as row water.Be usually used in gastralgia, stagnation of QI food stagnation.Radix Glycyrrhizae: sweet in the mouth is flat.GUIXIN, lung, spleen, stomach warp.Has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, gastralgia, cushion toxicity etc.
Be elaborated below by the treatment situation of several groups of cases therapeutic effect to this Chinese medicine preparation:
One, the king so-and-so, the man, 67 years old, the retired cadre suffered from surplus the gastropathy 30 year, often vague epigastralgia, gastral cavilty distension, belch pantothenic acid after meal.Tongue fur is white, stringy pulse.Gastroscopy is diagnosed as chronic superficial gastritis, and HP detects positive.Take Chinese medicine preparation capsule of the present invention, day clothes three times, each three (0.4 gram/grain), and symptom alleviates gradually after the week, and original symptom disappears substantially after 60 days, and gastroscope check gastric mucosal lesion recovers normal, and HP detects negative, follows up a case by regular visits to the several years and does not see recurrence.
Two, Liu so-and-so, man, 53 years old, the taxi driver, suffered from gastropathy existing more than 10 year, because work fatigue and diet are irregular, the state of an illness increases the weight of gradually in recent years, the gastral cavilty twinge of feed back, melena appears in feeling of distension and oppression discomfort recently, looks into the purplish tongue hesitant pulse, the gastroscopy prompting: the companion is hemorrhage for erosive gastritis, and HP detects positive.Take Chinese medicine preparation capsule of the present invention, day clothes three times, each three (0.5 gram/grain), symptom obviously alleviates after 10 days, active gastritis transference cure on the 50th, and gastroscopy mucosa pathological changes is clearly better, helicobacter pylori detects negative, treat and recovers after 3 months normally, follows up a case by regular visits to the several years not recur.
Three, Zhang, the woman, 49 years old, the patient did not have rule because of life in the time of 20 years old, suffered from chronic gastritis, and the state of an illness increased the weight of gradually in recent years, the gastralgia desire for warm and being pressed, pantothenic acid is scorching hot, and often melena occurs, anemia, cold extremities is weak, the light red tongue weak pulse.The gastroscopy prompting: chronic atrophic gastritis companion gastric ulcer, HP detects positive.Take Chinese medicine preparation capsule of the present invention, day clothes three times, each three (0.45 gram/grain), and symptom alleviated gradually on 60th, and appetite increases, the stool rule, the fecal occult blood feminine gender, the mental status takes a turn for the better.The gastroscope check, gastric mucosa inflammation pathological changes is recovered substantially, and the gastric ulcer face is clearly better, and gastritis transference cure, HP are checked negative.
In order further to show the therapeutic effect of Chinese medicine preparation of the present invention, the applicant has carried out the clinical research of system to 152 routine helicobacter pylori concerned chronic gastritis patients.
This group case is the totally 152 examples Qingdao City Huang Island institute of traditional Chinese medicine Digestive System Department of all originating, diagnostic criteria: tcm diagnosis is according to " disease of tcm diagnosis criterion of therapeutical effect ", and Western medicine diagnose is according to " common disease diagnosis basis and curative effect judging standard ".Be specially: (1) has gastral cavilty portion distending pain, burn feeling or twinge, upper digestive tract symptoms such as pantothenic acid, singultus.(2) gastric mucosa congestion edema, petechia, rotten to the corn point are found in gastroscopy.(3) stomach and mucosa and gastric juice urease fast diagnose test paper test positive (being that HP detects the positive).
Above-mentioned 152 examples are diagnosed as the helicobacter pylori concerned chronic gastritis case, are divided into treatment group 83 example and matched group 69 examples at random.
83 examples are organized in treatment: wherein male 54 examples, women 29 examples, age 17-64 year, course of disease 1-3 31 examples, 52 examples more than 3 years.Therapeutic Method: all medicines of stopping using, take medicine of the present invention, every day 3 times, each three (0.3-0.5 gram/grain), treating 30 days is a course of treatment, gastroscope of check and HP reagent paper testing experiment after each course of treatment.
