CN104645061A - Medicine for treating blood stasis stationary chronic gastric ulcer and preparation method - Google Patents
Medicine for treating blood stasis stationary chronic gastric ulcer and preparation method Download PDFInfo
- Publication number
- CN104645061A CN104645061A CN201510123877.4A CN201510123877A CN104645061A CN 104645061 A CN104645061 A CN 104645061A CN 201510123877 A CN201510123877 A CN 201510123877A CN 104645061 A CN104645061 A CN 104645061A
- Authority
- CN
- China
- Prior art keywords
- parts
- herba
- radix
- medicine
- rhizoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 79
- 210000004369 blood Anatomy 0.000 title claims abstract description 57
- 239000008280 blood Substances 0.000 title claims abstract description 57
- 208000007107 Stomach Ulcer Diseases 0.000 title claims abstract description 34
- 201000005917 gastric ulcer Diseases 0.000 title claims abstract description 34
- 230000001684 chronic effect Effects 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 229940079593 drug Drugs 0.000 title description 12
- 235000008100 Ginkgo biloba Nutrition 0.000 claims abstract description 23
- 229920002472 Starch Polymers 0.000 claims abstract description 23
- 244000207032 American speedwell Species 0.000 claims abstract description 22
- 235000011201 Ginkgo Nutrition 0.000 claims abstract description 22
- 241001165578 Hylotelephium verticillatum Species 0.000 claims abstract description 20
- 239000008107 starch Substances 0.000 claims abstract description 5
- 235000019698 starch Nutrition 0.000 claims abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 38
- 239000008187 granular material Substances 0.000 claims description 25
- 241001279228 Campylotropis hirtella Species 0.000 claims description 21
- 241000612122 Myrsine Species 0.000 claims description 21
- 239000000843 powder Substances 0.000 claims description 21
- 241000903946 Clematidis Species 0.000 claims description 19
- 239000000463 material Substances 0.000 claims description 19
- 210000000582 semen Anatomy 0.000 claims description 19
- 235000019890 Amylum Nutrition 0.000 claims description 18
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 15
- 239000006187 pill Substances 0.000 claims description 13
- 239000006071 cream Substances 0.000 claims description 12
- 239000000284 extract Substances 0.000 claims description 12
- 235000012907 honey Nutrition 0.000 claims description 10
- 238000007670 refining Methods 0.000 claims description 10
- 238000010992 reflux Methods 0.000 claims description 9
- 239000002552 dosage form Substances 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 6
- 238000000605 extraction Methods 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 6
- 238000005325 percolation Methods 0.000 claims description 6
- 238000000108 ultra-filtration Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 4
- 239000012567 medical material Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 229920001353 Dextrin Polymers 0.000 claims description 3
- 239000004375 Dextrin Substances 0.000 claims description 3
- 206010013786 Dry skin Diseases 0.000 claims description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 3
- 229930006000 Sucrose Natural products 0.000 claims description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
- 238000009835 boiling Methods 0.000 claims description 3
- 238000002425 crystallisation Methods 0.000 claims description 3
- 230000008025 crystallization Effects 0.000 claims description 3
- 235000019425 dextrin Nutrition 0.000 claims description 3
- 238000004821 distillation Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000008101 lactose Substances 0.000 claims description 3
- 235000019359 magnesium stearate Nutrition 0.000 claims description 3
- 239000013521 mastic Substances 0.000 claims description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 3
- 235000011837 pasties Nutrition 0.000 claims description 3
- 239000002893 slag Substances 0.000 claims description 3
- 238000002791 soaking Methods 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims description 3
- 229960004793 sucrose Drugs 0.000 claims description 3
- 230000008719 thickening Effects 0.000 claims description 3
- 241000218628 Ginkgo Species 0.000 claims 7
- 208000002193 Pain Diseases 0.000 abstract description 36
- 230000001737 promoting effect Effects 0.000 abstract description 28
- 210000000952 spleen Anatomy 0.000 abstract description 24
- 210000002784 stomach Anatomy 0.000 abstract description 24
- 244000194101 Ginkgo biloba Species 0.000 abstract description 17
- 230000000694 effects Effects 0.000 abstract description 8
- 206010061218 Inflammation Diseases 0.000 abstract description 5
- 230000004054 inflammatory process Effects 0.000 abstract description 5
- 230000036039 immunity Effects 0.000 abstract description 4
- 230000001976 improved effect Effects 0.000 abstract description 4
- 230000008901 benefit Effects 0.000 abstract description 3
- 231100000419 toxicity Toxicity 0.000 abstract description 3
- 230000001988 toxicity Effects 0.000 abstract description 3
- 241000122904 Mucuna Species 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- MUKYLHIZBOASDM-UHFFFAOYSA-N 2-[carbamimidoyl(methyl)amino]acetic acid 2,3,4,5,6-pentahydroxyhexanoic acid Chemical compound NC(=N)N(C)CC(O)=O.OCC(O)C(O)C(O)C(O)C(O)=O MUKYLHIZBOASDM-UHFFFAOYSA-N 0.000 abstract 1
- 241000173529 Aconitum napellus Species 0.000 abstract 1
- 235000003276 Apios tuberosa Nutrition 0.000 abstract 1
- 244000105624 Arachis hypogaea Species 0.000 abstract 1
- 235000010777 Arachis hypogaea Nutrition 0.000 abstract 1
- 235000010744 Arachis villosulicarpa Nutrition 0.000 abstract 1
- 241000977338 Aralia undulata Species 0.000 abstract 1
- 241001233914 Chelidonium majus Species 0.000 abstract 1
- 241000218158 Clematis Species 0.000 abstract 1
- 235000002722 Dioscorea batatas Nutrition 0.000 abstract 1
- 235000006536 Dioscorea esculenta Nutrition 0.000 abstract 1
- 240000001811 Dioscorea oppositifolia Species 0.000 abstract 1
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 abstract 1
- 241000501743 Gentiana macrophylla Species 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 241000608174 Gymnadenia Species 0.000 abstract 1
- 235000013717 Houttuynia Nutrition 0.000 abstract 1
- 240000000691 Houttuynia cordata Species 0.000 abstract 1
- 241001252483 Kalimeris Species 0.000 abstract 1
- 241001149105 Limonium sinense Species 0.000 abstract 1
- 244000274911 Myrica cerifera Species 0.000 abstract 1
- 235000009134 Myrica cerifera Nutrition 0.000 abstract 1
- 241000721490 Peperomia Species 0.000 abstract 1
- 244000292697 Polygonum aviculare Species 0.000 abstract 1
- 235000006386 Polygonum aviculare Nutrition 0.000 abstract 1
- 244000040442 Renanthera coccinea Species 0.000 abstract 1
- 240000006322 Sambucus chinensis Species 0.000 abstract 1
- 235000010426 Sambucus chinensis Nutrition 0.000 abstract 1
- 240000001949 Taraxacum officinale Species 0.000 abstract 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 abstract 1
- 241001106462 Ulmus Species 0.000 abstract 1
- 241000159213 Zygophyllaceae Species 0.000 abstract 1
- 230000003467 diminishing effect Effects 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
- 235000009165 saligot Nutrition 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 description 22
- 238000011084 recovery Methods 0.000 description 18
- 206010011224 Cough Diseases 0.000 description 16
- 230000017531 blood circulation Effects 0.000 description 16
- 235000009508 confectionery Nutrition 0.000 description 14
- 241000699670 Mus sp. Species 0.000 description 13
- 210000003734 kidney Anatomy 0.000 description 13
- 210000004185 liver Anatomy 0.000 description 13
- 231100000614 poison Toxicity 0.000 description 13
- 239000003440 toxic substance Substances 0.000 description 13
- 208000025865 Ulcer Diseases 0.000 description 12
- 231100000397 ulcer Toxicity 0.000 description 12
- 206010000087 Abdominal pain upper Diseases 0.000 description 9
- 230000003203 everyday effect Effects 0.000 description 9
- 208000014674 injury Diseases 0.000 description 9
- 230000008736 traumatic injury Effects 0.000 description 9
- 208000006820 Arthralgia Diseases 0.000 description 7
- 206010030113 Oedema Diseases 0.000 description 7
- 210000001124 body fluid Anatomy 0.000 description 7
- 239000010839 body fluid Substances 0.000 description 7
- 230000037396 body weight Effects 0.000 description 7
- 230000007812 deficiency Effects 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 230000007774 longterm Effects 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 230000035922 thirst Effects 0.000 description 7
- 208000004998 Abdominal Pain Diseases 0.000 description 6
- 206010007247 Carbuncle Diseases 0.000 description 6
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 6
- 208000006673 asthma Diseases 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000001848 dysentery Diseases 0.000 description 6
- 230000003014 reinforcing effect Effects 0.000 description 6
- 230000008961 swelling Effects 0.000 description 6
- 206010012735 Diarrhoea Diseases 0.000 description 5
- 208000004880 Polyuria Diseases 0.000 description 5
- 230000003110 anti-inflammatory effect Effects 0.000 description 5
- 230000035619 diuresis Effects 0.000 description 5
- 238000002651 drug therapy Methods 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 201000000736 Amenorrhea Diseases 0.000 description 4
- 206010001928 Amenorrhoea Diseases 0.000 description 4
- 201000004624 Dermatitis Diseases 0.000 description 4
- 208000005171 Dysmenorrhea Diseases 0.000 description 4
- 206010013935 Dysmenorrhoea Diseases 0.000 description 4
- 208000006877 Insect Bites and Stings Diseases 0.000 description 4
- 206010037660 Pyrexia Diseases 0.000 description 4
- 208000025747 Rheumatic disease Diseases 0.000 description 4
- 206010047700 Vomiting Diseases 0.000 description 4
- 210000001015 abdomen Anatomy 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 231100000540 amenorrhea Toxicity 0.000 description 4
- 230000000202 analgesic effect Effects 0.000 description 4
- 230000001939 inductive effect Effects 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
- 210000000056 organ Anatomy 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 238000010791 quenching Methods 0.000 description 4
- 230000000552 rheumatic effect Effects 0.000 description 4
- 206010010774 Constipation Diseases 0.000 description 3
- 208000004232 Enteritis Diseases 0.000 description 3
- 208000034507 Haematemesis Diseases 0.000 description 3
- 208000015817 Infant Nutrition disease Diseases 0.000 description 3
- 206010023126 Jaundice Diseases 0.000 description 3
- 208000005647 Mumps Diseases 0.000 description 3
- 208000008469 Peptic Ulcer Diseases 0.000 description 3
- 206010067171 Regurgitation Diseases 0.000 description 3
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 3
- 208000004078 Snake Bites Diseases 0.000 description 3
- 206010053615 Thermal burn Diseases 0.000 description 3
- 230000029087 digestion Effects 0.000 description 3
- 238000001647 drug administration Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000003304 gavage Methods 0.000 description 3
- 208000035861 hematochezia Diseases 0.000 description 3
- 208000006454 hepatitis Diseases 0.000 description 3
