CN104958636A - Medicinal composition for treating functional dyspepsia and preparation method of medicinal composition - Google Patents

Abstract

The invention discloses a medicinal composition for treating functional dyspepsia and a preparation method of the medicinal composition, and belongs to the technical field of traditional Chinese medicines. The medicinal composition is prepared from the following raw materials in parts by weight: 9-30 parts of codonopsis pilosula, 5-20 parts of cuttle bone, 5-25 parts of Chinese yam, 6-30 parts of astragalus membranaceus, 9-15 parts of poria cocos, 6-12 parts of atractylodes macrocephala, 3-10 parts of dried tangerine or orange peel, 1-10 parts of rosa banksiae, 6-15 parts of cherry leaves, 9-15 parts of malt, 9-12 parts of hawthorn, 3-9 parts of radix bupleuri, 3-9 parts of mangnolia officinalis and 1-10 parts of liquorice. The medicinal composition has the effects of smoothing qi and helping digestion as well as tonifying the spleen and promoting appetite, and also has the advantages of simple preparation process, security and effectiveness, small side effect, convenience to take, easiness in popularization and application, and the like.

Description

A kind of pharmaceutical composition for the treatment of functional dyspepsia and preparation method thereof

Technical field

The invention belongs to technical field of Chinese medicines, relate to a kind of pharmaceutical composition for the treatment of functional dyspepsia and preparation method thereof.

Background technology

Functional dyspepsia, also known as dyspepsia, refers to have the malaise symptoms such as upper abdominal pain, big belly, early full, belch, inappetence, Nausea and vomiting, gets rid of the one group of clinical syndrome causing the organic disease of above-mentioned symptom on inspection.Sustainable or the recurrent exerbation of symptom, accumulative more than 12 weeks in course of disease December more than month or in the past.Functional dyspepsia is modal a kind of functional gastrointestinal disorder clinically.Affect the daily life factor that gastrointestinal function brings out functional dyspepsia symptom and generally include three aspects: one is the distress of psychology and spirit; Two is Bad Eating Habit, comprise irritable food (coffee, strong tea, sweet food, greasy, raw and cold etc.) and Bad Eating Habit (comprise on an empty stomach, frequent edible irritable food, and irregular feed or gluttony crapulence etc.); Three is impacts of ambient temperature.

For functional dyspepsia, the predicament that western medicine faces is: 1. pathogenesis is illustrated not yet completely: the many factors such as sensitivity, inflammation, HP infection that may relate to dyskinesis, internal organs, so think that functional dyspepsia is that the gastrointestinal motility disorder that multiple physiology and social factor participate in is diseases related.2. lack the treatment of specially good effect, the state of an illness easily repeatedly, at substantial medical resource.At present, western medical treatment without specific drug, mainly experiential therapy, the medicine of such as gastric acid secretion inhibiting, short digestive tract power reinforcing medicine (domperidone, itopride etc.) and Helicobacter pylori eradication for treatment.Modern Chinese medicine research is thought that primary disease is many and is not relaxed because of feelings will, eating and drinking without temperance, overstrain, affection of exogenous damp etc. are multifactor wherein not to relax the most common with feelings will especially, and cause depression of liver-QI the liver failing to maintain the normal flow of QI, stagnation of liver-QI takes advantage of spleen, hyperactive liver-QI attacking the stomach makes dysfunction of the spleen in transportation, and taste ascending or descending movement of vital Qi is not normal, caused by middle burnt painful abdominal mass plug is obstructed.

Chinese patent application 201410645308.1 discloses a kind of Chinese medicine being used for the treatment of functional dyspepsia, and this Chinese medicine is prepared from by the raw material of following weight portion: Rhizoma Sparganii 7 parts, Rhizoma Curcumae 3 parts, Engelhardtia roxburghiana skin 9 parts, tumor hair Herba Swertiae bimaculatae 5 parts, Cortex Magnoliae Officinalis 6 parts, Radix Crepidis elongatae 14 parts and 15 parts, Fructus Hordei Germinatus.

Summary of the invention

The invention provides a kind of pharmaceutical composition for the treatment of functional dyspepsia, this pharmaceutical composition has effect of promote qi circulation digestion promoting and spleen benefiting and stimulating the appetite, also have that preparation technology is simple, safe and effective, side effect is low, taking convenience and be easy to advantages such as applying, in addition, the present invention also provides corresponding manufacturing process to be made and facilitate easy-to-use preparation under the prerequisite ensureing curative effect by this pharmaceutical composition.

