CN104971215A - Traditional Chinese medicine composition for treating spleen-deficiency gastrasthenia type chronic gastritis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating spleen-deficiency gastrasthenia type chronic gastritis and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicines and relates to a traditional Chinese medicine composition for treating spleen-deficiency gastrasthenia type chronic gastritis and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials: milkvetch root, codonopsis pilosula, dwarf lilyturf tuber powder, Chinese magnoliavine fruit, pinellia tuber, desertliving cistanche, dark plum fruit, largehead atractylodes rhizome, immature bitter orange, officinal magnolia bark, flos caryophyllata, rhizoma corydalis, Szechwan chinaberry fruit and licorice root. The traditional Chinese medicine composition has the effects of warming and nourishing stomach, promoting qi circulation to relieve pain, maintaining vital qi, eliminating dampness to lower the adverse flow of qi, promoting qi circulation to remove stagnation of qi, strengthening spleen and tonifying kidney, as well as dispelling wind and heat from the body, and also has the advantages of simple preparation process, strong pertinence, low side effects, convenience in taking and easiness in popularization and application.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to and a kind ofly treat Chinese medicine composition of insufficiency of the spleen stomach weak type chronic gastritis and preparation method thereof.
Background technology
Chronic gastritis refers to the various chronic gastric Mucosal inflammatory pathological changes that different pathogeny causes, and be a kind of commonly encountered diseases, its sickness rate ranks first in various gastropathy.Chronic gastritis lacks specific symptom, and the weight of symptom and the lesion degree of gastric mucosa are also non-uniform.Most patient often asymptomatic or have degree different indigestion symptom as upper abdomen dull pain, loss of appetite, post-prandial fullness, acid regurgitation etc.Chronic Atrophic Gastritis Patients can have anemia, becomes thin, glossitis, diarrhoea etc., and person's upper abdominal pain that individuals patients accompanies mucosal erosion is comparatively obvious, and can have hemorrhage, as hematemesis, melena.Symptom is recurrent exerbation usually, and irregularities is suffered from abdominal pain, and pain often to come across in feeding process or after the meal, and majority is positioned at epigastrium, umbilicus week, some patients position are not fixed, and the intermittent dull pain of the lighter or dull pain, severe patient are violent angor.
Chinese medicine has treating both the principal and secondary aspects of a disease in treatment chronic gastritis, curative effect gentleness, the advantage not easily recurred.Gastritis can be divided into four classes in the traditional Chinese medical science, is respectively: hepatogastric vital energy stagnation type, deficiency of the spleen and heat of the stomach type, due to weakness of spleen and stomach, type of deficiency of stomach yin.The cause of disease of gastritis is more complicated, and its sick position is all below gastral cavilty, begins then relevant with taste, then undermines liver, kidney.Its pathogenesis is many by emptiness of spleen and stomach, and inside and outside heresy is taken advantage of and attacks it, makes the clear YANG failing to ascend of spleen, caused by the turbid YIN failing to descend of stomach.Various paathogenic factor often cross correlation, pathogenesis have deficiency and excess point, beginnings from the beginning of based on excess pathogen, diseases caused by exogenous pathogenic factor six climate exopathogens, the pent-up of feelings will, or because of food, gas, expectorant, wet, caused by heat, prolonged illness is then based on void, or deficiency and excess is held concurrently mutually, coldheat complex.Insufficiency of the spleen stomach weak type gastritis is the common type of chronic gastritis, main syndromes is shown in that the happiness of vague epigastralgia, pain relieved by pressing is warm, distension after food, vomit clear saliva, decreased food intake of receiving is few, diarrhoea loose stool, extremity are aching and limp, aversion to cold and preference for warmth, lustreless complexion, body of the tongue are light red, white and thin fur, thready and weak pulse or heavy thin, for middle void has cold, levying of hypoactivity of spleen-YANG.The traditional Chinese medical science stresses determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, for dissimilar gastritis, should suit the remedy to the case, and rational compatibility of drugs just can play the effect shortened the course of disease, cure completely.