- 206010022437 insomnia Diseases 0.000 description 3
- 230000000968 intestinal effect Effects 0.000 description 3
- 235000012054 meals Nutrition 0.000 description 3
- 230000005906 menstruation Effects 0.000 description 3
- 208000010805 mumps infectious disease Diseases 0.000 description 3
- 208000011906 peptic ulcer disease Diseases 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 210000002435 tendon Anatomy 0.000 description 3
- 210000001835 viscera Anatomy 0.000 description 3
- 230000008673 vomiting Effects 0.000 description 3
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 description 2
- 241000208340 Araliaceae Species 0.000 description 2
- 208000008035 Back Pain Diseases 0.000 description 2
- 241000345998 Calamus manan Species 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 2
- 206010017553 Furuncle Diseases 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 208000008930 Low Back Pain Diseases 0.000 description 2
- 206010027514 Metrorrhagia Diseases 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 206010028813 Nausea Diseases 0.000 description 2
- 208000001431 Psychomotor Agitation Diseases 0.000 description 2
- 241000218201 Ranunculaceae Species 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 208000032023 Signs and Symptoms Diseases 0.000 description 2
- 208000005392 Spasm Diseases 0.000 description 2
- 208000033809 Suppuration Diseases 0.000 description 2
- 206010043458 Thirst Diseases 0.000 description 2
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 2
- 238000011047 acute toxicity test Methods 0.000 description 2
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 2
- 229960003022 amoxicillin Drugs 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 206010003549 asthenia Diseases 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 230000006399 behavior Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 208000019902 chronic diarrheal disease Diseases 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 230000013872 defecation Effects 0.000 description 2
- 230000006735 deficit Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 210000000232 gallbladder Anatomy 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 238000002575 gastroscopy Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 231100000283 hepatitis Toxicity 0.000 description 2
- 210000003026 hypopharynx Anatomy 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 230000003908 liver function Effects 0.000 description 2
- 231100001252 long-term toxicity Toxicity 0.000 description 2
- 201000003453 lung abscess Diseases 0.000 description 2
- 208000004396 mastitis Diseases 0.000 description 2
- 230000003340 mental effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 230000008693 nausea Effects 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 231100000862 numbness Toxicity 0.000 description 2
- 229960000381 omeprazole Drugs 0.000 description 2
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 208000037920 primary disease Diseases 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 210000001187 pylorus Anatomy 0.000 description 2
- 235000012950 rattan cane Nutrition 0.000 description 2
- 230000000306 recurrent effect Effects 0.000 description 2
- 230000002040 relaxant effect Effects 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 230000000472 traumatic effect Effects 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 241000227129 Aconitum Species 0.000 description 1
- 244000296912 Ageratum conyzoides Species 0.000 description 1
- 235000004405 Ageratum conyzoides Nutrition 0.000 description 1
- 208000010470 Ageusia Diseases 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 241000758795 Aristolochiaceae Species 0.000 description 1
- 206010003402 Arthropod sting Diseases 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 235000016535 Capraria biflora Nutrition 0.000 description 1
- 241000208828 Caprifoliaceae Species 0.000 description 1
- 201000006082 Chickenpox Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010008909 Chronic Hepatitis Diseases 0.000 description 1
- 206010010144 Completed suicide Diseases 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 206010010726 Conjunctival oedema Diseases 0.000 description 1
- 241001450685 Corallium japonicum Species 0.000 description 1
- 241000220284 Crassulaceae Species 0.000 description 1
- 206010013554 Diverticulum Diseases 0.000 description 1
- 206010013789 Dry throat Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- 208000015220 Febrile disease Diseases 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 1
- 208000033469 Gastrooesophageal heterotopia Diseases 0.000 description 1
- 241001391115 Gelsemium elegans Species 0.000 description 1
- 241001071804 Gentianaceae Species 0.000 description 1
- 241000218791 Ginkgoaceae Species 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- 206010019345 Heat stroke Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 208000037319 Hepatitis infectious Diseases 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 235000017309 Hypericum perforatum Nutrition 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- 235000019687 Lamb Nutrition 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 206010062575 Muscle contracture Diseases 0.000 description 1
- 208000007443 Neurasthenia Diseases 0.000 description 1
- 241000233855 Orchidaceae Species 0.000 description 1
- 241000218180 Papaveraceae Species 0.000 description 1
- 201000005702 Pertussis Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 229910000805 Pig iron Inorganic materials 0.000 description 1
- 241000218641 Pinaceae Species 0.000 description 1
- 235000000405 Pinus densiflora Nutrition 0.000 description 1
- 240000008670 Pinus densiflora Species 0.000 description 1
- 235000011609 Pinus massoniana Nutrition 0.000 description 1
- 241000018650 Pinus massoniana Species 0.000 description 1
- 235000011610 Pinus tabuliformis Nutrition 0.000 description 1
- 241000018651 Pinus tabuliformis Species 0.000 description 1
- 235000011611 Pinus yunnanensis Nutrition 0.000 description 1
- 241000018652 Pinus yunnanensis Species 0.000 description 1
- 241000758706 Piperaceae Species 0.000 description 1
- 241001529246 Platymiscium Species 0.000 description 1
- 241000219050 Polygonaceae Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010037596 Pyelonephritis Diseases 0.000 description 1
- 208000006504 Scorpion Stings Diseases 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 206010041497 Spermatorrhoea Diseases 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 241000244317 Tillandsia usneoides Species 0.000 description 1
- 206010044302 Tracheitis Diseases 0.000 description 1
- 241000218220 Ulmaceae Species 0.000 description 1
- 206010046980 Varicella Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010047601 Vitamin B1 deficiency Diseases 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 208000016150 acute pharyngitis Diseases 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 230000003872 anastomosis Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 208000002894 beriberi Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 210000002318 cardia Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940121657 clinical drug Drugs 0.000 description 1
- 239000000039 congener Substances 0.000 description 1
- 208000006111 contracture Diseases 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 201000003146 cystitis Diseases 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 239000003640 drug residue Substances 0.000 description 1
- 208000017574 dry cough Diseases 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 206010016766 flatulence Diseases 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 208000005252 hepatitis A Diseases 0.000 description 1
- 206010019847 hepatosplenomegaly Diseases 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 230000001524 infective effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 230000001617 migratory effect Effects 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 201000002266 mite infestation Diseases 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 201000008383 nephritis Diseases 0.000 description 1
- 201000005111 ocular hyperemia Diseases 0.000 description 1
- 238000003305 oral gavage Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001175 peptic effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 210000001562 sternum Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 208000037816 tissue injury Diseases 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 210000002417 xiphoid bone Anatomy 0.000 description 1
- 239000009530 yishen Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a medicine for treating a blood stasis stationary chronic gastric ulcer and a preparation method. The medicine comprises the following raw materials: evergreen mucuna roots and leaves, loureiro clematis herb, sambucus chinensis, hylotelephium verticillatum, hairyshoot elm bark, ginkgo leaves, renanthera coccinea, statice sinensis girald, aralia undulata, purslane speedwell herb, clovershrub, loose knots, celandine, capitate knotweed herb, gentiana macrophylla, tangut monkshood herb, Chinese fevervine herb and roots, hairy waxmyrtle bark, cordate houttuynia, Indian kalimeris herb, dandelion, dindygulen peperomia herb, Chinese yam, groundnuts, caltrop starch, radix polygonati officinalis, radix ophiopogonis, rhizoma anemarrhenae, conic gymnadenia tuber, acanthopanax roots and liquorice. The medicine for treating the chronic gastric ulcer has the benefits that the medicine for treating the chronic gastric ulcer takes principles of promoting circulation, removing stasis, diminishing inflammation and alleviating pain, as well as clearing heat, removing toxicity, tonifying a spleen and nourishing a stomach, can improve the immunity of a human, is low in cost, complete in function, shorter in course of treatment, significant in curative effect, convenient to dose, safe and convenient, is free from medicinal residues, can increase the cure rate and lower the relapse rate obviously, and can be accepted by a patient easily; the possibility of medicine resistance is low; and the life quality of the patient can be improved significantly.
Description
Technical field
The present invention relates to pharmaceutical technology, particularly a kind of medicine and preparation method for the treatment of blood stasis stationary form chronic gastric ulcer.
Background technology
Gastric ulcer refers to the chronic ulcer between cardia to pylorus, is the one of peptic ulcer.Peptic ulcer can occur in Stomach duodenum, also can occur in lower esophageal, near stomach-intestinal anastomosis mouth and in your diverticulum of Meike on Ectopic Gastric Mucosa.The formation of these ulcer is all relevant with pepsic Digestion with gastric acid, therefore is called peptic ulcer.
Chronic gastric ulcer refers to the tissue injury exceeding muscular layer of mucosa that gastrointestinal mucosa is caused by peptic digestion liquid autodigestion.Its clinical characters is the rhythmicity upper abdominal pain of recurrent exerbation, often with belch, return acid, the sensation such as scorching hot, noisy, even also have Nausea and vomiting, hematemesis, have blood in stool.Circle, oval chronic ulcer is had in gastrointestinal local.
