CN104667049A - Traditional Chinese medicine preparation for treating pneumonia and preparation method of traditional Chinese medicine preparation - Google Patents
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating pneumonia. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 19-24 parts of platycodon grandiflorum, 14-20 parts of dragonhead, 9-15 parts of schizonepeta spike, 8-16 parts of cirrhopetalum, 15-19 parts of semen raphani, 9-15 parts of scutellaria indica, 8-16 parts of fresh rhizoma phragmitis, 11-16 parts of buttonbush, 9-16 parts of adenophora trachelioides, 8-16 parts of wedelia chinensis, 12-16 parts of canscora lucidissima, 9-17 parts of virginia grape fern herb with root, 15-20 parts of snakegourd fruit, 10-15 parts of habenaria petelotii, 15-23 parts of radix bupleuri and 17-25 parts of semen coicis. The traditional Chinese medicine preparation has the excellent effects that the traditional medicine property is organically combined with the modern pharmacology of traditional Chinese medicines; kinds of medicinal materials cooperatively work to play the roles in diffusing the lung, relieving exterior syndrome, eliminating phlegm by cooling, and invigorating spleen to remove dampness, has a radical cure effect on pneumonia caused by kinds of reasons, and is available in medicine source; and the medicinal materials are low in cost, free of a side effect and relatively high in popularization value.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine preparation and preparation method for the treatment of pneumonia.
Background technology
Pneumonia refers to the inflammation of last air flue, alveolar and interstitial lung eventually.Can by pathogenic microorganism such as antibacterial, virus, fungus, parasites, and the chemical factors such as lonizing radiation, imbedibility foreign body causes.Clinical cardinal symptom is heating, cough, expectoration, sputum mixed with blood, can accompany chest pain or dyspnea etc.Cause the reason of pneumonia a lot, as antibacterial (streptococcus pneumoniae, α-hemolytic streptococcus, staphylococcus aureus, bacillus canalis capsulatus, hemophilus influenza, Pseudomonas aeruginosa, bacteria escherichia coli, bacillus pyocyaneus etc.), virus (coronavirus, adenovirus, influenza virus, cytomegalovirus, herpes simplex virus etc.), fungus (Candida albicans, aspergillosis, actinomyces etc.), atypical pathogens (as legionella, mycoplasma, chlamydia, rickettsia, toxoplasma, protozoon etc.), chemical factors (suction of radioactivity, gastric acid, medicine etc.).Lobar pneumonia, bronchiolitis, interstitial pneumonia can be divided into by the region of anatomy.Acute pneumonia, organizing pneumonia, chronic pneumonia is divided into by the course of disease.
Pneumonia generally with expectorant, heat, cough, breathe heavily, incite as main manifestations.The category of the card such as " pneumonia cough ", " lung-QI stagnation syndrome ", " wind-warm lung-heat " of Chinese medicine can be belonged to from its morbidity and clinical manifestation.The record comparatively horn of plenty that Chinese medical book is coughed to pneumonia, the name of disease head of pneumonia cough sees " numb section living person pandect ", and it is when describing measles and pneumonia infection symptom, and as occurred, " breathe heavily and without tears, furthermore flaring of nares " becomes " pneumonia cough ".Ancient Chinese medicine is thought, cause of disease system patient affection of exogenous wind-cold, the wind heat of pneumonia cough enter from fur mouth and nose, invade lung meridian, or make spleen lung not enough, and raw wetting makes expectorant, stops up stagnant lung network, meets exopathogen and triggers.In sum, the pathological change of pneumonia is that heresy closes lung network, impairment of purifying function of the lung and causing.Treatment on, take differentiation of tcm Therapeutic Principle, fundamentally eliminate focus, prevent complication.
Application publication number CN 103877517 A(application number 201410141298.8) Chinese invention patent document disclose a kind of Chinese medicine for the treatment of pneumonia, be made up of the raw material of following weight parts proportioning: Herba Taraxaci 5, Herba Patriniae 8, Herba Scutellariae Barbatae 10, Rhizoma Polygoni Cuspidati 12, Flos Chrysanthemi 7, Herba Lysimachiae 9, Fructus Forsythiae 6, Fructus Gardeniae 4, Radix Platycodonis 7, the Radix Paeoniae Alba 9, Ramulus Uncariae Cum Uncis 11, Rhizoma Cimicifugae 12, Bombyx Batryticatus 10, Rhizoma Et Radix Notopterygii 8, Radix Saposhnikoviae 4, Scorpio 5, Ramulus Cinnamomi 9, Fructus Corni 12, Radix Dipsaci 11, Radix Angelicae Pubescentis 10, Radix Angelicae Sinensis 8, Thallus Laminariae (Thallus Eckloniae) 6, Sargassum 4, Spica Prunellae 12, Radix Curcumae 10, Rhizoma Cyperi 11, Radix Ophiopogonis 7, the Radix Rehmanniae 9, Galla Chinensis 13, Fructus Aurantii Immaturus 14, Radix Achyranthis Bidentatae 16, Caulis Spatholobi 15, Radix Aconiti Lateralis Preparata 8, Periostracum Cicadae 7, Herba Asari 9, Rhizoma Chuanxiong 12, the Radix Angelicae Dahuricae 11, Massa Medicata Fermentata 5, Flos Carthami 12, Herba Agrimoniae 5, Semen Benincasae 7, Semen Cuscutae 8, Herba Taxilli 12, Radix Codonopsis 4, Radix Bupleuri 5, PINGDIMU 8.Application publication number CN 103550664 A(application number 201310532387.0) Chinese invention patent document disclose a kind of Chinese medicine for the treatment of pneumonia, it is made up of the raw material of following weight proportioning: Semen Raphani 5-15, Pericarpium Citri Reticulatae 8-17, Fructus Amomi 3-9, Rhizoma Polygoni Cuspidati 8-15, Herba Taraxaci 10-20, Herba Houttuyniae 20-30, Radix Scutellariae 30-40, Flos Lonicerae 30-40, Fructus Forsythiae 10-18, Herba Schizonepetae 8-15.Application publication number CN 103585470 A(application number 201310649373.7) Chinese invention patent document disclose a kind of Chinese medicine for the treatment of pneumococcal pneumonia, be prepared from by the medical material of following weight proportion: ear leaf Herba lysimachiae capillipedis 20 parts, Radix calophylli membranacei 16 parts, Folium Pini tenuifoliae 12 parts, Herba Adenostemmatis 8 parts, 15 parts, Fructus psidii guajavae immaturus bark, Ormosia fordiana 10 parts, Herba Melastomatis polyanthi 12 parts, Herba Bidentis Tripartitae 15 parts, Radix Euryae Chinensis 8 parts, Pedicularis spicata 8 parts, Petasites japonicus 12 parts, Herba Lycianthis Lysimachioidis 15 parts, Radix Satyrii nepalensis 12 parts, bean curd 12 parts, Radix Crossostephii Chinensis 14 parts, Herba Girardiniae Palmatae 10 parts, Fusong Aconitum carmichjaelii Debx. 12 parts, northeast winged euonymus 10 parts, Herba Adonidis 16 parts.
