CN105796845A - Application of medicine composition in preparing medicine for treating female climacteric syndromes - Google Patents
Application of medicine composition in preparing medicine for treating female climacteric syndromes Download PDFInfo
- Publication number
- CN105796845A CN105796845A CN201610191099.7A CN201610191099A CN105796845A CN 105796845 A CN105796845 A CN 105796845A CN 201610191099 A CN201610191099 A CN 201610191099A CN 105796845 A CN105796845 A CN 105796845A
- Authority
- CN
- China
- Prior art keywords
- parts
- pharmaceutical composition
- radix
- fructus
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention belongs to the technical field of traditional Chinese medicine, and relates to application of a medicine composition in preparing a medicine for treating female climacteric syndromes.The medicine composition is prepared from folium artemisiae argyi, herba leonuri, angelica sinensis, prepared rehmannia roots, common yam roots, Chinese dates, rhizoma anemarrhenae, pericarpium citri reticulatae viride, the fruits of Chinese wolfberry, the fruit of Chinese magnoliavine, ginseng and licorice roots.The medicine composition has the effects of enriching qi and activating blood, regulating menstruation and stopping pain, nourishing yin and moistening lung, removing cardiopyrexia for tranquilization, tonifying spleen and kidney and improving physical fitness, and has the advantages of being good in treatment effect, producing few side effects, being convenient to take and the like when used for treating female climacteric syndromes.
Description
The application be indigo plant ocean, applicant Yantai City herbalist's medicine bio tech ltd propose application for a patent for invention (denomination of invention is: a kind of pharmaceutical composition treating female climacteric syndrome and preparation method thereof, application number is: 201610147287X, and the applying date is: on March 16th, 2016) divisional application.
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of pharmaceutical composition purposes in preparation treatment female climacteric syndrome medicine.
Background technology
Female climacteric syndrome is that women ovarian function failed gradually to the transition period being wholly absent, and due to a series of clinical symptoms that physiology and psychology change and occurs, common warms sweating, irritable, palpitation and insomnia or melancholy forgetful etc..According to clinical manifestation, primary disease belongs to the category of " menopausal syndrome " of Chinese medicine.Primary disease is that women is before and after menopause, kidney qi is exhaustion gradually, virtual loss is appointed in punching, asthenia of essence and blood, menses is gradually exhausted, and menstruation will disconnected and physiological change that the menopause that arrives occurs, but some women is due to the impact of body constitution or Nervous and Mental Factors and other factors, for the moment do not adapt to these physiological changies, make negative and positive disequilibrium, internal organs QI and blood functional disorder and the disorderly syndrome of a series of functions of occurring.
Symptoms:
1, menoxenia: be climacteric women the most generally, the most prominent performance.Menstruation often postpones, and even some months is just risen once, also gradually decreases through amount.When estrogen is fewer and feweri, when endometrium can not have been caused to change, menstruation just stopped, and is called menopause.
2, battle array hot flush: be one of climacteric principal character, some women is owing to the level of estrogen declines within climacteric, and in blood, calcium level also declines to some extent, has a burst of position and generates heat, blushes, perspires, with dizzy, nervous, the persistent period be one or two minute or 12 minutes 15 minutes not etc..
3, cardiovascular and lipoidosis: it is possible that coronary heart disease, diabetes.
4, neural, mental disorder: the women having, blood pressure fluctuates more apparent up and down, it is possible to instability of being in a bad mood, emotional, personality change, hypomnesis, whole body discomfort etc..
5, motor system is degenerated: waist, back of the body limbs pain occur, scapulohumeral periarthritis, cervical spondylosis occurs in some women.
Chinese patent application CN201410621748 discloses a kind of Chinese medicine composition treating climacteric syndrome, this Chinese medicine composition is prepared from by the raw material of following weight portion: Radix Salviae Miltiorrhizae 10-15, Radix Codonopsis 10-15, Radix Asparagi 5-10, Fructus Ligustri Lucidi 15-20, Herba Ecliptae 10-15, Bulbus Lilii 15-20, Rhizoma Coptidis 5-10, Fructus Tritici Levis 10-15, Semen Ziziphi Spinosae 10-15, Radix Curcumae 15-20, Os Draconis 15-20, Fructus Schisandrae Chinensis 10-15, Poria 10-15, Radix Paeoniae Alba 5-10, Radix Angelicae Sinensis 10-15 and Rhizoma Sparganii 10-15, this Chinese medicine composition has and nourishes heart, calm the nerves, suppressing the hyperactive liver, clear away heart-fire, the kidney invigorating, nourishing kidney, qi-supplementing, blood-engendering, easing the affected liver, the effect invigorated blood circulation, but this pharmaceutical compositions is complicated, medicine cost is of a relatively high.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of pharmaceutical composition purposes in the medicine of preparation treatment female climacteric syndrome, this pharmaceutical composition has inrigorating qi and promoting blood circulation, menstruction regulating and pain relieving, nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization, tonifying speen and tonifying kidney and improve effect of body constitution, also having good effect, side effect is low and the advantage such as taking convenience.
