CN104306817A - Pharmaceutical composition for treating ephemeral fever of dairy cow and preparation method thereof - Google Patents

Pharmaceutical composition for treating ephemeral fever of dairy cow and preparation method thereof Download PDF

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CN104306817A
CN104306817A CN201410579083.4A CN201410579083A CN104306817A CN 104306817 A CN104306817 A CN 104306817A CN 201410579083 A CN201410579083 A CN 201410579083A CN 104306817 A CN104306817 A CN 104306817A
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pharmaceutical composition
herba
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翟桂玉
姜慧新
仲崇岳
刘栋
王兆凤
曹阳
陈国强
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61K36/11—Pteridophyta or Filicophyta (ferns)
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Abstract

The invention discloses a pharmaceutical composition for treating ephemeral fever of dairy cow and a preparation method thereof. The pharmaceutical composition is prepared from the following medicinal raw materials: coptis chinensis, houttuynia cordata, scutellariae barbatae, trollius chinensis bunge, dysosma versipelis, lygodium japonicum, chrysanthemum, ficus tikoua, large-leaved gentian, smilax china, dried tangerine peel, astragalus membranaceus, exocarpium benincasae, apocynum venetum, rohdea japonica, camellia sinensis, magnolia officinalis, Chinese yam, polygonum persicaria, panax ginseng fruit and hawthorns. The pharmaceutical composition has main effects of clearing heat, removing toxicity, dispelling wind and drying dampness, also has the effects of strengthening heart, inducing diuresis, tonifying spleen, strengthening stomach, tonifying and tranquilizing, and has the advantages of good effect of treating ephemeral fever of dairy cow, effective prevention, no toxic or side effect and no drug residue.

Description

Be used for the treatment of pharmaceutical composition of milk Bovine Ephemeral Fever and preparation method thereof
 
Technical field
The present invention relates to the technical field of animal feed, additive, particularly relate to and be a kind ofly used for the treatment of pharmaceutical composition of milk Bovine Ephemeral Fever and preparation method thereof.
 
Background technology
Bovine Ephemeral Fever (having another name called Ephemeral fever) is a kind of acute febrile infectious disease caused by Rhabdoviridae bovine epizootic fever virus.It is characterized by high heat suddenly, tachypnea, sheds tears and Alimentary serious mucositis inflammation and the dyskinesia.Namely the sick cattle of major part infecting primary disease recovered normal through 2 ~ 3, therefore also known as Ephemeral fever or temporarily hot.Primary disease patient's condition is swift and violent, but mostly is optimum process.This disease mainly encroaches on cattle, cattle, milk cattle, Babalus bubalis L. all can infection morbidity.With 3 years old ~ 5 years old prime of life cattle, milk cattle, cattle susceptibility be maximum.Babalus bubalis L. and calf fall ill less.This condition of disease causes Niu great Qun to fall ill, and obviously reduces the milk production of milch cow.
Primary disease is popular has obvious seasonality, multiple June ~ JIUYUE of being born in the many and hot climate of rainfall.Rapidly popular, large quantities of cattle can be made in a short time only to fall ill, in endemicity or large fluidity.Popular upper some cycles in addition.Within about 3 years ~ 5 years, be very popular once.Sick cattle mostly is optimum process, and when not having secondary infection, mortality rate is 1% ~ 3%.Incubation period is 3 days ~ 7 days.
Cardinal symptom has the following aspects: at the beginning of (1) disease, ill domestic animal trembles, shivering, and then body temperature is elevated to more than 40 DEG C, delays temperature recovery after 2 days ~ 3 days normal.While body temperature raises, shed tears as seen, have water sample eye secretion, eyelid, conjunctival congestion, edema.Tachypnea, frequency of respiration is per minute reaches more than 80 times, dyspnea, suffers from poultry and emits moans, in depressed shape.At this moment owing to there occurs interstitial emphysema, sometimes can die by being choked to death.(2) appetite is absolutely useless, ruminates stopping.First stomach is wriggled and is stopped, and occur tympanites or lack moisture, gastric content dries up.Feces is dry, dysentery sometimes.Extremities joint edema pain, sick cattle is slow-witted vertical, walks lamely, later dysstasia and lying prostrate.(3) Pi Wen is not whole, and particularly angle root, earflap, acra have creeping chill.In addition, visible subcutaneous emphysema under jaw.Stream nose liquid, stomatitis, significantly flows birth.Bicker has foam.Hypourocrinia, Cloudy Urine.Milk production of cow obviously declines, and even lactogenic stops.
Cut open inspection change and be mainly pulmonary's change, lung high level expansion, interstitial is broadening, inside has bubble, pressing lung is crepitation, and tunicle swells, and has egg to arrive greatly the protuberance air bag of fist size under tunicle, lung parenchyma tissue forms space, and trachea inner product has volume spumescence mucus, mucosa hemorrhage.Lymph nodes of body as a whole swelling, fourth stomach and caecum mucosa have petechia, pericardial effusion.
At present, western medical treatment milk Bovine Ephemeral Fever, effect is unsatisfactory, and curative effect is single, has drug residue, and side effect is larger, and can only suit the remedy to the case after being ill, and more effective prophylactic agent.
 