The cause of disease
1. life factor: gastric ulcer patient in some occupation as seemed more common in the middle of the people such as driver and doctor, may to owe rule relevant with diet.
2. inherited genetic factors: gastric ulcer has family history sometimes, especially child ulcers has family history person to account for 25% ~ 60%.
3. infective agent: Marshall demonstrates the final chief culprit that pylorus Roche bacillus is gastric ulcer, instead of thinks that pressure was excessive in the past, or acidic food causes.
4. Nervous and Mental Factors: psychentonia or worry, sentimentality, mental work is also too much primary disease risk factor.
5. chemical factor: the medicines such as long-term drink ethanol or long-term taking aspirin, corticosteroid easily cause this and sick to occur, in addition long-term smoking and drink strong tea like also having certain relation.
Clinical manifestation
Epigastrium pain is the cardinal symptom of primary disease.Multidigit in epigastrium, after also can appearing at left upper abdomen or breastbone, xiphoid-process.Be often dull pain, dull pain, distending pain, burn sample pain.The pain of gastric ulcer is many to be occurred in 1 hour after the meal, alleviated gradually after 1 ~ 2 hour, until reappear the above-mentioned rhythm and pace of moving things again after the feed of lower meal.Some patients can be asymptomatic, or using complication such as hemorrhage, perforation as onset symptoms.
Western medical treatment chronic gastric ulcer, must adhere to Long-term taking medicine.Because gastric ulcer is a chronic disease, and easily recur, it be made to heal completely, must Long-term taking medicine be adhered to.The course for the treatment of is longer, and clinical efficacy is not satisfactory, and the easy recurrent exerbation of the state of an illness, has a strong impact on the quality of life etc. of patient.
The traditional Chinese medical science thinks that chronic gastric ulcer belongs to stomachache, belch, acid regurgitation, vomiting and nausea, hematemesis, the category such as to have blood in stool, and clinical is primary symptom mainly with stomachache, is divided into Four types, i.e. hyperactive liver-qi attacking the stomach, liver stomach wind-cold type, blood stasis stationary form and spleen-stomach deficiency-cold etc.Wherein: the gastral cavilty twinge of blood stasis stationary form or cutting pain, localized pain and tenderness, very, tongue is dark or have stasis of blood skin dark stain point, hesitant pulse for postprandial pain.
Chinese medicine chronic gastric ulcer possesses unique advantage and feature: utilize Traditional Chinese medical theory, on the basis of Overall View, and enhancing human body immunity power, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, according to the treatment of different disease Mutiple Targets, drug effect is gone directly focus, safe and effective, the course for the treatment of is shorter, and not easily producing that drug resistance, cost price are lower, convenient drug administration, patient is easy to accept, and can significantly improve cure rate, reduce complication, reduce relapse rate, significantly improve the quality of life of patient.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of medicine and preparation method for the treatment of blood stasis stationary form chronic gastric ulcer, the present invention has blood circulation promoting and blood stasis dispelling, effect of anti-inflammatory analgetic, hold concurrently with heat-clearing and toxic substances removing, spleen reinforcing nourishing the stomach, blood yiqi, YIN nourishing and the production of body fluid promoting, cure mainly blood stasis stationary form chronic gastric ulcer, utilize Traditional Chinese medical theory, on the basis of Overall View, enhancing human body immunity power, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, drug effect is gone directly focus, safe and effective, the course for the treatment of is shorter, and have no side effect, cost price is lower, convenient drug administration, patient is easy to accept, cure rate can be significantly improved, reduce relapse rate, significantly improve the quality of life of patient.
In order to realize foregoing invention object, the invention provides a kind of medicine for the treatment of blood stasis stationary form chronic gastric ulcer, comprise following raw medicinal material: Radix Seu Caulis Mucunae Sempervirentis, Herba Clematidis loureirianae, Herba Sambuci Chiensis, Hylotelephium verticillatum (Linn.) H. Ohba, Cortex Ulmi virgatae, Folium Ginkgo, Herba Renantherae coccineae, Radix limonii sinensis, Radix Araliae undulatae, purslane speedwell Herba, Radix Campylotropis Hirtella (Herba Myrsines Africanae), Lignum Pini Nodi, Herba Chelidonii, Herba Polygoni Capitati, Radix Gentianae Macrophyllae, Herba Aconiti tangutici, Herba Paederiae, Cortex Myricae Rubrae (Cortex Myricae Esculentae), Herba Houttuyniae, Herba Kalimeridis, Herba Taraxaci, Herba Peperomiae Dindygulensis, Rhizoma Dioscoreae, Semen arachidis hypogaeae, Amylum Trapae, Rhizoma Polygonati Odorati, Radix Ophiopogonis, the Rhizoma Anemarrhenae, Rhizoma Gymnadeniae, Radix Et Caulis Acanthopanacis Senticosi and Radix Glycyrrhizae.
In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Seu Caulis Mucunae Sempervirentis 15-23 part, Herba Clematidis loureirianae 10-18 part, Herba Sambuci Chiensis 11-21 part, Hylotelephium verticillatum (Linn.) H. Ohba 8-16 part, Cortex Ulmi virgatae 13-22 part, Folium Ginkgo 15-21 part, Herba Renantherae coccineae 10-19 part, Radix limonii sinensis 13-18 part, Radix Araliae undulatae 11-20 part, purslane speedwell Herba 16-26 part, Radix Campylotropis Hirtella (Herba Myrsines Africanae) 12-19 part, Lignum Pini Nodi 10-20 part, Herba Chelidonii 6-10 part, Herba Polygoni Capitati 16-25 part, Radix Gentianae Macrophyllae 13-23 part, Herba Aconiti tangutici 5-9 part, Herba Paederiae 14-25 part, Cortex Myricae Rubrae (Cortex Myricae Esculentae) 10-18 part, Herba Houttuyniae 16-27 part, Herba Kalimeridis 17-28 part, Herba Taraxaci 16-24 part, Herba Peperomiae Dindygulensis 10-19 part, Rhizoma Dioscoreae 16-28 part, Semen arachidis hypogaeae 15-22 part, Amylum Trapae 13-21 part, Rhizoma Polygonati Odorati 16-25 part, Radix Ophiopogonis 12-24 part, Rhizoma Anemarrhenae 14-26 part, Rhizoma Gymnadeniae 16-28 part, Radix Et Caulis Acanthopanacis Senticosi 13-22 part and Radix Glycyrrhizae 17-24 part.
In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Seu Caulis Mucunae Sempervirentis 16-21 part, Herba Clematidis loureirianae 11-17 part, Herba Sambuci Chiensis 12-19 part, Hylotelephium verticillatum (Linn.) H. Ohba 10-15 part, Cortex Ulmi virgatae 14-20 part, Folium Ginkgo 17-20 part, Herba Renantherae coccineae 12-17 part, Radix limonii sinensis 14-17 part, Radix Araliae undulatae 13-19 part, purslane speedwell Herba 17-25 part, Radix Campylotropis Hirtella (Herba Myrsines Africanae) 13-17 part, Lignum Pini Nodi 12-18 part, Herba Chelidonii 7-9 part, Herba Polygoni Capitati 17-23 part, Radix Gentianae Macrophyllae 15-22 part, Herba Aconiti tangutici 6-8 part, Herba Paederiae 15-23 part, Cortex Myricae Rubrae (Cortex Myricae Esculentae) 11-17 part, Herba Houttuyniae 17-25 part, Herba Kalimeridis 19-26 part, Herba Taraxaci 17-21 part, Herba Peperomiae Dindygulensis 11-17 part, Rhizoma Dioscoreae 18-25 part, Semen arachidis hypogaeae 16-21 part, Amylum Trapae 15-20 part, Rhizoma Polygonati Odorati 17-23 part, Radix Ophiopogonis 14-23 part, Rhizoma Anemarrhenae 15-25 part, Rhizoma Gymnadeniae 17-26 part, Radix Et Caulis Acanthopanacis Senticosi 15-21 part and Radix Glycyrrhizae 18-21 part.
In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Seu Caulis Mucunae Sempervirentis 16 parts, Herba Clematidis loureirianae 17 parts, Herba Sambuci Chiensis 16 parts, Hylotelephium verticillatum (Linn.) H. Ohba 15 parts, Cortex Ulmi virgatae 17 parts, Folium Ginkgo 20 parts, Herba Renantherae coccineae 13 parts, Radix limonii sinensis 17 parts, Radix Araliae undulatae 13 parts, purslane speedwell Herba 23 parts, Radix Campylotropis Hirtella (Herba Myrsines Africanae) 17 parts, Lignum Pini Nodi 12 parts, Herba Chelidonii 7 parts, Herba Polygoni Capitati 23 parts, Radix Gentianae Macrophyllae 22 parts, Herba Aconiti tangutici 6 parts, Herba Paederiae 15 parts, Cortex Myricae Rubrae (Cortex Myricae Esculentae) 13 parts, Herba Houttuyniae 25 parts, Herba Kalimeridis 19 parts, Herba Taraxaci 18 parts, Herba Peperomiae Dindygulensis 11 parts, Rhizoma Dioscoreae 25 parts, Semen arachidis hypogaeae 16 parts, Amylum Trapae 20 parts, Rhizoma Polygonati Odorati 17 parts, Radix Ophiopogonis 14 parts, the Rhizoma Anemarrhenae 25 parts, Rhizoma Gymnadeniae 19 parts, Radix Et Caulis Acanthopanacis Senticosi 15 parts and 19 parts, Radix Glycyrrhizae.
