CN103169923B - Traditional Chinese medicine composition for treating myocarditis and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating myocarditis and preparation method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating myocarditis. The traditional Chinese medicine composition mainly comprises platycladi seeds, fructus forsythiae, astragalus, juncus effusus, safflower, cassia twig, radix ophiopogonis, radix curcumae, radix pseudostellariae, trichosanthis, lophatherum gracile, rhizoma arisaematis, radix glycyrrhizae preparate, cortex albiziae, shizandra and salvia miltiorrhiza. The traditional Chinese medicine composition has the effects of clearing away heat and toxic materials as well as warming the middle warmer and tonifying qi, has a favorable relaxation effect for symptoms such as chest distress, palpitate, dizzy giddy and short breath caused by myocarditis and has a remarkable therapeutic effect for myocarditis.
Description
Technical field
The invention discloses a kind of Chinese medicine composition, especially treat myocarditic Chinese medicine composition and preparation method thereof.The invention belongs to Chinese medicine field.
Background technology
Myocarditis refers in cardiac muscle, have limitation or diffuse acute, subacute or chronic inflammatory lesion.The relative incidence rate of viral myocarditis constantly increases in recent years.State of an illness weight is different, shows widely differently, and how heavier the infant state of an illness is, and much lighter adult is, and the lighter can be without obvious condition of illness, and severe one can concurrent severe arrhythmia, and cardiac insufficiency is even died suddenly.The prodrome of acute stage or subacute stage myocarditis, patient can have heating, tired, hyperhidrosis, nervous, out of breath, precordial fullness pain etc.Check the arrhythmia such as visible premature beat, conduction block, glutamic oxaloacetic transaminase, GOT, atrophy accompanied by elevation of CK, erythrocyte sedimentation rate speeds.Myocarditis can be primary in cardiac muscle, also a part for systemic disease.Myocarditis clinical symptoms: 1. symptom: tired, heating, uncomfortable in chest, cardiopalmus, breathe hard, dizziness, can there is cardiac insufficiency or cardiogenic shock in severe patient; 2. sign: increased heart rate, disproportionate ，Xin circle expands with fervescence, and noise changes, arrhythmia.
Myocarditic classification has: viral myocarditis, Children Myocarditis, hypertrophy myocarditis, toxic myocarditis, dilated myocarditis, parasitic myocarditis, bacterial infection myocarditis.
Viral myocarditis: pathogenic factor can cause by multiple viral infection, wherein the most common with Coxsackie virus B, chickenpox, Epstein-Barr virus also can cause.According to the study, can involve heart generation myocarditis after approximately having 5% viral infection person to infect.Can be the direct invasion and attack cardiac muscle after viral infection, also can be due to the autoimmune response after viral infection, the former is common with child, and the latter is common with teenager, and be the season occurred frequently of viral myocarditis spring.Its clinical symptoms just has upper respiratory tract infection or intestinal infection symptom for sick, occurs the symptoms such as uncomfortable in chest, cardiopalmus, extremely weak, easy perspiration after 7～10 days.Now, as have an electro-cardiogram, may find that there is the arrhythmias such as premature beat and cardiac damage performance.Making erythrocyte sedimentation rate, myocardium enzyme measures and may raise.2-4 looks into Coxsackie virus antibody after week, antimyocardial antibody can be positive.
Children Myocarditis: Children Myocarditis patient, often first develop signs of a cold, as fever, cough, pharyngalgia, watery nasal discharge, general malaise, nausea and vomiting, stomachache, diarrhoea, some also has arthralgia, myalgia.These symptoms take a turn for the better gradually or disappear at leisure, and the sign of heart abnormality starts to occur: palpitating speed or obviously slow down, or occur stopping fighting, irregular.Baby's lethargy, green around the gills, unable, hyperhidrosis, inappetence or repeatedly occur nausea and vomiting, epigastrium pain; Or tell headache, dizziness, cardiopalmus, uncomfortable in chest, pareordia is uncomfortable or pain.The performance of the cardiac dysfunctions such as severe patient is also shown in face edema, it is sleeping to put down, tachypnea.It is slack-off that some baby understands unexpected heart beating, and per minute only have 20～30 times, caused acute cerebral ischemia, causes convulsion outbreak or unexpected generation, directly threatens life.
Hypertrophy myocarditis: myocardial cell has had defect, heart wall can chap.Serious in the situation that, the heart wall of enlargement may hinder blood and flows to and flow out heart.This disease is just hypertrophic cardiomyopathy.Its symptom is prone to the phenomenons such as tired, chest pain, tachypnea and cardiopalmus for suffering from the myocarditic patient of hypertrophy.