Summary of the invention
Technical problem to be solved by this invention be to provide a kind of can therapeutic effect good and can effectively prevent, have no side effect and drug residue be used for the treatment of Chinese medicine composition of milk Bovine Ephemeral Fever and preparation method thereof.
In order to be realize foregoing invention object, the invention provides a kind of pharmaceutical composition being used for the treatment of milk Bovine Ephemeral Fever, it is characterized in that, described pharmaceutical composition comprises following raw medicinal material: Rhizoma Coptidis, Herba Houttuyniae, Herba Scutellariae Barbatae, Flos Trollii, Radix et Rhizoma Dysosmatis, Spora Lygodii, Flos Chrysanthemi, Caulis et Folium fici Tikouae, Radix Gentianae Macrophyllae, Rhizoma Smilacis Chinensis, Exocarpium Citri Rubrum, the Radix Astragali, Exocarpium Benincasae, Herba Apocyni veneti, Rohdea japonica Roth, Radix Camelliae sinensis, Cortex Magnoliae Officinalis, Rhizoma Dioscoreae, red shank, Herba Herminii and Fructus Crataegi.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Rhizoma Coptidis 5-13 weight portion, Herba Houttuyniae 10-25 weight portion, Herba Scutellariae Barbatae 11-17 weight portion, Flos Trollii 10-20 weight portion, Radix et Rhizoma Dysosmatis 5-13 weight portion, Spora Lygodii 5-11 weight portion, Flos Chrysanthemi 13-22 weight portion, Caulis et Folium fici Tikouae 8-15 weight portion, Radix Gentianae Macrophyllae 5-15 weight portion, Rhizoma Smilacis Chinensis 5-10 weight portion, Exocarpium Citri Rubrum 8-16 weight portion, Radix Astragali 5-9 weight portion, Exocarpium Benincasae 11-18 weight portion, Herba Apocyni veneti 3-7 weight portion, Rohdea japonica Roth 3-7 weight portion, Radix Camelliae sinensis 10-17 weight portion, Cortex Magnoliae Officinalis 15-20 weight portion, Rhizoma Dioscoreae 15-22 weight portion, red shank 5-15 weight portion, Herba Herminii 7-15 weight portion and Fructus Crataegi 5-13 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Rhizoma Coptidis 8 weight portion, Herba Houttuyniae 17 weight portion, Herba Scutellariae Barbatae 14 weight portion, Flos Trollii 15 weight portion, Radix et Rhizoma Dysosmatis 7 weight portion, Spora Lygodii 7 weight portion, Flos Chrysanthemi 19 weight portion, Caulis et Folium fici Tikouae 11 weight portion, Radix Gentianae Macrophyllae 9 weight portion, Rhizoma Smilacis Chinensis 8 weight portion, Exocarpium Citri Rubrum 12 weight portion, the Radix Astragali 7 weight portion, Exocarpium Benincasae 15 weight portion, Herba Apocyni veneti 5 weight portion, Rohdea japonica Roth 5 weight portion, Radix Camelliae sinensis 14 weight portion, Cortex Magnoliae Officinalis 18 weight portion, Rhizoma Dioscoreae 19 weight portion, red shank 11 weight portion, Herba Herminii 11 weight portion and Fructus Crataegi 9 weight portion.
Described pharmaceutical composition also comprises: Ganoderma, Fructus Jujubae, Semen Ziziphi Spinosae, Fructus Fici Heteromo, Semen Abutili and Fructus Lycii, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Rhizoma Coptidis 5-13 weight portion, Herba Houttuyniae 10-25 weight portion, Herba Scutellariae Barbatae 11-17 weight portion, Flos Trollii 10-20 weight portion, Radix et Rhizoma Dysosmatis 5-13 weight portion, Spora Lygodii 5-11 weight portion, Flos Chrysanthemi 13-22 weight portion, Caulis et Folium fici Tikouae 8-15 weight portion, Radix Gentianae Macrophyllae 5-15 weight portion, Rhizoma Smilacis Chinensis 5-10 weight portion, Exocarpium Citri Rubrum 8-16 weight portion, Radix Astragali 5-9 weight portion, Exocarpium Benincasae 11-18 weight portion, Herba Apocyni veneti 3-7 weight portion, Rohdea japonica Roth 3-7 weight portion, Radix Camelliae sinensis 10-17 weight portion, Cortex Magnoliae Officinalis 15-20 weight portion, Rhizoma Dioscoreae 15-22 weight portion, red shank 5-15 weight portion, Herba Herminii 7-15 weight portion, Fructus Crataegi 5-13 weight portion, Ganoderma 10-20 weight portion, Fructus Jujubae 8-12 weight portion, Semen Ziziphi Spinosae 7-15 weight portion, Fructus Fici Heteromo 5-12 weight portion, Semen Abutili 8-15 weight portion and Fructus Lycii 5-12 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Rhizoma Coptidis 8 weight portion, Herba Houttuyniae 17 weight portion, Herba Scutellariae Barbatae 14 weight portion, Flos Trollii 15 weight portion, Radix et Rhizoma Dysosmatis 7 weight portion, Spora Lygodii 7 weight portion, Flos Chrysanthemi 19 weight portion, Caulis et Folium fici Tikouae 11 weight portion, Radix Gentianae Macrophyllae 9 weight portion, Rhizoma Smilacis Chinensis 8 weight portion, Exocarpium Citri Rubrum 12 weight portion, the Radix Astragali 7 weight portion, Exocarpium Benincasae 15 weight portion, Herba Apocyni veneti 5 weight portion, Rohdea japonica Roth 5 weight portion, Radix Camelliae sinensis 14 weight portion, Cortex Magnoliae Officinalis 18 weight portion, Rhizoma Dioscoreae 19 weight portion, red shank 11 weight portion, Herba Herminii 11 weight portion, Fructus Crataegi 9 weight portion, Ganoderma 15 weight portion, Fructus Jujubae 11 weight portion, Semen Ziziphi Spinosae 11 weight portion, Fructus Fici Heteromo 9 weight portion, Semen Abutili 11 weight portion and Fructus Lycii 8 weight portion.
In order to better realize foregoing invention object, the invention provides a kind of preparation method being used for the treatment of the pharmaceutical composition of milk Bovine Ephemeral Fever, when the dosage form of described pharmaceutical composition is powder, its preparation method is:
The first step: described raw medicinal material is mixed in proportion, drop into pulverizer to carry out pulverizing or directly shredding, load and decoct in container, add 2-3 times of water gaging and make its submergence medical material, soak after 10-25 minute, be heated to boiling after 40-70 minute, be separated fried liquid, medicinal residues again add water and carry out decoction 2-3 time, the fried liquid that separated and collected is each, again after filtering, get filtrate and abandon filtering residue;
Second step: after liquid cooling but to be filtered, adding relative to concentrated rear liquid weight 1-2 determining alcohol is doubly 80-90% ethanol, abundant mix homogeneously, placement is spent the night, and makes it precipitate, and obtains filtrate after getting its supernatant liquid filtering next day, precipitate determining alcohol is that the ethanol of 50-60% is cleaned, and collects washing liquid and merges with filtrate, after ethanol is regained in decompression, dislocation lets cool place, leave standstill 0.5-1 hour, make precipitation complete, filter, filtrate low-temperature evaporation, obtains paste;
3rd step: paste is put into spray dryer dry, ensure that inlet temperature is at 180 DEG C-200 DEG C, leaving air temp 70 DEG C-90 DEG C, is ground into 300 order-400 orders subsequently, obtains Chinese powder medicine.
When the dosage form of described pharmaceutical composition is injection, its preparation method is:
The first step, takes all raw medicinal materials according to ratio of weight and number, co-grinding, decoct with water 2 ~ 4 times, each decocting time is 2 ~ 3 hours, and the water quality added is 2 ~ 4 times of first step mixture quality, merge decoction liquor, filter, filtrate is concentrated into syrupy shape, adds the ethanol that determining alcohol is more than 95%, the ethanol content added is 1 ~ 2 times of the mixture quality of the first step, leave standstill after 12 hours ~ 24 hours, centrifugal filtration, filtrate is adjusted to filtrate pH7 ~ 8 with the NaOH of 40% ~ 50%;
Second step, by the filtrate that the first step obtains, adds 0.5% ~ 1% active carbon and boils 18 ~ 22 minutes, filters, decarburization, injects with water, makes the crude drug concentration of injection be 2 ~ 4g/ml, fill sterilizing 1.5 hours ~ 2 hours in 500ml saline bottle, after freezing a couple of days, filters.
 
Preferably, present invention also offers a kind of milk cow forage being used for the treatment of milk Bovine Ephemeral Fever, described feedstuff comprises following raw material: the cabbage leaves of Semen Maydis, bean cake, corn straw, Pericarppium arachidis hypogaeae, Semen arachidis hypogaeae dregs, corn germ cake, Semen Vitis viniferae, Retinervus Luffae Fructus, bagasse, oven dry, spray-dried plasma protein, glucose, mixed active bacterium liquid, microelement pre-mix material, vitamin premix and Chinese medicine additive;
In described feedstuff, the parts by weight of each raw material are: Semen Maydis 30-50 weight portion, bean cake 10-30 weight portion, corn straw 10-20 weight portion, Pericarppium arachidis hypogaeae 8-21 weight portion, Semen arachidis hypogaeae dregs 15-20 weight portion, corn germ cake 5-10 weight portion, Semen Vitis viniferae 3-8 weight portion, Retinervus Luffae Fructus 5-8 weight portion, bagasse 3-7 weight portion, the cabbage leaves 2-9 weight portion of drying, spray-dried plasma protein 1-5 weight portion, glucose 2-4 weight portion, mixed active bacterium liquid 1-4 weight portion, Sal 1-2 weight portion, soybean oil 1-3 weight portion, microelement pre-mix material 0.1-2 weight portion and Chinese medicine additive 3-7 weight portion.
In described feedstuff, the parts by weight of each raw material are: Semen Maydis 45 weight portion, bean cake 18 weight portion, corn straw 14 weight portion, Pericarppium arachidis hypogaeae 16 weight portion, Semen arachidis hypogaeae dregs 17 weight portion, corn germ cake 8 weight portion, Semen Vitis viniferae 6 weight portion, Retinervus Luffae Fructus 6 weight portion, bagasse 5 weight portion, cabbage leaves 5 weight portion of drying, spray-dried plasma protein 3 weight portion, glucose 3 weight portion, mixed active bacterium liquid 3 weight portion, Sal 2 weight portion, soybean oil 2 weight portion, microelement pre-mix material 0.8 weight portion and Chinese medicine additive 5 weight portion.
Wherein, described mixed active bacterium liquid is one or both in lactobacillus and bacillus bifidus; Described microelement pre-mix material is one or more in copper, ferrum, manganese, zinc, iodine, selenium.
In described Chinese medicine additive, the parts by weight of each raw medicinal material are: Rhizoma Coptidis 5-13 weight portion, Herba Houttuyniae 10-25 weight portion, Herba Scutellariae Barbatae 11-17 weight portion, Flos Trollii 10-20 weight portion, Radix et Rhizoma Dysosmatis 5-13 weight portion, Spora Lygodii 5-11 weight portion, Flos Chrysanthemi 13-22 weight portion, Caulis et Folium fici Tikouae 8-15 weight portion, Radix Gentianae Macrophyllae 5-15 weight portion, Rhizoma Smilacis Chinensis 5-10 weight portion, Exocarpium Citri Rubrum 8-16 weight portion, Radix Astragali 5-9 weight portion, Exocarpium Benincasae 11-18 weight portion, Herba Apocyni veneti 3-7 weight portion, Rohdea japonica Roth 3-7 weight portion, Radix Camelliae sinensis 10-17 weight portion, Cortex Magnoliae Officinalis 15-20 weight portion, Rhizoma Dioscoreae 15-22 weight portion, red shank 5-15 weight portion, Herba Herminii 7-15 weight portion, Fructus Crataegi 5-13 weight portion, Ganoderma 10-20 weight portion, Fructus Jujubae 8-12 weight portion, Semen Ziziphi Spinosae 7-15 weight portion, Fructus Fici Heteromo 5-12 weight portion, Semen Abutili 8-15 weight portion and Fructus Lycii 5-12 weight portion.
In described Chinese medicine additive, the parts by weight of each raw medicinal material are preferably: Rhizoma Coptidis 8 weight portion, Herba Houttuyniae 17 weight portion, Herba Scutellariae Barbatae 14 weight portion, Flos Trollii 15 weight portion, Radix et Rhizoma Dysosmatis 7 weight portion, Spora Lygodii 7 weight portion, Flos Chrysanthemi 19 weight portion, Caulis et Folium fici Tikouae 11 weight portion, Radix Gentianae Macrophyllae 9 weight portion, Rhizoma Smilacis Chinensis 8 weight portion, Exocarpium Citri Rubrum 12 weight portion, the Radix Astragali 7 weight portion, Exocarpium Benincasae 15 weight portion, Herba Apocyni veneti 5 weight portion, Rohdea japonica Roth 5 weight portion, Radix Camelliae sinensis 14 weight portion, Cortex Magnoliae Officinalis 18 weight portion, Rhizoma Dioscoreae 19 weight portion, red shank 11 weight portion, Herba Herminii 11 weight portion, Fructus Crataegi 9 weight portion, Ganoderma 15 weight portion, Fructus Jujubae 11 weight portion, Semen Ziziphi Spinosae 11 weight portion, Fructus Fici Heteromo 9 weight portion, Semen Abutili 11 weight portion and Fructus Lycii 8 weight portion.
The preparation method of described Chinese medicine additive is:
The first step: described raw medicinal material is mixed in proportion, drop into pulverizer to carry out pulverizing or directly shredding, load and decoct in container, add 2-3 times of water gaging and make its submergence medical material, soak after 10-25 minute, be heated to boiling after 40-70 minute, be separated fried liquid, medicinal residues again add water and carry out decoction 2-3 time, the fried liquid that separated and collected is each, again after filtering, get filtrate and abandon filtering residue;
Second step: after liquid cooling but to be filtered, adding relative to concentrated rear liquid weight 1-2 determining alcohol is doubly 80-90% ethanol, abundant mix homogeneously, placement is spent the night, and makes it precipitate, and obtains filtrate after getting its supernatant liquid filtering next day, precipitate determining alcohol is that the ethanol of 50-60% is cleaned, and collects washing liquid and merges with filtrate, after ethanol is regained in decompression, dislocation lets cool place, leave standstill 0.5-1 hour, make precipitation complete, filter, filtrate low-temperature evaporation, obtains paste;
3rd step: paste is put into spray dryer dry, ensure that inlet temperature is at 180 DEG C-200 DEG C, leaving air temp 70 DEG C-90 DEG C, is ground into 300 order-400 orders subsequently, obtains Chinese powder medicine.
The preparation method of described feedstuff is:
(1) by weight the cabbage leaves mixing of Semen Maydis in above-mentioned raw materials, bean cake, corn straw, Pericarppium arachidis hypogaeae, Semen arachidis hypogaeae dregs, corn germ cake, Semen Vitis viniferae, Retinervus Luffae Fructus, bagasse and oven dry is ground, add water dilution 2-4 mixed active bacterium liquid doubly, sealing and fermenting after stirring, control temperature is at 25-35 DEG C, and ferment the compound that must ferment for 3-6 hour;
(2) mixed with other raw materials by above-mentioned fermentation compound, temperature is dried under 30-40 DEG C of condition, pulverizes 60 mesh sieves.
 