Pharmaceutical composition of the present invention is prepared from by the raw material of following weight portion: Radix Codonopsis 9-30 part, Os Sepiae 5-20 part, Rhizoma Dioscoreae 5-25 part, Radix Astragali 6-30 part, Poria 9-15 part, Rhizoma Atractylodis Macrocephalae 6-12 part, Pericarpium Citri Reticulatae 3-10 part, Radix Aucklandiae 1-10 part, Folium Pruni pseudocerasi 6-15 part, Fructus Hordei Germinatus 9-15 part, Fructus Crataegi 9-12 part, Radix Bupleuri 3-9 part, Cortex Magnoliae Officinalis 3-9 part and Radix Glycyrrhizae 1-10 part.

Further, described pharmaceutical composition is prepared from by the raw material of following weight portion: Radix Codonopsis 9 parts, Os Sepiae 5 parts, Rhizoma Dioscoreae 5 parts, the Radix Astragali 6 parts, 9 parts, Poria, the Rhizoma Atractylodis Macrocephalae 6 parts, Pericarpium Citri Reticulatae 3 parts, the Radix Aucklandiae 1 part, Folium Pruni pseudocerasi 6 parts, 9 parts, Fructus Hordei Germinatus, Fructus Crataegi 9 parts, Radix Bupleuri 3 parts, Cortex Magnoliae Officinalis 3 parts and 1 part, Radix Glycyrrhizae.

Further, described pharmaceutical composition is prepared from by the raw material of following weight portion: Radix Codonopsis 30 parts, Os Sepiae 20 parts, Rhizoma Dioscoreae 25 parts, the Radix Astragali 30 parts, 15 parts, Poria, the Rhizoma Atractylodis Macrocephalae 12 parts, Pericarpium Citri Reticulatae 10 parts, the Radix Aucklandiae 10 parts, Folium Pruni pseudocerasi 15 parts, 15 parts, Fructus Hordei Germinatus, Fructus Crataegi 12 parts, Radix Bupleuri 9 parts, Cortex Magnoliae Officinalis 9 parts and 10 parts, Radix Glycyrrhizae.

Further, described pharmaceutical composition is prepared from by the raw material of following weight portion: Radix Codonopsis 20 parts, Os Sepiae 13 parts, Rhizoma Dioscoreae 15 parts, the Radix Astragali 18 parts, 12 parts, Poria, the Rhizoma Atractylodis Macrocephalae 9 parts, Pericarpium Citri Reticulatae 6 parts, the Radix Aucklandiae 5 parts, Folium Pruni pseudocerasi 10 parts, 12 parts, Fructus Hordei Germinatus, Fructus Crataegi 10 parts, Radix Bupleuri 6 parts, Cortex Magnoliae Officinalis 6 parts and 5 parts, Radix Glycyrrhizae.

Further, described pharmaceutical composition is made into capsule, granule, tablet, powder, decoction or drop pill.

Accordingly, the preparation method of described pharmaceutical composition comprises following step:

1) by Fructus Hordei Germinatus, Fructus Crataegi, Pericarpium Citri Reticulatae and Radix Glycyrrhizae decontamination, clean, dry, grind to form 100-200 order fine powder;

2) Folium Pruni pseudocerasi is mashed, get its juice, for subsequent use;

3) Radix Codonopsis, Rhizoma Dioscoreae, the Radix Astragali, Os Sepiae, Poria, the Rhizoma Atractylodis Macrocephalae, the Radix Aucklandiae, Radix Bupleuri magnolia obovata are cleaned, dry, be ground into coarse powder;

4) by step 3) coarse powder prepared, add coarse powder 4-8 times amount water soaking 1-3 hour, intense fire decocts 30-60 minute, then uses slow fire boiling 1-3 hour, filter, filtering residue adds 2-4 times of water gaging, and intense fire decocts boiling 15-30 minute, then uses slow fire boiling 1-2 hour, filter, merge twice filtrate, under 60-75 DEG C of environment, filtrate is concentrated into the dope that relative density is 1.10-1.20, for subsequent use;

5) by above-mentioned steps 2) juice prepared and step 4) dope made merges, is concentrated into the thick paste that relative density is 1.30-1.35, drying under reduced pressure, crosses 100-200 mesh sieve, obtain uniform fine powder after pulverizing under 55-70 DEG C of environment;

6) by step 1) and step 5) make fine powder mixing, stir, obtain pharmaceutical composition of the present invention.