In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Seu Caulis Mucunae Sempervirentis 19 parts, Herba Clematidis loureirianae 15 parts, Herba Sambuci Chiensis 12 parts, Hylotelephium verticillatum (Linn.) H. Ohba 10 parts, Cortex Ulmi virgatae 20 parts, Folium Ginkgo 17 parts, Herba Renantherae coccineae 12 parts, Radix limonii sinensis 15 parts, Radix Araliae undulatae 16 parts, purslane speedwell Herba 17 parts, Radix Campylotropis Hirtella (Herba Myrsines Africanae) 15 parts, Lignum Pini Nodi 18 parts, Herba Chelidonii 9 parts, Herba Polygoni Capitati 19 parts, Radix Gentianae Macrophyllae 19 parts, Herba Aconiti tangutici 7 parts, Herba Paederiae 15-23 part, Cortex Myricae Rubrae (Cortex Myricae Esculentae) 11 parts, Herba Houttuyniae 19 parts, Herba Kalimeridis 26 parts, Herba Taraxaci 21 parts, Herba Peperomiae Dindygulensis 17 parts, Rhizoma Dioscoreae 19 parts, Semen arachidis hypogaeae 18 parts, Amylum Trapae 15 parts, Rhizoma Polygonati Odorati 21 parts, Radix Ophiopogonis 23 parts, the Rhizoma Anemarrhenae 18 parts, Rhizoma Gymnadeniae 26 parts, Radix Et Caulis Acanthopanacis Senticosi 17 parts and 18 parts, Radix Glycyrrhizae.
In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Seu Caulis Mucunae Sempervirentis 21 parts, Herba Clematidis loureirianae 11 parts, Herba Sambuci Chiensis 19 parts, Hylotelephium verticillatum (Linn.) H. Ohba 11 parts, Cortex Ulmi virgatae 14 parts, Folium Ginkgo 19 parts, Herba Renantherae coccineae 17 parts, Radix limonii sinensis 14 parts, Radix Araliae undulatae 19 parts, purslane speedwell Herba 25 parts, Radix Campylotropis Hirtella (Herba Myrsines Africanae) 13 parts, Lignum Pini Nodi 13 parts, Herba Chelidonii 8 parts, Herba Polygoni Capitati 17 parts, Radix Gentianae Macrophyllae 15 parts, Herba Aconiti tangutici 8 parts, Herba Paederiae 17 parts, Cortex Myricae Rubrae (Cortex Myricae Esculentae) 17 parts, Herba Houttuyniae 17 parts, Herba Kalimeridis 23 parts, Herba Taraxaci 17 parts, Herba Peperomiae Dindygulensis 15 parts, Rhizoma Dioscoreae 18 parts, Semen arachidis hypogaeae 21 parts, Amylum Trapae 17 parts, Rhizoma Polygonati Odorati 23 parts, Radix Ophiopogonis 21 parts, the Rhizoma Anemarrhenae 15 parts, Rhizoma Gymnadeniae 17 parts, Radix Et Caulis Acanthopanacis Senticosi 21 parts and 21 parts, Radix Glycyrrhizae.
In order to realize goal of the invention better, the present invention also provides a kind of preparation method for the treatment of the medicine of blood stasis stationary form chronic gastric ulcer, and when the dosage form of described medicine is granule, its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
In order to realize goal of the invention better, the present invention also provides a kind of preparation method for the treatment of the medicine of blood stasis stationary form chronic gastric ulcer, and when the dosage form of described medicine is tablet, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 ~ 5 times is the ethanol of 85% ~ 90%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 3 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 ~ 3 hours, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.15 ~ 0.3 times of lactose, the starch of 0.2 ~ 0.35 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.
In order to realize goal of the invention better, the present invention also provides a kind of preparation method for the treatment of the medicine of blood stasis stationary form chronic gastric ulcer, and when the dosage form of described medicine is honey refining pill, its preparation method comprises the following steps:
Step 1: first Radix Seu Caulis Mucunae Sempervirentis, Cortex Ulmi virgatae, Folium Ginkgo, purslane speedwell Herba, Radix Campylotropis Hirtella (Herba Myrsines Africanae) and Lignum Pini Nodi are mixed in described ratio, distillation crystallization obtains powder;
Step 2: get surplus stock medical material again and mix in described ratio, add relative to 83-94% soak with ethanol 1-2 hour of mixture 2-6 times amount, heating extraction 2 times, each 1-1.5 hour, merge extractive liquid, 124-150 order filter, be the ultrafiltration post ultrafiltration of 4400-98000 again through the molecular weight that dams, when ultrafiltrate is evaporated to 87 DEG C, relative density is the extractum of 1.04, becomes component 1;
Step 3: step 2 Chinese medicine slag is added 4-6 times amount water soaking 1-2.5 hour, extract 1 time, extraction time is 1.5-2 hour, and thickening filtration is extractum shape, is component 2;
Step 4: said components 1 and component 2 two kinds of extractum are condensed into pasty state, add the powder that step 1 obtains, add Mel and be twisted into pill.
The beneficial effect that technical scheme provided by the invention is brought is: Drug therapy chronic gastric ulcer of the present invention for principle with blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic, is held concurrently with heat-clearing and toxic substances removing, spleen reinforcing nourishing the stomach, blood yiqi, YIN nourishing and the production of body fluid promoting, meanwhile, can be improved the immunity of people; There is cheap, no drug residue, pure natural property, nonhazardous, safe ready, not easily produce drug resistance, and complete function, the course for the treatment of are shorter, evident in efficacy, convenient drug administration, patient is easy to accept, can cure rate be significantly improved, reduce relapse rate, significantly improve the quality of life of patient.
Detailed description of the invention
The traditional Chinese medical science thinks that chronic gastric ulcer belongs to stomachache, belch, acid regurgitation, vomiting and nausea, hematemesis, the category such as to have blood in stool, and clinical is primary symptom mainly with stomachache.
Therefore, the present invention is with blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic is principle, hold concurrently with heat-clearing and toxic substances removing, spleen reinforcing nourishing the stomach, blood yiqi, YIN nourishing and the production of body fluid promoting, treatment blood stasis stationary form chronic gastric ulcer, the raw medicinal material of medicine comprises: Radix Seu Caulis Mucunae Sempervirentis, Herba Clematidis loureirianae, Herba Sambuci Chiensis, Hylotelephium verticillatum (Linn.) H. Ohba, Cortex Ulmi virgatae, Folium Ginkgo, Herba Renantherae coccineae, Radix limonii sinensis, Radix Araliae undulatae, purslane speedwell Herba, Radix Campylotropis Hirtella (Herba Myrsines Africanae), Lignum Pini Nodi, Herba Chelidonii, Herba Polygoni Capitati, Radix Gentianae Macrophyllae, Herba Aconiti tangutici, Herba Paederiae, Cortex Myricae Rubrae (Cortex Myricae Esculentae), Herba Houttuyniae, Herba Kalimeridis, Herba Taraxaci, Herba Peperomiae Dindygulensis, Rhizoma Dioscoreae, Semen arachidis hypogaeae, Amylum Trapae, Rhizoma Polygonati Odorati, Radix Ophiopogonis, the Rhizoma Anemarrhenae, Rhizoma Gymnadeniae, Radix Et Caulis Acanthopanacis Senticosi and Radix Glycyrrhizae.
Radix Seu Caulis Mucunae Sempervirentis, Herba Clematidis loureirianae, Herba Sambuci Chiensis, Hylotelephium verticillatum (Linn.) H. Ohba, Cortex Ulmi virgatae, Folium Ginkgo, Herba Renantherae coccineae, Radix limonii sinensis, Radix Araliae undulatae, purslane speedwell Herba blood circulation promoting and blood stasis dispelling in its side; Radix Campylotropis Hirtella (Herba Myrsines Africanae), Lignum Pini Nodi, Herba Chelidonii, Herba Polygoni Capitati, Radix Gentianae Macrophyllae, Herba Aconiti tangutici, Herba Paederiae, Cortex Myricae Rubrae (Cortex Myricae Esculentae) anti-inflammatory analgetic; Herba Houttuyniae, Herba Kalimeridis, Herba Taraxaci, Herba Peperomiae Dindygulensis heat-clearing and toxic substances removing; Rhizoma Dioscoreae, Semen arachidis hypogaeae, Amylum Trapae spleen reinforcing nourishing the stomach; Rhizoma Polygonati Odorati, Radix Ophiopogonis, Rhizoma Anemarrhenae YIN nourishing and the production of body fluid promoting; Rhizoma Gymnadeniae, Radix Et Caulis Acanthopanacis Senticosi blood yiqi; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.Make a general survey of full side, compatibility is rigorous.
Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:
Radix Seu Caulis Mucunae Sempervirentis: be the stem of the evergreen mucuna of leguminous plant.Bitter; Micro-hardship; Warm in nature.Return liver; Stomach warp.Promoting blood flow to regulate menstruation; To enrich blood relaxing muscles and tendons.Main have through uncomfortable; Dysmenorrhea; Amenorrhea; Puerperal blood deficiency; Anemia; Rheumatic arthralgia; Numb limbs and tense tendons; Traumatic injury.
Herba Clematidis loureirianae: wild Caulis Akebiae, Caulis Clematidis Chrysocomae, ferrum foot Wheeling, RADIX ANEMONAE.For rattan or the root of ranunculaceae plant gold pig-iron line.Sweet in the mouth; Light; Property is put down.Return liver; Kidney; Urinary bladder channel.Clearing away heat and promoting diuresis; Promoting blood circulation to restore menstrual flow; Expelling wind and removing dampness.Main dysuria; Edema; Damp-heat gonorrhoea; Rheumatic arthralgia; Traumatic injury; Scorching on wind-fire; Eye red pain; Amenorrhea; Mange.
Herba Sambuci Chiensis: be the stem and leaf of caprifoliaceae plant Herba Sambuci Chiensis.Sweet in the mouth; Micro-hardship; Property is put down.Dispel the wind; Dampness removing; Relaxing muscles and tendons; Invigorate blood circulation.Main air temperature arthralgia pain; Lumbago and skelalgia; Edema; Jaundice; Traumatic injury button damages; Disease that postpartum lochia can't go; Rubella pruritus; Erysipelas; Skin ulcer swells.