What pharmaceutical composition of the present invention included following parts by weight prepares raw material: Folium Artemisiae Argyi 5-25 part, Herba Leonuri 9-25 part, Radix Angelicae Sinensis 3-25 part, Radix Rehmanniae Preparata 9-15 part, Rhizoma Dioscoreae 9-15 part, Fructus Jujubae 6-15 part, Rhizoma Anemarrhenae 6-12 part, Pericarpium Citri Reticulatae Viride 3-9 part, Fructus Lycii 3-9 part, Fructus Schisandrae Chinensis 3-6 part, Radix Ginseng 3-6 part and Radix Glycyrrhizae 1-12 part.
Further, what described pharmaceutical composition included following parts by weight prepares raw material: Folium Artemisiae Argyi 5 parts, Herba Leonuri 9 parts, Radix Angelicae Sinensis 3 parts, Radix Rehmanniae Preparata 9 parts, Rhizoma Dioscoreae 9 parts, 6 parts of Fructus Jujubae, the Rhizoma Anemarrhenae 6 parts, 3 parts of Pericarpium Citri Reticulatae Viride, Fructus Lycii 3 parts, Fructus Schisandrae Chinensis 3 parts, Radix Ginseng 3 parts and 1 part of Radix Glycyrrhizae.
Further, what described pharmaceutical composition included following parts by weight prepares raw material: Folium Artemisiae Argyi 25 parts, Herba Leonuri 25 parts, Radix Angelicae Sinensis 25 parts, Radix Rehmanniae Preparata 15 parts, Rhizoma Dioscoreae 15 parts, 15 parts of Fructus Jujubae, the Rhizoma Anemarrhenae 12 parts, 9 parts of Pericarpium Citri Reticulatae Viride, Fructus Lycii 9 parts, Fructus Schisandrae Chinensis 6 parts, Radix Ginseng 6 parts and 12 parts of Radix Glycyrrhizae.
Further, what described pharmaceutical composition included following parts by weight prepares raw material: Folium Artemisiae Argyi 15 parts, Herba Leonuri 16 parts, Radix Angelicae Sinensis 14 parts, Radix Rehmanniae Preparata 12 parts, Rhizoma Dioscoreae 12 parts, 12 parts of Fructus Jujubae, the Rhizoma Anemarrhenae 9 parts, 6 parts of Pericarpium Citri Reticulatae Viride, Fructus Lycii 6 parts, Fructus Schisandrae Chinensis 5 parts, Radix Ginseng 5 parts and 6 parts of Radix Glycyrrhizae.
Further, what described pharmaceutical composition included following parts by weight prepares raw material: Folium Artemisiae Argyi 20 parts, Herba Leonuri 21 parts, Radix Angelicae Sinensis 19 parts, Radix Rehmanniae Preparata 13 parts, Rhizoma Dioscoreae 14 parts, 13 parts of Fructus Jujubae, the Rhizoma Anemarrhenae 10 parts, 7 parts of Pericarpium Citri Reticulatae Viride, Fructus Lycii 8 parts, Fructus Schisandrae Chinensis 5 parts, Radix Ginseng 5 parts and 9 parts of Radix Glycyrrhizae.
Further, described pharmaceutical composition is capsule, tablet, powder, granule, oral liquid or pill.
The method of a kind of pharmaceutical composition preparing treatment female climacteric syndrome of disclosure, comprises the steps:
S1: weigh Folium Artemisiae Argyi, Herba Leonuri, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Jujubae, the Rhizoma Anemarrhenae, Pericarpium Citri Reticulatae Viride, Fructus Lycii, Fructus Schisandrae Chinensis, Radix Ginseng and Radix Glycyrrhizae, pulverize respectively, standby；
S2: all medical materials add the purified water of initial 8-12 times of weight of medical material, soaks 12-24 hour, decoct 1-3 hour, filters；Add the purified water of gross weight 5-9 times of weight of medical material, decoct 1-3 hour, filter and retain filtering residue, merging filtrate, be concentrated into the concentrated solution that 55 DEG C of-60 DEG C of relative densities are 1.20-1.25 standby；
S3: the filtering residue of S2 is added the ethanol of the concentration 65-80% of gross weight 5-7 times of weight of medical material, reflux, extract, 2-3 time, each 2-5 hour, to filter, merging filtrate, decompression is distilled off ethanol, and it is standby to be concentrated into the concentrated solution that 55 DEG C of-60 DEG C of relative densities are 1.20-1.25；
S4: merged by the concentrated solution of S2, S3 gained, continuing to be concentrated into 55 DEG C of-60 DEG C of relative densities is the Chinese medical concrete of 1.33-1.38, obtains pharmaceutical composition of the present invention.
