CN111358922A - Traditional Chinese medicine composition for warming and invigorating kidney yang and improving cold constitution and preparation method and application thereof - Google Patents

Traditional Chinese medicine composition for warming and invigorating kidney yang and improving cold constitution and preparation method and application thereof Download PDF

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Publication number
CN111358922A
CN111358922A CN202010123604.0A CN202010123604A CN111358922A CN 111358922 A CN111358922 A CN 111358922A CN 202010123604 A CN202010123604 A CN 202010123604A CN 111358922 A CN111358922 A CN 111358922A
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parts
warming
ginseng
kidney yang
fructus
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李琴
黎倩
李政海
段婷婷
杨波
郭国荣
石勇新
屈美娟
陈焕青
麦瑞芬
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Guangxi Yulin Pharmaceutical Group Co ltd
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Guangxi Yulin Pharmaceutical Group Co ltd
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Abstract

The invention relates to a traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution, a preparation method and application thereof. The active ingredients of the composition are prepared from the following raw materials in parts by weight: 0.5-1.5 parts of ginseng, 0.1-1 part of dried ginger, 0.9-2 parts of rhizoma polygonati, 0.9-2 parts of mulberry, 0.9-2 parts of medlar and 1-3 parts of red date. The traditional Chinese medicine composition and the health-care beverage for warming and invigorating kidney yang and improving cold physique have no toxic or side effect, have remarkable warming and invigorating kidney yang effects, are quick to take effect, have original taste and flavor and rich nutrition, have the effects of nourishing yin and tonifying kidney, replenishing essence, dispelling cold, improving immunity, strengthening body resistance, improving human yang qi, activating blood, removing freckles and beautifying, do not need to add additives, sugar substitutes, pigments, essence and preservatives, and are safe to eat.

Description

Traditional Chinese medicine composition for warming and invigorating kidney yang and improving cold constitution and preparation method and application thereof
Technical Field
The invention relates to the field of health-care food, in particular to a traditional Chinese medicine composition for warming and invigorating kidney yang and improving cold constitution, and a preparation method and application thereof.
Background
The cold character is not left in all diseases. Congealing cold in meridians can cause pain in neck, shoulders, waist and legs and rheumatism and bone pain, and particularly easily causes the phenomena of cold hands and feet, frequent urination, poor blood flow, pale and yellowish face, dysmenorrhea caused by cold in uterus, easy breeding of hysteromyoma and the like of women, so that cold in body becomes a large disease which troubles modern people and seriously affects physical and mental health and life quality of human bodies. In addition, people with chronic diseases are generally internally cold and externally hot, which is reflected in that people are easy to get on fire, especially teeth are painful, lipstick is formed, hairs are white and yellow, halitosis is caused, dermatophytosis is caused, cold is feared in winter, heat is feared in summer, limbs are weak, radiated strength is caused when a fist is not clenched, people feel cachexia is caused, so that the people are so-called yang deficiency in traditional Chinese medicine, the whole people are not active, and the breath is short and the sound is low. However, people only see the condition of external heat, and think that the people need to lower fire and clear heat; actually, exogenous heat is caused by the fact that the cold qi of the internal organs is too heavy, and the heat original qi is forced to the outside, and originally hidden in the kidney, the more abundant the original qi is, the deeper the original qi is, and the firmer the original qi is. The insufficiency of original qi, which is naturally driven by cold, is diffused to the outer layer of the body, i.e. the more the original yang goes.
With the increasing acceleration of modern life rhythm and the stimulation of social competition, the pressure of buying rooms is high, work carelessness and losing bitterness are caused, career and marital incompatibility are not smooth, people are working and working, rush, work is carried out day and night or frequent night life, people severely overdrawing and losing people's yang qi, and bad habits and behaviors such as working for a long time and living in an air-conditioning shady and cool environment and the like consume the human body's yang qi, so that the accumulated time and month can easily cause cold constitution, and the enemies of the 'cold' body, deficiency of vital qi and pathogenic qi inevitably coil up and shade formation (yang transformation, shade formation) to show tumors, canceration, swelling and pain (the vital qi impacts cold qi). Cold qi is the pathogenic qi, may be exogenous pathogenic factors dished on the weak body resistance, or may be over-use of western medicines, such as drip infusion of cold pathogenic qi from the outer layer of the body to the lung and spleen of taiyin, resulting in cough, poor appetite, etc.
The traditional Chinese medicine considers that kidneys store innate and acquired essence and transform the kidney essence into kidney qi, wherein the kidney yang, which is also called yang-yang, true yang and true fire, has the effects of warming, exciting, stimulating, evaporating, sealing and storing the body and restricting yin-cold; those with the actions of moistening, calming, shaping and inhibiting excessive yang-heat are called kidney yin, also called Yuan Yin, Zhen Yin and Zhen shui. Kidney yang can promote metabolism, i.e. the process of qi transformation, promote generation of essence, blood and body fluid and convert them into energy, so as to accelerate the progress of various physiological activities of human body, increase heat production and refresh spirit; kidney yin inhibits or slows down the excessive metabolic process of the human body, so that the energy of essence, blood and body fluids is reduced, the progress of various physiological activities of the human body is slowed down, the heat production is relatively reduced, and qi is gathered to form essence, blood and body fluids, spirit tends to calm the mind and the internal conservation, and the kidney yin and the body fluids regulate and control the functional activities of the viscera of the human body and the metabolic process of the essence, blood and body fluids.
Kidney deficiency is divided into deficiency of kidney yin and kidney yang, and different diagnosis and treatment should be made according to different symptoms. The kidney deficiency is usually caused by long-term accumulation, and should be slowly regulated in daily diet therapy. Symptoms of kidney deficiency in women: 1. weakness, insufficiency of genuine qi, frequent urination, aversion to cold and cold limbs: it is characterized by no irritation to the urinary tract, excessive urine volume and especially at night due to kidney yang deficiency, decline of vital gate fire and weakness of bladder, inability to restrict urine; kidney yang is the root of yang qi of the whole body, and vital activities are all promoted by yang qi, and if kidney yang is insufficient, the body cannot be warmed, and cold feeling can occur. 2. Soreness and pain of the waist and knees, hyposexuality, lassitude, edema of lower limbs, shortness of breath, asthma, loose stool: the traditional Chinese medicine considers that the waist is house of kidney, the kidney deficiency can be reflected as waist soreness and pain, and the waist soreness and pain is characterized by dull pain after fatigue. 3. Irregular menstruation, easy chloasma growth and black eye appearance: traditional Chinese medicine considers that the kidney-qi is abundant to regulate qi and blood, and the function of the thoroughfare vessel and conception vessel is normal to ensure that the menstrual cycle is normally circulated, so that the deficiency of the kidney-qi is an important factor of irregular menstruation, and even the menopause can be brought into position early. Kidney qi is insufficient, and the Hyuna skin cannot be moistened, and butterfly-shaped yellowish, yellowish-brown or pale-black plaques often appear at the cheeks, with clear boundaries. In the theory of traditional Chinese medicine, black represents kidney, and dark circles in eyes indicate kidney deficiency, and not only kidney deficiency, but also kidney deficiency, and many other organs are diseased and can accumulate to the kidney after a long time, so that the kidney is often said to be 'chronic disease and kidney', and black circles in eyes are indicated. 4. And (3) infertility: kidney yang deficiency, inability to control sperm and become pregnant, often accompanied by pale menstrual color, soreness and pain of waist, dizziness, aversion to cold, fatigue and hypodynamia. 5. Osteoporosis: the reason is as follows: kidney governs bones, and osteoporosis is likely to occur due to kidney deficiency, which is especially common in middle-aged and elderly women after menopause. 6. The kidney deficiency of women can easily cause symptoms of deficiency of qi and blood, macula, insomnia, dryness-heat of whole body, difficulty in concentrating attention and the like.
How to treat is to remove cold firstly, remove cold and get original qi back by itself, original qi is compared with dragon, dragon should return to nest as a natural phenomenon of body, and cold removal is used as warm heat. The medicine has the effects of warming and invigorating kidney yang, improving cold constitution, enhancing immunity and preserving health from the perspective of medicine-food homologous traditional Chinese medicine health preservation, and becomes the subject of health preservation and health care at present. At present, a lot of cold dispelling health care product beverages exist in the market, but the existing cold dispelling health care product beverages have poor cold dispelling effect; in addition, the traditional Chinese medicinal materials in the formula have various contents, the preparation process is unscientific, active ingredients for warming and invigorating kidney yang are easy to destroy, and additives such as preservatives, essences, pigments and the like are contained, so that the traditional Chinese medicinal materials are not beneficial to health.
Disclosure of Invention
Based on the above, the invention provides a traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold physique. The traditional Chinese medicine composition selects medicinal and edible traditional Chinese medicinal materials, is scientific in compatibility, reasonable in formula, remarkable in effect of warming and recuperating kidney yang and fast in effect, avoids the defect of 'three toxicity of medicines', does not contain additives such as preservative, essence and pigment, is safe to eat and does not have toxic or side effect.
The technical scheme is as follows:
the active ingredients of the traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution are prepared from the following raw materials in parts by weight:
0.5-1.5 parts of ginseng, 0.1-1 part of dried ginger, 0.9-2 parts of rhizoma polygonati, 0.9-2 parts of mulberry, 0.9-2 parts of medlar and 1-3 parts of red date.
In some embodiments, the active ingredients of the traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution are prepared from the following raw materials in parts by weight:
0.8-1.2 parts of ginseng, 0.2-0.6 part of dried ginger, 1.0-1.6 parts of sealwort, 1.0-1.6 parts of mulberry, 1.0-1.6 parts of medlar and 1.8-2.5 parts of red date.
