CN105343750A - Traditional Chinese medicine composition for treating spleen-stomach deficiency type chronic gastritis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating spleen-stomach deficiency type chronic gastritis and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/906—Zingiberaceae (Ginger family)
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention belongs to the technical field of traditional Chinese medicine, and relates to a traditional Chinese medicine composition for treating spleen-stomach deficiency type chronic gastritis and a preparation method thereof. The traditional Chinese medicine composition is prepared from, by weight, 10-20 parts of suberect spatholobus stems, 10-22 parts of officinal magnolia bark, 12-20 parts of rhizoma atractylodis macrocephalae, 10-18 parts of fructus amomi, 8-18 parts of rhizoma atractylodis, 8-16 parts of poria cocos, 6-14 parts of herba dendrobii, 6-16 parts of milkvetch roots, 4-12 parts of gorgon euryale seeds, 6-10 parts of cortex cinnamomi, 4-12 parts of longan pulp and 2-10 parts of licorice roots. According to the traditional Chinese medicine composition, the formula ingredients are reasonable, primary and secondary are clearly demarcated, and mutual gain is achieved; all the medicines are coordinated in proper proportion, and the traditional Chinese medicine composition has the effects of invigorating the spleen, supplementing Qi, tonifying the stomach, promoting fluid, invigorating Qi for strengthening superficies and nourishing the blood for tranquillization and is suitable for patients who suffer from the spleen-stomach deficiency type chronic gastritis and worthy of wide promotion in clinic.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to and a kind ofly treat Chinese medicine composition of insufficiency of the spleen stomach weak type chronic gastritis and preparation method thereof.
Background technology
Chronic gastritis is the chronic inflammatory processes of gastric mucosa.Old people is due to gastric mucosa atrophy, and gastric acid secretion is very few, is called atrophic gastritis.This peculiar symptom, due to psychentonia, adds upper teeth bad, chews insufficient, easily suffers from chronic gastritis, is old common frdquently encountered disease.The traditional Chinese medical science belongs to " gastric abscess " category, thinks and to be caused by emotional stimulation, eating and drinking without temperance, incoordination between cold and warm etc.Lack specific symptom clinically, most of patients has no symptom, and only chanced on when gastroscopy, have epigastrium pain during morbidity, dyspepsia, majority feels glutted after meal, belch or acid regurgitation water.The chronic gastritis cause of disease is not yet fully aware of, may be relevant with Bad Eating Habit, some food long-time stimulus (wine, tea, coffee etc.), acute gastritis etc.Superficial gastritis can be divided into, atrophic gastritis and hypertrophic gastritis by pathology.The primary disease course of disease is long, Symptoms last, recurrent exerbation.Chronic atrophic gastritis has the people of 8-13% to change gastric cancer into.Therefore should suitably take good care of chronic gastritis patient.
Gastritis is divided into 4 classes by the traditional Chinese medical science usually, belongs to the disease category such as Chinese medicine " gastric abscess ", " feeling of fullness ", " acid regurgitation ", " noisy ", " indigestion and loss of appetite ", be respectively: hepatogastric vital energy stagnation type, deficiency of the spleen and heat of the stomach type, due to weakness of spleen and stomach, type of deficiency of stomach yin.The cause of disease of gastritis is more complicated, and how because long-term feelings will is unsuccessful, eating and drinking without temperance, work and rest is not normal, causes depression of liver-QI, dysfunction of the spleen in transportation, and gastral cavilty is become estranged, gas virtual loss with the passing of time, thus causes all symptoms.Determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs should be given clinically according to the practical situation of patient.
Chronic gastritis belongs to the spleen-stomach disease category, and spleen is the cloudy soil of dirty genus, and transporting is not good for, duty in spleen, treatment business at replenishing QI to invigorate the spleen activating the spleen, normal suitable the lucid yang sending up; Stomach is that internal organs belongs to sun soil, main by Na Shuigu, to lead to for use, reducing to and, once ill, namely there is feeling of distension and oppression, all cards of the turbid YIN failing to descendes such as nausea, control when sending down the abnormal ascending QI dissipating depression of QI purging FU-organs, so conditioning lifting is one of key for the treatment of the spleen and stomach illness.The traditional Chinese medical science thinks that The spleen and stomach provide the material basis of the acquired, can chronic disease to very bigger with the prosperity and decline relation of gastric qi, treatment for chronic gastritis must not be forgotten to safeguard gastric qi, medication gets that it is gentle, need not Wen great Re, the product in large bitter Great Cold greatly, meets Deficiency and coldness of spleen and stomach person based on replenishing QI to invigorate the spleen, make QI invigorating and do not stop up stagnant, do not hinder stomach, and the product of normal assistant acupuncture, to declare smooth mechanism of qi.
