CN103055157B - Compound dendrobium huoshanense, cistanche and ganoderma granules and production process thereof - Google Patents
Compound dendrobium huoshanense, cistanche and ganoderma granules and production process thereof Download PDFInfo
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Abstract
The present invention discloses compound dendrobium huoshanense, cistanche and ganoderma granules and a production process thereof; and the formula thereof comprises the following ingredients, by weight: 10-15% of dendrobium huoshanense, 20-25% of mulberry, 5-10% of cistanche, 5-10% of ganoderma, and 40-60% of functional oligosaccharide. According to the invention, effective extract and use of medicinal ingredients in dendrobium huoshanense, mulberry, cistanche, and ganoderma are realized; dissolution rates of active ingredients (water-soluble components, and alcohol-soluble components) of dendrobium huoshanense, mulberry, cistanche, and ganoderma are improved; and the granules are instant to dissolve, convenient to take and good in effect.
Description
Technical field
The present invention relates to Chinese medicine health care product, specifically relate to a kind of formula and processing technology of herbal mixture granule.
Background technology
Herba Dendrobii is containing materials such as polysaccharide, alkaloid, aminoacid, and the trace element such as calcic, potassium, sodium, magnesium, zinc, ferrum, manganese, selenium, copper, chromium, nickel.Through Chinese Medicine institute polyoses content that medicinal plants is identified be 38.974%, total alkaloids is 0.03%, can human body immunity be improved, have special efficacy to organ diseases such as human body eye, pharynx, lung, stomach, intestinal, kidneys.Be used as medicine with it, have and reduce blood glucose, suppression cardiovascular disease, enhancing human body immunity power and anticancer usefulness; With for tea, can cleaning throat and moistening larynx, sore throat relieving improving eyesight, expelling summer-heat QI invigorating, nourishing the stomach heat clearing away, because its effect is peculiar, market is rare, have the title of " Chinese Herba mesonae chinensis ", " Herba Hylothelephii Verticillati ".
Fructus Mori is containing glucose, tannin, succinic acid, cyanidin, calcareous, inorganic salt, vitamin (A, B, C), malic acid, succinic acid, tartaric acid, pigment etc.The blue or green Fructus Mori of immaturity contains cyanic acid, carotene, adenine, choline, Isoquercitrin, trigonelline, ergosterol, vitamin B1, sugar, tannin.
Nature and flavor: sweet; Acid; Cold in nature.Gui Jing: liver; Kidney channel, heart channel.Function cures mainly: nourishing YIN and benefiting blood; Promote the production of body fluid; Intestine moistening.Having a dizzy spell of main deficiency of the liver and kindey and blood deficiency damage of essence; Soreness of waist tinnitus; Early whitening of beard and hair; Insomnia and dreamful sleep; Tianjin wound is thirsty; Quench one's thirst; Dryness of the intestine constipation.
Herba Cistanches contains the compositions such as abundant alkaloid, crystalline neutral substance, aminoacid, trace element, vitamin.Energy kidney-replenishing, benefiting essence-blood, can suppress the appearance of " yang deficiency " symptom, prevent from losing weight.Effectively can prevent, treat the diseases such as male dificiency of kidney sexual impotence, seminal emission premature ejaculation and woman's menoxenia, amenorrhea be infertile.Have nourishing the blood and yin, benefiting QI for activating blood circulation, clear tonifying five ZANG-organs, Yin Yang balancing, QI and blood happy, improve the effects such as body physiological function.
Containing polysaccharide, ucleosides, furan derivative, steroid ferment class, alkaloids, protein, polypeptide, amino acids, triterpenes, sesquiterpene, organic germanium, inorganic salt etc. in the sporophore of Ganoderma, mycelium and spore.Ganoderan is one of principle active component of Ganoderma, has antitumor, immunomodulating, blood sugar lowering, antioxidation, blood fat reducing and anti-aging effects.Triterpenes contained by Ganoderma not lower over one hundred kind, wherein based on tetracyclic triterpenes, the bitterness of Ganoderma is relevant with contained triterpenes.Triterpenes is also one of effective ingredient of Ganoderma, has cytotoxicity to human liver cancer cell, also can suppress the release of histamine, has hepatoprotective effect and has anti-allergic effects etc.