Matched group 69 examples: wherein male 47 examples, women 22 examples, age 19-66 year, course of disease 1-3 21 examples, 48 examples more than 3 years.Therapeutic Method: all medicines of stopping using, take following Drug therapy: ampicillin capsule, each 0.5g, every day 3 times; Each 160,000 units of gentamycin sulfate tablets, every day 3 times; The each 1g of thiosugar aluminium flake, every day 3 times; The each 0.15g of ranitidine sheet, every day 2 times.30 days is a course of treatment, gastroscope of check and HP reagent paper testing experiment after each course of treatment.
Two groups of patients' sex, age, the course of disease distribute and compare, and learn processing difference by statistics and do not have significance (P>0.05), have comparability.Therapeutic outcome is analyzed with statistical method: adopt two sample mean t checks and paired t-test, Ridit check, X 2Check and rectilinear correlation analysis.The explanation of therapeutic effect following table:
Table 1
Table 1 for take Drug therapy of the present invention after 2 courses of treatment clinical cardinal symptom and curative effect relatively, treatment group and matched group comparison total effective rate have significant difference (P<0.05) in the table, the curative effect comparison all has higher curative effect for two groups, the treatment group is apparently higher than contrast groups.
Table 2
Table 2 for take Drug therapy of the present invention after 2 courses of treatment gastroscopy change relatively, treatment group and contrast groups comparison effective percentage, cure rate all have significant difference (P<0.05), two groups all have higher curative effect, the treatment group is apparently higher than contrast groups.
Table 3
Table 3 for take Drug therapy of the present invention after 3 courses of treatment HP removing situation relatively, 1,2,3 months HP clearance rate of treatment group and contrast groups comparison have significant difference (P<0.05), the curative effect comparison all has higher curative effect for two groups, the treatment group is apparently higher than contrast groups.
In sum, more than use medicine of the present invention 83 routine gastritis sufferers are done the treatment observation, obtain significant curative effect, and Liver and kidney cardiac function and blood biochemical, defecation are checked before and after the treatment, all do not find obvious toxic-side effects, drug administration safety of the present invention is described, to human body nonhazardous effect.
The specific embodiment
Embodiment 1
Take by weighing raw material by following proportioning:
Aspongopus 10 grams, Flos Rosae Rugosae 10 grams, Radix Notoginseng powder 6 grams, the Radix Astragali 20 grams, Radix Codonopsis 15 grams, the Rhizoma Atractylodis Macrocephalae 12 grams, Ramulus Cinnamomi 3 grams, the Radix Paeoniae Alba 15 grams, Rhizoma Coptidis 10 grams, Fructus Evodiae 3 grams, Concha Arcae (calcined) 15 grams, Endoconcha Sepiae 9 grams, Fructus Aurantii 15 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 15 grams, Rhizoma Dioscoreae 25 grams, Herba Taraxaci 15 grams, Semen Arecae 6 grams, Radix Glycyrrhizae 6 grams.
Production method is as follows:
Aspongopus after will taking by weighing earlier, Flos Rosae Rugosae, Radix Notoginseng powder, Pseudobulbus Bletillae (Rhizoma Bletillae), Endoconcha Sepiae pulverize separately become fine powder, all cross 120 mesh sieves then, and mixing obtains standby material one.Then with remaining 13 flavor Chinese medicines, decoct with water secondary, 1.5 hours for the first time, 1 hour for the second time, collecting decoction filtered, collect filtrate and with its under 60 ℃ of conditions, to become relative density be 1.3 thick paste to concentrating under reduced pressure, drying is 1 hour under 5 ℃, is ground into 120 order fine powders then, obtains standby material two.With above-mentioned standby material one and standby material two mix homogeneously, oven dry, sterilization is ground into 200 order fineness again, incapsulates (0.5 gram/grain), promptly gets medicament of the present invention.