In some embodiments, the active ingredients of the traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution are prepared from the following raw materials in parts by weight:
0.9 to 1.1 parts of ginseng, 0.3 to 0.5 parts of dried ginger, 1.3 to 1.5 parts of sealwort, 1.2 to 1.5 parts of mulberry, 1.2 to 1.5 parts of medlar and 1.9 to 2.2 parts of red date.
The invention also provides a preparation method of the traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution.
The technical scheme comprises 2 types, as shown in (1) and (2):
(1) a preparation method of a traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution comprises the following steps:
respectively pulverizing the ginseng and the dried ginger to obtain ginseng coarse powder and dried ginger coarse powder; mixing rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, adding water, and wet pulverizing to obtain mixed coarse powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae;
mixing Ginseng radix coarse powder, Zingiberis rhizoma coarse powder and mixed coarse powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, adding water to break cell wall, extracting at room temperature for 2 times, centrifuging, microfiltering, and concentrating by reverse osmosis to obtain water extractive solution.
In one embodiment, the water-adding wall-breaking normal-temperature extraction 2 times comprises:
under the condition that the temperature is less than or equal to 30 ℃, water with the weight of 15-20 times of that of the medicinal powder is added for the first time, and water with the weight of 10-15 times of that of the medicinal powder is added for the second time.
(2) A preparation method of a traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution comprises the following steps:
respectively pulverizing the ginseng and the dried ginger to obtain ginseng coarse powder and dried ginger coarse powder; mixing rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, adding water, and wet pulverizing to obtain mixed coarse powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae;
soaking or percolating the ginseng coarse powder and the dried ginger coarse powder with 70% ethanol, and recovering ethanol to obtain ginseng and dried ginger ethanol extract;
mixing the residue powder after alcohol extraction of Ginseng radix and Zingiberis rhizoma with mixed crude powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, adding water to break cell wall, extracting at room temperature for 2 times, centrifuging, microfiltering, and concentrating by reverse osmosis to obtain water extract, and mixing with alcohol extract of Ginseng radix and Zingiberis rhizoma to obtain mixed extract.
The invention also provides application of the traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution.
The technical scheme is as follows:
the traditional Chinese medicine composition is applied to preparing the health-care drink for warming and invigorating kidney yang and improving cold constitution, and the dosage forms of the health-care drink comprise liquid dosage forms and solid dosage forms.
The invention also provides a health drink for warming and recuperating kidney yang and improving cold constitution.
The technical scheme is as follows:
a health beverage for warming and recuperating kidney yang and improving cold constitution is prepared from the raw materials including the Chinese medicinal composition and acceptable auxiliary materials in the health beverage; the acceptable auxiliary materials in the health-care beverage are selected from one or a combination of more of water, honey, maltodextrin and Arabic gum.
In some embodiments, the traditional Chinese medicine composition extract accounts for 10-60% of the raw materials for preparing the health-care beverage by mass percent.
In some of these embodiments, the liquid dosage form: containing ginsenoside Rg1(C42H72O14) Ginsenoside Re (C)48H82O18) Ginsenoside Rb1(C54H92O23) The total amount should not be less than 30. mu.g/g.
Solid dosage form: containing ginsenoside Rg1(C42H72O14) Ginsenoside Re (C)48H82O18) Ginsenoside Rb1(C54H92O23) The total amount should not be less than 300. mu.g/g.
The traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution, and the preparation method and the application thereof have the following advantages and beneficial effects:
the invention designs a formula aiming at warming and invigorating kidney yang and improving cold physique, and selects nourishing medicinal and edible traditional Chinese medicinal materials: ginseng (artificially planted), rhizoma polygonati, dried ginger, red date and mulberry are used as raw materials, wherein: ginseng is the monarch drug for invigorating primordial qi, restoring pulse, relieving depletion, invigorating spleen, benefiting lung, promoting fluid production, nourishing blood, tranquilizing mind, improving intelligence, and tonifying the upper part; the dried ginger is pungent and hot and has the effects of warming the middle-jiao to dispel cold, restoring yang to dredge vessels, warming and invigorating kidney yang and improving yang qi of a human body as a ministerial drug; rhizoma polygonati, medlar and mulberry are used as adjuvants to nourish yin, tonify kidney and replenish essence, promote the production of body fluid, moisten dryness and tonify the lower part of the body fluid, and the yang tonics are supported by the yin tonics, namely the effects of 'hardness and softness are mutually complemented' and 'yin and yang tonics' are achieved; the red dates have the effects of nourishing blood, soothing nerves and relieving drug properties, all the ingredients are used together to achieve the effect of warming and invigorating kidney yang and improving cold physique, and long-term drinking can promote qi and blood exuberance, make the face ruddy and improve cold body symptoms of hands and feet.
The traditional Chinese medicine composition provided by the invention selects traditional Chinese medicinal materials with homology of medicine and food, is scientific in compatibility and reasonable in formula, avoids the defect of 'three-toxin of medicine', is safe to eat, has no toxic or side effect, and has remarkable effects of warming and invigorating kidney yang and quick response.
Meanwhile, the health-care beverage has the natural fragrance and taste of the ginseng, the ginger, the red date and the sealwort, does not need to be added with additives, sugar substitutes, pigments, essence, preservatives and the like, has original taste and rich nutrition, and has the effects of warming and invigorating kidney yang, improving human body yang, strengthening body resistance and consolidating constitution, improving immunity, dispelling cold, accelerating blood circulation, removing freckles and beautifying. Can be used for improving cold constitution symptoms caused by kidney yang deficiency, such as nocturia, aversion to cold, cold limbs, soreness of waist and knees, sexual hypofunction, listlessness, short breath and asthma.
In addition, the preparation method of the traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution is simple and easy to control, and is suitable for large-scale production.
Detailed Description
The present invention will be described in further detail with reference to specific examples. The present invention may be embodied in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
The invention provides a traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution, which comprises the following active ingredients in parts by weight:
0.5-1.5 parts of ginseng, 0.1-1 part of dried ginger, 0.9-2 parts of rhizoma polygonati, 0.9-2 parts of mulberry, 0.9-2 parts of medlar and 1-3 parts of red date.
The traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold physique provided by the invention has the following main components:
ginseng: (Panax ginseng C.A.Mey) is a top quality known from ancient times as "the king of various herbs", "nourishing yin and tonifying, strengthening body resistance and consolidating constitution", and contains various saponins and polysaccharide components, and has the following properties and tastes: sweet and slightly bitter in taste, warm and mild in nature. It enters spleen, lung and heart meridians. Tonify qi, secure collapse, promote fluid production, induce tranquilization, and promote intelligence. The succulent root of ginseng is a well-known tonic, is suitable for regulating blood pressure, recovering heart function, neurasthenia and asthenia, and also has expectorant, stomach invigorating, diuretic and exciting effects. The main indications are body deficiency and desire to loose, cold limbs and a little pulse, spleen deficiency and poor appetite, lung deficiency and cough, body fluid deficiency and thirst, internal heat and diabetes, deficiency of qi and blood, deficiency of deficiency and asthenia caused by chronic diseases, palpitation and insomnia, impotence and cold womb; heart failure, cardiogenic shock. Can be used for treating short breath, dyspnea, palpitation, amnesia, thirst, hyperhidrosis, anorexia, asthenia, acute and chronic diseases, and shock and collapse caused by blood loss. Tonify primordial qi, relieve depletion and promote fluid production, induce tranquilization. It is indicated for deficiency due to overstrain, poor appetite, lassitude, regurgitation, diarrhea, cough, dyspnea, spontaneous sweating, palpitation, amnesia, vertigo, headache, impotence, frequent micturition, diabetes, metrorrhagia, metrostaxis, chronic infantile convulsion, and deficiency of both qi and blood.
Ginseng has an excitatory effect on the central nervous system, whereas in large quantities it has an inhibitory effect. Can enhance the excitation and inhibition process of the higher nerve activity of animals. It can also enhance the adaptability of organism to nonspecific stimulation, reduce fatigue, and regulate the balance of excitation process and inhibition process of central nervous system. The results of the research on the influence of the ginseng on the brain electrical activity of the animal show that: it has effects on both excitatory and inhibitory neural processes, but primarily enhances the excitatory processes of the cerebral cortex. By acting simultaneously on the inhibition process, the inhibition tends to be concentrated, resulting in accelerated and more complete differentiation. Ginseng radix has effects of regulating nerve function, and recovering nervous process caused by disorder due to stress. Ginsenoside Rb has central tranquilizing effect1、Rb2Rc mixed saponin has stabilizing effect; rg has central excitation. The effects of ginsenoside on the center are small dose excitation and large dose inhibition.
Ginseng can improve the oxygen uptake capacity of the brain, and also has obvious influence on the blood flow volume and the energy metabolism of the brain. The ginseng preparation can increase the glucose uptake of rabbit brain, reduce the ratio of lactic acid, pyruvic acid and lactic acid/pyruvic acid, and change the glucose utilization from anaerobic metabolism to aerobic metabolism. Ginseng also increases the amount of free inorganic phosphorus in the cerebral cortex by 25%. The ginsenoside can improve brain oxygen uptake. The total saponins of Ginseng radix and Ginseng radix have protective effect on cerebral ischemia/reperfusion injury. In a word, ginseng can make the animal brain more reasonably utilize the energy substance glucose, oxidize the energy and synthesize more ATP for activities such as learning and memory.
Human body experiments prove that the mechanism of the fatigue resistance of the ginseng is probably related to the increase of blood fat and the promotion of protein and RNA synthesis. Research shows that ginsenoside Rg1Has remarkable antifatigue effect, and contains neutral saponin (Rb)1、Rb2Rc, etc.) have no anti-fatigue effect. The lipophilic component remained after separating ginsenoside can also increase spontaneous movement of mouse, and has antifatigue effect. Ginseng radix has the advantages of economic availability of glycogen and high energy phosphate, preventing accumulation of lactic acid and pyruvic acid, and promoting metabolism. Ginseng also prevents depletion of glycogen and cholesterol in adrenal glands in tissues caused by long-term exercise in rats.
