CN103736028A

CN103736028A - Traditional Chinese medicine composition for treating oral lichen planus

Info

Publication number: CN103736028A
Application number: CN201410022100.4A
Authority: CN
Inventors: 秦泽淼
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-01-11
Filing date: 2014-01-11
Publication date: 2014-04-23

Abstract

The invention relates to a drug for treating oral lichen planus, and particularly relates to a traditional Chinese medicine composition made of a plant Chinese herbal medicine as a raw material for treating oral lichen planus. The traditional Chinese medicine composition is characterized by comprising the following crude drugs by weight: 13-19g of honeysuckle, 13-19g of astragalus membranaceus, 10-15g of curcuma zedoary, 10-15g of ligusticum wallichii, 10-15g of coptidis rhizome, 10-15g of caulis sargentodoxae, 10-15g of pinellia ternate, 15-25g of codonopsis pilosula, 3-9g of typhae pollen, and 3-9g of radix glycyrrhizae. The traditional Chinese medicine composition has the beneficial effects that each component of the traditional Chinese medicine adopts a natural traditional Chinese medicine material, so that the traditional Chinese medicine composition is simple in configuration, wide in drug source, and low in cost, has a synergistic effect in drug effect, has the effects of invigorating the spleen and replenishing qi, clearing heat and eliminating dampness, clearing away heat and toxic materials, activating blood circulation and removing blood stasis, dispelling wind and relieving pain and the like, and is significant in effect on treatment of the oral lichen planus.

Description

A kind of Chinese medicine composition for the treatment of oral lichen planus

Technical field

The present invention relates to treat the medicine of oral lichen planus, especially a kind of Chinese medicine composition of the treatment oral lichen planus of making take vegetable Chinese herbal medicine as raw material.

Background technology

Oral lichen planus is a kind of common chronic oral mucosa dermatosis, does not generally have infectiousness.The principal character of oral lichen planus is pearly-lustre vitta stricture of vagina, and its lineae ablicantes can extend to all directions, or is woven into netted, dendroid, the different shapes such as ring-type, or be speckle shape, sometimes can there is the multiple disease damages such as pimple, vesicle, erosion, conscious coarse, the tractive of patient or pain.This sick pathogenesis is not yet completely clear and definite, current research shows, its morbidity is relevant with Nervous and Mental Factors (as fatigue, anxiety, anxiety), immune factor, endocrine factors, infective agent, microcirculation disturbance factor, trace element deficiency and some general disease (diabetes, infection, hypertension, digestive tract function disorder).Clinical research discovery, oral lichen planus has certain canceration.

The traditional Chinese medical science thinks that primary disease and " mouthful broken ", " erosion of the oral mucosa " are alike, also has and thinks similar with " mouthful gill fungus ", " mouthful moss ".Its morbidity and internal damage by the excessive seven emotions, affection due to external wind and heat pathogenic dryness is relevant.For example excessive thinking, impairing the spleen and stomach, dysfunction of the spleen in transportation, retention of water-damp in the body, accumulates and heat-transformation, heat is raw dry, domination of pathogenic dryness causing symptoms of dryness, can cause mucosa coarse, white stripes, oozes out erosion, affection due to external wind and heat enters inner fire-transformation, on steam in mouth, also can increase the weight of the state of an illness.Because of the spleen being the foundation of acquired constitution, main the whole body muscle, has one's ideas straightened out in mouth, liver controlling conveyance and dispersion, anger is impairing the liver, excessive rising of liver-YANG, consumption impairment of YIN blood, more increases endogenous dryness, thus the normal duty of primary disease in spleen, liver two warps.At present, domestic foreign minister, with adrenocortical hormone and retinoid Drug therapy oral lichen planus, is still not easy to cure, and relapse rate is high, and untoward reaction easily occurs, large to human body side effect.Therefore spy of the present invention has further preferably adopted a kind of Chinese medicine composition for the treatment of oral lichen planus.

Summary of the invention

The deficiency existing in order to overcome prior art treatment oral lichen planus, the invention provides a kind ofly prepare conveniently, medicine source is wide, cost is low, the Chinese medicine composition of the treatment oral lichen planus of evident in efficacy, reliable effect.

The technical solution adopted for the present invention to solve the technical problems is: a kind of Chinese medicine composition for the treatment of oral lichen planus, it is characterized in that: the crude drug of making effective ingredient by following weight is: Flos Lonicerae 13-19 gram, Radix Astragali 13-19 gram, Rhizoma Curcumae 10-15 gram, Rhizoma Chuanxiong 10-15 gram, Rhizoma Coptidis 10-15 gram, Caulis Sargentodoxae 10-15 gram, Rhizoma Pinelliae 10-15 gram, Radix Codonopsis 15-25 gram, Pollen Typhae 3-9 gram, Radix Glycyrrhizae 3-9 gram.