At present the patent of invention of disclosed treatment chronic gastritis has a lot, such as: 201310693697.0,201510051352.4,201410556293.1,201310457618.6 etc.But chronic gastritis disease type is various, the patent of invention of stomach weak type chronic gastritis that immunotherapy targeted autoantibody is insufficiency of the spleen is little, Chinese patent application 201410771775.9 discloses a kind of Chinese medicine for the treatment of insufficiency of the spleen stomach weak type chronic gastritis, makes primarily of the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Dioscoreae, Semen Coicis, Cortex Magnoliae Officinalis, Rhizoma Alpiniae Officinarum, Fructus Jujubae, Radix Angelicae Sinensis, Radix Ginseng and Radix Glycyrrhizae.Although this invention Chinese medicine has the effect of spleen reinforcing nourishing the stomach, mediation gastric qi, the gastritis disease of patient can be alleviated, containing rare medicinal herbss such as Radix Angelicae Sinensis, Radix Ginseng and Radix Codonopsis in this invention medicine, source is few, and cost is high, significantly limit the use of this invention medicine.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition for the treatment of insufficiency of the spleen stomach weak type chronic gastritis, by selecting suitable medical material and regulating compatibility, reaches with strong points, effective fast, short treating period, cure rate are high, toxic and side effects is little object.
For realizing object of the present invention, technical solution of the present invention is as follows:
Chinese medicine composition of the present invention is prepared from by following weight portion medical material:
Caulis Spatholobi 10-20 part, Cortex Magnoliae Officinalis 10-22 part, Rhizoma Atractylodis Macrocephalae 12-20 part, Fructus Amomi 10-18 part, Rhizoma Atractylodis 8-18 part, Poria 8-16 part, Herba Dendrobii 6-14 part, Radix Astragali 6-16 part, Semen Euryales 4-12 part, Cortex Cinnamomi 6-10 part, Arillus Longan 4-12 part and Radix Glycyrrhizae 2-10 part.
In the scope of this weight portion, the comparatively significant formula of preferred 3 curative effects:
Formula 1: Caulis Spatholobi 10 parts, Cortex Magnoliae Officinalis 10 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Fructus Amomi 10 parts, Rhizoma Atractylodis 8 parts, 8 parts, Poria, Herba Dendrobii 6 parts, the Radix Astragali 6 parts, Semen Euryales 4 parts, Cortex Cinnamomi 6 parts, Arillus Longan 4 parts and 2 parts, Radix Glycyrrhizae.
Formula 2: Caulis Spatholobi 20 parts, Cortex Magnoliae Officinalis 22 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Fructus Amomi 18 parts, Rhizoma Atractylodis 18 parts, 16 parts, Poria, Herba Dendrobii 14 parts, the Radix Astragali 16 parts, Semen Euryales 12 parts, Cortex Cinnamomi 10 parts, Arillus Longan 12 parts and 10 parts, Radix Glycyrrhizae.
Formula 3: Caulis Spatholobi 15 parts, Cortex Magnoliae Officinalis 16 parts, the Rhizoma Atractylodis Macrocephalae 16 parts, Fructus Amomi 14 parts, Rhizoma Atractylodis 12 parts, 12 parts, Poria, Herba Dendrobii 10 parts, the Radix Astragali 10 parts, Semen Euryales 8 parts, Cortex Cinnamomi 8 parts, Arillus Longan 8 parts and 6 parts, Radix Glycyrrhizae.