Source, the nature and flavor of the present invention's component used, return through and effect:

Radix Codonopsis: this product is the dry root of Campanulaceae Radix Codonopsis; Sweet in the mouth, property is put down; Return spleen, lung meridian; Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.

Os Sepiae: this product is the inner shell of Sepiidae animal sepiellae seu sepiae; Salty in the mouth, puckery, warm in nature; Return liver, kidney channel; Astringing to arrest bleeding, treating spontaneous emission and leukorrhagia, relieving gastric hyperacidity to alleviate stomachache, removing dampness sore.

Rhizoma Dioscoreae: this product is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae; Sweet in the mouth, property is put down; Return spleen, lung, kidney channel; Spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.

The Radix Astragali: this product is the root of the leguminous plant Radix Astragali; Sweet in the mouth, tepor; Return lung, spleen, liver, kidney channel; Invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, diuresis, granulation promoting.

Poria: this product is the dry sclerotia of On Polyporaceae Poria; Sweet in the mouth, light, property is put down; GUIXIN, lung, spleen, kidney channel; Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.

The Rhizoma Atractylodis Macrocephalae: this product is the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae; Bitter in the mouth, sweet, warm in nature; Return spleen, stomach warp; Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.

Pericarpium Citri Reticulatae: be the dry mature skin of rutaceae orange and variety thereof; Bitter in the mouth, pungent, warm in nature; Return lung, spleen channel; Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.

The Radix Aucklandiae: this product is the dry root of the feverfew Radix Aucklandiae; Acrid in the mouth, hardship, warm in nature; Return spleen, stomach, large intestine, three burnt, gallbladder meridians; Promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.

Folium Pruni pseudocerasi: this product is the blade of rosaceous plant Fructus Pruni pseudocerasi; Sweet in the mouth, hardship, warm in nature; Return liver, spleen, lung meridian; Warming middle-JIAO and strengthening the spleen, cough-relieving is stopped blooding, removing toxic substances parasite killing.

Fructus Hordei Germinatus: this product is that the mature fruit of grass Fructus Hordei Vulgaris obtains through drying of germinateing; Sweet in the mouth, property is put down; Return spleen, stomach warp; Promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, moves back newborn relieving distension.

Fructus Crataegi: this product is the dry mature fruit of rosaceous plant Fructus Pyri Pashiae or Fructus Crataegi; Sour in the mouth, sweet, slightly warm in nature; Return spleen, stomach, Liver Channel; Promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.

Radix Bupleuri: this product is the dry root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii.; Bitter in the mouth, cold nature; Return liver, gallbladder meridian; Reconciling superficies and interior, soothing the liver, yang invigorating.

Cortex Magnoliae Officinalis: this product is the dry dried bark of Magnoliacea plant Cortex Magnoliae Officinalis or magnolia officinalis rehd.et wils.var.biloba rehd.et wils., root bark and branch skin; Bitter in the mouth, pungent, warm in nature; Return spleen, stomach, lung, large intestine channel; Dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full.

Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.

Compared with prior art, pharmaceutical composition of the present invention has following technical advantage:

1, pharmaceutical composition of the present invention is by the synergism between each component, and the remarkable efficacy had in treatment functional dyspepsia, especially has effect of promote qi circulation digestion promoting and spleen benefiting and stimulating the appetite.

2, compared with the chemotherapeutic agent of Current therapeutic functional dyspepsia, pharmaceutical composition of the present invention is natural pure Chinese medicinal preparation, untoward reaction and side effect significantly reduce, and pharmaceutical composition effect of the present invention is comprehensive, medication effect is better, efficiently solve the morbidity root of functional dyspepsia, and improve the quality of life of patient.

3, pharmaceutical composition of the present invention also has compatibility science, preparation technology is simple, safe and effective, side effect is low, taking convenience and be easy to advantages such as applying.

Detailed description of the invention

It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.

embodiment 1:the medicinal granule of preparation treatment functional dyspepsia

Embodiment 1 pharmaceutical composition is prepared from by the raw material of following parts by weight: Radix Codonopsis 9 parts, Os Sepiae 5 parts, Rhizoma Dioscoreae 5 parts, the Radix Astragali 6 parts, 9 parts, Poria, the Rhizoma Atractylodis Macrocephalae 6 parts, Pericarpium Citri Reticulatae 3 parts, the Radix Aucklandiae 1 part, Folium Pruni pseudocerasi 6 parts, 9 parts, Fructus Hordei Germinatus, Fructus Crataegi 9 parts, Radix Bupleuri 3 parts, Cortex Magnoliae Officinalis 3 parts and 1 part, Radix Glycyrrhizae.