Usage: one day potion, be decocted in water for oral dose, patient can take for one day at twice, for the difficult patient that takes traditional Chinese medicine, can be on a small quantity sub-service repeatedly.It within 60 days, is a course for the treatment of.

The preferred technical solution of the present invention is: a kind of Chinese medicine composition for the treatment of oral lichen planus, it is characterized in that: the crude drug of making effective ingredient by following weight is: 16 grams of Flos Loniceraes, 16 grams of the Radixs Astragali, 13 grams of Rhizoma Curcumae, 13 grams of Rhizoma Chuanxiongs, 13 grams of Rhizoma Coptidis, 13 grams of Caulis Sargentodoxaes, 13 grams of the Rhizoma Pinelliaes, 20 grams of Radix Codonopsis, 6 grams of Pollen Typhaes, 6 grams, Radix Glycyrrhizae.

Pharmacological action

Flos Lonicerae: the effect with heat clearing away, removing toxic substances, removing heat from blood, dredge the meridian passage.Cure mainly anemopyretic cold, laryngopharynx swelling and pain, pneumonia, dysentery, carbuncle lump infections, erysipelas, cellulitis etc.

The Radix Astragali: energy invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema.

Rhizoma Curcumae: treating blood disorders blood circulation promoting and blood stasis dispelling, removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving, rushes down stomach.For qi depression to blood stasis, amenorrhea stomachache, lump in the abdomen; Eating and drinking without temperance, spleen fortune is not normal, food stagnation distending pain, distension and fullness in the abdomen pain; Early cervical carcinoma, ovarian cancer, disease sees in abdomen that enclosed mass is hard, pain, metrostaxis person, hepatocarcinoma, gastric cancer, cancer of pancreas, disease is seen abdominal distention dull pain in liver person.

Rhizoma Chuanxiong: blood circulation promoting and blood stasis dispelling, the effect of wind-expelling pain-stopping.Control menoxenia, amenorrhea, dysmenorrhea, wind syndrome of head headache, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, traumatic injury.

Pollen Typhae: there are the effects such as promoting blood circulation to remove blood stasis, pain relieving, also very effective to oral ulcer.

Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion acid regurgitation, toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.

Caulis Sargentodoxae: promoting blood circulation to remove obstruction in the collateral, the dissipating blood stasis that relieves internal heat, wind dispelling insecticide.For abdominalgia with intestinal abscess, traumatic injury, dysmenorrhea, Fengshi Guanjie pain.

The Rhizoma Pinelliae: drying dampness to eliminate phlegm; Stopping nausea and vomiting by lowering the adverse flow of QI; Dissolving lump and resolving mass.Cure mainly: cough with asthma abundant expectoration; Vomiting regurgitation; Feeling of oppression and fullness in the chest and epigastrium headache is dizzy; Uneasy sleeping at night; Gall subcutaneous nodule; Swollen ulcer drug.

Radix Codonopsis: tool invigorating the spleen and replenishing QI, the stomach function regulating effect such as nourish blood, should be used for fatigue and weakness usually, lassitude, conscious breathing hard, the slightly movable deficiency of vital energy patient with regard to dyspnea with rapid and short breath, because QI invigorating also contributes to hemopoietic, so Radix Codonopsis is also applicable to QI and blood deficiency pale complexion, feels dizzy, and has no appetite, rare soft, easy to catch cold patient defecates.

Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

The invention has the beneficial effects as follows, each component of Chinese medicine of the present invention all adopts natural raw material of Chinese medicine, and its configuration is simple, and medicine source is wide, cost is low.This herbal medicine efficacy synergism, has invigorating the spleen and replenishing QI, heat clearing and damp drying, and heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, the effects such as wind-expelling pain-stopping, have remarkable result to treatment oral lichen planus.

Below in conjunction with clinical experiment data declaration beneficial effect of the present invention:

Clinical data

Inventor collects outpatient service and inpatient's 112 examples of oral lichen planus in June, 2010 to 2011 altogether between year JIUYUE, male 43 examples, female's 69 examples, age 30-75 year.Be divided at random two groups, wherein treatment group 56 examples, male 19 examples, female's 37 examples; Age 30-75 year, the course of disease 8 months to 3 years, matched group 56 examples, male 24 examples, female's 32 examples, between age 30-73 year, the course of disease 6 months to 3 years; The data there was no significant differences (P>0.05) such as two groups of sexes, age, have comparability.

