CN110354204B - Composition with eyesight improving effect and preparation and application methods thereof - Google Patents

Composition with eyesight improving effect and preparation and application methods thereof Download PDF

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CN110354204B
CN110354204B CN201910783559.9A CN201910783559A CN110354204B CN 110354204 B CN110354204 B CN 110354204B CN 201910783559 A CN201910783559 A CN 201910783559A CN 110354204 B CN110354204 B CN 110354204B
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mulberry
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improving effect
powder
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CN110354204A (en
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于银行
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Yu Yinxing
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Muling Shengyu Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
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    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482—Cassia, e.g. golden shower tree
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    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The invention discloses a composition with an eyesight improving effect and a preparation method thereof, wherein the composition with the eyesight improving effect comprises the following raw materials: cassia seed, chrysanthemum, medlar, honeysuckle, mulberry leaf, dandelion, polygonatum, emblic leafflower fruit, mulberry, blueberry powder, lutein ester, vitamin C, vitamin E, beta-carotene, sodium citrate, sucralose and potassium sorbate. The invention has the beneficial effects that: the composition with the eyesight improving effect can protect eyes from being damaged by light, inhibit the reaction of lipid peroxide in the crystalline lens of the eyes so as to improve the blood circulation of the eyes, and prevent various degenerative diseases caused by aging and senility; also has effects of nourishing liver, protecting liver, replenishing qi and blood, relieving fatigue, and improving blood circulation in vivo to improve eyesight and dredging collaterals.

Description

Composition with eyesight improving effect and preparation and application methods thereof
Technical Field
The invention relates to a composition with an eyesight improving effect and preparation and application methods thereof.
Background
The eye, also known as the eye, is the visual organ that receives light and forms images on the brain, which is one of the very delicate and important sensory organs of the human body. To capture the light message, the eye must be exposed to the body surface, which increases its probability of being attacked by trauma and external pathogens. The core of window and beauty of the eye call Xinling is that people are increasingly demanding on eye care, protecting eyesight, preventing eye diseases and caring eyes, and the core is the subject of more and more attention.
With the popularization of computers and mobile phones along with the development of society, more and more people can face a computer screen for a long time or stare at the mobile phone for a long time, so that eyes are dry and easy to fatigue, and more serious diseases such as myopia, cataract, glaucoma, retinal detachment and the like can be caused. The eye overuse condition of people is more serious, and the eye protection problem is more prominent.
The eye problems relate to aspects, not only the eye hygiene problem, but also the mood, the constitution and the environment. The traditional Chinese medicine often says 'calming heart and improving eyesight, clearing liver and improving eyesight' in the traditional Chinese medicine, and there is a saying 'eyes can be seen by blood' because heart and liver open into eyes and meridians run upwards to eyes. Such as dysphoria, excessive internal heat, insomnia, bloody eyes, photophobia, lacrimation, physical condition, emotional mood, light pollution, electromagnetic wave, etc., can affect the health of eyes.
The existing liver-protecting or liver-clearing and vision-improving medicines in the market are various, but most of the medicines are western medicines, and various eye drops are inexhaustible, but the eye diseases can be only temporarily relieved, and the effects of clearing liver and improving vision cannot be fundamentally achieved.
Disclosure of Invention
The invention aims to provide a composition which can relieve eye discomfort caused by long-term use of eyes and has the effect of improving eyesight, and a preparation method and an application method thereof.
The composition with the eyesight improving effect comprises the following raw materials in parts by weight: 4-6 parts of cassia seed, 5-15 parts of chrysanthemum, 5-15 parts of medlar, 4-6 parts of honeysuckle, 5-15 parts of mulberry leaf, 5-15 parts of dandelion, 5-15 parts of polygonatum, 5-15 parts of emblic leafflower fruit, 5-15 parts of mulberry, 5-15 parts of blueberry powder, 0.1-0.4 part of lutein ester, 0.3-0.6 part of vitamin C, 0.3-0.6 part of vitamin E, 0.1-0.3 part of beta-carotene, 0.04-0.06 part of sodium citrate, 0.04-0.06 part of sucralose and 0.04-0.06 part of potassium sorbate.