Chinese patent application 201410771775.9 discloses a kind of Chinese medicine for the treatment of insufficiency of the spleen stomach weak type chronic gastritis, and this Chinese medicine is made up of the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Dioscoreae, Semen Coicis, Cortex Magnoliae Officinalis, Rhizoma Alpiniae Officinarum, Fructus Jujubae, Radix Angelicae Sinensis, Radix Ginseng and Radix Glycyrrhizae.This Chinese medicine is with strong points, soon effective, but this Chinese medicine effect in promoting the circulation of QI to relieve pain is not very remarkable.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition for the treatment of insufficiency of the spleen stomach weak type chronic gastritis, this Chinese medicine composition has effect of stomach warming nourishing the stomach, promoting the circulation of QI to relieve pain, reinforcing body resistance, damp eliminating sending down the abnormal ascending QI, circulation of qi promoting removing food stagnancy and tonifying speen and tonifying kidney, dispelling wind and heat pathogens, also have that preparation technology is simple, with strong points, side effect is low, taking convenience and be easy to advantages such as applying, in addition, the present invention also provides corresponding manufacturing process to be made and facilitate easy-to-use preparation under the prerequisite ensureing curative effect by this pharmaceutical composition.
Chinese medicine composition of the present invention is prepared from by the raw material of following parts by weight:
Radix Astragali 3-15 part, Radix Codonopsis 6-15 part, Radix Ophiopogonis 3-10 part, Fructus Schisandrae Chinensis 1-9 part, Rhizoma Pinelliae 3-9 part, Herba Cistanches 3-9 part, Fructus Mume 6-12 part, Rhizoma Atractylodis Macrocephalae 6-12 part, Fructus Aurantii Immaturus 3-9 part, Cortex Magnoliae Officinalis 3-9 part, Flos Caryophylli 1-3 part, Rhizoma Corydalis 3-15 part, Fructus Toosendan 3-10 part and Radix Glycyrrhizae 1-10 part.
Further, described Chinese medicine composition is prepared from by the raw material of following parts by weight: the Radix Astragali 3 parts, Radix Codonopsis 6-part, Radix Ophiopogonis 3 parts, Fructus Schisandrae Chinensis 1 part, the Rhizoma Pinelliae 3 parts, Herba Cistanches 3 parts, Fructus Mume 6 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, Fructus Aurantii Immaturus 3 parts, Cortex Magnoliae Officinalis 3 parts, Flos Caryophylli 1 part, Rhizoma Corydalis 3 parts, Fructus Toosendan 3 parts and 1 part, Radix Glycyrrhizae.
Further, described Chinese medicine composition is prepared from by the raw material of following parts by weight: the Radix Astragali 15 parts, Radix Codonopsis 15 parts, Radix Ophiopogonis 10 parts, Fructus Schisandrae Chinensis 9 parts, the Rhizoma Pinelliae 9 parts, Herba Cistanches 9 parts, Fructus Mume 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Fructus Aurantii Immaturus 9 parts, Cortex Magnoliae Officinalis 9 parts, Flos Caryophylli 3 parts, Rhizoma Corydalis 15 parts, Fructus Toosendan 10 parts, 10 parts, Radix Glycyrrhizae.
Further, described Chinese medicine composition is prepared from by the raw material of following parts by weight: the Radix Astragali 10 parts, Radix Codonopsis 10 parts, Radix Ophiopogonis 6 parts, Fructus Schisandrae Chinensis 5 parts, the Rhizoma Pinelliae 6 parts, Herba Cistanches 6 parts, Fructus Mume 9 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, Fructus Aurantii Immaturus 6 parts, Cortex Magnoliae Officinalis 6 parts, Flos Caryophylli 2 parts, Rhizoma Corydalis 9 parts, Fructus Toosendan 6 parts, 5 parts, Radix Glycyrrhizae.
Further, described Chinese medicine composition is oral formulations.
Again further, described oral formulations is tablet, capsule, drop pill, granule, powder or oral liquid.
Accordingly, the preparation method of described Chinese medicine composition comprises following step:
Take the Radix Astragali, Radix Codonopsis, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Rhizoma Pinelliae, Herba Cistanches, Fructus Mume, the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Flos Caryophylli, Rhizoma Corydalis, Fructus Toosendan and Radix Glycyrrhizae, add the water of initial feed 8-12 times of weight, soak 12-24 hour, backflow decocts 1-3 hour, filter, add the water of initial feed 3-6 times of weight again, backflow decocts 1-3 hour, filter, obtain filtrate, merging filtrate, the Chinese medical concrete that relative density is 1.25-1.35 is concentrated under 50 DEG C of-60 DEG C of conditions, dry, be ground into fine powder, obtain Chinese medicine composition of the present invention, add adjuvant, clinical required preparation is prepared into by modern medicines preparation method.