Hylotelephium verticillatum (Linn.) H. Ohba: be the herb of crassulaceae plants Hylotelephium verticillatum (Linn.) H. Ohba.Bitter; Cool.Blood circulation promoting and blood stasis dispelling; Removing toxic substances and promoting subsidence of swelling.Main impairment caused by overstrain lumbago; Gold creates blood; Nameless gall; Snake bite and insect sting.
Cortex Ulmi virgatae: another name Radix Ulmi Tonkinesis.For the bark of Ulmaceae hair elm.Bitter; Puckery; Property is put down.Blood circulation promoting and blood stasis dispelling; Hemostasis and pain-relieving.Main fracture; Traumatic pain; Traumatic hemorrhage; Gastrointestinal hemorrhage; Hematuria.
Folium Ginkgo: this product is the dried leaves of Ginkgoaceae plant Ginkgo biloba (maidenhair tree, Gong Sunshu).Sweet, bitter, puckery, flat.GUIXIN, lung meridian.Astringe the lung, relieving asthma, blood circulation promoting and blood stasis dispelling, pain relieving.For cough and asthma due to lung deficiency; Coronary heart disease, angina pectoris, hyperlipidemia.
Herba Renantherae coccineae: another name Corallium Japonicum Kishinouye, mountain see band, mountain opotism.For the herb of orchid Herba Renantherae coccineae.Bitter; Pungent; Flat.Return liver; Kidney channel.Expelling wind and removing dampness; Blood circulation promoting and blood stasis dispelling.Main air pain of dampness syndrome; Fracture.
Radix limonii sinensis: be the herb of gentianaceae plant Radix limonii sinensis.Bitter; Pungent; Cold in nature.Return lung; Liver; Large intestine channel.Blood circulation promoting and blood stasis dispelling; Clearing and antitussive.Blood stasis mass in the abdomen in main abdomen; Epersalgia cough.
Radix Araliae undulatae: be the root of Araliaceae Radix Araliae undulatae.Bitter in the mouth; Pungent; Cool in nature.Blood circulation promoting and blood stasis dispelling; Inducing menstruation to relieve menalgia; Expelling wind and removing dampness.Main traumatic injury; Fracture; Mass in the abdomen; Amenorrhea; Dysmenorrhea; Impairment caused by overstrain pain; Rheumatalgia.
Herba Aristolochiae: another name all drenches rattan, 300 liang of silver (" Handbook of Prescriptions for Emergencies of filling a vacancy "), Semen Oroxyli Seedling (Holy Benevolent Prescriptions), herba aristolochiae (" Prescriptions for Universal Relief ").For the stem and leaf of aristolochiaceae plant Fructus Aristolochiae.Bitter; Temperature.Return liver; Spleen; Kidney channel.Promoting flow of QI and blood; Inducing diuresis to remove edema; Removing toxic substances.Main stomachache; Colicky; Edema during pregnancy; Puerperal, vim and vigour were suffered from abdominal pain; Snake bite and insect sting.
Purslane speedwell Herba: be the herb of goatweed grave Herba Linderniae Crustaceae band insect gall.Sweet in the mouth; Micro-pungent; Property is put down.Return liver; Stomach; Lung meridian.Removing stasis to stop bleeding; Clearing heat for detumescence; Pain relieving.Main traumatic injury; Laryngopharynx swelling and pain; Ulcer sores; Hemoptysis; Spit blood; Epistaxis; Tripe peratodynia; Colicky; Dysmenorrhea.
Radix Campylotropis Hirtella (Herba Myrsines Africanae): for the Dou Ke Jing tip platymiscium Mao Jing tip is used as medicine with root.Micro-hardship, puckery, warm.Regulating menstruation and activating blood, pain relieving, convergence.For amenorrhea, dysmenorrhea, leucorrhea, stomachache; External is harnessed the Yellow River chickenpox, burn and scald.
Lignum Pini Nodi: be the tuberosity of the branchs such as pinaceae plant Pinus tabuliformis, Pinus massoniana Lamb, Pinus densiflora, pinus yunnanensis faranch.Bitter; Warm in nature.Return liver; Kidney channel.Dispeiling pathogenic wind and removing dampness; Channels sootheing and network vessel quickening; Promoting blood circulation and stopping pain.。Main anemofrigid-damp arthralgia, severe and migratory arthralgia pain; Foot numbness flaccidity is soft; Traumatic pain.
Herba Polygoni Capitati: be the herb of polygonaceae plant Herba Polygoni Capitati.Bitter; Pungent; Cool in nature.Clearing away heat-damp and promoting diuresis; Promoting blood circulation and stopping pain.Main dysentery; Pyelonephritis; Cystitis; Lithangiuria; Rheumatalgia; Traumatic injury; Mumps; Skin infection; Eczema.
Herba Chelidonii: another name mountain Rhizoma Coptidis, Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori), Niu Jinhua, eight steps are tight, Gelsemium elegans Benth. [Beijing].For Papaveraceae Chelidonium plant Herba Chelidonii is with all herbal medicine.Hardship, cool.Heat-clearing and toxic substances removing, pain relieving, cough-relieving.For gastritis, gastric ulcer, stomachache, enteritis, dysentery, jaundice, chronic tracheitis, pertussis; Paddy-field dermatitis is controlled in external, insect-bite.
Herba Aconiti tangutici: be the tuber of ranunculaceae plant Liangshan Mountain Aconitum carmichjaelii Debx..Cold in nature, taste fiber crops.Return spleen, stomach warp.Heat clearing and inflammation relieving.Control gastroenteritis.
Radix Gentianae Macrophyllae: pungent, bitter is flat.Return stomach, liver, gallbladder meridian.Wind-damp dispelling, clearing away damp-heat, stopping numbness pain.For rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached, afternoon fever, and infantile malnutrition generates heat.
Herba Paederiae: sweet acid; Flat.GUIXIN; Liver; Spleen; Kidney channel.Expelling wind and removing dampness; Promoting digestion and removing stagnation; Removing toxic substances and promoting subsidence of swelling; Promoting blood circulation and stopping pain.Cure mainly rheumatic arthralgia; Dyspeptic abdominal distention; Infantile malnutrition; Diarrhoea; Dysentery; Heatstroke; Jaundice; Hepatitis; Hepatosplenomegaly; Cough; Scrofula; Intestinal carbuncle; Innominate toxic swelling; Foot damp-edema is rotten; Burn and scald; Eczema; Dermatitis; Traumatic injury; Serpentis flood dragon scorpion sting.
Cortex Myricae Rubrae (Cortex Myricae Esculentae): be bark or the root bark of Myruca ceas vegetable hair Fructus Myricae rubrae.Puckery, flat.Antiinflammatory, convergence, antidiarrheal, upper blood, pain relieving, controls dysentery, enteritis, metrorrhagia, stomachache.
Herba Houttuyniae: pungent; Cold.Return liver; Lung meridian.Heat-clearing and toxic substances removing; Removing pus and relieving carbuncle; Inducing diuresis for treating stranguria syndrome.Main lung abscess vomiting pus; Expectorant dyspnea of heat type is coughed; Larynx; Hematodiarrhoea; Carbuncle sore tumefacting virus; Pyretic stranguria.
Herba Kalimeridis: pungent, bitter, cold.Heat-clearing and toxic substances removing, dissipating blood stasis stops blooding, removing food stagnancy.For cat fever, cough, acute pharyngitis, tonsillitis, mumps, infectious hepatitis, taste-blindness rate, infantile malnutrition, enteritis, dysentery, spits blood, metrorrhagia, menoxenia; External is controlled furuncle and is swollen and ache, mastitis, traumatic hemorrhage.
Herba Taraxaci: bitter in the mouth; Sweet; Cold in nature.Return liver; Stomach warp.Heat-clearing and toxic substances removing; Eliminating carbuncle eliminating stagnation.Main acute mastitis; Lung abscess; Intestinal carbuncle; Mumps; Furuncle carbuncle toxin; Conjunctival congestion and swelling pain; Cold, fever; Cough; Laryngopharynx swelling and pain; Stomach-fire; Intestinal is scorching; Dysentery; Hepatitis; Gallbladder frightens inflammation; Urinary tract infection; Snake bite and insect sting.
Herba Peperomiae Dindygulensis: be the herb of Piperaceae plant Herba Peperomiae Dindygulensis.Pungent; Cool.Return lung; Spleen; Liver; Kidney channel.Heat-clearing and toxic substances removing; Blood stasis-eliminating and stagnation-dissipating; Inducing diuresis to remove edema.Main lung-heat cough with asthma; Measles; Sore; Cancerous protuberance; Burn and scald; Traumatic injury; Oedema due to nephritis.
Rhizoma Dioscoreae: sweet, flat.Return spleen, lung, kidney channel.Spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.
Rhizoma Polygonati Odorati: sweet, is slightly cold.Attach to the lung and stomach meridians.Nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst.For lung stomach-Yin wound, cough caused by dryness-heat, dry throat and mouth, interior-heat is quenched one's thirst.
Semen arachidis hypogaeae: sweet; Flat; Return spleen; Lung meridian.Strengthening the spleen and nourishing the stomach, moistening the lung and resolving phlegm.Main spleen insufficiency, regurgitation is not relaxed, and newborn woman's milk is few, beriberi, xeropulmonary cough, constipation due to dry stool.
Amylum Trapae: the sarcocarp for Trapaceae phase dry Pedicellus et Pericarpium Trapae or its congener smashes the starch of juice levigation.Sweet in the mouth; Cool in nature.Strengthening the spleen and nourishing the stomach; Summer heat clearing toxin resolving.Main insufficiency of the spleen weak; Summer-heat excessive thirst; Quench one's thirst.