The source of component used by the present invention, nature and flavor, return through and effect:
Folium Artemisiae Argyi: for the dried leaves of feverfew Chinese mugwort；Its acrid in the mouth, hardship, warm in nature；Return liver,spleen,kidney warp；Warming the meridian for stopping bleeding, dispersing cold for relieving pain, regulating menstruation is antiabortive, removing damp to relieve itching, dredge the meridian passage.
Herba Leonuri: this product is the fresh of labiate Herba Leonuri or dry aerial parts；Its bitter in the mouth, pungent, cold nature；Return liver, pericardium channel；Promoting blood flow to regulate menstruation, inducing diuresis to remove edema.
Radix Angelicae Sinensis: for the dry root of umbelliferae angelica；Its sweet in the mouth, pungent, warm in nature；Return liver, the heart, spleen channel；Inrigorating qi and promoting blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Radix Rehmanniae Preparata: for the Preparation process product of Radix Rehmanniae；Its sweet in the mouth, slightly warm in nature；Return liver, kidney channel；Nourishing YIN and supplementing blood, benefit essence fills out marrow.
Rhizoma Dioscoreae: for the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae；Its sweet in the mouth, property is put down；Return spleen, lung, kidney channel；Spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.
Fructus Jujubae: for the dry mature fruit of Rhamnaceae jujube Fructus Jujubae；Its sweet in the mouth, warm in nature；Return spleen, stomach warp；Invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.
The Rhizoma Anemarrhenae: for the dry rhizome of the liliaceous plant Rhizoma Anemarrhenae；Its bitter in the mouth, sweet, cold in nature；Return lung, stomach, kidney channel；Clearing away heat-fire, promotes the production of body fluid and moisturizes.
Pericarpium Citri Reticulatae Viride: for the peel of the dry young fruit of rutaceae orange and variety thereof or immature fruit；Its bitter in the mouth, pungent, warm in nature；Return liver, gallbladder, stomach warp；Soothing the liver dispelling the stagnated QI, removing food stagnancyization is stagnant.
Fructus Lycii: for the dry mature fruit of plant of Solanaceae lycium barbarum；Its sweet in the mouth, property is put down；Return liver, kidney channel；Nourishing kidney, lung moistening, tonifying liver, improving eyesight.
Fructus Schisandrae Chinensis: for the dry mature fruit of magnoliaceae schisandra or schisandra chinensis；Its sour in the mouth, sweet, warm in nature；Return lung, the heart, kidney channel；Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.
Radix Ginseng: for the dry root of Araliaceae Radix Ginseng；Its sweet in the mouth, micro-hardship, property is put down；Return spleen, lung, heart channel；Strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, calms the nerves.
Radix Glycyrrhizae: for the dry root of glycyrrhizic legume Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L.；Its sweet in the mouth, property is put down；GUIXIN, lung, spleen, stomach warp；Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The prescription analysis of Chinese prescription of the present invention:
Monarch drug in side of the present invention is Folium Artemisiae Argyi and Herba Leonuri, dispersing cold for relieving pain, removing damp to relieve itching, dredge the meridian passage, promoting blood flow to regulate menstruation；Ministerial drug is Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Rhizoma Dioscoreae and Fructus Jujubae, menstruction regulating and pain relieving, nourishing YIN and supplementing blood, and benefit essence fills out marrow, spleen reinforcing nourishing the stomach, and promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission, invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind；Adjuvant drug is the Rhizoma Anemarrhenae, Pericarpium Citri Reticulatae Viride, Fructus Lycii, Fructus Schisandrae Chinensis, Radix Ginseng, and clearing away heat-fire promotes the production of body fluid and moisturizes, soothing the liver dispelling the stagnated QI, and removing food stagnancyization is stagnant, restrains astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming；Making medicine is Radix Glycyrrhizae, invigorating the spleen and replenishing QI, coordinating the actions of various ingredients in a prescription.The all medicines of monarch coordinate, collaborative promotion, complement each other, are finally reached effect for the treatment of female climacteric syndrome.