Preferably, present invention also offers a kind of Traditional Chinese medicinal spray being used for the treatment of milk Bovine Ephemeral Fever, described Traditional Chinese medicinal spray comprises following raw medicinal material: Rhizoma Coptidis, Herba Scutellariae Barbatae, Flos Chrysanthemi, Caulis et Folium fici Tikouae, Exocarpium Citri Rubrum, Ganoderma, Semen Arecae, Herba Menthae, Borneolum Syntheticum, Herba Pogostemonis and Pyrethrum.
In described Traditional Chinese medicinal spray, the parts by weight of each raw medicinal material are: Rhizoma Coptidis 20-30 weight portion, Herba Scutellariae Barbatae 17-25 weight portion, Flos Chrysanthemi 5-17 weight portion, Caulis et Folium fici Tikouae 6-10 weight portion, Exocarpium Citri Rubrum 7-13 weight portion, Ganoderma 6-12 weight portion, Semen Arecae 3-9 weight portion, Herba Menthae 2-6 weight portion, Borneolum Syntheticum 1-3 weight portion, Herba Pogostemonis 1-5 weight portion and Pyrethrum 1-3 weight portion.
In described Traditional Chinese medicinal spray, the parts by weight of each raw medicinal material are preferably: Rhizoma Coptidis 27 weight portion, Herba Scutellariae Barbatae 21 weight portion, Flos Chrysanthemi 9 weight portion, Caulis et Folium fici Tikouae 8 weight portion, Exocarpium Citri Rubrum 11 weight portion, Ganoderma 9 weight portion, Semen Arecae 5 weight portion, Herba Menthae 4 weight portion, Borneolum Syntheticum 2 weight portion, Herba Pogostemonis 2 weight portion and Pyrethrum 2 weight portion.
The preparation method of described Traditional Chinese medicinal spray is:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour;
Step 2: be placed in by purple casserole on fire, after intense fire boils, uses slow fire instead and decocts 30-50 minute slowly, filters, obtains filtrate a, for subsequent use;
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour;
Step 4: be placed in by purple casserole on fire, after intense fire boils, uses slow fire instead and decocts 25-35 minute slowly, filters, obtains filtrate b, mixed by filtrate a and filtrate b.
During use, Traditional Chinese medicinal spray clear water dilution 5-10 doubly can be sprayed, not only there is the effect of cooling, also there is the effect for the treatment of Bovine Ephemeral Fever and control infection.
 
The beneficial effect that technical scheme of the present invention is brought is: Chinese medicine composition of the present invention is based on heat-clearing and toxic substances removing, expelling wind and removing dampness, to hold concurrently heart tonifying diuresis, spleen reinforcing stomach invigorating, invigorating QI and tranquilization, have effective at treatment Bovine Ephemeral Fever and effectively can prevent, have no side effect and the advantage of drug residue; Wherein, present invention also offers a kind of feedstuff containing Chinese medicine additive and can not only treat Bovine Ephemeral Fever, but also the nutritional need of ill milch cow can be met, improve the milk yield of milch cow; Present invention also offers a kind of Traditional Chinese medicinal spray that there is treatment Bovine Ephemeral Fever and control infection, there is effect that heat-clearing and toxic substances removing, expelling wind and removing dampness, dispelling wind-heat and anthelmintic sterilize.
 