Tradition western medicine pneumonia, based on broad ectrum antibiotic and comprehensive symptomatic treatment, has certain curative effect to it, but still not ideal enough to the alleviation of partial symptoms, and long-term taking side effect is large.The traditional Chinese medical science emphasizes the advantages such as organic conception, regulating yin and yang, treating both the principal and secondary aspects of a disease, toxic and side effects are little owing to having, and is more and more approved by people.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of prepare simple, take Chinese medicine preparation and preparation method that safety, effect treat pneumonia significantly.Chinese medicine preparation determined curative effect of the present invention, cure rate are high, and the scope of application is wide.
Technical scheme of the present invention is:
The Chinese medicine preparation for the treatment of pneumonia, is prepared from by following bulk drugs, is weight portion: Radix Platycodonis 19-24; Herba Dracocephali Integrifolii 14-20; Herba Schizonepetae 9-15; Herba Cirrohopetali Andersonii 8-16; Semen Raphani 15-19; Herba Scutellariae indicae 9-15; Fresh Rhizoma Phragmitis 8-16; Buttonbush 11-16; Radix Adenophorae Trachelioidis 9-16; Herbia Wedeliae 8-16; Herba Canscorae 12-16; Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 9-17; Fructus Trichosanthis 15-20; Habenria petelotii Gagnep. 10-15; Radix Bupleuri 15-23; Semen Coicis 17-25.
In preferred scheme, Radix Platycodonis 21-22; Herba Dracocephali Integrifolii 16-18; Herba Schizonepetae 11-13; Herba Cirrohopetali Andersonii 10-14; Semen Raphani 16-18; Herba Scutellariae indicae 11-13; Fresh Rhizoma Phragmitis 10-14; Buttonbush 13-14; Radix Adenophorae Trachelioidis 11-14; Herbia Wedeliae 10-14; Herba Canscorae 13-15; Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 12-14; Fructus Trichosanthis 16-19; Habenria petelotii Gagnep. 11-14; Radix Bupleuri 17-21; Semen Coicis 19-23.
Be more preferably, Radix Platycodonis 21.5; Herba Dracocephali Integrifolii 17; Herba Schizonepetae 12; Herba Cirrohopetali Andersonii 12; Semen Raphani 17; Herba Scutellariae indicae 12; Fresh Rhizoma Phragmitis 12; Buttonbush 13.5; Radix Adenophorae Trachelioidis 12.5; Herbia Wedeliae 12; Herba Canscorae 14; Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 13; Fructus Trichosanthis 17.5; Habenria petelotii Gagnep. 12.5; Radix Bupleuri 19; Semen Coicis 21.
The Chinese medicine preparation for the treatment of pneumonia, be made into pharmaceutically acceptable decoction, preparation method is as follows:
(1) get new fresh Rhizoma Phragmitis and smash juice, juice is for subsequent use; Semen Coicis rubs, and is placed in non iron container, adds pure water (preferably adding the pure water of the 4.5 times of material quantities) slow fire boiling 20 minutes of 3-6 times of material quantity, filters, stays decoction for subsequent use;
(2) surplus stock medicine is together placed in Chinese medicinal pot, adds clear water and do not have powder 3-5cm, soak 2-5 hour, then big fire is heated to boil, and turns little fire and decocts twice, respectively decocts 50-60 minute (preferably each respectively decoction 55 minutes) at every turn, filter, merge twice decocting liquid; Medicinal residues add the clear water of 3 times amount again, and little fire decocts 15-35 minute (preferred little fire decocts 25 minutes), and filter, filtrate and decocting liquid merge;
(3) step (2) gained decocting liquid is evaporated to 1/4 of original volume, adds step (1) gained pharagmitis rhizoma juice and Yiyiren Decoction while hot, stir, dry heat sterilization, encapsulation, to obtain final product.
The preparation method of the Chinese medicine decoction of above-mentioned treatment pneumonia, preferred scheme is, step (2) is soaked 3-4 hour (preferably soaking 3.5 hours).
The preparation method of the Chinese medicine decoction of above-mentioned treatment pneumonia, preferred scheme is, in step (3), the temperature of dry heat sterilization is 96-110 DEG C (temperature of preferred dry heat sterilization is 100-106 DEG C, and the temperature of the dry heat sterilization be more preferably is 103 DEG C).