The Chinese crude drug Radix Astragali is the root of leguminous herbaceous plant's Radix Astagali, Radix Astragali, has the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.Modern medicine study shows, the Radix Astragali has enhancing human body immunity function, protects the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.Jishengshenqiwan albuminuria can be eliminated, strengthen myocardial contraction, regulate blood sugar content.The Radix Astragali can not only coronary artery dilator, improves blood supply of cardiac muscle, improves immunologic function, and can the process of delaying cell aging.Radix Astragali instant, can decoct soup, soft extracts, infusing drugs in wine, enter dish etc.
Radix Codonopsis sweet in the mouth, property is put down, and has invigorating the spleen and replenishing QI, quenches the thirst, effect of spleen invigorating lung benefiting, nourishing blood to promote the production of body fluid.For deficiency of both the splenic and pulmonary QI, lack of appetite asthenia, cough dyspnea due to deficiency, insufficiency of vital energy and blood, shallow complexion, shortness of breath and palpitation, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, and lazy speech is losed heart, and myasthenia of limbs, is off one's feed, the deficiency of vital energy, and gas Tianjin two is empty, and QI and blood is two loses and the disease such as blood deficiency and yellow complexion.
Radix Ophiopogonis is the tuber of liliaceous plant Radix Ophiopogonis, Hubei Radix Ophiopogonis, short Roripa mountain wheat or Radix Liriopes, dwarf lilyturf etc.Sweet, micro-hardship, is slightly cold.GUIXIN, lung, stomach warp.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, chronic consumptive disease is coughed, and Tianjin wound is thirsty, and vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.Radix Ophiopogonis is containing cupreol, aminoacid, volume glucose and glycoside.Can immunologic function be improved, have inhibitory action to various bacteria, pituitary adrenal system function can be strengthened, improve organism adaptation ability, have arrhythmia and the peripheral vascular effect of expansion, can hypoxia-bearing capability be improved, have hypoglycemic activity.
Fructus Schisandrae Chinensis is the mature fruit of magnoliaceae schisandra or schisandra chinensis.Sweet in the mouth, acid, warm in nature.Energy supplementing QI for promoting the production of body fluid, the kidney invigorating is nourished heart, and restrains astringent or styptic treatment for spontaneous sweating.For deficiency of vital energy Tianjin wound, the tired hyperhidrosis of body, cardiopalmus of losing heart, breathing with cough caused by insufficiency of lung-QI or deficiency of both the lung and kidney, or breath with cough with the passing of time, lung qi consumption wound, insufficiency of heart-YIN, severe palpitation, insomnia forgetfulness, instability of kidney QI, seminal emission, frequent micturition, or asthenia of both the spleen and kidney, incessant chronic diarrhea.Fructus Schisandrae Chinensis has the function of protection human five internal organs (heart, liver, spleen, lung, kidney), the fruit of this bittersweet, mutual generation of five phases, can play balanced action to human five internal organs's heart, liver, spleen, lung and kidney.
The tuber of the Pinellia Tenore aroid Rhizoma Pinelliae, be the important medical material of one in Chinese medicine treasure-house, the pungent loose warm-dryness syndrome of the Rhizoma Pinelliae is poisonous, main enter taste double enter lung, water of manageing it wets, lowering the adverse flow of QI, and kind taste damp-phlegm of dispelling.Water is wet to be gone, and the strong and sputum of spleen is from disappearing, and inverse gas falls then harmonization of the stomach and feeling of fullness vomiting from only, therefore is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the good medicine of dissolving lump and resolving mass.
Herba Cistanches is the fleshy stem of the dry zone scale leaf of Herba Cistanches, is a kind of parasitic plant colonizing in desert trees sacsaoul, red building root, not high to soil, moisture requirement, sweet in the mouth, salty, warm in nature.Energy kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.For insufficiency of kidney-YANG, essence and blood void is lost, and sexual impotence or infertile, soreness of the waist and knees, muscles and bones is unable, dryness of the intestine constipation.In addition, can also enhancing immunity, adjustment endocrine promotes metabolism, and enhancing development, reduces blood pressure, study of anti-atherogenic effect, has certain anti-aging effects.