Further, the composition with the eyesight improving effect comprises the following raw materials in parts by weight: 4-5 parts of cassia seed, 8-12 parts of chrysanthemum, 8-12 parts of medlar, 4-5 parts of honeysuckle, 8-12 parts of mulberry leaf, 8-12 parts of dandelion, 8-12 parts of polygonatum, 8-12 parts of emblic leafflower fruit, 8-12 parts of mulberry, 8-12 parts of blueberry powder, 0.2-0.3 part of lutein ester, 0.4-0.5 part of vitamin C, 0.4-0.5 part of vitamin E, 0.1-0.2 part of beta-carotene, 0.04-0.05 part of sodium citrate, 0.04-0.05 part of sucralose and 0.04-0.05 part of potassium sorbate.
Further, the composition with the eyesight improving effect comprises the following raw materials in parts by weight: 2 parts of cassia seed, 10 parts of chrysanthemum, 10 parts of medlar, 5 parts of honeysuckle, 10 parts of mulberry leaf, 10 parts of dandelion, 10 parts of polygonatum, 10 parts of emblic leafflower fruit, 10 parts of mulberry, 10 parts of blueberry powder, 0.2 part of lutein ester, 0.5 part of vitamin C, 0.5 part of vitamin E, 0.2 part of beta-carotene, 0.05 part of sodium citrate, 0.05 part of sucralose and 0.05 part of potassium sorbate.
The preparation method of the composition with the eyesight improving effect comprises the following steps:
(1) preparing a cassia seed extract;
(2) crushing mulberry to obtain mulberry fruit paste, freeze-drying the mulberry fruit paste to obtain mulberry dry powder, grinding the mulberry dry powder, and sieving to obtain mulberry powder;
(3) adding water into the mixture of flos Chrysanthemi, fructus Lycii, flos Lonicerae, folium Mori, herba Taraxaci, rhizoma Polygonati Odorati, and fructus Phyllanthi, heating and reflux-extracting the effective components in the mixture, filtering after heating, concentrating the filtrate, and drying to obtain effective component powder;
(4) and mixing and uniformly stirring the cassia seed extract, the mulberry powder, the effective component powder, the blueberry powder, lutein ester, vitamin C, vitamin E, beta-carotene, sodium citrate, sucralose and potassium sorbate to obtain the composition with the eyesight improving effect.
Further, in the step (1), the preparation method of the cassia seed extract comprises the following steps:
a. pulverizing semen Cassiae to obtain semen Cassiae powder;
b. adding petroleum ether into semen Cassiae powder, reflux-extracting until the extractive solution is colorless, filtering the extractive solution to remove filtrate to obtain intermediate product;
c. drying the intermediate product, adding ethanol into the intermediate product, reflux-extracting, filtering the extractive solution to remove residue, concentrating the filtrate, and drying to obtain semen Cassiae extract.
Further, in the step c, the concentration of the ethanol is 70-75%.
Further, in the step (2), the freeze drying is as follows: drying at-30 deg.C to-40 deg.C for 24-40 h.
Further, in the step (3), the drying temperature is 60-80 ℃, and the drying time is 8-12 h.
Further, in the step (4), the fineness of the composition with eyesight improving effect is 100-150 meshes.
The composition with the eyesight improving effect is applied to health products, foods and medicines.
The cassia seed is named as dried mature seed of cassia tora or cassia tora of leguminous plants, is bitter in taste and sweet in nature, has the effects of improving eyesight, relaxing bowel, reducing fat, improving eyesight, and treating constipation, hyperlipidemia and hypertension.
Chrysanthemum is a perennial root herb of the genus Chrysanthemum of the family Compositae in plant taxonomy. The chrysanthemum has the functions of dispelling wind and calming the liver, and has the auxiliary treatment effect on cold and headache by smelling. The chrysanthemum soaked in water has good effects of protecting eyes and improving eyesight, and has the effects of clearing away heat and toxic materials, enhancing the body resistance and reducing swelling; the chrysanthemum contains rich vitamin A, the substance can well protect the skin and simultaneously enable the head of a person to be more clear, and the chrysanthemum also has the effect of removing moisture in the body; in addition, the chrysanthemum contains flavonoid antioxidant of luteolin, the flavonoid antioxidant can effectively kill cancer cells in a centralized way, and the chrysanthemum tea can well prevent cancer after being frequently drunk.