The preparation method of the Chinese medicine decoction of above-mentioned treatment pneumonia, preferred scheme is, in step (3), the time of dry heat sterilization is 12-24 minute (time of preferred dry heat sterilization is 16-20 minute, and the time of the dry heat sterilization be more preferably is 18 minutes).
The preparation method of described thick paste agent is:
(1) Radix Platycodonis, Semen Raphani, buttonbush, Radix Adenophorae Trachelioidis, Fructus Trichosanthis and Radix Bupleuri are placed in Chinese medicine air drier, in 65-85 DEG C of dry 1-1.4 hour (being preferable over 75 DEG C of dryings 1.2 hours), taking out, be ground into fine powder, for subsequent use; Semen Coicis is ground into powder, for subsequent use;
(2) by step (1) gained medicated powder, mixing, sieves, obtains mixing fine powders for subsequent use; New fresh Rhizoma Phragmitis smashes juice, and taking juice is for subsequent use;
(3) Herba Dracocephali Integrifolii, Herba Schizonepetae, Herba Cirrohopetali Andersonii, Herba Scutellariae indicae, Herbia Wedeliae, Herba Canscorae, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. and Habenria petelotii Gagnep. are placed in Chinese medicinal pot, add the clear water (preferably adding the clear water of 7 times of material quantities) of 6-8 times of material quantity, slow fire boiling twice, each respectively decoction 45-65 minute (preferably each each decoction 55 minutes), filter, merge twice decocting liquid;
(4) in above-mentioned decocting liquid, add step (2) gained mixing fine powders and pharagmitis rhizoma juice, continue slow fire boiling 20-30 minute (preferably continuing slow fire boiling 25 minutes), filter, filtrate reduced in volume to 80 DEG C relative density is the thick paste of 1.31-1.33, sterilizing, encapsulation, to obtain final product.
The preparation method of described capsule is:
Each crude drug is pulverized, crosses 90-130 mesh sieve (preferred mistake 110 mesh sieve), according to 0.25-0.45g/ grain (preferred 0.35g/ grain) metering, be processed into capsule shape dosage form according to the preparation for processing of capsule.
The preparation method of described tablet is:
(1) take various crude drug by formula proportion, dry, grind into powder, cross 100-140 mesh sieve (preferred mistake 120 mesh sieve), obtain mixed powder;
(2) above-mentioned medicated powder is measured according to 0.3-0.5g/ sheet (preferably according to 0.4g/ sheet), make tablet dosage form according to the preparation for processing of tablet.
Scientific formula of the present invention, preparation method is simple, effectively easy to use, safe.In addition, excellent results of the present invention also shows:
1,traditional property of medicine and Chinese medicine modern pharmacology organically combine by the present invention, utilize ingredients synergism, jointly play effect of diffusing lung, relieving exterior syndrome, removing heat-phlegm, invigorating spleen to remove dampness, have the effect of thoroughly curing to the pneumonia that a variety of causes causes;
2,medicine of the present invention not only improves the clinical symptoms of patient, alleviates misery, and can strengthen patient's body constitution significantly, enables the fast quick-recovery of patient, determined curative effect;
3,medicine source of the present invention is easy to get, and medical material is with low cost, has no side effect, and has higher promotional value.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Platycodonis: base is former: this product is the dry root of Campanulaceae Radix Platycodonis.Chemical analysis: root is containing Saponin, and its composition known has Polygalacic acid, platycodigenin and glucose.-β-D-Glucose glycoside, Δ 7-stigmastenol, betulin is transplanted again containing chondrillasterol, α-Herba Spinaciae steroid, and containing inulin, platycodonin.Three triterpene class materials are obtained again: platycogenic acid A, B and C from Radix Platycodonis.Nature and flavor: bitter, pungent are flat.Gui Jing: return lung meridian.Effect: lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.Cure mainly: for cough with copious phlegm, uncomfortable in chest smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
Herba Dracocephali Integrifolii: base is former: be the herb of labiate Herba Dracocephali Integrifolii.Chemical analysis: aerial parts, mainly containing flavonoid glycosides (more than 9 kinds), also contains sterol, lactone compound, Saponin, acidic resins etc.Nature and flavor: " bitter, temperature." function cures mainly: cough-relieving, eliminate the phlegm, relieving asthma.For cough, phlegm dyspnea, chronic bronchitis.
Herba Schizonepetae: base is former: this product is the dry spica of labiate Herba Schizonepetae.Nature and flavor: pungent, tepor.Gui Jing: return lung, Liver Channel.Effect: induce sweat loose wind, rash.Cure mainly: induce sweat loose wind, rash.For flu, headache, measles, rubella, skin infection from the beginning of.Parch to black treating hematochezia, metrorrhagia, puerperal blood faints.
Herba Cirrohopetali Andersonii: base is former: be the herb of orchid volume lobe orchid.Nature and flavor: " Traditional Chinese Medicine in Sichuan will ": " warm in nature, sweet in the mouth is nontoxic." function cures mainly: controlling cough and spitting blood, rheumatic arthralgia.
Semen Raphani: base is former: be the mature seed of crucifer Radix Raphani.Chemical analysis: the fatty oil of seed, volatile oil.Methanthiol etc. is had in volatile oil.Containing volume erucic acid, linoleic acid, linolenic acid and glycerol sinapate etc. in fatty oil.Still claim raphanin containing antibiotic substance.Nature and flavor: Xin Gan are flat.Gui Jing: enter lung, stomach warp.Function cures mainly: therapeutic method to keep the adverse QI flowing downwards Dingchuan, eliminates indigestion and phlegm.Control cough phlegm dyspnea, stagnation of QI due to dyspepsia, abdominal distention uncomfortable in chest, heavy after dysentery.