Toxic myocarditis: refer to the myocardial inflammation due to toxin or poisonous substance, except the infectious disease extracellular toxins such as diphtheria, typhoid fever, bacillary dysentery, endotoxin on myocardial infringement, some biotoxin is as snake venom, poisonous fungus, Fugu ocellatus, Aconitum carmichjaelii Debx. etc., and some drugs or chemical substance are as quinidine, quinine, emetine, antimony agent, organophosphor, organic mercury, arsenic, carbon monoxide, lead, Ah enzyme's element etc., all can cause that cardiac damage produces toxic myocarditis.The toxic myocarditis poisoning a part of important behaviour of whole body often, the critical or concurrent severe cardiac functional defect of the state of an illness and arrhythmia person's mortality rate are high, in time, effectively rescue and often can save patients ' lives.Its symptom and sign is: 1. the symptom of cardiac insufficiency, as cardiopalmus, breathe hard, body and pulmonary circulation blood stasis sign; 2. ARR performance.
Dilated myocarditis: dilated myocarditis heart often increases, cardiac dilatation is the most obvious with bilateral ventricle, thereby claims dilated myocarditis; dilatation of heart is compared with the lighter, and ventricle wall slightly thickens, pathological development; expansion increases the weight of, the relative attenuation of ventricle wall, and ventricle wall thickness normally or slightly thickens.Due to myocardial fibrosis, amyocardia, ejection fraction declines, and semilunar valve mouth may occur that function is narrow, left and right ventricles expansion, can cause AO relative incompetence, blood flow repeated stock causes chamber valve and slightly thickens, and cardiomyopathy can extend to endocardium, and the local blood supply insufficiency of the rising of intracardiac local pressure, can cause endocardium speckle shape fibrous thickening, approximately 60% case has mural thrombus to form.
Parasitic myocarditis common are following two types: 1. toxoplasma myocarditis.This kind of myocarditis is caused by infection by Toxoplasma gondii.The mankind mainly infect because eating the meat that do not boil that contains encapsulation.Toxoplasma enters after human body, and menses flow to and reach mononuclear phagocyte system and various tissue, and breed in cell.Toxoplasma is bred after invading myocardial cell very soon, forms aggregation, also claims pseudocyst.Myocardial cell breaks very soon, and pathogen enters surrounding tissue.Destroyed myocardial cell has lymphocyte, monocyte infiltration around.After more multiple, there is cicatrization.About half patient because of heart failure lethal; 2.Chagas myocarditis.This kind of myocarditis infected and caused by protozoon Ku Shi trypanosomicide, is popular in various countries, Latin America.Be in a bad way, mortality rate is high.Can cause kitchen range shape or dispersivity myocardial necrosis, have lymphocyte, monocyte infiltration around.Dilatation of heart, ventricle wall (mainly in apical region of heart) attenuation, often forms ventricular aneurysm, with the included wall thrombosis of the chambers of the heart.
Bacterial myocarditis: some myocarditis can be by antibacterial direct infection, or bacteriogenic toxin is to myocardium effect, or the allergy due to bacterial product and causing: 1. abscess,myocardial is often caused by suppuration bacterium, as staphylococcus, streptococcus, Diplococcus pneumoniae, meningococcus etc.Transitivity bacterial clump when suppuration bacterium derives from pyaemia septica, or the suppurative Thromboembolus during from bacterial endocarditis.Naked eyes are seen, and the visible multiple yellow microabscess of heart surface and tangent plane has congested band around.Under mirror, abscess myocardium necrocytosis liquefaction, has a large amount of pus cells and quantity antibacterial colony not etc. in vomica.Abscess around cardiac muscle has degeneration, necrosis in various degree, has neutrophilic granulocyte and monocyte infiltration in interstitial; 2. diphtheria corynebacterium can produce extracellular toxin, the protein synthesis of one side myocardial cell ribosome capable of blocking, and the long-chain fatty acid of carnitine mediation capable of blocking is transported into mitochondrion on the other hand, causes myocardial cell steatosis and necrosis.Under mirror, visible kitchen range shape muscular degeneration of heart is downright bad, and myocardial cell occurs that acidophile degeneration, sarcoplasm cohesion, steatosis and sarcoplasm dissolve.The visible lymphocyte of intralesional, mononuclear cell and minority neutrophil infiltration.Focus is more common in right ventricle wall, the more multiple rear little cicatrix of fine mesh that forms.There is diffusivity myocardial necrosis in some cases, can cause sudden cardiac death; 3. when upper respiratory tract streptococcal infection (acute angina, tonsillitis) and scarlet fever, can the non-rheumatic myocarditis of complicated with acute.Its pathogenesis is not yet clear, may be to be caused by streptococcus toxin.Pathological changes is interstitial myocarditis.Under mirror, in myocardium interstitial connective tissue and around little blood vessel, there are lymphocyte, monocyte infiltration, myocardial cell to have degeneration, the necrosis of varying degree.
Western medicine is also undesirable to myocarditis and myocardiac therapeutic effect at present.Concerning Patients with Viral Myocarditis, do not have specific antiviral drugs; Arrhythmia curative effect to chronic myocarditis patient is not good enough.Myocarditis and cardiomyopathy are a kind of diseases that endangers people ' s health and be difficult for treatment.From the curative effect of this class cardiomyopathy of in these years Chinese traditional treatment, situation is gratifying, and we can improve effective percentage at this class disease of traditional Chinese medical herbal treatment, reduces mortality rate, reduces sequela.To improving quality of life of patients, in doctor trained in Western medicine, there is obvious advantage.