The fructus Lycii is mature fruit of fructus Lycii of Solanaceae, and contains abundant carotene, vitamins and fructus Lycii polysaccharide. The carotene contained in the medlar can be converted into vitamin A in a human body, the vitamin A can improve the vision of people, and the vitamin A has the function of maintaining the normal growth and differentiation of epithelial tissues; the fructus Lycii polysaccharide is a water-soluble polysaccharide, has physiological activity, and can enhance nonspecific immunity, improve disease resistance, and inhibit tumor growth and cell mutation. In addition, fructus Lycii has functions of resisting Y-ray radiation and protecting organism, and can be used as adjuvant medicine for anti-tumor therapy, improving therapeutic effect, and protecting organism immunity.
Honeysuckle, also known as Lonicera japonica (Leonurus chinensis), is sweet and slightly bitter in nature, has certain inhibitory effect on various pathogenic bacteria such as staphylococcus aureus, hemolytic streptococcus, escherichia coli, dysentery bacillus, vibrio cholerae, typhoid bacillus, paratyphoid bacillus and the like, and also has the effect of strengthening the immune function and promoting the phagocytic function of white blood cells and inflammatory cells. In addition, the honeysuckle contains trace elements and chemical components which are necessary for human bodies, and also contains a plurality of active enzyme substances which are beneficial to the human bodies, thereby having good effects of resisting aging, preventing canceration, and reducing weight and building bodies.
The mulberry leaves are dry leaves of mulberry of the family Moraceae, have the effects of dispelling wind and heat, clearing lung and moistening dryness, and clearing liver and improving eyesight, have the functions of tonifying and resisting aging similar to ginseng in the mulberry leaves, can stabilize the functions of a nervous system, relieve emotional agitation caused by physiological changes, improve the activity of superoxide dismutase in vivo, prevent harmful substances in vivo from generating, reduce or eliminate lipofuscin which is generated and accumulated in the body, and prevent oxidative damage by inhibiting or eliminating free radicals in the components such as quercetin, phenolic compounds, vitamin C and the like contained in the mulberry leaves.
Taraxacum plants belonging to Taraxacum of Compositae contain various health nutritional components such as taraxanol, taraxacin, choline, organic acid, and inulin. The dandelion contains abundant carotene and mineral substances, and has the effects of improving dyspepsia and constipation, clearing away heat and toxic materials, relieving swelling and removing toxic materials, relieving swelling and resolving masses, and promoting lactation, and is very effective in treating mastitis.
Rhizoma Polygonati Odorati is a perennial herb of Liliaceae, and has effects of nourishing yin, moistening dryness, clearing heat, promoting fluid production, and relieving cough. It can be used as tonic medicine for treating fever with yin deficiency, cough due to deficiency heat, heart disease, diabetes, and tuberculosis.
The emblic leafflower fruit has the effects of resisting oxidation and aging, can protect blood vessels and enables the body to have stronger oxidation resistance; it also has effects in protecting liver, preventing alcohol damage to liver, and preventing acute hepatitis. The butanol substance contained in the emblic leafflower fruit can resist gastrointestinal ulcer and well protect gastric mucosa from being damaged.
The mulberry is a fruit of mulberry, also called mulberry and mulberry fruit, contains rich active protein, vitamins, amino acid, carotene, mineral substances and other ingredients, and is beneficial to the medical field that the mulberry can obviously improve the immunity of human bodies and has the effects of delaying senility and beautifying the face when being eaten frequently as the best health care fruit product of twenty-first century. In addition, the mulberry also has the effects of tonifying deficiency and qi, removing moisture, reducing blood pressure, clearing liver and improving vision.