Radix Ophiopogonis: sweet, micro-hardship, is slightly cold.GUIXIN, lung, stomach warp.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough.Chronic consumptive disease is coughed, and Tianjin wound is thirsty, vexed insomnia, and interior-heat is quenched one's thirst, dryness of the intestine constipation; Pharyngeal diphtheria.
The Rhizoma Anemarrhenae: bitter in the mouth; Cold in nature.Return lung; Stomach; Kidney channel.Clearing away heat-fire; Nourshing Yin and drynsessmoistening prescription; To quench the thirst relieving restlessness.Main epidemic febrile disease; High hot excessive thirst; Cough and asthma; Cough caused by dryness; Constipation; Osteopyrexia and fever; Restlessness of asrhenia type and insomnia; To quench one's thirst stranguria with turbid discharge.
Rhizoma Gymnadeniae: sweet; Flat.Return lung; Spleen; Stomach warp.Relieving cough and asthma; Yishen Jianpi; Regulate the flow of vital energy and blood; Pain relieving.Main cough and asthma due to lung deficiency; Asthenia is become thin; Neurasthenia; Suffer from a deficiency of the kidney lassitude loin and legs; Sexual impotence; Spermatorrhea; Frequent micturition; Chronic hepatitis; Chronic diarrhea; Lose blood; Leukorrhagia; Breast is few; Traumatic injury.
Radix Et Caulis Acanthopanacis Senticosi: be the drying of Araliaceae Radix Et Caulis Acanthopanacis Senticosi, root and rhizome or stem.Pungent, micro-hardship, temperature.Return spleen, kidney, heart channel.Replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization.For deficiency of spleen-YANG and kidneyYANG, body void is weak, inappetence, soreness of waist and knee joint, insomnia and dreamful sleep.
Radix Glycyrrhizae: sweet in the mouth, property is put down.QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, coordinating the actions of various ingredients in a prescription.Can treating disorders in five ZANG-organs six internal organs cold and heat pathogen, hard muscles and bones, longue meat, times strength, removing toxic substances, clothes are made light of one's life by commiting suicide and are prolonged life for a long time.Raw by pathogenic fire purging heat, ripe use is fallen apart exterior cold, goes pharyngalgia, except pathogenic heat, and slow healthy energy, yin nourishing blood, tonifying the spleen and stomach, lung moistening.Radix Glycyrrhizae Preparata, is longer than warming middle-JIAO, and with sweet temperature QI invigorating, relieving spasm to stop pain power is strong.Weak for insufficiency of the spleen stomach, cardiopalmus irregularly intermittent and regularly intermittent pulse etc.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 granule of the present invention
Get Radix Seu Caulis Mucunae Sempervirentis 16g, Herba Clematidis loureirianae 17g, Herba Sambuci Chiensis 16g, Hylotelephium verticillatum (Linn.) H. Ohba 15g, Cortex Ulmi virgatae 17g, Folium Ginkgo 20g, Herba Renantherae coccineae 13g, Radix limonii sinensis 17g, Radix Araliae undulatae 13g, purslane speedwell Herba 23g, Radix Campylotropis Hirtella (Herba Myrsines Africanae) 17g, Lignum Pini Nodi 12g, Herba Chelidonii 7g, Herba Polygoni Capitati 23g, Radix Gentianae Macrophyllae 22g, Herba Aconiti tangutici 6g, Herba Paederiae 15g, Cortex Myricae Rubrae (Cortex Myricae Esculentae) 13g, Herba Houttuyniae 25g, Herba Kalimeridis 19g, Herba Taraxaci 18g, Herba Peperomiae Dindygulensis 11g, Rhizoma Dioscoreae 25g, Semen arachidis hypogaeae 16g, Amylum Trapae 20g, Rhizoma Polygonati Odorati 17g, Radix Ophiopogonis 14g, Rhizoma Anemarrhenae 25g, Rhizoma Gymnadeniae 19g, Radix Et Caulis Acanthopanacis Senticosi 15g and Radix Glycyrrhizae 19g.
Its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 6 times, mixture is the ethanol of 95%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 DEG C subsequently under vacuum 0.08Mpa, relative density is the mastic of 1.10, spraying dry, the inlet temperature 170 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.2 times in the dried cream powder obtained, makes granule, in 45 DEG C of dryings, obtains granule.
Embodiment 2 tablet of the present invention
Get Radix Seu Caulis Mucunae Sempervirentis 19g, Herba Clematidis loureirianae 15g, Herba Sambuci Chiensis 12g, Hylotelephium verticillatum (Linn.) H. Ohba 10g, Cortex Ulmi virgatae 20g, Folium Ginkgo 17g, Herba Renantherae coccineae 12g, Radix limonii sinensis 15g, Radix Araliae undulatae 16g, purslane speedwell Herba 17g, Radix Campylotropis Hirtella (Herba Myrsines Africanae) 15g, Lignum Pini Nodi 18g, Herba Chelidonii 9g, Herba Polygoni Capitati 19g, Radix Gentianae Macrophyllae 19g, Herba Aconiti tangutici 7g, Herba Paederiae 15-23g, Cortex Myricae Rubrae (Cortex Myricae Esculentae) 11g, Herba Houttuyniae 19g, Herba Kalimeridis 26g, Herba Taraxaci 21g, Herba Peperomiae Dindygulensis 17g, Rhizoma Dioscoreae 19g, Semen arachidis hypogaeae 18g, Amylum Trapae 15g, Rhizoma Polygonati Odorati 21g, Radix Ophiopogonis 23g, Rhizoma Anemarrhenae 18g, Rhizoma Gymnadeniae 26g, Radix Et Caulis Acanthopanacis Senticosi 17g and Radix Glycyrrhizae 18g.
Its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 90%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 3 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 400 object micropowders;
3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.2 times, 0.2 times of lactose, the starch of 0.3 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.03 times of magnesium stearate, granulate, tabletting, makes.
Embodiment 3 honey refining of the present invention pill
Get Radix Seu Caulis Mucunae Sempervirentis 21g, Herba Clematidis loureirianae 11g, Herba Sambuci Chiensis 19g, Hylotelephium verticillatum (Linn.) H. Ohba 11g, Cortex Ulmi virgatae 14g, Folium Ginkgo 19g, Herba Renantherae coccineae 17g, Radix limonii sinensis 14g, Radix Araliae undulatae 19g, purslane speedwell Herba 25g, Radix Campylotropis Hirtella (Herba Myrsines Africanae) 13g, Lignum Pini Nodi 13g, Herba Chelidonii 8g, Herba Polygoni Capitati 17g, Radix Gentianae Macrophyllae 15g, Herba Aconiti tangutici 8g, Herba Paederiae 17g, Cortex Myricae Rubrae (Cortex Myricae Esculentae) 17g, Herba Houttuyniae 17g, Herba Kalimeridis 23g, Herba Taraxaci 17g, Herba Peperomiae Dindygulensis 15g, Rhizoma Dioscoreae 18g, Semen arachidis hypogaeae 21g, Amylum Trapae 17g, Rhizoma Polygonati Odorati 23g, Radix Ophiopogonis 21g, Rhizoma Anemarrhenae 15g, Rhizoma Gymnadeniae 17g, Radix Et Caulis Acanthopanacis Senticosi 21g and Radix Glycyrrhizae 21g.
Its preparation method comprises the following steps:
Step 1: first Radix Seu Caulis Mucunae Sempervirentis, Cortex Ulmi virgatae, Folium Ginkgo, purslane speedwell Herba, Radix Campylotropis Hirtella (Herba Myrsines Africanae) and Lignum Pini Nodi are mixed in described ratio, distillation crystallization obtains powder;
Step 2: get surplus stock medical material again and mix in described ratio, add 90% soak with ethanol 2 hours, the heating extraction 2 times relative to mixture 4 times amount, each 1 hour, merge extractive liquid, 130 orders filter, be the ultrafiltration post ultrafiltration of 80000 again through the molecular weight that dams, when ultrafiltrate is evaporated to 87 DEG C, relative density is the extractum of 1.04, becomes component 1;
Step 3: step 2 Chinese medicine slag is added 4-6 times amount water soaking 2 hours, extract 1 time, extraction time is 2 hours, and thickening filtration is extractum shape, is component 2;
Step 4: said components 1 and component 2 two kinds of extractum are condensed into pasty state, add the powder that step 1 obtains, add Mel and be twisted into pill.
Toxicity test:
Acute toxicity test: application NIH mice 40, SPF level, male and female half and half, body weight 17 ~ 24g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; Granule prepared by embodiments of the invention 1 is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage granule LD50>28.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage Chinese medicine of the present invention is 745 times of quantity.Therefore the granule acute toxicity of the embodiment of the present invention 1 is low, clinical drug safety.
Long term toxicity test: the tablet of the embodiment of the present invention 2 is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Long term toxicity test: the honey of the embodiment of the present invention 3 refining pill is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: anthology Out-patient Department case 260 example, age 27-66 year, man 171 example, female 89 example, be divided into four groups at random, four groups of patients, at age, sex, course of disease zero difference, have comparability.
Granules in Treating group: 65 people, male 42 people, female 23 people.
Tablet in treatment group: 65 people, male 43 people, female 22 people.
Honey refining pill treatment group: 65 people, male 43 people, female 22 people.
Western medicine group: 65 people, male 43 people, female 22 people.
Diagnostic criteria:
Diagnostic criteria reference " new Chinese medicine guideline of clinical investigations ",
Western medicine diagnose standard
1. the periodicity of prolonged and repeated outbreak, the chronic epigastrium pain of rhythmicity, using basic medicine can be alleviated.
2. epigastrium has limitation deeply in tenderness.
3. x-ray canel barium meal contrast examination has Ulcer niche.
4. splanchnoscopy ulcer of visible active stage.
TCM syndrome diagnosis blood stasis stationary form: gastral cavilty twinge or cutting pain, localized pain and tenderness, very, tongue is dark or have stasis of blood skin dark stain point, hesitant pulse for postprandial pain.