Correspondingly, the present invention also provides the preparation method of described Chinese medicine composition, comprises the following steps:
Step 1, take ingredients in proportion respectively, decontamination, clean, dry, after section, be ground into coarse powder, for subsequent use;
Step 2, getting Caulis Spatholobi coarse powder, to add medical material gross weight 8-10 times amount volume fraction be the ethanol of 60-80%, add the cellulase of medical material total amount 0.8-1.2% again, lixiviate 1-2 hour at 38-45 DEG C, then at 85-95 DEG C of reflux, extract, 3-5 hour, filter and retain Caulis Spatholobi filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained Caulis Spatholobi extract;
Step 3, by Fructus Amomi, Rhizoma Atractylodis, the Radix Astragali, Cortex Cinnamomi and the mixing of Arillus Longan coarse powder, merge Caulis Spatholobi filtering residue, add 4-5 times amount water boiling and extraction 3-4 time of medical material gross weight, each 4-5h, filter, merge extractive liquid, extracting solution obtains extractum thing A through concentrating under reduced pressure and microwave drying;
Step 4, Cortex Magnoliae Officinalis, the Rhizoma Atractylodis Macrocephalae, Poria, Herba Dendrobii, Semen Euryales and Radix Glycyrrhizae coarse powder to be mixed, the 3-6 times amount volumetric concentration adding coarse powder gross weight is the alcoholic solution of 70-80%, soak 12-24h, reflux, extract, 3-4 time again, each 3-5h, filters, merging filtrate, filtrate cold preservation after alkalization leaves standstill, and refilter, gained filtrate obtains extractum thing B through concentrating under reduced pressure and microwave drying;
Step 5, Caulis Spatholobi extract, extractum thing A and extractum B fully to be mixed, spraying dry, obtain Chinese medicine composition fine powder.
Further, utilize modern general Chinese medicine preparation technology, Chinese medicine composition of the present invention makes tablet, capsule, granule or powder.
Source, the nature and flavor of Chinese prescription of the present invention Chinese crude drug used, return through and effect:
Caulis Spatholobi: this product is the plant of pulse family Millettia, bitter in the mouth, sweet, warm in nature; Return liver, kidney channel; Enrich blood, invigorate blood circulation, dredging collateral; Relaxing muscles and tendons to promote blood circulation, nourishing blood for regulating menstruation.
Cortex Magnoliae Officinalis: this product is the dry dried bark of Magnoliacea plant Cortex Magnoliae Officinalis or magnolia officinalis rehd.et wils.var.biloba rehd.et wils., root bark and branch skin; Bitter in the mouth, pungent, warm in nature; Return spleen, stomach, lung, large intestine channel; Dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full.
The Rhizoma Atractylodis Macrocephalae: this product is the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae; Bitter in the mouth, sweet, warm in nature; Return spleen, stomach warp; Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.
Fructus Amomi: this product is the dry mature fruit of zingiberaceous plant Fructus Amomi; Acrid in the mouth, warm in nature; Return spleen, stomach, kidney channel; Removing dampness is whetted the appetite, warming spleen and stopping diarrha, regulates the flow of vital energy antiabortive.
Rhizoma Atractylodis: this product is the dry rhizome of feverfew Atractylodes lancea (Thunb.) DC.; Acrid in the mouth, hardship, warm in nature; Return spleen, stomach, Liver Channel; Drying damp and strengthening spleen, expelling wind and cold, improving eyesight.
Poria: this product is the dry sclerotia of On Polyporaceae Poria; Sweet in the mouth, light, property is put down; GUIXIN, lung, spleen, kidney channel; Promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, spleen invigorating mind calming.
Herba Dendrobii: this product is the fresh or dry stem of orchid dendrobium loddigesii Rolfe; Sweet in the mouth, cold nature; Return stomach, kidney channel; Reinforcing stomach reg fluid, nourishing YIN and clearing away heat.
The Radix Astragali: this product is the dry root of leguminous plant Radix Astagali or Radix Astragali; Sweet in the mouth, warm in nature; Return lung, spleen channel; Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.
Semen Euryales: this product is the dry mature kernal of nymphaeaceae plant Gorgon euryale; Sweet in the mouth, puckery, property is put down; Return spleen, kidney channel; Supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, damp eliminating leukorrhagia stopping.
Cortex Cinnamomi: this product is the dry bark of canella Cortex Cinnamomi; Acrid in the mouth, sweet, extremely hot in nature; Return kidney, spleen, the heart, Liver Channel; Mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.
Arillus Longan: this product is the aril of Sapindaceae Euphoria plant Arillus Longan; Sweet in the mouth, warm in nature; GUIXIN, spleen channel; Invigorating the heart and spleen, nourishing blood to tranquillize the mind.