Fructus Mume another name dark plum, yellow son, conjunction Chinese prunus mume (sieb.) sieb.et zucc., dry branch prunus mume (sieb.) sieb.et zucc. are the dry almost ripe fruit of rosaceae plant deciduous tree prunus mume (sieb.) sieb.et zucc..Sour in the mouth, micro-puckery, property is put down.Return liver, spleen, lung, stomach, large intestine channel.Matter profit is held back puckery, and astringe the lung, astringing intestine to stop diarrhea, promotes the production of body fluid, relieving colic caused by ascaris.For chronic cough of deficiency lung, chronic dysentery laxation, deficiency-heat is quenched one's thirst, ascariasis of biliary tract vomiting stomachache, ascariasis of biliary tract.Fructus Mume also has protection digestive function, antioxidation, purifies the blood and increases the function of appetite.
The Rhizoma Atractylodis Macrocephalae is the rhizome of the feverfew Rhizoma Atractylodis Macrocephalae.The Rhizoma Atractylodis Macrocephalae has air making-up and spleen enlivening, dampness diuretic, hidroschesis, antiabortive effect.For weakness of the spleen and stomach, the phlegm retention caused by insufficiency of the spleen water retention, edema and deficiency-weakness of spleen-QI, the symptoms such as frequent fetal movement.
Fructus Aurantii Immaturus is the dry young fruit of rutaceae Citrus aurantium Linn. and variety or Fructus Citri sinensis, and Fructus Aurantii Immaturus belongs to qi-regulating Chinese medicine, has dispelling the stagnated QI removing food stagnancy; Reduce phlegm except effect of painful abdominal mass.Cure mainly in stagnating and stop, feeling of fullness distending pain, constipation, heavy after dysentery, blocked-up chest, gastroptosis, uterine prolapse, proctoptosis etc.The extract of Fructus Aurantii Immaturus also has the function of antiinflammatory.Fructus Aurantii Immaturus is used for distension and fullness of the chest and abdomen.Fructus Aurantii Immaturus circulation of qi promoting effect of regulating the flow of vital energy is comparatively strong, therefore it is generally acknowledged that this product has dispelling the stagnated QI effect, and function circulation of qi promoting is stagnant, except distension.
Cortex Magnoliae Officinalis is the bark of Magnoliacea plant Cortex Magnoliae Officinalis and Mount Lushan Cortex Magnoliae Officinalis, root bark and branch skin, Cortex Magnoliae Officinalis another name pachydermia, pipe, magnolia hypoleuca, strong Piao, Cortex Magnoliae Officinalis, CORTEX MAGNOLIAE OFFICINALIS, Cortex Magnoliae Officinalis has circulation of qi promoting removing food stagnancy, dampness except effect that is full, lowering the adverse QI to relieve asthma, the effect that Cortex Magnoliae Officinalis has treatment stagnation of QI due to dyspepsia, abdominal distention constipation, retention of dampness in middle-JIAO, the vomiting and diarrhoea of gastral cavity painful abdominal mass, fullness in the chest to breath with cough, deficiency of vital energy body fluid deficiency person and anemia of pregnant woman are when being cautious use of Cortex Magnoliae Officinalis, Rhizoma Zingiberis makes for it, and Cortex Magnoliae Officinalis dislikes Rhizoma Alismatis, Mirabilitum crystallina, Sal Nitri.
Flos Caryophylli is Myrtaceae syzygium species plant Flos Caryophylli, with alabastrum and its fruit medicine.Alabastrum claims Flos Caryophylli or male Flos Caryophylli, and fruit claims Fructus Caryophylli or female Flos Caryophylli.Start in white at alabastrum, virescence gradually, can gather time finally in cerise.The alabastrum adopted removing bennet is dried.There is effect of warming middle-JIAO, warming the kidney, sending down the abnormal ascending QI, control singultus, vomiting, regurgitation, dysentery, trusted subordinate's cold type of pain, mass beside the umbilicus, hernia, ringworm.