Herba Scutellariae indicae: base is former: be the whole herb with root of labiate Herba Scutellariae indicae.Chemical analysis: herb is containing flavonoid, phenolic constituent, aminoacid, organic acid such as baicalins.Nature and flavor: arduous are flat.Gui Jing: " Quanzhou book on Chinese herbal medicine ": " enter the heart, liver, lung three warp." function cures mainly: dispel the wind, invigorate blood circulation, removing toxic substances, pain relieving.Control traumatic injury, spit blood, hemoptysis, carbuncle, furunculosis, acute throat trouble, toothache.
Fresh Rhizoma Phragmitis: base is former: be the rhizome of grass phragmites communis.Chemical analysis: Rhizoma Phragmitis is containing Coixol, and protein 5%, fat 1%, carbohydrate 51%, asparagine 0.1%.Phragmites communis cellulose 48 ~ 54%, lignin about 18.2%, xylan about 12.4%, ash 2.8%.Polysaccharide hydrolysis produces D-xylose, L-arabinose, D-Glucose, D-galactose and two kinds of alduronic acid.Another containing volume vitamin B1, B2 and C, and tricin.Nature and flavor: sweet, cold.Gui Jing: enter lung, stomach warp.Function cures mainly: heat clearing away, promotes the production of body fluid, relieving restlessness, preventing or arresting vomiting.Control calentura excessive thirst, gastropyretic vomiting, dysphagic, regurgitation, consumptive lung disease, lung abscess.And separate Fugu ocellatus ichthyotoxin.
Buttonbush: base former Rubiaceae Cephalanthus plant buttonbush, is used as medicine with root.Nature and flavor: bitter, cool.Function cures mainly: heat-clearing and toxic substances removing, eliminating stasis to stop pain, hemostasia and promoting granulation, expelling phlegm for arresting cough.For influenza, upper respiratory tract infection, laryngopharynx swelling and pain, pneumonia, cough, orchitis, parotitis, mastitis; Traumatic injury is controlled in external, furuncle and phyma, fracture (or with root bark steeping in wine 1 ~ 2 day, dry grind into powder deposited, can hemostasis and pain-relieving).
Radix Adenophorae Trachelioidis: base is former: be the root of campanulaceae Lady bell plant Radix Adenophorae Trachelioidis, slender lobule Radix Adenophorae Trachelioidis.The property of medicine: dry, cold.Return lung, spleen channel.Function cures mainly: moistening the lung and resolving the phlegm, heat-clearing and toxic substances removing.Cure mainly xeropulmonary cough, laryngopharynx swelling and pain, quench one's thirst, furuncle carbuncle sore, drug intoxication." not Lu ": " principal solution hundred poison of drug." " dietitian's mental state ": " sharp lung qi, and in, improving eyesight, pain relieving." " Treatise on Dietetic Therapy ": " borax starts, and gets the excellent of root food.”
Herbia Wedeliae: base is former: be herb or the root of feverfew Herbia Wedeliae.Pharmacological action: the water extract lumbar injection of herb has certain inhibitory action to mice ehrlich carcinoma.Nature and flavor: 1. " book on Chinese herbal medicine asks former ": " sweet light, be slightly cold." 2. " Fujian Chinese herbal medicine ": " micro-salty, cool." function cures mainly: heat clearing away, removing toxic substances, blood stasis dispelling, detumescence.Control diphtheria, pertussis, dysentery, hemorrhoid, traumatic injury.
Herba Canscorae: base is former: be the herb of gentianaceae plant Herba Canscorae.Nature and flavor: 1. " Guangxi Chinese herbal medicine ": " the micro-sweet micro-hardship of taste, property is put down, nontoxic." 2. " the practical Chinese herbal medicine in Guangxi newly selects ": " and mildly bitter flavor, cool in nature." function cures mainly: heat-clearing and toxic substances removing, promoting blood circulation and stopping pain.Control cough due to lung-heat, hepatitis, leptospirosis, jaundice, chest pain, stomachache, the stasis of blood in traumatic injury, venom.
Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw.: base is former: be the whole herb with root of Botrychiaceae plant Herba pteridii latiusculi Cai.Nature and flavor: " Shaanxi Chinese herbal medicine ": " pained, cool." function cures mainly: 1. " Shaanxi Chinese herbal medicine ": " heat-clearing and toxic substances removing, suppressing the hyperactive liver eliminating stagnation.Control lung abscess, conjunctivitis, impairment caused by overstrain, venom, scrofula." 2. Nanchuan " conventional Chinese herbal medicine handbook ": " tonify deficiency lung moistening, relieving cough and resolving phlegm.Control cough, weak and celostomia after being ill.”
Fructus Trichosanthis: base is former: this product is the dry mature fruit of cucurbitaceous plant Fructus Trichosanthis or trichosanthes rosthornii Harms.Nature and flavor: sweet, micro-hardship, cold.Gui Jing: return lung, stomach, large intestine channel.Function cures mainly: clearing away heat and eliminating phlegm, and relieving stuffiness of the chest by dispersing aggregation of pathogens moisturizes laxation.For cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, blocked-up chest feeling of fullness, acute mastitis, lung abscess, and acute appendicitis swells and ache, constipation.
Habenria petelotii Gagnep.: base is former: the orchid family Habenria petelotii Gagnep., with all herbal medicine.Nature and flavor: sweet, micro-hardship are flat.Function cures mainly: nourishing YIN and moistening the lung, and tonify deficiency benefit is damaged.
Radix Bupleuri: base is former: this product is the dry root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..Nature and flavor: bitter, cool.Gui Jing: return liver, gallbladder meridian.Effect: reconciling superficies and interior, soothing the liver, yang invigorating.Control alternate attack of chill and fever, fullness in the chest and hypochondriac pain, bitter taste is deaf, headache and dizziness, malaria, lower sharp proctoptosis, menoxenia, uterine prolapse.