Radix Glycyrrhizae: this product is glycyrrhizic legume dry root; Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The compatibility analysis of Chinese medicine composition of the present invention:
Chinese medicine composition of the present invention with Cortex Magnoliae Officinalis and the Rhizoma Atractylodis Macrocephalae for monarch drug, the therapeutic method to keep the adverse QI flowing downwards except full, invigorating the spleen and benefiting QI, dampness diuretic; With Caulis Spatholobi, Fructus Amomi, Rhizoma Atractylodis, Poria and Herba Dendrobii for ministerial drug, removing dampness is whetted the appetite, drying damp and strengthening spleen, promoting diuresis to eliminate damp pathogen, reinforcing stomach reg fluid; With the Radix Astragali, Semen Euryales, Cortex Cinnamomi and Arillus Longan for adjuvant drug, invigorating QI to consolidate the body surface resistance, supplementing the kidney to control the nocturnal, invigorating the heart and spleen, nourishing blood to tranquillize the mind; With Radix Glycyrrhizae for making medicine, invigorating the spleen and replenishing QI, relieving spasm to stop pain, the coordinating the actions of various ingredients in a prescription property of medicine.All medicines coordinate, and complement each other, synergism, plays invigorating the spleen and benefiting QI altogether, reinforcing stomach reg fluid, invigorating QI to consolidate the body surface resistance, the effects such as nourishing blood to tranquillize the mind, have very significant curative effect to the insufficiency of the spleen stomach weak type chronic gastritis for the treatment of.
Compared with prior art, Chinese medicine composition of the present invention has following advantage:
Compared with the chemotherapeutic agent of 1, stomach weak type chronic gastritis insufficiency of the spleen with Current therapeutic, Chinese medicine composition of the present invention is made up of pure natural Chinese herbal medicine, and reasonable, all medicine of compatibility is worked in coordination with, stress conditioning.
2, zoopery shows, Chinese medicine composition of the present invention significantly can increase the cAMP of insufficiency of the spleen stomach weak type chronic gastritis rat plasma and gastric mucosa, has good curative effect; Clinical experiment shows, compared with positive control drug hydrotalcite tablet, Chinese medicine composition of the present invention has rapid-action, that short treating period, cure rate are high and toxic and side effects is little advantage.
3, simple and easy to do, the efficacy stability of Chinese medicine composition preparation technology of the present invention, be applicable to be made into various dosage form, be beneficial to and promote the use of.
Detailed description of the invention
Below will the present invention is described further by specific embodiment, but the present invention is not limited only to following examples.It will be understood by those skilled in the art that for, the present invention is except following examples, the change carried out the present invention under the condition not departing from content of the present invention, spirit and scope, combination or replacement, be apparent for a person skilled in the art, be all included within the scope of the present invention.
embodiment 1
The embodiment of the present invention 1 Chinese medicine composition is prepared from by following weight portion medical material:
Caulis Spatholobi 10 parts, Cortex Magnoliae Officinalis 10 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Fructus Amomi 10 parts, Rhizoma Atractylodis 8 parts, 8 parts, Poria, Herba Dendrobii 6 parts, the Radix Astragali 6 parts, Semen Euryales 4 parts, Cortex Cinnamomi 6 parts, Arillus Longan 4 parts and 2 parts, Radix Glycyrrhizae.
Preparation method is as follows:
Step 1, take ingredients in proportion respectively, decontamination, clean, dry, after section, be ground into coarse powder, for subsequent use;
Step 2, getting Caulis Spatholobi coarse powder, to add medical material gross weight 10 times amount volume fraction be the ethanol of 80%, add the cellulase of medical material total amount 1.2% again, lixiviate 2 hours at 45 DEG C, then 95 DEG C of reflux, extract, 5 hours, filter and retain Caulis Spatholobi filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10, obtained Caulis Spatholobi extract;
Step 3, by Fructus Amomi, Rhizoma Atractylodis, the Radix Astragali, Cortex Cinnamomi and the mixing of Arillus Longan coarse powder, merge Caulis Spatholobi filtering residue, add the 5 times amount water boiling and extraction 4 times of medical material gross weight, each 5h, filter, merge extractive liquid, extracting solution obtains extractum thing A through concentrating under reduced pressure and microwave drying;
Step 4, Cortex Magnoliae Officinalis, the Rhizoma Atractylodis Macrocephalae, Poria, Herba Dendrobii, Semen Euryales and Radix Glycyrrhizae coarse powder to be mixed, the 6 times amount volumetric concentrations adding coarse powder gross weight are the alcoholic solution of 80%, soak 24h, reflux, extract, 4 times again, each 5h, filters, merging filtrate, filtrate cold preservation after alkalization leaves standstill, and refilter, gained filtrate obtains extractum thing B through concentrating under reduced pressure and microwave drying;
Step 5, Caulis Spatholobi extract, extractum thing A and extractum B are fully mixed, spraying dry, obtains traditional Chinese medicine fine powder;
The traditional Chinese medicine fine powder of step 6, past step 5 gained adds suitable adjuvant, utilizes modern general preparation technique to be prepared into capsule.