The traditional Chinese medical science thinks, the myocarditic cause of disease is for experiencing wind-heat evil toxin, inside damages due to the heart.In the myocarditic Chinese medicine of existing treatment, Chinese patent CN1406616 discloses a kind of " viral myocarditis tablet " by name in 2003, by Chinese medicines such as Radix Isatidis, Folium Isatidis, the Rhizoma Atractylodis Macrocephalae, river a kind of reed mentioned in ancient books, Semen Ziziphi Spinosae, Flos Lonicerae, Radix Bupleuri, Radix Ophiopogonis, formed, its therapeutic effect is single, only, for viral myocarditis, cannot accomplish the comprehensive treatment to myocarditis one class disease.
Summary of the invention
For the present situation of existing treatment myocarditis curative effect deficiency, one of object of the present invention is to provide a kind of myocarditic Chinese medicine composition for the treatment of, and has feature evident in efficacy, and its adopts comparatively common in the localities Chinese crude drug as raw material, with low cost.
Another object of the present invention is just to provide the preparation method of above-mentioned Chinese medicine composition.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treat a myocarditic Chinese medicine composition, preferred scheme, takes off the primary raw material of stating weight proportion and is prepared from: Semen Platycladi 3-9 part, Fructus Forsythiae 6-15 part, Radix Astragali 9-30 part, Medulla Junci 1-3 part, Flos Carthami 3-9 part, Ramulus Cinnamomi 3-9 part, Radix Ophiopogonis 6-12 part, Radix Curcumae 3-9 part, Radix Pseudostellariae 9-30 part, Fructus Trichosanthis 9-15 part, Herba Lophatheri 6-9 part, Rhizoma Arisaematis 3-9 part, Radix Glycyrrhizae Preparata 1.5-9 part, Cortex Albiziae 6-12 part, Fructus Schisandrae Chinensis 1.5-6 part, Radix Salviae Miltiorrhizae 9-15 part.
Treat a myocarditic Chinese medicine composition, the scheme being more preferably, takes off the primary raw material of stating weight proportion and is prepared from: Semen Platycladi 5-8 part, Fructus Forsythiae 8-12 part, Radix Astragali 12-25 part, Medulla Junci 1.5-2.5 part, Flos Carthami 5-8 part, Ramulus Cinnamomi 4-7 part, Radix Ophiopogonis 7-10 part, Radix Curcumae 5-7 part, Radix Pseudostellariae 15-25 part, Fructus Trichosanthis 10-13 part, Herba Lophatheri 7-8 part, Rhizoma Arisaematis 5-8 part, Radix Glycyrrhizae Preparata 3-6 part, Cortex Albiziae 8-10 part, Fructus Schisandrae Chinensis 3-5 part, Radix Salviae Miltiorrhizae 10-13 part.
Treat a myocarditic Chinese medicine composition, best scheme, takes off the primary raw material of stating weight proportion and is prepared from: 6 parts of Semen Platycladi, 10 parts of Fructus Forsythiaes, 20 parts of the Radixs Astragali, 2 parts of Medulla Juncies, 6 parts, Flos Carthami, 5 parts of Ramulus Cinnamomi, 8 parts of Radix Ophiopogonis, 6 parts of Radix Curcumaes, 20 parts of Radix Pseudostellariaes, 12 parts of Fructus Trichosanthis, 8 parts of Herba Lophatheris, 6 parts of Rhizoma Arisaematiss, 4 parts of Radix Glycyrrhizae Preparatas, 9 parts of Cortex Albiziaes, 4 parts of Fructus Schisandrae Chinensis, 12 parts of Radix Salviae Miltiorrhizaes.
The preparation process of above-mentioned Chinese medicine composition is as follows:
1. by Semen Platycladi, Fructus Forsythiae, the Radix Astragali, Medulla Junci, Flos Carthami, Ramulus Cinnamomi, Radix Ophiopogonis, Radix Curcumae, Radix Pseudostellariae, Fructus Trichosanthis, Herba Lophatheri, Rhizoma Arisaematis, Radix Glycyrrhizae Preparata, Cortex Albiziae, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae decocts with water 2 times, 2.0 hours for the first time, 1.5 hours for the second time, filtrate merging decocted 1 hour again, standing 20-30 hour, again filter, filter, it is 1.05 that filtrate is concentrated into relative density;
2. by step 1. gained filtrate add ethanol, ethanol consumption be filtrate quality 0.5-1.5 doubly, abundant mix homogeneously, standing cold preservation 30 hours, filters, and after filtrate recycling ethanol, then continues to be concentrated into thick paste, to relative density be 1.30-1.40;
3. get appropriate Icing Sugar and dry 1-2 hour in 60 ℃, be placed in appropriate vessel, add step 2. in gained thick paste stirring and evenly mixing, be modulated into soft durometer and be that hands is pinched is agglomerating, gently press loose soft material, soft material is crossed 10-14 mesh sieve, makes wet granular;
4. the wet granular bake drying of 3. step being made, baking temperature is 60 ℃-80 ℃, cooling rear sealing is stand-by.