The blueberry fruit contains rich nutrient components, especially anthocyanin, and has good nutrition and health care effects, and also has the functions of preventing cranial nerve aging, strengthening heart, resisting cancer, softening blood vessels, enhancing human immunity and the like. The blueberry contains a great amount of potassium, the potassium can help to maintain the balance of liquid in a body and normal blood pressure and heart function, and the blueberry also has the function of resisting free radicals, can reduce the damage of oxygen free radical multiple cell membranes, DNA and other cell components, prevents functional disorder in the body and enhances the immunity and disease resistance of a human body.
The lutein ester is an important carotenoid fatty acid ester and is a key nutrient element for helping eye development, and the lutein ester can supplement the macular pigment density in the macular region of the retina of a human eye, protect macula lutea, promote the macular development, protect eyes from light damage, delay the aging of the eyes and prevent pathological changes.
Vitamin C is formed by antibody and collagen, can maintain immune function, keep the integrity of blood vessels, promote non-heme iron absorption and the like, and simultaneously has the effects of resisting oxidation, resisting free radicals and inhibiting tyrosinase formation, thereby achieving the effects of whitening and fading spots.
Vitamin E is a fat-soluble vitamin whose hydrolysate is tocopherol, one of the most important antioxidants. Vitamin E can promote reproduction, promote secretion of sex hormone, increase sperm motility and number of male, increase female estrogen concentration, improve fertility, and prevent abortion. Can inhibit lipid peroxide reaction in eye lens, dilate peripheral blood vessel, improve blood circulation, and prevent myopia occurrence and development.
Beta-carotene is one of the carotenoids, also an orange fat-soluble compound, and also the most commonly occurring natural pigment in nature. Is an antioxidant, has detoxifying effect, is an indispensable nutrient for maintaining human health, has remarkable functions in resisting cancer, preventing cardiovascular diseases and cataract, resisting oxidation, and further prevents various degenerative diseases caused by aging and aging.
Sodium citrate is an organic compound, white to colorless in appearance, and is used as an acidity regulator, a flavoring agent, and a stabilizer in the food and beverage industry.
The invention has the beneficial effects that: the composition with the eyesight improving effect can protect eyes from being damaged by light, inhibit the reaction of lipid peroxide in the crystalline lens of the eyes so as to improve the blood circulation of the eyes, and prevent various degenerative diseases caused by aging and senility; also has effects of nourishing liver, protecting liver, replenishing qi and blood, relieving fatigue, and improving blood circulation in vivo to improve eyesight and dredging collaterals.
Detailed Description
Example 1
The composition with the eyesight improving effect comprises the following raw materials in parts by weight: 4kg of cassia seed, 5kg of chrysanthemum, 5kg of medlar, 4kg of honeysuckle, 5kg of mulberry leaf, 5kg of dandelion, 5kg of polygonatum, 5kg of emblic leafflower fruit, 5kg of mulberry, 5kg of blueberry powder, 0.1kg of lutein ester, 0.3kg of vitamin C, 0.3kg of vitamin E, 0.1kg of beta-carotene, 0.04kg of sodium citrate, 0.04kg of sucralose and 0.04kg of potassium sorbate.
The preparation method of the composition with the eyesight improving effect comprises the following steps:
(1) preparing a cassia seed extract;
(2) crushing mulberry to obtain mulberry fruit paste, freeze-drying the mulberry fruit paste to obtain mulberry dry powder, grinding the mulberry dry powder, and sieving to obtain mulberry powder;
(3) adding water into the mixture of flos Chrysanthemi, fructus Lycii, flos Lonicerae, folium Mori, herba Taraxaci, rhizoma Polygonati Odorati, and fructus Phyllanthi, heating and reflux-extracting the effective components in the mixture, filtering after heating, concentrating the filtrate, and drying to obtain effective component powder;
(4) and mixing and uniformly stirring the cassia seed extract, the mulberry powder, the effective component powder, the blueberry powder, lutein ester, vitamin C, vitamin E, beta-carotene, sodium citrate, sucralose and potassium sorbate to obtain the composition with the eyesight improving effect.