Detailed description of the invention
Chinese veterinarian thinks, the friendship in the autumn in summer that Bovine Ephemeral Fever is fallen ill higher in temperature, cloudy and drizzly for days on end, and moist mistake is contained, weather is not normal, temperature Change is larger, daytime is damp and hot, and evening is cold, adds mismanagement, forced labour is overweight, positive QI-insufficiency, system is not good for, and wind, cold, summer-heat, wet heresy easily invade body, multiple abscess in meridians, coagulation of QI-blood and primary disease occurs.The invention provides a kind of Chinese medicine composition being used for the treatment of Bovine Ephemeral Fever, based on heat-clearing and toxic substances removing, expelling wind and removing dampness, hold concurrently heart tonifying diuresis, spleen reinforcing stomach invigorating, invigorating QI and tranquilization, yin nourishing; It comprises Rhizoma Coptidis, Herba Houttuyniae, Herba Scutellariae Barbatae, Flos Trollii, Radix et Rhizoma Dysosmatis, Spora Lygodii, Flos Chrysanthemi, Caulis et Folium fici Tikouae, Radix Gentianae Macrophyllae, Rhizoma Smilacis Chinensis, Exocarpium Citri Rubrum, the Radix Astragali, Exocarpium Benincasae, Herba Apocyni veneti, Rohdea japonica Roth, Radix Camelliae sinensis, Cortex Magnoliae Officinalis, Rhizoma Dioscoreae, red shank, Herba Herminii and Fructus Crataegi; Preferably, Ganoderma, Fructus Jujubae, Semen Ziziphi Spinosae, Fructus Fici Heteromo, Semen Abutili and Fructus Lycii is also comprised; Wherein, Rhizoma Coptidis, Herba Houttuyniae, Herba Scutellariae Barbatae, Flos Trollii, Radix et Rhizoma Dysosmatis, Spora Lygodii, Flos Chrysanthemi have effect of heat-clearing and toxic substances removing; Caulis et Folium fici Tikouae, Radix Gentianae Macrophyllae, Rhizoma Smilacis Chinensis, Exocarpium Citri Rubrum have expelling wind and removing dampness effect; The Radix Astragali, Exocarpium Benincasae, Herba Apocyni veneti, Rohdea japonica Roth, Radix Camelliae sinensis have heart tonifying diuresis effect; Cortex Magnoliae Officinalis, Rhizoma Dioscoreae, red shank, Herba Herminii, Fructus Crataegi have spleen reinforcing stomach invigorating effect; Ganoderma, Fructus Jujubae, Semen Ziziphi Spinosae, Fructus Fici Heteromo, Semen Abutili, Fructus Lycii have effect of invigorating QI and tranquilization, yin nourishing.
Present invention also offers a kind of Traditional Chinese medicinal spray being used for the treatment of Bovine Ephemeral Fever, there is the effect such as heat-clearing and toxic substances removing, expelling wind and removing dampness, comprising: Rhizoma Coptidis, Herba Scutellariae Barbatae, Flos Chrysanthemi, Caulis et Folium fici Tikouae, Exocarpium Citri Rubrum, Ganoderma, Semen Arecae, Herba Menthae, Borneolum Syntheticum, Herba Pogostemonis and Pyrethrum; Wherein, Rhizoma Coptidis, Herba Scutellariae Barbatae, Flos Chrysanthemi have effect of heat-clearing and toxic substances removing; Caulis et Folium fici Tikouae, Exocarpium Citri Rubrum have expelling wind and removing dampness effect; Ganoderma QI invigorating; Semen Arecae, Herba Menthae, Borneolum Syntheticum dispelling wind-heat; Herba Pogostemonis, Pyrethrum anophelifuge.
The pharmacological property of above-mentioned each raw medicinal material is as follows:
Rhizoma Coptidis: bitter in the mouth, cold in nature, enter the heart, lung, gallbladder, stomach, large intestine channel, there is heat clearing and damp drying, eliminating fire and detoxication, the effect of cooling blood for improving eyesight, cure mainly damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, toothache, quench one's thirst, carbuncle furuncle, eczema, eczema, auditory meatus such as to be suppurated at the card, Rhizoma Coptidis is light broad spectrum antiviral drug thing, effectively can reduce the drug resistance of Salmonella, to staphylococcus aureus, blood dissolubility streptococcus, streptococcus pneumoniae, meningococcus, dysentery bacteriums etc. have stronger bacteriostasis, amplification on Canon of Materia Medica: moderns are multiplex controls dysentery, lid is held with the dry justice of hardship.Lower valgar but see that intestinal void is oozed and let out, micro-seemingly have hemafecia, namely with it, only more do not know.Ignore again cold and heat how many, but with most agent for degree, by being cause danger to be stranded more.If QI excess is just sick, overabundant heat dysentery, just stopping of clothes, still need not use up agent also.Or empty and cold, then must not take.Remaining as " warp ".
Herba Houttuyniae: acrid in the mouth, cold nature, enters lung, urinary bladder channel, has heat-clearing and toxic substances removing, removing pus and relieving carbuncle, effect of inducing diuresis for treating stranguria syndrome, and for lung abscess vomiting pus, expectorant heat syndrome cough is breathed heavily, toxic-heat and blood stasis, damp-heat gonorrhoea, pyretic toxicity carbuncle sore, and snakeworm wants first-class card.
Herba Scutellariae Barbatae: micro-hardship is cool.Cure mainly heat clearing away, removing toxic substances, dissipating blood stasis, hemostasis, analgesic therapy, controls haematemesis, epistaxis, stranguria with blood, bloody dysentery, and jaundice is had sore throat, lung abscess, furuncle, scrofula, sore, cancerous protuberance, traumatic injury knife injury, venom.Modern pharmacology research shows that Herba Scutellariae Barbatae has the effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, antitoxin venom.Formula is often made Herba Scutellariae Barbatae and other Chinese herbal medicine by China, and treatment hepatitis and various cancer are as gastric cancer, rectal cancer, pulmonary carcinoma, lymphatic cancer and gynecological tumor etc.
Flos Trollii: bitter, cool.Function cures mainly: heat-clearing and toxic substances removing.For acute and chronic tonsillitis, acute otitis media, acute myringitis, acute conjunctivitis, acute lymphangitis.
Radix et Rhizoma Dysosmatis: sweet, bitter in the mouth is cool.Function cures mainly: heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling.Cure mainly: venom, traumatic injury; Worm venom is controlled in external, and carbuncle furuncle swells, lymphadenitis, parotitis, breast carcinoma.
Spora Lygodii: sweet, salty, cold.Return bladder, small intestine meridian.Function cures mainly: eliminating damp-heat, treating stranguria pain relieving.For pyretic stranguria, sand Stranguria, stranguria caused by urinary stone, stranguria with blood, stranguria marked by chyluria, Urethra astringent pain.
Flos Chrysanthemi: sweet, bitter, is slightly cold.Return lung, Liver Channel.Function cures mainly: loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.
Caulis et Folium fici Tikouae: heat clearing away, dampness removing, invigorates blood circulation, removing toxic substances.Control cough due to pathogenic wind-heat, dysentery, edema, jaundice, rheumatalgia, bleeding hemorrhoids, amenorrhea, leukorrhagia, infantile dyspepsia, traumatic injury, innominate toxic swelling.
Radix Gentianae Macrophyllae: pungent, bitter is flat.Return stomach, liver, gallbladder meridian.Function cures mainly: wind-damp dispelling, clearing away damp-heat, stopping numbness pain.For rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached, afternoon fever, and infantile malnutrition generates heat.
Rhizoma Smilacis Chinensis: sweet, sour, flat.Function cures mainly: expelling wind and removing dampness, removing toxic substances and promoting subsidence of swelling.Root stock: dispelling the wind and dampness pathogens arthralgia, traumatic injury, gastroenteritis, dysentery, dyspepsia, diabetes, chyluria, leucorrhea, cancer; Leaf: carbuncle furuncle furuncle is controlled in external, scalds.
Exocarpium Citri Rubrum: pungent, bitter, temperature.Return lung, spleen channel.Function cures mainly: cold expelling, dampness, promoting the circulation of QI, expectorant.For cough due to wind and cold, itching of the throat abundant expectoration, food stagnation is got sick from drinking too much wine, and vomiting and nausea painful abdominal mass is vexed.
The Radix Astragali: based on tonify deficiency, energy invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Cave in for insufficiency of vital energy and blood, skin infection, difficulty in discharging of pus or burst for a long time and do not hold back person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows, the Radix Astragali includes and multiple antibiotic effective ingredient, and the immunologic function of energy enhancing body, therefore can also be used for the generation preventing some infectious disease." book on Chinese herbal medicine meets former " carries: " all void of Radix Astragali energy tonifying five ZANG-organs, controls stringy pulse spontaneous perspiration, rush down YIN-fire, remove lung-heat, lossless, sends out, and has antiperspirant then to stop." be the good medicine promoting resistance and defence disease.
Exocarpium Benincasae: property is sweet and be slightly cold; Return lung, spleen, small intestine meridian.There is clearing away heat and promoting diuresis; Effect of detumescence.Function cures mainly: edema; Dysuria; Have loose bowels; Skin ulcer swells.Inducing diuresis to remove edema.For edema distension, dysuria, summer-heat is thirsty, oliguria with reddish urine.
Herba Apocyni veneti: sweetness and bitterness is cool." Shaanxi Chinese herbal medicine ": " refrigerant pathogenic fire purging, heart tonifying diuresis, blood pressure lowering.Control heart disease, hypertension, neurasthenia, nephritis edema." relieve inflammation or internal heat, blood pressure lowering, heart tonifying, diuresis.Control heart disease, hypertension, neurasthenia, hepatitis abdominal distention, nephritis edema.In root of Apocynum venetum L., contained cymarin all can make its shrinkage amplitude increase to the cat heart in vitro and in place, heart rate is slack-off, then arrhythmia, finally heart beating stops at systole, its interaction property is similar to strophanthin with speed, and the central depressants such as pentobarbital sodium can weaken its cardiotonic.Cymarin is not enough to the experimental cardiovascular function of dog, and have therapeutical effect, the symptom of the acute circulatory disorder of Rabbit Myocardium inflammation alleviates to some extent, and can prevent cardiac muscle and crown sclerosis of blood vessels, and this effect is excellent compared with strophanthin.
Rohdea japonica Roth: nature and flavor: " book on Chinese herbal medicine is newly organized ": " bitter and puckery flavor, feeble QI is trembled with fear." return through: " book on Chinese herbal medicine newly organized ": " enters kidney channel, specially logically appoints an arteries and veins of superintending and directing, and also can enter lung." cure mainly: heart tonifying diuresis, heat-clearing and toxic substances removing, hemostasis.Control heart failure, laryngopharynx swelling and pain, spitting of blood, spit blood, sore, venom.1. " book on Chinese herbal medicine is newly organized ": " kill consumptive disease worm, black beard and hair." 2. " BAICAO mirror ": " is decocted and is washed furunculosis of the buttock, hemorrhoid." 3. " property of medicine is examined ": " detoxifies, clearing stomach, pathogenic fire reducing.Sore is controlled in " 4. " Guizhou side's medicine among the people collection ": " external." 5. " Traditional Chinese Medicine in Sichuan will ": " bag venom." 6. " Chinese herbal medicine is commonly used in Shanghai ": " heart tonifying diuresis.Control heart disease edema out of breath."
Radix Camelliae sinensis: bitter; Cool.GUIXIN; Kidney channel.Function cures mainly: heart tonifying diuresis; Promoting blood flow to regulate menstruation; Heat-clearing and toxic substances removing.Main heart disease; Edema; Hepatitis; Dysmenorrhea; Sore swollen toxin; Aphtha; Soup fire is burnt; Herpes zoster; Psoriasis.
Cortex Magnoliae Officinalis: Cortex Magnoliae Officinalis and volatile oil bitter in the mouth thereof can stimulate the sense of taste, reflexively causes saliva, gastric secretion, gastrointestinal peristalsis to accelerate, and has stomach invigorating digestion-aid effect; The checking of resisting pathogenic microbes acting body exterior-excess is bright, and Cortex Magnoliae Officinalis decoct all has antibacterial action to gram negative bacillis such as the gram positive bacterias such as staphylococcus, Hemolytic streptococcus, streptococcus pneumoniae, bordetella pertussis and anthrax bacillus, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, vibrio cholera, escherichia coli, Bacillus proteus, bacillus subtilis; Decoct has inhibitory action to Bufo siccus isolated heart. magnocurarine drug administration by injection, having obvious hypotensive effect lower than during muscle relaxant amount, this effect can not by antihistaminic institute antagonism, the blood pressure lowering of Bolos intravenous administration is held time and is about 10 ~ 15 minutes, and the blood pressure lowering of intramuscular administration is held time, and can reach more than 1 hour.The tincture hydrotrope of Flos Magnoliae Officinalis all has hypotensive effect to anesthetized cat, the quiet note of rabbit or intramuscular injection, and can make increased heart rate.
Rhizoma Dioscoreae: sweet in the mouth, property are flat, enter lung, spleen, kidney channel; Not dry oiliness, have strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, long will are calmed the nerves, effect of life lengthening; Cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity be weak, the red disease such as swollen, fat of frequent micturition of quenching one's thirst, seminal emission premature ejaculation, leukorrhagia nebulousurine, skin.Compendium of Material Medica summary five large functions " kidney tonifying gas, strengthening the spleen and stomach, stopping leak dysentery, reduce phlegm saliva, profit skin ".Rhizoma Dioscoreae cook congee or with crystal sugar simmer ripe after take, poor to health, colitis, deficiency of the kidney chronic diseases are all effective in cure.Strengthen the spleen and stomach: treat weakness of the spleen and stomach, have loose bowels, body is tired, lack of appetite, sweating due to debility.Lung benefiting nourishing kidney: this product is cold not dry, and sweet in the mouth matter is moistened, that can treat that lung suffers from a deficiency of the kidney and damage quenches one's thirst, passes out semen, is with inferior disease.Be described as angle's medicine.
Red shank: pungent, temperature.Function cures mainly: diaphoresis dehumidifies, and help digestion antidiarrheal.
Herba Herminii: sweet in the mouth, warm in nature.Function cures mainly: heart tonifying the kidney invigorating, promoting the production of body fluid to quench thirst, spleen reinforcing stomach invigorating, regulating menstruation and activating blood.Control neurasthenia, insomnia is dizzy, irritated thirsty, anorexia.
Fructus Crataegi: sour in the mouth, sweet, slightly warm in nature, enters spleen, stomach, Liver Channel, for promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, be mainly used to treat accumulation of food in the stomach and intes tine due to indigestion, have loose bowels, dysentery, Fructus Crataegi be the staple for the treatment of dyspepsia, and Fructus Crataegi can increase the secretion of peptic digestion enzyme, facilitating digestion; To dysentery bacterium, bacillus pyocyaneus, staphylococcus aureus etc., there is obvious inhibitory action.
Ganoderma: property is sweet, flat.GUIXIN, lung, liver, kidney channel.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.Animal pharmacology shows experiment: Ganoderma has inhibitory action to nervous system, and blood circulation has blood pressure lowering and strengthens the effect of cardiac contractile force, has phlegm-dispelling functions to respiratory system, in addition, also has hepatoprotective, improves immunologic function, antibacterially waits effect.
Fructus Jujubae: there is immunosuppressive action, the ethanol extract of Fructus Jujubae with every day 100mg to rat oral gavage, display Fructus Jujubae has same immunosuppressant with azathioprine; The generation of antibody can be suppressed to atopic diseases.Fructus Jujubae ethanol extract may have inhibitory action to rat reactive antibody, and other effects of inhibitory action are not produced to non-reacted antibody: the two glucoside A of the flavone in Fructus Jujubae, pharmacological evaluation proves have calmness, hypnosis and hypotensive effect, and Fructus Jujubae has the effect increasing cAMP in leukocyte.Fructus Jujubae decoct can reduce the damage of CCl4 to Rabbit Liver.The swimming time of mice can be extended.Nearest report Fructus Jujubae has the proliferation function of anticancer.
Semen Ziziphi Spinosae: sweet, sour is flat.Return liver, gallbladder, heart channel.Function cures mainly: tonifying liver, mind calming, and arresting sweating promotes the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.
Fructus Fici Heteromo: sweet, sour, temperature.Function cures mainly: stimulating milk secretion is enriched blood.Cure mainly disease such as insufficiency of the spleen stomach weak grade.
Semen Abutili: sweet; Cold.Return large intestine; Small intestinal; Liver; Lung; Stomach; Urinary bladder channel.Function cures mainly: relieving stranguria by diuresis; Laxation relieving constipation; Stimulating milk secretion.Main gonorrhea; Edema; Constipation; Breast antiperspirant is not all right.
Fructus Lycii: nourishing the liver and kidney, replenishing vital essence to improve eyesight; For chronic consumptive disease damage of essence, soreness of waist and knee joint; Vertigo and tinnitus, interior-heat Xiao are thirsty, blood deficiency and yellow complexion, and blurred vision is failed to understand.Cure mainly caused by liver and kidney deficiency; Have a dizzy spell; Visual deterioration; Soreness of the waist and knees; Seminal emission is quenched one's thirst; Cough due to consumptive disease.The hepatic and renal YIN deficiency, blood deficiency, soreness of the waist and knees, chronic ocular disease, have a dizzy spell, the condition subject such as asthenia is thin and weak, diabetes, hypertension, hyperlipemia, arteriosclerosis, chronic hepatitis, fatty liver and cancer patient's radiotherapy, suitable edible after chemotherapy.
Semen Arecae: bitter in the mouth; Pungent; Warm in nature.Return stomach; Large intestine channel.Effect, anthelmintic; Removing food stagnancy; The therapeutic method to keep the adverse QI flowing downwards; Row water; Preventing the attack (or recurrence) of malaria.Malnutrition due to parasitic infestation; Dyspepsia; Abdominal distention; Heavy after dysentery; Foot gas; Edema; Malaria.Resisting pathogenic microbes effect.Semen Arecae infusion (1:1) in vitro to trichophyton, permitted the dermatophytes such as blue achorion and had inhibitory action in various degree.Decoct and some strain of water logging agent infected by influenza A type have certain inhibitory action, and antiviral effect may be relevant with wherein contained tannin.
Herba Menthae: pungent is cool.Return lung, Liver Channel.Function cures mainly: dispelling wind-heat.Refresh oneself, rash.For anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, breast the side of body feeling of distension and oppression.
Borneolum Syntheticum: arduous, cool; Enter the heart, lung meridian.Tang Materia Medica: " main trusted subordinate's pathogen, rheumatism is gathered, deaf.Improving eyesight, goes conjunctival congestion skin nebula.External oculopathy eye in " " Haiyao Bencao, Oversea Materia Medica ": " is main, three worms, control five hemorrhoid, improving eyesight, relieving palpitation, secret essence." logical all keys, loose stagnated fire, removing nebula improving eyesight, reducing swelling and alleviating pain.Control apoplexy locked mouth, calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, order is nebula film also, enterobiasis.Borneolum Syntheticum topical application has comparatively microstimulation to sensory nerve, has certain pain relieving and the antisepsis of gentleness.In beauty treatment side with make heat-clearing and fire-dispersing, ward off the turbid product of dirtyization, for because of heat in blood, interior-heat pents up the treatment of the diseases such as caused halitosis, bromhidrosis, skin infection furuncle.
Herba Pogostemonis: its gas fragrance, benefaction gastric qi, in adjusting with this, stopping vomiting tells cholera, and with this fast gas, dirt eliminating jailbird is vexed.Herba Pogostemonis can and close the five internal organs, if incoordination between the spleen and stomach, with rib stomach and enter diet, have the merit of appetizing of being amusing.Pungent energy tonneau nine orifices, if haze miasma epidemic disease is with it, does not make to invade in exopathogen, has the power of presiding over healthy energy.All all gas medicines, solely this body is gently warm in nature, can defend gas greatly, specially supports lung stomach.But leaf belongs to sun, is the thing of generation, its property is sharp and fragrant loose, should not take more.There is Antitussive and Expectorant Effect, antiinflammatory, antibacterial action.Low dose of geraniol can suppress the spontaneous activity of rat.Oral Administration in Rats geraniol can suppress gastrointestinal motility, and oral in a small amount have mild diuretic effect." book on Chinese herbal medicine justice ": Fructus Tsaoko, pungent warm-dryness syndrome is strong, kind eliminating cold-damp and warm-dryness syndrome Middle Palace, therefore is taste cold-damp principal agent.By haze miasma all mist to expose private part wet heresy, the gas of the clear sun of wound, therefore it is fragrant to ward off the multiplex warm-dryness syndrome of miasma, Yi Shengyin suddenly turbid damp accumulate haunt and plague.Fructus Tsaoko control subtertian malaria, meaning be also still.Right every malaria, many damp-phlegm are hoodwinked as suffering from, therefore alternate attack of chill and fever, lingering, controlling using pungent drugs for dispersion and bitter drugs for purgation to be first.Fructus Tsaoko is kind washs damp-phlegm, and the spleen sun that shakes, more with the Rhizoma Anemarrhenae auxiliary it, consider its component, at any time the profit and loss, treating malaria quite has wonderful justice, admittedly need not aim at the legislation of haze miasma.The only stupid so-called excess pathogen of stone not Sheng person, when at prohibited ear.
Pyrethrum: bitter, cool.Function cures mainly: parasite killing.Scabies is controlled in external.Can mosquito killing, fly, louse; Kill maggot; Anophelifuge.
 