Rhizoma Corydalis has another name called Rhizoma Corydalis, Rhizoma Corydalis, and be Papaveraceae Corydalis herbaceos perennial, Rhizoma Corydalis history is loaded in " Kaibao Bencao ", warm in nature, and acrid in the mouth is bitter, enters the heart, spleen, liver, lung, is the quality goods of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, is especially world-famous for effect of pain relieving.Li Shizhen (1518-1593 A.D.) concludes Rhizoma Corydalis in Compendium of Material Medica " invigorating blood circulation, promoting the circulation of QI, pain relieving, diuresis " four large effects, and praises highly Rhizoma Corydalis " can the stagnation of QI in promoting the circulation of blood, stasis in gas, therefore specially control upper and lower all pains all over the body ".The traditional Chinese medical science is thought, Rhizoma Corydalis pungent loose, hardship is let out, Wen Tong, both enters blood system, and enters edema caused by disorder of QI again, can gas in promoting the circulation of blood, again can blood in circulation of qi promoting, the smooth blood of gas, general rule is not bitterly.Clinical confirmation this product analgesic effect comparatively Olibanum, Myrrha, Oletum Trogopterori is strong, is the pain relieving good medicine in Chinese medicine, has a pain and abdominal pain during menstruation particularly imitates victory to gastral cavilty, and compatibility effect is better.
Fructus Toosendan is the medical material of a kind of uniqueness in Xinjiang, is Umbelliferae, herbaceos perennial.There is soothing the liver expelling the heat-evil, effect of promoting the circulation of QI to relieve pain.
Radix Glycyrrhizae is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L., Radix Glycyrrhizae contains number of chemical composition, and main component has glycyrrhizic acid, liquiritin etc., in TCM academic, carry out coordinating the actions of various ingredients in a prescription through conventional Radix Glycyrrhizae, Radix Glycyrrhizae has the effects such as heat-clearing and toxic substances removing, invigorating the spleen and replenishing QI, expelling phlegm for arresting cough.
Compared with prior art, the present invention has following technical advantage:
1, Chinese medicine composition of the present invention is compared with the medicine of other treatment chronic gastritis, in stomach warming nourishing the stomach, promoting the circulation of QI to relieve pain, reinforcing body resistance, damp eliminating sending down the abnormal ascending QI, circulation of qi promoting removing food stagnancy and tonifying speen and tonifying kidney, dispelling wind and heat pathogens etc., have more remarkable efficacy.
2, compared with the Chinese medicine composition of other treatment chronic gastritis, the specific aim of Chinese medicine composition of the present invention is stronger, and specially for the chronic gastritis of insufficiency of the spleen stomach weak type, and Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, untoward reaction and side effect significantly reduce, and therapeutic effect is better.
3, Chinese medicine composition of the present invention also has that compatibility science, preparation technology are simple, good effect, side effect are low, taking convenience and be easy to advantages such as applying.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.
embodiment 1:
The embodiment of the present invention 1 Chinese medicine composition is prepared from by the raw material of following parts by weight: the Radix Astragali 3 parts, Radix Codonopsis 6-part, Radix Ophiopogonis 3 parts, Fructus Schisandrae Chinensis 1 part, the Rhizoma Pinelliae 3 parts, Herba Cistanches 3 parts, Fructus Mume 6 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, Fructus Aurantii Immaturus 3 parts, Cortex Magnoliae Officinalis 3 parts, Flos Caryophylli 1 part, Rhizoma Corydalis 3 parts, Fructus Toosendan 3 parts and 1 part, Radix Glycyrrhizae.
Preparation method is as follows:
Take the Radix Astragali, Radix Codonopsis, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Rhizoma Pinelliae, Herba Cistanches, Fructus Mume, the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Flos Caryophylli, Rhizoma Corydalis, Fructus Toosendan and Radix Glycyrrhizae, add the water of initial feed 8 times of weight, soak 12 hours, backflow decoction 1 hour, filters, then adds the water of initial feed 3 times of weight, backflow decoction 1 hour, filter, obtain filtrate, merging filtrate, the Chinese medical concrete that relative density is 1.25 is concentrated under 50 DEG C of conditions, dry, pulverize into fine powder, obtain the embodiment of the present invention 1 Chinese medicine composition.Fine powder obtained above is crossed No. five sieves, remove thick fine powder, then add the water-soluble base polyethylene glycol 6000 of fine powder weight 10 times, mix homogeneously, heating, emulsifying obtains medicinal liquid, put into pill dripping machine and make dripping, add the condensed fluid liquid paraffin of fine powder weight 1/10, obtained pellet, wherein, condensed fluid and substrate are not miscible, after drop pill molding, removing liquid paraffin, and dry arrangement, carry out quality inspection, after qualified on inspection, packaging, obtains the drop pill of the embodiment of the present invention 1 Chinese medicine composition.