Dried ginger: the product is dried rhizome of Zingiber officinale Rosc of Zingiberaceae. Pungent and hot. It enters spleen, stomach, kidney, heart and lung meridians. Has the functions of warming spleen and stomach for dispelling cold, restoring yang and promoting blood circulation, and warming lung and resolving fluid retention.
Rhizoma polygonati: the product is dried rhizome of Polygonatum sibiricum Red (Polygonatum sibiricum Red.) belonging to Liliaceae. Sweet and mild in nature and taste. It has effects in invigorating qi, nourishing yin, invigorating spleen, moistening lung, invigorating kidney, and promoting fluid production, and can be used for treating deficiency of spleen-stomach qi, asthenia, stomach yin deficiency, xerostomia, anorexia, lung deficiency, cough, pulmonary tuberculosis, hemoptysis, essence and blood deficiency, soreness of waist and knees, premature gray hair, and internal heat. Can tonify deficiency, stop cold and heat, and fill essence, and is the best choice for tonifying yellow uterus because polygonatum is subjected to pure qi of Wu Yi. When earth is good at mother's of all things and mother's nourishes, water and fire are both harmed and wood and alloy are combined, all pathogens are removed, and all diseases are not born . In the formula of Yun, rhizoma Polygonati can strengthen the middle-jiao and replenish qi, so as to improve the five internal organs, strengthen the muscles, strengthen the bone marrow, increase the strength, make people not old for many years, make the teeth white and black, and make the teeth more normal. The fleshy rootstock is fat and thick, contains a large amount of starch, sugar, fat, protein, carotene, vitamins and various other nutritional ingredients, can allay hunger when eaten raw or stewed, has the function of body building, can multiply the vitality of people, has abundant muscles and strong bone marrow, and is very beneficial to the body.
Mulberry: the product is dried fruit cluster of Morus alba L of Moraceae. And (4) harvesting the fruits after turning red for 4-6 months, and drying in the sun or drying in the sun after slightly steaming. Mulberry fruit has the functions of nourishing yin, enriching blood, promoting the production of body fluid and moistening dryness. Can be used for treating liver and kidney yin deficiency, giddiness tinnitus, cardiopalmus insomnia, early white beard and hair, body fluid consumption thirst, internal heat diabetes, blood deficiency and intestinal dryness constipation. Mulberry contains abundant active protein, provitamin A, B1, B2, PP and C, amino acid, malic acid, succinic acid, tartaric acid, carotene, mineral calcium, phosphorus, iron, copper, zinc and other components, the nutrition of the mulberry is 5-6 times that of apple and 4 times that of grape, and the mulberry has multiple efficacies and is known as the best health-care fruit product in twenty-first century by the medical community. The mulberry can obviously improve the immunity of human bodies and has the effects of delaying senility, maintaining beauty and keeping young after being eaten frequently.
Medlar: the product is dried mature fruit of Lycium barbarum L of Solanaceae. The medlar has the functions of tonifying kidney and nourishing liver, replenishing vital essence and improving eyesight, strengthening bones and muscles, removing lumbago and prolonging life after being taken for a long time. Especially for middle-aged women with kidney deficiency, it is most suitable for eating. Chinese materia Medica: medlar, nourishing liver, nourishing kidney, and tonifying lung. It can be used for treating deficiency of liver and kidney, dizziness, blurred vision, soreness of waist and knees, sexual impotence, premature ejaculation, cough due to asthenia, diabetes, and polydipsia. It is the essential herb for liver and kidney deficiency because it excels in nourishing yin, replenishing vital essence and nourishing blood. The compendium of materia Medica records: medlar, tonifying kidney and producing sperm, nourishing liver and improving eyesight, strengthening essence and bones, removing fatigue, changing color easily, whitening, improving eyesight and calming the nerves, and prolonging life. Wolfberry fruit has the functions of nourishing liver and kidney, benefiting vital essence and improving eyesight. Can be used for treating asthenia, soreness of waist and knees, vertigo, tinnitus, internal heat, diabetes, blood deficiency, sallow complexion, and blurred vision. Wolfberry fruit is rich in: wolfberry polysaccharide, monosaccharide, betaine, fatty acid, protein and polypeptide, vitamin B1, vitamin B2, vitamin C, 18 amino acids (containing 8 essential amino acids), microelements (calcium, zinc, selenium, magnesium, iron, manganese, phosphorus and the like), carotene (obviously higher than fruits and vegetables), vitamin E, vitamin D, phospholipid and the like. Pharmacological research proves that the medlar can regulate the immunologic function of organisms, can effectively inhibit tumor growth and cell mutation, and has the effects of delaying senility, resisting fatty liver, regulating blood fat, blood sugar and the like.
Red dates: is dried mature fruit of Ziziphus jujuba Mill of Rhamnaceae. Collected in autumn when the fruit is ripe, dried by airing, sunning or baking, and the fruit peel is red to mauve. The red date has the effects of tonifying middle-jiao and Qi, nourishing blood and soothing nerves and moderating the property of the medicine, and is used for treating spleen deficiency, anorexia, weakness, loose stool and hysteria of women; chinese materia Medica: tonify spleen and stomach, replenish qi and blood, calm heart and spirit, regulate ying and wei and harmonize property of herbs. Mainly treats weakness of the spleen and the stomach, deficiency of qi and blood, poor appetite, loose stool, fatigue, weakness, palpitation, insomnia, dryness of the viscera of women and disharmony between nutrient and defensive systems. The red dates are Sheng products for nourishing yin, tonifying yang, benefiting qi and nourishing blood, and can achieve the effects of health preservation and health care by being taken well. The modern pharmacology finds that the red dates contain rich nutritional ingredients such as proteins, fats, saccharides, organic acids, vitamin A, vitamin C, trace calcium and various amino acids, the traditional Chinese medicine considers that the red dates are warm in nature, nourish blood and protect blood and can improve blood circulation, and the pharmacology researches find that the red dates contain rich vitamins, fructose and various amino acids, and certain ingredients can increase the content of red blood cells in blood, enhance the bone marrow orientation function and make the face ruddy.
The invention designs a formula aiming at warming and invigorating kidney yang and improving cold physique, and selects nourishing medicinal and edible medicinal materials: ginseng (artificially planted), rhizoma polygonati, dried ginger, red date and mulberry are used as raw materials, wherein: ginseng is the monarch drug for invigorating primordial qi, restoring pulse, relieving depletion, invigorating spleen, benefiting lung, promoting fluid production, nourishing blood, tranquilizing mind, improving intelligence, and tonifying the upper part; the dried ginger is pungent and hot and has the effects of warming the middle-jiao to dispel cold, restoring yang to dredge vessels, warming and invigorating kidney yang and improving yang qi of a human body as a ministerial drug; rhizoma polygonati, medlar and mulberry are used as adjuvants to nourish yin, tonify kidney and replenish essence, promote the production of body fluid, moisten dryness and tonify the lower part of the body fluid, and the yang tonics are supported by the yin tonics, namely the effects of 'hardness and softness are mutually complemented' and 'yin and yang tonics' are achieved; the red dates have the effects of nourishing blood, soothing nerves and relieving drug properties, all the ingredients are used together to achieve the effect of warming and invigorating kidney yang and improving cold physique, and long-term drinking can promote qi and blood exuberance, make the face ruddy and improve cold body symptoms of hands and feet.
The traditional Chinese medicine composition provided by the invention selects materials with homology of medicine and food, is scientific in compatibility and reasonable in formula, avoids the defect of 'three-component toxicity of medicine', is safe to eat, has no toxic or side effect, and has remarkable effects of warming and invigorating kidney yang and quick response.
In some preferred embodiments, the active ingredients of the traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution are prepared from the following raw materials in parts by weight:
0.8-1.2 parts of ginseng, 0.2-0.6 part of dried ginger, 1.0-1.6 parts of sealwort, 1.0-1.6 parts of mulberry, 1.0-1.6 parts of medlar and 1.8-2.5 parts of red date.
In some more preferred embodiments, the active ingredients of the traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution are prepared from the following raw materials in parts by weight:
0.9 to 1.1 parts of ginseng, 0.3 to 0.5 parts of dried ginger, 1.3 to 1.5 parts of sealwort, 1.2 to 1.5 parts of mulberry, 1.2 to 1.5 parts of medlar and 1.9 to 2.2 parts of red date.
The invention also provides a preparation method of the traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution.
The technical scheme comprises 2 types, as shown in (1) and (2):
(1) a preparation method of a traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution comprises the following steps:
respectively pulverizing the ginseng and the dried ginger to obtain ginseng coarse powder and dried ginger coarse powder; mixing rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, adding water, and wet pulverizing to obtain mixed coarse powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae;
mixing Ginseng radix coarse powder, Zingiberis rhizoma coarse powder and mixed coarse powder slurry of 4 kinds of medicinal materials including rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, adding water to break cell wall, extracting at room temperature for 2 times, centrifuging, ultra-micro filtering, and concentrating by reverse osmosis to obtain water extractive solution.
Specifically, the preparation method of the traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution comprises the following steps:
respectively pulverizing the ginseng, the dried ginger, the sealwort, the mulberry, the medlar and the red date; 4 medicinal materials of rhizoma polygonati, mulberry, medlar and red date are mixed and added with water for wet grinding treatment; obtaining mixed coarse powder slurry of ginseng coarse powder, dried ginger coarse powder and 4 medicinal materials of rhizoma polygonati, mulberry, medlar and red date;
mixing the coarse powder of Ginseng radix and Zingiberis rhizoma with mixed coarse powder slurry of 4 kinds of medicinal materials including rhizoma Polygonati, Mori fructus, fructus Lycii, and fructus Jujubae, and performing wall-breaking normal temperature water extraction for 2 times; the method specifically comprises the following steps: under the condition that the temperature is less than or equal to 30 ℃, water extraction with the weight of 15-20 times of that of the medicinal powder is added for the first time, and water extraction with the weight of 10-15 times of that of the medicinal powder is added for the second time to obtain a water extraction solution. Then the concentrated solution with the solid content of 10 percent to 20 percent is obtained by centrifugation (the rotating speed is 1500r/min to 15000r/min), microfiltration (the aperture of a filter membrane is 500nm) and reverse osmosis concentration treatment.
