CN1559528A - Medicine for treating child diarrhea and its preparation method - Google Patents
Medicine for treating child diarrhea and its preparation method Download PDFInfo
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- CN1559528A CN1559528A CNA2004100141862A CN200410014186A CN1559528A CN 1559528 A CN1559528 A CN 1559528A CN A2004100141862 A CNA2004100141862 A CN A2004100141862A CN 200410014186 A CN200410014186 A CN 200410014186A CN 1559528 A CN1559528 A CN 1559528A
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- radix
- medicine
- infantile diarrhea
- treatment
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- 239000003814 drug Substances 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims description 23
- 206010012735 Diarrhoea Diseases 0.000 title abstract description 4
- 229940079593 drug Drugs 0.000 title description 5
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 33
- 239000007938 effervescent tablet Substances 0.000 claims abstract description 21
- 229920002472 Starch Polymers 0.000 claims abstract description 11
- 239000008107 starch Substances 0.000 claims abstract description 11
- 235000019698 starch Nutrition 0.000 claims abstract description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 40
- 208000019637 Infantile Diarrhea Diseases 0.000 claims description 34
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 28
- 239000000047 product Substances 0.000 claims description 18
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 16
- 239000000706 filtrate Substances 0.000 claims description 15
- 239000000796 flavoring agent Substances 0.000 claims description 14
- 235000019634 flavors Nutrition 0.000 claims description 14
- 239000008361 herbal raw material Substances 0.000 claims description 14
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 14
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 239000008187 granular material Substances 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 12
- 239000000341 volatile oil Substances 0.000 claims description 12
- 241000756943 Codonopsis Species 0.000 claims description 9
- 229920001353 Dextrin Polymers 0.000 claims description 9
- 239000004375 Dextrin Substances 0.000 claims description 9
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 9
- 235000019425 dextrin Nutrition 0.000 claims description 9
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 8
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 8
- 239000001530 fumaric acid Substances 0.000 claims description 8
- 239000001630 malic acid Substances 0.000 claims description 8
- 235000011090 malic acid Nutrition 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 8
- 239000007921 spray Substances 0.000 claims description 7
- RXUWDKBZZLIASQ-UHFFFAOYSA-N Puerarin Natural products OCC1OC(Oc2c(O)cc(O)c3C(=O)C(=COc23)c4ccc(O)cc4)C(O)C(O)C1O RXUWDKBZZLIASQ-UHFFFAOYSA-N 0.000 claims description 6
- 238000004821 distillation Methods 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- HKEAFJYKMMKDOR-VPRICQMDSA-N puerarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 HKEAFJYKMMKDOR-VPRICQMDSA-N 0.000 claims description 6
- 238000004064 recycling Methods 0.000 claims description 6
- 238000001694 spray drying Methods 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 abstract description 2
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 abstract 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 abstract 1
- 241000219780 Pueraria Species 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- ZFTFAPZRGNKQPU-UHFFFAOYSA-N dicarbonic acid Chemical compound OC(=O)OC(O)=O ZFTFAPZRGNKQPU-UHFFFAOYSA-N 0.000 abstract 1
- 229960004756 ethanol Drugs 0.000 description 14
- 238000000034 method Methods 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 239000007788 liquid Substances 0.000 description 5
- 239000002552 dosage form Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000013558 reference substance Substances 0.000 description 4
- 239000006188 syrup Substances 0.000 description 4
- 235000020357 syrup Nutrition 0.000 description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 206010003549 asthenia Diseases 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 230000004206 stomach function Effects 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
- 244000303040 Glycyrrhiza glabra Species 0.000 description 1
- 208000032754 Infant Death Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 241000238370 Sepia Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 229960000935 dehydrated alcohol Drugs 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- FYGDTMLNYKFZSV-MRCIVHHJSA-N dextrin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1O[C@@H]1[C@@H](CO)OC(O[C@@H]2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-MRCIVHHJSA-N 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 230000003760 hair shine Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 235000011477 liquorice Nutrition 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
A Chinese medicine in the form of effervescent tablet for treating infantal diarrhea is prepared from 7 Chinese-medicinal materials including pilose asiabell root, pueraria root, liquorice root, etc and 3 medicinal additives: starch, dicarbonate and citric acid.