Embodiment 1 Chinese medicine additive 1-powder
Embodiments provide a kind of Chinese medicine additive being used for the treatment of Bovine Ephemeral Fever, in Chinese medicine compositions, the parts by weight of each raw medicinal material are: Rhizoma Coptidis 8 weight portion, Herba Houttuyniae 17 weight portion, Herba Scutellariae Barbatae 14 weight portion, Flos Trollii 15 weight portion, Radix et Rhizoma Dysosmatis 7 weight portion, Spora Lygodii 7 weight portion, Flos Chrysanthemi 19 weight portion, Caulis et Folium fici Tikouae 11 weight portion, Radix Gentianae Macrophyllae 9 weight portion, Rhizoma Smilacis Chinensis 8 weight portion, Exocarpium Citri Rubrum 12 weight portion, the Radix Astragali 7 weight portion, Exocarpium Benincasae 15 weight portion, Herba Apocyni veneti 5 weight portion, Rohdea japonica Roth 5 weight portion, Radix Camelliae sinensis 14 weight portion, Cortex Magnoliae Officinalis 18 weight portion, Rhizoma Dioscoreae 19 weight portion, red shank 11 weight portion, Herba Herminii 11 weight portion and Fructus Crataegi 9 weight portion.
Its preparation method is:
The first step: described raw medicinal material is mixed in proportion, drop into pulverizer to carry out pulverizing or directly shredding, load and decoct in container, add 2 times of water gagings and make its submergence medical material, soak after 15 minutes, be heated to boiling after 60 minutes, be separated fried liquid, medicinal residues again add water and carry out decoction 2 times, the fried liquid that separated and collected is each, again after filtering, get filtrate and abandon filtering residue;
Second step: after liquid cooling but to be filtered, adding relative to the determining alcohol of concentrated rear liquid weight 2 times is 85% ethanol, abundant mix homogeneously, placement is spent the night, and makes it precipitate, and obtains filtrate after getting its supernatant liquid filtering next day, precipitate determining alcohol be 55% ethanol clean, collect washing liquid and also merge with filtrate, after decompression withdrawal ethanol, dislocation lets cool place, leave standstill 1 hour, make precipitation complete, filter, filtrate low-temperature evaporation, obtains paste;
3rd step: paste is put into spray dryer dry, ensure that inlet temperature is at 180 DEG C, leaving air temp 80 DEG C, is ground into 350 orders subsequently, obtains Chinese powder medicine.
 