Allly meet above-mentioned clinical criteria and be diagnosed as chronic gastric ulcer, Chinese medical discrimination blood stasis stationary form.
Therapeutic Method:
Granules in Treating group: take granule prepared by the embodiment of the present invention 1, every day 3 times, each 1 bag 10 days is 1 course for the treatment of.
Tablet in treatment group: tablet prepared by the oral embodiment of the present invention 2, every day 3 times, each 4 10 days is 1 course for the treatment of.
Honey refining pill treatment group: honey refining pill prepared by the oral embodiment of the present invention 3, every day 3 times, one time 2, within 10 days, be 1 course for the treatment of.
Western medicine group: oral omeprazole, coordinates amoxicillin treatment.Omeprazole 1 20mg, every day 2 times, each 0.5g in amoxicillin, every day 1 time 10 days was 1 course for the treatment of.
Clinical efficacy is observed after two courses for the treatment of.
Efficacy assessment standard:
Gastroscopy:
(1) clinical recovery: ulcer and around inflammation all disappear.
(2) effective: ulcer disappears, and still has inflammation.
(3) effective: ulcer area is less than more than 50%.
(4) invalid: ulcer area reduces not as good as 50%.
Therapeutic outcome:
1, adopt Drug therapy blood stasis stationary form chronic gastric ulcer of the present invention, treat after 20 days, relative to Western medicine on therapeutic effect, there is significant improvement.
Granules in Treating group: totally 65 people, wherein 62 people's clinical recoveries, 2 people are effective, and 1 people is effective, and 0 people is invalid, and total effective rate reaches 100%;
Tablet in treatment group: totally 65 people, wherein 61 people's clinical recoveries, 3 people are effective, and 1 people is effective, and 0 people is invalid, and total effective rate reaches 100%;
Honey refining pill treatment group: totally 65 people, wherein 61 people's clinical recoveries, 3 people are effective, and 1 people is effective, and 0 people is invalid, and total effective rate reaches 100%;
Western medicine group: totally 65 people, wherein 35 people's clinical recoveries, 9 people are effective, and 11 people are effective, and 10 people are invalid, and total effective rate reaches 84.6%.
As can be seen here, the relative Western medicine of Drug therapy blood stasis stationary form chronic gastric ulcer of the present invention, effective percentage is high.
2, adopt Drug therapy blood stasis stationary form chronic gastric ulcer of the present invention, treat after 20 days, cure and effective number, significantly shorten treating on the course for the treatment of relative to Western medicine.
Granules in Treating group: clinical recovery and effective number 64 people, wherein 1-10 days, 25 people, account for 39.1%; 11-20 days, 39 people, account for 60.9%;
Tablet in treatment group: clinical recovery and effective number 64 people, wherein 1-10 days, 24 people, account for 37.5%; 11-20 days, 40 people, account for 62.5%;
Honey refining pill treatment group: clinical recovery and effective number 64 people, wherein 1-10 days, 23 people, account for 35.9%; 11-20 days, 41 people, account for 64.1%;
Western medicine group: clinical recovery and effective number 44 people, wherein 1-10 days, 8 people, account for 18.2%; 11-20 days, 36 people, account for 81.8%.
As can be seen here, the relative Western medicine of Drug therapy blood stasis stationary form chronic gastric ulcer of the present invention, curative effect is fast.
According to the clinical statistics that above curative effect is stated, medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect.
Meanwhile, to four groups of clinical recoveries and effective follow-up of patients 1 year, result is added up:
Granules in Treating group clinical recovery and effective 64 examples, 62 example nothing recurrences of clinical recovery, 1 case relapsed in effective 2 routine patients, relapse rate is 1.6%;
Tablet in treatment group clinical recovery and effective 64 examples, 61 example nothing recurrences of clinical recovery, 1 case relapsed in effective 3 routine patients, relapse rate is 1.6%;
Honey refining pill treatment group clinical recovery and effective 64 examples, 61 example nothing recurrences of clinical recovery, 1 case relapsed in effective 3 routine patients, relapse rate is 1.6%;
Western medicine group clinical recovery and effective 44 routine patients, 35 example recurrence 7 examples of clinical recovery, recur 7 examples in effective 9 routine patients, relapse rate is 31.8%.
Known according to above statistics, medicine provided by the invention not easily recurs after healing blood stasis stationary form chronic gastric ulcer relative to Western medicine.
Model case:
Patient Liu, man, 56 years old, in October, 2011 went to a doctor, gastral cavilty twinge, localized pain and tenderness, and very, tongue has stasis of blood skin dark stain point to postprandial pain, hesitant pulse.The course of disease 10 years, periodical attack.Gastroscopy, can in stomach see circle or oval, bottom is smooth, the ulcer of neat in edge.Western medicine diagnose: chronic gastric ulcer, Chinese medical discrimination is blood stasis stationary form.Take the granule of pharmaceutical preparation embodiment 1 of the present invention, every day 3 times, each 1 bag, after 4 days, symptom obviously alleviates, and flatulence disappears, and fully recovers after 16 days.Follow up a case by regular visits to and do not recur for 1 year.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (9)
1. treat the medicine of blood stasis stationary form chronic gastric ulcer for one kind, it is characterized in that, comprise following raw medicinal material: Radix Seu Caulis Mucunae Sempervirentis, Herba Clematidis loureirianae, Herba Sambuci Chiensis, Hylotelephium verticillatum (Linn.) H. Ohba, Cortex Ulmi virgatae, Folium Ginkgo, Herba Renantherae coccineae, Radix limonii sinensis, Radix Araliae undulatae, purslane speedwell Herba, Radix Campylotropis Hirtella (Herba Myrsines Africanae), Lignum Pini Nodi, Herba Chelidonii, Herba Polygoni Capitati, Radix Gentianae Macrophyllae, Herba Aconiti tangutici, Herba Paederiae, Cortex Myricae Rubrae (Cortex Myricae Esculentae), Herba Houttuyniae, Herba Kalimeridis, Herba Taraxaci, Herba Peperomiae Dindygulensis, Rhizoma Dioscoreae, Semen arachidis hypogaeae, Amylum Trapae, Rhizoma Polygonati Odorati, Radix Ophiopogonis, the Rhizoma Anemarrhenae, Rhizoma Gymnadeniae, Radix Et Caulis Acanthopanacis Senticosi and Radix Glycyrrhizae.
2. medicine according to claim 1, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Seu Caulis Mucunae Sempervirentis 15-23 part, Herba Clematidis loureirianae 10-18 part, Herba Sambuci Chiensis 11-21 part, Hylotelephium verticillatum (Linn.) H. Ohba 8-16 part, Cortex Ulmi virgatae 13-22 part, Folium Ginkgo 15-21 part, Herba Renantherae coccineae 10-19 part, Radix limonii sinensis 13-18 part, Radix Araliae undulatae 11-20 part, purslane speedwell Herba 16-26 part, Radix Campylotropis Hirtella (Herba Myrsines Africanae) 12-19 part, Lignum Pini Nodi 10-20 part, Herba Chelidonii 6-10 part, Herba Polygoni Capitati 16-25 part, Radix Gentianae Macrophyllae 13-23 part, Herba Aconiti tangutici 5-9 part, Herba Paederiae 14-25 part, Cortex Myricae Rubrae (Cortex Myricae Esculentae) 10-18 part, Herba Houttuyniae 16-27 part, Herba Kalimeridis 17-28 part, Herba Taraxaci 16-24 part, Herba Peperomiae Dindygulensis 10-19 part, Rhizoma Dioscoreae 16-28 part, Semen arachidis hypogaeae 15-22 part, Amylum Trapae 13-21 part, Rhizoma Polygonati Odorati 16-25 part, Radix Ophiopogonis 12-24 part, Rhizoma Anemarrhenae 14-26 part, Rhizoma Gymnadeniae 16-28 part, Radix Et Caulis Acanthopanacis Senticosi 13-22 part and Radix Glycyrrhizae 17-24 part.
3. medicine according to claim 1 and 2, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Seu Caulis Mucunae Sempervirentis 16-21 part, Herba Clematidis loureirianae 11-17 part, Herba Sambuci Chiensis 12-19 part, Hylotelephium verticillatum (Linn.) H. Ohba 10-15 part, Cortex Ulmi virgatae 14-20 part, Folium Ginkgo 17-20 part, Herba Renantherae coccineae 12-17 part, Radix limonii sinensis 14-17 part, Radix Araliae undulatae 13-19 part, purslane speedwell Herba 17-25 part, Radix Campylotropis Hirtella (Herba Myrsines Africanae) 13-17 part, Lignum Pini Nodi 12-18 part, Herba Chelidonii 7-9 part, Herba Polygoni Capitati 17-23 part, Radix Gentianae Macrophyllae 15-22 part, Herba Aconiti tangutici 6-8 part, Herba Paederiae 15-23 part, Cortex Myricae Rubrae (Cortex Myricae Esculentae) 11-17 part, Herba Houttuyniae 17-25 part, Herba Kalimeridis 19-26 part, Herba Taraxaci 17-21 part, Herba Peperomiae Dindygulensis 11-17 part, Rhizoma Dioscoreae 18-25 part, Semen arachidis hypogaeae 16-21 part, Amylum Trapae 15-20 part, Rhizoma Polygonati Odorati 17-23 part, Radix Ophiopogonis 14-23 part, Rhizoma Anemarrhenae 15-25 part, Rhizoma Gymnadeniae 17-26 part, Radix Et Caulis Acanthopanacis Senticosi 15-21 part and Radix Glycyrrhizae 18-21 part.