embodiment 2
The embodiment of the present invention 2 Chinese medicine composition is prepared from by following weight portion medical material:
Caulis Spatholobi 20 parts, Cortex Magnoliae Officinalis 22 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Fructus Amomi 18 parts, Rhizoma Atractylodis 18 parts, 16 parts, Poria, Herba Dendrobii 14 parts, the Radix Astragali 16 parts, Semen Euryales 12 parts, Cortex Cinnamomi 10 parts, Arillus Longan 12 parts and 10 parts, Radix Glycyrrhizae.
Preparation method, with embodiment 1.
embodiment 3
The embodiment of the present invention 3 Chinese medicine composition is prepared from by following weight portion medical material:
Caulis Spatholobi 15 parts, Cortex Magnoliae Officinalis 16 parts, the Rhizoma Atractylodis Macrocephalae 16 parts, Fructus Amomi 14 parts, Rhizoma Atractylodis 12 parts, 12 parts, Poria, Herba Dendrobii 10 parts, the Radix Astragali 10 parts, Semen Euryales 8 parts, Cortex Cinnamomi 8 parts, Arillus Longan 8 parts and 6 parts, Radix Glycyrrhizae.
Preparation method, with embodiment 1.
pharmacodynamic study
chinese medicine composition of the present invention is on the impact of the insufficiency of the spleen stomach weak type chronic gastritis animal model of multifactor simulation
1, experimental technique
Principle: from theory of Chinese medical science and clinical, builds insufficiency of the spleen stomach weak type chronic gastritis disease animal model with induce by multifactor SD rats such as the addiction for one of five flavors of long period and hungry full overstrains, and carries out cyclic nucleotide (cAMP) assay to this model.
Method: the male SD healthy rat of SPF level 72 is selected in this experiment.Choose 12 rats as Normal group, all the other 60 rats are for building the animal model of insufficiency of the spleen stomach weak type chronic gastritis.During modeling, first with 2% sodium salicylate gavage, 2ml/ pcs/day, successive administration surrounding.5th week starts, while gavage sodium salicylate, then applies the modeling condition of the weak disease of insufficiency of the spleen stomach, the rat odd-numbered day is run on electric roller type treadmill, and fasting, even-numbered days are at warm water went swimming, and ad lib is quantity-unlimiting, continues surrounding, make the excessive overstrain of animal and irregular diet.
2, animal grouping and administration
After determining modeling success, 60 rat models are divided into 5 groups at random, 12/group, are respectively: model group, positive drug control group, the obtained capsule of the embodiment of the present invention 1 is high, in and low dose group.Wherein, positive drug control group rat oral gavage administration hydrotalcite tablet (Sichuan Jewelland Pharmaceutical Co., Ltd.), a 8g/Kg, 3 times on the one, takes for after feeding 15-30 minute.High, in and the capsule of the low dose group gastric infusion embodiment of the present invention 1 preparation, dosage is respectively: 8g/Kg, 4g/Kg and 2g/Kg.Normal group and model group gavage normal saline.Successive administration 21 days, observes the sign performance of 6 groups of rats during medication, and gets blood respectively to all animals and get gastric mucosa utilization radioimmunology after putting to death, and measures the blood plasma of each group and the cAMP content of gastric mucosa, the results are shown in Table 1 and table 2.
3, experimental result
Table 1 Chinese medicine composition of the present invention affects gastritis rat model sign
Table 2 Chinese medicine composition of the present invention is to the therapeutical effect of gastritis rat model disease