Example 2
The composition with the eyesight improving effect comprises the following raw materials in parts by weight: 4kg of cassia seed, 8kg of chrysanthemum, 8kg of medlar, 4kg of honeysuckle, 8kg of mulberry leaf, 8kg of dandelion, 8kg of polygonatum, 8kg of emblic leafflower fruit, 8kg of mulberry, 8kg of blueberry powder, 0.2kg of lutein ester, 0.4kg of vitamin C, 0.4kg of vitamin E, 0.1kg of beta-carotene, 0.04kg of sodium citrate, 0.04kg of sucralose and 0.04kg of potassium sorbate.
The preparation method of the composition with the eyesight improving effect comprises the following steps:
(1) preparing a cassia seed extract;
pulverizing semen Cassiae to obtain semen Cassiae powder;
adding petroleum ether into semen Cassiae powder, reflux-extracting until the extractive solution is colorless, filtering the extractive solution to remove filtrate to obtain intermediate product;
drying the intermediate product, adding 70% ethanol into the intermediate product, reflux extracting, filtering the extractive solution to remove residue, concentrating the filtrate, and drying to obtain semen Cassiae extract;
(2) crushing mulberry to obtain mulberry fruit paste, freeze-drying the mulberry fruit paste at the temperature of-30 ℃ for 24 hours to obtain mulberry dry powder, grinding the mulberry dry powder, and sieving to obtain the mulberry powder;
(3) adding water into the mixture of flos Chrysanthemi, fructus Lycii, flos Lonicerae, folium Mori, herba Taraxaci, rhizoma Polygonati Odorati, and fructus Phyllanthi, heating and reflux-extracting the effective components in the mixture, filtering after heating, concentrating the filtrate, and drying at 60 deg.C for 8 hr to obtain effective component powder;
(4) mixing semen Cassiae extract, Mori fructus powder, effective constituent powder, fructus Myrtilli powder, lutein ester, vitamin C, vitamin E, beta-carotene, sodium citrate, sucralose and potassium sorbate, and stirring to obtain composition with fineness of 100 meshes and eyesight improving effect.
The composition with the eyesight improving effect can be applied to the aspects of health products, foods and medicines.
Example 3
The composition with the eyesight improving effect comprises the following raw materials in parts by weight: 2kg of cassia seed, 10kg of chrysanthemum, 10kg of medlar, 5kg of honeysuckle, 10kg of mulberry leaf, 10kg of dandelion, 10kg of polygonatum, 10kg of emblic leafflower fruit, 10kg of mulberry, 10kg of blueberry powder, 0.2kg of lutein ester, 0.5kg of vitamin C, 0.5kg of vitamin E, 0.2kg of beta-carotene, 0.05kg of sodium citrate, 0.05kg of sucralose and 0.05kg of potassium sorbate.
The preparation method of the composition with the eyesight improving effect comprises the following steps:
(1) preparing a cassia seed extract;
pulverizing semen Cassiae to obtain semen Cassiae powder;
adding petroleum ether into semen Cassiae powder, reflux-extracting until the extractive solution is colorless, filtering the extractive solution to remove filtrate to obtain intermediate product;
drying the intermediate product, adding 72% ethanol into the intermediate product, reflux extracting, filtering the extractive solution to remove residue, concentrating the filtrate, and drying to obtain semen Cassiae extract;
(2) crushing mulberry to obtain mulberry fruit paste, freeze-drying the mulberry fruit paste at the temperature of-35 ℃ for 30h to obtain mulberry dry powder, grinding the mulberry dry powder, and sieving to obtain the mulberry powder;
(3) adding water into the mixture of flos Chrysanthemi, fructus Lycii, flos Lonicerae, folium Mori, herba Taraxaci, rhizoma Polygonati Odorati, and fructus Phyllanthi, heating and reflux-extracting the effective components in the mixture, filtering after heating, concentrating the filtrate, and drying at 65 deg.C for 11 hr to obtain effective component powder;
(4) mixing semen Cassiae extract, Mori fructus powder, effective constituent powder, fructus Myrtilli powder, lutein ester, vitamin C, vitamin E, beta-carotene, sodium citrate, sucralose and potassium sorbate, and stirring to obtain 120 mesh composition with eyesight improving effect.
The composition with the eyesight improving effect can be applied to the aspects of health products, foods and medicines.