Preparation method is as follows:

1) by Fructus Hordei Germinatus, Fructus Crataegi, Pericarpium Citri Reticulatae and Radix Glycyrrhizae decontamination, clean, dry, grind to form 100 order fine powders;

2) Folium Pruni pseudocerasi is mashed, get its juice, for subsequent use;

3) Radix Codonopsis, Rhizoma Dioscoreae, the Radix Astragali, Os Sepiae, Poria, the Rhizoma Atractylodis Macrocephalae, the Radix Aucklandiae, Radix Bupleuri magnolia obovata are cleaned, dry, be ground into coarse powder;

4) by step 3) coarse powder prepared, add coarse powder 4 times amount water soaking 3 hours, intense fire decocts 30 minutes, then uses slow fire boiling 2 hours, filter, filtering residue adds 3 times of water gagings, and intense fire decocts boiling 15 minutes, then uses slow fire boiling 1 hour, filter, merge twice filtrate, under 60 DEG C of environment, filtrate is concentrated into the dope that relative density is 1.10, for subsequent use;

5) by above-mentioned steps 2) juice prepared and step 4) dope made merges, is concentrated into the thick paste that relative density is 1.30, drying under reduced pressure, crosses 100 mesh sieves, obtain uniform fine powder after pulverizing under 60 DEG C of environment;

6) by step 1) and step 5) make fine powder mixing, stir, add adjuvant, adjuvant is filler Icing Sugar and wetting agent distilled water, fine powder and filler, the amount ratio of wetting agent is 1:1:1, obtain soft material processed, the standard of this soft material processed should be that hands is pinched agglomerating, namely light pressure falls apart, soft material processed is put into rotary extrusion type granulator, obtain wet granular, dry under 60 DEG C of conditions, obtain dry granule, cross No. one and screen out big particle, make uniform particles, carry out quality inspection, through after the assay was approved, pack, obtain the granule of the embodiment of the present invention 1 pharmaceutical composition.

embodiment 2:the medicinal granule of preparation treatment functional dyspepsia

Embodiment 2 pharmaceutical composition is prepared from by the raw material of following parts by weight: Radix Codonopsis 30 parts, Os Sepiae 20 parts, Rhizoma Dioscoreae 25 parts, the Radix Astragali 30 parts, 15 parts, Poria, the Rhizoma Atractylodis Macrocephalae 12 parts, Pericarpium Citri Reticulatae 10 parts, the Radix Aucklandiae 10 parts, Folium Pruni pseudocerasi 15 parts, 15 parts, Fructus Hordei Germinatus, Fructus Crataegi 12 parts, Radix Bupleuri 9 parts, Cortex Magnoliae Officinalis 9 parts and 10 parts, Radix Glycyrrhizae.

Preparation method is with embodiment 1.

embodiment 3:the medicinal granule of preparation treatment functional dyspepsia

Embodiment 3 pharmaceutical composition is prepared from by the raw material of following parts by weight: Radix Codonopsis 20 parts, Os Sepiae 13 parts, Rhizoma Dioscoreae 15 parts, the Radix Astragali 18 parts, 12 parts, Poria, the Rhizoma Atractylodis Macrocephalae 9 parts, Pericarpium Citri Reticulatae 6 parts, the Radix Aucklandiae 5 parts, Folium Pruni pseudocerasi 10 parts, 12 parts, Fructus Hordei Germinatus, Fructus Crataegi 10 parts, Radix Bupleuri 6 parts, Cortex Magnoliae Officinalis 6 parts and 5 parts, Radix Glycyrrhizae.

Preparation method is with embodiment 1.

embodiment 4:the medicament dropping pill of preparation treatment functional dyspepsia

Embodiment 4 pharmaceutical composition is prepared from by the raw material of following parts by weight: Radix Codonopsis 9 parts, Os Sepiae 5 parts, Rhizoma Dioscoreae 5 parts, the Radix Astragali 6 parts, 9 parts, Poria, the Rhizoma Atractylodis Macrocephalae 6 parts, Pericarpium Citri Reticulatae 3 parts, the Radix Aucklandiae 1 part, Folium Pruni pseudocerasi 6 parts, 9 parts, Fructus Hordei Germinatus, Fructus Crataegi 9 parts, Radix Bupleuri 3 parts, Cortex Magnoliae Officinalis 3 parts and 1 part, Radix Glycyrrhizae.