Note: compare with normal group,
△ △ △ p< 0.001; Compare with model group,
* p< 0.05,
* p< 0.01,
* * p< 0.001; Compare with positive controls,
# p< 0.05.
From upper table 1 and table 2, compare with normal group, the blood plasma of model group rats and the cAMP of gastric mucosa extremely significantly reduce (
p< 0.001), modeling success is described; Compare with model group, after the high, medium and low dosage of rat oral gavage administration Chinese medicine composition of the present invention and positive control drug, the cAMP of blood plasma and gastric mucosa all significantly increases (
p< 0.05), wherein Chinese medicine composition of the present invention presents good dose relationship; Compare with positive controls, the cAMP of Chinese medicine composition high dose group blood plasma of the present invention and gastric mucosa increase have significant difference (
p< 0.05), show that the curative effect of traditional Chinese medicine composition for treating of the present invention insufficiency of the spleen stomach weak type chronic gastritis rat is better, and the present invention is high, in and low dose group disease be improved significantly, hair color gloss, smooth gradually, spirit is recovered gradually, and ear color is ruddy, and appetite increases.Illustrate that the present invention has the advantage of its uniqueness in the disease treatment for insufficiency of the spleen stomach weak type chronic gastritis.
chinese medicine composition of the present invention is to the clinical observation on the therapeutic effect of insufficiency of the spleen stomach weak type chronic gastritis clinical volunteers patient
1, physical data
1.1 patient's physical data
Choose 480 routine insufficiency of the spleen stomach weak type Patients with Chronic Gastritis clinical volunteers, in age 18-60 year, the mean age is 37 years old; The course of disease 8 months-18 years, average course of disease is 7 years.Be divided into treatment A, B, C group and matched group four groups at random, often organize each 120 people, four groups at age, sex, coincident with severity degree of condition without too big-difference, there is comparability.
1.2 diagnostic criteria
1.2.1 Western medicine diagnose standard
Symptom: often have eating and drinking without temperance or the medical history such as feelings will is not smooth.Symptom is without specificity, and about half has epigastric discomfort, and dull pain, burning pain, pantothenic acid, glutted, nauseating, the indigestion symptom such as belch, loss of appetite, have rotten to the corn person can have a small amount of or a large amount of upper gastrointestinal hemorrhage.
Auxiliary examination: (1) gastroscopy: mucosa injury, visible erythema (point, lamellar, strip), coarse injustice, petechia/speckle, color and luster is gloomy.As there is the rotten to the corn or bile reflux of smooth erosion, protuberance simultaneously, be then diagnosed as superficial gastritis or atrophic gastritis accompanied is rotten to the corn or bile reflux.(2) gastric analysis, PH is most of on the low side.(3) diagnosis of H.P Gastritis: histology, urease, antibacterial culturing, 13C or the 14C urea breath experiment any one positive.(4) coherence check of autoimmune gastritis: should survey PCA and IFA suspected of autoimmune gastritis person, as mostly being positive for this sick PCA, during companion's pernicious anemia, IFA is positive more.
1.2.2 tcm diagnosis standard
With reference to " combination of Chinese and Western medicine diagnosis and treatment project (draft) of insufficiency of the spleen stomach weak type chronic gastritis ", insufficiency of the spleen stomach weak type chronic gastritis has following disease feature:
Main symptom: 1. vague epigastralgia.2. pain relieved by pressing happiness is warm.3. after food, gastral cavity is vexed.4. appetite stimulator.5. loose stool diarrhoea.6. limbs fatigue.7. body of the tongue is light red, has tooth to print, white and thin fur or white.
Secondary card: the 1. visible erythema of gastric mucosa or coarse injustice.2. mucus is thin and many.3. gastric acid is on the low side.4. deep-thready pulse.
Dialectical requirement: possess main symptom 3 and add time card 1, or main symptom 2 adds time card 2.
1.3 inclusive criteria
(1) insufficiency of the spleen stomach weak type chronic gastritis Western medicine diagnose standard or TCM syndrome diagnostic criteria is met; (2) age >=18 years old; (3) the Hospital Ethical Committee examination & verification person of passing through; (4) patient's informed consent, and signature Informed Consent Form person.
1.4 exclusion standard
(1) patient of general or other system disease is had; (2) gestation and women breast-feeding their children; (3) the medicine patient affecting taste and sensory function was taken in nearly 3 months; (4) ethanol, drug dependence patient, and to trial drug allergy sufferers.
2, Therapeutic Method
Treatment A, B, C group: take Chinese medicinal composition capsules prepared by the embodiment of the present invention 1,2,3 respectively, every day 3 times, one time 1 (containing crude drug amount 350mg/ sheet), 1-2 hour after the meal oral, 7 days courses for the treatment of, totally 4 courses for the treatment of.
Matched group: take hydrotalcite tablet (Sichuan Jewelland Pharmaceutical Co., Ltd.), every day 3 times, one time 1.1-2 hour after the meal, sleep before or stomach discomfort time take, 7 days courses for the treatment of, totally 4 courses for the treatment of.