Example 4
The composition with the eyesight improving effect comprises the following raw materials in parts by weight: 5kg of cassia seed, 12kg of chrysanthemum, 12kg of medlar, 5kg of honeysuckle, 12kg of mulberry leaf, 12kg of dandelion, 12kg of polygonatum, 12kg of emblic leafflower fruit, 12kg of mulberry, 12kg of blueberry powder, 0.3kg of lutein ester, 0.5kg of vitamin C, 0.5kg of vitamin E, 0.2kg of beta-carotene, 0.05kg of sodium citrate, 0.05kg of sucralose and 0.05kg of potassium sorbate.
The preparation method of the composition with the eyesight improving effect comprises the following steps:
(1) preparing a cassia seed extract;
pulverizing semen Cassiae to obtain semen Cassiae powder;
adding petroleum ether into semen Cassiae powder, reflux-extracting until the extractive solution is colorless, filtering the extractive solution to remove filtrate to obtain intermediate product;
drying the intermediate product, adding 73% ethanol into the intermediate product, reflux extracting, filtering the extractive solution to remove residue, concentrating the filtrate, and drying to obtain semen Cassiae extract;
(2) crushing mulberry to obtain mulberry fruit paste, freeze-drying the mulberry fruit paste at-38 ℃ for 36h to obtain mulberry dry powder, grinding the mulberry dry powder, and sieving to obtain the mulberry powder;
(3) adding water into the mixture of flos Chrysanthemi, fructus Lycii, flos Lonicerae, folium Mori, herba Taraxaci, rhizoma Polygonati Odorati, and fructus Phyllanthi, heating and reflux-extracting the effective components in the mixture, filtering after heating, concentrating the filtrate, and drying at 75 deg.C for 10 hr to obtain effective component powder;
(4) mixing semen Cassiae extract, Mori fructus powder, effective constituent powder, fructus Myrtilli powder, lutein ester, vitamin C, vitamin E, beta-carotene, sodium citrate, sucralose and potassium sorbate, and stirring to obtain 130 mesh composition with eyesight improving effect.
The composition with the eyesight improving effect can be applied to the aspects of health products, foods and medicines.
Example 5
The composition with the eyesight improving effect comprises the following raw materials in parts by weight: 6kg of cassia seed, 15kg of chrysanthemum, 15kg of medlar, 6kg of honeysuckle, 15kg of mulberry leaf, 15kg of dandelion, 15kg of polygonatum, 15kg of emblic leafflower fruit, 15kg of mulberry, 15kg of blueberry powder, 0.4kg of lutein ester, 0.6kg of vitamin C, 0.6kg of vitamin E, 0.3kg of beta-carotene, 0.06kg of sodium citrate, 0.06kg of sucralose and 0.06kg of potassium sorbate.
The preparation method of the composition with the eyesight improving effect comprises the following steps:
(2) preparing a cassia seed extract;
pulverizing semen Cassiae to obtain semen Cassiae powder;
adding petroleum ether into semen Cassiae powder, reflux-extracting until the extractive solution is colorless, filtering the extractive solution to remove filtrate to obtain intermediate product;
drying the intermediate product, adding 75% ethanol into the intermediate product, reflux extracting, filtering the extractive solution to remove residue, concentrating the filtrate, and drying to obtain semen Cassiae extract;
(2) crushing mulberry to obtain mulberry fruit paste, freeze-drying the mulberry fruit paste at the temperature of-40 ℃ for 40h to obtain mulberry dry powder, grinding the mulberry dry powder, and sieving to obtain the mulberry powder;
(3) adding water into the mixture of flos Chrysanthemi, fructus Lycii, flos Lonicerae, folium Mori, herba Taraxaci, rhizoma Polygonati Odorati, and fructus Phyllanthi, heating and reflux-extracting the effective components in the mixture, filtering after heating, concentrating the filtrate, and drying at 80 deg.C for 8 hr to obtain effective component powder;
(4) mixing semen Cassiae extract, Mori fructus powder, effective constituent powder, fructus Myrtilli powder, lutein ester, vitamin C, vitamin E, beta-carotene, sodium citrate, sucralose and potassium sorbate, and stirring to obtain 150-mesh composition with eyesight improving effect.
