CN104367650A - Blood circulation-promoting and dysentery-stopping preparation for chronic dysentery as well as preparation method thereof - Google Patents
Blood circulation-promoting and dysentery-stopping preparation for chronic dysentery as well as preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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Abstract
The invention discloses a blood circulation-promoting and dysentery-stopping preparation for chronic dysentery as well as a preparation method thereof. The preparation is prepared from the following main raw medicinal materials in parts by weight: 3-6 parts of coptis chinensis, 10-20 parts of roots of Chinese pulsatilla, 5-15 parts of elecampane, 15-25 parts of capitate knotweed herb, 6-12 parts of bischofia javanica, 12-20 parts of astragalus membranaceus, 6-10 parts of angelica sinensis, 8-15 parts of cassia twig, 18-40 parts of purslane, 6-12 parts of ligusticum wallichii, 6-15 parts of thyrocarpus sampsonii and 4-9 parts of lactuca indica. The preparation is remarkable in curative effect, free of toxic and side effects, short in course of treatment, quick in effect and relapse-free.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of chronic dysentery and to invigorate blood circulation dysentery stopping preparation and preparation method thereof.
Background technology
Dysentery is a kind of commonly encountered diseases being main feature with stomachache, tenesmus, dysentery pus and blood, is apt to occur in summer and autumn."Nei Jing" is referred to as " spouting bleeding from anus ", " red fertile ", caused by the heresy how damp and hot by impression, epidemic disease is malicious and eating and drinking without temperance impairing the spleen and stomach intestinal internal organs.The course of disease is called chronic dysentery more than more than two months persons.How to be changed by acute bacillary dysentery, in the majority with good fortune Salmonella the infected.Some courses of disease are several months or several years, and intestinal pathological changes is risen one after another during this period, and original ulcer not yet heals, and new ulcer is formed again.Therefore new and old focus exists simultaneously.Because the injury repairing of tissue is carried out repeatedly, chronic ulcer edge is irregular, the normal hyperplasia of mucosa and form polyp.The each layer of intestinal wall has chronic inflammatory cell infiltration and proliferation of fibrous tissue, and even cicatrization, thus make intestinal wall irregular thickening, hardening, serious case can cause stenosis of bowel.
The treatment of chronic dysentery: 1. general treatment.Form good living habit, avoid psychentonia, note striking a proper balance between work and rest, improve resistance and the adaptive faculty of body.The few slag of feed, nutritious, be easy to the food that digests, avoid cold stimulation, active treatment intestinal parasitical diseases.2. Drug therapy.Effective antibacterials to be selected according to drug sensitive test result or Couple herbs in the past, use in conjunction 2 kinds of antibacterials also extend the period for the treatment of to 10 ~ 15 days, also can the effective antibacterials of alternate application, retention enema can be carried out if desired: enema 200mL, add antibacterials as 0.5% kanamycin, 1% ~ 2% neomycin etc. with 0.25% procaine and 20mg prednisone, every night once, within 10 ~ 14 days, be a course for the treatment of.It is that consolidating YIN expels the heat-evil that the traditional Chinese medical science is thought to the treatment of deficiency of YIN dysentery, righting dysentery relieving.Zhuche pills plus-minus is closed with Chinese goldthread colla corii asini decoction.Damp and hot based on Qinghua during chronic dysentery with frequent relapse outbreak, available Radix Pulsatillae Decoction plus-minus.Based on invigorating the spleen and benefiting QI when stopping, available invigorating the spleen and regulating the stomach soup closes Xianglian Wan.Warming and recuperating the spleen and kidney is answered to deficiency and coldness dysentery, helps admittedly to take off.Subtract with Taohua Tang He Yangzang Tonga.Answer clearing away heat and eliminating dampness to detoxify to dysentery due to damp-heat, be aided with regulating QI promoting the circulation of blood.Clearing away heat,cooling blood and removing toxin is answered to fulminant dysentery.
Publication number CN 1857460 A(application number 2006100050998.1) Chinese patent literature disclose a kind of pharmaceutical composition for the treatment of dysentery, Main Ingredients and Appearance is herb Potentillae cryptotaeniae, Radix ardisiae villosae, Fructus glochidionis puberi(Herba Glochidii Puberi), Herba Chenopodii Hybridi, Folium Bauhiniae pernervosae, Mahonia fortunei (Lindl.) Fedde and Mel.Application publication number CN 104096159 A(application number 201410343777.8) Chinese patent literature disclose the viable bacteria mixture of a kind of relieve chronic dysentery and bowel dysfunction, take off the primary raw material stating weight proportion to be prepared from: Fructus Evodiae 2-4 part, Fructus Gardeniae 3-10 part, Massa Medicata Fermentata 4-12 part, Fructus Schisandrae Chinensis 5-12 part, Poria cum Radix Pini 4-12 part, Fructus Crataegi 6-15 part, Herba Dendrobii 6-9 part, Fructus Amomi 5-12 part, Nodus Nelumbinis Rhizomatis 3-10 part, bacillus cereus 0.3-1.0 part.Application publication number CN 103405703 A(application number 201310275325.6) Chinese patent literature provide a kind of Chinese medicine pill for the treatment of chronic dysentery, comprise following weight ratio thin,tough silk and become Chinese medicine component: Radix Scutellariae 10-15 part, Rhizoma Atractylodis Macrocephalae 12-18 part, 15 parts, Poria, Massa Medicata Fermentata 5 parts, the Radix Aucklandiae 8 parts, Fructus Amomi 10-15 part, Rhizoma Dioscoreae 15-20 part, 10 parts, Flos Sophorae, Radix Platycodonis 5 parts, Cortex Ailanthi difficult to understand 20 parts, Radix Sanguisorbae 10-15 part, Herba Portulacae 20 parts, 6 parts, Radix Glycyrrhizae; Additionally provide the preparation method of pill.