Embodiment 2
Take by weighing raw material by following proportioning:
Aspongopus 6 grams, Flos Rosae Rugosae 10 grams, Radix Notoginseng powder 9 grams, the Radix Astragali 20, Radix Codonopsis 10 grams, the Rhizoma Atractylodis Macrocephalae 10 grams, Ramulus Cinnamomi 3 grams, the Radix Paeoniae Alba 12 grams, Rhizoma Coptidis 9 grams, Fructus Evodiae 3 grams, Concha Arcae (calcined) 15 grams, Endoconcha Sepiae 10 grams, Fructus Aurantii 12 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 15 grams, Rhizoma Dioscoreae 20 grams, Herba Taraxaci 10 grams, Semen Arecae 6 grams, Radix Glycyrrhizae 6 grams.
Production method is as follows:
Aspongopus after will taking by weighing earlier, Flos Rosae Rugosae, Radix Notoginseng powder, Pseudobulbus Bletillae (Rhizoma Bletillae), Endoconcha Sepiae pulverize separately become fine powder, all cross 160 mesh sieves then, and mixing obtains standby material one.Then with remaining 13 flavor Chinese medicines, decoct with water secondary, 1.7 hours for the first time, 1.2 hours for the second time, collecting decoction filtered, collect filtrate and with its under 60 ℃ of conditions, to become relative density be 1.3 thick paste to concentrating under reduced pressure, drying is 2 hours under 10 ℃, is ground into 120 order fine powders then, obtains standby material two.With above-mentioned standby material one and standby material two mix homogeneously, oven dry, sterilization is ground into 200 order fineness again, incapsulates (0.45 gram/grain), promptly gets medicament of the present invention.
Embodiment 3
Take by weighing raw material by following proportioning:
Aspongopus 9 grams, Flos Rosae Rugosae 6 grams, Radix Notoginseng powder 9 grams, the Radix Astragali 20 grams, Radix Codonopsis 12 grams, the Rhizoma Atractylodis Macrocephalae 10 grams, Ramulus Cinnamomi 9 grams, the Radix Paeoniae Alba 12 grams, Rhizoma Coptidis 6 grams, Fructus Evodiae 3 grams, Concha Arcae (calcined) 15 grams, Endoconcha Sepiae 6 grams, Fructus Aurantii 6 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 grams, Rhizoma Dioscoreae 20 grams, Herba Taraxaci 10 grams, Semen Arecae 6 grams, Radix Glycyrrhizae 6 grams.
Production method is as follows:
Aspongopus after will taking by weighing earlier, Flos Rosae Rugosae, Radix Notoginseng powder, Pseudobulbus Bletillae (Rhizoma Bletillae), Endoconcha Sepiae pulverize separately become fine powder, all cross 200 mesh sieves then, and mixing obtains standby material one.Then with remaining 13 flavor Chinese medicines, decoct with water secondary, 2 hours for the first time, 1.5 hours for the second time, collecting decoction filtered, collect filtrate and with its under 60 ℃ of conditions, to become relative density be 1.2 thick paste to concentrating under reduced pressure, drying is 1 hour under 15 ℃, is ground into 200 order fine powders then, obtains standby material two.With above-mentioned standby material one and standby material two mix homogeneously, oven dry is ground into 200 order fineness again, incapsulates (0.4 gram/grain), promptly gets medicament of the present invention.

Claims (4)

1. Chinese medicine preparation for the treatment of helicobacter pylori concerned chronic gastritis is characterized in that it is to be made by the following weight proportion raw material:
Aspongopus 3-12, Flos Rosae Rugosae 3-15, Radix Notoginseng powder 3-10, Radix Astragali 10-30, Radix Codonopsis 6-15, Rhizoma Atractylodis Macrocephalae 6-12, Ramulus Cinnamomi 3-10, Radix Paeoniae Alba 6-15, Rhizoma Coptidis 6-10, Fructus Evodiae 2-4, Concha Arcae (calcined) 10-20, Endoconcha Sepiae 6-15, Fructus Aurantii 6-15, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20, Rhizoma Dioscoreae 10-30, Herba Taraxaci 10-30, Semen Arecae 6-15, Radix Glycyrrhizae 3-10.