Semen Coicis: base is former: be the kernel of grass Semen Coicis.Nature and flavor: sweet light, cool.Gui Jing: enter spleen, lung, kidney channel.Function cures mainly: spleen invigorating, tonifying the lung, heat clearing away, dampness removing.Control and have loose bowels, arthralgia chiefly caused by damp pathogen, the contracture of muscle arteries and veins, joint stuffiness, edema, beriberi, consumptive lung disease, lung abscess, acute appendicitis, stranguria with turbid discharge, leucorrhea.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the Chinese medicine preparation for the treatment of pneumonia, is prepared from by following bulk drugs, is weight portion (65g/ part): Radix Platycodonis 19 parts; Herba Dracocephali Integrifolii 14 parts; Herba Schizonepetae 9 parts; Herba Cirrohopetali Andersonii 8 parts; Semen Raphani 15 parts; Herba Scutellariae indicae 9 parts; Fresh Rhizoma Phragmitis 8 parts; Buttonbush 11 parts; Radix Adenophorae Trachelioidis 9 parts; Herbia Wedeliae 8 parts; Herba Canscorae 12 parts; Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 9 parts; Fructus Trichosanthis 15 parts; Habenria petelotii Gagnep. 10 parts; Radix Bupleuri 15 parts; Semen Coicis 17 parts.
The preparation method of the Chinese medicine decoction of above-mentioned treatment pneumonia is:
(1) get new fresh Rhizoma Phragmitis and smash juice, juice is for subsequent use; Semen Coicis rubs, and is placed in non iron container, adds the pure water slow fire boiling 20 minutes of 3 times of material quantities, filters, stays decoction for subsequent use;
(2) surplus stock medicine is together placed in Chinese medicinal pot, adds clear water and do not have powder 3-5cm, soak 2 hours, then big fire is heated to boil, and turns little fire and decocts twice, respectively decoct 50 minutes at every turn, filter, merge twice decocting liquid; Medicinal residues add the clear water of 3 times amount again, and little fire decocts 15 minutes, and filter, filtrate and decocting liquid merge;
(3) step (2) gained decocting liquid is evaporated to 1/4 of original volume, adds step (1) gained pharagmitis rhizoma juice and Yiyiren Decoction while hot, stir, 96 DEG C of dry heat sterilizations 12 minutes, encapsulation, to obtain final product.
The instructions of taking of decoction of the present invention is: once a day, each 180-200mL, warmly takes, 5 days courses for the treatment of.
Model case a: XX, man, 13 years old, October 15 calendar year 2001 was to our hospital.Its female Dai Shu: patient occurred heating paresthesia suddenly without obvious inducement before three days, with cough, has productive cough not go out.Once treated in local clinic, medication is not quite clear, resolution of fever after treatment, and cough has no improvement, next day, and patient's cough increases the weight of, rapid breathing.Introduce my institute's treatment through neighbours.Check: patient coughs, and pants, wheezing sound in the throat, rapid breathing is indigestion and loss of appetite, and urine is adjusted, red tongue, yellow and greasy fur, rapid pulse; Moist rale done by two fullness of the lung cloth; Rabat shows pulmonary's visible patch shape shade.Be diagnosed as the cough of (stagnation of phlegm is gas-tight type) pneumonia.
Take the Chinese medicine decoction of the present embodiment gained treatment pneumonia, instructions of taking: once a day, each 180-200mL, warmly takes, 5 days courses for the treatment of.After taking a course for the treatment of, patient's cough, wheezing symptoms are obviously alleviated; After continuing two courses for the treatment of of medication, patient's cough, expectoration disappear, and lab testing various functions recovers normal; Patient's self-induction is fully recovered.
embodiment 2the Chinese medicine preparation for the treatment of pneumonia, is prepared from by following bulk drugs, is weight portion (45g/ part): Radix Platycodonis 24 parts; Herba Dracocephali Integrifolii 20 parts; Herba Schizonepetae 15 parts; Herba Cirrohopetali Andersonii 16 parts; Semen Raphani 19 parts; Herba Scutellariae indicae 15 parts; Fresh Rhizoma Phragmitis 16 parts; Buttonbush 16 parts; Radix Adenophorae Trachelioidis 16 parts; Herbia Wedeliae 16 parts; Herba Canscorae 16 parts; Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 17 parts; Fructus Trichosanthis 20 parts; Habenria petelotii Gagnep. 15 parts; Radix Bupleuri 23 parts; Semen Coicis 25 parts.
The preparation method of the traditional Chinese medicine thick paste agent of above-mentioned treatment pneumonia is:
(1) Radix Platycodonis, Semen Raphani, buttonbush, Radix Adenophorae Trachelioidis, Fructus Trichosanthis and Radix Bupleuri are placed in Chinese medicine air drier, in 75 DEG C of dryings 1.2 hours, take out, be ground into fine powder, for subsequent use; Semen Coicis is ground into powder, for subsequent use;
(2) by step (1) gained medicated powder, mixing, sieves, obtains mixing fine powders for subsequent use; New fresh Rhizoma Phragmitis smashes juice, and taking juice is for subsequent use;
(3) Herba Dracocephali Integrifolii, Herba Schizonepetae, Herba Cirrohopetali Andersonii, Herba Scutellariae indicae, Herbia Wedeliae, Herba Canscorae, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. and Habenria petelotii Gagnep. are placed in Chinese medicinal pot, add the clear water of 7 times of material quantities, slow fire boiling twice, each each decoction 55 minutes, filters, merges twice decocting liquid;
(4) in above-mentioned decocting liquid, add step (2) gained mixing fine powders and pharagmitis rhizoma juice, continue slow fire boiling 25 minutes, filter, filtrate reduced in volume to a 80 DEG C relative density is the thick paste of 1.31-1.33, sterilizing, and encapsulation, to obtain final product.
