CN104906511A - Traditional Chinese medicine preparation for reflux esophagitis and preparation method of traditional Chinese medicine preparation - Google Patents
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Abstract
The invention discloses a traditional Chinese medicine preparation for reflux esophagitis. The traditional Chinese medicine preparation is prepared from the following raw materials: radix bupleuri processed with vinegar, radix curcumae, radix paeoniae alba, rhizoma cyperi processed with vinegar, schisandra chinensis, bryozoatum, calcined oyster shell, calcined concha arcae, cuttlebone, parched hawthorn fruit, roasted malt, roasted medicated leaven, codonopsis pilosula, poria cocos, roasted white atractylodes rhizome, fingered citron, perilla stem, gynostemma pentaphylla, rhodiola rosea, rhizoma nardostachyos, polygonum cuspidatum, fructus evodiae, rhizoma galangae and honey-fried licorice root. The traditional Chinese medicine preparation belongs to the field of traditional Chinese medicines. The traditional Chinese medicine preparation is prepared by the following steps: cleaning the raw materials, cutting into blocks, and carrying out pretreatment according to different characteristics of the traditional Chinese medicines; and preparing at the ratio by virtue of a special method. The traditional Chinese medicine preparation has the effects of tonifying the spleen, harmonizing the stomach, promoting the qi circulation, helping digestion, calming the liver, promoting the qi circulation, softening hard lumps and dispelling nodes, and is unique in combination and preparation method; through clinical verification, the traditional Chinese medicine preparation is significant in treatment effect, short in treatment cycle, low in price, and free of bad reaction or toxic or side effects, and has a wide market application prospect.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of for reflux esophagitis Chinese medicine preparation, the invention still further relates to the preparation method of this Chinese medicine preparation.
Background technology
Reflux esophagitis is frequently-occurring disease the most common in esophagel disease, means to cause the inflammation of distal esophagus mucosa into esophagus because stomach or intestinal contents backflow.The generation of primary disease is mainly due to lower esophageal sphincter malfunction, or the Closure insufficiency of sphincter of pylorus, causes acidic gastric juice or alkaline intestinal juice to backflow into esophagus, causes the dysfunction of esophagitis and esophagus.After main clinical manifestation has breastbone or burn feeling under xiphoid-process, burn sample pain, acataposis and gastrointestinal contents backflow.
Doctor trained in Western medicine mainly adopts acid suppression treatment or gastro-kinetic agent treatment or mucosa protection to treat, and carries out operative treatment if desired.The traditional Chinese medical science thinks that primary disease belongs to the category such as Chinese medicine " acid regurgitation ", " thoracic obstruction ", " gastric abscess ", " acid regurgitation ".How because feelings will is smooth, impairing the spleen and stomach, causes damp and hot heap soil or fertilizer over and around the roots and ties in middle Jiao, or the prolonged illness impairment of the spleen, the liver failing to dredge the spleen, causes incoordination between the spleen and stomach etc. and causes gas, the stasis of blood to tie in esophagus mutually, and logical the falling of stomach is obstructed, and occurs causalgia sense after acid regurgitation, belch, breastbone, very then eat counter go out.Chinese traditional treatment focuses on dialectical, distinguishes cold and heat and asthenia and sthenia, and Local Differentiation of Syndromes combines with whole body is dialectical in addition, treats with depressed liver-energy dispersing and QI regulating, and regulating the stomach and sending down the abnormal ascending QI is main, and strengthening vital QI to eliminate pathogenic factors, divides and rule.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation for reflux esophagitis, it is remarkable that this Chinese medicine preparation has therapeutic effect for treatment reflux esophagitis, and healing time is short, cheap, has no adverse reaction and the feature of secondary toxic action.
Inventor is in clinical treatment practice for many years, and according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out to be used for the treatment of the new formula of the Chinese medicine preparation of reflux esophagitis repeatedly.The present invention has that therapeutic effect is remarkable, and healing time is short, cheap, has no adverse reaction and the feature of secondary toxic action.
The effect of Chinese medicine of the present invention:
Wherein:
Radix Bupleuri (processed with vinegar): be the dry root vinegar goods of umbelliferae bupleurum Bupleurum chinense DC. or Radix Bupeuri Scorzonerfolii. Bupleurum scorzonerifolium Willd..Nature and flavor: bitter, are slightly cold.Return liver, gallbladder meridian.Effect: reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.Record in " detailed outline ": control yang-energy and sink, suppressing the hyperactive liver, gallbladder, three burnt, envelope is mutually fiery.