Functional oligose is studied now and is thought and comprise stachyose, cottonseed sugar, isomaltulose, lactulose, oligofructose, oligomeric xylose, oligomeric galactose, oligomeric isomaltose, iMOS, oligomeric dragon gallbladder sugar, soybean oligo saccharide, oligo-chitosan etc.Not being hydrolyzed the enzyme system of their (except isomaltuloses) in human body intestinal canal, thus their not digested absorptions and directly enter large enteral and be preferably bacillus bifidus and utilize, is the multiplicaiton factor of bacillus bifidus.Compared with the oligosaccharide of general (common), functional oligose has unique physiological function: 1. promote bacillus bifidus propagation: functional oligose is the multiplicaiton factor of probiotics in intestinal, wherein the most significantly breeds liking bacillus bifidus.Bacillus bifidus is that one unique in human intestine's flora neither produces endotoxin and do not produce extracellular toxin again, the beneficial microbe with many physiological functions of no pathogenicity; 2. low-yield or zero energy: because human body does not possess the enzyme system of decomposition, digestive function oligosaccharide, therefore functional oligose is difficult to digested or can not absorbs at all, also just energy is not provided to people, and some oligosaccharide is certain sugariness as oligofructose, dextrinosan etc. have, can be used as foodstuff base material to apply in food, like sweet food but the needs that can not eat the people (as diabetes patient, bariatric patients etc.) of sweet food to meet those; 4. prevent constipation: can intestinal peristalsis promoting be stimulated because bifidobacterium fermentation oligosaccharide produces a large amount of short-chain fatty acid, increase the wettability of feces, and by the raised growth of thalline to keep certain osmotic pressure, thus prevent the generation of constipation.In addition oligosaccharide belongs to water soluble dietary fiber, can promote small intestinal peristalsis, also can prevent and alleviate constipation.
It is mutually auxiliary that the monarch and his subjects are particular about by Chinese medicine, reasonable compatibility, and drug effect is complementary, so the curative effect of single use a herb is poor, this compatibility have nourishing the blood and yin, benefiting QI for activating blood circulation, clear tonifying five ZANG-organs, Yin Yang balancing, QI and blood happy, improve the effects such as body physiological function; Overall onset is particular about by Chinese medicine simultaneously, effective ingredient in a herb wants combined effect, so will ensure that all effective ingredient can stripping, because single extracting method and mode are difficult to all the components all effectively stripping, thus single extracting method and the utilizing status of mode to Chinese medicine very poor.
In order under the condition not destroying active ingredient, extract effective ingredient whole in medicine to greatest extent, this extraction process extracts Alcohol soluble composition and water soluble ingredient in two stages, first in the first stage, utilize the edible ethanol of 85% and continuous condensation reflux, extract, device effectively to extract Alcohol soluble composition, ethanol-soluble extractives is separated with residue, and effectively improves the permeability of crude drug cell, add intercellular substance, be beneficial to the extraction of second stage water soluble ingredient.Second stage, adds deionized water, in grinder after crush and grind pulping, under boiling water bath and normal pressure, extracts water soluble ingredient, remains active ingredient and the structure of its crude drug as much as possible.Finally extractum and functional oligose are mixed and made into instant granular, the drug effect of rare Chinese medicine and the probiotic effects of functional oligose are united two into one, be applicable to crowd (especially diabetics and bariatric patients) widely and take.
Retrieval contrast is known: the compound Chinese medicinal preparation containing Herba Dendrobii raw material of studies in China exploitation at present, its medicament composing prescription, dosage form and preparation technology different, the formula and processing technology of the compound Dendrobium huoshanense-cistanchganoderma ganoderma granule that patent application of the present invention relates to is at home there are no bibliographical information, and relate to the compound preparation patent of Herba Dendrobii: application CN201110198864.5, in " a kind of compound dendrobium huoshanense granules and production technology ", the method adopt long High Temperature High Pressure (temperature: 115 DEG C--120 DEG C, pressure: 0.15MPa-0. 2Mpa, time: 15-18h) method extract the water miscible composition of Herba Dendrobii and other compatibility medical material, this certainly will cause loss and the structure change of effective ingredient, and inventor does not do any analysis and explanation to this predictable consequence.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of compound Dendrobium huoshanense-cistanchganoderma ganoderma granule of filling a hole in the market and production technology thereof.This invention achieves reasonable combination to valuable ingredient of Chinese medicine and functional oligose and exploitation, improve Herba Dendrobii, Fructus Mori, the utilization ratio of Herba Cistanches and Ganoderma and effect, effect of rare Chinese medicine and the probiotic effects of functional oligose are united two into one, is applicable to crowd (especially diabetics and bariatric patients) widely and takes.