The composition with the eyesight improving effect can be applied to the aspects of health products, foods and medicines.
Comparative example 1
The composition for improving eyesight as described in comparative example 1, which does not include Yuzhu and Yuganzi, is prepared by the same method as example 3 except for the raw materials, weight parts and the like.
Comparative example 2
The composition for improving eyesight as shown in comparative example 2 comprises the same raw materials and weight parts as those of example 3, the cassia seed extract as shown in comparative example 2 is prepared by directly extracting with ethanol under reflux, and the rest steps are the same as those of example 3.
The composition with the eyesight improving effect has the following effect research:
selecting 150 patients with asthenopia symptoms, wherein the clinical symptoms comprise eye swelling, eye pain, photophobia, dry eye and the like, averagely dividing the patients into 3 groups, and taking a test group, a control group 1 and a control group 2, wherein the test group takes the composition with the eyesight improving effect of the invention, the control group 1 takes the composition with the eyesight improving effect of the comparative example 1, and the control group 2 takes the composition with the eyesight improving effect of the comparative example 2; the dietary habits and daily lives of the subjects were the same as before the subjects 2 times a day, 3g each time, during the test period, no treatment was allowed for the eyes, and the test effect was measured after two weeks, with the results shown in table 1:
TABLE 1
Figure BDA0002177299230000111
Remarking: the effective finger indicates that the symptoms of eye swelling disappear, eyes do not feel sore any more, and phenomena of dryness and photophobia do not occur any more.
As can be seen from table 1, the composition with eyesight improving effect of the present invention has good efficacy in treating eye swelling, eye soreness, photophobia and dry eye, and the effective rate can reach 86%; while the effective rate of the control group 1 (the raw materials do not contain polygonatum odoratum and emblic leafflower fruit) is obviously reduced, the highest effective rate is 32%, and the polygonatum odoratum, the emblic leafflower fruit and the other raw materials in the composition provided by the invention play a synergistic effect, so that the treatment effect is improved.
The effective rate of the contrast group 2 is slightly reduced compared with that of the test group, the contrast group 2 adopts direct ethanol reflux extraction when extracting the cassia seed extract, and the invention adopts the steps of firstly adopting petroleum ether to extract until the extract is colorless, and then adopting ethanol to extract, thus the extraction method of the cassia seed extract enhances the effect of the cassia seed on improving eyesight.
The present invention is not limited to the above-described preferred embodiments, and various other forms of the product can be obtained by anyone who has come within the teachings of the present invention, but any variation in the details thereof, which is the same as or similar to the present application, falls within the scope of the present invention.

Claims (8)

1. The composition with the eyesight improving effect is characterized by comprising the following raw materials in parts by weight: 4-6 parts of cassia seed, 5-15 parts of chrysanthemum, 5-15 parts of medlar, 4-6 parts of honeysuckle, 5-15 parts of mulberry leaf, 5-15 parts of dandelion, 5-15 parts of polygonatum, 5-15 parts of emblic leafflower fruit, 5-15 parts of mulberry, 5-15 parts of blueberry powder, 0.1-0.4 part of lutein ester, 0.3-0.6 part of vitamin C, 0.3-0.6 part of vitamin E, 0.1-0.3 part of beta-carotene, 0.04-0.06 part of sodium citrate, 0.04-0.06 part of sucralose and 0.04-0.06 part of potassium sorbate;
the preparation method of the composition with the eyesight improving effect comprises the following steps:
(1) preparing a cassia seed extract:
a. pulverizing semen Cassiae to obtain semen Cassiae powder;
b. adding petroleum ether into semen Cassiae powder, reflux-extracting until the extractive solution is colorless, filtering the extractive solution to remove filtrate to obtain intermediate product;
c. drying the intermediate product, adding ethanol into the intermediate product, reflux-extracting, filtering the extractive solution to remove residue, concentrating the filtrate, and drying to obtain semen Cassiae extract;
(2) crushing mulberry to obtain mulberry fruit paste, freeze-drying the mulberry fruit paste to obtain mulberry dry powder, grinding the mulberry dry powder, and sieving to obtain mulberry powder;
(3) adding water into the mixture of flos Chrysanthemi, fructus Lycii, flos Lonicerae, folium Mori, herba Taraxaci, rhizoma Polygonati Odorati, and fructus Phyllanthi, heating and reflux-extracting the effective components in the mixture, filtering after heating, concentrating the filtrate, and drying to obtain effective component powder;
(4) and mixing and uniformly stirring the cassia seed extract, the mulberry powder, the effective component powder, the blueberry powder, lutein ester, vitamin C, vitamin E, beta-carotene, sodium citrate, sucralose and potassium sorbate to obtain the composition with the eyesight improving effect.