embodiment 2:
The embodiment of the present invention 2 Chinese medicine composition is prepared from by the raw material of following parts by weight: the Radix Astragali 15 parts, Radix Codonopsis 15 parts, Radix Ophiopogonis 10 parts, Fructus Schisandrae Chinensis 9 parts, the Rhizoma Pinelliae 9 parts, Herba Cistanches 9 parts, Fructus Mume 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Fructus Aurantii Immaturus 9 parts, Cortex Magnoliae Officinalis 9 parts, Flos Caryophylli 3 parts, Rhizoma Corydalis 15 parts, Fructus Toosendan 10 parts, 10 parts, Radix Glycyrrhizae.
Preparation method is as follows:
Take the Radix Astragali, Radix Codonopsis, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Rhizoma Pinelliae, Herba Cistanches, Fructus Mume, the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Flos Caryophylli, Rhizoma Corydalis, Fructus Toosendan and Radix Glycyrrhizae, add the water of initial feed 10 times of weight, soak 18 hours, backflow decoction 2 hours, filters, then adds the water of initial feed 5 times of weight, backflow decoction 2 hours, filter, obtain filtrate, merging filtrate, the Chinese medical concrete that relative density is 1.30 is concentrated under 55 DEG C of conditions, dry, pulverize into fine powder, obtain the embodiment of the present invention 2 Chinese medicine composition.Adopt the method for wet granulation, the Chinese medicine composition of embodiment 2 is made granule.Fine powder obtained above is crossed No. five sieves, remove thick fine powder, add adjuvant, adjuvant is filler Icing Sugar and wetting agent distilled water, fine powder and filler, the amount ratio of wetting agent is 1:1:1, obtain soft material processed, the standard of this soft material processed should be that hands is pinched agglomerating, namely light pressure falls apart, soft material processed is put into rotary extrusion type granulator, obtain wet granular, dry under 80 DEG C of conditions, obtain dry granule, cross No. one and screen out big particle, make uniform particles, carry out quality inspection, through after the assay was approved, pack, obtain the granule of the embodiment of the present invention 2 Chinese medicine composition.
embodiment 3:
The embodiment of the present invention 3 Chinese medicine composition is prepared from by the raw material of following parts by weight: the Radix Astragali 10 parts, Radix Codonopsis 10 parts, Radix Ophiopogonis 6 parts, Fructus Schisandrae Chinensis 5 parts, the Rhizoma Pinelliae 6 parts, Herba Cistanches 6 parts, Fructus Mume 9 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, Fructus Aurantii Immaturus 6 parts, Cortex Magnoliae Officinalis 6 parts, Flos Caryophylli 2 parts, Rhizoma Corydalis 9 parts, Fructus Toosendan 6 parts, 5 parts, Radix Glycyrrhizae.
Preparation method is as follows:
Take the Radix Astragali, Radix Codonopsis, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Rhizoma Pinelliae, Herba Cistanches, Fructus Mume, the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Flos Caryophylli, Rhizoma Corydalis, Fructus Toosendan and Radix Glycyrrhizae, add the water of initial feed 12 times of weight, soak 24 hours, backflow decoction 3 hours, filters, then adds the water of initial feed 6 times of weight, backflow decoction 3 hours, filter, obtain filtrate, merging filtrate, the Chinese medical concrete that relative density is 1.35 is concentrated under 60 DEG C of conditions, dry, pulverize into fine powder, obtain the embodiment of the present invention 3 Chinese medicine composition.Fine powder is crossed No. five sieves, remove thick fine powder, add diluent lactose by the equivalent method of progressively increasing, the amount ratio of fine powder and diluent is 1:100, obtains 100 times and falls apart, cross No. six sieves, obtain loose powder, carry out quality inspection, after quality inspection is qualified, packaging, obtains the powder of the embodiment of the present invention 3 Chinese medicine composition.
clinical observation on the therapeutic effect
1, case selection: in 400 routine insufficiency of the spleen stomach weak type chronic gastritis clinical volunteers patients, male patient 200 example, female patient 200 example, age bracket be 20-70 year, the mean age is 45 years old, and all patients are no difference of science of statistics in sex, age, the course of disease.