The scheme that the present invention solves the problems of the technologies described above:
A kind of compound Dendrobium huoshanense-cistanchganoderma ganoderma granule, in its formula, the part by weight of each raw material is: Herba Dendrobii 10%-15%, Fructus Mori 20-25%, Herba Cistanches 5-10%, Ganoderma 5-10%, functional oligose 40-60%.
Preferably, in the formula of compound Dendrobium huoshanense-cistanchganoderma ganoderma granule, the part by weight of each raw material is: Herba Dendrobii 15%, Fructus Mori 25%, Herba Cistanches 10%, Ganoderma 10%, functional oligose 40%.
In the formula of compound Dendrobium huoshanense-cistanchganoderma ganoderma granule, the part by weight of each raw material is: Herba Dendrobii 10%, Fructus Mori 20%, Herba Cistanches 5%, Ganoderma 5%, functional oligose 60%.
In the formula of compound Dendrobium huoshanense-cistanchganoderma ganoderma granule, the part by weight of each raw material is: Herba Dendrobii 10%, Fructus Mori 25%, Herba Cistanches 5%, Ganoderma 5%, functional oligose 55%.
It is wherein a kind of that described functional oligose is selected from oligofructose, oligomeric xylose, oligomeric galactose, oligomeric isomaltose, iMOS, oligomeric dragon gallbladder sugar, soybean oligo saccharide.
The production technology of compound Dendrobium huoshanense-cistanchganoderma ganoderma granule, comprises the steps:
(1) get Herba Dendrobii, Fructus Mori, Herba Cistanches, Ganoderma by formulation ratio, pick remove impurity, cleaning, spreading for cooling, pulverize, cross 40-50 mesh sieve, Fructus Mori need not be pulverized;
(2) Herba Dendrobii, Fructus Mori, Herba Cistanches, Ganoderma add the edible ethanol of 10-15 times amount 85% after stirring, in continuous condensation reflux, extract, device, extract 5-6h, bath temperature is 98-100 DEG C, and negative pressure concentrated extracting solution is to paste, reclaim ethanol, retain filtering residue;
(3) filtering residue in step (2) adds the deionized water of 10-15 times of weight, in grinder after crush and grind pulping, carry 2 times boiling to carry in device boiling respectively, duration is 3-4h respectively, 2-3h, boil the temperature and pressure carried and be respectively boiling water bath and normal pressure, leach cooking liquid filters and merges, and negative pressure is concentrated into paste;
(4) extractum that step (2) and step (3) obtained merges, then negative pressure is concentrated into density is further 1.1x10
3-1.2x10
3kg/m
3;
(5) extractum after concentrated and functional oligose are mixed, make granule, granule can be distributed into bag further or be packaged into capsule.
The condition that described negative pressure meets is :-0.07MPa--0.08Mpa.
Advantage of the present invention is:
1, achieve this valuable ingredient of Chinese medicine of Herba Dendrobii rationally, is effectively developed;
2, efficiently solve the low problem of effective ingredient dissolution rate with techniques such as continuous condensing reflux alcohol extraction and crush and grind water extractions, and ensure that structure and the curative effect of crude drug effective ingredient;
3, be mixed and made into granule with functional oligose after negative pressure concentrates the paste of formation, can take on a small quantity at any time, wash wet suit open and use;
4, this invention is combined by compound recipe, and effectively played the efficacy effect of Herba Dendrobii, Fructus Mori, Herba Cistanches and Ganoderma, test shows, compound preparation is than the effect high several times of unitary agent.
5, rare Chinese medicine and functional oligose compound are made granule, enhance health care effect, be applicable to people widely and take.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, can better understand the present invention and can be implemented, but illustrated embodiment is not as a limitation of the invention to make those skilled in the art.