Description
Technical field
The present invention relates to a kind of is the pharmaceutical preparation of raw material with the Chinese herbal medicine, particularly a kind of medicine for the treatment of infantile diarrhea; The invention still further relates to the preparation method of this medicine.
Background technology
Infantile diarrhea is commonly encountered diseases, the frequently-occurring disease of harm child health, is seriously endangering children's health.According to statistics, diarrhoea is the third-largest reason of infant death, and diarrhoea causes multiple diseases such as malnutrition, infection, and infant life is constituted grave danger.In Chinese children, diarrhoeal diseases is second commonly encountered diseases, the frequently-occurring disease that is only second to respiratory tract infection, and 2 years old the highest with interior children's's sickness rate.And infantile diarrhea is a process of morbidity repeatedly, and a lot of children are more than once ill.
In the prior art, the peaceful syrup of infantile diarrhea is a kind of typical Chinese medicine for the treatment of infantile diarrhea.It makes syrup by Chinese herbal medicine such as Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Puerariae, Radix Glycyrrhizae, Herba Pogostemonis, the Radix Aucklandiae with medical accessories such as sucrose, sodium benzoate.These product are dark-brown thick liquid; Gas perfume (or spice), it is sweet, little puckery to distinguish the flavor of.Its usage and consumption: oral, youngster measures 10ml one time more than 10 years old, and 2 times on the one, the child is cut down according to the circumstance under 10 years old warp.The peaceful syrup of infantile diarrhea has air making-up and spleen enlivening, and the effect that stomach function regulating promotes the production of body fluid can be used for the infantile diarrhea vomiting, and flesh heat is thirsty, dyspepsia, the asthenia of becoming thin, pale tongue with white fur.Its defective is that said preparation is a liquid preparation, and dosage form falls behind, and syrup is stable poor, contains antiseptic and a large amount of sucrose, can produce untoward reaction after some patient takes, and influences the safety of preparation.So exploitation preparation stabilization, drug safety, dosage are accurate, quality controllable, curative effect reliably in preparation significant.
Summary of the invention
Technical problem to be solved by this invention is at the deficiencies in the prior art, and a kind of dosage form novelty, preparation stabilization, drug safety, dosage is accurate, quality controllable, curative effect is treated infantile diarrhea reliably medicine are provided.
The present invention also provides the preparation method of this medicine.
Technical problem to be solved by this invention is to realize by following technical scheme.The present invention is a kind of medicine for the treatment of infantile diarrhea, is characterized in, it is the medicament of being made by following weight percentages, and described pharmaceutical formulation is an effervescent tablet,
Herbal raw material:
Radix Codonopsis 10-20% Rhizoma Atractylodis Macrocephalae 15-25% Poria 15 25%
Radix Puerariae 20-30% Radix Glycyrrhizae 5-10% Herba Pogostemonis 5-10%
Radix Aucklandiae 5-10%
Medical accessory:
Starch or dextrin 1-10% sodium bicarbonate 2-10%
Citric acid or fumaric acid or malic acid 0.5-5%.
Technical problem to be solved by this invention can also further realize according to following technical scheme.Above-described a kind of medicine for the treatment of infantile diarrhea is characterized in, the percentage by weight of each raw material is,
Herbal raw material:
Radix Codonopsis 15% Rhizoma Atractylodis Macrocephalae 20% Poria 20%
Radix Puerariae 24%g Radix Glycyrrhizae 5% Herba Pogostemonis 5%
The Radix Aucklandiae 5%;
Medical accessory:
Starch or dextrin 2% sodium bicarbonate 3%
Citric acid or fumaric acid or malic acid 1%.