(2) A preparation method of a traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution comprises the following steps:
respectively pulverizing the ginseng and the dried ginger to obtain ginseng coarse powder and dried ginger coarse powder; 4 kinds of rhizoma polygonati, mulberry, medlar and red date are mixed, water is added for wet grinding treatment, and mixed coarse powder slurry of 4 kinds of rhizoma polygonati, mulberry, medlar and red date is obtained;
soaking or percolating the ginseng coarse powder and the dried ginger coarse powder with 70% ethanol, mixing the residue powder of the ginseng and the dried ginger after ethanol extraction with mixed coarse powder slurry of rhizoma polygonati, mulberry, medlar and red date, adding water to break the wall and extracting for 2 times at normal temperature, centrifuging, microfiltering, performing reverse osmosis concentration treatment to obtain water extract, and mixing the water extract with the alcohol extract of the ginseng and the dried ginger.
Specifically, the preparation method of the traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution comprises the following steps:
respectively pulverizing the ginseng and the dried ginger to obtain ginseng coarse powder and dried ginger coarse powder; mixing rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, adding water, and wet pulverizing to obtain mixed coarse powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae;
respectively soaking or percolating the ginseng coarse powder and the dried ginger coarse powder with 70% ethanol (at a temperature of less than 30 ℃), and recovering ethanol to obtain ginseng and dried ginger ethanol extracts;
mixing the residue powder after alcohol extraction of Ginseng radix and Zingiberis rhizoma with mixed coarse powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, and performing wall-breaking normal temperature water extraction for 2 times; the method specifically comprises the following steps: under the condition that the temperature is less than or equal to 30 ℃, water extraction with the weight of 15-20 times of that of the medicinal powder is added for the first time, and water extraction with the weight of 10-15 times of that of the medicinal powder is added for the second time to obtain a water extraction solution. Centrifuging (rotation speed is 1500 r/min-15000 r/min), microfiltering (filter membrane aperture is 500nm), reverse osmosis concentrating to obtain water extract, and mixing with the above alcohol extract of Ginseng radix and Zingiberis rhizoma.
In some preferred embodiments, the method further comprises the following steps: and placing the filtered reverse osmosis concentrated extract, the ginseng extract and the dried ginger alcohol extract into a vacuum concentrator, setting the vacuum degree to be 0.08-0.1 MPa and the temperature to be 60-70 ℃ to obtain a concentrated solution with the solid content of 10-20%.
The preparation method of the traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution adopts low-temperature (less than 30 ℃) extraction to ensure that active ingredients are not damaged.
The invention also provides application of the traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution.
The technical scheme is as follows:
the traditional Chinese medicine composition is applied to preparing the health-care drink for warming and invigorating kidney yang and improving cold constitution, and the dosage forms of the health-care drink comprise liquid dosage forms and solid dosage forms.
The invention also provides a health drink for warming and recuperating kidney yang and improving cold constitution.
The technical scheme is as follows:
a health beverage for warming and recuperating kidney yang and improving cold constitution is prepared from the raw materials including the Chinese medicinal composition and acceptable auxiliary materials in the health beverage; the acceptable auxiliary materials in the health-care beverage are selected from one or a combination of more of water, honey, maltodextrin and Arabic gum.
The health-care beverage has the natural fragrance and taste of the ginseng, the ginger, the red date and the sealwort, is not added with any additive, sugar substitute, pigment, essence, preservative and the like, has original taste and rich nutrition, and has the effects of nourishing yin, tonifying kidney, replenishing essence, dispelling cold, improving immunity, strengthening body resistance, consolidating constitution, improving human yang, activating blood, removing freckles and beautifying.
In some preferred embodiments, the traditional Chinese medicine composition accounts for 10-60% of the raw materials for preparing the health-care beverage by mass percent.
The invention also provides a preparation method of the health drink for warming and recuperating kidney yang and improving cold constitution.
The first technical scheme is as follows:
the preparation method of the health drink for warming and recuperating kidney yang and improving cold constitution comprises the following steps:
(1) respectively pulverizing the ginseng and the dried ginger to obtain ginseng coarse powder and dried ginger coarse powder; mixing rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, adding water, and wet pulverizing to obtain mixed coarse powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae;
(2) mixing the coarse powder of Ginseng radix and Zingiberis rhizoma with mixed coarse powder slurry of 4 kinds of medicinal materials including rhizoma Polygonati, Mori fructus, fructus Lycii, and fructus Jujubae, performing wall-breaking and water-heating extraction for 2 times to obtain water extract, centrifuging, and microfiltering;
(3) adding auxiliary materials acceptable for health-care drinks into the water extract, adding water to a constant volume, and uniformly mixing.
In some preferred embodiments, the acceptable auxiliary materials in the health-care beverage are selected from water and honey (or not added with honey), wherein the weight part of the honey is 0-100 parts.
The step (3) comprises the following steps:
weighing honey (or not adding honey) according to the preparation amount, adding a proper amount of drinking water, heating and stirring to dissolve, adding into a preparation tank, and stirring and mixing with the water extract obtained in the step (2) to obtain a preparation solution;
adding water into the prepared solution to adjust the total amount to 900-1100 parts, preferably 1000 parts, filtering, sterilizing, subpackaging, encapsulating and packaging to obtain the liquid health-care beverage for warming and recuperating kidney yang and improving cold constitution.
The second technical scheme is as follows:
the preparation method of the health drink for warming and recuperating kidney yang and improving cold constitution comprises the following steps:
(1) respectively pulverizing the ginseng and the dried ginger to obtain ginseng coarse powder and dried ginger coarse powder; mixing rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, adding water, and wet pulverizing to obtain mixed coarse powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae;
(2) respectively soaking or percolating the ginseng coarse powder and the dried ginger coarse powder with 70% ethanol (at a temperature of less than 30 ℃), and recovering ethanol to obtain ginseng and dried ginger ethanol extracts;
(3) mixing the residue powder after alcohol extraction of Ginseng radix and Zingiberis rhizoma with mixed coarse powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, performing wall-breaking normal temperature water extraction for 2 times, specifically: under the condition that the temperature is less than or equal to 30 ℃, water extraction with the weight of 15-20 times of that of the medicinal powder is added for the first time, and water extraction with the weight of 10-15 times of that of the medicinal powder is added for the second time to obtain a water extraction solution. Centrifuging (the rotating speed is 1500 r/min-15000 r/min), micro-filtering (the aperture of a filter membrane is 500nm), and performing reverse osmosis concentration treatment to obtain a concentrated solution;
(4) and (3) placing the concentrated solution obtained by the reverse osmosis concentration treatment, the ginseng alcohol extract and the dried ginger alcohol extract in a vacuum concentrator, setting the vacuum degree to be 0.08 MPa-0.1 MPa and the temperature to be 60-70 ℃ to obtain the concentrated solution with the solid content of 10-20%.
(5) And adding auxiliary materials acceptable for the health-care beverage into the concentrated solution, uniformly mixing, performing spray drying, performing spray granulation, subpackaging and packaging to obtain the solid health-care beverage.
In some preferred embodiments, the acceptable adjuvant in the health beverage is at least one selected from water, honey (or no honey), maltodextrin and acacia gum. Wherein the honey accounts for 0-100 parts by weight, and the maltodextrin and the Arabic gum serve as excipients.
In some preferred embodiments, the step (4) comprises the steps of:
mixing the concentrated solution with Mel (or not) and 50% excipient (maltodextrin or acacia), and spray drying to obtain powder;
and then performing spray granulation on the powder by using 10% powder slurry, drying, subpackaging, printing, boxing and boxing to obtain the solid health-care drink for warming and invigorating kidney yang and improving cold constitution.
The solid health drink for warming and recuperating kidney yang and improving cold constitution, which is prepared by the invention, has the specification: finely concentrated, wherein the net content of solid particles: 3g of the total weight. Is convenient to carry, can be carried by office workers or travelers, and can be drunk after being brewed.
The following embodiments are provided to describe the traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold physique, the health drink and the preparation method thereof in more detail.
Example 1
The embodiment provides a health-care beverage for warming and recuperating kidney yang and improving cold constitution and a preparation method thereof.
The health-care beverage for tonifying kidney yang and improving cold physique at moderate temperature is prepared from the following raw materials in parts by weight:
0.5 part of ginseng, 0.6 part of dried ginger, 0.9 part of sealwort, 1.0 part of mulberry, 2 parts of medlar, 2.8 parts of red date, 40 parts of honey and water till 1000 parts.
The preparation method comprises the following steps:
(1) respectively pulverizing the ginseng and the dried ginger in parts by weight to obtain ginseng coarse powder and dried ginger coarse powder; mixing rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, adding water, and wet pulverizing to obtain mixed crude powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae;
(2) mixing the coarse powder of Ginseng radix and Zingiberis rhizoma with the mixed coarse powder slurry of 4 kinds of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, and performing wall-breaking extraction with normal temperature water for 2 times; the method specifically comprises the following steps: under the condition that the temperature is less than or equal to 30 ℃, water extraction with the weight of 15-20 times of that of the medicinal powder is added for the first time, and water extraction with the weight of 10-15 times of that of the medicinal powder is added for the second time to obtain a water extraction solution. Then centrifugating (the rotating speed is 1500 r/min-15000 r/min), microfiltering (the aperture of a filter membrane is 500nm), carrying out reverse osmosis concentration treatment to obtain a concentrated solution with the solid content of 10-20%, and transferring the concentrated solution into a preparation tank.
