CN103784802A - Traditional Chinese medicine composition for treating diabetes - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for treating diabetes. The traditional Chinese medicine composition is prepared from medicinal materials such as angelica sinensis, radix puerariae, ginseng, Chinese yam, citronella and radix sophorae tonkinensis. The traditional Chinese medicine composition for treating diabetes is based on scientific compatibility; a plurality of traditional Chinese medicinal materials are selected elaborately and scientifically and combined with each other to form the traditional Chinese medicine composition which is capable of effectively treating the diabetes; and the composition is scientific in formula, rational in compatibility and obvious in treatment effect, and also safe and reliable, free of side effect and prone to being accepted by patients and the like.

Description

A kind of Chinese medicine composition for the treatment of diabetes

Technical field

The present invention relates to tcm field, specifically, relate to a kind of Chinese medicine composition for the treatment of diabetes.

Background technology

Diabetes have become a kind of global disease at present, and have the trend of further rising, and wherein type 2 diabetes mellitus accounts for 90%-95%.The daily main therapeutic modality of most of type 2 diabetes mellitus patient is to control blood glucose, but even by existing multiple oral drug therapy and control, current China still has and exceedes 70% patient and cannot reach desirable glycemic control.The weak point of Traditional regimen comprise put on weight, risk of hypoglycemia, gastrointestinal untoward reaction.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine composition for the treatment of diabetes.

In order to realize object of the present invention, the invention provides a kind of Chinese medicine composition for the treatment of diabetes, it is made up of the material of following weight proportioning: 2 parts of Radix Angelicae Sinensis, 2 parts of Radix Puerariaes, 8 parts of Radix Ginsengs, 25 parts of Cor Cervi grass, 13 parts of the Radixs Astragali, 13 parts of Galla Chinensiss, 13 parts of Hirudos, 20 parts of fly grass, 13 parts of Rhizoma Dioscoreaes, 13 parts of Cortex Mori, 8 parts, Semen phaseoli radiati, 13 parts of Semen Litchis, 8 parts of Herba Euphorbiae Humifusaes, 8 parts of Herba Catharanthi Roseis, 8 parts of Ramulus Euonymis, 13 parts of Rhizoma Coptidis, 8 parts of Fructus Corni, 8 parts of Herba Agrimoniaes, 30 parts of Radix seu Herba Pegaeophytonis Scapiflori, 8 parts, Herba Cymbopogonis Citrari, 2 parts, Semen sojae atricolor, 2 parts of Rhizoma Chuanxiongs, 2 parts of Carapax et Plastrum Testudiniss, 2 parts of Carapax Trionycis, 2 parts of Rhizoma Paridis, 2 parts of Radix Sophorae Tonkinensiss, 2 parts of Herba Moslaes, 2 parts of Fructus Broussonetiaes, 2 parts of the Rhizoma Atractylodis Macrocephalaes, 2 parts of Rhizoma Alismatis, 2 parts of Stigma Maydis, 2 parts of Radix Ophiopogonis, 5 parts of Endothelium Corneum Gigeriae Galli, 5 parts of Rhizoma Atractylodis, 25 parts of grass dragons, 5 parts, the Radix Rehmanniae, 5 parts of the Rhizoma Anemarrhenaes, 5 parts of Pollen Pinis, 5 parts of Fructus Lycii, 5 parts, Semen Persicae, 5 parts of Radix Codonopsis, 5 parts of Radix Platycodoniss, 5 parts of Radix Scrophulariae, 2 parts of 5 parts of Semen Astragali Complanatis and Cordyceps.

Preferably, described medicine can be tablet, dispersible tablet, powder, instant, unguentum or decoction.