Compared with prior art, the present invention has following technical advantage:
1, results of animal shows, pharmaceutical composition of the present invention can significantly increase Ovariectomized Rat Serum estradiol and reduce its follicle stimulating hormone content, it is seen then that castrated rats estrogen is significantly improved effect by medicine of the present invention；
2, pharmaceutical composition of the present invention is natural pure Chinese medicine composition, and toxic and side effects is little, female climacteric syndrome therapeutic effect is obvious, stable, and treatment cycle is short, relapse rate is low；
3, pharmaceutical composition of the present invention can enriching yin and nourishing kidney, nourishing blood for regulating menstruation, clearing away heart-fire for tranquillization, resolving heat and reducing pathogenic fire, invigorating spleen and reinforcing stomach and improve body constitution.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following example represents the technology playing good action in the practice of the invention that the inventors discovered that.But, disclosed specific embodiments can be made many changes, and still obtain same or analogous result, without deviating from the spirit and scope of the present invention.
Embodiment 1:
What the embodiment of the present invention 1 pharmaceutical composition included following parts by weight prepares raw material:
Folium Artemisiae Argyi 5 parts, Herba Leonuri 9 parts, Radix Angelicae Sinensis 3 parts, Radix Rehmanniae Preparata 9 parts, Rhizoma Dioscoreae 9 parts, 6 parts of Fructus Jujubae, the Rhizoma Anemarrhenae 6 parts, 3 parts of Pericarpium Citri Reticulatae Viride, Fructus Lycii 3 parts, Fructus Schisandrae Chinensis 3 parts, Radix Ginseng 3 parts and 1 part of Radix Glycyrrhizae.
Preparation method is as follows:
S1: weigh the ingredientss such as Folium Artemisiae Argyi, Herba Leonuri, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Jujubae, the Rhizoma Anemarrhenae, Pericarpium Citri Reticulatae Viride, Fructus Lycii, Fructus Schisandrae Chinensis, Radix Ginseng and Radix Glycyrrhizae by Chinese prescription respectively, pulverize respectively, standby；
S2: all medical materials are added the purified water of initial 10 times of weight of medical material, soaks 18 hours, decoct 2 hours, filter, add the purified water of 6 times of weight of medical material gross weight, decoct 2 hours, filter and retain filtering residue, merging filtrate, be concentrated into the concentrated solution that 60 DEG C of relative densities are 1.20 standby；
S3: the filtering residue of S2 is added the ethanol of the concentration 75% of 6 times of weight of medical material gross weight, reflux, extract, 2 times, each 2 hours, to filter, merging filtrate, decompression is distilled off ethanol, and it is standby to be concentrated into the concentrated solution that 60 DEG C of relative densities are 1.20；
S4: merged by the concentrated solution of S2, S3 gained, continuing to be concentrated into 60 DEG C of relative densities is the Chinese medical concrete of 1.33, obtains pharmaceutical composition extractum of the present invention；
S5: the Chinese medical concrete of S4 adds the conventional adjuvant of capsule, mixing, and blood pressure lowering dry, pulverize, and crosses 100 mesh sieves, loads in capsule shells, and every capsule medicated amount is 0.25g, obtains the capsule of the embodiment of the present invention 1 pharmaceutical composition.
Embodiment 2:
What the embodiment of the present invention 2 pharmaceutical composition included following parts by weight prepares raw material:
Folium Artemisiae Argyi 25 parts, Herba Leonuri 25 parts, Radix Angelicae Sinensis 25 parts, Radix Rehmanniae Preparata 15 parts, Rhizoma Dioscoreae 15 parts, 15 parts of Fructus Jujubae, the Rhizoma Anemarrhenae 12 parts, 9 parts of Pericarpium Citri Reticulatae Viride, Fructus Lycii 9 parts, Fructus Schisandrae Chinensis 6 parts, Radix Ginseng 6 parts and 12 parts of Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Embodiment 3:
What the embodiment of the present invention 3 pharmaceutical composition included following parts by weight prepares raw material:
Folium Artemisiae Argyi 15 parts, Herba Leonuri 16 parts, Radix Angelicae Sinensis 14 parts, Radix Rehmanniae Preparata 12 parts, Rhizoma Dioscoreae 12 parts, 12 parts of Fructus Jujubae, the Rhizoma Anemarrhenae 9 parts, 6 parts of Pericarpium Citri Reticulatae Viride, Fructus Lycii 6 parts, Fructus Schisandrae Chinensis 5 parts, Radix Ginseng 5 parts and 6 parts of Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Embodiment 4:
What the embodiment of the present invention 4 pharmaceutical composition included following parts by weight prepares raw material:
Folium Artemisiae Argyi 20 parts, Herba Leonuri 21 parts, Radix Angelicae Sinensis 19 parts, Radix Rehmanniae Preparata 13 parts, Rhizoma Dioscoreae 14 parts, 13 parts of Fructus Jujubae, the Rhizoma Anemarrhenae 10 parts, 7 parts of Pericarpium Citri Reticulatae Viride, Fructus Lycii 8 parts, Fructus Schisandrae Chinensis 5 parts, Radix Ginseng 5 parts and 9 parts of Radix Glycyrrhizae.