(3) Weighing honey according to the preparation amount, adding a proper amount of drinking water, heating and stirring to dissolve, adding into a preparation tank, and stirring and mixing with the water extraction concentrated solution in the step (2) to obtain a preparation solution;
adding water into the prepared liquid to adjust the total amount to 1000 parts, filtering, sterilizing, filling and packaging to obtain the liquid health-care drink for warming and recuperating kidney yang and improving cold constitution.
Example 2
The embodiment provides a health-care beverage for warming and recuperating kidney yang and improving cold constitution and a preparation method thereof.
The health-care beverage for tonifying kidney yang and improving cold physique at moderate temperature is prepared from the following raw materials in parts by weight:
0.8 part of ginseng, 0.2 part of dried ginger, 1.2 parts of sealwort, 1.1 parts of mulberry, 1.2 parts of medlar, 1.8 parts of red date, 60 parts of honey and water till 1000 parts.
The preparation method comprises the following steps:
(1) respectively pulverizing the ginseng and the dried ginger in parts by weight to obtain ginseng coarse powder and dried ginger coarse powder; mixing rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, adding water, and wet pulverizing to obtain mixed crude powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae;
(2) mixing the coarse powder of Ginseng radix and Zingiberis rhizoma with the mixed coarse powder slurry of 4 kinds of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, and performing wall-breaking extraction with normal temperature water for 2 times; the method specifically comprises the following steps: under the condition that the temperature is less than or equal to 30 ℃, water extraction with the weight of 15-20 times of that of the medicinal powder is added for the first time, and water extraction with the weight of 10-15 times of that of the medicinal powder is added for the second time to obtain a water extraction solution. Then centrifugating (the rotating speed is 1500 r/min-15000 r/min), microfiltering (the aperture of a filter membrane is 500nm), carrying out reverse osmosis concentration treatment to obtain a concentrated solution with the solid content of 10-20%, and transferring the concentrated solution into a preparation tank.
(3) Weighing honey according to the preparation amount, adding a proper amount of drinking water, heating and stirring to dissolve, adding into a preparation tank, and stirring and mixing with the water extraction concentrated solution in the step (2) to obtain a preparation solution;
adding water into the prepared liquid to adjust the total amount to 1000 parts, filtering, sterilizing, filling and packaging to obtain the liquid health-care drink for warming and recuperating kidney yang and improving cold constitution.
Example 3
The embodiment provides a health-care beverage for warming and recuperating kidney yang and improving cold constitution and a preparation method thereof.
The health-care beverage for tonifying kidney yang and improving cold physique at moderate temperature is prepared from the following raw materials in parts by weight:
0.9 portion of ginseng, 0.3 portion of dried ginger, 1.3 portions of rhizoma polygonati, 1.2 portions of mulberry, 1.2 portions of medlar, 1.9 portions of red date, 70 portions of honey and water to 1000 portions.
The preparation method comprises the following steps:
(1) respectively pulverizing the ginseng and the dried ginger in parts by weight to obtain ginseng coarse powder and dried ginger coarse powder; mixing rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, adding water, and wet pulverizing to obtain mixed crude powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae;
(2) mixing the coarse powder of Ginseng radix and Zingiberis rhizoma with the mixed coarse powder slurry of 4 kinds of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, and performing wall-breaking extraction with normal temperature water for 2 times; the method specifically comprises the following steps: under the condition that the temperature is less than or equal to 30 ℃, water extraction with the weight of 15-20 times of that of the medicinal powder is added for the first time, and water extraction with the weight of 10-15 times of that of the medicinal powder is added for the second time to obtain a water extraction solution. Then centrifugating (the rotating speed is 1500 r/min-15000 r/min), microfiltering (the aperture of a filter membrane is 500nm), carrying out reverse osmosis concentration treatment to obtain a concentrated solution with the solid content of 10-20%, and transferring the concentrated solution into a preparation tank.
(3) Weighing honey according to the preparation amount, adding a proper amount of drinking water, heating and stirring to dissolve, adding into a preparation tank, and stirring and mixing with the water extraction concentrated solution in the step (2) to obtain a preparation solution;
adding water into the prepared liquid to adjust the total amount to 1000 parts, filtering, sterilizing, filling and packaging to obtain the liquid health-care drink for warming and recuperating kidney yang and improving cold constitution.
Example 4
The embodiment provides a health-care beverage for warming and recuperating kidney yang and improving cold constitution and a preparation method thereof.
The health-care beverage for tonifying kidney yang and improving cold physique at moderate temperature is prepared from the following raw materials in parts by weight:
1.0 part of ginseng, 0.4 part of dried ginger, 1.4 parts of sealwort, 1.4 parts of mulberry, 1.4 parts of medlar, 2.0 parts of red date and 90 parts of honey, and water is added to the mixture to reach 1000 parts.
The preparation method comprises the following steps:
(1) respectively pulverizing the ginseng and the dried ginger in parts by weight to obtain ginseng coarse powder and dried ginger coarse powder; mixing rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, adding water, and wet pulverizing to obtain mixed crude powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae;
(2) mixing the coarse powder of Ginseng radix and Zingiberis rhizoma with the mixed coarse powder slurry of 4 kinds of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, and performing wall-breaking extraction with normal temperature water for 2 times; the method specifically comprises the following steps: under the condition that the temperature is less than or equal to 30 ℃, water extraction with the weight of 15-20 times of that of the medicinal powder is added for the first time, and water extraction with the weight of 10-15 times of that of the medicinal powder is added for the second time to obtain a water extraction solution. Then centrifugating (the rotating speed is 1500 r/min-15000 r/min), microfiltering (the aperture of a filter membrane is 500nm), carrying out reverse osmosis concentration treatment to obtain a concentrated solution with the solid content of 10-20%, and transferring the concentrated solution into a preparation tank.
(3) Weighing honey according to the preparation amount, adding a proper amount of drinking water, heating and stirring to dissolve, adding into a preparation tank, and stirring and mixing with the water extraction concentrated solution in the step (2) to obtain a preparation solution;
adding water into the prepared liquid to adjust the total amount to 1000 parts, filtering, sterilizing, filling and packaging to obtain the liquid health-care drink for warming and recuperating kidney yang and improving cold constitution.
Example 5
The embodiment provides a health-care beverage for warming and recuperating kidney yang and improving cold constitution and a preparation method thereof.
The health-care beverage for tonifying kidney yang and improving cold physique at moderate temperature is prepared from the following raw materials in parts by weight:
1.0 part of ginseng, 0.4 part of dried ginger, 1.4 parts of sealwort, 1.4 parts of mulberry, 1.4 parts of medlar, 2.0 parts of red date and maltodextrin with the net content of 50 percent.
The preparation method comprises the following steps:
(1) respectively pulverizing the ginseng and the dried ginger to obtain ginseng coarse powder and dried ginger coarse powder; mixing rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, adding water, and wet pulverizing to obtain mixed coarse powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae;
(2) respectively soaking or percolating the ginseng coarse powder and the dried ginger coarse powder with 70% ethanol (at a temperature of less than 30 ℃), and recovering ethanol to obtain ginseng and dried ginger ethanol extracts;
(3) mixing the residue powder after alcohol extraction of Ginseng radix and Zingiberis rhizoma with mixed coarse powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, performing wall-breaking normal temperature water extraction for 2 times, specifically: under the condition that the temperature is less than or equal to 30 ℃, water extraction with the weight of 15-20 times of that of the medicinal powder is added for the first time, and water extraction with the weight of 10-15 times of that of the medicinal powder is added for the second time to obtain a water extraction solution. Centrifuging (the rotating speed is 1500 r/min-15000 r/min), micro-filtering (the aperture of a filter membrane is 500nm), and performing reverse osmosis concentration treatment to obtain a concentrated solution;
(4) and putting the concentrated solution obtained by the reverse osmosis concentration treatment, the ginseng alcohol extract and the dried ginger alcohol extract into a vacuum concentrator, setting the vacuum degree to be 0.08 MPa-0.1 MPa and the temperature to be 60-70 ℃ to obtain the concentrated solution with the solid content of 10-20 percent.
(5) And adding maltodextrin with the net content of 50% into the concentrated solution, uniformly mixing, performing spray drying, performing spray granulation, subpackaging and packaging to obtain the solid health-care beverage.
Example 6
The embodiment provides a health-care beverage for warming and recuperating kidney yang and improving cold constitution and a preparation method thereof.
The health-care beverage for tonifying kidney yang and improving cold physique at moderate temperature is prepared from the following raw materials in parts by weight:
1.0 part of ginseng, 0.4 part of dried ginger, 1.4 parts of sealwort, 1.4 parts of mulberry, 1.4 parts of medlar, 2.0 parts of red date and acacia with the net content of 50%.
The preparation method comprises the following steps:
(1) respectively pulverizing the ginseng and the dried ginger to obtain ginseng coarse powder and dried ginger coarse powder; mixing rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, adding water, and wet pulverizing to obtain mixed coarse powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae;
(2) respectively soaking or percolating the ginseng coarse powder and the dried ginger coarse powder with 70% ethanol (at a temperature of less than 30 ℃), and recovering ethanol to obtain ginseng and dried ginger ethanol extracts;
(3) mixing the residue powder after alcohol extraction of Ginseng radix and Zingiberis rhizoma with mixed coarse powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, performing wall-breaking normal temperature water extraction for 2 times to obtain water extract, microfiltering, and performing reverse osmosis concentration treatment to obtain concentrated solution;
(4) and adding the alcohol extract of the ginseng and the dried ginger into the concentrated solution obtained by the reverse osmosis concentration treatment, placing the concentrated solution into a vacuum concentrator, and setting the vacuum degree to be 0.08MPa to 0.1MPa and the temperature to be 60 ℃ to 70 ℃ to obtain the concentrated solution with the solid content of 10 percent to 20 percent.