The preparation method of above-mentioned Chinese medicine composition, step 1. standing 20-30 hour (preferred standing 22-28 hour is more preferably standing 25 hours), filters again.
The preparation method of above-mentioned Chinese medicine composition, step 2. ethanol consumption is 0.5-1.5 times (preferred alcohol consumption is 1.0 times of filtrate quality) of filtrate quality.
The preparation method of above-mentioned Chinese medicine composition, 2. step continues to be concentrated into thick paste again, to relative density be 1.30-1.40(preferably to relative density be 1.35).
The preparation method of above-mentioned Chinese medicine composition, step 3. soft material is crossed 10-14 mesh sieve (preferably soft material is crossed 12 mesh sieves), makes wet granular.
The preparation method of above-mentioned Chinese medicine composition, step 4. baking temperature is 60 ℃-80 ℃ (preferably baking temperature is 70 ℃).
Using method: for making Chinese medicine composition of the present invention reach optimum therapeuticing effect, every day twice, in 1 hour after meal sooner or later, get 10g, take after mixing it with hot water.
This Chinese medicine composition is remarkable to myocarditis effect, not only has heat-clearing and toxic substances removing, and comfortable effect of invigorating blood circulation, can also nurse one's health patient's health, for prolonged illness, causes lethargy, and look tired person has good medical treatment effect.Local common medical material for multiselect of the present invention, cheap, alleviated patient's financial burden.
The pharmacological effect of each crude drug is respectively:
Semen Platycladi: sweet in the mouth, property is flat.There is tranquilizing by nourishing the heart, hidroschesis, the effect of intestine moistening, for fidgets due to deficiency insomnia, severe palpitation, night sweat due to yin deficiency, dryness of the intestine constipation.
Fructus Forsythiae: bitter in the mouth, cold nature.There is heat-clearing and toxic substances removing, the effect of dispersing swelling and dissipating binds, for carbuncle, anemopyretic cold.Warm joining the army, high hot excessive thirst.
The Radix Astragali: sweet in the mouth, slightly warm in nature.Have benefiting QI for strengthening the superficies, arresting sweating is admittedly de-, and the effect of inducing diuresis to remove edema is weak for the deficiency of vital energy, sinking of QI of middle-JIAO, blood deficiency and yellow complexion.
Medulla Junci: sweet in the mouth, light, cold nature.Have clearing away heart-fire, the effect of diuresis, for vexed insomnia.The puckery pain of oliguria, aphtha of the mouth and tongue.
Flos Carthami: acrid in the mouth, warm in nature.There is promoting blood circulation to restore menstrual flow, the effect of eliminating stasis to stop pain, for amenorrhea, lochia, skin infection swells and ache.
Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature.There is diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, the effect of the flat gas that spins, for anemofrigid cold, edema, cardiopalmus.
Radix Ophiopogonis: sweet in the mouth, micro-hardship, cold nature.Have YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, for dryness of the lung dry cough, and cough due to consumptive disease, vexed insomnia, interior-heat is quenched one's thirst.
Radix Curcumae: acrid in the mouth, hardship, cold in nature.There is regulating qi to disperse stagnation, heart fire-clearing upset-relieving, the effect of promoting the function of the gallbladder to alleviate jaundice, for amenorrhea dysmenorrhea, chest and abdomen swelling and pain.
Radix Pseudostellariae: sweet in the mouth, micro-hardship, property is flat.There is replenishing QI to invigorate the spleen, the effect of promoting the production of body fluid for nourishing the lung, tired for insufficiency of the spleen body, inappetence is weak after being ill.
Fructus Trichosanthis: sweet in the mouth, micro-hardship, cold in nature.There is clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, the effect of moisturizing laxation, for cough due to lung-heat, obstruction of qi in the chest and cardialgia, lung abscess.
Herba Lophatheri: sweet in the mouth, light, cold in nature.There is clearing heat and relieving fidgetness, the effect of diuresis, for calentura excessive thirst, hot urination drenches pain, aphtha of the mouth and tongue.
Rhizoma Arisaematis: bitter in the mouth, pungent, warm in nature.There is drying dampness to eliminate phlegm, expelling wind and relieving convulsion, the effect of mass dissipating and swelling eliminating, for pertinacious phlegm cough, paralysis is dizzy, hemiplegia.
Radix Glycyrrhizae Preparata: sweet in the mouth, property are put down.There is spleen reinforcing stomach function regulating, the effect of Yiqi and vein recovery, for weakness of the spleen and stomach, tired state is weak, severe palpitation, irregularly intermittent and regularly intermittent pulse.
Cortex Albiziae: sweet in the mouth, property is flat.There is resolving stagnation for tranquilization, the effect of promoting blood circulation and detumescence, for irritability, resolving depression insomnia, lung abscess skin ulcer is swollen, falls and flutters the pain of injury.
Fructus Schisandrae Chinensis: sour in the mouth, sweet, warm in nature.There is convergence astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, the effect of kidney calming, coughs for chronic cough void, spontaneous perspiration, night sweat.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature.There is promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, the effect of nourishing blood to tranquillize the mind, for dysphoria and insomnia, costa sternales hypochondriac pain.