4. according to the arbitrary described medicine of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Seu Caulis Mucunae Sempervirentis 16 parts, Herba Clematidis loureirianae 17 parts, Herba Sambuci Chiensis 16 parts, Hylotelephium verticillatum (Linn.) H. Ohba 15 parts, Cortex Ulmi virgatae 17 parts, Folium Ginkgo 20 parts, Herba Renantherae coccineae 13 parts, Radix limonii sinensis 17 parts, Radix Araliae undulatae 13 parts, purslane speedwell Herba 23 parts, Radix Campylotropis Hirtella (Herba Myrsines Africanae) 17 parts, Lignum Pini Nodi 12 parts, Herba Chelidonii 7 parts, Herba Polygoni Capitati 23 parts, Radix Gentianae Macrophyllae 22 parts, Herba Aconiti tangutici 6 parts, Herba Paederiae 15 parts, Cortex Myricae Rubrae (Cortex Myricae Esculentae) 13 parts, Herba Houttuyniae 25 parts, Herba Kalimeridis 19 parts, Herba Taraxaci 18 parts, Herba Peperomiae Dindygulensis 11 parts, Rhizoma Dioscoreae 25 parts, Semen arachidis hypogaeae 16 parts, Amylum Trapae 20 parts, Rhizoma Polygonati Odorati 17 parts, Radix Ophiopogonis 14 parts, the Rhizoma Anemarrhenae 25 parts, Rhizoma Gymnadeniae 19 parts, Radix Et Caulis Acanthopanacis Senticosi 15 parts and 19 parts, Radix Glycyrrhizae.
5. according to the arbitrary described medicine of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Seu Caulis Mucunae Sempervirentis 19 parts, Herba Clematidis loureirianae 15 parts, Herba Sambuci Chiensis 12 parts, Hylotelephium verticillatum (Linn.) H. Ohba 10 parts, Cortex Ulmi virgatae 20 parts, Folium Ginkgo 17 parts, Herba Renantherae coccineae 12 parts, Radix limonii sinensis 15 parts, Radix Araliae undulatae 16 parts, purslane speedwell Herba 17 parts, Radix Campylotropis Hirtella (Herba Myrsines Africanae) 15 parts, Lignum Pini Nodi 18 parts, Herba Chelidonii 9 parts, Herba Polygoni Capitati 19 parts, Radix Gentianae Macrophyllae 19 parts, Herba Aconiti tangutici 7 parts, Herba Paederiae 15-23 part, Cortex Myricae Rubrae (Cortex Myricae Esculentae) 11 parts, Herba Houttuyniae 19 parts, Herba Kalimeridis 26 parts, Herba Taraxaci 21 parts, Herba Peperomiae Dindygulensis 17 parts, Rhizoma Dioscoreae 19 parts, Semen arachidis hypogaeae 18 parts, Amylum Trapae 15 parts, Rhizoma Polygonati Odorati 21 parts, Radix Ophiopogonis 23 parts, the Rhizoma Anemarrhenae 18 parts, Rhizoma Gymnadeniae 26 parts, Radix Et Caulis Acanthopanacis Senticosi 17 parts and 18 parts, Radix Glycyrrhizae.
6. according to the arbitrary described medicine of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Seu Caulis Mucunae Sempervirentis 21 parts, Herba Clematidis loureirianae 11 parts, Herba Sambuci Chiensis 19 parts, Hylotelephium verticillatum (Linn.) H. Ohba 11 parts, Cortex Ulmi virgatae 14 parts, Folium Ginkgo 19 parts, Herba Renantherae coccineae 17 parts, Radix limonii sinensis 14 parts, Radix Araliae undulatae 19 parts, purslane speedwell Herba 25 parts, Radix Campylotropis Hirtella (Herba Myrsines Africanae) 13 parts, Lignum Pini Nodi 13 parts, Herba Chelidonii 8 parts, Herba Polygoni Capitati 17 parts, Radix Gentianae Macrophyllae 15 parts, Herba Aconiti tangutici 8 parts, Herba Paederiae 17 parts, Cortex Myricae Rubrae (Cortex Myricae Esculentae) 17 parts, Herba Houttuyniae 17 parts, Herba Kalimeridis 23 parts, Herba Taraxaci 17 parts, Herba Peperomiae Dindygulensis 15 parts, Rhizoma Dioscoreae 18 parts, Semen arachidis hypogaeae 21 parts, Amylum Trapae 17 parts, Rhizoma Polygonati Odorati 23 parts, Radix Ophiopogonis 21 parts, the Rhizoma Anemarrhenae 15 parts, Rhizoma Gymnadeniae 17 parts, Radix Et Caulis Acanthopanacis Senticosi 21 parts and 21 parts, Radix Glycyrrhizae.
7., according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described medicine is granule, its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
8., according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described medicine is tablet, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 ~ 5 times is the ethanol of 85% ~ 90%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 3 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 ~ 3 hours, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.15 ~ 0.3 times of lactose, the starch of 0.2 ~ 0.35 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.
9. according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described medicine is honey refining pill, its preparation method comprises the following steps:
Step 1: first Radix Seu Caulis Mucunae Sempervirentis, Cortex Ulmi virgatae, Folium Ginkgo, purslane speedwell Herba, Radix Campylotropis Hirtella (Herba Myrsines Africanae) and Lignum Pini Nodi are mixed in described ratio, distillation crystallization obtains powder;
Step 2: get surplus stock medical material again and mix in described ratio, add relative to 83-94% soak with ethanol 1-2 hour of mixture 2-6 times amount, heating extraction 2 times, each 1-1.5 hour, merge extractive liquid, 124-150 order filter, be the ultrafiltration post ultrafiltration of 4400-98000 again through the molecular weight that dams, when ultrafiltrate is evaporated to 87 DEG C, relative density is the extractum of 1.04, becomes component 1;
Step 3: step 2 Chinese medicine slag is added 4-6 times amount water soaking 1-2.5 hour, extract 1 time, extraction time is 1.5-2 hour, and thickening filtration is extractum shape, is component 2;
Step 4: said components 1 and component 2 two kinds of extractum are condensed into pasty state, add the powder that step 1 obtains, add Mel and be twisted into pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510123877.4A CN104645061A (en) | 2015-03-21 | 2015-03-21 | Medicine for treating blood stasis stationary chronic gastric ulcer and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510123877.4A CN104645061A (en) | 2015-03-21 | 2015-03-21 | Medicine for treating blood stasis stationary chronic gastric ulcer and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104645061A true CN104645061A (en) | 2015-05-27 |
Family
ID=53237031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510123877.4A Pending CN104645061A (en) | 2015-03-21 | 2015-03-21 | Medicine for treating blood stasis stationary chronic gastric ulcer and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104645061A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105250694A (en) * | 2015-10-23 | 2016-01-20 | 徐保利 | Chinese herb preparation for treating gastric asthenia yin deficiency type gastrohelcosis and preparing method |
-
2015
- 2015-03-21 CN CN201510123877.4A patent/CN104645061A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 刘杨: ""王长洪教授应用清法治疗胃溃疡经验"", 《辽宁中医药大学学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105250694A (en) * | 2015-10-23 | 2016-01-20 | 徐保利 | Chinese herb preparation for treating gastric asthenia yin deficiency type gastrohelcosis and preparing method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102302733B (en) | Oral Chinese medicinal composition for treating ovarian cyst | |
| CN103463449A (en) | Traditional Chinese medicine composite used for treating haemorrhoids and preparation method and application thereof | |
| CN104998197A (en) | Traditional Chinese medicine composition for treating liver cancer | |
| CN104758606A (en) | Traditional Chinese medicine composition for treating qi-deficiency and sputum-stasis type hepatic hemangioma | |
| CN107582989A (en) | A kind of tying-in strong bone, the Chinese medicine composition and preparation method thereof of relaxing tendons and activating collaterals | |
| CN104645061A (en) | Medicine for treating blood stasis stationary chronic gastric ulcer and preparation method | |
| CN104840773A (en) | Traditional Chinese medicine composition for treating vertebral artery type cervical spondylopathy and method for preparing same | |
| CN104800610A (en) | Traditional Chinese medicine preparation for treating Parkinson's disease and preparation method thereof | |
| CN107496624A (en) | A kind of orthopaedics medicinal liquor and preparation method thereof | |
| CN105456933A (en) | Traditional Chinese medicine capable of activating blood to remove stasis and clearing and activating channels and collaterals and preparation method of traditional Chinese medicine | |
| CN106177404A (en) | A kind of Chinese medicine composition treating the hepatic and renal YIN deficiency and preparation method thereof | |
| CN105998512A (en) | Pharmaceutical composition for the treatment of femoral shaft fracture and preparation method thereof | |
| CN104958638A (en) | Traditional Chinese medicine for treating liver-kidney yin deficiency type hemicrania and preparation method for traditional Chinese medicine | |
| CN104162112B (en) | A kind of pharmaceutical composition and preparation method thereof | |
| CN105435165A (en) | Traditional Chinese medicine for treating cluster headache in anesthesia department and preparing method thereof | |
| CN104435151A (en) | Traditional Chinese medicine preparation for treating hypertension and preparation method of traditional Chinese medicine preparation | |
| CN105079392A (en) | Preparation for treating ischialgia and preparation method thereof | |
| CN104922595A (en) | Traditional Chinese medicinal preparation for herpes zoster and preparation method thereof | |
| CN105560430A (en) | Blood activating and dysentery stopping preparation for treating chronic dysentery | |
| CN104524149A (en) | Pharmaceutical composition for preventing and treating acute nephritis and application thereof | |
| CN105194476A (en) | Powder having function of promoting blood circulation to remove meridian obstruction and being used for treating coronary heart diseases | |
| CN102370848A (en) | Chinese herbal medicine for treating damp evil-caused leucorrhea of women | |
| CN104523860A (en) | Liver calming and yang suppressing preparation for treating hypertension complicated with fullness in head and preparation method of liver calming and yang suppressing preparation | |
| CN105616871A (en) | Traditional Chinese medicinal preparation for treating hypothyroidism and method for preparing traditional Chinese medicinal preparation for treating hypothyroidism | |
| CN105213894A (en) | A kind of kidney tonifying anti-perspiration formulation and method for making for the treatment of night sweat |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150527 |