In compositions of the present invention, Cor Cervi grass (Latin formal name used at school: Balanophora dioica R.Br.ex Royle[B.affinis Griff.]) nature and flavor hardship, puckery, warm in nature, has the effects such as kidney invigorating and YANG supporting, spleen invigorating are regulated the flow of vital energy, hemostasis; Fly grass (Latin formal name used at school Silene gallica Linn.) nature and flavor are pungent, puckery, cool, have clearing away heat-damp and promoting diuresis, the effects such as removing toxic substances and promoting subsidence of swelling; Radix seu Herba Pegaeophytonis Scapiflori (Latin formal name used at school Radix seu Herba Pegaeophytonis Scapiflori) nature and flavor acrid in the mouth, pungent, cold in nature, has the effects such as heat-clearing and toxic substances removing, hemostasis, detumescence; Grass dragon (Latin formal name used at school Ludwigia linifolia Poir.) nature and flavor are light, cool, have the effect such as heat-clearing and toxic substances removing, removing the necrotic tissue and promoting granulation, and above-mentioned medical material is monarch drug.Radix Astragali nature and flavor are sweet, tepor, have the effects such as benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, holder skin ulcer granulation promoting, inducing diuresis to remove edema; Hirudo nature and flavor are salty, bitter, flat, for what lump in the abdomen, blood stasis amenorrhea and traumatic injury etc.; Galla Chinensis nature and flavor acid, puckery, cold, for chronic cough of deficiency lung, lung-heat phlegmatic cough, chronic diarrhea chronic dysentery, night sweat, quenches one's thirst etc.; Rhizoma Dioscoreae nature and flavor are sweet flat, have the effect such as supplementing QI and nourishing YIN, spleen reinforcing lung kidney; Cortex Mori nature and flavor are sweet, cold, have the effect such as eliminating pathogen from the lung for relieving asthma, line water detumescence; Sweet in flavor and warm in property, the micro-hardship of Semen Litchi (Latin formal name used at school SEMEN LITCHI), has the effect such as promoting QI to circulate and dispersing the agglomeration of the pathogens, cold-dispelling pain-relieving; Rhizoma Coptidis nature and flavor hardship, cold, is usually used in the cards such as the diarrhoea of the intestines and stomach due to damp and hot, dysentery, vomiting, and above-mentioned medical material is ministerial drug.Ramulus Euonymi (Latin formal name used at school Euonymus alatus) nature and flavor bitter, acrid, cold, have the effects such as removing blood stasis stimulates the menstrual flow, removing toxic substances and promoting subsidence of swelling, parasite killing; Herba Euphorbiae Humifusae nature and flavor are pungent, flat, the effect such as there is heat-clearing and toxic substances removing, dampness removing jaundice eliminating, invigorate blood circulation; Semen phaseoli radiati sweet in the mouth is cold in nature, the thick the intestines and stomach of energy, profit skin, the five internal organs and taste taste; Radix Ginseng sweet and slightly bitter taste, can strongly invigorating primordial QI, invigorating the spleen to benefit the lung, has promoting the production of body fluid to quench thirst, effects such as Fructus Alpiniae Oxyphyllae of calming the nerves; Herba Catharanthi Rosei property mildly bitter flavor is cool, has the effects such as suppressing the hyperactive liver and subsiding YANG, antitumor, tranquillizing and allaying excitement, diuresis; The acid of Fructus Corni nature and flavor, puckery, tepor, have the effect such as liver and kidney tonifying, essence astringing and desertion stemming; Herba Agrimoniae nature and flavor are pained and put down, and have the effects such as astringing to arrest bleeding, tonify deficiency, removing food stagnancy, dysentery relieving; Herba Cymbopogonis Citrari (Latin formal name used at school Mosla chinensis Maxim) nature and flavor are pungent, warm, have dispelling wind to relieve the exterior syndrome, wind-damp dispelling, loose cool effect such as cold, and above-mentioned medical material is adjuvant drug.Radix Angelicae Sinensis nature and flavor sweet in the mouth, pungent, warm in nature, for heart-liver blood deficiency, shallow complexion, dizzy cardiopalmus etc.; Radix Puerariae nature and flavor are sweet, pungent, cool, have relieving muscles diaphoresis, invigorating YANG QI to promote eruption, antipyretic effect such as promote the production of body fluid; Semen sojae atricolor nature and flavor are sweet, flat, have invigorate blood circulation, diuretic, dispel the wind, the effect such as heat-clearing and toxic substances removing; Rhizoma Chuanxiong nature and flavor are pungent, warm, have the effect such as blood-activating and qi-promoting, wind-expelling pain-stopping; Carapax et Plastrum Testudinis nature and flavor are salty, sweet, flat, have YIN nourishing, YANG hyperactivity suppressing, the kidney invigorating, the effects such as strong bone; Carapax Trionycis nature and flavor are salty, are slightly cold, and have nourishing YIN for suppressing the hyperactive YANG,