In a word, the chronic bacillary dysentery course of disease is long, recurrent exerbation or protracted course of disease, and clinical in antibiotic therapy at present, bad for chronic dysentery curative effect, toxic and side effects is large.And treatment by Chinese herbs chronic dysentery is longer for the course for the treatment of.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of chronic dysentery and to invigorate blood circulation dysentery stopping preparation and preparation method thereof.Said preparation is evident in efficacy, have no side effect, short treating period, instant effect, without recurrence.
Technical scheme of the present invention is:
Chronic dysentery is invigorated blood circulation dysentery stopping preparation, takes off the primary raw material medicine stating weight proportion and is prepared from: Rhizoma Coptidis 3-6, Radix Pulsatillae 10-20, Radix Aucklandiae 5-15, Herba Polygoni Capitati 15-25, Ramulus et Folium Bischofiae Javanicae 6-12, Radix Astragali 12-20, Radix Angelicae Sinensis 6-10, Ramulus Cinnamomi 8-15, Herba Portulacae 18-40, Rhizoma Chuanxiong 6-12, Radix Thyrocarpi sampsonii 6-15, the blue or green 4-9 of straw sandals.
Chronic dysentery is invigorated blood circulation dysentery stopping preparation, and preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Rhizoma Coptidis 4-5.5, Radix Pulsatillae 13-16, Radix Aucklandiae 8-12, Herba Polygoni Capitati 19-22, Ramulus et Folium Bischofiae Javanicae 8-11, Radix Astragali 15-18, Radix Angelicae Sinensis 7-9, Ramulus Cinnamomi 11-13, Herba Portulacae 24-32, Rhizoma Chuanxiong 9-11, Radix Thyrocarpi sampsonii 8-11, the blue or green 6-8 of straw sandals.
Chronic dysentery is invigorated blood circulation dysentery stopping preparation, and the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: Rhizoma Coptidis 5, the Radix Pulsatillae 14, the Radix Aucklandiae 10, Herba Polygoni Capitati 21, Ramulus et Folium Bischofiae Javanicae 9, the Radix Astragali 17, Radix Angelicae Sinensis 8, Ramulus Cinnamomi 12, Herba Portulacae 29, Rhizoma Chuanxiong 10, Radix Thyrocarpi sampsonii 9, straw sandals green grass or young crops 7.
Present invention also offers the preparation method that dysentery stopping preparation of aforementioned chronic dysentery being invigorated blood circulation makes pharmaceutically acceptable decoction, powder, thick paste agent and pill.
The preparation method of described decoction is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 15-35 minute (being preferably soaked in water 25 minutes), drag in basket, add a cover wet cloth profit 4-8 hour (preferably add a cover wet cloth and moisten 5 hours), take out, section, soak 1.5-3.5 hour (preferably soaking 2.5 hours with wine again) with wine again, take out;
(2) all the other the 10 taste crude drugs except the Radix Pulsatillae and the Radix Aucklandiae are placed in marmite, add water, the consumption of water is 2.5-5.5 times (consumption of preferred water is 4.5 times of the medical material gross weight added) of the medical material gross weight added, and soaks 1.5-2.5 hour (preferably soaking 2 hours);
(3) medical material that step (2) was soaked first is boiled to boiling with big fire, rear turn of little fire decocts 15-30 minute (preferably, a turn little fire decocts 22 minutes), add water, the consumption of water is 2.2-4.5 times (consumption of preferred water is 3.2 times of the medical material gross weight added) of the medical material gross weight added, then add the Radix Aucklandiae and step (1) the gained Radix Pulsatillae, boil to boiling with big fire, rear turn of little fire decocts 35-55 minute (preferably, a turn little fire decocts 42 minutes), leach medicinal liquid, to obtain final product.
The preparation method of described powder is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 15-35 minute (being preferably soaked in water 25 minutes), drags in basket, add a cover wet cloth profit 4-8 hour (preferably add a cover wet cloth and moisten 5 hours), take out, section, then soak 1.5-3.5 hour (preferably soaking 2.5 hours with wine again) with wine, take out, dry, be ground into fine powder, cross 130-170 mesh sieve (preferred mistake 150 mesh sieve);
(2) all the other crude drug except the Radix Pulsatillae are removed impurity, pulverize respectively and grind to form fine powder, cross 140-180 mesh sieve (preferred mistake 150 mesh sieve);
(3) step (1) and step (2) gained fine powder are fully mixed, sterile packaged, often wrap 5 grams.
The preparation method of described thick paste agent is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 15-35 minute (being preferably soaked in water 25 minutes), drag in basket, add a cover wet cloth profit 4-8 hour (preferably add a cover wet cloth and moisten 5 hours), take out, section, soak 1.5-3.5 hour (preferably soaking 2.5 hours with wine again) with wine again, take out;
(2) all the other the 10 taste crude drugs except the Radix Pulsatillae and the Radix Aucklandiae are placed in marmite, add water, the consumption of water is 2.2-5.5 times (consumption of preferred water is 4.5 times of the medical material gross weight added) of the medical material gross weight added, and soaks 1.5-2.5 hour (preferably soaking 2 hours);
(3) medical material that step (2) was soaked first is boiled to boiling with big fire, rear turn of little fire decocts 15-30 minute (preferably, a turn little fire decocts 22 minutes), add water, the consumption of water is 2.2-4.5 times (consumption of preferred water is 3.2 times of the medical material gross weight added) of the medical material gross weight added, then the Radix Aucklandiae and step (1) the gained Radix Pulsatillae is added, boil to boiling with big fire, rear turn of little fire decocts 35-55 minute (preferably, a turn little fire decocts 42 minutes), leaches medicinal liquid;
(4) reduced pressure by step (3) gained medicinal liquid, to be concentrated into relative density be the preferred relative density of 1.2-1.4(is 1.3) clear paste, then add adjuvant and mix well, seal and get final product in dress aseptic bottle.