Radix Curcumae: be the dried root of zingiberaceous plant RADIX CURCUMAE Curcuma wenyujin Y. H. Chen et C. Ling, Rhizoma Curcumae Longae Curcuma longa L., Guangxi zedoary Curcuma kwangsiensis S. G. Lee et C. F. Liang or Rhizoma Curcumae Curcuma phaeocaulis Val..Nature and flavor: pungent, bitter, cold.Return liver, the heart, lung meridian.Effect: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.Record in essentials of Matea Medica: " circulation of qi promoting, resolving depression; Let out blood, removing blood stasis with potent drugs.Cool heat in the heart, loose stagnation of liver-QI.
The Radix Paeoniae Alba: be the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Nature and flavor: bitter, sour, are slightly cold.Return liver, spleen channel.Effect: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.Record in " herbal classic ": main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, control cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating.
Rhizoma Cyperi: be the dry rhizome of sedge dried tuber Cyperus rotundus L..Nature and flavor: pungent, micro-hardship, micro-sweet are flat.Return liver, spleen, tri-jiao channel.Effect: promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.Record in " detailed outline ": loose seasonal epidemic pathogens is trembled with fear epidemic disease, and profit three is burnt, and separate six kinds of stagnation-syndromes, the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, ulcer sores, spits blood, hematochezia, hematuria, married woman's bleeding not during menses, the moon wait uncomfortable, before tire puerperal all kinds of diseases and ailments.
Fructus Schisandrae Chinensis: be the dry mature fruit of magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill. or schisandra chinensis Schisandra sphenanthera Rehd. et Wils..Nature and flavor: sour, sweet, temperature.Return lung, the heart, kidney channel.Effect: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Pumex: the stone that the magma gone out for volcanic eruption is formed.Nature and flavor: salty, cold.Effect: removing heat from the lung and dissipating phlegm, hard masses softening and resolving.For cough due to lung-heat, yellowish thick sputum, spitting of blood, bronchitis, tuberculous lymphadenitis.Record in " detailed outline ": the goiter that disappears tuberculosis hernia, the therapeutic method to keep the adverse QI flowing downwards, the skin ulcer that disappears swells.
Concha Ostreae: be the shell of Ostreidae animal long Concha Ostreae Ostrea gigas Thunberg, Dalian Bay Concha Ostreae Ostrea talienwhanensis Crosse or Crassostrea rivularis Ostrea rivularis Gould.Nature and flavor: salty, are slightly cold.Return liver, gallbladder, kidney channel.Effect: tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving.For insomnia of palpitating with fear, vertigo and tinnitus, scrofula sucutaneous nodule, lump in the abdomen mass in the abdomen.Concha Ostreae (calcined) convergence is astringent or styptic treatment for spontaneous sweating.For spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache acid regurgitation.Record in " herbal classic ": typhoid fever cold and heat, pyrexial malaria is voluminous, frightened gas of being enraged, and except arresting slow scrofula, woman's leukorrhagia is in vain red.Take bone strengthening joint for a long time.
Concha Arcae: be the shell of Carnis Arca inflata section animal Scapharca subcrenata Arca subcrenata Lischke, Tegillarca granosa Arca granosa Linnaeus or Scapharca broughtonii Arca inflata Reeve.Nature and flavor: salty are flat.Return lung, stomach, Liver Channel.Effect: expectorant blood stasis dispelling, hard masses softening and resolving, relieving gastric hyperacidity to alleviate stomachache.For the long-pending knot of pertinacious phlegm, sticky difficulty is coughed up, goiter, scrofula, lump in the abdomen mass in the abdomen, stomachache pantothenic acid.Record in " Japan hanako materia medica ": burnt quench in vinegar, vinegar ball takes, and controls all vim and vigour, cold air, disease addiction.
Endoconcha Sepiae: be the dry inner shell of Sepiidae animal sepiella maindroni de Rochebrune Sepiella maindroni de Rochebrune or golden cuttlefish Sepia esculenta Hoyle.Nature and flavor: salty, puckery, temperature.Return spleen, kidney channel.Effect: astringing to arrest bleeding, relieving leukorrhea by astringents, antacid, sore.For acid regurgitation of having a stomachache, hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge; Peptic Ulcers.External treatment bleeding due to trauma, the many pus of skin ulcer.Record in " not Lu ": frightened gas enters abdomen, stomachache ring umbilicus, edema due to cold pathogen in the moon (one does " swell and ache in husband's the moon "), only the many pus of skin ulcer are not dry again.
Fructus Crataegi (parched): be the processed product of the dry mature fruit of rosaceous plant Fructus Pyri Pashiae Crataegus pinnatifida Bge.var.major N.E.Br. or Fructus Crataegi Crataegus pinnatifida Bge..Nature and flavor: sour, sweet, tepor.Return spleen, stomach, Liver Channel.Effect: promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, gastral cavilty distension, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens.For meat stagnation, dysentery is not well.Record in " book on Chinese herbal medicine is new again ": control insufficiency of the spleen damp and hot, the mill that helps digestion is long-pending, sharp defecation.