Hard masses softening and resolving, brings down a fever except effects such as steamings; Rhizoma Paridis nature and flavor are slightly cold, bitter in the mouth, have the effects such as heat-clearing and toxic substances removing, reducing swelling and alleviating pain, the arresting convulsion of cool liver; Radix Sophorae Tonkinensis nature and flavor bitter cold, has the effect such as heat-clearing and toxic substances removing, relieving sore throat and diminishing swelling; Herba Moslae (Latin formal name used at school Elsholtzia ciliata (Thunb.) Hyland.) nature and flavor are pungent, and tepor, has merit and arrogate to oneself diaphoresis expelling summer-heat, row water wet dissipation, and stomach warming is adjusted medium effect; Fructus Broussonetiae is cold in nature, and sweet in the mouth has the effects such as the kidney invigorating liver heat removing, improving eyesight, diuresis; Rhizoma Atractylodis Macrocephalae nature and flavor hardship, sweet, warm, has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, the effect such as antiabortive; Rhizoma Alismatis is sweet in flavor and cold in property, has the effects such as patent water channel, infiltration are wet; Stigma Maydis nature and flavor are sweet flat, have diuresis, expel the heat-evil, effect of suppressing the hyperactive liver, function of gallbladder promoting; Sweet, the micro-hardship of nature and flavor Radix Ophiopogonis, is slightly cold, and for dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation; Endothelium Corneum Gigeriae Galli is hidden and is returned through sweet, cold.Return spleen, stomach, small intestinal, urinary bladder channel, it is stagnant that function cures mainly removing food stagnancy, strengthening the spleen and stomach.Control food stagnation distension, vomiting regurgitation, dysentery, infantile malnutrition, quenches one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha; Rhizoma Atractylodis nature and flavor acrid in the mouth, hardship, warm in nature, fragrance is dry strong, interior can removing dampness turbid strongly fragrant, the heresy of the loose rheumatism of external enwergy, thus can be drying damp and strengthening spleen, expelling wind and removing dampness; Radix Rehmanniae sweet in the mouth bitterness Great Cold, there is the effects such as YIN nourishing, clearing away heat and promoting production of body fluid, cooling blood for hemostasis; Rhizoma Anemarrhenae nature and flavor bitter cold and not dry, has the effects such as clearing away stomach-heat; Pollen Pini (Pollen Pini is the pollen of pinaceae plant Pinus massoniana Lamb, Pinus tabuliformis or its congener) nature and flavor are sweet, and temperature, has the QI invigorating of dispeling the wind, removing dampness, the effects such as hemostasis; Fructus Lycii sweet in the mouth, property is flat, has the effect such as nourishing the liver and kidney, replenishing vital essence to improve eyesight; Sweet flat, the bitter in the mouth of Semen Persicae, the effect that there is blood stasis removing and clots absorbing, moisturizes laxation; Radix Codonopsis nature and flavor are sweet flat, and main function is air making-up and spleen enlivening; Radix Platycodonis bitter in the mouth, pungent, property are flat, have lung qi dispersing, sore-throat relieving, eliminate the phlegm, the effect such as evacuation of pus; Salty being slightly cold of Radix Scrophulariae nature and flavor sweetness and bitterness, has clearing away heat and cooling blood, YIN nourishing, effect of eliminating fire and detoxication; Semen Astragali Complanati nature and flavor are sweet, warm, have the effects such as liver and kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, improving eyesight; Cordyceps nature and flavor sweet in the mouth, warm in nature, has foster lung yin, kidney-replenishing, relieving cough and resolving phlegm, anticancer anti-old effect, and above-mentioned medical material is for making medicine.So medical material is brought into play drug effect jointly according to the principle of monarch.

The Chinese medicine composition for the treatment of diabetes of the present invention carries out science compatibility, meticulously filter out multidigit Chinese crude drug, the science of carrying out compatibility, can effectively treat diabetes, the prescription science of the present composition, compatibility is reasonable, therapeutic effect is obvious, have safe and reliablely, have no side effect, patient's feature such as take like a shot.

The specific embodiment

Embodiment:

Take 20 grams of Radix Angelicae Sinensis, 20 grams of Radix Puerariaes, 80 grams of Radix Ginsengs, 250 grams of Cor Cervi grass, 130 grams of the Radixs Astragali, 130 grams of Galla Chinensiss, 130 grams of Hirudos, 200 grams of fly grass, 130 grams of Rhizoma Dioscoreaes, 130 grams of Cortex Mori, 80 grams, Semen phaseoli radiati, 130 grams of Semen Litchis, 80 grams of Herba Euphorbiae Humifusaes, 80 grams of Herba Catharanthi Roseis, 80 grams of Ramulus Euonymis, 130 grams of Rhizoma Coptidis, 80 grams of Fructus Corni, 80 grams of Herba Agrimoniaes, 300 grams of Radix seu Herba Pegaeophytonis Scapiflori, 80 grams, Herba Cymbopogonis Citrari, 20 grams, Semen sojae atricolor, 20 grams of Rhizoma Chuanxiongs, 20 grams of Carapax et Plastrum Testudiniss, 20 grams of Carapax Trionycis, 20 grams of Rhizoma Paridis, 20 grams of Radix Sophorae Tonkinensiss, 20 grams of Herba Moslaes, 20 grams of Fructus Broussonetiaes, 20 grams of the Rhizoma Atractylodis Macrocephalaes, 20 grams of Rhizoma Alismatis, 20 grams of Stigma Maydis, 20 grams of Radix Ophiopogonis, 50 grams of Endothelium Corneum Gigeriae Galli, 50 grams of Rhizoma Atractylodis, 250 grams of grass dragons, 50 grams, the Radix Rehmanniae, 50 grams of the Rhizoma Anemarrhenaes, 50 grams of Pollen Pinis, 50 grams of Fructus Lycii, 50 grams, Semen Persicae, 50 grams of Radix Codonopsis, 50 grams of Radix Platycodoniss, 50 grams of Radix Scrophulariae, 20 grams of 50 grams of Semen Astragali Complanatis and Cordyceps, pulverize, cross 100 mesh sieves, add 50 grams of lactose, divide and install in 300 bags, obtain powder of the present invention.