2. The composition with the eyesight improving effect according to claim 1, is characterized by comprising the following raw materials in parts by weight: 4-5 parts of cassia seed, 8-12 parts of chrysanthemum, 8-12 parts of medlar, 4-5 parts of honeysuckle, 8-12 parts of mulberry leaf, 8-12 parts of dandelion, 8-12 parts of polygonatum, 8-12 parts of emblic leafflower fruit, 8-12 parts of mulberry, 8-12 parts of blueberry powder, 0.2-0.3 part of lutein ester, 0.4-0.5 part of vitamin C, 0.4-0.5 part of vitamin E, 0.1-0.2 part of beta-carotene, 0.04-0.05 part of sodium citrate, 0.04-0.05 part of sucralose and 0.04-0.05 part of potassium sorbate.
3. The composition with the eyesight improving effect according to claim 1, is characterized by comprising the following raw materials in parts by weight: 2 parts of cassia seed, 10 parts of chrysanthemum, 10 parts of medlar, 5 parts of honeysuckle, 10 parts of mulberry leaf, 10 parts of dandelion, 10 parts of polygonatum, 10 parts of emblic leafflower fruit, 10 parts of mulberry, 10 parts of blueberry powder, 0.2 part of lutein ester, 0.5 part of vitamin C, 0.5 part of vitamin E, 0.2 part of beta-carotene, 0.05 part of sodium citrate, 0.05 part of sucralose and 0.05 part of potassium sorbate.
4. The composition for improving eyesight according to claim 1, wherein the concentration of ethanol in step c is 70% to 75%.
5. The composition with eyesight improving effect according to claim 1, wherein in the step (2), the freeze-drying is: drying at-30 deg.C to-40 deg.C for 24-40 h.
6. The composition with eyesight improving effect according to claim 1, wherein the drying temperature in step (3) is 60-80 ℃ and the drying time is 8-12 h.
7. The composition with eyesight improving effect as claimed in claim 1, wherein in step (4), the fineness of the composition with eyesight improving effect is 100-150 meshes.
8. Use of a composition according to any one of claims 1 to 3 for the preparation of a medicament having eyesight improving effect.
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102048201A (en) * 2009-11-09 2011-05-11 樊宝顺 Novel fruit and vegetable beverage
CN103053746A (en) * 2012-12-28 2013-04-24 崇左市江州区生产力促进中心 Vision-improving tea and production method thereof
CN106942532A (en) * 2016-01-07 2017-07-14 吕学栋 It is a kind of that there is the beverage for protecting vision performance

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102048201A (en) * 2009-11-09 2011-05-11 樊宝顺 Novel fruit and vegetable beverage
CN103053746A (en) * 2012-12-28 2013-04-24 崇左市江州区生产力促进中心 Vision-improving tea and production method thereof
CN106942532A (en) * 2016-01-07 2017-07-14 吕学栋 It is a kind of that there is the beverage for protecting vision performance

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
决明子对老龄大鼠晶状体抗氧化作用的有效活性部位研究;王彩萍;《山西中医学院学报》;山西中医学院学报;20101231;第12-13、23页 *
浮云的泪5cl.蒲公英+金银花+决明子能一起泡水吗？这样有什么作用？.《https://zhidao.baidu.com/question/1796417085301629027.html，浮云的泪5cl》.2014, *
蒲公英+金银花+决明子能一起泡水吗？这样有什么作用？;浮云的泪5cl;《https://zhidao.baidu.com/question/1796417085301629027.html，浮云的泪5cl》;20140825;网页 *

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