The invention also discloses a kind of preparation method for the treatment of the medicine of infantile diarrhea, be characterized in, get above seven flavor herbal raw materials, the Rhizoma Atractylodis Macrocephalae, Herba Pogostemonis, the Radix Aucklandiae add the water distillation, extract volatile oil; Medicinal residues and all the other four flavors decoct with water 2-4 time, and each 1-3 hour, collecting decoction, filter, filtrate is concentrated in right amount, adds ethanol and makes and contain alcohol and measure and reach 40-60%, leave standstill, filter, filtrate recycling ethanol to relative density is 1.05-1.10, spray drying, medicated powder and sodium bicarbonate mixing add starch or dextrin, granulate, citric acid or fumaric acid or malic acid are granulated, and mix two parts granule, spray into volatile oil, mixing, tabletting, the infantile diarrhea effervescent tablet gets product.
Above-described a kind of preparation method for the treatment of the medicine of infantile diarrhea is characterized in that finished product infantile diarrhea effervescent tablet contains Radix Puerariae with puerarin C
21H
20O
9Meter is no less than 0.1%.
Finished product of the present invention can be differentiated by the following method:
1, get 10 of this product, porphyrize claims 5g, adds concentrated hydrochloric acid 3ml and chloroform 50ml, and supersound extraction 45 minutes is put coldly, filters, and the filtrate water bath method adds anhydrous alcohol solution to 5ml, as need testing solution.Extracting liquorice subacid standard substance are made into 0.5mg/ml solution with the dehydrated alcohol product in addition, in contrast product solution.Draw above-mentioned 2 solution 20ul points on same gel GF 254 plate, with petroleum ether-benzene-ethyl acetate-glacial acetic acid (10: 20: 7: 0.5) launch, inspect under the ultraviolet light 254nm, in the test sample chromatograph, show identical fluorescence speckle in reference substance chromatograph relevant position.
2, get 10 of this product, porphyrize claims fine powder 5g, adds n-hexane 20ml, and supersound process 20 minutes filters, and filtrate is as need testing solution.Other gets Rhizoma Atractylodis Macrocephalae control medicinal material 1g and shines medical material solution in pairs with legal system.Drawing above-mentioned freshly prepd two kinds of solution 20ul, put respectively on same silica gel G plate, is developing solvent with petroleum ether (60-90 )-ethyl acetate-(50: 1), launches, and takes out, and dries, and sprays 5% vanillin sulfuric acid solution, is heated to clear spot.The test sample chromatograph should have a pink speckle corresponding with the reference substance chromatograph.
Finished product of the present invention can carry out assay by the following method:
Chromatographic condition and coefficient compatibility test: with octadecyl silane is filler; Methanol-water (25: 75) is a mobile phase; The detection wavelength is 250nm, and theoretical cam curve is calculated by puerarin and is not less than 4000.
Reference substance liquid preparation: precision takes by weighing puerarin 10mg, puts in the 25ml volumetric flask, adds 30% ethanol to scale, shakes up, and precision is measured 1ml and put in the 10ml volumetric flask, adds 30% ethanol to scale, shakes up, promptly.
The preparation of test sample liquid: get 5 of this product, porphyrize, precision takes by weighing fine powder 1g, puts in the conical flask, the accurate 30% ethanol 50ml that adds, claim decide weight, supersound extraction 1 hour is put coldly, and weight decided in title again, supplies with 30% ethanol to subtract weight loss, shake up, filter, get subsequent filtrate, promptly.
Algoscopy: accurate respectively reference substance solution and each 10ul of need testing solution of drawing, inject chromatograph of liquid, measure, promptly.This product contains Radix Puerariae with puerarin (C
21H
20O
9) meter, be no less than 0.1%.