The preparation method of described pill is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 15-35 minute (being preferably soaked in water 25 minutes), drags in basket, add a cover wet cloth profit 4-8 hour (preferably add a cover wet cloth and moisten 5 hours), take out, section, then soak 1.5-3.5 hour (preferably soaking 2.5 hours with wine again) with wine, take out, dry, be ground into fine powder, cross 110-140 mesh sieve (preferred mistake 130 mesh sieve);
(2) all the other crude drug except the Radix Pulsatillae are removed impurity, after drying, these medicines are mixed together and are ground into fine powder, cross 110-150 mesh sieve (preferred mistake 130 mesh sieve), then fully mix with step (1) gained fine powder;
(3) refined honey is joined in step (2) gained mixing fine powder, the weight of refined honey is 0.9-1.8 times (weight of preferred refined honey is 1.3 times of medicine gross weight) of medicine gross weight, make little pill, the particle diameter of little pill is the particle diameter that 2-5mm(preferably makes little pill is 3mm).
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Rhizoma Coptidis: another name: taste company, Rhizoma Coptidis, Rhizoma Coptidis, base is former: be the dry rhizome of ranunculaceae plant Rhizoma Coptidis, Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall.The property of medicine: bitter, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.
The Radix Pulsatillae: base is former: this product is the dry root of the ranunculaceae plant Radix Pulsatillae.The property of medicine: bitter, cold.Return stomach, large intestine channel.Function cures mainly: heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.For toxic-heat and blood stasis, pudendal pruritus leukorrhagia, amebic dysentery.
The Radix Aucklandiae: base is former: be the dry root of the feverfew Radix Aucklandiae.The property of medicine: pungent, bitter, temperature.Return spleen, stomach, large intestine, three burnt, gallbladder meridians.Function cures mainly: promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.For breast gastral cavity distending pain, heavy after dysentery, food stagnation does not disappear, anorexia.The real intestinal antidiarrheal of Radix Aucklandiae (roasted).For stomachache of having loose bowels.
Herba Polygoni Capitati: base is former: be the herb of polygonaceae plant Herba Polygoni Capitati.Chemical composition of Chinese materia medica: Herba Polygoni Capitati herb contains benzaldehyde, acetic acid, 24-hydroxyl lignocerane-3-ketone, 29-hydroxyl nonacosane-3-ketone, cupreol, gallic acid." Guangxi Chinese herbal medicine ": " bitter in the mouth, pungent, property is put down, nontoxic." function cures mainly: removing toxic substances, dissipating blood stasis, inducing diuresis for treating stranguria syndrome.Control dysentery, pyelitis, cystitis, lithangiuria, rheumatalgia, traumatic injury, skin infection eczema.
Ramulus et Folium Bischofiae Javanicae: base is former: be root, the bark of euphorbia plant Ramulus et Folium Bischofiae Javanicae.Chemical composition of Chinese materia medica: stem is containing cupreol, freidelin, epifriedelanol, freidelin alcohol and cupreol-β-glycoside.Seed oil-containing 25.5%, the iodine number 159.0 of oil, saponification number 194.5.Fatty acid forms: myristic acid 0.3%, Palmic acid 10.5%, stearic acid 5.0%, hexadecenoic acid 0.2%, oleic acid 23.9%, linoleic acid 23.4%, linolenic acid 36.7%.The property of medicine: pungent, puckery, cool.GUIXIN warp.Function cures mainly: expelling wind and removing dampness, blood stasis dispelling removing food stagnancy.Main rheumatic ostalgia, dysphagic, regurgitation, dysentery.
The Radix Astragali: base is former: be the dry root of leguminous plant Radix Astagali or Radix Astragali.The property of medicine: sweet, temperature.Return lung, spleen channel.Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst, chronic nephritis proteinuria, diabetes.
Radix Angelicae Sinensis: base is former: be the dry root of umbelliferae angelica.The property of medicine: sweet, acrid, warm.Return liver, the heart, spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Ramulus Cinnamomi: base is former: be the twig of canella Cortex Cinnamomi.Ramulus Cinnamomi is containing volatile oil 0.69%, and in oil, main component is cinnamic aldehyde 64.75%, also has benzyl benzoate, cinnamyl acetate, β-cadinene, Chang Pu alkene, coumarin etc.The property of medicine: acrid, sweet, warm.Return bladder, the heart, lung meridian.Function cures mainly: expelling cold and relieving exterior syndrome, promoting the flow of QI-blood by warming the meridian.For activating YANG and prormoting functioning of QI exterior syndrome due to wind-cold, arthralgia due to cold-dampnes, extreme cold of the limbs, amenorrhea dysmenorrhea ， mass in the abdomen lumps, the thoracic obstruction, cardiopalmus, phlegm retention, dysuria.