The instructions of taking of thick paste agent of the present invention is: twice daily, and each 3-5 spoon, pours in cup, and about 90 DEG C boiled water pour, and evenly takes, 5 days courses for the treatment of.
embodiment 3the Chinese medicine preparation for the treatment of pneumonia, is prepared from by following bulk drugs, is weight portion (60g/ part): Radix Platycodonis 21 parts; Herba Dracocephali Integrifolii 16 parts; Herba Schizonepetae 11 parts; Herba Cirrohopetali Andersonii 10 parts; Semen Raphani 16 parts; Herba Scutellariae indicae 11 parts; Fresh Rhizoma Phragmitis 10 parts; Buttonbush 13 parts; Radix Adenophorae Trachelioidis 11 parts; Herbia Wedeliae 10 parts; Herba Canscorae 13 parts; Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 12 parts; Fructus Trichosanthis 16 parts; Habenria petelotii Gagnep. 11 parts; Radix Bupleuri 17 parts; Semen Coicis 19 parts.
The preparation method of the Chinese medicine capsules of above-mentioned treatment pneumonia is:
Each crude drug is pulverized, crosses 110 mesh sieves, according to the metering of 0.35g/ grain, be processed into capsule shape dosage form according to the preparation for processing of capsule.
The instructions of taking of capsule of the present invention is: every day three times, each 3-5 grain, and warm water takes, 5 days courses for the treatment of.
Model case: Wu XX, female, 33 years old, patient came here on May 22nd, 2011 and goes to a doctor.Patient's readme: before 5 days, unexpected health of suffering from cold occurs uncomfortable.Have heating paresthesia when just starting, after taking febrifuge afterwards, burning is moved back, and occurs cough symptom morning next day, coughs thick sputum, with asthma symptom.Health is good before, does not have major disease.Check: patient's cough is comparatively violent, and expectorant, in white, is measured medium, comparatively thickness, rapid breathing, without chest pain, without nausea and vomiting, without heating, night sweat.Have a medical check-up: two BITONG gas is smooth, and pharyngeal visible hyperemia, tonsil is without enlargement.Two pulmonary respiration sound is thick, right upper lung audible and a small amount of moist rale.Heart rate 80 beats/min, rule is neat.Rabat is pointed out: a small amount of inflammation stove of right upper lung oozes out.Be diagnosed as upper right pneumonia.
Take the Chinese medicine capsules of the present embodiment gained treatment pneumonia, instructions of taking: every day three times, each 3-5 grain, warm water takes, 5 days courses for the treatment of.After taking a course for the treatment of, patient's cough, asthma symptom are obviously alleviated; After continuing two courses for the treatment of of medication, patient's cough, expectoration disappear, and lab testing various functions recovers normal; Patient's self-induction is fully recovered.Pay a return visit after three months, in order, nothing recurs patient body.
embodiment 4the Chinese medicine preparation for the treatment of pneumonia, is prepared from by following bulk drugs, is weight portion (50g/ part): Radix Platycodonis 22 parts; Herba Dracocephali Integrifolii 18 parts; Herba Schizonepetae 13 parts; Herba Cirrohopetali Andersonii 14 parts; Semen Raphani 18 parts; Herba Scutellariae indicae 13 parts; Fresh Rhizoma Phragmitis 14 parts; Buttonbush 14 parts; Radix Adenophorae Trachelioidis 14 parts; Herbia Wedeliae 14 parts; Herba Canscorae 15 parts; Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 14 parts; Fructus Trichosanthis 19 parts; Habenria petelotii Gagnep. 14 parts; Radix Bupleuri 21 parts; Semen Coicis 23 parts.
The preparation method of the Chinese medicinal tablet of above-mentioned treatment pneumonia is:
(1) take various crude drug by formula proportion, dry, grind into powder, cross 120 mesh sieves, obtain mixed powder;
(2) above-mentioned medicated powder is measured according to 0.4g/ sheet, make tablet dosage form according to the preparation for processing of tablet.
The instructions of taking of Tablets is: every day three times, each 4-6 sheet, and warm water takes, 5 days courses for the treatment of.
embodiment 5the Chinese medicine preparation for the treatment of pneumonia, is prepared from by following bulk drugs, is weight portion (55g/ part): Radix Platycodonis 21.5 parts; Herba Dracocephali Integrifolii 17 parts; Herba Schizonepetae 12 parts; Herba Cirrohopetali Andersonii 12 parts; Semen Raphani 17 parts; Herba Scutellariae indicae 12 parts; Fresh Rhizoma Phragmitis 12 parts; Buttonbush 13.5 parts; Radix Adenophorae Trachelioidis 12.5 parts; Herbia Wedeliae 12 parts; Herba Canscorae 14 parts; Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 13 parts; Fructus Trichosanthis 17.5 parts; Habenria petelotii Gagnep. 12.5 parts; Radix Bupleuri 19 parts; Semen Coicis 21 parts.
The preparation method of the Chinese medicine decoction of above-mentioned treatment pneumonia is:
(1) get new fresh Rhizoma Phragmitis and smash juice, juice is for subsequent use; Semen Coicis rubs, and is placed in non iron container, adds the pure water slow fire boiling 20 minutes of 4.5 times of material quantities, filters, stays decoction for subsequent use;
(2) surplus stock medicine is together placed in Chinese medicinal pot, adds clear water and do not have powder 3-5cm, soak 3.5 hours, then big fire is heated to boil, and turns little fire and decocts twice, respectively decoct 55 minutes at every turn, filter, merge twice decocting liquid; Medicinal residues add the clear water of 3 times amount again, and little fire decocts 25 minutes, and filter, filtrate and decocting liquid merge;
(3) step (2) gained decocting liquid is evaporated to 1/4 of original volume, adds step (1) gained pharagmitis rhizoma juice and Yiyiren Decoction while hot, stir, 103 DEG C of dry heat sterilizations 18 minutes, encapsulation, to obtain final product.