(5) And adding Arabic gum with a net content of 50% into the concentrated solution, uniformly mixing, performing spray drying, performing spray granulation, subpackaging, and packaging to obtain the solid health-care beverage.
Comparative example 1
The comparative example provides a health drink for warming and recuperating kidney yang and improving cold constitution and a preparation method thereof.
The health drink for tonifying kidney yang and improving cold constitution at moderate temperature in the comparison example is prepared from the following raw materials in parts by weight:
0.8 part of polygonatum, 0.2 part of dried ginger, 1.2 parts of sealwort, 1.1 parts of mulberry, 1.2 parts of medlar, 1.8 parts of red date, 60 parts of honey and water to 1000 parts.
The preparation method comprises the following steps:
(1) respectively crushing the polygonatum and the dried ginger in parts by weight to obtain polygonatum coarse powder and dried ginger coarse powder; mixing rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, adding water, and wet pulverizing to obtain mixed crude powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae;
(2) mixing the coarse powder of rhizoma Polygonati Odorati and Zingiberis rhizoma with the mixed coarse powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, breaking cell wall, and extracting with water at normal temperature for 2 times; the method specifically comprises the following steps: under the condition that the temperature is less than or equal to 30 ℃, water extraction with the weight of 15-20 times of that of the medicinal powder is added for the first time, and water extraction with the weight of 10-15 times of that of the medicinal powder is added for the second time to obtain a water extraction solution. Then centrifugating (the rotating speed is 1500 r/min-15000 r/min), microfiltering (the aperture of a filter membrane is 500nm), carrying out reverse osmosis concentration treatment to obtain a concentrated solution with the solid content of 10-20%, and transferring the concentrated solution into a preparation tank.
(3) Weighing honey according to the preparation amount, adding a proper amount of drinking water, heating and stirring to dissolve, adding into a preparation tank, and stirring and mixing with the water extraction concentrated solution in the step (2) to obtain a preparation solution;
adding water into the prepared liquid to adjust the total amount to 1000 parts, filtering, sterilizing, filling and packaging to obtain the liquid health-care drink for warming and recuperating kidney yang and improving cold constitution.
Comparative example 2
The comparative example provides a health drink for warming and recuperating kidney yang and improving cold constitution and a preparation method thereof.
The health drink for tonifying kidney yang and improving cold constitution at moderate temperature in the comparison example is prepared from the following raw materials in parts by weight:
1.0 part of ginseng, 0.4 part of lily, 1.4 parts of rhizoma polygonati, 1.4 parts of mulberry, 1.4 parts of medlar, 2.0 parts of red date and maltodextrin with the net content of 50 percent.
The preparation method comprises the following steps:
(1) respectively pulverizing the ginseng and the lily to obtain ginseng coarse powder and lily coarse powder; mixing rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, adding water, and wet pulverizing to obtain mixed coarse powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae;
(2) respectively soaking or percolating the ginseng coarse powder and the lily coarse powder with 70% ethanol (at a temperature of less than 30 ℃), and recovering ethanol to obtain ginseng and lily ethanol extract;
(3) mixing the residue powder after alcohol extraction of Ginseng radix and Bulbus Lilii with mixed crude powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, performing wall breaking and water extraction at room temperature for 2 times, specifically: under the condition that the temperature is less than or equal to 30 ℃, water extraction with the weight of 15-20 times of that of the medicinal powder is added for the first time, and water extraction with the weight of 10-15 times of that of the medicinal powder is added for the second time to obtain a water extraction solution. Centrifuging (the rotating speed is 1500 r/min-15000 r/min), micro-filtering (the aperture of a filter membrane is 500nm), and performing reverse osmosis concentration treatment to obtain a concentrated solution;
(4) and placing the concentrated solution obtained by the reverse osmosis concentration treatment, the ginseng alcohol extract and the lily alcohol extract in a vacuum concentrator, setting the vacuum degree to be 0.08 MPa-0.1 MPa and the temperature to be 60-70 ℃ to obtain the concentrated solution with the solid content of 10-20%.
(5) And adding maltodextrin with the net content of 50% into the concentrated solution, uniformly mixing, performing spray drying, performing spray granulation, subpackaging and packaging to obtain the solid health-care beverage.
The formulas of the Chinese medicinal compositions in examples 1 to 6 and comparative examples 1 to 2 are shown in Table 1:
TABLE 1
Figure BDA0002393746930000191
Experimental example 1
The content of ginsenoside in the health drink of examples 1 to 6 and comparative examples 1 to 2 was measured, and the evaluation method was as follows:
chromatographic conditions and system applicability test: octadecylsilane chemically bonded silica is used as a filling agent; acetonitrile was used as mobile phase a, and 0.1% phosphoric acid solution was used as mobile phase B, and elution was performed with the gradient specified in table 2; the detection wavelength was 203 nm. The number of theoretical plates is determined by ginsenoside Rg1The peak calculation should not be below 2000.
TABLE 2
Time (minutes) Mobile phase A (%) Mobile phase B (%)
0 19 81
20 21 79
30 24 76
38 27 73
63 35 65
65 95 5
70 95 5
71 19 81
(1) Preparation of control solutions:
collecting ginsenoside Rg1Reference substance, ginsenoside RE reference substance, and ginsenoside Rb1Adding appropriate amount of reference substance, precisely weighing, and adding methanol to obtain Rg solutions each containing 30 μ g of the reference substance per 1ml1、30μg RE、30μg Rb1And (4) mixing the solution to obtain the finished product.
(2) Preparation of a test solution:
① liquid beverage is prepared by weighing 25 g of the liquid health beverage of examples 1-4 and comparative example 1, precisely weighing, placing in a separating funnel, shaking and extracting with water saturated n-butanol for 4 times (30ml, 30ml, 20ml, 20ml), mixing n-butanol solutions, washing with 1% sodium hydroxide solution for 2 times (25 ml each time), washing with n-butanol saturated water for 2 times (25 ml each time), taking n-butanol solution, evaporating to dryness, dissolving the residue with methanol, transferring to 25ml measuring flask, adding methanol to dilute to scale, shaking, filtering, and taking the filtrate.
② solid beverage is prepared by weighing 3g of the solid health beverage of examples 5-6 and comparative example 2, precisely weighing, dissolving in 25ml of hot water, placing in a separating funnel, shaking and extracting with water saturated n-butanol for 4 times (30ml, 30ml, 20ml, 20ml), mixing n-butanol solutions, washing with 1% sodium hydroxide solution for 2 times, 25ml each time, washing with n-butanol saturated water for 2 times, 25ml each time, taking n-butanol solution, evaporating to dryness, dissolving the residue with methanol, transferring to a 25ml measuring flask, adding methanol to dilute to scale, shaking, filtering, and collecting the filtrate.
The determination method comprises the following steps: respectively and precisely sucking 10-20 mul of reference solution and sample solution, injecting into a liquid chromatograph, and measuring.
Liquid beverage: containing ginsenoside Rg1(C42H72O14) Ginsenoside Re (C)48H82O18) Ginsenoside Rb1(C54H92O23) The total amount should not be less than 30. mu.g/g.
Solid beverage: containing ginsenoside Rg1(C42H72O14) Ginsenoside Re (C)48H82O18) Ginsenoside Rb1(C54H92O23) The total amount should not be less than 300. mu.g/g.
The test results are shown in table 3:
TABLE 3
Figure BDA0002393746930000211
Ginsenosides Rg of examples 4, 5, 6 and comparative example 21、Re、Rb1The total amount of the ginseng is higher, and the ginseng can better play the balance function of improving the brain oxygen uptake capacity, regulating the excitation process and the inhibition process of the central nervous system, the anti-fatigue function of the ginseng and the like, namely, the effects of nourishing yin, tonifying, strengthening the body resistance and consolidating the constitution of the ginseng are ensured, thereby ensuring the efficacy of the composition.
Experimental example 2
The effect experiment comparison is carried out on the health-care beverage for warming and recuperating kidney yang and improving cold constitution prepared in the examples 1-6 and the comparative examples 1-2.
The main symptoms of kidney deficiency: asthenia, deficiency of genuine qi, frequent micturition, excessive urine volume, especially at night, aversion to cold and cold limbs, and can be accompanied by soreness and pain of waist and knees, hyposexuality, lassitude, edema of lower limbs, short breath, asthma, loose stool, etc. A swollen and large tongue with white coating and a deep pulse. The female has chloasma on the face due to deficiency of qi and blood, and is often accompanied with irregular menstruation; insomnia, heavy dark circles, no precise collection, difficulty in concentration; aversion to cold, cold limbs, especially in autumn and winter; soreness and weakness of waist and knees, osteoporosis.
By consulting the literature and the discussion of the subject group members and clinicians, and trying by a small sample, the subjects with the following main symptoms are finally selected as the experimental subjects: frequent micturition, excessive urine volume, severe nocturnal emission, aversion to cold, irregular menstruation, dysmenorrhea, sallow complexion, azoospermia, lassitude, cold hands and feet, short breath, asthma, dizziness, night sweat, soreness of the waist, back pain or amnesia, insomnia, and various acute and chronic infectious diseases and infectious diseases have been excluded by basic examination. Total 80 persons, randomly divided into 8 groups of 10 persons each.
The experimental method comprises the following steps: 1 to 6 groups of the health-care beverage for warming and invigorating kidney yang and improving cold constitution prepared in the embodiment 1 to 6, 7 to 8 groups of the health-care beverage for warming and invigorating kidney yang and improving cold constitution prepared in the comparative example 1 and the comparative example 2 are respectively drunk, the drinking amount of the beverage for each group is the same every day, the beverage is continuously drunk for 30 days, and the symptom improvement condition is observed.