Herba Portulacae: base is former: be the herb of portulacaceous plant Herba Portulacae.Chemical composition of Chinese materia medica: herb is containing a large amount of norepinephrine and volume potassium salt (comprising potassium nitrate, potassium chloride, potassium sulfate and other potassium salt).Also containing DOPA, dopamine, betanidin, isobetanidin, different Radix Betae glycoside, oxalic acid, malic acid, citric acid, glutamic acid, aspartic acid, alanine and glucose, fructose, sucrose etc.Herb shows alkaloid according to another report, coumarin, flavone, the reaction of cardiotonic glycoside and anthracene glycoside.And containing a large amount of poly-omega-3 unsaturated fatty acids.The property of medicine: acid, cold.Return large intestine, Liver Channel.Function cures mainly: heat-clearing and toxic substances removing, cooling blood for hemostasis.For toxic-heat and blood stasis, carbuncle furuncle, eczema, erysipelas, snake bite and insect sting, has blood in stool, hemorrhoidal bleeding, metrostaxis.
Rhizoma Chuanxiong: base is former: be the dry rhizome of samphire Rhizoma Chuanxiong.The property of medicine: pungent, temperature.Return liver, gallbladder, pericardium channel.Function cures mainly: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea ， mass in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Radix Thyrocarpi sampsonii: base is former: be the herb of Boraginaceae Radix Thyrocarpi sampsonii platymiscium Radix Thyrocarpi sampsonii.The property of medicine: bitter, cool.Function cures mainly: clearing heat, releasing toxin, removing swelling.Cure mainly carbuncle, furuncle, have sore throat, have loose bowels, dysentery.
Straw sandals are blue or green: base is former: be the herb of Thelypteridaceae Parathelypteris glanduligera (Kunze) Ching platymiscium Pronephrium simplex.The property of medicine: sweet, micro-puckery, cool.Function cures mainly: heat-clearing and toxic substances removing.Cure mainly laryngopharynx swelling and pain, dysentery, venom.
Chronic dysentery provided by the invention is invigorated blood circulation dysentery stopping preparation scientific formula, and the preparation method of various dosage form is simple, products obtained therefrom taking convenience.In addition, excellent results of the present invention also shows:
1, safe and reliable, have no side effect;
2, short treating period, instant effect;
3, evident in efficacy, without recurrence;
4, there is effect of heat-clearing and toxic substances removing, loosening bowel to relieve constipation, dysentery relieving of invigorating blood circulation;
5, raw material is cheap and easy to get, and treatment cost is low, alleviates patient economy burden.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1chronic dysentery is invigorated blood circulation dysentery stopping preparation, and the primary raw material medicine getting following weight is prepared from: Rhizoma Coptidis 3g, Radix Pulsatillae 10g, Radix Aucklandiae 5g, Herba Polygoni Capitati 15g, Ramulus et Folium Bischofiae Javanicae 6g, Radix Astragali 12g, Radix Angelicae Sinensis 6g, Ramulus Cinnamomi 8g, Herba Portulacae 18g, Rhizoma Chuanxiong 6g, Radix Thyrocarpi sampsonii 6g, the blue or green 4g of straw sandals.
The invigorate blood circulation preparation method of dysentery stopping preparation decoction of chronic dysentery is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 15 minutes, drag in basket, add a cover wet cloth and moisten 4 hours, take out, section, then soak 1.5 hours with wine, take out;
(2) all the other the 10 taste crude drugs except the Radix Pulsatillae and the Radix Aucklandiae are placed in marmite, add water, the consumption of water is 2.5 times of the medical material gross weight added, and soaks 2 hours;
(3) medical material that step (2) was soaked first is boiled to boiling with big fire, rear turn of little fire decocts 15 minutes, add water, the consumption of water is 2.2 times of the medical material gross weight added, then add the Radix Aucklandiae and step (1) the gained Radix Pulsatillae, boil to boiling with big fire, rear turn of little fire decocts 35 minutes, leach medicinal liquid, to obtain final product.
Instructions of taking: every day twice, each 280mL(decoction being taken warmly).
embodiment 2chronic dysentery is invigorated blood circulation dysentery stopping preparation, and the primary raw material medicine getting following weight is prepared from: Rhizoma Coptidis 6g, Radix Pulsatillae 20g, Radix Aucklandiae 15g, Herba Polygoni Capitati 25g, Ramulus et Folium Bischofiae Javanicae 12g, Radix Astragali 20g, Radix Angelicae Sinensis 10g, Ramulus Cinnamomi 15g, Herba Portulacae 40g, Rhizoma Chuanxiong 12g, Radix Thyrocarpi sampsonii 15g, the blue or green 9g of straw sandals.
The invigorate blood circulation preparation method of dysentery stopping preparation powder of chronic dysentery is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 25 minutes, drag in basket, add a cover wet cloth and moisten 5 hours, take out, section, then soak 2.5 hours with wine, take out, dry, be ground into fine powder, cross 150 mesh sieves;
(2) all the other crude drug except the Radix Pulsatillae are removed impurity, pulverize respectively and grind to form fine powder, cross 150 mesh sieves;
(3) step (1) and step (2) gained fine powder are fully mixed, sterile packaged, often wrap 5 grams.