Embodiment 1
A kind of compound Dendrobium huoshanense-cistanchganoderma ganoderma granule, in its formula, the part by weight of each raw material is: Herba Dendrobii 15%, Fructus Mori 25%, Herba Cistanches 10%, Ganoderma 10%, oligofructose 40%.
The production technology of compound Dendrobium huoshanense-cistanchganoderma ganoderma granule, comprises the steps:
(1) get Herba Dendrobii, Fructus Mori, Herba Cistanches, Ganoderma by formulation ratio, pick remove impurity, cleaning, spreading for cooling, pulverize, cross 40 mesh sieves, Fructus Mori need not be pulverized;
(2) Herba Dendrobii, Fructus Mori, Herba Cistanches, Ganoderma add the edible ethanol of 10 times amount 85% after stirring, and in continuous condensation reflux, extract, device, extract 5h, bath temperature is 98 DEG C, negative pressure concentrated extracting solution is to paste, negative pressure is-0.07MPa, reclaims ethanol, retains filtering residue;
(3) filtering residue in step (2) adds the deionized water of 10 times of weight, in grinder after crush and grind pulping, carry 2 times boiling to carry in device boiling respectively, duration is 3h respectively, 2h, boils the temperature and pressure carried and is respectively boiling water bath and normal pressure, and leach cooking liquid filters and merges, negative pressure is concentrated into paste, and negative pressure is-0.07MPa;
(4) extractum that step (2) and step (3) obtained merges, then negative pressure is concentrated into density is further 1.1x10
3kg/m
3, negative pressure is-0.07MPa;
(5) extractum after concentrated and oligofructose are mixed, make granule, granule can be distributed into bag further or be packaged into capsule.
Embodiment 2
A kind of compound Dendrobium huoshanense-cistanchganoderma ganoderma granule, in its formula, the part by weight of each raw material is: Herba Dendrobii 10%, Fructus Mori 20%, Herba Cistanches 5%, Ganoderma 5%, iMOS 60%.
The production technology of compound Dendrobium huoshanense-cistanchganoderma ganoderma granule, comprises the steps:
(1) get Herba Dendrobii, Fructus Mori, Herba Cistanches, Ganoderma by formulation ratio, pick remove impurity, cleaning, spreading for cooling, pulverize, cross 45 mesh sieves, Fructus Mori need not be pulverized;
(2) Herba Dendrobii, Fructus Mori, Herba Cistanches, Ganoderma add the edible ethanol of 12 times amount 85% after stirring, and in continuous condensation reflux, extract, device, extract 5h, bath temperature is 100 DEG C, negative pressure concentrated extracting solution is to paste, negative pressure is-0.075MPa, reclaims ethanol, retains filtering residue;
(3) filtering residue in step (2) adds the deionized water of 12 times of weight, in grinder after crush and grind pulping, carry 2 times boiling to carry in device boiling respectively, duration is 4h respectively, 3h, boils the temperature and pressure carried and is respectively boiling water bath and normal pressure, and leach cooking liquid filters and merges, negative pressure is concentrated into paste, and negative pressure is-0.075MPa;
(4) extractum that step (2) and step (3) obtained merges, then negative pressure is concentrated into density is further 1.15x10
3kg/m
3, negative pressure is-0.075MPa;
(5) extractum after concentrated and iMOS are mixed, make granule, granule can be distributed into bag further or be packaged into capsule.
Embodiment 3
A kind of compound Dendrobium huoshanense-cistanchganoderma ganoderma granule, in its formula, the part by weight of each raw material is: Herba Dendrobii 10%, Fructus Mori 25%, Herba Cistanches 5%, Ganoderma 5%, soybean oligo saccharide 55%.