Preparation method is as follows:

1) by Fructus Hordei Germinatus, Fructus Crataegi, Pericarpium Citri Reticulatae and Radix Glycyrrhizae decontamination, clean, dry, grind to form 200 order fine powders;

2) Folium Pruni pseudocerasi is mashed, get its juice, for subsequent use;

3) Radix Codonopsis, Rhizoma Dioscoreae, the Radix Astragali, Os Sepiae, Poria, the Rhizoma Atractylodis Macrocephalae, the Radix Aucklandiae, Radix Bupleuri magnolia obovata are cleaned, dry, be ground into coarse powder;

4) by step 3) coarse powder prepared, add coarse powder 6 times amount water soaking 2 hours, intense fire decocts 60 minutes, then uses slow fire boiling 1 hour, filter, filtering residue adds 4 times of water gagings, and intense fire decocts boiling 30 minutes, then uses slow fire boiling 1 hour, filter, merge twice filtrate, under 70 DEG C of environment, filtrate is concentrated into the dope that relative density is 1.20, for subsequent use;

5) by above-mentioned steps 2) juice prepared and step 4) dope made merges, is concentrated into the thick paste that relative density is 1.35, drying under reduced pressure, crosses 200 mesh sieves, obtain uniform fine powder after pulverizing under 65 DEG C of environment;

6) by step 1) and step 5) make fine powder mixing, stir, then the water-soluble base polyethylene glycol 6000 of fine powder weight 8 times is added, mix homogeneously, heating, emulsifying obtains medicinal liquid, put into pill dripping machine and make dripping, add the condensed fluid liquid paraffin of fine powder weight 1/8, obtained pellet, wherein, condensed fluid and substrate are not miscible, after drop pill molding, removing liquid paraffin, and dry arrangement, carry out quality inspection, after qualified on inspection, packaging, obtains the drop pill of the embodiment of the present invention 4 Chinese medicine composition.

embodiment 5:the medicament dropping pill of preparation treatment functional dyspepsia

The embodiment of the present invention 5 pharmaceutical composition is prepared from by the raw material of following parts by weight: Radix Codonopsis 30 parts, Os Sepiae 20 parts, Rhizoma Dioscoreae 25 parts, the Radix Astragali 30 parts, 15 parts, Poria, the Rhizoma Atractylodis Macrocephalae 12 parts, Pericarpium Citri Reticulatae 10 parts, the Radix Aucklandiae 10 parts, Folium Pruni pseudocerasi 15 parts, 15 parts, Fructus Hordei Germinatus, Fructus Crataegi 12 parts, Radix Bupleuri 9 parts, Cortex Magnoliae Officinalis 9 parts and 10 parts, Radix Glycyrrhizae.

Preparation method is with embodiment 4.

embodiment 6:the medicament dropping pill of preparation treatment functional dyspepsia

The embodiment of the present invention 6 pharmaceutical composition is prepared from by the raw material of following parts by weight: Radix Codonopsis 20 parts, Os Sepiae 13 parts, Rhizoma Dioscoreae 15 parts, the Radix Astragali 18 parts, 12 parts, Poria, the Rhizoma Atractylodis Macrocephalae 9 parts, Pericarpium Citri Reticulatae 6 parts, the Radix Aucklandiae 5 parts, Folium Pruni pseudocerasi 10 parts, 12 parts, Fructus Hordei Germinatus, Fructus Crataegi 10 parts, Radix Bupleuri 6 parts, Cortex Magnoliae Officinalis 6 parts and 5 parts, Radix Glycyrrhizae.

Preparation method is with embodiment 4.

clinical observation on the therapeutic effect

1, case selection: in 600 routine functional dyspepsia clinical volunteers patients, age bracket is 18-69 year, and all patients all has typical functional dyspepsia symptom.