model case one:once XX, man, 46 years old.Chronic dysentery 3 years.Just because unhygienic diet causes acute toxic dysentery, heal through rescue.After 3 months, suffer from dysentery again because drinking and eating raw food, stool day 8-9 time, tenesmus, is just with pus and blood, once takes XIELITING and transfusion etc., and all diseases disappear, but after this slightly diet accidentally namely recur.Over nearly 1 year, dysentery ceaselessly, all over taking Chinese and western drugs, whole existing stool several every day of not being recovered of dysentery, is just with pus and blood, companion's tenesmus, tenesmus, feverish sensation in the palms and soles, excessive thirst, few abdomen continues continuously to have a pain, and happiness is warm presses temperature food, but appetite is very few, waist is aching and limp to be sent out cool, and shallow complexion shades, look asthenia, faint low voice, pale tongue tongue is white, thready and rapid pulse without strength.Take the present embodiment gained chronic dysentery to invigorate blood circulation dysentery stopping preparation powder, every day twice, each 5 grams, boiled water is taken after mixing it with water.Take two days, stool every day 2 times, be slightly shaped, mycopus amount subtracts, and blood almost loses, and the diseases such as stomachache, tenesmus, feverish sensation in the palms and soles all have and alleviate in various degree.Take 4 days, stool every day 1 time, be shaped, just, band blood and stomachache pain in the abdomen lose, and diet increases, and spirit takes a turn for the better, but still has a small amount of mucus in stool, time feel thirsty.After taking 6 days, all diseases disappear, and sick announcement is fully recovered.Follow up a case by regular visits to and do not recur.
embodiment 3chronic dysentery is invigorated blood circulation dysentery stopping preparation, and the primary raw material medicine getting following weight is prepared from: Rhizoma Coptidis 4g, Radix Pulsatillae 13g, Radix Aucklandiae 8g, Herba Polygoni Capitati 19g, Ramulus et Folium Bischofiae Javanicae 8g, Radix Astragali 15g, Radix Angelicae Sinensis 7g, Ramulus Cinnamomi 11g, Herba Portulacae 24g, Rhizoma Chuanxiong 9g, Radix Thyrocarpi sampsonii 8g, the blue or green 6g of straw sandals.
The invigorate blood circulation thick paste agent preparation method of dysentery stopping preparation of chronic dysentery is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 25 minutes, drag in basket, add a cover wet cloth and moisten 5 hours, take out, section, then soak 2.5 hours with wine, take out;
(2) all the other the 10 taste crude drugs except the Radix Pulsatillae and the Radix Aucklandiae are placed in marmite, add water, the consumption of water is 4.5 times of the medical material gross weight added, and soaks 2 hours;
(3) medical material that step (2) was soaked first is boiled to boiling with big fire, rear turn of little fire decocts 22 minutes, add water, the consumption of water is 3.2 times of the medical material gross weight added, then the Radix Aucklandiae and step (1) the gained Radix Pulsatillae is added, boil to boiling with big fire, rear turn of little fire decocts 42 minutes, leaches medicinal liquid;
(4) step (3) gained medicinal liquid is reduced pressure, be concentrated into the clear paste that relative density is 1.3, then add adjuvant and mix well, seal and get final product in dress aseptic bottle.
model case two:high XX, female, 40 years old.Suffer from dysentery 2 years, take Western medicine, Chinese patent medicine and Chinese medicine decoction and fail eventually more.Existing every day Mucous Stool 5-7 time, be just with pus and blood, few abdominal part dull pain, happiness Wen Xinuan, meet abdominal pain due to cold dysentery weight, tenesmus, stool is smooth, and awareness of defecation is most, bitter taste, red tongue, yellow and greasy fur, soft and rapid pulse.Take the present embodiment gained chronic dysentery to invigorate blood circulation the agent of dysentery stopping preparation thick paste, every day three times, each 25 grams.Take medicine 2 days, stool every day 3 times, shapeless, mucus reduces, and blood almost loses, and symptom alleviates, and body of the tongue is slightly red, yellow and thin fur, still feels slightly cool in abdomen.Take 4 days, stool is shaped substantially, and mucus almost loses, and appetite increases, and all diseases disappear substantially.Take 6 days, recovery from illness.Follow up a case by regular visits to and have no recurrence.
embodiment 4chronic dysentery is invigorated blood circulation dysentery stopping preparation, and the primary raw material medicine getting following weight is prepared from: Rhizoma Coptidis 5.5g, Radix Pulsatillae 16g, Radix Aucklandiae 12g, Herba Polygoni Capitati 22g, Ramulus et Folium Bischofiae Javanicae 11g, Radix Astragali 18g, Radix Angelicae Sinensis 9g, Ramulus Cinnamomi 13g, Herba Portulacae 32g, Rhizoma Chuanxiong 11g, Radix Thyrocarpi sampsonii 11g, the blue or green 8g of straw sandals.
The invigorate blood circulation preparation method of dysentery stopping preparation pill of chronic dysentery is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 25 minutes, drag in basket, add a cover wet cloth and moisten 5 hours, take out, section, then soak 2.5 hours with wine, take out, dry, be ground into fine powder, cross 130 mesh sieves;
(2) all the other crude drug except the Radix Pulsatillae are removed impurity, after drying, these medicines are mixed together and are ground into fine powder, cross 130 mesh sieves, then fully mix with step (1) gained fine powder;
(3) joined by refined honey in step (2) gained mixing fine powder, the weight of refined honey is 1.3 times of medicine gross weight, makes little pill, and the particle diameter of little pill is 3mm.
model case three:woods XX, female, 60 years old.First visit on April 25 in 2009.Suffer from more than dysentery June, more than under dysentery, lower mucoid stool, the band blood streak, companion's tenesmus, xerostomia is weak, red tongue, yellow and thin fur, thready and rapid pulse.Once with the treatments such as intravenous drip Ceftriaxone, amikacin many days, the first used time take a favorable turn, after gradually invalid, defecate still under day dysentery for several times.Take the present embodiment gained chronic dysentery to invigorate blood circulation dysentery stopping preparation pill, every day three times, each 15.Be used in conjunction 4 days, sick announcement is fully recovered.The blood streak loses.Follow up a case by regular visits to 2 years, disease is not sent out again.