Compared with prior art, pharmaceutical dosage form of the present invention adopts effervescent tablet, its dosage form advanced person; Effervescent tablet is a solid preparation, good stability, and easily storage, taking convenience, dosage are accurate; Effervescent tablet effective component content height, curative effect with the inventive method preparation are reliable; Medicine of the present invention does not contain antiseptic and sucrose, is easy to the patient and accepts; Preparation of the present invention is set up content assaying method and new quality standard, makes the quality of the pharmaceutical preparations controlled.Good mouthfeel when effervescent tablet of the present invention is taken, and solution overall appearance sensation is graceful, and similar soda pop is easy to child patient and accepts.Medicine of the present invention is the sepia effervescent tablet; Feeble QI, it is sweet to distinguish the flavor of.Function cures mainly: air making-up and spleen enlivening, stomach function regulating promotes the production of body fluid.Be used for the infantile diarrhea vomiting, flesh heat is thirsty, dyspepsia, the asthenia of becoming thin, pale tongue with white fur.Usage and dosage: oral, child one time is 2 more than 10 years old, and 2 times on the one, child below 10 years old is cut down according to the circumstance.
The specific embodiment
Embodiment 1.A kind of medicine for the treatment of infantile diarrhea, it is the medicament of being made by following weight percentages, described pharmaceutical formulation is an effervescent tablet,
Herbal raw material:
Radix Codonopsis 15% Rhizoma Atractylodis Macrocephalae 20% Poria 20%
Radix Puerariae 24%g Radix Glycyrrhizae 5% Herba Pogostemonis 5%
The Radix Aucklandiae 5%;
Pharmaceutic adjuvant:
Starch 2% sodium bicarbonate 3% citric acid 1%.
Embodiment 2.Embodiment 1 described a kind of preparation method for the treatment of the medicine of infantile diarrhea is got described seven flavor herbal raw materials, and the Rhizoma Atractylodis Macrocephalae, Herba Pogostemonis, the Radix Aucklandiae add the water distillation, extract volatile oil; Medicinal residues and all the other four flavors decoct with water 3 times, and each 2 hours, collecting decoction, filter, filtrate is concentrated in right amount, adds ethanol and makes and contain alcohol and measure and reach 50%, leave standstill, filter, filtrate recycling ethanol to relative density is 1.07, spray drying, medicated powder and sodium bicarbonate mixing add starch, granulate, citric acid is granulated, and mixes two parts granule, sprays into volatile oil, mixing, tabletting, the infantile diarrhea effervescent tablet gets product.
Embodiment 3.A kind of medicine for the treatment of infantile diarrhea, it is the medicament of being made by following weight percentages, described pharmaceutical formulation is an effervescent tablet,
Herbal raw material:
Radix Codonopsis 10% Rhizoma Atractylodis Macrocephalae 25% Poria 15%
Radix Puerariae 20% Radix Glycyrrhizae 7% Herba Pogostemonis 7%
The Radix Aucklandiae 7%;
Pharmaceutic adjuvant:
Dextrin 3% sodium bicarbonate 3% malic acid 3%.
Embodiment 4.A kind of preparation method for the treatment of the medicine of infantile diarrhea of embodiment 3 is got described seven flavor herbal raw materials, and the Rhizoma Atractylodis Macrocephalae, Herba Pogostemonis, the Radix Aucklandiae add the water distillation, extract volatile oil; Medicinal residues and all the other four flavors decoct with water 2 times, and each 3 hours, collecting decoction, filter, filtrate is concentrated in right amount, adds ethanol and makes and contain alcohol and measure and reach 60%, leave standstill, filter, filtrate recycling ethanol to relative density is 1.05, spray drying, medicated powder and sodium bicarbonate mixing add dextrin, granulate, malic acid is granulated, and mixes two parts granule, sprays into volatile oil, mixing, tabletting, the infantile diarrhea effervescent tablet gets product.
Embodiment 5.A kind of medicine for the treatment of infantile diarrhea, it is the medicament of being made by following weight percentages, described pharmaceutical formulation is an effervescent tablet,
Herbal raw material:
Radix Codonopsis 20% Rhizoma Atractylodis Macrocephalae 15% Poria 15%
Radix Puerariae 20% Radix Glycyrrhizae 10% Herba Pogostemonis 5%
The Radix Aucklandiae 5%;
Pharmaceutic adjuvant:
Starch 5% sodium bicarbonate 3% fumaric acid 2%.