3, therapeutic outcome
According to clinical observation, four groups of patient's capsules that the oral embodiment of the present invention is made respectively and hydrotalcite tablet, the Clinical efficacy comparison after 2 courses for the treatment of and 4 course of therapy is in table 3 and table 4:
Clinical efficacy comparison after table 3 each group patient 2 course of therapy
Clinical efficacy comparison after table 4 each group patient 4 course of therapy
From upper table 3, the capsule that the oral embodiment of the present invention of patient is obtained, after 2 course of therapy, cure rate reaches more than 45%, and total effective rate reaches more than 87%, and therapeutic effect is better than oral positive control drug hydrotalcite tablet, Chinese medicine composition good effect of the present invention is described, instant effect, the treatment time that obviously can shorten insufficiency of the spleen stomach weak type chronic gastritis is long, alleviate in time patient misery.But, through the treatment of 2 courses for the treatment of, the cure rate that respectively group is overall is lower, therefore the extended treatment time, medication treatment is continued to the clinical volunteers reaching curative effect not yet, as can be seen from Table 4, extend administration time, the cure rate of two groups all increases, wherein take embodiment of the present invention capsule cure rate and reach more than 70%, total effective rate reaches more than 90%, is obviously better than cure rate and the total effective rate of taking positive drug, and better with the effect for the treatment of A group and embodiment 1.
In addition, by the diagnostic observation during 480 routine clinical volunteers's medications and tracking access, find that the untoward reaction such as constipation in various degree, loose stool, xerostomia and anorexia have appearred in the patient of 20-40% during oral positive control drug; And 360 of oral Chinese medicine composition of the present invention routine patient's physical and mental statuses are good, all do not occur untoward reaction, drug safety of the present invention is described, toxic and side effects is little, has good clinical generalization value.
Claims (7)
1. treat a Chinese medicine composition for insufficiency of the spleen stomach weak type chronic gastritis, it is characterized in that, described Chinese medicine composition is prepared from by following weight portion medical material:
Caulis Spatholobi 10-20 part, Cortex Magnoliae Officinalis 10-22 part, Rhizoma Atractylodis Macrocephalae 12-20 part, Fructus Amomi 10-18 part, Rhizoma Atractylodis 8-18 part, Poria 8-16 part, Herba Dendrobii 6-14 part, Radix Astragali 6-16 part, Semen Euryales 4-12 part, Cortex Cinnamomi 6-10 part, Arillus Longan 4-12 part and Radix Glycyrrhizae 2-10 part.
2. the Chinese medicine composition for the treatment of according to claim 1 insufficiency of the spleen stomach weak type chronic gastritis, is characterized in that, described Chinese medicine composition is prepared from by following weight portion medical material:
Caulis Spatholobi 10 parts, Cortex Magnoliae Officinalis 10 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Fructus Amomi 10 parts, Rhizoma Atractylodis 8 parts, 8 parts, Poria, Herba Dendrobii 6 parts, the Radix Astragali 6 parts, Semen Euryales 4 parts, Cortex Cinnamomi 6 parts, Arillus Longan 4 parts and 2 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition for the treatment of according to claim 1 insufficiency of the spleen stomach weak type chronic gastritis, is characterized in that, described Chinese medicine composition is prepared from by following weight portion medical material:
Caulis Spatholobi 20 parts, Cortex Magnoliae Officinalis 22 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Fructus Amomi 18 parts, Rhizoma Atractylodis 18 parts, 16 parts, Poria, Herba Dendrobii 14 parts, the Radix Astragali 16 parts, Semen Euryales 12 parts, Cortex Cinnamomi 10 parts, Arillus Longan 12 parts and 10 parts, Radix Glycyrrhizae.
4. the Chinese medicine composition for the treatment of according to claim 1 insufficiency of the spleen stomach weak type chronic gastritis, is characterized in that, described Chinese medicine composition is prepared from by following weight portion medical material:
Caulis Spatholobi 15 parts, Cortex Magnoliae Officinalis 16 parts, the Rhizoma Atractylodis Macrocephalae 16 parts, Fructus Amomi 14 parts, Rhizoma Atractylodis 12 parts, 12 parts, Poria, Herba Dendrobii 10 parts, the Radix Astragali 10 parts, Semen Euryales 8 parts, Cortex Cinnamomi 8 parts, Arillus Longan 8 parts and 6 parts, Radix Glycyrrhizae.