2, diagnostic criteria:

(1) Western medicine diagnose standard: the Rome III diagnostic criteria meeting functional gastrointestinal disorder: functional dyspepsia must comprise: 1. following 1 or many: a, post-prandial fullness is uncomfortable; B, early full sense; C, upper abdominal pain; D, upper abdomen burn feeling; And there is no the evidence of the organic disease can explaining above-mentioned symptom 2..Before diagnosis, symptom occurs at least 6 months, within nearly 3 months, meets above standard.

(2) tcm diagnosis standard: with reference to " new Chinese medicine treats dyspeptic guideline of clinical investigations " syndrome of incoordination between liver and stomach in " combination of Chinese and Western medicine diagnosis and treatment project of functional dyspepsia " hyperactive liver-QI attacking the stomach card and 2002 " new Chinese medicine guideline of clinical investigations ": primary symptom: gastral cavilty distension, pain, sighing frequently, loss of appetite, often increase the weight of because of emotional factors, pale tongue with white fur, stringy pulse; Secondary disease: early full, belch pantothenic acid, heartburn, tending to vomit of feeling sick, irritable.

3, Excluded cases standard:

(1) do not meet inclusive criteria, or participate in the patient of other drug clinical experiment;

(2) merge gastric organic disease, as peptic ulcer is shown in gastroscopy, rotten to the corn and hemorrhage etc., pathologic finding finds gastric mucosa atrophy person;

(3) gastroesophageal reflux disease, irritable bowel syndrome etc. is merged;

(4) gestation or women breast-feeding their children, allergic constitution and to this medicine allergy sufferers;

(5) the severe primary disease patients such as cardiovascular and cerebrovascular vessel, liver, kidney and blood system are merged;

(6) patient such as psychosis, senile dementia.

4, efficacy assessment standard:

(1) fully recover: clinical symptoms, sign disappear or substantially disappear;

(2) effective: clinical symptoms, sign are obviously improved;

(3) effective: clinical symptoms, sign all take a favorable turn;

(4) invalid: clinical syndrome, sign are all not improved, even increase the weight of;

(5) total effective rate=(recovery from illness+effective+effectively)/total number of cases * 100%.

5, instructions of taking: 600 patients are divided into 6 groups at random, often organize 100 people, be respectively treatment A group, treatment B group, treatment C group, treatment D group, treatment E group and matched group, treatment A group takes the granule that the embodiment of the present invention 1 prepares, every day 3 times, each 2g, treatment B group takes the granule that the embodiment of the present invention 2 prepares, every day 3 times, each 2g, treatment C group takes the granule that the embodiment of the present invention 3 prepares, every day 3 times, each 2g, treatment D group takes the drop pill (0.1g* ball/bottle) that the embodiment of the present invention 4 prepares, every day 3 times, each 6 balls, treatment E group takes the drop pill (0.1g* ball/bottle) that the embodiment of the present invention 5 prepares, every day 3 times, each 6 balls, matched group takes the domperidone tablet of commercial type, one time 1, 3 times on the one, take one month respectively.

6, points for attention: period in a medicine is avoided and eaten raw food, greasy, fish raw meat and maror, can stop using after pregnancy.In addition, due to conditions of patients weight and course of disease length difference, also there is individual variation to drug susceptibility, patient can according to the situation drug administration of oneself.

7, therapeutic outcome:

Table 1 therapeutic outcome

This experiment contrast group domperidone tablet Main Ingredients and Appearance is domperidone 10 milligrams, and minor subject is starch, hydrogenated vegetable oil, lactose hydrous, magnesium stearate, microcrystalline Cellulose, polyvinylpyrrolidone, pregelatinized Starch, sodium lauryl sulphate; Cure mainly functional dyspepsia, gastroesophageal reflux disease, reflux esophagitis, gastritis.As shown in Table 1, the cure rate of pharmaceutical composition of the present invention reaches 75.0%, total effective rate reaches 85.0%, higher than cure rate and the total effective rate of matched group, wherein best with the therapeutic effect for the treatment of C group, visible, the good effect of pharmaceutical composition of the present invention, cure rate is high, can be used as the drug use for the treatment of functional dyspepsia.

Claims (6)

1. treat a pharmaceutical composition for functional dyspepsia, it is characterized in that being made up of the raw material of following weight portion: Radix Codonopsis 9-30 part, Os Sepiae 5-20 part, Rhizoma Dioscoreae 5-25 part, Radix Astragali 6-30 part, Poria 9-15 part, Rhizoma Atractylodis Macrocephalae 6-12 part, Pericarpium Citri Reticulatae 3-10 part, Radix Aucklandiae 1-10 part, Folium Pruni pseudocerasi 6-15 part, Fructus Hordei Germinatus 9-15 part, Fructus Crataegi 9-12 part, Radix Bupleuri 3-9 part, Cortex Magnoliae Officinalis 3-9 part and Radix Glycyrrhizae 1-10 part.