2, tcm diagnosis standard:
Main syndromes: 1. vague epigastralgia; 2. pain relieved by pressing happiness of having a stomachache is warm; 3. feeling of distension and oppression feeling of fullness after food; 4. appetite stimulator; 5. loose stool diarrhoea; 6. weak extremity are aching and limp.
Secondary syndrome: 1. gastric mucosa is red and white with Bai Weizhu; 2. mucus is thin and many; 3. gastric acid is on the low side.
Picture of the tongue pulse condition: 1. body of the tongue is light red, white and thin fur or white, has indentation; 2. deep-thready pulse.
Pattern of syndrome is determined: 1. possess main symptom 3, tongue arteries and veins meets substantially; 2. possess primary symptom two and time disease 1, tongue arteries and veins meets substantially; Possess any 1 can determine.
3, efficacy assessment standard:
Cure: the stomach pain symptoms such as stomach dull pain, distending pain disappear, abdominal distention after meal, vomiting disappear, and gastric motility recovers, and metabolism recovers normal;
Effective:: stomach pain symptom alleviates, and attack times reduces, and gastric motility recovers to some extent;
Invalid:: symptom is without improvement or aggravation;
Total effective rate=(cure+effective)/total number of cases × 100%.
4, instructions of taking: 400 patients are divided into 4 groups at random, often organize 100 people, be respectively treatment A group, treatment B group, treatment C group and matched group, the drop pill (0.3g*60 grain/bottle) that the oral embodiment of the present invention 1 for the treatment of A group prepares, 3 times on the one, one time 4; The granule that the oral embodiment of the present invention 2 for the treatment of B group prepares, each 2g, every day 3 times; The powder that the oral embodiment of the present invention 3 for the treatment of C group prepares, each 2g, every day 3 times, serve on 2 months respectively; Matched group takes Gastritis granule (monarch mourning hall, Shaanxi pharmaceutical Co. Ltd, the accurate word Z20053594 of traditional Chinese medicines), oral, one time 8,3 times on the one, take 2 months.
5, therapeutic outcome: as shown in table 1.
table 1 therapeutic outcome
This test adopts Gastritis granule as positive controls, the main component of Gastritis granule comprises the Radix Paeoniae Alba, Radix Glycyrrhizae, Ramulus Cinnamomi, Rhizoma Alpiniae Officinarum, Rhizoma Coptidis, Radix Bupleuri, there is soothing liver-QI stomach function regulating, effect of relieving spasm to stop pain, cures mainly gastralgia, vomiting and nausea pantothenic acid, burn discomfort, there is above symptom for chronic gastritis, by comparing with the therapeutic effect of Chinese medicine composition of the present invention, the curative effect of the empty stomach weak type chronic gastritis aspect of traditional Chinese medicine composition for treating of the present invention can be found out.Make inventor surprisingly, the cure rate of Chinese medicine composition of the present invention reaches more than 80.0%, total effective rate reaches more than 90.0%, far above cure rate and the total effective rate of matched group, wherein best with the therapeutic effect for the treatment of C group, visible, the good effect of Chinese medicine composition of the present invention, cure rate is high, can be used as the drug use for the treatment of empty stomach weak type chronic gastritis.
Owing to describing the present invention by above preferred embodiment, in spirit of the present invention and/or scope, any for replacement/of the present invention or combination implement the present invention, be all apparent for a person skilled in the art, and be included among the present invention.
Claims (7)
1. treat a Chinese medicine composition for insufficiency of the spleen stomach weak type chronic gastritis, it is characterized in that being prepared from by the raw material of following weight portion: Radix Astragali 3-15 part, Radix Codonopsis 6-15 part, Radix Ophiopogonis 3-10 part, Fructus Schisandrae Chinensis 1-9 part, Rhizoma Pinelliae 3-9 part, Herba Cistanches 3-9 part, Fructus Mume 6-12 part, Rhizoma Atractylodis Macrocephalae 6-12 part, Fructus Aurantii Immaturus 3-9 part, Cortex Magnoliae Officinalis 3-9 part, Flos Caryophylli 1-3 part, Rhizoma Corydalis 3-15 part, Fructus Toosendan 3-10 part and Radix Glycyrrhizae 1-10 part.