Therapeutic Method

Matched group adopts prednisone treatment, oral, each 15m g, and early morning, decoction being taken at a draught, treated drug withdrawal after 2 days, after 5 days, continued to take, and reduced gradually dose to 5m g every day, drug withdrawal, 1 is treated the course for the treatment of is 2 months.

Treatment group is taken the present invention and treats the Chinese medicine composition of oral lichen planus.Potion, divided and took for 2-3 time every day.It within 2 months, is a course for the treatment of.

Criterion of therapeutical effect

According to Chinese stomatology, understand the standard of diseases of oral mucosa Professional Committee formulation and carry out efficacy evaluation.Effective: congested, erosion disappears completely, and white stripes disappears or be not obvious, and pain disappears completely; Effective: hyperemia, white stripes, rotten to the corn area reduce, pain relief; Invalid: hyperemia, white stripes, rotten to the corn area is unchanged or increase, pain is without alleviating or increasing the weight of.

Therapeutic effect

Treatment statistical result is in Table 1

Table 1 liang group curative effect comparison

Group	Case load	Effective	Effectively	Invalid	Total effective rate (%)
						Treatment group	56	33	16	7	87.5
Matched group	56	24	15	17	69.6

Clinical observation shows, on therapeutic effect, treatment group has obvious advantage than matched group.

Model case:

Make pottery so-and-so, man, 46 years old, in JIUYUE, 2010, there is oral cavity pain, feed difficulty, is oral lichen planus to hospital diagnosis, through multi-medicament, fails to respond to any medical treatment, so take the present invention and treat the Chinese medicine composition of oral lichen planus, after 1 course for the treatment of, symptom alleviates to some extent, after 1 course for the treatment of that holds on, fully recovers, and follows up a case by regular visits to and within 1 year, has no outbreak.

King so-and-so, female, 55 years old, rotten to the corn 2 years of right buccal, after diagnosing, right buccal mucosa erosion, about 1.5cm*0.9cm size, around adularescent texture sample becomes, obscure boundary, be diagnosed as oral lichen planus, invalid through multi-treatment, so take the present invention and treat the Chinese medicine composition of oral lichen planus, after 1 course for the treatment of, symptom alleviates to some extent, hold on after 1 course for the treatment of and fully recover, follow up a case by regular visits to and within 1 year, have no outbreak.

The specific embodiment

A Chinese medicine composition for the treatment of oral lichen planus, is characterized in that: the crude drug of making effective ingredient by following weight is: 16 grams of Flos Loniceraes, 16 grams of the Radixs Astragali, 13 grams of Rhizoma Curcumae, 13 grams of Rhizoma Chuanxiongs, 13 grams of Rhizoma Coptidis, 13 grams of Caulis Sargentodoxaes, 13 grams of the Rhizoma Pinelliaes, 20 grams of Radix Codonopsis, 6 grams of Pollen Typhaes, 6 grams, Radix Glycyrrhizae.After first medicine being washed, with cold water soak 15-20 minute, then medicine is placed in the vessel of marmite, pottery or crock and so on (cannot use iron pan and aluminum pot), adds water to and do not have 5 centimetres of left and right of powder, decoct for the first time, after boiling with big fire, use instead little fire decoct 20-30 minute all right, medicine soup is poured in vessel, then decocts second time, the method that decocts second time is the same with first pass, just boils the little fire of rear use and decocts 15-20 minute.After having decocted, twice decoction extracting juice that removes slag, takes after merging.

Claims

1. treat the Chinese medicine composition of oral lichen planus for one kind, it is characterized in that: the crude drug of making effective ingredient by following weight is: Flos Lonicerae 13-19 gram, Radix Astragali 13-19 gram, Rhizoma Curcumae 10-15 gram, Rhizoma Chuanxiong 10-15 gram, Rhizoma Coptidis 10-15 gram, Caulis Sargentodoxae 10-15 gram, Rhizoma Pinelliae 10-15 gram, Radix Codonopsis 15-25 gram, Pollen Typhae 3-9 gram, Radix Glycyrrhizae 3-9 gram.

2. treat according to claim 1 the Chinese medicine composition of oral lichen planus, it is characterized in that: the crude drug of making effective ingredient by following weight is: 16 grams of Flos Loniceraes, 16 grams of the Radixs Astragali, 13 grams of Rhizoma Curcumae, 13 grams of Rhizoma Chuanxiongs, 13 grams of Rhizoma Coptidis, 13 grams of Caulis Sargentodoxaes, 13 grams of the Rhizoma Pinelliaes, 20 grams of Radix Codonopsis, 6 grams of Pollen Typhaes, 6 grams, Radix Glycyrrhizae.