Preparation method is with embodiment 1.
The research experiment that castrated rats estrogen level is affected by pharmaceutical composition of the present invention
1, experimental drug: Chinese medicine capsules obtained by the embodiment of the present invention 3, embodiment 4, abolishes capsule shells, adds water and be modulated into magma.Positive control drug is Kuntai capsule (Guiyang Xintian Pharmaceutical Industry Co., Ltd., quasi-word Z20000083, the 0.5g*24 grain/box of traditional Chinese medicines), makees same process.
2, experiment animal used: SD rat, original body mass 225 ± 9g, female, female rats is all without pregnant.
3, experimental technique: take 108 SD rats, randomly draw 12 and be only used as Normal group, all the other 96 rats underwent bilateral oophorectomies, standby.The rat taking row ovarian resection after 3 months after operation is randomly divided into 8 groups, often group 12, respectively model control group, positive controls, the embodiment of the present invention 3 high dose group, middle dosage group, low dose group, the embodiment of the present invention 4 high dose group, middle dosage group, low dose group.High dose group of the present invention, middle dosage group and low dose group press 20g/kg, 10g/kg, 5g/kg dosage gastric infusion after packet, positive controls gives 20g/kg dosage gastric infusion, Normal group and model control group gavage and gives isometric normal saline.Once a day, successive administration 30 days.After last is administered two hours, abdomen arterial blood extracting prepares serum, detects serum estradiol and follicle stimulating hormone content with test kit.
4, experimental result: in Table 1.
The comparision contents of each serum hormone of table 1
Note: compare with Normal group,△P < 0.05,△△P < 0.01；Compare with model control group,*P < 0.05,**P < 0.01；Compare with positive controls,#P < 0.05,##P < 0.01.
5, experiment conclusion:
Model control group compares with Normal group, and the serum estradiol content of modeling rat reduces, and serum follicle stimulating hormone content raises, and has significant difference, and this experimental animal model modeling success is described.Experimental data shows, the present composition can be obviously improved modeling rat blood serum estradiol content, and can reduce the content of follicle stimulating hormone simultaneously, illustrates that castrated rats estrogen is significantly improved effect by medicine of the present invention, and action effect is better than positive controls.
The pharmaceutical composition of the present invention observation of curative effect to female climacteric syndrome clinical volunteers patient
One, diagnostic criteria
With reference to the diagnostic criteria of climacteric syndrome in People's Republic of China's traditional Chinese medicine industry standard " Chinese medical disease Standardization of diagnosis and curative effect ": 1, mostly occur more than 45 years old, irregular menses or amenorrhea, hectic fever, perspiration, cardiopalmus, emotional, insomnia or the symptom such as depressed；2, genitals and secondary sex characteristics have atrophy in various degree；3, urine, blood estrogen reduce, and follicle stimulating hormone and lutropin are significantly raised.
Two, criterion of therapeutical effect
With reference to the efficacy assessment standard of climacteric syndrome in People's Republic of China's traditional Chinese medicine industry standard " Chinese medical disease Standardization of diagnosis and curative effect ":
Cure: warm, sweating, the transference cure such as agitation, feel comfortable；
Effective: warm, sweating, the symptom such as agitation alleviate；
Invalid: after taking medicine, the state of an illness is unchanged.
Three, clinical trial
1, physical data
The female climacteric syndrome clinical volunteers patient that 300 selected is divided into 5 groups at random, often organize 60 people, respectively treatment A group, treatment B group, treatment C group, treatment D group and matched group, the age be 40-60 year, 45 years old mean age, respectively organize the influence factor such as age, symptom, through statistical procedures, there was no significant difference, meet packet condition.