2. the Chinese medicine composition of the insufficiency of the spleen stomach weak type chronic gastritis for the treatment of as claimed in claim 1, is characterized in that being prepared from by the raw material of following weight portion: the Radix Astragali 3 parts, Radix Codonopsis 6-part, Radix Ophiopogonis 3 parts, Fructus Schisandrae Chinensis 1 part, the Rhizoma Pinelliae 3 parts, Herba Cistanches 3 parts, Fructus Mume 6 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, Fructus Aurantii Immaturus 3 parts, Cortex Magnoliae Officinalis 3 parts, Flos Caryophylli 1 part, Rhizoma Corydalis 3 parts, Fructus Toosendan 3 parts and 1 part, Radix Glycyrrhizae.
3. the Chinese medicine composition of the insufficiency of the spleen stomach weak type chronic gastritis for the treatment of as claimed in claim 1, is characterized in that being prepared from by the raw material of following weight portion: the Radix Astragali 15 parts, Radix Codonopsis 15 parts, Radix Ophiopogonis 10 parts, Fructus Schisandrae Chinensis 9 parts, the Rhizoma Pinelliae 9 parts, Herba Cistanches 9 parts, Fructus Mume 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Fructus Aurantii Immaturus 9 parts, Cortex Magnoliae Officinalis 9 parts, Flos Caryophylli 3 parts, Rhizoma Corydalis 15 parts, Fructus Toosendan 10 parts, 10 parts, Radix Glycyrrhizae.
4. the Chinese medicine composition of the insufficiency of the spleen stomach weak type chronic gastritis for the treatment of as claimed in claim 1, is characterized in that being prepared from by the raw material of following weight portion: the Radix Astragali 10 parts, Radix Codonopsis 10 parts, Radix Ophiopogonis 6 parts, Fructus Schisandrae Chinensis 5 parts, the Rhizoma Pinelliae 6 parts, Herba Cistanches 6 parts, Fructus Mume 9 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, Fructus Aurantii Immaturus 6 parts, Cortex Magnoliae Officinalis 6 parts, Flos Caryophylli 2 parts, Rhizoma Corydalis 9 parts, Fructus Toosendan 6 parts, 5 parts, Radix Glycyrrhizae.
5. the Chinese medicine composition of the treatment insufficiency of the spleen stomach weak type chronic gastritis as described in as arbitrary in claim 1-4, is characterized in that: described Chinese medicine composition is oral formulations.
6. the Chinese medicine composition of the insufficiency of the spleen stomach weak type chronic gastritis for the treatment of as claimed in claim 5, is characterized in that: described oral formulations is tablet, capsule, drop pill, granule, powder or oral liquid.
7. one kind prepare as arbitrary in claim 1-4 as described in the method for Chinese medicine composition for the treatment of insufficiency of the spleen stomach weak type chronic gastritis, it is characterized in that comprising following processing step: take the Radix Astragali, Radix Codonopsis, Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Rhizoma Pinelliae, Herba Cistanches, Fructus Mume, the Rhizoma Atractylodis Macrocephalae, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Flos Caryophylli, Rhizoma Corydalis, Fructus Toosendan and Radix Glycyrrhizae, add the water of initial feed 8-12 times of weight, soak 12-24 hour, backflow decocts 1-3 hour, filter, add the water of initial feed 3-6 times of weight again, backflow decocts 1-3 hour, filter, obtain filtrate, merging filtrate, the Chinese medical concrete that relative density is 1.25-1.35 is concentrated under 50 DEG C of-60 DEG C of conditions, dry, be ground into fine powder, obtain Chinese medicine composition of the present invention, add adjuvant, clinical required preparation is prepared into by modern medicines preparation method.
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Cited By (5)
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| CN105362646A (en) * | 2015-12-10 | 2016-03-02 | 杨献美 | Pharmaceutical preparation for treating spleen-stomach deficiency type chronic gastritis |
| CN105412564A (en) * | 2015-12-10 | 2016-03-23 | 杨献美 | Method for preparing pharmaceutic preparation for treating spleen-deficiency stomach-weakness type chronic gastritis |
| CN105920275A (en) * | 2016-07-06 | 2016-09-07 | 丘利锦 | Traditional Chinese medicine composition for treating chronic gastritis |
| CN107496657A (en) * | 2017-09-08 | 2017-12-22 | 合肥申仁养殖有限公司 | A kind of Chinese medicine composition for treating pig spleen-stomach deficiency-cold chronic gastritis |
| CN107898853A (en) * | 2017-12-21 | 2018-04-13 | 广西中医药大学 | A kind of strong drug composition for treating antral gastritis |
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