Embodiment 6.Embodiment 5 described a kind of preparation methoies for the treatment of the medicine of infantile diarrhea are got described seven flavor herbal raw materials, and the Rhizoma Atractylodis Macrocephalae, Herba Pogostemonis, the Radix Aucklandiae add the water distillation, extract volatile oil; Medicinal residues and all the other four flavors decoct with water 4 times, and each 1 hour, collecting decoction, filter, filtrate is concentrated in right amount, adds ethanol and makes and contain alcohol and measure and reach 40%, leave standstill, filter, filtrate recycling ethanol to relative density is 1.10, spray drying, medicated powder and sodium bicarbonate mixing add starch, granulate, fumaric acid is granulated, and mixes two parts granule, sprays into volatile oil, mixing, tabletting, the infantile diarrhea effervescent tablet gets product.
Embodiment 7.A kind of medicine for the treatment of infantile diarrhea, it is the medicament of being made by following weight percentages, described pharmaceutical formulation is an effervescent tablet,
Herbal raw material:
Radix Codonopsis 18% Rhizoma Atractylodis Macrocephalae 23% Poria 18%
Radix Puerariae 22% Radix Glycyrrhizae 5% Herba Pogostemonis 5%
The Radix Aucklandiae 5%;
Medical accessory:
Dextrin 1% sodium bicarbonate 2% citric acid 1%.
Its preparation method is, gets above seven flavor herbal raw materials, and the Rhizoma Atractylodis Macrocephalae, Herba Pogostemonis, the Radix Aucklandiae add the water distillation, extract volatile oil; Medicinal residues and all the other four flavors decoct with water 3 times, and the 1st, 2 time 3 hours, the 3rd time 2 hours, collecting decoction, filter, filtrate is concentrated in right amount, adds ethanol and makes and contain alcohol and measure and reach 55%, leaves standstill, filter, filtrate recycling ethanol to relative density is 1.08, spray drying, medicated powder and sodium bicarbonate mixing add dextrin, granulate, and citric acid is granulated, mix two parts granule, spray into volatile oil, mixing, tabletting, the infantile diarrhea effervescent tablet that gets product, the finished product infantile diarrhea effervescent tablet of present embodiment contains Radix Puerariae with puerarin C
21H
20O
9Meter is 0.1%.
Claims (4)
1, a kind of medicine for the treatment of infantile diarrhea is characterized in that, it is the medicament of being made by following weight percentages, and described pharmaceutical formulation is an effervescent tablet,
Herbal raw material:
Radix Codonopsis 10-20% Rhizoma Atractylodis Macrocephalae 15-25% Poria 15-25%
Radix Puerariae 20-30% Radix Glycyrrhizae 5-10% Herba Pogostemonis 5-10%
Radix Aucklandiae 5-10%;
Pharmaceutic adjuvant:
Starch or dextrin 1-10% sodium bicarbonate 2-10%
Citric acid or fumaric acid or malic acid 0.5-5%.
2, a kind of medicine for the treatment of infantile diarrhea according to claim 1 is characterized in that, the percentage by weight of each raw material is,
Herbal raw material:
Radix Codonopsis 15% Rhizoma Atractylodis Macrocephalae 20% Poria 20%
Radix Puerariae 24%g Radix Glycyrrhizae 5% Herba Pogostemonis 5%
The Radix Aucklandiae 5%;
Pharmaceutic adjuvant:
Starch or dextrin 2% sodium bicarbonate 3%
Citric acid or fumaric acid or malic acid 1%.