2. the Chinese medicine preparation of treatment helicobacter pylori concerned chronic gastritis according to claim 1, wherein the weight proportion of each raw material is:
Aspongopus 6-10, Flos Rosae Rugosae 6-12, Radix Notoginseng powder 3-6, Radix Astragali 10-25, Radix Codonopsis 10-15, Rhizoma Atractylodis Macrocephalae 9-12, Ramulus Cinnamomi 3-6, Radix Paeoniae Alba 10-15, Rhizoma Coptidis 6-10, Fructus Evodiae 2-4, Concha Arcae (calcined) 10-15, Endoconcha Sepiae 6-12, Fructus Aurantii 9-15, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-15, Rhizoma Dioscoreae 20-30, Herba Taraxaci 10-20, Semen Arecae 6-10, Radix Glycyrrhizae 3-6.
3. the Chinese medicine preparation of treatment helicobacter pylori concerned chronic gastritis according to claim 2, wherein the weight proportion of each raw material is:
Aspongopus 9, Flos Rosae Rugosae 10, Radix Notoginseng powder 6, the Radix Astragali 20, Radix Codonopsis 10, the Rhizoma Atractylodis Macrocephalae 10, Ramulus Cinnamomi 6, the Radix Paeoniae Alba 15, Rhizoma Coptidis 9, Fructus Evodiae 3, Concha Arcae (calcined) 15, Endoconcha Sepiae 10, Fructus Aurantii 9, Pseudobulbus Bletillae (Rhizoma Bletillae) 15, Rhizoma Dioscoreae 25, Herba Taraxaci 15, Semen Arecae 9, Radix Glycyrrhizae 6.
4. the preparation method of the Chinese medicine preparation of treatment helicobacter pylori concerned chronic gastritis according to claim 1 is characterized in that may further comprise the steps:
It is raw material that a takes by weighing Aspongopus, Flos Rosae Rugosae, Radix Notoginseng powder, the Radix Astragali, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Ramulus Cinnamomi, the Radix Paeoniae Alba, Rhizoma Coptidis, Fructus Evodiae, Concha Arcae (calcined), Endoconcha Sepiae, Fructus Aurantii, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Dioscoreae, Herba Taraxaci, Semen Arecae, Radix Glycyrrhizae 18 flavor Chinese medicines respectively according to above-mentioned weight proportion;
B chooses Aspongopus, Flos Rosae Rugosae, Radix Notoginseng powder, Pseudobulbus Bletillae (Rhizoma Bletillae), the Endoconcha Sepiae after the weighing, and pulverize separately becomes 120-200 order fine powder, sieves, mixing, obtains standby material one;
C decocts with water secondary with remaining 13 flavor Chinese medicines, and 1.5-2 hour for the first time, 1-1.5 hour for the second time, collecting decoction filters, and in temperature is under 60 ℃ the condition, to become relative density be the thick paste of 1.2-1.3 to concentrating under reduced pressure, cold drying is ground into 120-200 order fine powder, obtains standby material two;
D is with standby material one and standby material two mix homogeneously, and oven dry is sterilized, and is ground into 200 order fineness again, incapsulates, and 0.3-0.5 gram/grain promptly gets Chinese medicine preparation.
CN2010102160488A 2010-07-01 2010-07-01 Chinese medicinal preparation for treating helicobacter pylori concerned chronic gastritis and preparation method thereof CN101874874B (en)

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CN103211949B (en) * 2013-04-26 2017-02-22 吴起清 Traditional Chinese medicine composition for treating gastric diseases of human body as well as preparation method and application thereof
CN103330877B (en) * 2013-05-27 2015-03-25 陈松 Traditional Chinese medicine for treating atrophic gastritis
CN103330839B (en) * 2013-05-28 2015-03-04 吴艾潼 Traditional Chinese medicine for treating chronic gastritis
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