5., according to the Chinese medicine composition of the arbitrary described treatment insufficiency of the spleen stomach weak type chronic gastritis of claim 1-4, it is characterized in that, the preparation method of described Chinese medicine composition comprises the following steps:
Step 1, take ingredients in proportion respectively, decontamination, clean, dry, after section, be ground into coarse powder, for subsequent use;
Step 2, getting Caulis Spatholobi coarse powder, to add medical material gross weight 8-10 times amount volume fraction be the ethanol of 60-80%, add the cellulase of medical material total amount 0.8-1.2% again, lixiviate 1-2 hour at 38-45 DEG C, then at 85-95 DEG C of reflux, extract, 3-5 hour, filter and retain Caulis Spatholobi filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained Caulis Spatholobi extract;
Step 3, by Fructus Amomi, Rhizoma Atractylodis, the Radix Astragali, Cortex Cinnamomi and the mixing of Arillus Longan coarse powder, merge Caulis Spatholobi filtering residue, add 4-5 times amount water boiling and extraction 3-4 time of medical material gross weight, each 4-5h, filter, merge extractive liquid, extracting solution obtains extractum thing A through concentrating under reduced pressure and microwave drying;
Step 4, Cortex Magnoliae Officinalis, the Rhizoma Atractylodis Macrocephalae, Poria, Herba Dendrobii, Semen Euryales and Radix Glycyrrhizae coarse powder to be mixed, the 3-6 times amount volumetric concentration adding coarse powder gross weight is the alcoholic solution of 70-80%, soak 12-24h, reflux, extract, 3-4 time again, each 3-5h, filters, merging filtrate, filtrate cold preservation after alkalization leaves standstill, and refilter, gained filtrate obtains extractum thing B through concentrating under reduced pressure and microwave drying;
Step 5, Caulis Spatholobi extract, extractum thing A and extractum B fully to be mixed, spraying dry, obtain Chinese medicine composition fine powder.
6., according to the Chinese medicine composition of the arbitrary described treatment insufficiency of the spleen stomach weak type chronic gastritis of claim 1-4, it is characterized in that, described Chinese medicine composition makes tablet, capsule, granule or powder.
7., according to the preparation method of the Chinese medicine composition of the arbitrary described treatment insufficiency of the spleen stomach weak type chronic gastritis of claim 1-4, it is characterized in that, comprise the following steps:
Step 1, take ingredients in proportion respectively, decontamination, clean, dry, after section, be ground into coarse powder, for subsequent use;
Step 2, getting Caulis Spatholobi coarse powder, to add medical material gross weight 8-10 times amount volume fraction be the ethanol of 60-80%, add the cellulase of medical material total amount 0.8-1.2% again, lixiviate 1-2 hour at 38-45 DEG C, then at 85-95 DEG C of reflux, extract, 3-5 hour, filter and retain Caulis Spatholobi filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.25, obtained Caulis Spatholobi extract;
Step 3, by Fructus Amomi, Rhizoma Atractylodis, the Radix Astragali, Cortex Cinnamomi and the mixing of Arillus Longan coarse powder, merge Caulis Spatholobi filtering residue, add 4-5 times amount water boiling and extraction 3-4 time of medical material gross weight, each 4-5h, filter, merge extractive liquid, extracting solution obtains extractum thing A through concentrating under reduced pressure and microwave drying;
Step 4, Cortex Magnoliae Officinalis, the Rhizoma Atractylodis Macrocephalae, Poria, Herba Dendrobii, Semen Euryales and Radix Glycyrrhizae coarse powder to be mixed, the 3-6 times amount volumetric concentration adding coarse powder gross weight is the alcoholic solution of 70-80%, soak 12-24h, reflux, extract, 3-4 time again, each 3-5h, filters, merging filtrate, filtrate cold preservation after alkalization leaves standstill, and refilter, gained filtrate obtains extractum thing B through concentrating under reduced pressure and microwave drying;
Step 5, Caulis Spatholobi extract, extractum thing A and extractum B fully to be mixed, spraying dry, obtain Chinese medicine composition fine powder.
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| CN111701007A (en) * | 2020-08-12 | 2020-09-25 | 杭州博济堂健康咨询管理有限公司 | Traditional Chinese medicine composition for improving spleen and stomach functions and traditional Chinese medicine preparation |
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