Fructus Hordei Germinatus (parched): for the mature fruit of grass Fructus Hordei Vulgaris Hordeum vulgare L. through germination dry product through making.Nature and flavor: sweet are flat.Return spleen, stomach warp.Effect: promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, moves back newborn relieving distension.Do not disappear for food stagnation, abdominal distention, insufficiency of the spleen lack of appetite, milk smoulders, distending pain of the breast, and women weans." Japan hanako materia medica " is in record: " appetizing, only cholera, relieving restlessness, expectorant ， Po Disorder ties, and can expedite the emergence of tire for warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards.
Massa Medicata Fermentata: for the medicines such as Herba polygoni hydropiperis, Herba Artemisiae Annuae, Semen Armeniacae Amarum add flour or wheat bran mixed after, through the herbal leaven of fermentation.Massa Medicata Fermentata preparata is the processed product of Massa Medicata Fermentata.Nature and flavor: sweet, pungent, warm, nontoxic.Return spleen; Stomach is through effect: invigorating the spleen and regulating the stomach; Promoting digestion and removing stagnation.Main retention of food and drink; Dyspepsia; Distension and fullness in the abdomen; Inappetence; Vomiting dysentery.Record in " book on Chinese herbal medicine is stated ": cure the wound summer-heat, being affected by fluid-retention is eaten, and hinders overstrain, and malaria flatulence due to stagnation of QI is demonstrate,proved, and edema distension gathers, cough due to fluid-retention, and vomiting regurgitation, cholera, blood-retention, pained, gastric abscess, hypochondriac pain, numbness flaccidity is dizzy, heavy sensation of the body, can not eat, jaundice.
Radix Codonopsis: be the dry root of Campanulaceae Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., element flower Radix Codonopsis (RADIX CODONOPSIS PILOSULAE from Northwest of China) Codonopsis pilosula Nannf. var. modesta (Nannf.) L. T. Shen or radix codonpsis tangshen Codonopsis tangshen Oliv..Nature and flavor: sweet are flat.Return spleen, lung meridian.Effect: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
Poria: be the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Nature and flavor: sweet, light are flat.GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.Record in " Japan hanako materia medica ": mend five kinds of strain and seven kinds of impairment, antiabortive, warm waist knee joint, happy Fructus Alpiniae Oxyphyllae, only forgetful.
Rhizoma Atractylodis Macrocephalae (parched): be the processed product of the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Nature and flavor: bitter, sweet, temperature.Return spleen, stomach warp.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.Record in " herbal classic ": main anemofrigid-damp arthralgia, dead flesh, convulsion, subcutaneous ulcer, hidroschesis, heat extraction helps digestion.
Fructus Citri Sarcodactylis: be the dry fruit of Rutaceae citrus plant Fructus Citri Sarcodactylis Citrus medica L. var. sarcodactylis Swingle.Nature and flavor: pungent, bitter, sour, temperature.Return liver, spleen, lung meridian.Effect: liver-smoothing, qi-regulating, and stomach and alleviating pain.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite is vomitted.
Caulis Perillae: be the dry stem of labiate Folium Perillae Perilla frutescens (L.) Britt..Nature and flavor: pungent, temperature.Return lung, spleen channel.Effect: regulating the flow of QI to ease the stomach, pain relieving, antiabortive.Vexed for chest and diaphragm painful abdominal mass, gastralgia, belch is vomitted, frequent fetal movement.Record in " must book on Chinese herbal medicine be joined ": soothing the liver, sharp lung, regulates the flow of vital energy, and blood, resolving depression, and pain relieving is coughed surely, antiabortive.
Herb Gynostemmae Pentaphylli: be cucurbitaceae genus gynostemma Herb Gynostemmae Pentaphylli Gynostemma pentaphyllum (Thunb.) Makino, be used as medicine with root stock.Nature and flavor: bitter in the mouth; Micro-sweet; Cool in nature, return lung; Spleen; Kidney channel effect: heat clearing away; Tonify deficiency; Removing toxic substances.Main body void is weak; Nephrasthenia emission; Leukopenia; Hyperlipemia; Viral hepatitis; Chronic gastroenteritis; Chronic tracheitis.
Radix Rhodiolae: be Crassulaceae Rhodida plant Radix Rhodiolae Rhodiola saera (Prain) Fu, with all herbal medicine.9 ~ October gathers, and cleans and dries.Nature and flavor: sweet, puckery, cold.Return lung meridian.Effect: clearing away lung-heat to relieve cough, hemostasis, leukorrhagia stopping.For cough due to lung-heat, spitting of blood, leucorrhea; Traumatic injury is controlled in external, burn and scald.