The instructions of taking of decoction of the present invention is: once a day, each 180-200mL, warmly takes, 5 days courses for the treatment of.
test example 1the clinical practice of the Chinese medicine preparation (embodiment 5) of gained treatment pneumonia of the present invention:
1 data and method
1.1 physical data
In June, 2010 in December ,-2013, the patients with pneumonia of accepting for medical treatment at 4 hospital's Pneumology Department is totally 319 examples, wherein male patient 163 example, female patient 156 example, max age 73 years old, minimal ages 8 years old, 35.5 years old mean age.Patient chief complaint is based on heating, cough, tachypnea, flaring of nares.
1.2 diagnosis basis
Symptom and sign: onset is comparatively anxious, has the symptoms such as heating, cough, tachypnea, flaring of nares, rale; When being in a bad way, high heat is persistent, and dyspnea with rapid and short breath is uneasy, and agitation is not peaceful, and complexion is greyish white; There is middle fine rales in pulmonary, normal companion's dry rale or tubular breath sound.
Lab testing: (1) hemogram: bacterial total white blood cells increases, classification neutrophilic leukocytosis; Viral person's numeration of leukocyte reduces.(2) x-ray inspection: pulmonary's exhibit textural increases, disorderly, bright degree reduces, or the fuzzy shadow slightly high in density.
1.3 Therapeutic Method
All patients are divided into experimental group and matched group at random, and two groups of patients, in age, the state of an illness etc., through statistical procedures no significant difference (P > 0.05), have comparability.Wherein experimental group uses gained of the present invention to treat the Chinese medicine preparation of pneumonia, using method: once a day, each 180-200mL, warmly takes, 5 days courses for the treatment of.Observe two courses for the treatment of of treatment altogether.Matched group uses other drug medicines such as () granule as peaceful in lung, lung-clearing anti-inflammatory ball and Cefixime Capsules.
1.4 curative effect determinate standard
Judge with reference to " new Chinese medicine guideline of clinical investigations " relevant criterion.
Cure: after treatment, body temperature is normal, and cough and asthma is alleviated, and pulmonary's moist rales disappears substantially, and x-ray pulmonary shadow disappears; Effective: after treatment, temperature decline, cough is alleviated, and tachypnea obviously alleviates, pulmonary rale reduce or respiratory murmur greatly thicker, x-ray pulmonary shadow absorbs and takes a turn for the better; Invalid: symptom and sign without significant change, or increase the weight of than before treatment.(total effective rate=cure rate+obvious effective rate)
1.5 therapeutic outcome
Result is as shown in table 1.
Table 1: the therapeutic outcome of experimental group and matched group
Therapeutic effect: experimental group total effective rate is 98.6%, and matched group total effective rate is 81.7%.It can thus be appreciated that experimental group successful is better than matched group.
The present invention by Radix Platycodonis, Herba Dracocephali Integrifolii, Herba Schizonepetae, Herba Cirrohopetali Andersonii, Semen Raphani, Herba Scutellariae indicae, fresh Rhizoma Phragmitis, buttonbush, Radix Adenophorae Trachelioidis, Herbia Wedeliae, Herba Canscorae, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Fructus Trichosanthis, Habenria petelotii Gagnep., Radix Bupleuri and Semen Coicis totally 16 taste primary raw material medicines be prepared from.Fang Zhong, Radix Platycodonis has lung qi dispersing, sore-throat relieving, eliminates the phlegm, effect of evacuation of pus; Herba Dracocephali Integrifolii function cures mainly cough-relieving, eliminates the phlegm, relievings asthma; Herba Schizonepetae induces sweat loose wind; Herba Cirrohopetali Andersonii is controlled cough and is spitted blood, rheumatic arthralgia; Semen Raphani therapeutic method to keep the adverse QI flowing downwards Dingchuan, eliminates indigestion and phlegm; Herba Scutellariae indicae dispels the wind, and invigorates blood circulation, removing toxic substances, pain relieving; Fresh Rhizoma Phragmitis heat clearing away, promotes the production of body fluid, relieving restlessness, preventing or arresting vomiting; Buttonbush heat-clearing and toxic substances removing, eliminating stasis to stop pain, hemostasia and promoting granulation, expelling phlegm for arresting cough; Radix Adenophorae Trachelioidis moistening the lung and resolving the phlegm, heat-clearing and toxic substances removing; Herbia Wedeliae heat clearing away, removing toxic substances, blood stasis dispelling, detumescence; Herba Canscorae heat-clearing and toxic substances removing, promoting blood circulation and stopping pain, Semen Coicis spleen invigorating, tonifying the lung, heat clearing away, dampness removing.All medicine compatibilities, bring out the best in each other, and play the merit of invigorating spleen to remove dampness, removing heat-phlegm altogether.After treating two courses for the treatment of, experimental group total effective rate is 98.6%, evident in efficacy.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat the Chinese medicine preparation of pneumonia, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Platycodonis 19-24; Herba Dracocephali Integrifolii 14-20; Herba Schizonepetae 9-15; Herba Cirrohopetali Andersonii 8-16; Semen Raphani 15-19; Herba Scutellariae indicae 9-15; Fresh Rhizoma Phragmitis 8-16; Buttonbush 11-16; Radix Adenophorae Trachelioidis 9-16; Herbia Wedeliae 8-16; Herba Canscorae 12-16; Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 9-17; Fructus Trichosanthis 15-20; Habenria petelotii Gagnep. 10-15; Radix Bupleuri 15-23; Semen Coicis 17-25.