Chinese medicine composition of the present invention is based on the myocarditic principle of traditional Chinese medical herbal treatment.The medical material of selecting all has the effect of heat-clearing and toxic substances removing, for myocarditis determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, belongs to the prescription for the treatment of both the principal and secondary aspects of a disease.Myocarditis is had to fabulous therapeutical effect.
The specific embodiment
Below in conjunction with embodiment and experimental example, describe technical scheme of the present invention in detail, but protection domain is not by this restriction.
embodiment 1treat a myocarditic Chinese medicine composition, get following traditional Chinese medicine raw medicine: 3 grams of Semen Platycladi, 6 grams of Fructus Forsythiaes, 9 grams of the Radixs Astragali, 1 gram of Medulla Junci, 3 grams, Flos Carthami, 3 grams of Ramulus Cinnamomi, 6 grams of Radix Ophiopogonis, 3 grams of Radix Curcumaes, 9 grams of Radix Pseudostellariaes, 9 grams of Fructus Trichosanthis, 6 grams of Herba Lophatheris, 3 grams of Rhizoma Arisaematiss, 1.5 grams of Radix Glycyrrhizae Preparatas, 6 grams of Cortex Albiziaes, 1.5 grams of Fructus Schisandrae Chinensis, 9 grams of Radix Salviae Miltiorrhizaes.
The preparation method of above-mentioned Chinese medicine composition, step is:
1. by Semen Platycladi, Fructus Forsythiae, the Radix Astragali, Medulla Junci, Flos Carthami, Ramulus Cinnamomi, Radix Ophiopogonis, Radix Curcumae, Radix Pseudostellariae, Fructus Trichosanthis, Herba Lophatheri, Rhizoma Arisaematis, Radix Glycyrrhizae Preparata, Cortex Albiziae, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae decocts with water 2 times, 2.0 hours for the first time, 1.5 hours for the second time, filtrate merging decocted 1 hour again, standing 20 hours, again filter, filter, it is 1.05 that filtrate is concentrated into relative density;
2. by step 1. gained filtrate add ethanol, ethanol consumption is 0.5 times of filtrate quality, abundant mix homogeneously, standing cold preservation 30 hours, filters, and after filtrate recycling ethanol, then continues to be concentrated into thick paste, to relative density be 1.30;
3. get appropriate Icing Sugar and dry 1-2 hour in 60 ℃, be placed in appropriate vessel, add step 2. in gained thick paste stirring and evenly mixing, be modulated into soft durometer and be that hands is pinched is agglomerating, gently press loose soft material, soft material is crossed 10 mesh sieves, makes wet granular;
4. the wet granular bake drying of 3. step being made, baking temperature is 60 ℃, cooling rear sealing is stand-by.
5. preparation method according to claim 4, is characterized in that, step 1. standing 20-30 hour (preferred standing 22-28 hour is more preferably standing 25 hours) is filtered again.
6. preparation method according to claim 4, is characterized in that, step 2. ethanol consumption is 0.5-1.5 times (preferred alcohol consumption is 1.0 times of filtrate quality) of filtrate quality.
7. preparation method according to claim 4, is characterized in that, 2. step continues to be concentrated into thick paste again, to relative density be 1.30-1.40(preferably to relative density be 1.35).
8. preparation method according to claim 4, is characterized in that, step 3. soft material is crossed 10-14 mesh sieve (preferably soft material is crossed 12 mesh sieves), makes wet granular.
9. preparation method according to claim 4, is characterized in that, step 4. baking temperature is 60 ℃-80 ℃ (preferably baking temperature is 70 ℃).
model case oneappoint Gaoqing County, Zibo City, XX ，Nan ，25Sui， Shandong Province.Symptom: patient occurs palpitation and short breath at last spring after catching a cold, malaise, the symptom of easily perspiring, and it is viral myocarditis after diagnosing that movable rear symptom increases the weight of ，Qu hospital, and hospitalization takes a turn for the better, but within nearly one week, because of fatigue, recur, symptom is obviously serious than before, has also occurred uncomfortable in chest.Sick age: 1 year half.Examine the time: on July 26th, 2011; Take the granule that Chinese medicine composition of the present invention is made, get 10g at every turn and brew with boiled water, one day twice, every day, sooner or later within 1 hour after meal, take.Take 10 days, symptom uncomfortable in chest alleviates; Take 20 days, symptom uncomfortable in chest disappears completely, perspiration remission; Take 1 month, perspiration transference cure, palpitation and short breath symptom is obviously improved; Take 1 first quarter moon, palpitation and short breath transference cure, recovers.During taking Chinese medicine composition granule of the present invention, have no adverse reaction, drug withdrawal is so far without recurrence.
embodiment 2treat a myocarditic Chinese medicine composition, get following traditional Chinese medicine raw medicine: 5 grams of Semen Platycladi, 8 grams of Fructus Forsythiaes, 12 grams of the Radixs Astragali, 1.5 grams of Medulla Juncies, 5 grams, Flos Carthami, 4 grams of Ramulus Cinnamomi, 7 grams of Radix Ophiopogonis, 5 grams of Radix Curcumaes, 15 grams of Radix Pseudostellariaes, 10 grams of Fructus Trichosanthis, 7 grams of Herba Lophatheris, 5 grams of Rhizoma Arisaematiss, 3 grams of Radix Glycyrrhizae Preparatas, 8 grams of Cortex Albiziaes, 3 grams of Fructus Schisandrae Chinensis, 10 grams of Radix Salviae Miltiorrhizaes.