Radix Et Rhizoma Nardostachyos: be the dry root and rhizome of Valerianaceae plant Radix Et Rhizoma Nardostachyos Nardostachys chinensis Batal. or spoon Ye Gansong Nardos-tachys jatamansi DC..Nature and flavor: acrid, sweet, warm.Return spleen, stomach warp.Effect: regulating QI to relieve pain, relieving stagnation and activating the spleen.For distension and fullness in the abdomen, inappetence, vomiting; External treatment is had a toothache, swelling of the feet.Record in " Kaibao Bencao ": main bad odor, soldier's cardiac and abdominal pain is full.
Rhizoma Polygoni Cuspidati: be polygonaceae plant Rhizoma Polygoni Cuspidati Polygonum cuspidatum Sieb. et Zucc., dry rhizome and root.Nature and flavor: micro-hardship, is slightly cold.Return liver, gallbladder, lung meridian.Effect: expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea, lump in the abdomen, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus, cough with copious phlegm.Record in " Guizhou side's medicine among the people collection ": astringing to arrest bleeding, control hemorrhoid complicated by anal fistula, curing rheumatism, deliver cold expelling, dissipating blood stasis blood.
Fructus Evodiae: be rutaceae Fructus Evodiae Evodia rutaecarpa(Juss.) Benth., Shi Hu Evodia rutaecarpa(Juss.) the dry almost ripe fruit of Benth. var. officinalis (Dode) Huang or thin hair Fructus Evodiae Evodia rutaecarpa (Juss.) Benth. var. bodinieri (Dode) Huang.Nature and flavor: pungent, bitter, heat; Slightly poisonous.Return liver, spleen, stomach, kidney channel.Effect: dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.For headache due to JUE YIN disorder, colic of cold type is suffered from abdominal pain, the disturbance of lower legs due to pathogenic cold and dampness, abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation, Diarrhoea, external treatment aphtha; Hypertension.Record in " herbal classic ": main warming the middle warmer and descending qi, pain relieving, cough with dyspnea cold and heat, dehumidifying arthralgia due to stagnation of blood, by ailment said due to cold or exposure, loosing the interspaces of skin and muscles.
Rhizoma Alpiniae Officinarum: be the dry rhizome of zingiberaceous plant Rhizoma Alpiniae Officinarum Alpinia officinarum Hance.Nature and flavor: pungent, heat.Return spleen, stomach warp.Effect: warming stomach for dispelling cold, help digestion pain relieving.For coldness and pain in the epigastrium, gastrofrigid vomiting, belch acid regurgitation.Record in supplement to the Herbal: the therapeutic method to keep the adverse QI flowing downwards, beneficial sound.Boil do drink-service it, dysentery relieving and cholera.
Radix Glycyrrhizae Preparata: be the Preparation process product of Radix Glycyrrhizae.Nature and flavor: sweet are flat.GUIXIN, lung, spleen, stomach warp.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery.For weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.
Side's solution of the present invention is: Fructus Crataegi (parched) promoting digestion and invigorating the stomach in side, Fructus Hordei Germinatus (parched) promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, Massa Medicata Fermentata preparata invigorating the spleen and regulating the stomach, promoting digestion and removing stagnation, Radix Codonopsis invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, Poria spleen invigorating mind calming, Rhizoma Atractylodis Macrocephalae (parched) invigorating the spleen and benefiting QI, Fructus Citri Sarcodactylis regulating qi-flowing for harmonizing stomach, Caulis Perillae regulating the flow of QI to ease the stomach, Herb Gynostemmae Pentaphylli heat clearing away tonify deficiency, Radix Et Rhizoma Nardostachyos is regulated the flow of vital energy and is amusing, Fructus Evodiae warming the middle warmer and descending qi, Rhizoma Alpiniae Officinarum stomach warming helps digestion, and above 12 taste medicines are as monarch drug in side, all return spleen, stomach warp, there is the effect of invigorating the spleen and regulating the stomach, promote qi circulation digestion promoting.The traditional Chinese medical science think primary disease many due to feelings will smooth, impairing the spleen and stomach, causes damp and hot heap soil or fertilizer over and around the roots and ties in middle Jiao, or the prolonged illness impairment of the spleen, the liver failing to dredge the spleen, causes incoordination between the spleen and stomach etc. and causes gas, the stasis of blood to tie in esophagus mutually, logical the falling of stomach is obstructed, and occurs causalgia sense after acid regurgitation, belch, breastbone, very then eat counter go out.So invigorating the spleen and regulating the stomach, promote qi circulation digestion promoting are the bases for the treatment of reflux esophagitis, above 12 taste medicines are monarch drug, and first fundamentally invigorating the spleen and regulating the stomach, promote qi circulation digestion promoting makes disease obtain basic control.