Experimental example

Physical data

Type 2 diabetes mellitus patient 40 examples of selecting outpatient service and being in hospital, diabetes meet the 2 type glycosuria diagnostic criterias that WHO formulates in 1999.Be divided into 2 groups, treatment group 20 examples, wherein male 10 examples, female's 10 examples, year at age (56 ± 6), diabetic duration 2-10; Matched group 20 examples, wherein male 9 examples, female's 11 examples, year at age (57 ± 5), diabetic duration 2-11.2 groups of difference not statistically significants on age, sex, severity extent (P > 0.05), have comparability.

2 groups of patients all carry out health education in diabetes, diabetic diet and appropriate exercise, and treatment group adopts the powder of preparing in embodiment to treat, and oral 2 times of every day, each oral one bag, treats 3 months.Matched group adopts phosphoric acid sitagliptin to treat, and every day 1 time, each oral 100mg, treats 3 months.

Detect index

Detect 2 groups of fasting glucose (FBG), 2 hours blood glucoses (2-hPPG) after the meal of every 2 weeks during treating, HbAlc, hypoglycemia incidence rate, body weight change situation.

Statistical procedures

Measurement data represents by mean ± standard deviation, relatively adopts t check between group, uses SPSS12.0 statistics software, and P < 0.05 has significant difference for adding up.

Treatment group is better than matched group (P < 0.05) in glycemic control; Aspect reduction HbAlc, be better than matched group (P < 0.05); Treatment group is being better than matched group (P < 0.05) aspect the risk of minimizing hypoglycemia and body weight increase.In table 1.

The smelting of table 12 group treat before and after fasting glucose, 2 hours blood glucoses, HbA after the meal _1c, hypoglycemia incidence rate, body weight change situation comparison (mean ± standard deviation)

Untoward reaction is observed

During treating, patient is carried out to following monitoring, find the no abnormality seen results such as each group of blood, defecation routine, electrocardiogram, hepatic and renal function inspection.

Claims (2)

1. treat the Chinese medicine composition of diabetes for one kind, it is characterized in that, it is made up of the material of following weight proportioning: 2 parts of Radix Angelicae Sinensis, 2 parts of Radix Puerariaes, 8 parts of Radix Ginsengs, 25 parts of Cor Cervi grass, 13 parts of the Radixs Astragali, 13 parts of Galla Chinensiss, 13 parts of Hirudos, 20 parts of fly grass, 13 parts of Rhizoma Dioscoreaes, 13 parts of Cortex Mori, 8 parts, Semen phaseoli radiati, 13 parts of Semen Litchis, 8 parts of Herba Euphorbiae Humifusaes, 8 parts of Herba Catharanthi Roseis, 8 parts of Ramulus Euonymis, 13 parts of Rhizoma Coptidis, 8 parts of Fructus Corni, 8 parts of Herba Agrimoniaes, 30 parts of Radix seu Herba Pegaeophytonis Scapiflori, 8 parts, Herba Cymbopogonis Citrari, 2 parts, Semen sojae atricolor, 2 parts of Rhizoma Chuanxiongs, 2 parts of Carapax et Plastrum Testudiniss, 2 parts of Carapax Trionycis, 2 parts of Rhizoma Paridis, 2 parts of Radix Sophorae Tonkinensiss, 2 parts of Herba Moslaes, 2 parts of Fructus Broussonetiaes, 2 parts of the Rhizoma Atractylodis Macrocephalaes, 2 parts of Rhizoma Alismatis, 2 parts of Stigma Maydis, 2 parts of Radix Ophiopogonis, 5 parts of Endothelium Corneum Gigeriae Galli, 5 parts of Rhizoma Atractylodis, 25 parts of grass dragons, 5 parts, the Radix Rehmanniae, 5 parts of the Rhizoma Anemarrhenaes, 5 parts of Pollen Pinis, 5 parts of Fructus Lycii, 5 parts, Semen Persicae, 5 parts of Radix Codonopsis, 5 parts of Radix Platycodoniss, 5 parts of Radix Scrophulariae, 2 parts of 5 parts of Semen Astragali Complanatis and Cordyceps.

2. the Chinese medicine composition for the treatment of diabetes according to claim 1, is characterized in that, described medicine can be tablet, dispersible tablet, powder, instant, unguentum or decoction.