2, Therapeutic Method
Treatment A group: take the capsule (0.25g*24 grain/box) that embodiment 1 prepares, every day 2 times, each 4, serve on 1 month；
Treatment B group: take the capsule (0.25g*24 grain/box) that embodiment 2 prepares, every day 2 times, each 4, serve on 1 month；
Treatment C group: take the capsule (0.25g*24 grain/box) that embodiment 3 prepares, every day 2 times, each 4, serve on 1 month；
Treatment D group: take the capsule (0.25g*24 grain/box) that embodiment 4 prepares, every day 2 times, each 4, serve on 1 month；
Matched group: take Kuntai capsule (Guiyang Xintian Pharmaceutical Industry Co., Ltd., quasi-word Z20000083, the 0.5g*24 grain/box of traditional Chinese medicines), one time 4,3 times on the one, serve on 1 month.
3, therapeutic outcome, as shown in table 2.
Table 2 therapeutic effect
4, conclusion (of pressure testing)
This test adopts Kuntai capsule as a control group, Kuntai capsule is meticulously refined by Chinese medicines such as Radix Rehmanniae Preparata, Rhizoma Coptidis, the Radix Paeoniae Alba, Radix Scutellariae, Colla Corii Asini, Poria and forms, there is nourishing YIN and clearing away heat, the effect of relieving restlessness of calming the nerves, cure mainly climacteric syndrome, by comparing with medicine composite for curing effect of the present invention, highlight the pharmaceutical composition of the present invention curative effect in treatment climacteric syndrome.Experimental data shows, the cure rate of medicine composite for curing A group of the present invention, treatment B group, treatment C group and treatment D group is all higher than 75%, total effective rate is all higher than 90%, therapeutic effect is significantly better than matched group, wherein, the pharmaceutical composition effect of the present invention prepared with treatment group C group and the embodiment of the present invention 3 is best.Visible, pharmaceutical composition good effect of the present invention, cure rate is high, it is possible to as the drug use for the treatment of climacteric syndrome.
Owing to describing the present invention already by above preferred embodiment, in the spirit and/or scope of the present invention, the present invention is implemented in any replacement/for the present invention or combination, will be apparent from for a person skilled in the art, and is included among the present invention.
Claims (7)
1. a pharmaceutical composition treats the purposes in female climacteric syndrome medicine in preparation, it is characterized in that, what described pharmaceutical composition included following parts by weight prepares raw material: Folium Artemisiae Argyi 5-25 part, Herba Leonuri 9-25 part, Radix Angelicae Sinensis 3-25 part, Radix Rehmanniae Preparata 9-15 part, Rhizoma Dioscoreae 9-15 part, Fructus Jujubae 6-15 part, Rhizoma Anemarrhenae 6-12 part, Pericarpium Citri Reticulatae Viride 3-9 part, Fructus Lycii 3-9 part, Fructus Schisandrae Chinensis 3-6 part, Radix Ginseng 3-6 part and Radix Glycyrrhizae 1-12 part.
2. the pharmaceutical composition as claimed in claim 1 purposes in preparation treatment female climacteric syndrome medicine, it is characterized in that, what described pharmaceutical composition included following parts by weight prepares raw material: Folium Artemisiae Argyi 5 parts, Herba Leonuri 9 parts, Radix Angelicae Sinensis 3 parts, Radix Rehmanniae Preparata 9 parts, Rhizoma Dioscoreae 9 parts, 6 parts of Fructus Jujubae, the Rhizoma Anemarrhenae 6 parts, 3 parts of Pericarpium Citri Reticulatae Viride, Fructus Lycii 3 parts, Fructus Schisandrae Chinensis 3 parts, Radix Ginseng 3 parts and 1 part of Radix Glycyrrhizae.
3. the pharmaceutical composition as claimed in claim 1 purposes in preparation treatment female climacteric syndrome medicine, it is characterized in that, what described pharmaceutical composition included following parts by weight prepares raw material: Folium Artemisiae Argyi 25 parts, Herba Leonuri 25 parts, Radix Angelicae Sinensis 25 parts, Radix Rehmanniae Preparata 15 parts, Rhizoma Dioscoreae 15 parts, 15 parts of Fructus Jujubae, the Rhizoma Anemarrhenae 12 parts, 9 parts of Pericarpium Citri Reticulatae Viride, Fructus Lycii 9 parts, Fructus Schisandrae Chinensis 6 parts, Radix Ginseng 6 parts and 12 parts of Radix Glycyrrhizae.
4. the pharmaceutical composition as claimed in claim 1 purposes in preparation treatment female climacteric syndrome medicine, it is characterized in that, what described pharmaceutical composition included following parts by weight prepares raw material: Folium Artemisiae Argyi 15 parts, Herba Leonuri 16 parts, Radix Angelicae Sinensis 14 parts, Radix Rehmanniae Preparata 12 parts, Rhizoma Dioscoreae 12 parts, 12 parts of Fructus Jujubae, the Rhizoma Anemarrhenae 9 parts, 6 parts of Pericarpium Citri Reticulatae Viride, Fructus Lycii 6 parts, Fructus Schisandrae Chinensis 5 parts, Radix Ginseng 5 parts and 6 parts of Radix Glycyrrhizae.