Concha Arcae (calcined), Concha Ostreae (calcined), Pumex hard masses softening and resolving, Endoconcha Sepiae antacid sore, Fructus Schisandrae Chinensis supplementing QI for promoting the production of body fluid, kidney calming, ministerial drug in the above five kinds of Chinese medicine side of being, returns kidney, Liver Channel.Auxiliary monarch drug invigorating the spleen and regulating the stomach, promote qi circulation digestion promoting on the one hand; There is as ministerial drug effect of hard masses softening and resolving on the other hand.
Radix Bupleuri (processed with vinegar) is conciliate soothing the liver, Rhizoma Cyperi (processed with vinegar), Radix Curcumae promoting QI circulation for relieving depression, the regulating menstruation of Radix Paeoniae Alba suppressing the hyperactive liver, Rhizoma Polygoni Cuspidati expelling wind and removing dampness, dissipating blood stasis analgesic therapy, Radix Rhodiolae lung heat clearing leukorrhagia stopping, and above Six-element medicine returns liver, spleen channel, liver controlling conveyance and dispersion, the stomach propelling food downward, and The spleen has the function to transport and transform nutrients; Liver storing blood, spleen governing blood is again source of generating QI and blood.Irritability catharsis is too late, is exactly depression of liver-QI.Stagnation of liver-QI is wood failing to restrict earth then, can affect taste and be elevated normally and receive fortune function, and cause diet water paddy to transfer cloth fortune obstacle and burntly in occurring stop up full, namely stagnation of liver-QI spleen is stopped up; If main manifestations is the obstacle of spleen in transmitting and distributing the fluids function, namely stagnation of liver-QI spleen wets.As adjuvant drug, cause the inducement of reflux esophagitis from pathology treatment, the invigorating the spleen and regulating the stomach of the monarch and his subjects two medicine, effect of promote qi circulation digestion promoting can be promoted as adjuvant drug, effect of the circulation of qi promoting of body suppressing the hyperactive liver, hard masses softening and resolving can be promoted by using corrigent the monarch and his subjects two medicine again.Radix Glycyrrhizae Preparata makes medicine as in side, has the effect of coordinating the actions of various ingredients in a prescription, mediation flavour of a drug.The all medicines of this side share, and the monarch and his subjects pull together, and minister assistant is auxiliary altogether, has effect of invigorating the spleen and regulating the stomach, promote qi circulation digestion promoting, suppressing the hyperactive liver circulation of qi promoting, hard masses softening and resolving, effectively can treat reflux esophagitis.
Another important feature of the present invention is that this Chinese medicine preparation contains abundant nutritional labeling, be rich in aminoacid and have more than 17 kinds, wherein essential amino acid has threonine, valine, methionine, isoleucine, leucine, lysine and phenylalanine, trace element containing needed by human has ferrum, chromium, copper, boron, manganese, strontium and zinc, several human body macroelement of another calcic, potassium, magnesium, phosphorus.Above nutritional labeling is all needed by human material, effectively can strengthen body immunity.
Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Radix Bupleuri (processed with vinegar) 13-17 part, Radix Curcumae 10-14 part, Radix Paeoniae Alba 13-17 part, Rhizoma Cyperi (processed with vinegar) 13-17 part, Fructus Schisandrae Chinensis 10-14 part, Pumex 22-26 part, Concha Ostreae (calcined) 22-26 part, Concha Arcae (calcined) 22-26 part, Endoconcha Sepiae 13-17 part, Fructus Crataegi (parched) 13-17 part, Fructus Hordei Germinatus (parched) 13-17 part, Massa Medicata Fermentata preparata 13-17 part, Radix Codonopsis 16-20 part, Poria 16-20 part, Rhizoma Atractylodis Macrocephalae (parched) 22-26 part, Fructus Citri Sarcodactylis 13-17 part, Caulis Perillae 18-22 part, Herb Gynostemmae Pentaphylli 13-17 part, Radix Rhodiolae 13-17 part, Radix Et Rhizoma Nardostachyos 10-14 part, Rhizoma Polygoni Cuspidati 18-22 part, Fructus Evodiae 4-8 part, Rhizoma Alpiniae Officinarum 7-11 part, Radix Glycyrrhizae Preparata 7-11 part.
Wherein be preferably: Radix Bupleuri (processed with vinegar) 15 parts, Radix Curcumae 12 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Cyperi (processed with vinegar) 15 parts, Fructus Schisandrae Chinensis 12 parts, Pumex 24 parts, Concha Ostreae (calcined) 24 parts, Concha Arcae (calcined) 24 parts, Endoconcha Sepiae 15 parts, Fructus Crataegi (parched) 15 parts, Fructus Hordei Germinatus (parched) 15 parts, Massa Medicata Fermentata preparata 15 parts, Radix Codonopsis 18 parts, 20 parts, Poria, Rhizoma Atractylodis Macrocephalae (parched) 24 parts, Fructus Citri Sarcodactylis 15 parts, Caulis Perillae 20 parts, Herb Gynostemmae Pentaphylli 15 parts, Radix Rhodiolae 15 parts, Radix Et Rhizoma Nardostachyos 12 parts, Rhizoma Polygoni Cuspidati 20 parts, Fructus Evodiae 6 parts, Rhizoma Alpiniae Officinarum 9 parts, Radix Glycyrrhizae Preparata 9 parts.