The Chinese medicine symptom scoring criteria are shown in Table 4:
TABLE 4
Symptoms and signs Slight (2 points) Moderate (4 points) Severe (6 points)
Night urination 2-3 times per night 4-5 times per night More than 5 times per night
Aversion to cold and cold limbs Cold limbs Cold limbs The whole body is cold and warm
Soreness of waist and knees Occasional attacks Recurrent attacks Sustained attack and difficult relief
Sexual disorder Decreased libido Occasional need for sex Impotence
Lassitude Lassitude Mental retardation of the stomach A dull and sluggish sensation in the mind
Shortness of breath and dyspnea Short breath after work Short breath when actuated Breathlessness in quiet
Treatment efficacy judgment criteria:
1. and (3) healing: the number of urination at night is 0-1, the limbs are warm, the soreness and pain of the waist and knees is obviously relieved or disappeared, the libido is obviously enhanced, the female menstruation is normal and the dysmenorrhea is not caused, the woman can feel glowing, the user can feel convenient and mentally shake, and the breathing is stable.
2. The effect is shown: night diuresis obviously improves or disappears, aversion to cold and cold limbs obviously reduce, hands and feet are warm, soreness and pain of waist and knees obviously reduces or disappears, libido is obviously enhanced, the people can feel glowing, and the people feel shiver and shortness of breath and asthma obviously improve or disappear.
3. The method has the following advantages: night diuresis, aversion to cold, cold limbs, soreness of waist and knees, short breath, asthma, etc., and can enhance sexual desire and facial skin.
4. And (4) invalidation: those who do not meet the above criteria and do not improve the above symptoms.
After taking the health drink for warming and recuperating kidney yang and improving cold physique, the symptom improvement of patients is shown in table 5:
TABLE 5
Figure BDA0002393746930000231
Figure BDA0002393746930000241
Figure BDA0002393746930000251
As can be seen from table 5, after patients take the health drink for warming and recuperating kidney yang and improving cold physique of embodiments 1 to 6 of the invention, the total effective rate is more than or equal to 90%, and the symptoms such as night diuresis, aversion to cold, cold limbs, soreness and pain of waist and knees, sexual dysfunction, lassitude, shortness of breath and asthma are all obviously improved; combining the comparative example 1 and the comparative example 2, it can be seen that if polygonatum is adopted as the monarch drug of the traditional Chinese medicine composition or lily is adopted as the ministerial drug of the traditional Chinese medicine composition, the prepared health-care beverage has slightly poor effect on treating cold symptoms such as night diuresis, intolerance of cold, cold limbs, soreness and pain of waist and knees, shortness of breath and asthma and the like.
The following are some specific cases:
case 1
Li in Li Dynasty, female, 38 years old, half-year irregular menstruation, scanty menstrual blood, even amenorrhea, sallow complexion, no essence, soreness and pain of waist and knees, cold limbs, listlessness, short breath in movement. After the liquid health-care beverage for warming and invigorating kidney yang and improving cold constitution provided by the invention is continuously drunk for half a month, hands and feet are warmed, and the symptoms of soreness and pain of waist and knees are relieved; after the liquid health-care drink for warming and invigorating kidney yang and improving cold physique provided by the invention is continuously drunk for one month, the menstruation is normal, the menstruation comes on time every month, the menstrual blood volume is increased more and more each time, the face is ruddy, the qi and blood are full, and the mental state is good. Evaluation of efficacy: has obvious effect.
Case 2
A woman in the age of 40 years old is cool in face and thin, is cold in hands and feet, is cold in uterus and is suffered from dysmenorrheal after autumn, is particularly cold-intolerant, is pale in complexion, is dizzy and dizzy, is short in breath and lazy to speak, is tired and weak, urinates at night (3-4 times per night), is listened, and is short in asthma. After the liquid health-care beverage for warming and invigorating kidney yang and improving cold constitution provided by the invention is continuously drunk for half a month, hands and feet are warmed, soreness and pain of waist and knees are relieved, and urination frequency at night is reduced to 1-2 times; after the liquid health-care beverage for warming and invigorating kidney yang and improving cold constitution provided by the invention is continuously drunk for one month, the menstruation is normal, the symptoms of dysmenorrhea are relieved, the number of urination at night is reduced to 0-1, the face is ruddy, the lower limbs cannot be cooled after sleeping at night, the complexion is good, the sleep is good, the spirit is good, and the whole person is bright and glowing. Evaluation of efficacy: has obvious effect.
Case 3
Zhao, a woman in age 35, aversion to cold, pale complexion, dizziness, lassitude. Due to work reasons, eyes stare at a display screen for a long time every day, particularly blood is injured, and the long time is long, so that qi and blood disharmony and visual deterioration are caused; insomnia for a long time leads to the appearance of bags and dark circles around the eyes. After the liquid health-care beverage for warming and invigorating kidney yang and improving cold constitution provided by the invention is continuously drunk for half a month, hands and feet are warmed, the symptom of intolerance of cold is relieved, and the number of insomnia is reduced; after the liquid health-care beverage for warming and invigorating kidney yang and improving cold constitution provided by the invention is continuously drunk for one month, the liquid health-care beverage can sleep and feel intact, black eyes and eye bags are reduced, the face color is ruddy, the complexion is good, the spirit is sufficient, and the whole person is bright and glowing. Evaluation of efficacy: has obvious effect.
Case 4
Shen somewhere, women, 49 years old will be diagnosed with nocturia and soreness and weakness of the loins and knees for 2 years. The frequency of urination at night is increased 2 years ago, 3-4 times per night, the urine volume is more than 100mL each time, the pain of waist and knees is accompanied, the limbs are cold, the spirit is low, and the movement causes the breathlessness. After the liquid health-care beverage for warming and recuperating kidney yang and improving cold constitution provided by the invention is continuously drunk for half a month, the number of urination at night is reduced to 2-3 times per night, the cold of limbs is relieved, and the phenomenon of shortness of breath is relieved when people move. After one month of administration, the nocturia frequency phenomenon disappears, the sleep quality is improved at night, and the waist and knees are not limp. Evaluation of efficacy: has obvious effect.
Case 5
Wangzhi, female, age 35, yellow and waxy face, dull eyes, severe anemia, cold limbs, pale face, severe alopecia, facial macula, frequent thoracic obstruction, stuffy breath in heart, stagnation of qi in chest, fullness in chest, hypochondriac inversion and heart robbing. After the solid health-care beverage for warming and invigorating kidney yang and improving cold constitution provided by the invention is continuously drunk for half a month, hands and feet are warmed, and the sleep quality is improved; after the solid health-care beverage for warming and invigorating kidney yang and improving cold constitution provided by the invention is continuously drunk for one month, the spots on the face gradually become light, the hair loss is reduced, the eyes are vivid, the complexion is good, the face is ruddy and active, and the chest distress symptom is relieved. Evaluation of efficacy: has obvious effect.
Case 6
Shen somewhere, men are 49 years old and have a diagnosis for 2 years due to increased nocturia and soreness and weakness of the loins and knees. The frequency of urination at night is increased 2 years ago, 3-4 times per night, the urine volume is more than 100mL each time, the pain of waist and knees is accompanied, the limbs are cold, the spirit is low, and the movement causes the breathlessness. The sexual desire is reduced and the sexual requirement is occasionally met. After the liquid health-care beverage for warming and recuperating kidney yang and improving cold constitution provided by the invention is continuously drunk for 2 weeks, the number of urination at night is reduced to 2-3 times per night, the cold of limbs is relieved, and the phenomenon of shortness of breath is relieved when people move. After taking for 3 weeks, soreness and weakness of waist and knees are improved, and sexual desire is recovered. After taking for 4 weeks, the nocturia frequency phenomenon disappears, the sleep quality is improved at night, the waist and knees are not limp, and the sexual function is normal. Evaluation of efficacy: has obvious effect.
Case 7
Qian should be taken as a diagnosis for women in 48 years because of nocturia and fatigue for 2 years. The number of urination at night is increased from the beginning of complaint for 2 years, 4-5 times per night, and the urine volume is more than 100mL each time, accompanied by lassitude. In recent 2 years, the symptoms of repeated onset and gradual aggravation, listlessness, soreness and pain of waist and knees, cold limbs and shortness of breath when moving occur. Traditional Chinese medicine diagnosis: frequent urination (syndrome of kidney yang deficiency). After the liquid health-care beverage for warming and recuperating kidney yang and improving cold physique is continuously drunk for 2 weeks, the night urination frequency is improved, the urination frequency is reduced to 2-3 times per night, the cold limbs are relieved, and the phenomenon of shortness of breath is relieved when the liquid health-care beverage is moved. After taking for 3 weeks, soreness and weakness of waist and knees are relieved, and sexual desire is normal. After 4 weeks of administration, the nocturia frequency phenomenon disappeared, no soreness and weakness of waist and knees, and normal sexual function. Evaluation of efficacy: has obvious effect.
Case 8
Li Shi, male, 41 years old, will be diagnosed with frequent nocturia for 3 years and more than 2019 for 4 months and 26 days. Frequent nocturia occurs 3 years ago, 4-5 times per night, and more frequent urination is caused each time, accompanied by aversion to cold, cold limbs, soreness and pain of waist and knees, spermatorrhea, premature ejaculation, amnesia, dreaminess, listlessness and short breath. The work pressure is large, the life is irregular, and the past history is denied. Traditional Chinese medicine diagnosis: frequent urination (syndrome of kidney yang deficiency). And (3) Western diagnosis: neurasthenia. After the liquid health-care beverage for warming and invigorating kidney yang and improving cold physique is continuously drunk for 2 weeks, the frequent nocturia is reduced, the frequency of urination at night is reduced to 2-3 times per night, and the symptoms such as chilly limbs, soreness and pain of waist and knees and the like are reduced. After taking the medicine for 3 weeks, the patient feels good at night, and the sexual desire is recovered, without spermatorrhea and premature ejaculation. After taking the medicine for 4 weeks, the nocturia frequency phenomenon disappears, and the symptoms such as intolerance of cold, cold limbs, soreness and pain of waist and knees, short breath and the like are avoided, and the libido is normal. Evaluation of efficacy: has obvious effect.