Embodiment 2 Chinese medicine additive 2-injection
Embodiments provide a kind of Chinese medicine additive being used for the treatment of Bovine Ephemeral Fever, in Chinese medicine compositions, the parts by weight of each raw medicinal material are: Rhizoma Coptidis 8 weight portion, Herba Houttuyniae 17 weight portion, Herba Scutellariae Barbatae 14 weight portion, Flos Trollii 15 weight portion, Radix et Rhizoma Dysosmatis 7 weight portion, Spora Lygodii 7 weight portion, Flos Chrysanthemi 19 weight portion, Caulis et Folium fici Tikouae 11 weight portion, Radix Gentianae Macrophyllae 9 weight portion, Rhizoma Smilacis Chinensis 8 weight portion, Exocarpium Citri Rubrum 12 weight portion, the Radix Astragali 7 weight portion, Exocarpium Benincasae 15 weight portion, Herba Apocyni veneti 5 weight portion, Rohdea japonica Roth 5 weight portion, Radix Camelliae sinensis 14 weight portion, Cortex Magnoliae Officinalis 18 weight portion, Rhizoma Dioscoreae 19 weight portion, red shank 11 weight portion, Herba Herminii 11 weight portion, Fructus Crataegi 9 weight portion, Ganoderma 15 weight portion, Fructus Jujubae 11 weight portion, Semen Ziziphi Spinosae 11 weight portion, Fructus Fici Heteromo 9 weight portion, Semen Abutili 11 weight portion and Fructus Lycii 8 weight portion.
Its preparation method is:
The first step, takes all raw medicinal materials according to ratio of weight and number, co-grinding, decoct with water 3 times, each decocting time is 2 hours, and the water quality added is 3 times of first step mixture quality, merge decoction liquor, filter, filtrate is concentrated into syrupy shape, adds the ethanol that determining alcohol is more than 95%, the ethanol content added is 2 times of the mixture quality of the first step, leave standstill after 18 hours, centrifugal filtration, filtrate with 45% NaOH to be adjusted to filtrate pH be 7;
Second step, by the filtrate that the first step obtains, adds 0.8% active carbon and boils 20 minutes, filters, decarburization, injects with water, makes the crude drug concentration of injection be 3g/ml, and fill sterilizing 1.5 hours in 500ml saline bottle, after freezing a couple of days, filters.
 
Embodiment 3 feedstuff
Embodiments provide a kind of feedstuff being used for the treatment of Bovine Ephemeral Fever, wherein the parts by weight of each raw material are: Semen Maydis 45 weight portion, bean cake 18 weight portion, corn straw 14 weight portion, Pericarppium arachidis hypogaeae 16 weight portion, Semen arachidis hypogaeae dregs 17 weight portion, corn germ cake 8 weight portion, Semen Vitis viniferae 6 weight portion, Retinervus Luffae Fructus 6 weight portion, bagasse 5 weight portion, cabbage leaves 5 weight portion of drying, spray-dried plasma protein 3 weight portion, glucose 3 weight portion, mixed active bacterium liquid 3 weight portion, Sal 2 weight portion, soybean oil 2 weight portion, microelement pre-mix material 0.8 weight portion and Chinese medicine additive 5 weight portion.
Wherein, described mixed active bacterium liquid is lactobacillus and bacillus bifidus; Described microelement pre-mix material is copper, ferrum, manganese, zinc, iodine, selenium.
In described Chinese medicine additive, the parts by weight of each raw medicinal material are: Rhizoma Coptidis 8 weight portion, Herba Houttuyniae 17 weight portion, Herba Scutellariae Barbatae 14 weight portion, Flos Trollii 15 weight portion, Radix et Rhizoma Dysosmatis 7 weight portion, Spora Lygodii 7 weight portion, Flos Chrysanthemi 19 weight portion, Caulis et Folium fici Tikouae 11 weight portion, Radix Gentianae Macrophyllae 9 weight portion, Rhizoma Smilacis Chinensis 8 weight portion, Exocarpium Citri Rubrum 12 weight portion, the Radix Astragali 7 weight portion, Exocarpium Benincasae 15 weight portion, Herba Apocyni veneti 5 weight portion, Rohdea japonica Roth 5 weight portion, Radix Camelliae sinensis 14 weight portion, Cortex Magnoliae Officinalis 18 weight portion, Rhizoma Dioscoreae 19 weight portion, red shank 11 weight portion, Herba Herminii 11 weight portion, Fructus Crataegi 9 weight portion, Ganoderma 15 weight portion, Fructus Jujubae 11 weight portion, Semen Ziziphi Spinosae 11 weight portion, Fructus Fici Heteromo 9 weight portion, Semen Abutili 11 weight portion and Fructus Lycii 8 weight portion.
The preparation method of described Chinese medicine additive is:
The first step: described raw medicinal material is mixed in proportion, drop into pulverizer to carry out pulverizing or directly shredding, load and decoct in container, add 2 times of water gagings and make its submergence medical material, soak after 20 minutes, be heated to boiling after 40-70 minute, be separated fried liquid, medicinal residues again add water and carry out decoction 2-3 time, the fried liquid that separated and collected is each, again after filtering, get filtrate and abandon filtering residue;
Second step: after liquid cooling but to be filtered, adding relative to the determining alcohol of concentrated rear liquid weight 2 times is 85% ethanol, abundant mix homogeneously, placement is spent the night, and makes it precipitate, and obtains filtrate after getting its supernatant liquid filtering next day, precipitate determining alcohol be 55% ethanol clean, collect washing liquid and also merge with filtrate, after decompression withdrawal ethanol, dislocation lets cool place, leave standstill 0.5 hour, make precipitation complete, filter, filtrate low-temperature evaporation, obtains paste;
3rd step: paste is put into spray dryer dry, ensure that inlet temperature is at 200 DEG C, leaving air temp 80 DEG C, is ground into 350 orders subsequently, obtains Chinese powder medicine.
The preparation method of described feedstuff is:
(1) by weight the cabbage leaves mixing of Semen Maydis in above-mentioned raw materials, bean cake, corn straw, Pericarppium arachidis hypogaeae, Semen arachidis hypogaeae dregs, corn germ cake, Semen Vitis viniferae, Retinervus Luffae Fructus, bagasse and oven dry is ground, add the mixed active bacterium liquid that water dilutes 3 times, sealing and fermenting after stirring, control temperature is at 30 DEG C, and ferment the compound that must ferment for 5 hours;
(2) mixed with other raw materials by above-mentioned fermentation compound, temperature is dried under 35 DEG C of conditions, pulverizes 60 mesh sieves.
 
Embodiment 4 Traditional Chinese medicinal spray
Embodiments provide a kind of Traditional Chinese medicinal spray being used for the treatment of Bovine Ephemeral Fever, wherein the parts by weight of each raw medicinal material are: Rhizoma Coptidis 27 weight portion, Herba Scutellariae Barbatae 21 weight portion, Flos Chrysanthemi 9 weight portion, Caulis et Folium fici Tikouae 8 weight portion, Exocarpium Citri Rubrum 11 weight portion, Ganoderma 9 weight portion, Semen Arecae 5 weight portion, Herba Menthae 4 weight portion, Borneolum Syntheticum 2 weight portion, Herba Pogostemonis 2 weight portion and Pyrethrum 2 weight portion.
The preparation method of described Traditional Chinese medicinal spray is:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 4cm, soak 5 hours;
Step 2: be placed in by purple casserole on fire, after intense fire boils, uses slow fire instead and decocts 40 minutes slowly, filters, obtains filtrate a, for subsequent use;
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2.5cm, soaks 4 hours;
Step 4: be placed in by purple casserole on fire, after intense fire boils, uses slow fire instead and decocts 30 minutes slowly, filters, obtains filtrate b, mixed by filtrate a and filtrate b.
During use, Traditional Chinese medicinal spray clear water is diluted 7 times can be sprayed, and not only has the effect of cooling, also has the effect for the treatment of Bovine Ephemeral Fever and control infection.
 