A kind of preparation method of the Chinese medicine preparation for reflux esophagitis is as follows:
Step one: by weight of the present invention, gets Radix Bupleuri (processed with vinegar), Rhizoma Cyperi (processed with vinegar), Fructus Crataegi (parched), Fructus Hordei Germinatus (parched), Massa Medicata Fermentata preparata, Rhizoma Atractylodis Macrocephalae (parched), Concha Ostreae (calcined), Concha Arcae (calcined), Endoconcha Sepiae, pulverizes, and crosses 120 mesh sieves, for subsequent use;
Step 2: by weight proportion of the present invention, get Radix Curcumae, the Radix Paeoniae Alba, Pumex, Radix Codonopsis, Poria, Caulis Perillae, Herb Gynostemmae Pentaphylli, Radix Et Rhizoma Nardostachyos, Rhizoma Polygoni Cuspidati, Alpinia Officinarum be placed in marmite, add the water of 8 times of volumes, intense fire infusion is after 20-30 minute, add Radix Rhodiolae, Radix Glycyrrhizae Preparata and respectively with Fructus Schisandrae Chinensis, Fructus Evodiae, Fructus Citri Sarcodactylis intense fire infusion 10-20 minute that bundle ties, fiery infusion of larding speech with literary allusions obtains filtrate in 30 ~ 40 minutes, and infusion merges gained filtrates three times repeatedly, for subsequent use;
Step 3: by step 2 gained filtrate and step one gained powder mixing, stir evenly, both treatment reflux esophagitis decoction of the present invention.
Using method of the present invention: get an auxiliary medicine agent, ante cibum, warm water was taken, every day three times.
Medicine of the present invention has the effect of invigorating the spleen and regulating the stomach, promote qi circulation digestion promoting, suppressing the hyperactive liver circulation of qi promoting, hard masses softening and resolving, and good analgesic effect, cheap, have no side effect, easy to use, the mode that this Chinese medicine preparation adopts is treated and can be reduced the injury of Western medicine to patient body, alleviate the slight illness of patient, according to clinical 240 routine patient view statistics, use medicine of the present invention the total effective rate course for the treatment of 82.5%, two the total effective rate course for the treatment of 95%.
Detailed description of the invention
Embodiment one: Radix Bupleuri (processed with vinegar) 15 parts, Radix Curcumae 12 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Cyperi (processed with vinegar) 15 parts, Fructus Schisandrae Chinensis 12 parts, Pumex 24 parts, Concha Ostreae (calcined) 24 parts, Concha Arcae (calcined) 24 parts, Endoconcha Sepiae 15 parts, Fructus Crataegi (parched) 15 parts, Fructus Hordei Germinatus (parched) 15 parts, Massa Medicata Fermentata preparata 15 parts, Radix Codonopsis 18 parts, 20 parts, Poria, Rhizoma Atractylodis Macrocephalae (parched) 24 parts, Fructus Citri Sarcodactylis 15 parts, Caulis Perillae 20 parts, Herb Gynostemmae Pentaphylli 15 parts, Radix Rhodiolae 15 parts, Radix Et Rhizoma Nardostachyos 12 parts, Rhizoma Polygoni Cuspidati 20 parts, Fructus Evodiae 6 parts, Rhizoma Alpiniae Officinarum 9 parts, Radix Glycyrrhizae Preparata 9 parts.
Embodiment two: Radix Bupleuri (processed with vinegar) 16 parts, Radix Curcumae 11 parts, the Radix Paeoniae Alba 14 parts, Rhizoma Cyperi (processed with vinegar) 15 parts, Fructus Schisandrae Chinensis 12 parts, Pumex 25 parts, Concha Ostreae (calcined) 23 parts, Concha Arcae (calcined) 24 parts, Endoconcha Sepiae 16 parts, Fructus Crataegi (parched) 15 parts, Fructus Hordei Germinatus (parched) 16 parts, Massa Medicata Fermentata preparata 14 parts, Radix Codonopsis 19 parts, 20 parts, Poria, Rhizoma Atractylodis Macrocephalae (parched) 24 parts, Fructus Citri Sarcodactylis 15 parts, Caulis Perillae 20 parts, Herb Gynostemmae Pentaphylli 14 parts, Radix Rhodiolae 15 parts, Radix Et Rhizoma Nardostachyos 12 parts, Rhizoma Polygoni Cuspidati 21 parts, Fructus Evodiae 7 parts, Rhizoma Alpiniae Officinarum 10 parts, Radix Glycyrrhizae Preparata 10 parts.