The preparation method of above-mentioned Chinese medicine composition, step is:
1. by Semen Platycladi, Fructus Forsythiae, the Radix Astragali, Medulla Junci, Flos Carthami, Ramulus Cinnamomi, Radix Ophiopogonis, Radix Curcumae, Radix Pseudostellariae, Fructus Trichosanthis, Herba Lophatheri, Rhizoma Arisaematis, Radix Glycyrrhizae Preparata, Cortex Albiziae, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae decocts with water 2 times, 2.0 hours for the first time, 1.5 hours for the second time, filtrate merging decocted 1 hour again, standing 22 hours, again filter, filter, it is 1.05 that filtrate is concentrated into relative density;
2. by step 1. gained filtrate add ethanol, ethanol consumption is 1.0 times of filtrate quality, abundant mix homogeneously, standing cold preservation 30 hours, filters, and after filtrate recycling ethanol, then continues to be concentrated into thick paste, to relative density be 1.35;
3. get appropriate Icing Sugar and dry 1-2 hour in 60 ℃, be placed in appropriate vessel, add step 2. in gained thick paste stirring and evenly mixing, be modulated into soft durometer and be that hands is pinched is agglomerating, gently press loose soft material, soft material is crossed 12 mesh sieves, makes wet granular;
4. the wet granular bake drying of 3. step being made, baking temperature is 70 ℃, cooling rear sealing is stand-by.
model case twoyuan XX, female, 5 years old, Lanshan District, Linyi.Symptom: patient's flu was deeply breathed by normal appearance, weak.After throwing off a cold, weak symptom does not disappear, lassitude always also, and dizziness, uncomfortable in chest, breathe hard and green around the gills ，Qu hospital is infantile viral myocarditis after diagnosing.Sick age: 1 year.Examine the time: on JIUYUE 17th, 2011; Take the granule that Chinese medicine composition of the present invention is made, get 10g at every turn and brew with boiled water, one day twice, every day, sooner or later within 1 hour after meal, take.Take 7 days, weak symptom is obviously improved; Take 15 days, weak, lassitude transference cure; Take 20 days, symptom uncomfortable in chest alleviates, dizzy transference cure; Take 1 month, uncomfortable in chest, the symptom of breathing hard disappears completely, recovers.During taking Chinese medicine composition granule of the present invention, have no adverse reaction, drug withdrawal is so far without recurrence.
embodiment 3treat a myocarditic Chinese medicine composition, get following traditional Chinese medicine raw medicine: 8 grams of Semen Platycladi, 12 grams of Fructus Forsythiaes, 25 grams of the Radixs Astragali, 2.5 grams of Medulla Juncies, 8 grams, Flos Carthami, 7 grams of Ramulus Cinnamomi, 10 grams of Radix Ophiopogonis, 7 grams of Radix Curcumaes, 25 grams of Radix Pseudostellariaes, 13 grams of Fructus Trichosanthis, 8 grams of Herba Lophatheris, 8 grams of Rhizoma Arisaematiss, 6 grams of Radix Glycyrrhizae Preparatas, 10 grams of Cortex Albiziaes, 5 grams of Fructus Schisandrae Chinensis, 13 grams of Radix Salviae Miltiorrhizaes.
The preparation method of above-mentioned Chinese medicine composition, step is:
1. by Semen Platycladi, Fructus Forsythiae, the Radix Astragali, Medulla Junci, Flos Carthami, Ramulus Cinnamomi, Radix Ophiopogonis, Radix Curcumae, Radix Pseudostellariae, Fructus Trichosanthis, Herba Lophatheri, Rhizoma Arisaematis, Radix Glycyrrhizae Preparata, Cortex Albiziae, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae decocts with water 2 times, 2.0 hours for the first time, 1.5 hours for the second time, filtrate merging decocted 1 hour again, standing 28 hours, again filter, filter, it is 1.05 that filtrate is concentrated into relative density;
2. by step 1. gained filtrate add ethanol, ethanol consumption is 1.0 times of filtrate quality, abundant mix homogeneously, standing cold preservation 30 hours, filters, and after filtrate recycling ethanol, then continues to be concentrated into thick paste, to relative density be 1.35;
3. get appropriate Icing Sugar and dry 1-2 hour in 60 ℃, be placed in appropriate vessel, add step 2. in gained thick paste stirring and evenly mixing, be modulated into soft durometer and be that hands is pinched is agglomerating, gently press loose soft material, soft material is crossed 12 mesh sieves, makes wet granular;
4. the wet granular bake drying of 3. step being made, baking temperature is 70 ℃, cooling rear sealing is stand-by.