2. the Chinese medicine preparation for the treatment of pneumonia as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Platycodonis 21-22; Herba Dracocephali Integrifolii 16-18; Herba Schizonepetae 11-13; Herba Cirrohopetali Andersonii 10-14; Semen Raphani 16-18; Herba Scutellariae indicae 11-13; Fresh Rhizoma Phragmitis 10-14; Buttonbush 13-14; Radix Adenophorae Trachelioidis 11-14; Herbia Wedeliae 10-14; Herba Canscorae 13-15; Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 12-14; Fructus Trichosanthis 16-19; Habenria petelotii Gagnep. 11-14; Radix Bupleuri 17-21; Semen Coicis 19-23.
3. the Chinese medicine preparation for the treatment of pneumonia as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Platycodonis 21.5; Herba Dracocephali Integrifolii 17; Herba Schizonepetae 12; Herba Cirrohopetali Andersonii 12; Semen Raphani 17; Herba Scutellariae indicae 12; Fresh Rhizoma Phragmitis 12; Buttonbush 13.5; Radix Adenophorae Trachelioidis 12.5; Herbia Wedeliae 12; Herba Canscorae 14; Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 13; Fructus Trichosanthis 17.5; Habenria petelotii Gagnep. 12.5; Radix Bupleuri 19; Semen Coicis 21.
4. the Chinese medicine preparation of the treatment pneumonia as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable decoction, preparation method is as follows:
(1) get new fresh Rhizoma Phragmitis and smash juice, juice is for subsequent use; Semen Coicis rubs, and is placed in non iron container, adds pure water (preferably adding the pure water of the 4.5 times of material quantities) slow fire boiling 20 minutes of 3-6 times of material quantity, filters, stays decoction for subsequent use;
(2) surplus stock medicine is together placed in Chinese medicinal pot, adds clear water and do not have powder 3-5cm, soak 2-5 hour, then big fire is heated to boil, and turns little fire and decocts twice, respectively decocts 50-60 minute (preferably each respectively decoction 55 minutes) at every turn, filter, merge twice decocting liquid; Medicinal residues add the clear water of 3 times amount again, and little fire decocts 15-35 minute (preferred little fire decocts 25 minutes), and filter, filtrate and decocting liquid merge;
(3) step (2) gained decocting liquid is evaporated to 1/4 of original volume, adds step (1) gained pharagmitis rhizoma juice and Yiyiren Decoction while hot, stir, dry heat sterilization, encapsulation, to obtain final product.
5. the preparation method of the Chinese medicine decoction for the treatment of pneumonia according to claim 4, is characterized in that, step (2) is soaked 3-4 hour (preferably soaking 3.5 hours).
6. the preparation method of the Chinese medicine decoction for the treatment of pneumonia according to claim 4, it is characterized in that, in step (3), the temperature of dry heat sterilization is 96-110 DEG C (temperature of preferred dry heat sterilization is 100-106 DEG C, and the temperature of the dry heat sterilization be more preferably is 103 DEG C).
7. the preparation method of the Chinese medicine decoction for the treatment of pneumonia according to claim 4, it is characterized in that, in step (3), the time of dry heat sterilization is 12-24 minute (time of preferred dry heat sterilization is 16-20 minute, and the time of the dry heat sterilization be more preferably is 18 minutes).
8. the Chinese medicine preparation of the treatment pneumonia as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable thick paste agent, preparation method is as follows:
(1) Radix Platycodonis, Semen Raphani, buttonbush, Radix Adenophorae Trachelioidis, Fructus Trichosanthis and Radix Bupleuri are placed in Chinese medicine air drier, in 65-85 DEG C of dry 1-1.4 hour (being preferable over 75 DEG C of dryings 1.2 hours), taking out, be ground into fine powder, for subsequent use; Semen Coicis is ground into powder, for subsequent use;
(2) by step (1) gained medicated powder, mixing, sieves, obtains mixing fine powders for subsequent use; New fresh Rhizoma Phragmitis smashes juice, and taking juice is for subsequent use;
(3) Herba Dracocephali Integrifolii, Herba Schizonepetae, Herba Cirrohopetali Andersonii, Herba Scutellariae indicae, Herbia Wedeliae, Herba Canscorae, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. and Habenria petelotii Gagnep. are placed in Chinese medicinal pot, add the clear water (preferably adding the clear water of 7 times of material quantities) of 6-8 times of material quantity, slow fire boiling twice, each respectively decoction 45-65 minute (preferably each each decoction 55 minutes), filter, merge twice decocting liquid;
(4) in above-mentioned decocting liquid, add step (2) gained mixing fine powders and pharagmitis rhizoma juice, continue slow fire boiling 20-30 minute (preferably continuing slow fire boiling 25 minutes), filter, filtrate reduced in volume to 80 DEG C relative density is the thick paste of 1.31-1.33, sterilizing, encapsulation, to obtain final product.
9. the Chinese medicine preparation of the treatment pneumonia as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable capsule, preparation method is: pulverized by each crude drug, cross 90-130 mesh sieve (preferred mistake 110 mesh sieve), according to 0.25-0.45g/ grain (preferred 0.35g/ grain) metering, be processed into capsule shape dosage form according to the preparation for processing of capsule.
10. the Chinese medicine preparation of the treatment pneumonia as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable tablet, preparation method is as follows:
(1) take various crude drug by formula proportion, dry, grind into powder, cross 100-140 mesh sieve (preferred mistake 120 mesh sieve), obtain mixed powder;
(2) above-mentioned medicated powder is measured according to 0.3-0.5g/ sheet (preferably according to 0.4g/ sheet), make tablet dosage form according to the preparation for processing of tablet.
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| CN107617043A (en) * | 2017-10-29 | 2018-01-23 | 杨小丽 | A kind of medicine for treating lobar pneumonia and preparation method thereof |
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