Embodiment three: Radix Bupleuri (processed with vinegar) 17 parts, Radix Curcumae 11 parts, the Radix Paeoniae Alba 14 parts, Rhizoma Cyperi (processed with vinegar) 15 parts, Fructus Schisandrae Chinensis 12 parts, Pumex 25 parts, Concha Ostreae (calcined) 25 parts, Concha Arcae (calcined) 25 parts, Endoconcha Sepiae 15 parts, Fructus Crataegi (parched) 14 parts, Fructus Hordei Germinatus (parched) 14 parts, Massa Medicata Fermentata preparata 15 parts, Radix Codonopsis 18 parts, 20 parts, Poria, Rhizoma Atractylodis Macrocephalae (parched) 26 parts, Fructus Citri Sarcodactylis 14 parts, Caulis Perillae 20 parts, Herb Gynostemmae Pentaphylli 13 parts, Radix Rhodiolae 14 parts, Radix Et Rhizoma Nardostachyos 13 parts, Rhizoma Polygoni Cuspidati 21 parts, Fructus Evodiae 8 parts, Rhizoma Alpiniae Officinarum 8 parts, Radix Glycyrrhizae Preparata 8 parts.
Just the clinical statistics data that patient uses medicine of the present invention below:
One, physical data
Accept out-patient 240 example for medical treatment, patient is divided at random observation group and each 120 examples of matched group, wherein male 120 example, women 120 example, M-F 1:1, max age 66 years old, minimal ages 20 years old, the course of disease several months to several years is not etc.Every basic documents such as two groups of patient ages, sex, courses of disease are substantially identical, no significant difference (P > 0.05).
Two, diagnostic criteria
All there is following any one or more person all can be diagnosed as reflux esophagitis through the be unequivocally established patient of abnormal acid reflux of 24 hours esophagus PH dynamic monitoring.
1, the classical symptom of gastroesophageal reflux or Non-typical symptoms.2, gastroscopy has 1-1V level esophagitis Symptoms.
3, get rid of gestation, after cardia excision, cardia achalasia, pyloric obstruction, total gastrectomy postoperative, sliding hiatal hernia, the esophageal carcinoma.
Three, Therapeutic Method:
1, observation group is according to Medications Example one of the present invention, and weighting raw materials is by the treatment of invention implementation method, and agent of getting it filled, ante cibum, warm water was taken, every day three times.It within 7 days, is a course for the treatment of.
2, matched group adopts Routine control: gastro-kinetic agent Western medicine motilium is treated, and every day three times seven days is a course for the treatment of.
Four, efficacy assessment standard:
1, cure: the transference cure such as heartburn, chest pain, dysphagia, regurgitation.Drug withdrawal is observed and is not recurred half a year.24 hours esophagus PH dynamic monitoring acid reflux without exception.The classification of gastroscopy esophagitis reduces by more than 1 grade.
2, take a turn for the better: the symptom partial disappearance such as heartburn, chest pain, dysphagia, regurgitation.24 hours esophagus PH dynamic monitoring has or acid reflux without exception.The classification of gastroscopy esophagitis reduces by more than 1 grade.3, invalid: symptom and check result are without improvement.
Five, therapeutic outcome statistics:
Matched group result is added up
Use the Comparison of therapeutic situation of this Chinese medicine preparation two groups of patients, two courses for the treatment of
Wherein: total effective rate=cure rate+improvement rate
Can find that observation group is apparently higher than matched group by the treatment total effective rate contrasting two groups of patients, illustrate thus, Chinese medicine of the present invention has good clinical effectiveness in treatment reflux esophagitis, effectively can improve the cure rate for the treatment of, Be very effective, cheap, have no adverse reaction and any toxic and side effects, there is wide market application foreground.
Model case and curative effect:
Case one, patient Wang, female, 46 years old, people from Qingdao City, came here and goes to a doctor on January 20th, 2010.Because of gastral cavilty portion pain, with heartburn, acid regurgitation water, recurrent exerbation 2 years.Motilium is taken and ranitidine is effective when having an attack of one's old illness.Fall ill again before two weeks, done detailed inspection in my institute, be diagnosed as reflux esophagitis.Adopt made preparation in the embodiment of the present invention one, and selected preparation method, after two courses for the treatment of of treatment, effect is very good, and in esophagus, to measure gastroscopy all normal for pH value.Follow up a case by regular visits to after 2 years and do not recur.