embodiment 5chronic dysentery is invigorated blood circulation dysentery stopping preparation, and the primary raw material medicine getting following weight is prepared from: Rhizoma Coptidis 5g, Radix Pulsatillae 14g, Radix Aucklandiae 10g, Herba Polygoni Capitati 21g, Ramulus et Folium Bischofiae Javanicae 9g, Radix Astragali 17g, Radix Angelicae Sinensis 8g, Ramulus Cinnamomi 12g, Herba Portulacae 29g, Rhizoma Chuanxiong 10g, Radix Thyrocarpi sampsonii 9g, the blue or green 7g of straw sandals.
The invigorate blood circulation preparation method of dysentery stopping preparation decoction of chronic dysentery is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 25 minutes, drag in basket, add a cover wet cloth and moisten 5 hours, take out, section, then soak 2.5 hours with wine, take out;
(2) all the other the 10 taste crude drugs except the Radix Pulsatillae and the Radix Aucklandiae are placed in marmite, add water, the consumption of water is 4.5 times of the medical material gross weight added, and soaks 2 hours;
(3) medical material that step (2) was soaked first is boiled to boiling with big fire, rear turn of little fire decocts 22 minutes, add water, the consumption of water is 3.2 times of the medical material gross weight added, then add the Radix Aucklandiae and step (1) the gained Radix Pulsatillae, boil to boiling with big fire, rear turn of little fire decocts 42 minutes, leach medicinal liquid, to obtain final product.
test example 1:in order to verify that embodiment 5 gained chronic dysentery is invigorated blood circulation the drug effect of dysentery stopping preparation, We conducted contrast test.Experiment screening chronic dysentery patient 248 people, is divided into matched group and experimental group randomly, and every panel size is identical, is respectively 124 people.Experimental group: take embodiment 5 gained chronic dysentery and to invigorate blood circulation dysentery stopping preparation decoction, instructions of taking: every day twice, each 280mL(decoction being taken warmly).Matched group: the medicine using the conventional therapy chronic dysenterys such as norfloxacin, bactrim, Berberine Tablet.Curative effect situation criterion: cure: clinical symptoms, sign disappear, and the lab testing such as stool routine examination, routine blood test is often all become a full member; Effective: clinical symptoms, sign disappear substantially, the index such as routine blood test, stool routine examination major part is normal; Take a turn for the better: clinical symptoms, sign take a turn for the better, and routine blood test, stool routine examination part are normal; Invalid: clinical symptoms and sign, blood and stool routine examination check without improving.Result is as shown in the table:
Table 1: embodiment 5 gained chronic dysentery is invigorated blood circulation dysentery stopping preparation decoction compliance test result
Therapeutic effect: cure 76 examples (61.29%), effective 45 examples (36.29%), 3 examples that take a turn for the better (2.42%), total effective rate 97.58%.Successful is better than matched group.
The present invention selects Rhizoma Coptidis, the Radix Pulsatillae, the Radix Aucklandiae, Herba Polygoni Capitati etc. to carry out compatibility, makes these medicines produce synergism, more effectively can treat chronic dysentery.Radix Pulsatillae heat-clearing and toxic substances removing in side, eliminating pathogenic heat from blood to cure dysentery.Rhizoma Coptidis bitter cold has the effect of heat clearing and damp drying, consolidating YIN eliminating fire and detoxication.Radix Aucklandiae promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.Herba Polygoni Capitati detoxifies, dissipating blood stasis, inducing diuresis for treating stranguria syndrome.Ramulus et Folium Bischofiae Javanicae expelling wind and removing dampness, blood stasis dispelling removing food stagnancy.Radix Astragali invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Chinese angelica blood supplementing is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Ramulus Cinnamomi expelling cold and relieving exterior syndrome, promoting the flow of QI-blood by warming the meridian.Herba Portulacae heat-clearing and toxic substances removing, cooling blood for hemostasis.Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping.Radix Thyrocarpi sampsonii clearing heat, releasing toxin, removing swelling.The blue or green heat-clearing and toxic substances removing of straw sandals.All medicine compatibilities, play the effect of heat-clearing and toxic substances removing, loosening bowel to relieve constipation, dysentery relieving of invigorating blood circulation altogether.Chronic dysentery of the present invention dysentery stopping preparation of invigorating blood circulation is evident in efficacy.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. chronic dysentery is invigorated blood circulation dysentery stopping preparation, it is characterized in that, takes off the primary raw material medicine stating weight proportion and be prepared from: Rhizoma Coptidis 3-6, Radix Pulsatillae 10-20, Radix Aucklandiae 5-15, Herba Polygoni Capitati 15-25, Ramulus et Folium Bischofiae Javanicae 6-12, Radix Astragali 12-20, Radix Angelicae Sinensis 6-10, Ramulus Cinnamomi 8-15, Herba Portulacae 18-40, Rhizoma Chuanxiong 6-12, Radix Thyrocarpi sampsonii 6-15, the blue or green 4-9 of straw sandals.