3, claim 1 or 2 described a kind of preparation methoies for the treatment of the medicine of infantile diarrhea is characterized in that, get above seven flavor herbal raw materials, and the Rhizoma Atractylodis Macrocephalae, Herba Pogostemonis, the Radix Aucklandiae add the water distillation, extract volatile oil; Medicinal residues and all the other four flavors decoct with water 2-4 time, and each 1-3 hour, collecting decoction, filter, filtrate is concentrated in right amount, adds ethanol and makes and contain alcohol and measure and reach 40-60%, leave standstill, filter, filtrate recycling ethanol to relative density is 1.05-1.10, spray drying, medicated powder and sodium bicarbonate mixing add starch or dextrin, granulate, citric acid or fumaric acid or malic acid are granulated, and mix two parts granule, spray into volatile oil, mixing, tabletting, the infantile diarrhea effervescent tablet gets product.
4, a kind of preparation method for the treatment of the medicine of infantile diarrhea according to claim 3 is characterized in that, finished product infantile diarrhea effervescent tablet contains Radix Puerariae with puerarin C
21H
20O
9Meter is no less than 0.1%.
Priority Applications (1)
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Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101773573B (en) * | 2009-01-13 | 2011-06-15 | 路晓康 | Chinese medicine composition for treating infantile diarrhea |
CN102988871A (en) * | 2012-12-17 | 2013-03-27 | 凤台县中医院 | Traditional Chinese medicine composition used for treating chronic diarrhea |
CN103494917A (en) * | 2013-09-29 | 2014-01-08 | 刘海峰 | Traditional Chinese medicine for treating enteritis |
CN103520686A (en) * | 2013-10-21 | 2014-01-22 | 邓鑫 | Medicine for curing diarrhea caused by acquired immune deficiency syndrome |
CN104857496A (en) * | 2015-06-19 | 2015-08-26 | 青岛辰达生物科技有限公司 | Traditional Chinese medicine navel paste for treating wind-cold type infantile diarrhea |
CN105395524A (en) * | 2015-12-03 | 2016-03-16 | 孟红琳 | Preparation method of traditional Chinese medicinal rapidly-dissolving film for treating infantile diarrhea |
CN105902611A (en) * | 2016-06-12 | 2016-08-31 | 亳州市沪谯药业有限公司 | Preparation method of kudzuvine root medicinal slices applicable to diarrhea disease of spleen deficiency |
CN109260256A (en) * | 2018-11-26 | 2019-01-25 | 张瑞武 | A kind of baby diarrhea effervescence granular |
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2004
- 2004-02-25 CN CNB2004100141862A patent/CN1322873C/en not_active Expired - Lifetime
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101773573B (en) * | 2009-01-13 | 2011-06-15 | 路晓康 | Chinese medicine composition for treating infantile diarrhea |
CN102988871A (en) * | 2012-12-17 | 2013-03-27 | 凤台县中医院 | Traditional Chinese medicine composition used for treating chronic diarrhea |
CN103494917A (en) * | 2013-09-29 | 2014-01-08 | 刘海峰 | Traditional Chinese medicine for treating enteritis |
CN103520686A (en) * | 2013-10-21 | 2014-01-22 | 邓鑫 | Medicine for curing diarrhea caused by acquired immune deficiency syndrome |
CN103520686B (en) * | 2013-10-21 | 2015-09-09 | 邓鑫 | A kind of medicine for the treatment of acquired immune deficiency syndrome (AIDS) diarrhoea |
CN104857496A (en) * | 2015-06-19 | 2015-08-26 | 青岛辰达生物科技有限公司 | Traditional Chinese medicine navel paste for treating wind-cold type infantile diarrhea |
CN104857496B (en) * | 2015-06-19 | 2016-03-30 | 王玉美 | A kind of Chinese traditional medicine navel for the treatment of children's's wind-cold type diarrhoea pastes |
CN105395524A (en) * | 2015-12-03 | 2016-03-16 | 孟红琳 | Preparation method of traditional Chinese medicinal rapidly-dissolving film for treating infantile diarrhea |
CN105902611A (en) * | 2016-06-12 | 2016-08-31 | 亳州市沪谯药业有限公司 | Preparation method of kudzuvine root medicinal slices applicable to diarrhea disease of spleen deficiency |
CN109260256A (en) * | 2018-11-26 | 2019-01-25 | 张瑞武 | A kind of baby diarrhea effervescence granular |
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