Toxicity test
(1) apply NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; Powder prepared by embodiments of the invention 1 is dissolved in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 32.9 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>32.9 crude drug/kg of the present invention, every day, maximum dosage-feeding was 65.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 4.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.073g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 20g) oral administration gavage Chinese medicine of the present invention is 901 times of quantity.Therefore Chinese medicine composition acute toxicity of the present invention is low, clinical drug safety.
(2) powder of the embodiment of the present invention 1 is pressed 7.81,18.34 and 40.11g crude drug/kg continuous use 12 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 12 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
(3) (1) animal is selected
Cleaning grade kunming mice 40, male and female half and half, body weight 18 ~ 22 g; Laboratory observation 1 week, before each administration, fasting 4 h, can't help water.
(2) test grouping
By above cleaning grade kunming mice laboratory observation 1 week, the cleaning grade kunming mice of clinical observation result health is divided into two groups at random, often organizes 20 (male and female half and half).Wherein one group is set as experimental group, and another group is set as matched group.
(3) medication and dosage
Mouse tail vein injection, experimental group is with successive administration in maximum (former) concentration of the embodiment of the present invention 2 and maximum volume 24 h 3 times, give 0.6 ml/20g(Mouse Weight) medicine, i.e. the injection 1.8g(crude drug amount of mouse tail vein injection embodiment 2 in 24 h)/20g(Mouse Weight); Matched group is to the injection normal saline of same volume.
(4) observational technique and index
Weigh the weight of animals before administration and observe feed intake and drinking-water situation; After administration, every day weighs the weight of animals, feed intake and undue toxicity's symptom at same time, Continuous Observation 14 d.Observation index is as follows: 1. take action, as unease, many dynamic, sounding; 2. nervous system reaction, as lifted tail, chatter, spasm, movement disorder, attitude extremely; 3. autonomic nervous system reaction, as exophthalmos, sialorrhea, shed tears, urinate, drop, perpendicular hair, dyschromasia, adnormal respiration; 4. drinking-water and appetite change, defecation and color thereof, nose, eye, oral cavity whether with or without abnormal secretion thing, body weight change; 5. death condition.
(5) experimental result
By the observation of 14 d, two groups all do not have undue toxicity to react appearance, do not occur yet animal dead phenomenon.Therefore, the injection of the embodiment of the present invention 2 has no side effect.
(4) according to 6.3 joints in Ministry of Public Health " cosmetics health specification " (2002) Part II " skin irritation/corrosion test ", male 4 of Japan large ear rabbit, body weight 2kg ~ 3kg, according to the method for above-mentioned " acute dermal toxicity test ", the Traditional Chinese medicinal spray of embodiment 4 is prepared into paste coating, then getting 0.5g directly to spread upon on the left of animal on skin (opposite side in contrast), adopt blocking test, 4 hours application time, tested material is remained with warm water washing after off-test, 1h after removing tested material, 24h, 48h and 72h observes the dermoreaction of the tested district of animal and check plot respectively, top average is " 0 ", judge that Traditional Chinese medicinal spray is to animal skin nonirritant.
 
Contrast test
The large-scale cultivation base of Shandong Province milch cow cultivates the milk cow in lactation period 624 of about three years old altogether, find that milch cow generally occurs that lactation amount sharply declines the phenomenon even stopped in mid-July, 2013, many milch cows are also had to occur that body temperature is up to 42 DEG C, appetite declines even absolutely useless, tripe is swollen utters a sound or a word, there is death, lung high level expansion is found through dissecting, interstitial is broadening, inside there is bubble, pressing lung is crepitation, tunicle swells, lung parenchyma tissue forms space, trachea inner product has volume spumescence mucus, mucosa hemorrhage, lymph nodes of body as a whole swelling, fourth stomach and caecum mucosa have petechia, pericardial effusion.Be diagnosed as Bovine Ephemeral Fever, immediately ill cattle is isolated, select ill milch cow 500, be divided into five groups at random, be respectively embodiment group 1-4 and matched group, each group of milch cow is compared in age, body weight, parity, lactation stage and ill front milk yield etc., and no significant difference (P > 0.05), has comparability.
Therapeutic Method:
Embodiment group 1: use the powder of the embodiment of the present invention 1 to treat, powder is mixed in conventional feed according to 5:100 ratio of weight and number, feeds according to normal feed mode, or gavage after directly powder being dissolved, every day twice, each powder 0.5mg/kg;
Embodiment group 2: use the injection of the embodiment of the present invention 2 to treat, once a day, 0.8mg/kg, feeds conventional feed according to normal feed mode;
Embodiment group 3: the ill milch cow of forage feed using the embodiment of the present invention 3, feeds according to normal feed mode;
Embodiment group 4: the same with the preparation method of embodiment group 1, and use the spray of the embodiment of the present invention 4 to cow sprinkling, once a day;
Matched group: select 30% dipyrone 3-4g, intramuscular injection, fit applications injection kanamycin, 3.5 mg/kg, deep intramuscular injection, once a day, is used in conjunction 4
Wherein, embodiment group 1-3 and matched group are conventionally lowered the temperature to cow sprinkling clear water according to situations such as temperature; Above-mentioned therapeutic modality treatment totally 7 days, the recovery different according to milch cow and recovery from illness situation are discontinued medication; Symptom all disappears, and it is recovery from illness that milk yield all recovers normal, and symptom disappears substantially, and milk yield reverts to effectively substantially, and symptom does not take a turn for the better even dead for invalid, and therapeutic outcome as shown in Table 1 and Table 2.Before ill, the normal milk yield of milch cow is regularly followed the tracks of in cultivation base, calculate the normal daily yielding of ill front milch cow, the treatment time limit is on July 27 ,-2013 years on the 21st July in 2013, also follow the tracks of at treatments period, calculate the daily yielding for the treatment of after 7 days recovery situation and treatment after 15 days in daily yielding, result is as shown in table 3.
Therapeutic outcome:
Table 1 is group therapeutic effect contrast gauge outfit respectively
Group Sum Recovery from illness Effectively Invalid Dead
Embodiment group 1 100 92 7 1 1
Embodiment group 2 100 93 7 0 0
Embodiment group 3 100 94 6 0 0
Embodiment group 4 100 93 7 0 0
Matched group 100 76 21 3 2
Table 2 is group recovery from illness milk ox head number and healing time synopsis respectively
Group Sum 1-3 days 4-6 days 7th day
Embodiment group 1 92 34 52 6
Embodiment group 2 93 37 53 3
Embodiment group 3 94 41 52 1
Embodiment group 4 93 36 55 2
Matched group 76 27 38 11
From above table data, the Chinese medicine composition that the embodiment of the present invention 1 and embodiment 2 provide have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect, the feedstuff of embodiment 3 has outstanding advantage at treatment Bovine Ephemeral Fever, and the spray of embodiment 4 can significantly improve therapeutic effect and shorten healing time.
Table 3 is group milch cow daily yielding synopsis respectively
Group Normal daily yielding Onset to 2013 daily yielding in 20, on July Stop treatment latter 15 days daily yieldings
Embodiment group 1 31.3kg 17.8kg 31.5kg
Embodiment group 2 31.5kg 18.1kg 32.0kg
Embodiment group 3 31.4kg 17.9kg 32.3kg
Embodiment group 4 31.3kg 17.6kg 31.7kg
Matched group 31.5kg 17.7kg 27.4kg
From the data of table 3, compared with matched group, the feedstuff of Chinese medicine composition of the present invention especially embodiment 3 can be good at the milk yield recovering ill milch cow; And observe the quality of milk, the quality that obvious embodiment is respectively organized obviously is better than matched group from the aspect such as purity, concentration, and wherein the quality of embodiment group 3 milk is the highest.
 
Model case
At the beginning of 2012 8 months, milk cattle cultivating self-employed entrepreneurs cultivates 10 cow heads, and 10 cow heads all occur that appetite declines, a phenomenon of uttering a sound or a word that tripe is swollen, wherein be in lactational 8 cow head milk yield obviously to decline, and wherein two Contents in Cows temperature rise to 40 DEG C, be diagnosed as Bovine Ephemeral Fever, conventional feed replaced by the feedstuff of the embodiment of the present invention of feeding immediately 3, and use every day the Traditional Chinese medicinal spray of the embodiment of the present invention 4 to carry out spraying cooling, treat 8 cow head recoveries from illness in 2 days, continual cure is all fully recovered for 1 day, cure rate 100%.
 