Case two, patient Lee, man, 39 years old, people from Linyi, Shandong.Come here on May 14th, 2010 to go to a doctor, symptom is as follows after diagnosing: heartburn, nauseating, esophagus burning sensation is with heartburn, acid regurgitation water.Stool is normal, and oliguria with reddish urine, body of the tongue is light red, and tongue fur BOHUANG, is diagnosed as reflux esophagitis.Adopt made preparation in the embodiment of the present invention one, and selected preparation method, after two courses for the treatment of of treatment, effect is very good, and in esophagus, to measure gastroscopy all normal for pH value.Follow up a case by regular visits to after 1 year and do not recur.
Claims (4)
1. one kind for reflux esophagitis Chinese medicine preparation, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Radix Bupleuri (processed with vinegar) 13-17 part, Radix Curcumae 10-14 part, Radix Paeoniae Alba 13-17 part, Rhizoma Cyperi (processed with vinegar) 13-17 part, Fructus Schisandrae Chinensis 10-14 part, Pumex 22-26 part, Concha Ostreae (calcined) 22-26 part, Concha Arcae (calcined) 22-26 part, Endoconcha Sepiae 13-17 part, Fructus Crataegi (parched) 13-17 part, Fructus Hordei Germinatus (parched) 13-17 part, Massa Medicata Fermentata preparata 13-17 part, Radix Codonopsis 16-20 part, Poria 16-20 part, Rhizoma Atractylodis Macrocephalae (parched) 22-26 part, Fructus Citri Sarcodactylis 13-17 part, Caulis Perillae 18-22 part, Herb Gynostemmae Pentaphylli 13-17 part, Radix Rhodiolae 13-17 part, Radix Et Rhizoma Nardostachyos 10-14 part, Rhizoma Polygoni Cuspidati 18-22 part, Fructus Evodiae 4-8 part, Rhizoma Alpiniae Officinarum 7-11 part, Radix Glycyrrhizae Preparata 7-11 part.
2. the Chinese medicine preparation for reflux esophagitis according to claim 1, it is characterized in that, be made up of the medicine of following weight portion: Radix Bupleuri (processed with vinegar) 15 parts, Radix Curcumae 12 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Cyperi (processed with vinegar) 15 parts, Fructus Schisandrae Chinensis 12 parts, Pumex 24 parts, Concha Ostreae (calcined) 24 parts, Concha Arcae (calcined) 24 parts, Endoconcha Sepiae 15 parts, Fructus Crataegi (parched) 15 parts, Fructus Hordei Germinatus (parched) 15 parts, Massa Medicata Fermentata preparata 15 parts, Radix Codonopsis 18 parts, 20 parts, Poria, Rhizoma Atractylodis Macrocephalae (parched) 24 parts, Fructus Citri Sarcodactylis 15 parts, Caulis Perillae 20 parts, Herb Gynostemmae Pentaphylli 15 parts, Radix Rhodiolae 15 parts, Radix Et Rhizoma Nardostachyos 12 parts, Rhizoma Polygoni Cuspidati 20 parts, Fructus Evodiae 6 parts, Rhizoma Alpiniae Officinarum 9 parts, Radix Glycyrrhizae Preparata 9 parts.
3. the Chinese medicine preparation for reflux esophagitis according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is decoction.
4. the preparation method for the Chinese medicine preparation of reflux esophagitis, it is characterized in that, preparation method is as follows: step one: by weight of the present invention, get Radix Bupleuri (processed with vinegar), Rhizoma Cyperi (processed with vinegar), Fructus Crataegi (parched), Fructus Hordei Germinatus (parched), Massa Medicata Fermentata preparata, Rhizoma Atractylodis Macrocephalae (parched), Concha Ostreae (calcined), Concha Arcae (calcined), Endoconcha Sepiae, pulverize, cross 120 mesh sieves, for subsequent use; Step 2: by weight proportion of the present invention, get Radix Curcumae, the Radix Paeoniae Alba, Pumex, Radix Codonopsis, Poria, Caulis Perillae, Herb Gynostemmae Pentaphylli, Radix Et Rhizoma Nardostachyos, Rhizoma Polygoni Cuspidati, Alpinia Officinarum be placed in marmite, add the water of 8 times of volumes, intense fire infusion is after 20-30 minute, add Radix Rhodiolae, Radix Glycyrrhizae Preparata and respectively with Fructus Schisandrae Chinensis, Fructus Evodiae, Fructus Citri Sarcodactylis intense fire infusion 10-20 minute that bundle ties, fiery infusion of larding speech with literary allusions obtains filtrate in 30 ~ 40 minutes, and infusion merges gained filtrates three times repeatedly, for subsequent use; Step 3: by step 2 gained filtrate and step one gained powder mixing, stir evenly, both treatment reflux esophagitis decoction of the present invention.
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Application publication date: 20150916 |