5. the pharmaceutical composition as claimed in claim 1 purposes in preparation treatment female climacteric syndrome medicine, it is characterized in that, what described pharmaceutical composition included following parts by weight prepares raw material: Folium Artemisiae Argyi 20 parts, Herba Leonuri 21 parts, Radix Angelicae Sinensis 19 parts, Radix Rehmanniae Preparata 13 parts, Rhizoma Dioscoreae 14 parts, 13 parts of Fructus Jujubae, the Rhizoma Anemarrhenae 10 parts, 7 parts of Pericarpium Citri Reticulatae Viride, Fructus Lycii 8 parts, Fructus Schisandrae Chinensis 5 parts, Radix Ginseng 5 parts and 9 parts of Radix Glycyrrhizae.
6. the purposes in preparation treatment female climacteric syndrome medicine of the pharmaceutical composition as described in any one of claim 1-5, it is characterised in that: described pharmaceutical composition is capsule, tablet, powder, granule, oral liquid or pill.
7. the purposes in preparation treatment female climacteric syndrome medicine of the pharmaceutical composition as described in any one of claim 1-5, it is characterised in that the preparation method of described pharmaceutical composition comprises the steps:
S1: weigh Folium Artemisiae Argyi, Herba Leonuri, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Jujubae, the Rhizoma Anemarrhenae, Pericarpium Citri Reticulatae Viride, Fructus Lycii, Fructus Schisandrae Chinensis, Radix Ginseng and Radix Glycyrrhizae, pulverize respectively, standby；
S2: all medical materials add the purified water of initial 8-12 times of weight of medical material, soaks 12-24 hour, decoct 1-3 hour, filters；Add the purified water of gross weight 5-9 times of weight of medical material, decoct 1-3 hour, filter and retain filtering residue, merging filtrate, be concentrated into the concentrated solution that 55 DEG C of-60 DEG C of relative densities are 1.20-1.25 standby；
S3: the filtering residue of S2 is added the ethanol of the concentration 65-80% of gross weight 5-7 times of weight of medical material, reflux, extract, 2-3 time, each 2-5 hour, to filter, merging filtrate, decompression is distilled off ethanol, and it is standby to be concentrated into the concentrated solution that 55 DEG C of-60 DEG C of relative densities are 1.20-1.25；
S4: merged by the concentrated solution of S2, S3 gained, continuing to be concentrated into 55 DEG C of-60 DEG C of relative densities is the Chinese medical concrete of 1.33-1.38, obtains pharmaceutical composition of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610191099.7A CN105796845A (en) | 2016-03-16 | 2016-03-16 | Application of medicine composition in preparing medicine for treating female climacteric syndromes |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610147287.XA CN105582274A (en) | 2016-03-16 | 2016-03-16 | Pharmaceutical composition for treating female climacteric syndrome and preparing method thereof |
| CN201610191099.7A CN105796845A (en) | 2016-03-16 | 2016-03-16 | Application of medicine composition in preparing medicine for treating female climacteric syndromes |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610147287.XA Division CN105582274A (en) | 2016-03-16 | 2016-03-16 | Pharmaceutical composition for treating female climacteric syndrome and preparing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105796845A true CN105796845A (en) | 2016-07-27 |
Family
ID=55922424
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610191099.7A Withdrawn CN105796845A (en) | 2016-03-16 | 2016-03-16 | Application of medicine composition in preparing medicine for treating female climacteric syndromes |
| CN201610147287.XA Withdrawn CN105582274A (en) | 2016-03-16 | 2016-03-16 | Pharmaceutical composition for treating female climacteric syndrome and preparing method thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610147287.XA Withdrawn CN105582274A (en) | 2016-03-16 | 2016-03-16 | Pharmaceutical composition for treating female climacteric syndrome and preparing method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN105796845A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213748A (en) * | 2015-09-30 | 2016-01-06 | 罗奕珺 | A kind of pharmaceutical composition for the treatment of female dimacteric syndrome and preparation method thereof |
| CN106890085A (en) * | 2017-01-23 | 2017-06-27 | 安徽绿莹彩龙艾绒制药有限公司 | A kind of medicine moxa-moxibustion of moxibustion climacteric metancholia |