The production technology of compound Dendrobium huoshanense-cistanchganoderma ganoderma granule, comprises the steps:
(1) get Herba Dendrobii, Fructus Mori, Herba Cistanches, Ganoderma by formulation ratio, pick remove impurity, cleaning, spreading for cooling, pulverize, cross 50 mesh sieves, Fructus Mori need not be pulverized;
(2) Herba Dendrobii, Fructus Mori, Herba Cistanches, Ganoderma add the edible ethanol of 15 times amount 85% after stirring, and in continuous condensation reflux, extract, device, extract 6h, bath temperature is 100 DEG C, negative pressure concentrated extracting solution is to paste, negative pressure is-0.08MPa, reclaims ethanol, retains filtering residue;
(3) filtering residue in step (2) adds the deionized water of 15 times of weight, in grinder after crush and grind pulping, carry 2 times boiling to carry in device boiling respectively, duration is 4h respectively, 3h, boils the temperature and pressure carried and is respectively boiling water bath and normal pressure, and leach cooking liquid filters and merges, negative pressure is concentrated into paste, and negative pressure is-0.08MPa;
(4) extractum that step (2) and step (3) obtained merges, then negative pressure is concentrated into density is further 1.2x10
3kg/m
3, negative pressure is-0.08MPa;
(5) extractum after concentrated and functional oligose are mixed, make granule, granule can be distributed into bag further or be packaged into capsule.
Embodiment 4
A kind of compound Dendrobium huoshanense-cistanchganoderma ganoderma granule, in its formula, the part by weight of each raw material is: Herba Dendrobii 10%, Folium Rehmanniae 10%, leaf of Caulis Sacchari sinensis 10%, Fructus Trichosanthis leaf 5%, Herba Cistanches 5%, Ganoderma 5%, soybean oligo saccharide 55%.
The production technology of compound Dendrobium huoshanense-cistanchganoderma ganoderma granule, comprises the steps:
(1) get Herba Dendrobii, Folium Rehmanniae, leaf of Caulis Sacchari sinensis, Fructus Trichosanthis leaf, Herba Cistanches, Ganoderma by formulation ratio, pick remove impurity, cleaning, spreading for cooling, pulverize, cross 50 mesh sieves;
(2) Herba Dendrobii, Folium Rehmanniae, leaf of Caulis Sacchari sinensis, Fructus Trichosanthis leaf, Herba Cistanches, Ganoderma add the edible ethanol of 15 times amount 85% after stirring, 6h is extracted in continuous condensation reflux, extract, device, bath temperature is 100 DEG C, negative pressure concentrated extracting solution is to paste, negative pressure is-0.08MPa, reclaim ethanol, retain filtering residue;
(3) filtering residue in step (2) adds the deionized water of 15 times of weight, in grinder after crush and grind pulping, carry 2 times boiling to carry in device boiling respectively, duration is 4h respectively, 3h, boils the temperature and pressure carried and is respectively boiling water bath and normal pressure, and leach cooking liquid filters and merges, negative pressure is concentrated into paste, and negative pressure is-0.08MPa;
(4) extractum that step (2) and step (3) obtained merges, then negative pressure is concentrated into density is further 1.2x10
3kg/m
3, negative pressure is-0.08MPa;
(5) extractum after concentrated and functional oligose are mixed, make granule, granule can be distributed into bag further or be packaged into capsule.
Above formula, works in coordination with and plays a role, enhance the effect of Herba Dendrobii, may be used for diabetic to take.Every day 20-30 mL.Secondary is divided to take.
Case 1:
Lee, man, 53 years old.
Health is tired, loses weight, companion's poor appetite, irritated, insomnia, dry stool sometimes.Blood fat time medical: total sterin 7.6 mmol/l triglyceride 3.3 mmol/l, fasting glucose: 13.2mmol/l, blood glucose 16.3 mmol/l, is diagnosed as type Ⅱdiabetes mellitus after meal.Coordinate do appropriate exercise every day, then give the present embodiment after three months, blood glucose declines to some extent, and survey its fasting glucose 6.5 mmol/l, 2 hours blood glucoses are 7.8 mmol/l after meal, and after half a year, follow-up is healed.
Case 2:
Lee so-and-so, female, 63 years old.
Headache dreaminess, companion's poor appetite, irritated, appetite increases, and loses weight.Fasting glucose: 10.8mmol/l, after meal blood glucose 15.6mmol/l time medical.Give the present embodiment more after two months, blood glucose declines to some extent, and myasthenia of limbs sense disappears, and surveys its fasting glucose 6.3 mmol/l, 2 hours blood glucoses are 7.6 mmol/l after meal, suggestion diet should be light, adjusts smooth emotion, eat vegetable and fruit more, suitable exercise, after half a year, follow-up is healed, and health is fine so far, glucostasis.