embodiment 4treat a myocarditic Chinese medicine composition, get following traditional Chinese medicine raw medicine: 9 grams of Semen Platycladi, 15 grams of Fructus Forsythiaes, 30 grams of the Radixs Astragali, 3 grams of Medulla Juncies, 9 grams, Flos Carthami, 9 grams of Ramulus Cinnamomi, 12 grams of Radix Ophiopogonis, 9 grams of Radix Curcumaes, 30 grams of Radix Pseudostellariaes, 15 grams of Fructus Trichosanthis, 9 grams of Herba Lophatheris, 9 grams of Rhizoma Arisaematiss, 9 grams of Radix Glycyrrhizae Preparatas, 12 grams of Cortex Albiziaes, 6 grams of Fructus Schisandrae Chinensis, 15 grams of Radix Salviae Miltiorrhizaes.
The preparation method of above-mentioned Chinese medicine composition, step is:
1. by Semen Platycladi, Fructus Forsythiae, the Radix Astragali, Medulla Junci, Flos Carthami, Ramulus Cinnamomi, Radix Ophiopogonis, Radix Curcumae, Radix Pseudostellariae, Fructus Trichosanthis, Herba Lophatheri, Rhizoma Arisaematis, Radix Glycyrrhizae Preparata, Cortex Albiziae, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae decocts with water 2 times, 2.0 hours for the first time, 1.5 hours for the second time, filtrate merging decocted 1 hour again, standing 30 hours, again filter, filter, it is 1.05 that filtrate is concentrated into relative density;
2. by step 1. gained filtrate add ethanol, ethanol consumption is 1.5 times of filtrate quality, abundant mix homogeneously, standing cold preservation 30 hours, filters, and after filtrate recycling ethanol, then continues to be concentrated into thick paste, to relative density be 1.40;
3. get appropriate Icing Sugar and dry 1-2 hour in 60 ℃, be placed in appropriate vessel, add step 2. in gained thick paste stirring and evenly mixing, be modulated into soft durometer and be that hands is pinched is agglomerating, gently press loose soft material, soft material is crossed 14 mesh sieves, makes wet granular;
4. the wet granular bake drying of 3. step being made, baking temperature is 80 ℃, cooling rear sealing is stand-by.
model case threelee XX, man, 40 years old, Decheng District, Dezhou City Shandong Province.Symptom: patient has dilated myocarditis frequent sensation of oppression over the chest with shortness of breath for many years, and cardiopalmus is weak, dyspnea, abdominal distention, once in a while excited or some all can cause these symptoms tired time.Sick age: 5 years.Examine the time: on November 05th, 2011; Take the granule that Chinese medicine composition of the present invention is made, get 10g at every turn and brew with boiled water, one day twice, every day, sooner or later within 1 hour after meal, take.Take 15 days, sensation of oppression over the chest with shortness of breath remission, takes 20 days, and sensation of oppression over the chest with shortness of breath symptom disappears completely, and dyspnea takes a turn for the better; Take 1 month, breathe normally, abdominal distention disappears; Take 1 first quarter moon, cardiopalmus remission, weak transference cure; Take 2 months, cardiopalmus transference cure, every ill symptoms disappears completely, takes again Chinese medicine composition granule of the present invention and consolidate curative effect 10 days after recovering, and drug withdrawal is so far without recurrence.
embodiment 5treat a myocarditic Chinese medicine composition, get following traditional Chinese medicine raw medicine: 6 grams of Semen Platycladi, 10 grams of Fructus Forsythiaes, 20 grams of the Radixs Astragali, 2 grams of Medulla Juncies, 6 grams, Flos Carthami, 5 grams of Ramulus Cinnamomi, 8 grams of Radix Ophiopogonis, 6 grams of Radix Curcumaes, 20 grams of Radix Pseudostellariaes, 12 grams of Fructus Trichosanthis, 8 grams of Herba Lophatheris, 6 grams of Rhizoma Arisaematiss, 4 grams of Radix Glycyrrhizae Preparatas, 9 grams of Cortex Albiziaes, 4 grams of Fructus Schisandrae Chinensis, 12 grams of Radix Salviae Miltiorrhizaes.
The preparation method of above-mentioned Chinese medicine composition, step is:
1. by Semen Platycladi, Fructus Forsythiae, the Radix Astragali, Medulla Junci, Flos Carthami, Ramulus Cinnamomi, Radix Ophiopogonis, Radix Curcumae, Radix Pseudostellariae, Fructus Trichosanthis, Herba Lophatheri, Rhizoma Arisaematis, Radix Glycyrrhizae Preparata, Cortex Albiziae, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae decocts with water 2 times, 2.0 hours for the first time, 1.5 hours for the second time, filtrate merging decocted 1 hour again, standing 25 hours, again filter, filter, it is 1.05 that filtrate is concentrated into relative density;
2. by step 1. gained filtrate add ethanol, ethanol consumption is 1.0 times of filtrate quality, abundant mix homogeneously, standing cold preservation 30 hours, filters, and after filtrate recycling ethanol, then continues to be concentrated into thick paste, to relative density be 1.35;
3. get appropriate Icing Sugar and dry 1-2 hour in 60 ℃, be placed in appropriate vessel, add step 2. in gained thick paste stirring and evenly mixing, be modulated into soft durometer and be that hands is pinched is agglomerating, gently press loose soft material, soft material is crossed 12 mesh sieves, makes wet granular;
4. the wet granular bake drying of 3. step being made, baking temperature is 70 ℃, cooling rear sealing is stand-by.