2. chronic dysentery is invigorated blood circulation dysentery stopping preparation, it is characterized in that, takes off the primary raw material medicine stating weight proportion and be prepared from: Rhizoma Coptidis 4-5.5, Radix Pulsatillae 13-16, Radix Aucklandiae 8-12, Herba Polygoni Capitati 19-22, Ramulus et Folium Bischofiae Javanicae 8-11, Radix Astragali 15-18, Radix Angelicae Sinensis 7-9, Ramulus Cinnamomi 11-13, Herba Portulacae 24-32, Rhizoma Chuanxiong 9-11, Radix Thyrocarpi sampsonii 8-11, the blue or green 6-8 of straw sandals.
3. chronic dysentery is invigorated blood circulation dysentery stopping preparation, it is characterized in that, takes off the primary raw material medicine stating weight proportion and be prepared from: Rhizoma Coptidis 5, the Radix Pulsatillae 14, the Radix Aucklandiae 10, Herba Polygoni Capitati 21, Ramulus et Folium Bischofiae Javanicae 9, the Radix Astragali 17, Radix Angelicae Sinensis 8, Ramulus Cinnamomi 12, Herba Portulacae 29, Rhizoma Chuanxiong 10, Radix Thyrocarpi sampsonii 9, straw sandals green grass or young crops 7.
4. to invigorate blood circulation dysentery stopping preparation according to the arbitrary described chronic dysentery of claim 1-3, it is characterized in that, dysentery stopping preparation of this chronic dysentery being invigorated blood circulation makes pharmaceutically acceptable decoction, powder, thick paste agent and pill.
5. chronic dysentery according to claim 4 is invigorated blood circulation the preparation method of dysentery stopping preparation, and it is characterized in that, the preparation method of described decoction is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 15-35 minute (being preferably soaked in water 25 minutes), drag in basket, add a cover wet cloth profit 4-8 hour (preferably add a cover wet cloth and moisten 5 hours), take out, section, soak 1.5-3.5 hour (preferably soaking 2.5 hours with wine again) with wine again, take out;
(2) all the other the 10 taste crude drugs except the Radix Pulsatillae and the Radix Aucklandiae are placed in marmite, add water, the consumption of water is 2.5-5.5 times (consumption of preferred water is 4.5 times of the medical material gross weight added) of the medical material gross weight added, and soaks 1.5-2.5 hour (preferably soaking 2 hours);
(3) medical material that step (2) was soaked first is boiled to boiling with big fire, rear turn of little fire decocts 15-30 minute (preferably, a turn little fire decocts 22 minutes), add water, the consumption of water is 2.2-4.5 times (consumption of preferred water is 3.2 times of the medical material gross weight added) of the medical material gross weight added, then add the Radix Aucklandiae and step (1) the gained Radix Pulsatillae, boil to boiling with big fire, rear turn of little fire decocts 35-55 minute (preferably, a turn little fire decocts 42 minutes), leach medicinal liquid, to obtain final product.
6. chronic dysentery according to claim 4 is invigorated blood circulation the preparation method of dysentery stopping preparation, and it is characterized in that, the preparation method of described powder is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 15-35 minute (being preferably soaked in water 25 minutes), drags in basket, add a cover wet cloth profit 4-8 hour (preferably add a cover wet cloth and moisten 5 hours), take out, section, then soak 1.5-3.5 hour (preferably soaking 2.5 hours with wine again) with wine, take out, dry, be ground into fine powder, cross 130-170 mesh sieve (preferred mistake 150 mesh sieve);
(2) all the other crude drug except the Radix Pulsatillae are removed impurity, pulverize respectively and grind to form fine powder, cross 140-180 mesh sieve (preferred mistake 150 mesh sieve);
(3) step (1) and step (2) gained fine powder are fully mixed, sterile packaged, often wrap 5 grams.
7. chronic dysentery according to claim 4 is invigorated blood circulation the preparation method of dysentery stopping preparation, and it is characterized in that, the preparation method of described thick paste agent is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 15-35 minute (being preferably soaked in water 25 minutes), drag in basket, add a cover wet cloth profit 4-8 hour (preferably add a cover wet cloth and moisten 5 hours), take out, section, soak 1.5-3.5 hour (preferably soaking 2.5 hours with wine again) with wine again, take out;
(2) all the other the 10 taste crude drugs except the Radix Pulsatillae and the Radix Aucklandiae are placed in marmite, add water, the consumption of water is 2.2-5.5 times (consumption of preferred water is 4.5 times of the medical material gross weight added) of the medical material gross weight added, and soaks 1.5-2.5 hour (preferably soaking 2 hours);
(3) medical material that step (2) was soaked first is boiled to boiling with big fire, rear turn of little fire decocts 15-30 minute (preferably, a turn little fire decocts 22 minutes), add water, the consumption of water is 2.2-4.5 times (consumption of preferred water is 3.2 times of the medical material gross weight added) of the medical material gross weight added, then the Radix Aucklandiae and step (1) the gained Radix Pulsatillae is added, boil to boiling with big fire, rear turn of little fire decocts 35-55 minute (preferably, a turn little fire decocts 42 minutes), leaches medicinal liquid;
(4) reduced pressure by step (3) gained medicinal liquid, to be concentrated into relative density be the preferred relative density of 1.2-1.4(is 1.3) clear paste, then add adjuvant and mix well, seal and get final product in dress aseptic bottle.