Case 3:
Wu so-and-so, man, 56 years old.
Numb limbs and tense tendons, uncomfortable in chest, headache dreaminess, irritated, insomnia, red and uncoated tongue, deep and stringy pulse.Give the present embodiment after three months, blood glucose declines to some extent, and survey its fasting glucose 6.4 mmol/l, 2 hours blood glucoses are 8.6mmol/l after meal, and after half a year, follow-up is healed, and glucostasis, blood fat are normal.
Although the foregoing describe the specific embodiment of the present invention; but be familiar with those skilled in the art to be to be understood that; specific embodiment described by us is illustrative; instead of for the restriction to scope of the present invention; those of ordinary skill in the art, in the modification of the equivalence done according to spirit of the present invention and change, should be encompassed in scope that claim of the present invention protects.
Claims (6)
1. a compound Dendrobium huoshanense-cistanchganoderma ganoderma granule, is characterized in that: in its formula, the part by weight of each raw material is: Herba Dendrobii 10-15%, Fructus Mori 20-25%, Herba Cistanches 5-10%, Ganoderma 5-10%, functional oligose 40-60%; The production technology of described compound Dendrobium huoshanense-cistanchganoderma ganoderma granule, comprises the steps:
(1) get Herba Dendrobii, Fructus Mori, Herba Cistanches, Ganoderma by formulation ratio, pick remove impurity, cleaning, spreading for cooling, Herba Dendrobii, Herba Cistanches and Ganoderma are pulverized, cross 40-50 mesh sieve, Fructus Mori need not be pulverized;
(2) Herba Dendrobii, Fructus Mori, Herba Cistanches, Ganoderma add the edible ethanol of 10-15 times amount 85% after stirring, in continuous condensation reflux, extract, device, extract 5-6h, bath temperature is 98-100 DEG C, and negative pressure concentrated extracting solution is to paste, reclaim ethanol, retain filtering residue;
(3) filtering residue in step (2) adds the deionized water of 10-15 times of weight, in grinder after crush and grind pulping, carry 2 times boiling to carry in device boiling respectively, duration is 3-4h respectively, 2-3h, boil the temperature and pressure carried and be respectively boiling water bath and normal pressure, leach cooking liquid filters and merges, and negative pressure is concentrated into paste;
(4) extractum that step (2) and step (3) obtained merges, then negative pressure is concentrated into density is further 1.1 × 10
3-1.2 × 10
3kg/m
3;
(5) extractum after concentrated and functional oligose are mixed, make granule, granule can be distributed into bag further or be packaged into capsule.
2. a kind of compound Dendrobium huoshanense-cistanchganoderma ganoderma granule according to claim 1, is characterized in that: in the formula of described compound Dendrobium huoshanense-cistanchganoderma ganoderma granule, the part by weight of each raw material is: Herba Dendrobii 15%, Fructus Mori 25%, Herba Cistanches 10%, Ganoderma 10%, functional oligose 40%.
3. a kind of compound Dendrobium huoshanense-cistanchganoderma ganoderma granule according to claim 1, is characterized in that: in the formula of described compound Dendrobium huoshanense-cistanchganoderma ganoderma granule, the part by weight of each raw material is: Herba Dendrobii 10%, Fructus Mori 20%, Herba Cistanches 5%, Ganoderma 5%, functional oligose 60%.
4. a kind of compound Dendrobium huoshanense-cistanchganoderma ganoderma granule according to claim 1, is characterized in that: in the formula of described compound Dendrobium huoshanense-cistanchganoderma ganoderma granule, the part by weight of each raw material is: Herba Dendrobii 10%, Fructus Mori 25%, Herba Cistanches 5%, Ganoderma 5%, functional oligose 55%.
5., according to a kind of compound Dendrobium huoshanense-cistanchganoderma ganoderma granule described in claim 1, it is characterized in that: it is wherein a kind of that described functional oligose is selected from oligofructose, oligomeric xylose, oligomeric galactose, oligomeric isomaltose, iMOS, oligomeric dragon gallbladder sugar, soybean oligo saccharide.
6. according to a kind of compound Dendrobium huoshanense-cistanchganoderma ganoderma granule described in claim 1, it is characterized in that: the condition that described negative pressure meets is :-0.07MPa--0.08MPa.
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