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (7)

1. be used for the treatment of the pharmaceutical composition of milk Bovine Ephemeral Fever, it is characterized in that, described pharmaceutical composition comprises following raw medicinal material: Rhizoma Coptidis, Herba Houttuyniae, Herba Scutellariae Barbatae, Flos Trollii, Radix et Rhizoma Dysosmatis, Spora Lygodii, Flos Chrysanthemi, Caulis et Folium fici Tikouae, Radix Gentianae Macrophyllae, Rhizoma Smilacis Chinensis, Exocarpium Citri Rubrum, the Radix Astragali, Exocarpium Benincasae, Herba Apocyni veneti, Rohdea japonica Roth, Radix Camelliae sinensis, Cortex Magnoliae Officinalis, Rhizoma Dioscoreae, red shank, Herba Herminii and Fructus Crataegi.
2. the pharmaceutical composition being used for the treatment of milk Bovine Ephemeral Fever according to claim 1, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Rhizoma Coptidis 5-13 weight portion, Herba Houttuyniae 10-25 weight portion, Herba Scutellariae Barbatae 11-17 weight portion, Flos Trollii 10-20 weight portion, Radix et Rhizoma Dysosmatis 5-13 weight portion, Spora Lygodii 5-11 weight portion, Flos Chrysanthemi 13-22 weight portion, Caulis et Folium fici Tikouae 8-15 weight portion, Radix Gentianae Macrophyllae 5-15 weight portion, Rhizoma Smilacis Chinensis 5-10 weight portion, Exocarpium Citri Rubrum 8-16 weight portion, Radix Astragali 5-9 weight portion, Exocarpium Benincasae 11-18 weight portion, Herba Apocyni veneti 3-7 weight portion, Rohdea japonica Roth 3-7 weight portion, Radix Camelliae sinensis 10-17 weight portion, Cortex Magnoliae Officinalis 15-20 weight portion, Rhizoma Dioscoreae 15-22 weight portion, red shank 5-15 weight portion, Herba Herminii 7-15 weight portion and Fructus Crataegi 5-13 weight portion.
3. the pharmaceutical composition being used for the treatment of milk Bovine Ephemeral Fever according to claim 1 and 2, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Rhizoma Coptidis 8 weight portion, Herba Houttuyniae 17 weight portion, Herba Scutellariae Barbatae 14 weight portion, Flos Trollii 15 weight portion, Radix et Rhizoma Dysosmatis 7 weight portion, Spora Lygodii 7 weight portion, Flos Chrysanthemi 19 weight portion, Caulis et Folium fici Tikouae 11 weight portion, Radix Gentianae Macrophyllae 9 weight portion, Rhizoma Smilacis Chinensis 8 weight portion, Exocarpium Citri Rubrum 12 weight portion, the Radix Astragali 7 weight portion, Exocarpium Benincasae 15 weight portion, Herba Apocyni veneti 5 weight portion, Rohdea japonica Roth 5 weight portion, Radix Camelliae sinensis 14 weight portion, Cortex Magnoliae Officinalis 18 weight portion, Rhizoma Dioscoreae 19 weight portion, red shank 11 weight portion, Herba Herminii 11 weight portion and Fructus Crataegi 9 weight portion.
4. the pharmaceutical composition being used for the treatment of milk Bovine Ephemeral Fever according to any one of claim 1-3, is characterized in that, described pharmaceutical composition also comprises: Ganoderma, Fructus Jujubae, Semen Ziziphi Spinosae, Fructus Fici Heteromo, Semen Abutili and Fructus Lycii, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Rhizoma Coptidis 5-13 weight portion, Herba Houttuyniae 10-25 weight portion, Herba Scutellariae Barbatae 11-17 weight portion, Flos Trollii 10-20 weight portion, Radix et Rhizoma Dysosmatis 5-13 weight portion, Spora Lygodii 5-11 weight portion, Flos Chrysanthemi 13-22 weight portion, Caulis et Folium fici Tikouae 8-15 weight portion, Radix Gentianae Macrophyllae 5-15 weight portion, Rhizoma Smilacis Chinensis 5-10 weight portion, Exocarpium Citri Rubrum 8-16 weight portion, Radix Astragali 5-9 weight portion, Exocarpium Benincasae 11-18 weight portion, Herba Apocyni veneti 3-7 weight portion, Rohdea japonica Roth 3-7 weight portion, Radix Camelliae sinensis 10-17 weight portion, Cortex Magnoliae Officinalis 15-20 weight portion, Rhizoma Dioscoreae 15-22 weight portion, red shank 5-15 weight portion, Herba Herminii 7-15 weight portion, Fructus Crataegi 5-13 weight portion, Ganoderma 10-20 weight portion, Fructus Jujubae 8-12 weight portion, Semen Ziziphi Spinosae 7-15 weight portion, Fructus Fici Heteromo 5-12 weight portion, Semen Abutili 8-15 weight portion and Fructus Lycii 5-12 weight portion.
5. the pharmaceutical composition being used for the treatment of milk Bovine Ephemeral Fever according to any one of claim 1-4, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Rhizoma Coptidis 8 weight portion, Herba Houttuyniae 17 weight portion, Herba Scutellariae Barbatae 14 weight portion, Flos Trollii 15 weight portion, Radix et Rhizoma Dysosmatis 7 weight portion, Spora Lygodii 7 weight portion, Flos Chrysanthemi 19 weight portion, Caulis et Folium fici Tikouae 11 weight portion, Radix Gentianae Macrophyllae 9 weight portion, Rhizoma Smilacis Chinensis 8 weight portion, Exocarpium Citri Rubrum 12 weight portion, the Radix Astragali 7 weight portion, Exocarpium Benincasae 15 weight portion, Herba Apocyni veneti 5 weight portion, Rohdea japonica Roth 5 weight portion, Radix Camelliae sinensis 14 weight portion, Cortex Magnoliae Officinalis 18 weight portion, Rhizoma Dioscoreae 19 weight portion, red shank 11 weight portion, Herba Herminii 11 weight portion, Fructus Crataegi 9 weight portion, Ganoderma 15 weight portion, Fructus Jujubae 11 weight portion, Semen Ziziphi Spinosae 11 weight portion, Fructus Fici Heteromo 9 weight portion, Semen Abutili 11 weight portion and Fructus Lycii 8 weight portion.
6. the pharmaceutical composition being used for the treatment of milk Bovine Ephemeral Fever according to any one of claim 1-5, is characterized in that, the dosage form of described pharmaceutical composition is powder, and its preparation method is:
The first step: described raw medicinal material is mixed in proportion, drop into pulverizer to carry out pulverizing or directly shredding, load and decoct in container, add 2-3 times of water gaging and make its submergence medical material, soak after 10-25 minute, be heated to boiling after 40-70 minute, be separated fried liquid, medicinal residues again add water and carry out decoction 2-3 time, the fried liquid that separated and collected is each, again after filtering, get filtrate and abandon filtering residue;
Second step: after liquid cooling but to be filtered, adding relative to concentrated rear liquid weight 1-2 determining alcohol is doubly 80-90% ethanol, abundant mix homogeneously, placement is spent the night, and makes it precipitate, and obtains filtrate after getting its supernatant liquid filtering next day, precipitate determining alcohol is that the ethanol of 50-60% is cleaned, and collects washing liquid and merges with filtrate, after ethanol is regained in decompression, dislocation lets cool place, leave standstill 0.5-1 hour, make precipitation complete, filter, filtrate low-temperature evaporation, obtains paste;
3rd step: paste is put into spray dryer dry, ensure that inlet temperature is at 180 DEG C-200 DEG C, leaving air temp 70 DEG C-90 DEG C, is ground into 300 order-400 orders subsequently, obtains Chinese powder medicine.
7. the pharmaceutical composition being used for the treatment of milk Bovine Ephemeral Fever according to any one of claim 1-5, is characterized in that, the dosage form of described pharmaceutical composition is injection, and its preparation method is:
The first step, takes all raw medicinal materials according to ratio of weight and number, co-grinding, decoct with water 2 ~ 4 times, each decocting time is 2 ~ 3 hours, and the water quality added is 2 ~ 4 times of first step mixture quality, merge decoction liquor, filter, filtrate is concentrated into syrupy shape, adds the ethanol that determining alcohol is more than 95%, the ethanol content added is 1 ~ 2 times of the mixture quality of the first step, leave standstill after 12 hours ~ 24 hours, centrifugal filtration, filtrate is adjusted to filtrate pH7 ~ 8 with the NaOH of 40% ~ 50%;
Second step, by the filtrate that the first step obtains, adds 0.5% ~ 1% active carbon and boils 18 ~ 22 minutes, filters, decarburization, injects with water, makes the crude drug concentration of injection be 2 ~ 4g/ml, fill sterilizing 1.5 hours ~ 2 hours in 500ml saline bottle, after freezing a couple of days, filters.
CN201410579083.4A 2014-10-24 2014-10-24 Pharmaceutical composition for treating ephemeral fever of dairy cow and preparation method thereof Pending CN104306817A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105106724A (en) * 2015-09-25 2015-12-02 山东新希望六和集团有限公司 Medicine for treating bovine ephemeral fever and preparation method thereof
CN105878832A (en) * 2016-04-19 2016-08-24 烟台民望机电技术有限公司 Traditional Chinese medicine composition for preventing and controlling sheep bluetongue and preparation method of traditional Chinese medicine composition

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
李如焱: "自拟银翘解毒汤治牛流行热", 《中兽医学杂志》 *
马玉芳等: "中草药防治牛羊传染病概况", 《中兽医医药杂志》 *
马维滨: "天水市北道区牛流行热的诊疗", 《甘肃畜牧兽医》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105106724A (en) * 2015-09-25 2015-12-02 山东新希望六和集团有限公司 Medicine for treating bovine ephemeral fever and preparation method thereof
CN105878832A (en) * 2016-04-19 2016-08-24 烟台民望机电技术有限公司 Traditional Chinese medicine composition for preventing and controlling sheep bluetongue and preparation method of traditional Chinese medicine composition

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Application publication date: 20150128