Using method: for making Chinese medicine composition of the present invention reach optimum therapeuticing effect, every day twice, in 1 hour after meal sooner or later, get 10g, take after mixing it with hot water.
experimental example
In order to verify the effect of Chinese medicine composition of the present invention, we have extracted 150 patients and have carried out the experiment of medicine, are equally divided into two groups, every group of 75 people, experimental group and matched group, experimental group is used embodiment 5 gained Chinese medicine compositions, and matched group is taken other and is treated myocarditic Chinese medicine.
Inclusion criteria: through being diagnosed as patients with myocarditis, disease 1-5 in age, has myocarditis clinical symptoms one or more.
Curative effect situation criterion (contrasting with the data of taking 3 months): 1, cure.Drug administration 3 months, malaise symptoms disappears completely; 2, effective.Drug administration 3 months, malaise symptoms alleviates or part disappears; 3, invalid.Drug administration 3 months, malaise symptoms is unchanged.
We have carried out accurate statistics and mathematical analysis to experimental data.Specific experiment result is as following table:
Table 1: two groups of Clinical efficacy comparisons [example]
Result: two groups of Clinical efficacy comparisons, matched group total effective rate is 40%; Experimental group total effective rate is that 96%, two group of total effective rate relatively shows that experimental group curative effect is better than matched group.
Chinese medicine composition of the present invention is treated myocarditic medicine with other, and to compare effective percentage high, and total effective rate is 96%, higher by 56% than matched group effective percentage, successful is better than matched group, the Chinese medicine composition of this invention is cheap, and ordinary people life-time service can not increase health and pecuniary burden yet.In clinical experiment, there is not a routine side effect situation, safety is far above the myocarditic similar drugs for the treatment of, and evident in efficacy, cardiopalmus, the dizzy symptom of using Chinese medicine composition of the present invention can rapid recovery disease to bring, can also nurse one's health due to illness and debilitant health, the prescription that belongs to giving consideration to both the incidental and fundamental is the Chinese medicine composition for the treatment of at present the comparatively desirable safety of myocarditis.
Claims (3)
1. the myocarditic Chinese medicine composition for the treatment of, is characterized in that, takes off the medicine material of stating weight proportion and is prepared from: Semen Platycladi 3-9 part, Fructus Forsythiae 6-15 part, Radix Astragali 9-30 part, Medulla Junci 1-3 part, Flos Carthami 3-9 part, Ramulus Cinnamomi 3-9 part, Radix Ophiopogonis 6-12 part, Radix Curcumae 3-9 part, Radix Pseudostellariae 9-30 part, Fructus Trichosanthis 9-15 part, Herba Lophatheri 6-9 part, Rhizoma Arisaematis 3-9 part, Radix Glycyrrhizae Preparata 1.5-9 part, Cortex Albiziae 6-12 part, Fructus Schisandrae Chinensis 1.5-6 part, Radix Salviae Miltiorrhizae 9-15 part.
2. Chinese medicine composition according to claim 1, is characterized in that, takes off the medicine material of stating weight proportion and is prepared from: Semen Platycladi 5-8 part, Fructus Forsythiae 8-12 part, Radix Astragali 12-25 part, Medulla Junci 1.5-2.5 part, Flos Carthami 5-8 part, Ramulus Cinnamomi 4-7 part, Radix Ophiopogonis 7-10 part, Radix Curcumae 5-7 part, Radix Pseudostellariae 15-25 part, Fructus Trichosanthis 10-13 part, Herba Lophatheri 7-8 part, Rhizoma Arisaematis 5-8 part, Radix Glycyrrhizae Preparata 3-6 part, Cortex Albiziae 8-10 part, Fructus Schisandrae Chinensis 3-5 part, Radix Salviae Miltiorrhizae 10-13 part.
3. Chinese medicine composition according to claim 1, is characterized in that, takes off the medicine material of stating weight proportion and is prepared from: 6 parts of Semen Platycladi, 10 parts of Fructus Forsythiaes, 20 parts of the Radixs Astragali, 2 parts of Medulla Juncies, 6 parts, Flos Carthami, 5 parts of Ramulus Cinnamomi, 8 parts of Radix Ophiopogonis, 6 parts of Radix Curcumaes, 20 parts of Radix Pseudostellariaes, 12 parts of Fructus Trichosanthis, 8 parts of Herba Lophatheris, 6 parts of Rhizoma Arisaematiss, 4 parts of Radix Glycyrrhizae Preparatas, 9 parts of Cortex Albiziaes, 4 parts of Fructus Schisandrae Chinensis, 12 parts of Radix Salviae Miltiorrhizaes.
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