Case 9
When men are 50 years old, the physician needs to see more than 1 year in 5 months and 10 days in 2019 because of frequent nocturia, insomnia and amnesia. Since 1 year, the work pressure is high, the life is irregular, the number of urination at night is increased, about 4-5 times per night, and the urine volume is large each time. Accompanied by insomnia, amnesia, aversion to cold, cold limbs, soreness of waist and knees, lassitude, short breath, asthma, and loose stool. Deny the past history of other special diseases. Traditional Chinese medicine diagnosis: frequent urination (syndrome of kidney yang deficiency). And (3) Western diagnosis: neurasthenia. After the liquid health-care beverage for warming and invigorating kidney yang and improving cold physique is continuously drunk for 2 weeks, the number of urination at night is reduced to 2-3 times per night, insomnia, amnesia, intolerance of cold, cold limbs, soreness and pain of waist and knees, shortness of breath, asthma and other symptoms are relieved, and loose stool is avoided. After taking the medicine for 4 weeks, the nocturia disappears or 1 time per night, and the symptoms of insomnia, amnesia, chilly limbs, soreness and pain of waist and knees, lassitude, short breath, asthma and the like are avoided, and the stool is normal. Evaluation of efficacy: has obvious effect.
Case 10
In a male, 56 years old, the physician needs to visit the patient at 2019, 4 and 25 days since the patient frequently urinates at night for 3 months. The urine frequency increases at night since the complaint of the urine is about 3 months, and the urine is clear and long, about more than 5 times per night. Accompanied by soreness of the waist and knees, aversion to cold, cold limbs, sexual disorder, lassitude, shortness of breath and asthma. Deny the past history of other special diseases. Traditional Chinese medicine diagnosis: frequent urination (syndrome of kidney yang deficiency). After the liquid health-care beverage for warming and invigorating kidney yang and improving cold physique is continuously drunk for 2 weeks, the number of urination at night is reduced to 2-3 times per night, and symptoms such as soreness and pain of waist and knees, cold intolerance and cold limbs, sexual hypofunction, lassitude, shortness of breath and asthma are relieved. After taking the medicine for 4 weeks, the nocturia disappears, the symptoms such as soreness and pain of waist and knees, aversion to cold, cold limbs, short breath and asthma and the like do not exist, the spirit is better, and the sexual desire is obviously enhanced. Evaluation of efficacy: has obvious effect.
Case 11
Shen somewhere, men are 49 years old and have a diagnosis for 2 years due to increased nocturia and soreness and weakness of the loins and knees. The frequency of urination at night is increased 2 years ago, 3-4 times per night, the urine volume is more than 100mL each time, the pain of waist and knees is accompanied, the limbs are cold, the spirit is low, and the movement causes the breathlessness. The sexual desire is reduced and the sexual requirement is occasionally met. Traditional Chinese medicine diagnosis: frequent urination (syndrome of kidney yang deficiency). After the liquid health-care beverage for warming and recuperating kidney yang and improving cold constitution provided by the invention is continuously drunk for 2 weeks, the number of urination at night is reduced to 2-3 times per night, the cold of limbs is relieved, and the phenomenon of shortness of breath is relieved when people move. After taking the medicine for 3 weeks, the soreness and weakness of the waist and the knees are improved, and the sexual desire is recovered. After taking the medicine for 4 weeks, the nocturia frequency phenomenon disappears, the sleep quality is improved at night, the waist and knees are not limp, and the sexual function is normal. Evaluation of efficacy: has obvious effect.
Case 12
Qian should be treated for male in 48 years because of nocturia and fatigue for 2 years. The number of urination at night is increased from the beginning of complaint for 2 years, 4-5 times per night, and the urine volume is more than 100mL each time, accompanied by lassitude. In recent 2 years, the symptoms of repeated onset and gradual aggravation, listlessness, soreness and pain of waist and knees, cold limbs and shortness of breath when moving occur. The sexual desire is low. And (4) checking: the vital signs are normal, and no abnormality is seen in the heart and lung. The abdomen is flat and soft, no pain is present, the pain is relieved, the liver and the spleen are not touched, and no abnormality is found in the examination of the nervous system. A swollen and large tongue with a pale-red tongue with a white coating and a deep and slow pulse. Traditional Chinese medicine diagnosis: frequent urination (syndrome of kidney yang deficiency). After the liquid health-care beverage for warming and recuperating kidney yang and improving cold physique is continuously drunk for 2 weeks, the night urination frequency is improved, the urination frequency is reduced to 2-3 times per night, the cold limbs are relieved, and the phenomenon of shortness of breath is relieved when the liquid health-care beverage is moved. After taking the medicine for 3 weeks, the soreness and weakness of the waist and the knees are relieved, and the sexual desire is normal. After taking the medicine for 4 weeks, the nocturia frequency phenomenon disappears, no soreness and weakness of waist and knees and normal sexual function. Evaluation of efficacy: has obvious effect.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (10)

1. The traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution is characterized in that active ingredients of the traditional Chinese medicine composition are prepared from the following raw materials in parts by weight:
0.5-1.5 parts of ginseng, 0.1-1 part of dried ginger, 0.9-2 parts of rhizoma polygonati, 0.9-2 parts of mulberry, 0.9-2 parts of medlar and 1-3 parts of red date.
2. The traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution according to claim 1, wherein the active ingredients are prepared from the following raw materials in parts by weight:
0.8-1.2 parts of ginseng, 0.2-0.6 part of dried ginger, 1.0-1.6 parts of sealwort, 1.0-1.6 parts of mulberry, 1.0-1.6 parts of medlar and 1.8-2.5 parts of red date.
3. The traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution as claimed in claim 2, wherein the active ingredients are prepared from the following raw materials in parts by weight:
0.9 to 1.1 parts of ginseng, 0.3 to 0.5 parts of dried ginger, 1.2 to 1.5 parts of sealwort, 1.2 to 1.5 parts of mulberry, 1.2 to 1.5 parts of medlar and 1.9 to 2.2 parts of red date.
4. The method for preparing a traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution according to any one of claims 1 to 3, comprising the following steps:
respectively pulverizing the ginseng and the dried ginger to obtain ginseng coarse powder and dried ginger coarse powder; mixing rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, adding water, and wet pulverizing to obtain mixed coarse powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae;
mixing Ginseng radix coarse powder, Zingiberis rhizoma coarse powder and mixed coarse powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, adding water to break cell wall, extracting at room temperature for 2 times, centrifuging, microfiltering, and concentrating by reverse osmosis to obtain water extractive solution.
5. The preparation method of the traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution as claimed in claim 4, wherein the step of adding water to break the wall and extracting for 2 times at normal temperature comprises:
under the condition that the temperature is less than or equal to 30 ℃, water with the weight of 15-20 times of that of the medicinal powder is added for the first time, and water with the weight of 10-15 times of that of the medicinal powder is added for the second time.
6. The method for preparing a traditional Chinese medicine composition for warming and recuperating kidney yang and improving cold constitution according to any one of claims 1 to 3, comprising the following steps:
respectively pulverizing the ginseng and the dried ginger to obtain ginseng coarse powder and dried ginger coarse powder; mixing rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, adding water, and wet pulverizing to obtain mixed coarse powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae;
soaking or percolating the ginseng coarse powder and the dried ginger coarse powder with 70% ethanol, and recovering ethanol to obtain ginseng and dried ginger ethanol extract; mixing the residue powder of Ginseng radix and Zingiberis rhizoma with mixed crude powder slurry of rhizoma Polygonati, Mori fructus, fructus Lycii and fructus Jujubae, adding water to break cell wall, extracting at room temperature for 2 times, centrifuging, microfiltering, and concentrating by reverse osmosis to obtain water extractive solution, and mixing with the above alcoholic extractive solution of Ginseng radix and Zingiberis rhizoma.
7. The use of the Chinese medicinal composition according to any one of claims 1 to 3 in the preparation of a health drink for warming and recuperating kidney yang and improving cold constitution, wherein the dosage forms of the health drink comprise a liquid dosage form and a solid dosage form.
8. A health beverage for warming and recuperating kidney yang and improving cold constitution is characterized in that raw materials for preparing the health beverage comprise the traditional Chinese medicine composition of any one of claims 1 to 3 and auxiliary materials acceptable in the health beverage; the acceptable auxiliary materials in the health-care beverage are selected from one or a combination of more of water, honey, maltodextrin and Arabic gum.
9. The health drink for warming and recuperating kidney yang and improving cold constitution according to claim 8, wherein the extract of the Chinese medicinal composition accounts for 10-60% by mass of the raw materials for preparing the health drink.
10. According to claimThe health drink for warming and recuperating kidney yang and improving cold constitution according to claim 8 or 9, wherein the liquid formulation comprises: containing ginsenoside Rg1Ginsenoside Re and ginsenoside Rb1The total amount of the active ingredients is not less than 30 mu g/g;
solid dosage form: containing ginsenoside Rg1Ginsenoside Re and ginsenoside Rb1The total amount should not be less than 300. mu.g/g.
CN202010123604.0A 2020-02-27 2020-02-27 Traditional Chinese medicine composition for warming and invigorating kidney yang and improving cold constitution and preparation method and application thereof Pending CN111358922A (en)

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CN114223761A (en) * 2020-09-09 2022-03-25 抚松县广茂参业特产有限公司 Ginseng decoction ginseng health-care tea
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Application publication date: 20200703