2. the pharmaceutical composition for the treatment of functional dyspepsia as claimed in claim 1, is characterized in that being made up of the raw material of following weight portion: Radix Codonopsis 9 parts, Os Sepiae 5 parts, Rhizoma Dioscoreae 5 parts, the Radix Astragali 6 parts, 9 parts, Poria, the Rhizoma Atractylodis Macrocephalae 6 parts, Pericarpium Citri Reticulatae 3 parts, the Radix Aucklandiae 1 part, Folium Pruni pseudocerasi 6 parts, 9 parts, Fructus Hordei Germinatus, Fructus Crataegi 9 parts, Radix Bupleuri 3 parts, Cortex Magnoliae Officinalis 3 parts and 1 part, Radix Glycyrrhizae.

3. the pharmaceutical composition for the treatment of functional dyspepsia as claimed in claim 1, is characterized in that being made up of the raw material of following weight portion: Radix Codonopsis 30 parts, Os Sepiae 20 parts, Rhizoma Dioscoreae 25 parts, the Radix Astragali 30 parts, 15 parts, Poria, the Rhizoma Atractylodis Macrocephalae 12 parts, Pericarpium Citri Reticulatae 10 parts, the Radix Aucklandiae 10 parts, Folium Pruni pseudocerasi 15 parts, 15 parts, Fructus Hordei Germinatus, Fructus Crataegi 12 parts, Radix Bupleuri 9 parts, Cortex Magnoliae Officinalis 9 parts and 10 parts, Radix Glycyrrhizae.

4. the pharmaceutical composition for the treatment of functional dyspepsia as claimed in claim 1, is characterized in that being made up of the raw material of following weight portion: Radix Codonopsis 20 parts, Os Sepiae 13 parts, Rhizoma Dioscoreae 15 parts, the Radix Astragali 18 parts, 12 parts, Poria, the Rhizoma Atractylodis Macrocephalae 9 parts, Pericarpium Citri Reticulatae 6 parts, the Radix Aucklandiae 5 parts, Folium Pruni pseudocerasi 10 parts, 12 parts, Fructus Hordei Germinatus, Fructus Crataegi 10 parts, Radix Bupleuri 6 parts, Cortex Magnoliae Officinalis 6 parts and 5 parts, Radix Glycyrrhizae.

5. the pharmaceutical composition for the treatment of functional dyspepsia as claimed in claim 1, is characterized in that: described pharmaceutical composition can be made into capsule, granule, tablet, powder, decoction or drop pill.

6. prepare as arbitrary in claim 1-4 as described in the method for pharmaceutical composition for the treatment of functional dyspepsia, it is characterized in that comprising the steps:

1) Fructus Hordei Germinatus, Fructus Crataegi, Pericarpium Citri Reticulatae and Radix Glycyrrhizae are cleaned, dry, grind to form 100-200 order fine powder;

2) Folium Pruni pseudocerasi is mashed, get its juice, for subsequent use;

3) Radix Codonopsis, Rhizoma Dioscoreae, the Radix Astragali, Os Sepiae, Poria, the Rhizoma Atractylodis Macrocephalae, the Radix Aucklandiae, Radix Bupleuri magnolia obovata are cleaned, dry, be ground into coarse powder;

4) by step 3) coarse powder prepared, add coarse powder 4-8 times amount water soaking 1-3 hour, intense fire decocts 30-60 minute, then uses slow fire boiling 1-3 hour, filter, filtering residue adds 2-4 times of water gaging, and intense fire decocts boiling 15-30 minute, then uses slow fire boiling 1-2 hour, filter, merge twice filtrate, under 60-75 DEG C of environment, filtrate is concentrated into the dope that relative density is 1.10-1.20, for subsequent use;

5) by above-mentioned steps 2) juice prepared and step 4) dope made merges, is concentrated into the thick paste that relative density is 1.30-1.35, drying under reduced pressure, crosses 100-200 mesh sieve, obtain uniform fine powder after pulverizing under 55-70 DEG C of environment;

6) by step 1) and step 5) make fine powder mixing, stir, obtain described pharmaceutical composition.