8. chronic dysentery according to claim 4 is invigorated blood circulation the preparation method of dysentery stopping preparation, and it is characterized in that, the preparation method of described pill is:
(1) Radix Pulsatillae is removed impurity, clean dust, be soaked in water 15-35 minute (being preferably soaked in water 25 minutes), drags in basket, add a cover wet cloth profit 4-8 hour (preferably add a cover wet cloth and moisten 5 hours), take out, section, then soak 1.5-3.5 hour (preferably soaking 2.5 hours with wine again) with wine, take out, dry, be ground into fine powder, cross 110-140 mesh sieve (preferred mistake 130 mesh sieve);
(2) all the other crude drug except the Radix Pulsatillae are removed impurity, after drying, these medicines are mixed together and are ground into fine powder, cross 110-150 mesh sieve (preferred mistake 130 mesh sieve), then fully mix with step (1) gained fine powder;
(3) joined by refined honey in step (2) gained mixing fine powder, the weight of refined honey is 0.9-1.8 times (weight of preferred refined honey is 1.3 times of medicine gross weight) of medicine gross weight, makes little pill.
9. chronic dysentery according to claim 8 is invigorated blood circulation the preparation method of dysentery stopping preparation pill, it is characterized in that, crosses 110-150 mesh sieve (preferred mistake 130 mesh sieve) in step (2).
10. chronic dysentery according to claim 8 is invigorated blood circulation the preparation method of dysentery stopping preparation pill, it is characterized in that, the particle diameter of step (3) medium and small pill is the particle diameter of the preferred little pill of 2-5mm(is 3mm).
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610095590.XA CN105687362A (en) | 2014-10-28 | 2014-10-28 | Blood-activating dysentery-relieving pill for treating chronic dysentery |
| CN201410583037.1A CN104367650A (en) | 2014-10-28 | 2014-10-28 | Blood circulation-promoting and dysentery-stopping preparation for chronic dysentery as well as preparation method thereof |
| CN201610095587.8A CN105560430A (en) | 2014-10-28 | 2014-10-28 | Blood activating and dysentery stopping preparation for treating chronic dysentery |
| CN201610095588.2A CN105616576A (en) | 2014-10-28 | 2014-10-28 | Blood-activating and dysentery-stopping thick paste for chronic dysentery |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410583037.1A CN104367650A (en) | 2014-10-28 | 2014-10-28 | Blood circulation-promoting and dysentery-stopping preparation for chronic dysentery as well as preparation method thereof |
Related Child Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610095588.2A Division CN105616576A (en) | 2014-10-28 | 2014-10-28 | Blood-activating and dysentery-stopping thick paste for chronic dysentery |
| CN201610095587.8A Division CN105560430A (en) | 2014-10-28 | 2014-10-28 | Blood activating and dysentery stopping preparation for treating chronic dysentery |
| CN201610095590.XA Division CN105687362A (en) | 2014-10-28 | 2014-10-28 | Blood-activating dysentery-relieving pill for treating chronic dysentery |
| CN201610095589.7A Division CN105641097A (en) | 2014-10-28 | 2014-10-28 | Blood circulation promoting and dysentery stopping powder for treating chronic dysentery |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104367650A true CN104367650A (en) | 2015-02-25 |
Family
ID=52547011
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610095590.XA Withdrawn CN105687362A (en) | 2014-10-28 | 2014-10-28 | Blood-activating dysentery-relieving pill for treating chronic dysentery |
| CN201610095587.8A Withdrawn CN105560430A (en) | 2014-10-28 | 2014-10-28 | Blood activating and dysentery stopping preparation for treating chronic dysentery |
| CN201610095588.2A Withdrawn CN105616576A (en) | 2014-10-28 | 2014-10-28 | Blood-activating and dysentery-stopping thick paste for chronic dysentery |
| CN201410583037.1A Pending CN104367650A (en) | 2014-10-28 | 2014-10-28 | Blood circulation-promoting and dysentery-stopping preparation for chronic dysentery as well as preparation method thereof |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610095590.XA Withdrawn CN105687362A (en) | 2014-10-28 | 2014-10-28 | Blood-activating dysentery-relieving pill for treating chronic dysentery |
| CN201610095587.8A Withdrawn CN105560430A (en) | 2014-10-28 | 2014-10-28 | Blood activating and dysentery stopping preparation for treating chronic dysentery |
| CN201610095588.2A Withdrawn CN105616576A (en) | 2014-10-28 | 2014-10-28 | Blood-activating and dysentery-stopping thick paste for chronic dysentery |
Country Status (1)
| Country | Link |
|---|---|
| CN (4) | CN105687362A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017020861A1 (en) * | 2015-08-05 | 2017-02-09 | 浙江众康药业有限公司 | Application of polygonum capitatum composition in resisting helicobacter pylori |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040970A (en) * | 2012-12-23 | 2013-04-17 | 徐化利 | Traditional Chinese medicine for treating dysentery |
-
2014
- 2014-10-28 CN CN201610095590.XA patent/CN105687362A/en not_active Withdrawn
- 2014-10-28 CN CN201610095587.8A patent/CN105560430A/en not_active Withdrawn
- 2014-10-28 CN CN201610095588.2A patent/CN105616576A/en not_active Withdrawn
- 2014-10-28 CN CN201410583037.1A patent/CN104367650A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040970A (en) * | 2012-12-23 | 2013-04-17 | 徐化利 | Traditional Chinese medicine for treating dysentery |
Non-Patent Citations (1)
| Title |
|---|
| 杨淑华: "痢疾的中医治疗", 《中外健康文摘》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017020861A1 (en) * | 2015-08-05 | 2017-02-09 | 浙江众康药业有限公司 | Application of polygonum capitatum composition in resisting helicobacter pylori |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105616576A (en) | 2016-06-01 |
| CN105560430A (en) | 2016-05-11 |
| CN105687362A (en) | 2016-06-22 |
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