| CN109007138A (en) * | 2018-10-16 | 2018-12-18 | 安徽明珍堂养生品有限公司 | A kind of concentration tea and preparation method thereof with qi-supplementing, blood-engendering effect |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213748A (en) * | 2015-09-30 | 2016-01-06 | 罗奕珺 | A kind of pharmaceutical composition for the treatment of female dimacteric syndrome and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104984296A (en) * | 2015-07-24 | 2015-10-21 | 青岛蓝盛洋医药生物科技有限责任公司 | Pharmaceutical composition for treating female climacteric syndrome and preparation method thereof |
| CN105169338A (en) * | 2015-10-10 | 2015-12-23 | 临沂草之美医药科技有限公司 | Medicine composition for treating female climacteric syndromes and preparation method thereof |
-
2016
- 2016-03-16 CN CN201610191099.7A patent/CN105796845A/en not_active Withdrawn
- 2016-03-16 CN CN201610147287.XA patent/CN105582274A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213748A (en) * | 2015-09-30 | 2016-01-06 | 罗奕珺 | A kind of pharmaceutical composition for the treatment of female dimacteric syndrome and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213748A (en) * | 2015-09-30 | 2016-01-06 | 罗奕珺 | A kind of pharmaceutical composition for the treatment of female dimacteric syndrome and preparation method thereof |
| CN106890085A (en) * | 2017-01-23 | 2017-06-27 | 安徽绿莹彩龙艾绒制药有限公司 | A kind of medicine moxa-moxibustion of moxibustion climacteric metancholia |
| CN109007138A (en) * | 2018-10-16 | 2018-12-18 | 安徽明珍堂养生品有限公司 | A kind of concentration tea and preparation method thereof with qi-supplementing, blood-engendering effect |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105582274A (en) | 2016-05-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102068625B (en) | Traditional Chinese medicinal composition for reducing blood sugar and blood pressure and preparation method thereof | |
| CN102078520B (en) | Chinese medicinal preparation for treating nervous headache and preparation method thereof | |
| CN105147847A (en) | Drug composition for benefiting qi and nourishing blood | |
| CN103041209B (en) | Chinese herbal preparation for curing deficiency of kidney-yin and preparation method thereof | |
| CN104922543A (en) | Medicine composite for treating amenorrhea and preparation method thereof | |
| CN104984297A (en) | Application of pharmaceutical composition in preparation of drugs for treating amenorrhea | |
| CN104940740A (en) | Traditional Chinese medicine composition for treating polycystic ovarian syndrome and preparation method thereof | |
| CN105796845A (en) | Application of medicine composition in preparing medicine for treating female climacteric syndromes | |
| CN108355088A (en) | A kind of spina date seed medicinal liquor and preparation method thereof improving sleep quality | |
| CN104491236A (en) | Traditional Chinese medicine preparation for treating essential hypertension and preparation method for traditional Chinese medicine preparation | |
| CN104984296A (en) | Pharmaceutical composition for treating female climacteric syndrome and preparation method thereof | |
| CN105194301A (en) | Traditional Chinese medicine preparation for treating chronic cardiac failure | |
| CN108904692A (en) | A method of preparing the Chinese medicine composition for the treatment of menopausal syndrome | |
| CN104524479B (en) | A kind of Chinese medicine composition for treating premenstrual syndrome and preparation method thereof | |
| CN105362629A (en) | Female climacteric syndrome treatment pharmaceutical composition containing cortex eucommiae and preparation method of female climacteric syndrome treatment pharmaceutical composition containing cortex eucommiae | |
| CN105213748A (en) | A kind of pharmaceutical composition for the treatment of female dimacteric syndrome and preparation method thereof | |
| CN105362630A (en) | Climacteric syndrome treatment pharmaceutical composition and preparation method thereof | |
| CN106361976A (en) | Compound preparation for calming nerves, promoting sleep and keeping beauty and preparation method of compound preparation | |
| CN105169338A (en) | Medicine composition for treating female climacteric syndromes and preparation method thereof | |
| CN105343675A (en) | Traditional Chinese medicine preparation for treating adiposis and preparation method thereof | |
| CN105288538A (en) | Application of medicine composition for preparing medicine for treating amenorrhea | |
| CN104324243A (en) | Traditional Chinese medicine preparation for treating female menopause insomnia | |
| CN104825892B (en) | A kind of Chinese medicine preparation for treating ovulation bleeding and preparation method thereof | |
| CN114712470B (en) | Medicine for treating deficiency of kidney of men and preparation method thereof | |
| CN114432410B (en) | Blood circulation promoting and stasis removing paste formula and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20160727 |